TOPAZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.49453314
2regulation of meiosis I (GO:0060631)8.19321952
3meiotic nuclear division (GO:0007126)8.08802651
4male meiosis I (GO:0007141)7.97514851
5chromosome organization involved in meiosis (GO:0070192)7.90545642
6axonemal dynein complex assembly (GO:0070286)7.31658307
7multicellular organism reproduction (GO:0032504)7.22326442
8plasma membrane fusion (GO:0045026)7.17920918
9cell wall macromolecule metabolic process (GO:0044036)7.11531984
10cell wall macromolecule catabolic process (GO:0016998)7.11531984
11sperm-egg recognition (GO:0035036)7.00428131
12acrosome assembly (GO:0001675)6.73324822
13gene silencing by RNA (GO:0031047)6.63878983
14motile cilium assembly (GO:0044458)6.62330900
15meiosis I (GO:0007127)6.57027735
16sperm motility (GO:0030317)6.54395699
17histone H3-K9 demethylation (GO:0033169)6.36004989
18binding of sperm to zona pellucida (GO:0007339)6.34692929
19cell-cell recognition (GO:0009988)6.23259750
20spermatid development (GO:0007286)6.19972454
21epithelial cilium movement (GO:0003351)5.95773523
22reproduction (GO:0000003)5.66251460
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.66023900
24DNA alkylation (GO:0006305)5.63686208
25DNA methylation (GO:0006306)5.63686208
26meiotic cell cycle (GO:0051321)5.61712419
27meiotic cell cycle process (GO:1903046)5.31649973
28cilium movement (GO:0003341)5.30480168
29acrosome reaction (GO:0007340)5.26917187
30regulation of meiotic cell cycle (GO:0051445)4.82050827
31fertilization (GO:0009566)4.79505719
32nuclear pore complex assembly (GO:0051292)4.73189987
33germ cell development (GO:0007281)4.72691187
34spermatogenesis (GO:0007283)4.70657120
35regulation of female gonad development (GO:2000194)4.70543917
36male gamete generation (GO:0048232)4.69686273
37single fertilization (GO:0007338)4.61592067
38negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)4.56542708
39regulation of acrosome reaction (GO:0060046)4.55877168
40microtubule depolymerization (GO:0007019)4.55626167
41synapsis (GO:0007129)4.55167548
42gene silencing (GO:0016458)4.44139564
43nuclear pore organization (GO:0006999)4.40238964
44gamete generation (GO:0007276)4.38043915
45DNA methylation or demethylation (GO:0044728)4.33379198
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.30415059
47regulation of DNA methylation (GO:0044030)4.26794382
48oogenesis (GO:0048477)4.22083894
49sister chromatid cohesion (GO:0007062)4.18115239
50protein localization to chromosome (GO:0034502)4.12818766
51reciprocal DNA recombination (GO:0035825)4.05250904
52reciprocal meiotic recombination (GO:0007131)4.05250904
53positive regulation of meiosis (GO:0045836)4.03636018
54meiotic chromosome segregation (GO:0045132)4.00703830
55positive regulation of meiotic cell cycle (GO:0051446)3.94812066
56negative regulation of meiosis (GO:0045835)3.94495838
57regulation of cilium movement (GO:0003352)3.92367332
58retinal cone cell development (GO:0046549)3.70699260
59DNA biosynthetic process (GO:0071897)3.66874923
60monoubiquitinated protein deubiquitination (GO:0035520)3.66465368
61DNA modification (GO:0006304)3.59949702
62pore complex assembly (GO:0046931)3.59777884
63regulation of centriole replication (GO:0046599)3.55577158
64ventricular system development (GO:0021591)3.54289401
65regulation of histone H3-K9 methylation (GO:0051570)3.51774487
66DNA synthesis involved in DNA repair (GO:0000731)3.48434086
67attachment of spindle microtubules to kinetochore (GO:0008608)3.48269735
68interkinetic nuclear migration (GO:0022027)3.48149175
69heterochromatin organization (GO:0070828)3.44075893
70regulation of DNA endoreduplication (GO:0032875)3.41643920
71multicellular organismal reproductive process (GO:0048609)3.40113600
72histone H3-K36 demethylation (GO:0070544)3.39816131
73centriole assembly (GO:0098534)3.39562409
74centriole replication (GO:0007099)3.39549419
75reproductive system development (GO:0061458)3.39259783
76positive regulation of histone H3-K4 methylation (GO:0051571)3.37584739
77negative regulation of inclusion body assembly (GO:0090084)3.37546648
78histone exchange (GO:0043486)3.32470530
79CENP-A containing nucleosome assembly (GO:0034080)3.28870497
80female gamete generation (GO:0007292)3.26377250
81sex differentiation (GO:0007548)3.17183514
82protein K6-linked ubiquitination (GO:0085020)3.16651956
83proteasome assembly (GO:0043248)3.16392866
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15918127
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15918127
86positive regulation of mitotic sister chromatid separation (GO:1901970)3.15918127
87DNA replication-dependent nucleosome assembly (GO:0006335)3.15314538
88DNA replication-dependent nucleosome organization (GO:0034723)3.15314538
89histone lysine demethylation (GO:0070076)3.14850859
90mitotic metaphase plate congression (GO:0007080)3.12154880
91positive regulation of translational initiation (GO:0045948)3.11617665
92regulation of protein polyubiquitination (GO:1902914)3.11400949
93regulation of meiosis (GO:0040020)3.10805057
94sperm capacitation (GO:0048240)3.09200059
95chromatin remodeling at centromere (GO:0031055)3.07897902
96negative regulation of reproductive process (GO:2000242)3.07354517
97regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)3.07271823
98seminiferous tubule development (GO:0072520)3.07008203
99genitalia morphogenesis (GO:0035112)3.05559594
100protein localization to cilium (GO:0061512)3.02167139
101histone demethylation (GO:0016577)3.01673117
102negative regulation of organelle assembly (GO:1902116)2.92852809
103protein localization to kinetochore (GO:0034501)2.90193168
104nuclear division (GO:0000280)2.87143452
105resolution of meiotic recombination intermediates (GO:0000712)2.86614321
106oocyte development (GO:0048599)2.86345517
107positive regulation of histone methylation (GO:0031062)2.85877738
108oocyte maturation (GO:0001556)2.83008305
109chromosome organization (GO:0051276)2.82620803
110cell recognition (GO:0008037)2.79329660
111mitotic sister chromatid cohesion (GO:0007064)2.79006701
112chaperone-mediated protein complex assembly (GO:0051131)2.78971927
113mitotic chromosome condensation (GO:0007076)2.78766178
114protein demethylation (GO:0006482)2.75385364
115protein dealkylation (GO:0008214)2.75385364
116organelle fission (GO:0048285)2.73735424
117blastocyst development (GO:0001824)2.73527952
118nucleus organization (GO:0006997)2.73354367
119DNA packaging (GO:0006323)2.73203017
120regulation of spindle checkpoint (GO:0090231)2.72836377
121negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.71606174
122regulation of double-strand break repair (GO:2000779)2.71013747
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.70493750
124negative regulation of DNA repair (GO:0045738)2.69516622
125regulation of chromatin binding (GO:0035561)2.69204526
126regulation of transcription from RNA polymerase I promoter (GO:0006356)2.67103671
127DNA replication-independent nucleosome assembly (GO:0006336)2.66742358
128DNA replication-independent nucleosome organization (GO:0034724)2.66742358
129histone H2A acetylation (GO:0043968)2.64243146
130negative regulation of gene silencing (GO:0060969)2.64047119
131regulation of steroid hormone secretion (GO:2000831)2.63339652
132regulation of chromatin silencing (GO:0031935)2.62481879
133establishment of chromosome localization (GO:0051303)2.59075550
134metaphase plate congression (GO:0051310)2.57919821
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56716264
136protein localization to chromosome, centromeric region (GO:0071459)2.55420845
137piRNA metabolic process (GO:0034587)16.6845907
138DNA methylation involved in gamete generation (GO:0043046)12.5328040
139male meiosis (GO:0007140)11.5497172
140cilium or flagellum-dependent cell motility (GO:0001539)11.0335135
141synaptonemal complex assembly (GO:0007130)10.8999138
142synaptonemal complex organization (GO:0070193)10.6701034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26841342
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.65661025
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92502748
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79647749
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70893524
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60402228
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51926756
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.50387386
9EZH2_22144423_ChIP-Seq_EOC_Human2.46304300
10VDR_22108803_ChIP-Seq_LS180_Human2.44195812
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.39761170
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24558758
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18978048
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.15151963
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.14999915
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10383399
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03921076
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.03358262
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.4482544
20GBX2_23144817_ChIP-Seq_PC3_Human1.99642856
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96568063
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90910775
23TAF15_26573619_Chip-Seq_HEK293_Human1.90169064
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84618358
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81967605
26IGF1R_20145208_ChIP-Seq_DFB_Human1.81810605
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80990461
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.80577439
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80171612
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77335822
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75504070
32ER_23166858_ChIP-Seq_MCF-7_Human1.73482695
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68229590
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66162400
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.64447259
36AR_21909140_ChIP-Seq_LNCAP_Human1.61902902
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60508885
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.59128869
39STAT3_23295773_ChIP-Seq_U87_Human1.58527447
40RUNX1_26923725_Chip-Seq_HPCs_Mouse1.57743464
41EWS_26573619_Chip-Seq_HEK293_Human1.56651700
42RNF2_27304074_Chip-Seq_NSC_Mouse1.54542942
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53068375
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49437586
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.46718530
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46510457
47P300_19829295_ChIP-Seq_ESCs_Human1.45884850
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44748028
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43196404
50CBP_20019798_ChIP-Seq_JUKART_Human1.43196404
51STAT1_17558387_ChIP-Seq_HELA_Human1.43084172
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.41493641
53AR_25329375_ChIP-Seq_VCAP_Human1.41140282
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38799411
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.37317600
56RUNX2_22187159_ChIP-Seq_PCA_Human1.37073247
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35598539
58SMAD4_21799915_ChIP-Seq_A2780_Human1.32606363
59HTT_18923047_ChIP-ChIP_STHdh_Human1.32600173
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.31272265
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30331054
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30264010
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28223514
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27836838
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27331471
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25935561
67TP53_22573176_ChIP-Seq_HFKS_Human1.24674427
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.22690076
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21355379
70SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19489222
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.18386802
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18156372
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17412192
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16761508
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16390529
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.15102692
77IRF1_19129219_ChIP-ChIP_H3396_Human1.14693759
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.14541055
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.13085832
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12670838
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11197316
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10739405
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10570742
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10500978
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10500978
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10500978
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.10321322
88NANOG_19829295_ChIP-Seq_ESCs_Human1.10118879
89SOX2_19829295_ChIP-Seq_ESCs_Human1.10118879
90GATA3_26560356_Chip-Seq_TH1_Human1.10010344
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.09318348
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08705313
93FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08164324
94GATA3_21867929_ChIP-Seq_CD8_Mouse1.08104515
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07979777
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.07445512
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07164529
98TCF4_22108803_ChIP-Seq_LS180_Human1.06512473
99MYC_18940864_ChIP-ChIP_HL60_Human1.06299605
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05928615
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04730390
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03156594
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.03156594
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03039158
105GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.02959246
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02286240
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01957694
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.01389832
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01106452
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00755515
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00561733
112FOXH1_21741376_ChIP-Seq_EPCs_Human1.00362881
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99048681
114OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97296583
115CBP_21632823_ChIP-Seq_H3396_Human0.97225150
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96708612
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96684781
118CDX2_22108803_ChIP-Seq_LS180_Human0.96350050
119NFYB_21822215_ChIP-Seq_K562_Human0.96261981
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95776829
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.95599905
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.95372945
123TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.95051585
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94689862
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93961737
126P300_18555785_Chip-Seq_ESCs_Mouse0.93007729
127NCOR_22424771_ChIP-Seq_293T_Human0.92210690
128TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91565891
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91305185
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91257688
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90832794
132GF1_26923725_Chip-Seq_HPCs_Mouse0.90656859
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90620181
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89337075
135BCAT_22108803_ChIP-Seq_LS180_Human0.88429081
136ZFX_18555785_Chip-Seq_ESCs_Mouse0.88356337
137TCF4_23295773_ChIP-Seq_U87_Human0.88219965
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87894096
139P53_22387025_ChIP-Seq_ESCs_Mouse0.87538721
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.86215196
141CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85758112
142HOXB7_26014856_ChIP-Seq_BT474_Human0.85335681
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85083004
144FUS_26573619_Chip-Seq_HEK293_Human0.84556386
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84390347
146ETV1_20927104_ChIP-Seq_GIST48_Human0.83911034
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83843418
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83843418
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.83495837
150CTCF_18555785_Chip-Seq_ESCs_Mouse0.83420756
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.83295105
152AR_20517297_ChIP-Seq_VCAP_Human0.82875821
153SOX2_18555785_Chip-Seq_ESCs_Mouse0.82826932
154ZNF274_21170338_ChIP-Seq_K562_Hela0.81927566
155SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81685379
156PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81666946
157STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81565222
158SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81424533
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.80891769
160PHF8_20622853_ChIP-Seq_HELA_Human0.80429249
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80323219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.63180059
2MP0001929_abnormal_gametogenesis5.02586017
3MP0002210_abnormal_sex_determination4.76990151
4MP0003698_abnormal_male_reproductive4.63823878
5MP0008995_early_reproductive_senescence4.02265926
6MP0001145_abnormal_male_reproductive3.82981372
7MP0000653_abnormal_sex_gland3.49549850
8MP0010094_abnormal_chromosome_stability3.40530685
9MP0008058_abnormal_DNA_repair3.30864449
10MP0008057_abnormal_DNA_replication3.22080295
11MP0003786_premature_aging2.98144037
12MP0008789_abnormal_olfactory_epithelium2.93505491
13MP0002653_abnormal_ependyma_morphology2.68043581
14MP0002161_abnormal_fertility/fecundity2.66245230
15MP0005499_abnormal_olfactory_system2.30813851
16MP0005394_taste/olfaction_phenotype2.30813851
17MP0003183_abnormal_peptide_metabolism2.27380187
18MP0003111_abnormal_nucleus_morphology2.17953356
19MP0001986_abnormal_taste_sensitivity2.10692920
20MP0008877_abnormal_DNA_methylation10.4496716
21MP0000678_abnormal_parathyroid_gland1.94361842
22MP0005623_abnormal_meninges_morphology1.82635452
23MP0002160_abnormal_reproductive_system1.79776682
24MP0003077_abnormal_cell_cycle1.78366526
25MP0008004_abnormal_stomach_pH1.76924624
26MP0003693_abnormal_embryo_hatching1.64912059
27MP0003950_abnormal_plasma_membrane1.62410691
28MP0003718_maternal_effect1.62134872
29MP0004957_abnormal_blastocyst_morpholog1.61605503
30MP0008007_abnormal_cellular_replicative1.57223939
31MP0003879_abnormal_hair_cell1.56727711
32MP0002138_abnormal_hepatobiliary_system1.47217729
33MP0003890_abnormal_embryonic-extraembry1.46508268
34MP0003123_paternal_imprinting1.42725094
35MP0002139_abnormal_hepatobiliary_system1.41749348
36MP0001119_abnormal_female_reproductive1.38468668
37MP0005423_abnormal_somatic_nervous1.29250593
38MP0005647_abnormal_sex_gland1.25525045
39MP0005360_urolithiasis1.23952405
40MP0004233_abnormal_muscle_weight1.23820464
41MP0001730_embryonic_growth_arrest1.22244478
42MP0004808_abnormal_hematopoietic_stem1.21003488
43MP0010307_abnormal_tumor_latency1.17279605
44MP0003136_yellow_coat_color1.16916915
45MP0002102_abnormal_ear_morphology1.13024910
46MP0010030_abnormal_orbit_morphology1.12314323
47MP0008932_abnormal_embryonic_tissue1.11889545
48MP0003699_abnormal_female_reproductive1.09375808
49MP0001984_abnormal_olfaction1.07339657
50MP0005389_reproductive_system_phenotype1.05071247
51MP0003787_abnormal_imprinting1.02621788
52MP0005646_abnormal_pituitary_gland1.01894548
53MP0003646_muscle_fatigue0.98272720
54MP0000631_abnormal_neuroendocrine_gland0.97389114
55MP0001664_abnormal_digestion0.96769462
56MP0005551_abnormal_eye_electrophysiolog0.88543225
57MP0006276_abnormal_autonomic_nervous0.85851407
58MP0005377_hearing/vestibular/ear_phenot0.84263266
59MP0003878_abnormal_ear_physiology0.84263266
60MP0000350_abnormal_cell_proliferation0.83982122
61MP0009379_abnormal_foot_pigmentation0.82801724
62MP0005380_embryogenesis_phenotype0.82278439
63MP0001672_abnormal_embryogenesis/_devel0.82278439
64MP0005670_abnormal_white_adipose0.82163690
65MP0002084_abnormal_developmental_patter0.80738169
66MP0004197_abnormal_fetal_growth/weight/0.78947421
67MP0001697_abnormal_embryo_size0.77174113
68MP0002085_abnormal_embryonic_tissue0.74901114
69MP0003121_genomic_imprinting0.73250309
70MP0000313_abnormal_cell_death0.72320415
71MP0010352_gastrointestinal_tract_polyps0.68757087
72MP0003984_embryonic_growth_retardation0.68634732
73MP0002009_preneoplasia0.67733903
74MP0001502_abnormal_circadian_rhythm0.67444822
75MP0010368_abnormal_lymphatic_system0.67351110
76MP0002272_abnormal_nervous_system0.66633434
77MP0001485_abnormal_pinna_reflex0.66063304
78MP0005395_other_phenotype0.64190246
79MP0001661_extended_life_span0.63963921
80MP0001727_abnormal_embryo_implantation0.62723127
81MP0002088_abnormal_embryonic_growth/wei0.62426847
82MP0000049_abnormal_middle_ear0.61425023
83MP0000569_abnormal_digit_pigmentation0.60310407
84MP0000372_irregular_coat_pigmentation0.59150196
85MP0000427_abnormal_hair_cycle0.57721295
86MP0003936_abnormal_reproductive_system0.57507012
87MP0003941_abnormal_skin_development0.55075509
88MP0002095_abnormal_skin_pigmentation0.55014667
89MP0002019_abnormal_tumor_incidence0.54651120
90MP0001666_abnormal_nutrient_absorption0.54002897
91MP0002080_prenatal_lethality0.53986583
92MP0006138_congestive_heart_failure0.53723027
93MP0001963_abnormal_hearing_physiology0.53705558
94MP0001293_anophthalmia0.51908430
95MP0004043_abnormal_pH_regulation0.50744720
96MP0005666_abnormal_adipose_tissue0.50560436
97MP0002229_neurodegeneration0.50061993
98MP0002086_abnormal_extraembryonic_tissu0.48179703
99MP0002970_abnormal_white_adipose0.48017435
100MP0003315_abnormal_perineum_morphology0.47207400
101MP0002282_abnormal_trachea_morphology0.47084807
102MP0004142_abnormal_muscle_tone0.46417296
103MP0003195_calcinosis0.45673831
104MP0003861_abnormal_nervous_system0.44656727
105MP0005076_abnormal_cell_differentiation0.43242582
106MP0001501_abnormal_sleep_pattern0.43241192
107MP0004885_abnormal_endolymph0.43234361
108MP0002971_abnormal_brown_adipose0.42990422
109MP0003252_abnormal_bile_duct0.42918382
110MP0000432_abnormal_head_morphology0.42858271
111MP0005174_abnormal_tail_pigmentation0.41837546
112MP0000015_abnormal_ear_pigmentation0.41565879
113MP0010678_abnormal_skin_adnexa0.41103029
114MP0003115_abnormal_respiratory_system0.40895338
115MP0004215_abnormal_myocardial_fiber0.40561597
116MP0001915_intracranial_hemorrhage0.39672633
117MP0005085_abnormal_gallbladder_physiolo0.39480677
118MP0009697_abnormal_copulation0.39409048
119MP0009046_muscle_twitch0.39295806
120MP0001324_abnormal_eye_pigmentation0.39264100
121MP0000026_abnormal_inner_ear0.38518244
122MP0009672_abnormal_birth_weight0.38367781
123MP0006072_abnormal_retinal_apoptosis0.37934776
124MP0009703_decreased_birth_body0.37755956
125MP0006036_abnormal_mitochondrial_physio0.37483480
126MP0009745_abnormal_behavioral_response0.36549888
127MP0001188_hyperpigmentation0.36270040
128MP0003935_abnormal_craniofacial_develop0.36218356
129MP0003119_abnormal_digestive_system0.35720193
130MP0009278_abnormal_bone_marrow0.35048720
131MP0005397_hematopoietic_system_phenotyp0.34929420
132MP0001545_abnormal_hematopoietic_system0.34929420
133MP0000383_abnormal_hair_follicle0.34554530
134MP0002269_muscular_atrophy0.34134374
135MP0006292_abnormal_olfactory_placode0.32981390
136MP0002233_abnormal_nose_morphology0.32786417
137MP0000358_abnormal_cell_content/0.32501326
138MP0005391_vision/eye_phenotype0.32377280
139MP0005253_abnormal_eye_physiology0.31318542
140MP0005409_darkened_coat_color0.30525268
141MP0003937_abnormal_limbs/digits/tail_de0.30477134
142MP0000462_abnormal_digestive_system0.30423844
143MP0002234_abnormal_pharynx_morphology0.29138163
144MP0004019_abnormal_vitamin_homeostasis0.29132101
145MP0001919_abnormal_reproductive_system0.28701978
146MP0000647_abnormal_sebaceous_gland0.27977366
147MP0005451_abnormal_body_composition0.27546238
148MP0002092_abnormal_eye_morphology0.26812720
149MP0009115_abnormal_fat_cell0.26806630
150MP0003828_pulmonary_edema0.25683061

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.80560969
2Abnormal respiratory motile cilium morphology (HP:0005938)7.39786025
3Abnormal respiratory epithelium morphology (HP:0012253)7.39786025
4Rhinitis (HP:0012384)6.53105968
5Abnormal ciliary motility (HP:0012262)6.51585735
6Azoospermia (HP:0000027)5.78446579
7Chronic bronchitis (HP:0004469)5.62239382
8Abnormal spermatogenesis (HP:0008669)5.22013308
9Nasal polyposis (HP:0100582)4.83944213
10Infertility (HP:0000789)4.61300469
11Abnormality of the lower motor neuron (HP:0002366)4.47562015
12Nephronophthisis (HP:0000090)4.32666400
13Gonadotropin excess (HP:0000837)4.04960416
14Bronchiectasis (HP:0002110)3.88992825
15Abnormality of the nasal mucosa (HP:0000433)3.86508613
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.68884788
17Short tibia (HP:0005736)3.56967582
18Volvulus (HP:0002580)3.48233041
19Bronchitis (HP:0012387)3.31719023
20Abnormality of the renal medulla (HP:0100957)3.30187721
21Impulsivity (HP:0100710)3.26396515
22Osteomalacia (HP:0002749)3.25003541
23Abdominal situs inversus (HP:0003363)3.22047118
24Abnormality of abdominal situs (HP:0011620)3.22047118
25Lip pit (HP:0100267)3.20144866
26Abnormality of the labia minora (HP:0012880)3.17282754
27Premature ovarian failure (HP:0008209)3.15403165
28Loss of speech (HP:0002371)3.14691259
29Oligodactyly (HP:0012165)3.12254016
30Male infertility (HP:0003251)2.97760080
31Chromsome breakage (HP:0040012)2.92591875
32Amyotrophic lateral sclerosis (HP:0007354)2.89761928
33Recurrent sinusitis (HP:0011108)2.82216913
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81687225
35Fibular hypoplasia (HP:0003038)2.76720821
36Fair hair (HP:0002286)2.75273234
37Renovascular hypertension (HP:0100817)2.69888581
38Supernumerary spleens (HP:0009799)2.68347186
39Hypophosphatemic rickets (HP:0004912)2.65121221
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64813587
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.64813587
42Medial flaring of the eyebrow (HP:0010747)2.64519318
4311 pairs of ribs (HP:0000878)2.62196766
44Hypoplasia of the fovea (HP:0007750)2.62157585
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.62157585
46Recurrent otitis media (HP:0000403)2.59407551
47Anterior segment dysgenesis (HP:0007700)2.58692237
48Upper motor neuron abnormality (HP:0002127)2.58489978
49Congenital sensorineural hearing impairment (HP:0008527)2.57716858
50Wrist flexion contracture (HP:0001239)2.46100005
51Tubular atrophy (HP:0000092)2.45895077
52Abnormality of the fovea (HP:0000493)2.43753723
53Tubulointerstitial nephritis (HP:0001970)2.42741698
54Abnormality of chromosome segregation (HP:0002916)2.36947208
55Impaired vibration sensation in the lower limbs (HP:0002166)2.35029589
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33610722
57Gaze-evoked nystagmus (HP:0000640)2.32948235
58Stage 5 chronic kidney disease (HP:0003774)2.31503470
59Papillary thyroid carcinoma (HP:0002895)2.30767317
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.30720127
61Facial cleft (HP:0002006)2.30681350
62Abnormal lung lobation (HP:0002101)2.25140024
63Enlarged penis (HP:0000040)2.24336494
64Sensory axonal neuropathy (HP:0003390)2.21391785
65Abnormality of DNA repair (HP:0003254)2.20975059
66Clitoromegaly (HP:0000057)2.16493981
67Abnormality of chromosome stability (HP:0003220)2.14644261
68Ectopic kidney (HP:0000086)2.13890245
69Abnormality of the carotid arteries (HP:0005344)2.12686512
70Abnormality of the renal cortex (HP:0011035)2.11460486
71Poor coordination (HP:0002370)2.11386638
72Upper limb muscle weakness (HP:0003484)2.11314266
73Abnormality of the anterior horn cell (HP:0006802)2.09188587
74Degeneration of anterior horn cells (HP:0002398)2.09188587
75Non-midline cleft lip (HP:0100335)2.06990230
76Increased nuchal translucency (HP:0010880)2.06734593
77Abnormality of the corticospinal tract (HP:0002492)2.05879272
78Abnormality of lateral ventricle (HP:0030047)2.05134053
79Bony spicule pigmentary retinopathy (HP:0007737)2.04892403
80Hyperpituitarism (HP:0010514)2.04074998
81Abnormal gallbladder physiology (HP:0012438)2.02494996
82Cholecystitis (HP:0001082)2.02494996
83Urethral obstruction (HP:0000796)2.01221298
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6612386
85Dynein arm defect of respiratory motile cilia (HP:0012255)10.1988456
86Absent/shortened dynein arms (HP:0200106)10.1988456
87Central scotoma (HP:0000603)1.99974453
88Hyperacusis (HP:0010780)1.97694134
89Congenital primary aphakia (HP:0007707)1.97403227
90Hand muscle atrophy (HP:0009130)1.96012807
91Abnormality of alanine metabolism (HP:0010916)1.95993115
92Hyperalaninemia (HP:0003348)1.95993115
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95993115
94Gait imbalance (HP:0002141)1.95175361
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.95064943
96Impaired proprioception (HP:0010831)1.92907938
97Horizontal nystagmus (HP:0000666)1.92810283
98Proximal tubulopathy (HP:0000114)1.92092377
99Absent septum pellucidum (HP:0001331)1.92082363
100Overriding aorta (HP:0002623)1.92081977
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.91637995
102Microglossia (HP:0000171)1.90943996
103Generalized hypopigmentation of hair (HP:0011358)1.90132888
104Abnormality of the labia (HP:0000058)1.90035362
105Elfin facies (HP:0004428)1.89865689
106Postaxial foot polydactyly (HP:0001830)1.89563921
107Renal duplication (HP:0000075)1.89423960
108Preaxial hand polydactyly (HP:0001177)1.89354081
109Abnormality of the duodenum (HP:0002246)1.89084796
110Abnormality of cochlea (HP:0000375)1.88976751
111Short ribs (HP:0000773)1.88064701
112Stillbirth (HP:0003826)1.87991041
113Selective tooth agenesis (HP:0001592)1.87398221
114Meckel diverticulum (HP:0002245)1.87344196
115Absent thumb (HP:0009777)1.84791887
116Attenuation of retinal blood vessels (HP:0007843)1.82681533
117Bundle branch block (HP:0011710)1.82514228
118Abnormality of the preputium (HP:0100587)1.82100146
119Scotoma (HP:0000575)1.80867786
120Abnormality of the renal collecting system (HP:0004742)1.78988385
121Spontaneous abortion (HP:0005268)1.78859085
122Recurrent bronchitis (HP:0002837)1.78038784
123Toxemia of pregnancy (HP:0100603)1.77828230
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76006872
125Median cleft lip (HP:0000161)1.75514328
126Molar tooth sign on MRI (HP:0002419)1.74518110
127Abnormality of midbrain morphology (HP:0002418)1.74518110
128Poikiloderma (HP:0001029)1.74453600
129Tubulointerstitial abnormality (HP:0001969)1.74424741
130Abnormality of the ileum (HP:0001549)1.72560452
131Heterotopia (HP:0002282)1.71950777
132Chronic sinusitis (HP:0011109)1.71465933
133Nephroblastoma (Wilms tumor) (HP:0002667)1.69428602
134Facial hemangioma (HP:0000329)1.68812147
135Sloping forehead (HP:0000340)1.68803831
136Duplicated collecting system (HP:0000081)1.63776939
137Nephrogenic diabetes insipidus (HP:0009806)1.63334993
138Flat cornea (HP:0007720)1.62808267
139Breast carcinoma (HP:0003002)1.62696750
140Conjunctival telangiectasia (HP:0000524)1.55948948
141Renal dysplasia (HP:0000110)1.54877376
142Abnormality of ocular smooth pursuit (HP:0000617)1.53667993
143Embryonal renal neoplasm (HP:0011794)1.53095864
144Truncal obesity (HP:0001956)1.52706816
145Postaxial hand polydactyly (HP:0001162)1.50356380
146Oligodactyly (hands) (HP:0001180)1.50130812
147Capillary hemangiomas (HP:0005306)1.48897626
148Genital tract atresia (HP:0001827)1.48734582
149Congenital hepatic fibrosis (HP:0002612)1.48411482
150Tongue fasciculations (HP:0001308)1.47999671
151Insomnia (HP:0100785)1.47435866
152Hypoplasia of the radius (HP:0002984)1.46752601
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.45561572
154Missing ribs (HP:0000921)1.44696305
155Hyporeflexia of lower limbs (HP:0002600)1.44655978
156Small intestinal stenosis (HP:0012848)1.44624819
157Duodenal stenosis (HP:0100867)1.44624819
158Abnormality of the diencephalon (HP:0010662)1.44276063
159Short thumb (HP:0009778)1.43918511
160Muscle fibrillation (HP:0010546)1.42722087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.33721818
2PDK37.33721818
3PDK24.68103880
4CDK194.41222182
5CDK123.97442725
6CDC73.71931403
7ACVR1B3.24773787
8PRKD33.17745620
9MAP3K93.11039377
10FRK2.91062634
11MAP3K132.84661931
12NEK22.67047678
13MET2.60825903
14ARAF2.57526323
15NEK92.46656854
16ICK2.32891817
17TAOK32.28190342
18NEK62.26814315
19OXSR12.26193967
20TESK12.25939377
21PLK41.88360992
22CHEK21.82562771
23WEE11.80388578
24STK241.80262497
25TTK1.77922641
26PNCK1.71252300
27PRKCI1.69428008
28PLK21.66829441
29STK161.64949247
30STK391.61945553
31EIF2AK31.60656139
32BRD41.49405094
33PTK2B1.49236998
34STK38L1.49039408
35CHEK11.46701091
36WNK41.44936477
37PLK11.39817252
38MOS1.38250731
39ATR1.25127476
40STK31.23373010
41ZAK1.21703208
42TYRO31.12989309
43MAPK131.10783626
44ATM1.08318705
45RAF11.05183224
46IRAK11.03771658
47MAP3K40.99278905
48INSRR0.96633896
49TRIM280.90502736
50STK380.89545485
51NTRK30.89074087
52WNK10.87856082
53CDK70.79810030
54CDK90.78781132
55PASK0.78386264
56LMTK20.77359114
57ADRBK20.73820008
58NTRK20.73688283
59BRSK20.70740471
60KSR10.67718520
61AURKB0.66428808
62CCNB10.66340560
63MTOR0.65104414
64BMPR1B0.64449731
65CDK40.64355225
66MST40.62899146
67NLK0.61005917
68MELK0.60924235
69SCYL20.59019651
70DYRK30.58433567
71CAMK1G0.56299226
72CAMK1D0.55329180
73MAP3K50.54489286
74CDK20.54171384
75PRKG10.53808529
76BUB10.53714901
77TNK20.51698195
78CDK10.50132832
79DYRK1B0.48969796
80CSF1R0.48107920
81RIPK10.46643207
82PDPK10.44287773
83PDGFRB0.43774674
84WNK30.43672263
85TNIK0.42315140
86PRKCE0.40796366
87PBK0.40654039
88PRKDC0.38901512
89KSR20.38647024
90CDK30.37869842
91BCR0.37077940
92GRK10.35899075
93AKT20.35400213
94MAP3K60.34627175
95TGFBR10.34404263
96EPHA40.34051201
97BRSK10.33954405
98YES10.33921716
99CAMK2A0.33534897
100IRAK20.33008169
101MAPK150.32663317
102STK110.32136466
103PRKD20.31306039
104PRKCZ0.31294041
105CSNK1D0.30574237
106SGK10.30253168
107CSNK2A20.29107377
108PKN10.28831574
109STK40.28644551
110SRPK10.28382885
111CSNK1G10.27548954
112PDK10.27004888
113AURKA0.26906057
114PRKAA10.26721237
115PRKACA0.25763529
116GSK3B0.25712585
117AKT30.24346024
118MAPK100.23921619
119CSNK1E0.22423782
120CSNK2A10.22379281
121PLK30.22319138
122LATS10.22196974
123TEC0.21970500
124PINK10.21842485
125MKNK20.21769322
126TLK10.20910486
127PIM10.20469673
128MARK30.20390215
129MAPK80.15940370
130NUAK10.15537454
131RPS6KB10.15009333
132MAPK140.14443863
133MAP2K70.13398576
134VRK10.12858261
135CDC42BPA0.12556137
136LATS20.11836935
137AKT10.11028496
138BRAF0.10286697
139MAPK10.09659859
140EGFR0.09338084
141PRKACB0.09156412
142EIF2AK10.08381574
143RPS6KA10.08011040
144CDK60.07654276

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.25497460
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.30714020
3Fanconi anemia pathway_Homo sapiens_hsa034604.13886932
4Homologous recombination_Homo sapiens_hsa034403.78504822
5RNA transport_Homo sapiens_hsa030133.08123128
6Dorso-ventral axis formation_Homo sapiens_hsa043203.00534127
7Vitamin B6 metabolism_Homo sapiens_hsa007502.90148482
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.88531088
9Cell cycle_Homo sapiens_hsa041102.67705593
10Non-homologous end-joining_Homo sapiens_hsa034502.62785493
11Selenocompound metabolism_Homo sapiens_hsa004502.61877718
12mRNA surveillance pathway_Homo sapiens_hsa030152.55417544
13DNA replication_Homo sapiens_hsa030302.38948369
14Pentose phosphate pathway_Homo sapiens_hsa000302.33179500
15Mismatch repair_Homo sapiens_hsa034302.18732432
16Oocyte meiosis_Homo sapiens_hsa041142.14051931
17Pyruvate metabolism_Homo sapiens_hsa006202.04316298
18Olfactory transduction_Homo sapiens_hsa047401.91390054
19Nucleotide excision repair_Homo sapiens_hsa034201.82820794
20Caffeine metabolism_Homo sapiens_hsa002321.80153753
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79645525
22RNA degradation_Homo sapiens_hsa030181.79636266
23Linoleic acid metabolism_Homo sapiens_hsa005911.77362323
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76350792
25Propanoate metabolism_Homo sapiens_hsa006401.69657282
26Spliceosome_Homo sapiens_hsa030401.63933799
27Huntingtons disease_Homo sapiens_hsa050161.58342679
28RNA polymerase_Homo sapiens_hsa030201.57888742
29Proteasome_Homo sapiens_hsa030501.51308544
30Circadian rhythm_Homo sapiens_hsa047101.51056098
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49896157
32Glycerolipid metabolism_Homo sapiens_hsa005611.47418992
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41133313
34Fatty acid biosynthesis_Homo sapiens_hsa000611.37375235
35Regulation of autophagy_Homo sapiens_hsa041401.36462271
36Base excision repair_Homo sapiens_hsa034101.35639493
37Pyrimidine metabolism_Homo sapiens_hsa002401.35614517
38p53 signaling pathway_Homo sapiens_hsa041151.33475932
39Phototransduction_Homo sapiens_hsa047441.31406752
40Purine metabolism_Homo sapiens_hsa002301.25231739
41Glucagon signaling pathway_Homo sapiens_hsa049221.24968777
42One carbon pool by folate_Homo sapiens_hsa006701.17898171
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16921527
44Nicotine addiction_Homo sapiens_hsa050331.15124494
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.13884397
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06779193
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.96739468
48Taste transduction_Homo sapiens_hsa047420.92591752
49Epstein-Barr virus infection_Homo sapiens_hsa051690.86396244
50Ether lipid metabolism_Homo sapiens_hsa005650.85689953
51Herpes simplex infection_Homo sapiens_hsa051680.85545132
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83088909
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80722299
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.80627527
55Lysine degradation_Homo sapiens_hsa003100.78367551
56Sulfur relay system_Homo sapiens_hsa041220.75765809
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75200759
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75062267
59Biosynthesis of amino acids_Homo sapiens_hsa012300.71381800
60Butanoate metabolism_Homo sapiens_hsa006500.69997882
61mTOR signaling pathway_Homo sapiens_hsa041500.69529119
62HTLV-I infection_Homo sapiens_hsa051660.68890884
63Systemic lupus erythematosus_Homo sapiens_hsa053220.67078730
64Gap junction_Homo sapiens_hsa045400.65222417
65Carbon metabolism_Homo sapiens_hsa012000.61360661
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60632366
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.59776960
68Fat digestion and absorption_Homo sapiens_hsa049750.57892780
69Viral carcinogenesis_Homo sapiens_hsa052030.57478805
70Protein export_Homo sapiens_hsa030600.56782904
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55946660
72PPAR signaling pathway_Homo sapiens_hsa033200.54083426
73Serotonergic synapse_Homo sapiens_hsa047260.53115626
74Tight junction_Homo sapiens_hsa045300.51444241
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51353715
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48716463
77Morphine addiction_Homo sapiens_hsa050320.46568763
78Basal cell carcinoma_Homo sapiens_hsa052170.44388629
79Bile secretion_Homo sapiens_hsa049760.43576404
80GABAergic synapse_Homo sapiens_hsa047270.42389023
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.40890978
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40618873
83Antigen processing and presentation_Homo sapiens_hsa046120.39905038
84Adherens junction_Homo sapiens_hsa045200.38725130
85Glutathione metabolism_Homo sapiens_hsa004800.37091220
86Mineral absorption_Homo sapiens_hsa049780.36248228
87Hedgehog signaling pathway_Homo sapiens_hsa043400.35673554
88Small cell lung cancer_Homo sapiens_hsa052220.33349730
89TGF-beta signaling pathway_Homo sapiens_hsa043500.33066422
90Wnt signaling pathway_Homo sapiens_hsa043100.32772526
91Influenza A_Homo sapiens_hsa051640.32226073
92Arachidonic acid metabolism_Homo sapiens_hsa005900.31788033
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29577998
94Folate biosynthesis_Homo sapiens_hsa007900.28885822
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.28840496
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28536969
97Glutamatergic synapse_Homo sapiens_hsa047240.28314925
98beta-Alanine metabolism_Homo sapiens_hsa004100.28069020
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26556369
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25823610
101Fatty acid metabolism_Homo sapiens_hsa012120.25020791
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24978539
103Synaptic vesicle cycle_Homo sapiens_hsa047210.23381162
104MicroRNAs in cancer_Homo sapiens_hsa052060.22882444
105Hippo signaling pathway_Homo sapiens_hsa043900.22311335
106Metabolic pathways_Homo sapiens_hsa011000.22092231
107ABC transporters_Homo sapiens_hsa020100.21597821
108Inositol phosphate metabolism_Homo sapiens_hsa005620.20085850
109Ovarian steroidogenesis_Homo sapiens_hsa049130.19357901
110cAMP signaling pathway_Homo sapiens_hsa040240.19230813
111Protein digestion and absorption_Homo sapiens_hsa049740.19153742
112Vitamin digestion and absorption_Homo sapiens_hsa049770.18738685
113Long-term depression_Homo sapiens_hsa047300.17556161
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16847303
115Notch signaling pathway_Homo sapiens_hsa043300.16198693
116Circadian entrainment_Homo sapiens_hsa047130.15501038
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15270359
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.15052706
119AMPK signaling pathway_Homo sapiens_hsa041520.14524175
120N-Glycan biosynthesis_Homo sapiens_hsa005100.14292011
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13917131
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13565697
123Prostate cancer_Homo sapiens_hsa052150.13289386
124Fatty acid degradation_Homo sapiens_hsa000710.11935551
125FoxO signaling pathway_Homo sapiens_hsa040680.11617174
126Oxytocin signaling pathway_Homo sapiens_hsa049210.10719910
127Phenylalanine metabolism_Homo sapiens_hsa003600.09911660
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.09745155
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.09283772
130Retinol metabolism_Homo sapiens_hsa008300.08789355
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07876327
132Amphetamine addiction_Homo sapiens_hsa050310.07800227
133Ras signaling pathway_Homo sapiens_hsa040140.07724327
134Pancreatic cancer_Homo sapiens_hsa052120.06818008
135Chemical carcinogenesis_Homo sapiens_hsa052040.06734544
136Pathways in cancer_Homo sapiens_hsa052000.04779003
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04776961
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.03835890
139Tryptophan metabolism_Homo sapiens_hsa003800.03272957
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.02737186
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.02488471
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.02475161
143Calcium signaling pathway_Homo sapiens_hsa040200.01679995
144Fructose and mannose metabolism_Homo sapiens_hsa000510.01658120

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