TOPBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.42713565
2nuclear pore organization (GO:0006999)5.28759347
3DNA unwinding involved in DNA replication (GO:0006268)5.24855450
4protein localization to kinetochore (GO:0034501)5.01745631
5mitotic sister chromatid cohesion (GO:0007064)4.41397301
6DNA replication initiation (GO:0006270)4.36408069
7protein localization to chromosome, centromeric region (GO:0071459)4.28972151
8mitotic chromosome condensation (GO:0007076)4.24467729
9pore complex assembly (GO:0046931)4.23989385
10DNA strand elongation involved in DNA replication (GO:0006271)4.21752725
11sister chromatid segregation (GO:0000819)4.10494208
12kinetochore organization (GO:0051383)4.10379077
13mitotic nuclear envelope disassembly (GO:0007077)4.06317547
14DNA strand elongation (GO:0022616)4.02809706
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99328357
16mitotic sister chromatid segregation (GO:0000070)3.99105249
17telomere maintenance via semi-conservative replication (GO:0032201)3.94757570
18regulation of histone H3-K9 methylation (GO:0051570)3.94608843
19DNA geometric change (GO:0032392)3.89547017
20DNA duplex unwinding (GO:0032508)3.89311291
21mitotic recombination (GO:0006312)3.85422159
22DNA replication-dependent nucleosome organization (GO:0034723)3.80530830
23DNA replication-dependent nucleosome assembly (GO:0006335)3.80530830
24membrane disassembly (GO:0030397)3.78055975
25nuclear envelope disassembly (GO:0051081)3.78055975
26double-strand break repair via nonhomologous end joining (GO:0006303)3.76672726
27non-recombinational repair (GO:0000726)3.76672726
28mitotic metaphase plate congression (GO:0007080)3.76563477
29telomere maintenance via recombination (GO:0000722)3.75236187
30DNA packaging (GO:0006323)3.72224256
31DNA replication checkpoint (GO:0000076)3.72120522
32meiotic chromosome segregation (GO:0045132)3.66601304
33regulation of translational fidelity (GO:0006450)3.66014721
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65376073
35regulation of spindle organization (GO:0090224)3.57410872
36metaphase plate congression (GO:0051310)3.54547875
37IMP biosynthetic process (GO:0006188)3.54172818
38positive regulation of chromosome segregation (GO:0051984)3.52108127
39regulation of nucleobase-containing compound transport (GO:0032239)3.51061021
40chromatin remodeling at centromere (GO:0031055)3.50675634
41regulation of DNA endoreduplication (GO:0032875)3.48744847
42CENP-A containing nucleosome assembly (GO:0034080)3.44266751
43ribosome assembly (GO:0042255)3.42316103
44heterochromatin organization (GO:0070828)3.41995225
45attachment of spindle microtubules to kinetochore (GO:0008608)3.41367044
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39711616
47translesion synthesis (GO:0019985)3.39378990
48DNA replication-independent nucleosome organization (GO:0034724)3.37214424
49DNA replication-independent nucleosome assembly (GO:0006336)3.37214424
50establishment of integrated proviral latency (GO:0075713)3.36211351
51V(D)J recombination (GO:0033151)3.36132837
52negative regulation of histone methylation (GO:0031061)3.34786052
53regulation of centriole replication (GO:0046599)3.33542137
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.31810781
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31810781
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31810781
57formation of translation preinitiation complex (GO:0001731)3.31189002
58protein K6-linked ubiquitination (GO:0085020)3.30743309
59kinetochore assembly (GO:0051382)3.30382149
60regulation of sister chromatid cohesion (GO:0007063)3.30065611
61chromatin assembly or disassembly (GO:0006333)3.28235628
62dosage compensation (GO:0007549)3.27933797
63telomere maintenance via telomere lengthening (GO:0010833)3.27636001
64sister chromatid cohesion (GO:0007062)3.27537772
65pre-miRNA processing (GO:0031054)3.26709833
66protein localization to chromosome (GO:0034502)3.26671247
67DNA conformation change (GO:0071103)3.26637864
68chromatin assembly (GO:0031497)3.26075172
69folic acid-containing compound biosynthetic process (GO:0009396)3.24919240
70negative regulation of DNA repair (GO:0045738)3.23792891
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.22380511
72DNA ligation (GO:0006266)3.22016571
73regulation of mitotic spindle organization (GO:0060236)3.21989751
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.21279769
75establishment of chromosome localization (GO:0051303)3.20465837
76regulation of centrosome duplication (GO:0010824)3.20025161
77regulation of RNA export from nucleus (GO:0046831)3.18406199
78DNA topological change (GO:0006265)3.18079006
79regulation of chromosome segregation (GO:0051983)3.13807567
80regulation of centrosome cycle (GO:0046605)3.12720017
81protein export from nucleus (GO:0006611)3.11904230
82IMP metabolic process (GO:0046040)3.11352347
83negative regulation of mRNA processing (GO:0050686)3.10669868
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.09682771
85nucleobase biosynthetic process (GO:0046112)3.08826626
86mRNA transport (GO:0051028)3.06813048
87spindle checkpoint (GO:0031577)3.06593408
88mRNA stabilization (GO:0048255)3.04562516
89RNA stabilization (GO:0043489)3.04562516
90regulation of nuclear cell cycle DNA replication (GO:0033262)3.04470174
91histone exchange (GO:0043486)3.04093906
92positive regulation of cell cycle checkpoint (GO:1901978)3.03323939
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01627176
94chromosome segregation (GO:0007059)3.01015184
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00086047
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99849336
97regulation of histone H3-K27 methylation (GO:0061085)2.98604450
98chromosome condensation (GO:0030261)2.98494148
99spindle assembly checkpoint (GO:0071173)2.98099158
100negative regulation of mRNA metabolic process (GO:1903312)2.97981781
101nuclear envelope organization (GO:0006998)2.95951666
102telomere maintenance (GO:0000723)2.94991002
103regulation of helicase activity (GO:0051095)2.94292252
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.93717842
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93717842
106negative regulation of chromosome segregation (GO:0051985)2.93070433
107ATP-dependent chromatin remodeling (GO:0043044)2.92344994
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92302077
109telomere organization (GO:0032200)2.91910229
110DNA synthesis involved in DNA repair (GO:0000731)2.88646599
111postreplication repair (GO:0006301)2.88444913
112mitotic spindle checkpoint (GO:0071174)2.87885589
113negative regulation of sister chromatid segregation (GO:0033046)2.87332988
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.87332988
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87332988
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87332988
117negative regulation of RNA splicing (GO:0033119)2.86185704
118mitotic spindle assembly checkpoint (GO:0007094)2.86009871
119mismatch repair (GO:0006298)2.85477092
120regulation of sister chromatid segregation (GO:0033045)2.85123131
121regulation of mitotic sister chromatid separation (GO:0010965)2.85123131
122regulation of mitotic sister chromatid segregation (GO:0033047)2.85123131
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84120555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.81888734
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.64436739
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62092501
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.49005187
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.26305416
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62777909
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61933315
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49755693
9* E2F1_21310950_ChIP-Seq_MCF-7_Human2.47633785
10AR_21909140_ChIP-Seq_LNCAP_Human2.44195370
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37160028
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14584209
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11978901
14MYC_22102868_ChIP-Seq_BL_Human2.11716281
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11209372
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02132110
17E2F7_22180533_ChIP-Seq_HELA_Human11.6576316
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95192113
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.86488524
20XRN2_22483619_ChIP-Seq_HELA_Human1.83606862
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.82607010
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.81368119
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75798133
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70115920
25* VDR_23849224_ChIP-Seq_CD4+_Human1.69036032
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68575566
27CIITA_25753668_ChIP-Seq_RAJI_Human1.66202872
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.61639269
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61282429
30FOXP3_21729870_ChIP-Seq_TREG_Human1.59553026
31* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52060664
32ELK1_19687146_ChIP-ChIP_HELA_Human1.51489823
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51049449
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49386340
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48768703
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48411394
37* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47932079
38TTF2_22483619_ChIP-Seq_HELA_Human1.47755590
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47708601
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47554271
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46841169
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43484925
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39690713
44KDM5A_27292631_Chip-Seq_BREAST_Human1.39678466
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39452429
46* GABP_17652178_ChIP-ChIP_JURKAT_Human1.38547496
47VDR_21846776_ChIP-Seq_THP-1_Human1.32983781
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32582165
49DCP1A_22483619_ChIP-Seq_HELA_Human1.30113065
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29771084
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26950701
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26245859
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25872872
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21943091
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19904119
56* GABP_19822575_ChIP-Seq_HepG2_Human1.19118936
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17143447
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16145226
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15729413
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14772273
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13540731
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13116812
63TFEB_21752829_ChIP-Seq_HELA_Human1.08776053
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07478387
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05979115
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05457554
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04371761
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01967202
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01462777
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01243092
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01131756
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98648360
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97869973
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97817544
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97806456
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97237402
77* SPI1_23547873_ChIP-Seq_NB4_Human0.97161976
78MYB_26560356_Chip-Seq_TH1_Human0.96508599
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95529815
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95501011
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93968920
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91829253
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91829253
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91829253
85MYB_26560356_Chip-Seq_TH2_Human0.91740218
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91654034
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88885352
88* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87993679
89NANOG_21062744_ChIP-ChIP_HESCs_Human0.87456458
90UTX_26944678_Chip-Seq_JUKART_Human0.86831586
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.84814580
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.84704242
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84496187
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83289590
95MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82843711
96TCF7_22412390_ChIP-Seq_EML_Mouse0.82497251
97MAF_26560356_Chip-Seq_TH1_Human0.82411258
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81533687
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81244643
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81047278
101GATA1_22025678_ChIP-Seq_K562_Human0.80805214
102ZNF263_19887448_ChIP-Seq_K562_Human0.80532814
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80406713
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79361688
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78388391
106SCL_19346495_ChIP-Seq_HPC-7_Human0.78337489
107* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77463333
108MYC_18940864_ChIP-ChIP_HL60_Human0.76846653
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76612832
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76338789
111CHD1_26751641_Chip-Seq_LNCaP_Human0.75935712
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75130510
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75000116
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74391621
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73231007
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71320759
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69943557
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68212067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.37443289
2MP0003111_abnormal_nucleus_morphology4.12955714
3MP0008057_abnormal_DNA_replication4.09875541
4MP0003693_abnormal_embryo_hatching4.08939441
5MP0003077_abnormal_cell_cycle3.53044438
6MP0004957_abnormal_blastocyst_morpholog3.40055328
7MP0002009_preneoplasia3.18503879
8MP0008058_abnormal_DNA_repair2.76680278
9MP0010352_gastrointestinal_tract_polyps2.66875120
10MP0002396_abnormal_hematopoietic_system2.62989711
11MP0010307_abnormal_tumor_latency2.54724134
12MP0008007_abnormal_cellular_replicative2.41405398
13MP0008932_abnormal_embryonic_tissue2.13567292
14MP0008877_abnormal_DNA_methylation2.12493393
15MP0000350_abnormal_cell_proliferation2.12367662
16MP0001730_embryonic_growth_arrest2.10961790
17MP0004185_abnormal_adipocyte_glucose1.94323577
18MP0005076_abnormal_cell_differentiation1.93141794
19MP0004808_abnormal_hematopoietic_stem1.92256951
20MP0003123_paternal_imprinting1.81638840
21MP0001672_abnormal_embryogenesis/_devel1.73421442
22MP0005380_embryogenesis_phenotype1.73421442
23MP0009697_abnormal_copulation1.68611665
24MP0000490_abnormal_crypts_of1.67074989
25MP0010234_abnormal_vibrissa_follicle1.64396136
26MP0003121_genomic_imprinting1.63735521
27MP0004197_abnormal_fetal_growth/weight/1.62410910
28MP0003786_premature_aging1.61129859
29MP0003984_embryonic_growth_retardation1.58346658
30MP0001697_abnormal_embryo_size1.57702537
31MP0002084_abnormal_developmental_patter1.56146351
32MP0002088_abnormal_embryonic_growth/wei1.55153519
33MP0002085_abnormal_embryonic_tissue1.53830113
34MP0009278_abnormal_bone_marrow1.53205125
35MP0002086_abnormal_extraembryonic_tissu1.50667292
36MP0004233_abnormal_muscle_weight1.46827977
37MP0003705_abnormal_hypodermis_morpholog1.42907667
38MP0003567_abnormal_fetal_cardiomyocyte1.42375745
39MP0002080_prenatal_lethality1.41943948
40MP0002019_abnormal_tumor_incidence1.34526368
41MP0000703_abnormal_thymus_morphology1.32985706
42MP0005397_hematopoietic_system_phenotyp1.31989781
43MP0001545_abnormal_hematopoietic_system1.31989781
44MP0000569_abnormal_digit_pigmentation1.31021292
45MP0000313_abnormal_cell_death1.30289068
46MP0003763_abnormal_thymus_physiology1.24931671
47MP0003890_abnormal_embryonic-extraembry1.22551809
48MP0001293_anophthalmia1.21061129
49MP0002398_abnormal_bone_marrow1.20111671
50MP0003221_abnormal_cardiomyocyte_apopto1.20077187
51MP0004264_abnormal_extraembryonic_tissu1.18964668
52MP0000537_abnormal_urethra_morphology1.14067601
53MP0002722_abnormal_immune_system1.08001951
54MP0003937_abnormal_limbs/digits/tail_de1.07156366
55MP0003943_abnormal_hepatobiliary_system1.07016781
56MP0002210_abnormal_sex_determination1.05435815
57MP0003566_abnormal_cell_adhesion1.03728115
58MP0010030_abnormal_orbit_morphology1.02242352
59MP0000383_abnormal_hair_follicle1.00496336
60MP0000689_abnormal_spleen_morphology0.99815364
61MP0000733_abnormal_muscle_development0.99669559
62MP0005451_abnormal_body_composition0.98051592
63MP0009703_decreased_birth_body0.97253398
64MP0001915_intracranial_hemorrhage0.96512710
65MP0009333_abnormal_splenocyte_physiolog0.95628804
66MP0003787_abnormal_imprinting0.92674292
67MP0000428_abnormal_craniofacial_morphol0.91992598
68MP0006054_spinal_hemorrhage0.91768801
69MP0001145_abnormal_male_reproductive0.91568318
70MP0003941_abnormal_skin_development0.90588262
71MP0002092_abnormal_eye_morphology0.89572187
72MP0005501_abnormal_skin_physiology0.89006230
73MP0009672_abnormal_birth_weight0.88645147
74MP0005023_abnormal_wound_healing0.87176571
75MP0000432_abnormal_head_morphology0.85670861
76MP0002166_altered_tumor_susceptibility0.85162832
77MP0001800_abnormal_humoral_immune0.84710058
78MP0002006_tumorigenesis0.84289917
79MP0002429_abnormal_blood_cell0.83793041
80MP0009053_abnormal_anal_canal0.83247983
81MP0001727_abnormal_embryo_implantation0.83021175
82MP0005174_abnormal_tail_pigmentation0.82733650
83MP0002111_abnormal_tail_morphology0.82458279
84MP0005621_abnormal_cell_physiology0.81059490
85MP0001346_abnormal_lacrimal_gland0.80456113
86MP0000716_abnormal_immune_system0.80306078
87MP0002796_impaired_skin_barrier0.79864122
88MP0010678_abnormal_skin_adnexa0.79843766
89MP0002697_abnormal_eye_size0.79586937
90MP0005409_darkened_coat_color0.78283748
91MP0001929_abnormal_gametogenesis0.77549163
92MP0000358_abnormal_cell_content/0.77250306
93MP0001661_extended_life_span0.77212611
94MP0003656_abnormal_erythrocyte_physiolo0.76165508
95MP0002877_abnormal_melanocyte_morpholog0.75865049
96MP0005384_cellular_phenotype0.74924103
97MP0003935_abnormal_craniofacial_develop0.74812062
98MP0000653_abnormal_sex_gland0.73895284
99MP0000858_altered_metastatic_potential0.73479895
100MP0002925_abnormal_cardiovascular_devel0.73450837
101MP0001286_abnormal_eye_development0.73301159
102MP0002095_abnormal_skin_pigmentation0.73200869
103MP0003448_altered_tumor_morphology0.71694543
104MP0002452_abnormal_antigen_presenting0.70780750
105MP0005666_abnormal_adipose_tissue0.69520576
106MP0002075_abnormal_coat/hair_pigmentati0.69509053
107MP0003718_maternal_effect0.69401088
108MP0002420_abnormal_adaptive_immunity0.68301612
109MP0003315_abnormal_perineum_morphology0.67706448
110MP0003300_gastrointestinal_ulcer0.67031953
111MP0001819_abnormal_immune_cell0.66959158
112MP0000477_abnormal_intestine_morphology0.65746219
113MP0003115_abnormal_respiratory_system0.65651273
114MP0003385_abnormal_body_wall0.65230722
115MP0000465_gastrointestinal_hemorrhage0.64900628
116MP0000627_abnormal_mammary_gland0.63677140
117MP0002405_respiratory_system_inflammati0.63629020
118MP0000371_diluted_coat_color0.62832685
119MP0001119_abnormal_female_reproductive0.61502583
120MP0000377_abnormal_hair_follicle0.61370256
121MP0003119_abnormal_digestive_system0.61253384
122MP0003861_abnormal_nervous_system0.61220514
123MP0002098_abnormal_vibrissa_morphology0.59285709
124MP0001216_abnormal_epidermal_layer0.57900725
125MP0008260_abnormal_autophagy0.57364438
126MP0010630_abnormal_cardiac_muscle0.55932841
127MP0002060_abnormal_skin_morphology0.55850243
128MP0006035_abnormal_mitochondrial_morpho0.55812467
129MP0003699_abnormal_female_reproductive0.55095788

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.62858188
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36179963
3Abnormality of chromosome stability (HP:0003220)3.47428222
4Volvulus (HP:0002580)3.42533261
5Birth length less than 3rd percentile (HP:0003561)3.25271377
6Reticulocytopenia (HP:0001896)3.09456338
7Medulloblastoma (HP:0002885)3.02141804
8Ectopic kidney (HP:0000086)2.98615283
9Ependymoma (HP:0002888)2.96289379
10Selective tooth agenesis (HP:0001592)2.95808678
11Increased nuchal translucency (HP:0010880)2.91306143
12Meckel diverticulum (HP:0002245)2.90188839
13Abnormality of the preputium (HP:0100587)2.84335093
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.82527238
15Abnormality of the ileum (HP:0001549)2.75581807
16Colon cancer (HP:0003003)2.72917674
17Insidious onset (HP:0003587)2.72290105
18Termporal pattern (HP:0011008)2.72290105
19Proximal placement of thumb (HP:0009623)2.70447376
20Deviation of the thumb (HP:0009603)2.67354962
21Impulsivity (HP:0100710)2.65744569
22Myelodysplasia (HP:0002863)2.64192183
23Asymmetry of the thorax (HP:0001555)2.62627126
24Short 4th metacarpal (HP:0010044)2.60581958
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60581958
26Duplicated collecting system (HP:0000081)2.51887633
27Duodenal stenosis (HP:0100867)2.50546378
28Small intestinal stenosis (HP:0012848)2.50546378
29Cortical dysplasia (HP:0002539)2.49139430
30Rhabdomyosarcoma (HP:0002859)2.42093536
31Progressive external ophthalmoplegia (HP:0000590)2.42089358
32Abnormality of the fingertips (HP:0001211)2.40728041
33Patellar aplasia (HP:0006443)2.38368725
34Microvesicular hepatic steatosis (HP:0001414)2.37696066
35Prominent nose (HP:0000448)2.36569307
36Abnormality of the carotid arteries (HP:0005344)2.36278404
37Abnormality of chromosome segregation (HP:0002916)2.36257447
38Agnosia (HP:0010524)2.34076670
39Breast hypoplasia (HP:0003187)2.32424488
40Basal cell carcinoma (HP:0002671)2.29473086
41Glioma (HP:0009733)2.27619894
42Astrocytoma (HP:0009592)2.27377023
43Abnormality of the astrocytes (HP:0100707)2.27377023
44Leiomyosarcoma (HP:0100243)2.26520135
45Uterine leiomyosarcoma (HP:0002891)2.26520135
46Embryonal neoplasm (HP:0002898)2.26044585
47High pitched voice (HP:0001620)2.25466522
48Absent thumb (HP:0009777)2.24052702
49Abnormality of the renal collecting system (HP:0004742)2.23131297
50Aplasia/Hypoplasia of the patella (HP:0006498)2.22640680
51Transitional cell carcinoma of the bladder (HP:0006740)2.20592648
52Abnormality of the labia minora (HP:0012880)2.19577589
53Ankyloglossia (HP:0010296)2.17644401
54High anterior hairline (HP:0009890)2.17252547
5511 pairs of ribs (HP:0000878)2.15481474
56Long eyelashes (HP:0000527)2.14753094
57Absent radius (HP:0003974)2.14715805
58Abnormal number of incisors (HP:0011064)2.14618970
59Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.14248240
60Sloping forehead (HP:0000340)2.14183647
61Facial hemangioma (HP:0000329)2.11549271
62Abnormality of DNA repair (HP:0003254)2.11535324
63Cafe-au-lait spot (HP:0000957)2.08134164
64Bladder carcinoma (HP:0002862)2.05846068
65Bladder neoplasm (HP:0009725)2.05846068
66Abnormality of the duodenum (HP:0002246)2.05770158
67Atresia of the external auditory canal (HP:0000413)2.05396530
68Papillary thyroid carcinoma (HP:0002895)2.04445793
69Obsessive-compulsive behavior (HP:0000722)2.04327476
70Clubbing of toes (HP:0100760)2.03737472
71Neoplasm of the oral cavity (HP:0100649)2.02860818
72Bone marrow hypocellularity (HP:0005528)2.01358727
73Short thumb (HP:0009778)2.01279389
74Deep philtrum (HP:0002002)2.00099161
75Aplasia involving forearm bones (HP:0009822)1.99272885
76Absent forearm bone (HP:0003953)1.99272885
77Subacute progressive viral hepatitis (HP:0006572)1.96946705
78Deep palmar crease (HP:0006191)1.95200439
79Squamous cell carcinoma (HP:0002860)1.93565736
80Neoplasm of the pancreas (HP:0002894)1.93354545
81Neoplasm of striated muscle (HP:0009728)1.92474869
82Tracheoesophageal fistula (HP:0002575)1.91731428
83Insomnia (HP:0100785)1.90818966
84Nephroblastoma (Wilms tumor) (HP:0002667)1.90786639
85Syringomyelia (HP:0003396)1.90778512
86Spinal cord lesions (HP:0100561)1.90778512
87Relative macrocephaly (HP:0004482)1.90282119
88Abnormal lung lobation (HP:0002101)1.88798445
89Malignant gastrointestinal tract tumors (HP:0006749)1.88719663
90Gastrointestinal carcinoma (HP:0002672)1.88719663
91Amaurosis fugax (HP:0100576)1.88489183
92Abnormality of cells of the erythroid lineage (HP:0012130)1.87694662
93Overlapping toe (HP:0001845)1.86962515
94Viral hepatitis (HP:0006562)1.86361531
95Acute myeloid leukemia (HP:0004808)1.84523311
96Multiple enchondromatosis (HP:0005701)1.82020580
97Increased density of long bones (HP:0006392)1.81824282
98Missing ribs (HP:0000921)1.81429576
99Biliary tract neoplasm (HP:0100574)1.80808987
100Lymphoma (HP:0002665)1.80471277
101Hyperacusis (HP:0010780)1.79748894
102Skull defect (HP:0001362)1.79004993
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.78834774
104Supernumerary ribs (HP:0005815)1.78558937
105Choanal atresia (HP:0000453)1.78541249
106Abnormality of oral frenula (HP:0000190)1.77952419
107Abnormal foot bone ossification (HP:0010675)1.77587955
108Cystic hygroma (HP:0000476)1.77564401
109Abnormal number of erythroid precursors (HP:0012131)1.76471262
110Embryonal renal neoplasm (HP:0011794)1.75431177
111Capillary hemangiomas (HP:0005306)1.74716465
112Progressive muscle weakness (HP:0003323)1.73755186
113Supernumerary bones of the axial skeleton (HP:0009144)1.73514295
114Cutaneous melanoma (HP:0012056)1.73441093
115Acute lymphatic leukemia (HP:0006721)1.70727078
116Cutis marmorata (HP:0000965)1.70261083
117Sandal gap (HP:0001852)1.69509433
118Supernumerary spleens (HP:0009799)1.69316324
119Heterotopia (HP:0002282)1.69212066
120IgM deficiency (HP:0002850)1.69062627
121Abnormality of the 4th metacarpal (HP:0010012)1.67839740
122Overriding aorta (HP:0002623)1.67363580
123Sparse lateral eyebrow (HP:0005338)1.66618490
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66587451
125Premature graying of hair (HP:0002216)1.66118052
126Neoplasm of the colon (HP:0100273)1.64539890
127Abnormality of the anterior horn cell (HP:0006802)1.64390986
128Degeneration of anterior horn cells (HP:0002398)1.64390986
129Recurrent viral infections (HP:0004429)1.64084115
130Blepharitis (HP:0000498)1.63954634
131B lymphocytopenia (HP:0010976)1.63924918
132Neoplasm of the adrenal cortex (HP:0100641)1.62866326
133Microtia (HP:0008551)1.62728186
134Abnormality of the calcaneus (HP:0008364)1.62152536
135Poikiloderma (HP:0001029)1.61811036
136Arteriovenous malformation (HP:0100026)1.61388453
137Dysmetric saccades (HP:0000641)1.61093546
138Urethral obstruction (HP:0000796)1.61008668
139Low anterior hairline (HP:0000294)1.60282100
140Pallor (HP:0000980)1.59913606
141Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59703639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.94118459
2CDK123.40089022
3WEE13.33834030
4NEK23.33696688
5EEF2K2.80001262
6BUB12.60609487
7TTK2.58743328
8SRPK12.41348609
9SMG12.39775656
10ATR2.08363973
11PLK42.00413743
12MKNK11.95074811
13BRD41.89720691
14RPS6KB21.87519872
15PASK1.80941284
16PLK11.78921594
17CDK41.78267123
18ZAK1.77822625
19PRPF4B1.75962336
20PBK1.72691564
21MAP3K101.72684084
22AURKB1.71648855
23TSSK61.65700443
24STK101.64935497
25CDK71.62303201
26PKN21.61995773
27CHEK21.60141113
28STK41.56738624
29MKNK21.55987703
30CHEK11.52315158
31PLK31.51424230
32BRSK21.46154792
33ACVR1B1.45776439
34ICK1.44047344
35SCYL21.44012063
36TLK11.41820695
37STK31.41013435
38RPS6KA41.39422527
39MAP3K81.35916541
40CDK61.32986333
41MAP4K11.32795867
42TAF11.32511167
43DYRK31.29129768
44* ATM1.23202649
45NEK11.19479092
46EPHA21.17679650
47EIF2AK11.15508372
48VRK11.12954798
49CAMK1G1.11380155
50PIM11.07859316
51TGFBR11.06690111
52LATS10.99663051
53* CDK20.99499343
54ALK0.99274038
55MELK0.91491899
56CLK10.87723834
57MTOR0.86343734
58PAK40.85376861
59KSR20.84967513
60TTN0.83918309
61BRAF0.82426436
62CDK10.79387596
63MAP3K140.78287302
64AURKA0.77102214
65KSR10.76266723
66CAMK1D0.75661275
67FLT30.73587094
68TESK20.73054055
69RAF10.72497989
70IRAK30.72462948
71BRSK10.69813016
72LRRK20.65725440
73PNCK0.64300780
74NME20.63089856
75EIF2AK30.62371487
76BTK0.62264028
77JAK30.61485467
78RPS6KA50.60273677
79PAK20.59597511
80SIK30.59390205
81CDK90.58596838
82MAP2K30.58387349
83MAPK110.57394399
84MST1R0.56274121
85PDK20.56212794
86CSNK1D0.56106838
87PRKDC0.54765950
88PTK60.53308233
89CSNK2A20.52736518
90LATS20.51779286
91IRAK40.51230635
92CCNB10.51137677
93FGFR40.50056243
94GRK60.49331607
95NEK90.49081840
96CSF1R0.48836942
97CDK30.48419589
98YES10.47614482
99RPS6KB10.47308556
100MAPK140.46502795
101EIF2AK20.46220611
102NEK60.43997253
103NUAK10.43337452
104MAP3K20.43213476
105TRPM70.42142037
106IRAK20.41553201
107MAP3K130.41517356
108CSNK2A10.40560860
109CSNK1E0.39658301
110FGFR30.39385669
111AKT20.39240583
112TEC0.39022786
113FGFR10.38965498
114CHUK0.38164645
115* AKT10.34505544
116MARK30.33888095
117ZAP700.33207230
118PAK10.33180389
119PRKCI0.32791664
120MAPK10.32618161
121CDK80.31178206
122MAPK100.29713869
123PDGFRA0.29697423
124GSK3B0.29398292
125STK160.28571772
126TRIB30.28542832
127BMX0.28342401
128BCR0.25193602
129CDK180.23655424
130MAP3K90.23186645
131CDK11A0.22632359
132CDK150.22347784

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56425034
2Mismatch repair_Homo sapiens_hsa034303.88833093
3Cell cycle_Homo sapiens_hsa041103.02868438
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01222257
5Homologous recombination_Homo sapiens_hsa034402.88206160
6Spliceosome_Homo sapiens_hsa030402.87899212
7RNA transport_Homo sapiens_hsa030132.84822974
8Base excision repair_Homo sapiens_hsa034102.74368863
9Fanconi anemia pathway_Homo sapiens_hsa034602.70817613
10One carbon pool by folate_Homo sapiens_hsa006702.55711813
11Nucleotide excision repair_Homo sapiens_hsa034202.52080827
12Non-homologous end-joining_Homo sapiens_hsa034502.45438511
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14518157
14mRNA surveillance pathway_Homo sapiens_hsa030152.01191991
15Ribosome_Homo sapiens_hsa030101.85986677
16Systemic lupus erythematosus_Homo sapiens_hsa053221.83642244
17RNA polymerase_Homo sapiens_hsa030201.76944331
18p53 signaling pathway_Homo sapiens_hsa041151.75304729
19RNA degradation_Homo sapiens_hsa030181.72517884
20Pyrimidine metabolism_Homo sapiens_hsa002401.57274043
21Viral carcinogenesis_Homo sapiens_hsa052031.46762151
22Basal transcription factors_Homo sapiens_hsa030221.45487820
23MicroRNAs in cancer_Homo sapiens_hsa052061.29977789
24Herpes simplex infection_Homo sapiens_hsa051681.29272267
25Small cell lung cancer_Homo sapiens_hsa052221.25506049
26Antigen processing and presentation_Homo sapiens_hsa046121.22631036
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20475858
28Epstein-Barr virus infection_Homo sapiens_hsa051691.19605835
29HTLV-I infection_Homo sapiens_hsa051661.18482669
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13042796
31Primary immunodeficiency_Homo sapiens_hsa053401.10928502
32Glioma_Homo sapiens_hsa052141.09611300
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.04555760
34Proteasome_Homo sapiens_hsa030501.04301610
35Chronic myeloid leukemia_Homo sapiens_hsa052201.03097466
36Renal cell carcinoma_Homo sapiens_hsa052111.03010192
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02287738
38Measles_Homo sapiens_hsa051620.89764050
39Oocyte meiosis_Homo sapiens_hsa041140.87550306
40Biosynthesis of amino acids_Homo sapiens_hsa012300.85389147
41Hepatitis B_Homo sapiens_hsa051610.82435058
42Colorectal cancer_Homo sapiens_hsa052100.80018857
43ErbB signaling pathway_Homo sapiens_hsa040120.78847473
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78481215
45Notch signaling pathway_Homo sapiens_hsa043300.78372503
46Lysine degradation_Homo sapiens_hsa003100.78115114
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76424029
48Alcoholism_Homo sapiens_hsa050340.75804603
49Apoptosis_Homo sapiens_hsa042100.75620414
50Purine metabolism_Homo sapiens_hsa002300.74339441
51TGF-beta signaling pathway_Homo sapiens_hsa043500.74334209
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73588896
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73199927
54Viral myocarditis_Homo sapiens_hsa054160.72115154
55B cell receptor signaling pathway_Homo sapiens_hsa046620.71222505
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71175336
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71089719
58Hematopoietic cell lineage_Homo sapiens_hsa046400.70741013
59Thyroid cancer_Homo sapiens_hsa052160.70277130
60Adherens junction_Homo sapiens_hsa045200.69351533
61Basal cell carcinoma_Homo sapiens_hsa052170.67976775
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67798692
63Prostate cancer_Homo sapiens_hsa052150.66930560
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65744854
65Legionellosis_Homo sapiens_hsa051340.62477010
66Hippo signaling pathway_Homo sapiens_hsa043900.61808131
67Pancreatic cancer_Homo sapiens_hsa052120.61282559
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.60885250
69Inositol phosphate metabolism_Homo sapiens_hsa005620.60806834
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60672574
71Leishmaniasis_Homo sapiens_hsa051400.59893838
72Influenza A_Homo sapiens_hsa051640.59626626
73Shigellosis_Homo sapiens_hsa051310.59287162
74Non-small cell lung cancer_Homo sapiens_hsa052230.59278176
75Pathways in cancer_Homo sapiens_hsa052000.58940210
76Acute myeloid leukemia_Homo sapiens_hsa052210.57155764
77T cell receptor signaling pathway_Homo sapiens_hsa046600.55535428
78Prolactin signaling pathway_Homo sapiens_hsa049170.54908298
79Toxoplasmosis_Homo sapiens_hsa051450.53835771
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53036817
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52765942
82Carbon metabolism_Homo sapiens_hsa012000.52463363
83Proteoglycans in cancer_Homo sapiens_hsa052050.51895606
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.51535229
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.50988071
86N-Glycan biosynthesis_Homo sapiens_hsa005100.50593066
87mTOR signaling pathway_Homo sapiens_hsa041500.50317065
88VEGF signaling pathway_Homo sapiens_hsa043700.50117382
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49738404
90Insulin signaling pathway_Homo sapiens_hsa049100.48176849
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.47841008
92Selenocompound metabolism_Homo sapiens_hsa004500.47300855
93Choline metabolism in cancer_Homo sapiens_hsa052310.47235599
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46501808
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.44351199
96Bladder cancer_Homo sapiens_hsa052190.43473368
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.42891054
98FoxO signaling pathway_Homo sapiens_hsa040680.40545074
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40520362
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38897764
101HIF-1 signaling pathway_Homo sapiens_hsa040660.38265981
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37873452
103Osteoclast differentiation_Homo sapiens_hsa043800.36840300
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36615531
105Endometrial cancer_Homo sapiens_hsa052130.36471678
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36459369
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36377703
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36259860
109Estrogen signaling pathway_Homo sapiens_hsa049150.36243525
110TNF signaling pathway_Homo sapiens_hsa046680.35845360
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35705547
112Hedgehog signaling pathway_Homo sapiens_hsa043400.35554121
113AMPK signaling pathway_Homo sapiens_hsa041520.35391777
114Melanoma_Homo sapiens_hsa052180.35134696
115Wnt signaling pathway_Homo sapiens_hsa043100.35016458
116Pentose phosphate pathway_Homo sapiens_hsa000300.34010166
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33937100
118Hepatitis C_Homo sapiens_hsa051600.33532153
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33420649
120Focal adhesion_Homo sapiens_hsa045100.32479615
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.29990521
122ECM-receptor interaction_Homo sapiens_hsa045120.29846360
123Asthma_Homo sapiens_hsa053100.29170297
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28813383

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