TOPORS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.40583552
2nuclear pore organization (GO:0006999)5.19285114
3centriole replication (GO:0007099)4.60115780
4protein localization to kinetochore (GO:0034501)4.33153683
5mitotic metaphase plate congression (GO:0007080)4.28189581
6pore complex assembly (GO:0046931)4.19892593
7DNA unwinding involved in DNA replication (GO:0006268)4.18781501
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.16293221
9DNA replication initiation (GO:0006270)3.99696767
10RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.96881440
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.96169735
12regulation of mitotic spindle checkpoint (GO:1903504)3.96169735
13DNA replication-dependent nucleosome assembly (GO:0006335)3.96044820
14DNA replication-dependent nucleosome organization (GO:0034723)3.96044820
15mitotic nuclear envelope disassembly (GO:0007077)3.93088564
16regulation of spindle organization (GO:0090224)3.87946995
17metaphase plate congression (GO:0051310)3.83796827
18mitotic chromosome condensation (GO:0007076)3.81949014
19chromatin remodeling at centromere (GO:0031055)3.78016113
20regulation of histone H3-K9 methylation (GO:0051570)3.76860338
21protein localization to chromosome, centromeric region (GO:0071459)3.76341745
22DNA double-strand break processing (GO:0000729)3.72072893
23membrane disassembly (GO:0030397)3.67408571
24nuclear envelope disassembly (GO:0051081)3.67408571
25CENP-A containing nucleosome assembly (GO:0034080)3.67120833
26replication fork processing (GO:0031297)3.66325009
27DNA replication checkpoint (GO:0000076)3.63599869
28regulation of posttranscriptional gene silencing (GO:0060147)3.63149225
29regulation of gene silencing by miRNA (GO:0060964)3.63149225
30regulation of gene silencing by RNA (GO:0060966)3.63149225
31regulation of DNA endoreduplication (GO:0032875)3.62819339
32mitotic sister chromatid cohesion (GO:0007064)3.62133230
33positive regulation of chromosome segregation (GO:0051984)3.60974933
34folic acid-containing compound biosynthetic process (GO:0009396)3.58136240
35regulation of helicase activity (GO:0051095)3.57991600
36kinetochore organization (GO:0051383)3.57824383
37DNA strand elongation involved in DNA replication (GO:0006271)3.57587346
38nucleobase biosynthetic process (GO:0046112)3.57319573
39regulation of RNA export from nucleus (GO:0046831)3.56373179
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53777356
41purine nucleobase biosynthetic process (GO:0009113)3.49503950
42DNA replication-independent nucleosome assembly (GO:0006336)3.48554388
43DNA replication-independent nucleosome organization (GO:0034724)3.48554388
44ribosome assembly (GO:0042255)3.48252361
45protein polyglutamylation (GO:0018095)3.45188473
46regulation of meiosis I (GO:0060631)3.44920348
47negative regulation of DNA recombination (GO:0045910)3.43571276
48histone exchange (GO:0043486)3.43365932
49maturation of SSU-rRNA (GO:0030490)3.42925952
50histone mRNA catabolic process (GO:0071044)3.42464224
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.41291193
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.41291193
53isotype switching (GO:0045190)3.41291193
54protein K6-linked ubiquitination (GO:0085020)3.40987484
55negative regulation of histone methylation (GO:0031061)3.39904570
56DNA duplex unwinding (GO:0032508)3.37633797
57DNA geometric change (GO:0032392)3.37140364
58DNA strand elongation (GO:0022616)3.36757304
59histone mRNA metabolic process (GO:0008334)3.36729519
60single strand break repair (GO:0000012)3.36284891
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34795694
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34795694
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.34795694
64mitotic G2 DNA damage checkpoint (GO:0007095)3.34565541
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33753514
66regulation of mitotic spindle organization (GO:0060236)3.32335132
67meiotic chromosome segregation (GO:0045132)3.29240293
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29145451
69negative regulation of translation, ncRNA-mediated (GO:0040033)3.28505368
70regulation of translation, ncRNA-mediated (GO:0045974)3.28505368
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28505368
72formation of translation preinitiation complex (GO:0001731)3.25415568
73establishment of chromosome localization (GO:0051303)3.23785597
74regulation of sister chromatid cohesion (GO:0007063)3.23661754
75regulation of DNA methylation (GO:0044030)3.20848693
76IMP biosynthetic process (GO:0006188)3.19040920
77postreplication repair (GO:0006301)3.18980625
78chromatin assembly (GO:0031497)3.18095948
79mitotic sister chromatid segregation (GO:0000070)3.15938367
80maturation of 5.8S rRNA (GO:0000460)3.15272305
81chromatin assembly or disassembly (GO:0006333)3.15231796
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14809921
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.14792117
84regulation of chromosome segregation (GO:0051983)3.14778723
85negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.14191861
86DNA-dependent DNA replication (GO:0006261)3.13449739
87regulation of centriole replication (GO:0046599)3.12448166
88sister chromatid segregation (GO:0000819)3.11271829
89synapsis (GO:0007129)3.10687097
90heterochromatin organization (GO:0070828)3.10128887
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07737828
92spindle checkpoint (GO:0031577)3.07566147
93mitotic recombination (GO:0006312)3.07549607
94regulation of centrosome cycle (GO:0046605)3.05652599
95attachment of spindle microtubules to kinetochore (GO:0008608)3.05319012
96ncRNA catabolic process (GO:0034661)3.03531501
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03152188
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02566997
99protein localization to chromosome (GO:0034502)3.01783841
100DNA ligation (GO:0006266)3.01733666
101telomere maintenance via recombination (GO:0000722)3.01456564
102kinetochore assembly (GO:0051382)3.01445032
103telomere maintenance via semi-conservative replication (GO:0032201)3.01008491
104somatic recombination of immunoglobulin gene segments (GO:0016447)3.00011094
105centriole assembly (GO:0098534)2.99266537
106microtubule anchoring (GO:0034453)2.98971787
107double-strand break repair via nonhomologous end joining (GO:0006303)2.98901911
108non-recombinational repair (GO:0000726)2.98901911
109DNA damage response, detection of DNA damage (GO:0042769)2.97916435
110monoubiquitinated protein deubiquitination (GO:0035520)2.97781218
111microtubule depolymerization (GO:0007019)2.97415955
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96771323
113histone H2A monoubiquitination (GO:0035518)2.96291916
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.95797881
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95797881
116rRNA catabolic process (GO:0016075)2.95567027
117ribosome biogenesis (GO:0042254)2.95324043
118regulation of chromatin silencing (GO:0031935)2.95108279
119negative regulation of chromosome segregation (GO:0051985)2.94723637
120recombinational repair (GO:0000725)2.94369513
121mitotic spindle checkpoint (GO:0071174)2.93381434
122spermatid nucleus differentiation (GO:0007289)2.92763922
123regulation of telomere maintenance via telomerase (GO:0032210)2.91908716
124negative regulation of neurological system process (GO:0031645)2.91314864
125double-strand break repair via homologous recombination (GO:0000724)2.90997763
126pre-miRNA processing (GO:0031054)2.90244826
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90160993
128negative regulation of sister chromatid segregation (GO:0033046)2.90160993
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.90160993
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90160993
131positive regulation of histone H3-K4 methylation (GO:0051571)2.88208647
132DNA conformation change (GO:0071103)2.88170372
133spindle assembly checkpoint (GO:0071173)2.87662487
134histone H2A acetylation (GO:0043968)2.87361576
135regulation of retinoic acid receptor signaling pathway (GO:0048385)2.86659135
136ATP-dependent chromatin remodeling (GO:0043044)2.86265342
137translesion synthesis (GO:0019985)2.85823994
138regulation of mitotic sister chromatid separation (GO:0010965)2.85633774
139regulation of mitotic sister chromatid segregation (GO:0033047)2.85633774
140regulation of sister chromatid segregation (GO:0033045)2.85633774
141nuclear envelope organization (GO:0006998)2.83225196
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83025592
143negative regulation of DNA repair (GO:0045738)2.83005465
144mitotic spindle assembly checkpoint (GO:0007094)2.82622520
145dosage compensation (GO:0007549)2.81207004
146mitotic G2/M transition checkpoint (GO:0044818)2.80307447
147IMP metabolic process (GO:0046040)2.79980858
148regulation of nucleobase-containing compound transport (GO:0032239)2.75187655
149telomere maintenance via telomere lengthening (GO:0010833)2.74619644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.61634607
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75343737
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02123485
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.82762134
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39652683
6ZNF274_21170338_ChIP-Seq_K562_Hela2.89134609
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73296770
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70852153
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.68529188
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.65280893
11AR_21909140_ChIP-Seq_LNCAP_Human2.62474168
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56722954
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53867724
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49446858
15FUS_26573619_Chip-Seq_HEK293_Human2.38265484
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36771854
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22231745
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22066564
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21919916
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.21299358
21EWS_26573619_Chip-Seq_HEK293_Human2.19312541
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17678025
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16529599
24* EST1_17652178_ChIP-ChIP_JURKAT_Human2.13223931
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12709760
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12672893
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.10929925
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07339692
29TAF15_26573619_Chip-Seq_HEK293_Human2.05779465
30IGF1R_20145208_ChIP-Seq_DFB_Human1.97839952
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97031827
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.95544318
33XRN2_22483619_ChIP-Seq_HELA_Human1.94971639
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93837985
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.93729327
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93362220
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91650510
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91650510
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91650510
40P300_19829295_ChIP-Seq_ESCs_Human1.85046335
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82846708
42VDR_23849224_ChIP-Seq_CD4+_Human1.82203662
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78130417
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.77640280
45VDR_22108803_ChIP-Seq_LS180_Human1.76403863
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70719348
47ELK1_19687146_ChIP-ChIP_HELA_Human1.70583841
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70213323
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69802427
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69421141
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66976225
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66765109
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65575975
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63475779
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60449734
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56975754
57GBX2_23144817_ChIP-Seq_PC3_Human1.56611973
58FOXP3_21729870_ChIP-Seq_TREG_Human1.55347225
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54454484
60TTF2_22483619_ChIP-Seq_HELA_Human1.53567612
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51718039
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45271885
63* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44129552
64DCP1A_22483619_ChIP-Seq_HELA_Human1.43323002
65* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42988904
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42549755
67CBP_20019798_ChIP-Seq_JUKART_Human1.40637713
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40637713
69KDM5A_27292631_Chip-Seq_BREAST_Human1.40089624
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.40046423
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39888221
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36948128
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34619631
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33586278
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33576721
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33015528
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32658069
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31454817
79* GABP_19822575_ChIP-Seq_HepG2_Human1.28576952
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27084696
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26535557
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25634804
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25414603
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24881320
85* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24400582
86CIITA_25753668_ChIP-Seq_RAJI_Human1.22920071
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21479142
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20556154
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20556154
90MYC_22102868_ChIP-Seq_BL_Human1.20498479
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20298488
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19766182
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19563708
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19468078
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19324868
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18342974
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17721045
98SMAD4_21799915_ChIP-Seq_A2780_Human1.16880759
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16712493
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16709825
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14867580
102* TFEB_21752829_ChIP-Seq_HELA_Human1.14415078
103IRF1_19129219_ChIP-ChIP_H3396_Human1.14249264
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14242469
105* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14155515
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.13757176
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13196971
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13181854
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11687948
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11654928
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10545084
112* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09809056
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.09802048
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09171942
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07254286
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06718789
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06569290
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06130947
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.04905233
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03569996
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03558091
122BCAT_22108803_ChIP-Seq_LS180_Human1.03196064
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.03016139
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.02752727
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02621615
126STAT3_23295773_ChIP-Seq_U87_Human1.02438350
127* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01819787
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01658847
129THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01097874
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00470794
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.99636124
132* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99073606
133ER_23166858_ChIP-Seq_MCF-7_Human0.98939623
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97759809
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97353317
136TP53_22573176_ChIP-Seq_HFKS_Human0.96086372
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.95903072
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95314624
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94657146
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94461870
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94262221
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94092348
143SALL4_22934838_ChIP-ChIP_CD34+_Human0.93144506
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92630141
145CRX_20693478_ChIP-Seq_RETINA_Mouse0.92576586
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92291312
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92056676
148SOX2_19829295_ChIP-Seq_ESCs_Human0.91877691
149NANOG_19829295_ChIP-Seq_ESCs_Human0.91877691
150TCF4_23295773_ChIP-Seq_U87_Human0.90239792
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.90173452
152* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89868723
153SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89011528
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88382110
155* ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88248984
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87721229
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86050845
158CHD1_26751641_Chip-Seq_LNCaP_Human0.85955900
159MYC_18940864_ChIP-ChIP_HL60_Human0.85804039
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84311277
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82213109
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.81390731
163YY1_21170310_ChIP-Seq_MESCs_Mouse0.80434832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.01097049
2MP0003693_abnormal_embryo_hatching3.82150470
3MP0008057_abnormal_DNA_replication3.80130585
4MP0003111_abnormal_nucleus_morphology3.56552628
5MP0004957_abnormal_blastocyst_morpholog3.42360237
6MP0003077_abnormal_cell_cycle3.40333216
7MP0008877_abnormal_DNA_methylation3.01176127
8MP0008007_abnormal_cellular_replicative2.76749168
9MP0008058_abnormal_DNA_repair2.74145615
10MP0008789_abnormal_olfactory_epithelium2.48361483
11MP0001730_embryonic_growth_arrest2.32952559
12MP0010352_gastrointestinal_tract_polyps2.30056010
13MP0010307_abnormal_tumor_latency2.27071367
14MP0000350_abnormal_cell_proliferation2.16919298
15MP0003123_paternal_imprinting2.08679244
16MP0000569_abnormal_digit_pigmentation2.06180892
17MP0008932_abnormal_embryonic_tissue2.03765054
18MP0009697_abnormal_copulation1.96799251
19MP0005394_taste/olfaction_phenotype1.96421237
20MP0005499_abnormal_olfactory_system1.96421237
21MP0005380_embryogenesis_phenotype1.78768861
22MP0001672_abnormal_embryogenesis/_devel1.78768861
23MP0001697_abnormal_embryo_size1.77907948
24MP0005076_abnormal_cell_differentiation1.77553086
25MP0002084_abnormal_developmental_patter1.75700481
26MP0003786_premature_aging1.74111451
27MP0001529_abnormal_vocalization1.69191560
28MP0002085_abnormal_embryonic_tissue1.68876901
29MP0004197_abnormal_fetal_growth/weight/1.68808721
30MP0001293_anophthalmia1.66693187
31MP0002396_abnormal_hematopoietic_system1.62968054
32MP0003984_embryonic_growth_retardation1.59881728
33MP0002086_abnormal_extraembryonic_tissu1.58204312
34MP0003941_abnormal_skin_development1.57907963
35MP0002088_abnormal_embryonic_growth/wei1.57566178
36MP0006072_abnormal_retinal_apoptosis1.53838697
37MP0005075_abnormal_melanosome_morpholog1.53302679
38MP0003121_genomic_imprinting1.52910757
39MP0010030_abnormal_orbit_morphology1.50961156
40MP0003937_abnormal_limbs/digits/tail_de1.49389875
41MP0005410_abnormal_fertilization1.48530141
42MP0003705_abnormal_hypodermis_morpholog1.44473114
43MP0002080_prenatal_lethality1.44435013
44MP0003890_abnormal_embryonic-extraembry1.40540849
45MP0005395_other_phenotype1.36526216
46MP0002210_abnormal_sex_determination1.35401591
47MP0004808_abnormal_hematopoietic_stem1.34165994
48MP0009053_abnormal_anal_canal1.29239760
49MP0003122_maternal_imprinting1.27328123
50MP0003718_maternal_effect1.26962631
51MP0002653_abnormal_ependyma_morphology1.24663502
52MP0002102_abnormal_ear_morphology1.21839895
53MP0001145_abnormal_male_reproductive1.20965679
54MP0003567_abnormal_fetal_cardiomyocyte1.20718282
55MP0000427_abnormal_hair_cycle1.20606682
56MP0006035_abnormal_mitochondrial_morpho1.19326501
57MP0001929_abnormal_gametogenesis1.19003243
58MP0003283_abnormal_digestive_organ1.17446906
59MP0000647_abnormal_sebaceous_gland1.17214599
60MP0000313_abnormal_cell_death1.15181138
61MP0000537_abnormal_urethra_morphology1.14624963
62MP0000490_abnormal_crypts_of1.13818136
63MP0002019_abnormal_tumor_incidence1.10423087
64MP0002254_reproductive_system_inflammat1.09947048
65MP0000653_abnormal_sex_gland1.08551816
66MP0002697_abnormal_eye_size1.05642861
67MP0004133_heterotaxia1.05158577
68MP0002111_abnormal_tail_morphology1.04821278
69MP0002092_abnormal_eye_morphology1.04217492
70MP0001188_hyperpigmentation1.02098522
71MP0001286_abnormal_eye_development1.01381922
72MP0005023_abnormal_wound_healing1.00213215
73MP0003806_abnormal_nucleotide_metabolis0.99014018
74MP0002009_preneoplasia0.97292144
75MP0003195_calcinosis0.96660023
76MP0002234_abnormal_pharynx_morphology0.96473242
77MP0000432_abnormal_head_morphology0.95384309
78MP0005253_abnormal_eye_physiology0.94995744
79MP0000428_abnormal_craniofacial_morphol0.93026063
80MP0002090_abnormal_vision0.91546045
81MP0006292_abnormal_olfactory_placode0.90720339
82MP0008438_abnormal_cutaneous_collagen0.90456658
83MP0003699_abnormal_female_reproductive0.90325029
84MP0002138_abnormal_hepatobiliary_system0.90281112
85MP0003119_abnormal_digestive_system0.90032896
86MP0002161_abnormal_fertility/fecundity0.89574498
87MP0009703_decreased_birth_body0.89110579
88MP0005084_abnormal_gallbladder_morpholo0.87855859
89MP0009672_abnormal_birth_weight0.87653746
90MP0002277_abnormal_respiratory_mucosa0.87432492
91MP0003315_abnormal_perineum_morphology0.86825485
92MP0003787_abnormal_imprinting0.84447308
93MP0001984_abnormal_olfaction0.83676611
94MP0001915_intracranial_hemorrhage0.82434624
95MP0005551_abnormal_eye_electrophysiolog0.80748918
96MP0003935_abnormal_craniofacial_develop0.80528561
97MP0000358_abnormal_cell_content/0.80196129
98MP0001119_abnormal_female_reproductive0.80007705
99MP0009278_abnormal_bone_marrow0.79813754
100MP0002751_abnormal_autonomic_nervous0.79503682
101MP0001324_abnormal_eye_pigmentation0.79487100
102MP0004142_abnormal_muscle_tone0.79123282
103MP0005187_abnormal_penis_morphology0.77933685
104MP0000631_abnormal_neuroendocrine_gland0.77226068
105MP0000733_abnormal_muscle_development0.77024948
106MP0003755_abnormal_palate_morphology0.75848690
107MP0005174_abnormal_tail_pigmentation0.75559199
108MP0002282_abnormal_trachea_morphology0.74897027
109MP0005397_hematopoietic_system_phenotyp0.73735803
110MP0001545_abnormal_hematopoietic_system0.73735803
111MP0000516_abnormal_urinary_system0.73727846
112MP0005367_renal/urinary_system_phenotyp0.73727846
113MP0002877_abnormal_melanocyte_morpholog0.72949457
114MP0003566_abnormal_cell_adhesion0.72303800
115MP0003115_abnormal_respiratory_system0.72284932
116MP0002925_abnormal_cardiovascular_devel0.71969675
117MP0005389_reproductive_system_phenotype0.71457483
118MP0005248_abnormal_Harderian_gland0.71199046
119MP0005391_vision/eye_phenotype0.71043624
120MP0000015_abnormal_ear_pigmentation0.70980694
121MP0001919_abnormal_reproductive_system0.70275197
122MP0002938_white_spotting0.69894737
123MP0002249_abnormal_larynx_morphology0.69548342
124MP0002095_abnormal_skin_pigmentation0.68817611
125MP0003186_abnormal_redox_activity0.68571847
126MP0003943_abnormal_hepatobiliary_system0.68508854
127MP0002932_abnormal_joint_morphology0.68285890
128MP0001177_atelectasis0.67679413
129MP0001873_stomach_inflammation0.67023073
130MP0009333_abnormal_splenocyte_physiolog0.66156138
131MP0000703_abnormal_thymus_morphology0.65944772
132MP0005408_hypopigmentation0.65002788
133MP0003942_abnormal_urinary_system0.64918897
134MP0005621_abnormal_cell_physiology0.63783398
135MP0005508_abnormal_skeleton_morphology0.62796925
136MP0005384_cellular_phenotype0.62117161
137MP0000477_abnormal_intestine_morphology0.62058850
138MP0003763_abnormal_thymus_physiology0.61877088
139MP0003698_abnormal_male_reproductive0.60526024
140MP0002160_abnormal_reproductive_system0.59221309
141MP0005257_abnormal_intraocular_pressure0.57316457
142MP0002233_abnormal_nose_morphology0.57121984
143MP0008995_early_reproductive_senescence0.57041283
144MP0003936_abnormal_reproductive_system0.56689326

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.96089186
2Chromsome breakage (HP:0040012)3.77298420
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44636691
4Breast hypoplasia (HP:0003187)3.30373716
5Ependymoma (HP:0002888)3.19395993
6Medulloblastoma (HP:0002885)3.18399581
7Abnormality of chromosome stability (HP:0003220)3.12205682
8Impulsivity (HP:0100710)3.08118545
9Supernumerary spleens (HP:0009799)3.04315981
10Colon cancer (HP:0003003)2.93905793
11Amyotrophic lateral sclerosis (HP:0007354)2.91126969
12Patellar aplasia (HP:0006443)2.90721895
13Selective tooth agenesis (HP:0001592)2.90589527
14Proximal placement of thumb (HP:0009623)2.86491642
1511 pairs of ribs (HP:0000878)2.84146581
16Deviation of the thumb (HP:0009603)2.83908185
17Rhabdomyosarcoma (HP:0002859)2.78270563
18Meckel diverticulum (HP:0002245)2.78089599
19Missing ribs (HP:0000921)2.77044272
20Abnormality of the anterior horn cell (HP:0006802)2.76380134
21Degeneration of anterior horn cells (HP:0002398)2.76380134
22Facial hemangioma (HP:0000329)2.71538202
23Aplasia/Hypoplasia of the patella (HP:0006498)2.70103042
24Neoplasm of the oral cavity (HP:0100649)2.68329932
25Pancreatic cysts (HP:0001737)2.66219232
26Abnormality of the labia minora (HP:0012880)2.65343601
27Agnosia (HP:0010524)2.61183444
28Volvulus (HP:0002580)2.60477775
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.59778076
30Abnormality of the ileum (HP:0001549)2.59673543
31Absent radius (HP:0003974)2.54383178
32Broad alveolar ridges (HP:0000187)2.53911839
33Aplasia/hypoplasia of the humerus (HP:0006507)2.51394636
34Chronic hepatic failure (HP:0100626)2.48310978
35Biliary tract neoplasm (HP:0100574)2.47757068
36Pancreatic fibrosis (HP:0100732)2.46422336
37Molar tooth sign on MRI (HP:0002419)2.45160803
38Abnormality of midbrain morphology (HP:0002418)2.45160803
39Intestinal atresia (HP:0011100)2.43099585
40Pancreatic islet-cell hyperplasia (HP:0004510)2.41410099
41Abnormality of the preputium (HP:0100587)2.36528320
42Carpal bone hypoplasia (HP:0001498)2.35006383
43Aplasia involving forearm bones (HP:0009822)2.33659575
44Absent forearm bone (HP:0003953)2.33659575
45Short humerus (HP:0005792)2.31190785
46Medial flaring of the eyebrow (HP:0010747)2.26315828
47Papillary thyroid carcinoma (HP:0002895)2.25687751
48Myelodysplasia (HP:0002863)2.23052895
49Atresia of the external auditory canal (HP:0000413)2.19849284
50Abnormality of the astrocytes (HP:0100707)2.19402267
51Astrocytoma (HP:0009592)2.19402267
52Reticulocytopenia (HP:0001896)2.19166865
53Methylmalonic acidemia (HP:0002912)2.18947817
54Neoplasm of the pancreas (HP:0002894)2.18684901
55Sloping forehead (HP:0000340)2.18122531
56Oligodactyly (hands) (HP:0001180)2.16500052
57Sandal gap (HP:0001852)2.15552638
58Short thumb (HP:0009778)2.15433377
59Abnormality of DNA repair (HP:0003254)2.13910294
60Abnormal hair whorl (HP:0010721)2.13470493
61Duodenal stenosis (HP:0100867)2.13384574
62Small intestinal stenosis (HP:0012848)2.13384574
63Basal cell carcinoma (HP:0002671)2.11223280
64Glioma (HP:0009733)2.10854389
65Abdominal situs inversus (HP:0003363)2.10096934
66Abnormality of abdominal situs (HP:0011620)2.10096934
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.09971595
68Neoplasm of striated muscle (HP:0009728)2.09383346
69Rib fusion (HP:0000902)2.07916978
70Gonadotropin excess (HP:0000837)2.07521912
71Optic nerve hypoplasia (HP:0000609)2.06907211
72Fair hair (HP:0002286)2.06272210
73Tubulointerstitial nephritis (HP:0001970)2.04586707
74Long eyelashes (HP:0000527)2.04334194
75Ectopic kidney (HP:0000086)2.03252116
76Stomach cancer (HP:0012126)2.02360269
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.00670815
78Shawl scrotum (HP:0000049)2.00563195
79Nephronophthisis (HP:0000090)2.00545509
80Short 4th metacarpal (HP:0010044)1.95854487
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95854487
82Abnormality of the duodenum (HP:0002246)1.95040571
83Abnormal spermatogenesis (HP:0008669)1.94773938
84Malignant gastrointestinal tract tumors (HP:0006749)1.94406783
85Gastrointestinal carcinoma (HP:0002672)1.94406783
86Stenosis of the external auditory canal (HP:0000402)1.93815701
87Median cleft lip (HP:0000161)1.93477873
88Clubbing of toes (HP:0100760)1.91559112
89Septo-optic dysplasia (HP:0100842)1.89246251
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89132002
91True hermaphroditism (HP:0010459)1.88773831
92Thyroid carcinoma (HP:0002890)1.87312129
93Oral leukoplakia (HP:0002745)1.84625458
94Increased nuchal translucency (HP:0010880)1.84031582
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.83158077
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.83122642
97Anencephaly (HP:0002323)1.82411344
98Abnormality of the renal medulla (HP:0100957)1.82308406
99Abnormal biliary tract morphology (HP:0012440)1.81945161
100Absent thumb (HP:0009777)1.81920859
101Hypoplasia of the radius (HP:0002984)1.81570175
102Small hand (HP:0200055)1.81145682
103Rectovaginal fistula (HP:0000143)1.79995720
104Rectal fistula (HP:0100590)1.79995720
105Capillary hemangiomas (HP:0005306)1.79717713
106Amaurosis fugax (HP:0100576)1.79441528
107Squamous cell carcinoma (HP:0002860)1.79425325
108Abnormality of the carotid arteries (HP:0005344)1.79331586
109Prominent nose (HP:0000448)1.79233334
110Hyperglycinemia (HP:0002154)1.79145781
111Nephroblastoma (Wilms tumor) (HP:0002667)1.78303232
112Abnormal lung lobation (HP:0002101)1.77612040
113Skull defect (HP:0001362)1.77446144
114Horseshoe kidney (HP:0000085)1.77432653
115Cafe-au-lait spot (HP:0000957)1.76972725
116Supernumerary bones of the axial skeleton (HP:0009144)1.76744459
117Broad palm (HP:0001169)1.76024584
118Abnormality of the septum pellucidum (HP:0007375)1.76022758
119Embryonal renal neoplasm (HP:0011794)1.75250048
120Abnormality of the metopic suture (HP:0005556)1.75147208
121Acute myeloid leukemia (HP:0004808)1.75113868
122Poikiloderma (HP:0001029)1.74363937
123Supernumerary ribs (HP:0005815)1.74171669
124Sclerocornea (HP:0000647)1.73393797
125Ankle contracture (HP:0006466)1.73170016
126Hyperinsulinemic hypoglycemia (HP:0000825)1.73121810
127Aqueductal stenosis (HP:0002410)1.72625281
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.72598114
129High pitched voice (HP:0001620)1.72205999
130Pelvic girdle muscle weakness (HP:0003749)1.70977813
131Arteriovenous malformation (HP:0100026)1.70739247
132Rough bone trabeculation (HP:0100670)1.69575856
133Abnormality of the 1st metacarpal (HP:0010009)1.68971118
134Neoplasm of the adrenal cortex (HP:0100641)1.68454159
135Congenital primary aphakia (HP:0007707)1.68360106
136Neoplasm of the colon (HP:0100273)1.67568871
137Adactyly (HP:0009776)1.67060651
138Abnormality of cells of the erythroid lineage (HP:0012130)1.66290108
139Progressive inability to walk (HP:0002505)1.66059903
140Short ribs (HP:0000773)1.65706899
141Tracheoesophageal fistula (HP:0002575)1.65236662
142Triphalangeal thumb (HP:0001199)1.65183135
143Hypoplastic labia majora (HP:0000059)1.65119451
144Oligodactyly (HP:0012165)1.64875193
145Acute necrotizing encephalopathy (HP:0006965)1.64694263
146Broad thumb (HP:0011304)1.64613746
147Cutaneous melanoma (HP:0012056)1.64553587
148Dandy-Walker malformation (HP:0001305)1.63542436
149Hypoplastic female external genitalia (HP:0012815)1.62778488
150Astigmatism (HP:0000483)1.62701829
151Abnormality of the pons (HP:0007361)1.62622385
152Azoospermia (HP:0000027)1.62427521
153Abnormality of the hip-girdle musculature (HP:0001445)1.62269666
154Abnormality of the musculature of the pelvis (HP:0001469)1.62269666
155Nephrogenic diabetes insipidus (HP:0009806)1.62200392
156Aplasia/Hypoplasia of the hallux (HP:0008362)1.61998284
157Progressive macrocephaly (HP:0004481)1.61306097
158Hypochromic microcytic anemia (HP:0004840)1.61042111
159Genital tract atresia (HP:0001827)1.60433957
160Cerebellar dysplasia (HP:0007033)1.59218269
161Gastrointestinal atresia (HP:0002589)1.58811694
162Micropenis (HP:0000054)1.58617613
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.58592092
164Gait imbalance (HP:0002141)1.57236178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.36742338
2WEE13.84097300
3CDK123.29947029
4NEK23.02772847
5BMPR1B3.02354666
6TRIM282.78717368
7SRPK12.75862009
8BUB12.62222524
9ACVR1B2.44232771
10TTK2.24074868
11PLK42.14487661
12BRSK22.11097008
13WNK32.07741083
14MKNK12.06162168
15TNIK2.01851734
16EPHA22.01201022
17* PLK11.98870261
18CDK71.89737147
19MKNK21.82375518
20DYRK31.79428528
21LATS11.78086143
22TLK11.76442845
23PASK1.76051095
24PLK31.74295511
25CHEK21.71224043
26AURKB1.70364063
27ATR1.61949776
28RPS6KB21.58627651
29MAP4K21.58006835
30INSRR1.57710188
31TSSK61.57601464
32STK101.51507868
33EIF2AK11.50515351
34BRD41.49315758
35VRK11.48462532
36CHEK11.40308591
37PNCK1.39876885
38TGFBR11.38799868
39RPS6KA41.37477552
40PLK21.35417577
41STK38L1.33487928
42MAP3K101.29598822
43STK41.29020786
44BCR1.28910679
45CDK41.28606651
46STK31.27072144
47MELK1.26130255
48ZAK1.20866460
49CASK1.20567797
50MAP3K81.19975703
51MAP3K41.17078963
52ATM1.16798999
53EIF2AK31.14508536
54CDK61.08072949
55AURKA1.00620853
56PBK0.99615723
57PIM10.96896914
58CSNK1G20.95243169
59* CDK20.94863367
60CSNK1G10.94276179
61CCNB10.91559113
62NME20.90094334
63NEK90.89483479
64NEK10.88556058
65GRK10.87263985
66TAF10.85861759
67RAF10.82682052
68MET0.82285165
69BRAF0.80984128
70* MTOR0.78980160
71LATS20.77582933
72PDK40.76569953
73PDK30.76569953
74CDK10.75151970
75TEC0.74372208
76TESK20.74093922
77MAPK130.73685562
78PDK20.71425891
79FLT30.71358912
80RPS6KA50.69407254
81CDK90.68412642
82ALK0.63506440
83PAK40.62414094
84PAK20.62221471
85FRK0.61239943
86EEF2K0.60965399
87CSNK2A20.59760744
88BRSK10.58369218
89PKN20.57902116
90CSNK1G30.55664541
91CHUK0.55540314
92ERBB30.55140902
93MAP2K70.54993541
94EIF2AK20.53892448
95CSNK1A1L0.53755404
96RIPK10.52521726
97PRKCI0.52306588
98NUAK10.51125892
99DMPK0.50804378
100STK240.49468509
101YES10.48860369
102OXSR10.48101584
103CSNK2A10.47910438
104IRAK10.46997780
105SCYL20.46403768
106CSNK1D0.46111703
107MAPK150.45883057
108CSNK1E0.45311523
109TESK10.45235289
110STK160.44427488
111ERBB40.43965188
112DYRK20.43538746
113CAMK1G0.42983405
114CDK80.42497348
115TAOK30.42001694
116CLK10.41267644
117NEK60.40276093
118MAPK140.39331321
119MARK30.38697094
120IRAK20.38604119
121PRKDC0.38326163
122PAK10.37598681
123MAPK10.37353961
124LRRK20.36171337
125DYRK1A0.34961648
126TXK0.34485813
127JAK30.34164106
128MST1R0.33993994
129KSR10.32577241
130CDK30.32219419
131NLK0.31933793
132ADRBK20.31251529
133WNK10.31241817
134STK110.31092383
135AKT30.30377897
136FGFR10.30158794
137PDGFRA0.28104287
138AKT10.28084534
139MST40.27031691

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.05239742
2Mismatch repair_Homo sapiens_hsa034303.93570504
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69046613
4RNA transport_Homo sapiens_hsa030133.22087449
5Spliceosome_Homo sapiens_hsa030403.14203291
6Cell cycle_Homo sapiens_hsa041103.04377602
7Homologous recombination_Homo sapiens_hsa034402.98261103
8RNA polymerase_Homo sapiens_hsa030202.95247133
9Fanconi anemia pathway_Homo sapiens_hsa034602.68400663
10One carbon pool by folate_Homo sapiens_hsa006702.66256476
11Nucleotide excision repair_Homo sapiens_hsa034202.64063315
12Basal transcription factors_Homo sapiens_hsa030222.31863498
13Base excision repair_Homo sapiens_hsa034102.30124443
14Non-homologous end-joining_Homo sapiens_hsa034502.27345182
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20080221
16Regulation of autophagy_Homo sapiens_hsa041402.12235718
17mRNA surveillance pathway_Homo sapiens_hsa030152.05165323
18Ribosome_Homo sapiens_hsa030101.96251210
19RNA degradation_Homo sapiens_hsa030181.95876482
20Systemic lupus erythematosus_Homo sapiens_hsa053221.86951310
21Pyrimidine metabolism_Homo sapiens_hsa002401.86453075
22p53 signaling pathway_Homo sapiens_hsa041151.83553091
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72398002
24Proteasome_Homo sapiens_hsa030501.60824759
25Viral carcinogenesis_Homo sapiens_hsa052031.32725431
26Propanoate metabolism_Homo sapiens_hsa006401.28223849
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24759905
28MicroRNAs in cancer_Homo sapiens_hsa052061.23681036
29Selenocompound metabolism_Homo sapiens_hsa004501.23606948
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17176939
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12175074
32TGF-beta signaling pathway_Homo sapiens_hsa043501.11256680
33Antigen processing and presentation_Homo sapiens_hsa046121.08231807
34Herpes simplex infection_Homo sapiens_hsa051681.05548482
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01886618
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99992335
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99746717
38Small cell lung cancer_Homo sapiens_hsa052220.97859158
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97156684
40Oocyte meiosis_Homo sapiens_hsa041140.95335439
41Thyroid cancer_Homo sapiens_hsa052160.95043050
42Purine metabolism_Homo sapiens_hsa002300.94620841
43Steroid biosynthesis_Homo sapiens_hsa001000.92693503
44Circadian rhythm_Homo sapiens_hsa047100.91062501
45Vitamin B6 metabolism_Homo sapiens_hsa007500.90577318
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88891084
47HTLV-I infection_Homo sapiens_hsa051660.87670422
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.84715115
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84692222
50Pentose phosphate pathway_Homo sapiens_hsa000300.83550638
51Folate biosynthesis_Homo sapiens_hsa007900.81346021
52Adherens junction_Homo sapiens_hsa045200.81345491
53Hippo signaling pathway_Homo sapiens_hsa043900.78003327
54Sulfur relay system_Homo sapiens_hsa041220.76300015
55Basal cell carcinoma_Homo sapiens_hsa052170.75203942
56Butanoate metabolism_Homo sapiens_hsa006500.73002099
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.70365462
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68568112
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68258601
60Alcoholism_Homo sapiens_hsa050340.67949510
61Chronic myeloid leukemia_Homo sapiens_hsa052200.65572221
62Prostate cancer_Homo sapiens_hsa052150.65513361
63Type I diabetes mellitus_Homo sapiens_hsa049400.64993680
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.64257283
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64169341
66Taste transduction_Homo sapiens_hsa047420.62695622
67Biosynthesis of amino acids_Homo sapiens_hsa012300.62601833
68Nitrogen metabolism_Homo sapiens_hsa009100.61444744
69Phototransduction_Homo sapiens_hsa047440.61347882
70Colorectal cancer_Homo sapiens_hsa052100.59576752
71Notch signaling pathway_Homo sapiens_hsa043300.59529995
72Hedgehog signaling pathway_Homo sapiens_hsa043400.58718152
73Lysine degradation_Homo sapiens_hsa003100.58138477
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57456373
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55685033
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.54570256
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53610484
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52960870
79Glutathione metabolism_Homo sapiens_hsa004800.52607709
80Parkinsons disease_Homo sapiens_hsa050120.51686572
81Nicotine addiction_Homo sapiens_hsa050330.51555299
82Apoptosis_Homo sapiens_hsa042100.51497513
83Bladder cancer_Homo sapiens_hsa052190.51151709
84Huntingtons disease_Homo sapiens_hsa050160.50972815
85Olfactory transduction_Homo sapiens_hsa047400.50826711
86Dorso-ventral axis formation_Homo sapiens_hsa043200.49672049
87Peroxisome_Homo sapiens_hsa041460.48829004
88Fatty acid elongation_Homo sapiens_hsa000620.48030666
89Pathways in cancer_Homo sapiens_hsa052000.47484003
90Hepatitis B_Homo sapiens_hsa051610.44959515
91Allograft rejection_Homo sapiens_hsa053300.44831710
92Oxidative phosphorylation_Homo sapiens_hsa001900.42684809
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42384879
94Legionellosis_Homo sapiens_hsa051340.41029774
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39573899
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.37491435
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35668083
98Measles_Homo sapiens_hsa051620.35491467
99Proteoglycans in cancer_Homo sapiens_hsa052050.35308770
100Wnt signaling pathway_Homo sapiens_hsa043100.35032862
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33870897
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33854809
103Rheumatoid arthritis_Homo sapiens_hsa053230.33401709
104mTOR signaling pathway_Homo sapiens_hsa041500.32758971
105Pancreatic cancer_Homo sapiens_hsa052120.32509687
106Graft-versus-host disease_Homo sapiens_hsa053320.31781606
107Fatty acid biosynthesis_Homo sapiens_hsa000610.31645363
108Tight junction_Homo sapiens_hsa045300.31285855
109Protein export_Homo sapiens_hsa030600.30709696
110ECM-receptor interaction_Homo sapiens_hsa045120.30589139
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29854227
112Caffeine metabolism_Homo sapiens_hsa002320.28594645
113FoxO signaling pathway_Homo sapiens_hsa040680.27159502
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26860211
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25294304
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.24597583
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.24294305
118Fatty acid metabolism_Homo sapiens_hsa012120.22765068
119Melanoma_Homo sapiens_hsa052180.22473082
120Influenza A_Homo sapiens_hsa051640.22233802
121Endometrial cancer_Homo sapiens_hsa052130.22174960
122Non-small cell lung cancer_Homo sapiens_hsa052230.21929276
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21662558
124Metabolic pathways_Homo sapiens_hsa011000.21592131
125Acute myeloid leukemia_Homo sapiens_hsa052210.20850495
126Asthma_Homo sapiens_hsa053100.20730491
127Arachidonic acid metabolism_Homo sapiens_hsa005900.20601291
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19897416
129Renal cell carcinoma_Homo sapiens_hsa052110.19699244
130Focal adhesion_Homo sapiens_hsa045100.19364996
131Tryptophan metabolism_Homo sapiens_hsa003800.18776861
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18042564
133Viral myocarditis_Homo sapiens_hsa054160.16865028
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.15779622
135Linoleic acid metabolism_Homo sapiens_hsa005910.15722820
136HIF-1 signaling pathway_Homo sapiens_hsa040660.14869300
137Shigellosis_Homo sapiens_hsa051310.14825166
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14272178
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.14243120
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14202165
141Pyruvate metabolism_Homo sapiens_hsa006200.12319610
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11896400

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