TOR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an ATPase found primarily in the endoplasmic reticulum and nuclear envelope. This gene has a highly-similar neighboring gene, TOR1A, that encodes a protein that is likely to interact in a complex with this protein. Finally, this protein may act as a chaperone and play a role in maintaining the integrity of the nuclear envelope and endoplasmic reticulum. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.49999852
2COPI coating of Golgi vesicle (GO:0048205)5.49999852
3epithelial cell fate commitment (GO:0072148)4.84950061
4exocrine pancreas development (GO:0031017)4.62466396
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.55956250
6positive regulation by symbiont of host defense response (GO:0052509)4.32933177
7modulation by symbiont of host defense response (GO:0052031)4.32933177
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32933177
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32933177
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.32933177
11modulation by symbiont of host immune response (GO:0052553)4.32933177
12protein localization to endosome (GO:0036010)4.20677282
13response to peptidoglycan (GO:0032494)4.14125476
14type B pancreatic cell development (GO:0003323)4.13753975
15UDP-N-acetylglucosamine metabolic process (GO:0006047)4.03952487
16lung epithelium development (GO:0060428)4.02522079
17chondrocyte proliferation (GO:0035988)3.96951301
18negative regulation of interleukin-12 production (GO:0032695)3.89718945
19cellular response to type I interferon (GO:0071357)3.86276174
20type I interferon signaling pathway (GO:0060337)3.86276174
21protein retention in ER lumen (GO:0006621)3.84550655
22detection of molecule of bacterial origin (GO:0032490)3.82742980
23response to type I interferon (GO:0034340)3.80500624
24macrophage activation involved in immune response (GO:0002281)3.72671448
25activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.66779332
26signal peptide processing (GO:0006465)3.65810468
27positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.61932471
28negative regulation of cell killing (GO:0031342)3.57528933
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57528933
30positive regulation of nuclease activity (GO:0032075)3.56672963
31COPII vesicle coating (GO:0048208)3.53481542
32negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.51997196
33regulation of interferon-beta biosynthetic process (GO:0045357)3.51840259
34epithelial cell differentiation involved in prostate gland development (GO:0060742)3.50986960
35glandular epithelial cell differentiation (GO:0002067)3.50716879
36endocardial cushion morphogenesis (GO:0003203)3.45747086
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.45069632
38folic acid-containing compound biosynthetic process (GO:0009396)3.41537043
39antigen processing and presentation of endogenous antigen (GO:0019883)3.39300628
40detection of other organism (GO:0098543)3.36540745
41positive regulation of keratinocyte differentiation (GO:0045618)3.32701419
42Notch signaling involved in heart development (GO:0061314)3.30885408
43regulation of endothelial cell chemotaxis (GO:2001026)3.30809903
44regulation of nuclease activity (GO:0032069)3.30637134
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.29449963
46L-phenylalanine catabolic process (GO:0006559)3.29449963
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26018451
48endoplasmic reticulum unfolded protein response (GO:0030968)3.22470588
49detection of external biotic stimulus (GO:0098581)3.22374234
50epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.21340304
51valine metabolic process (GO:0006573)3.21106519
52regulation of vitamin D biosynthetic process (GO:0060556)3.20030909
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.19071186
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18378880
55regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.15042704
56regulation of type I interferon-mediated signaling pathway (GO:0060338)3.14894033
57glandular epithelial cell development (GO:0002068)3.13627994
58cellular response to interferon-alpha (GO:0035457)3.13420750
59L-phenylalanine metabolic process (GO:0006558)3.11242472
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11242472
61cellular response to unfolded protein (GO:0034620)3.11137820
62IMP biosynthetic process (GO:0006188)3.05541554
63detection of bacterium (GO:0016045)3.02268278
64response to interferon-alpha (GO:0035455)3.00389612
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97563686
66neutrophil activation involved in immune response (GO:0002283)2.96469524
67positive regulation of gamma-delta T cell activation (GO:0046645)2.95793532
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95072933
69NIK/NF-kappaB signaling (GO:0038061)2.94756011
70folic acid metabolic process (GO:0046655)2.94409035
71ER-nucleus signaling pathway (GO:0006984)2.93915674
72cellular response to topologically incorrect protein (GO:0035967)2.92828379
73venous blood vessel morphogenesis (GO:0048845)2.92374445
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.91957116
75regulation of T-helper 2 cell differentiation (GO:0045628)2.91698951
76response to host immune response (GO:0052572)2.91220841
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91220841
78leukocyte aggregation (GO:0070486)2.91151902
79myoblast migration (GO:0051451)2.90579658
80positive regulation of type 2 immune response (GO:0002830)2.90226307
81cell adhesion mediated by integrin (GO:0033627)2.90018237
82retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89366616
83atrioventricular valve morphogenesis (GO:0003181)2.89174766
84regulation of interferon-alpha production (GO:0032647)2.88863649
85regulation of extracellular matrix organization (GO:1903053)2.88420401
86response to host (GO:0075136)2.88174859
87response to host defenses (GO:0052200)2.88174859
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88174859
89midgut development (GO:0007494)2.87693067
90response to laminar fluid shear stress (GO:0034616)2.87473372
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86258860
92positive regulation of interferon-alpha production (GO:0032727)2.81731438
93regulation of vitamin metabolic process (GO:0030656)2.81057794
94regulation of retinoic acid receptor signaling pathway (GO:0048385)2.80321833
95regulation of necroptotic process (GO:0060544)2.76958501
96glycine metabolic process (GO:0006544)2.76729030
97detection of biotic stimulus (GO:0009595)2.73739200
98coronary vasculature morphogenesis (GO:0060977)2.73676581
99tryptophan metabolic process (GO:0006568)2.72489078
100aromatic amino acid family catabolic process (GO:0009074)2.72428184
101regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72351101
102immunoglobulin mediated immune response (GO:0016064)2.71985832
103purine nucleobase biosynthetic process (GO:0009113)2.71704727
104regulation of type 2 immune response (GO:0002828)2.70995553
105lens fiber cell development (GO:0070307)2.70517860
106vitamin transmembrane transport (GO:0035461)2.68262035
107production of molecular mediator involved in inflammatory response (GO:0002532)2.68162474
108germinal center formation (GO:0002467)2.65141766
109skin morphogenesis (GO:0043589)2.62729852
110myeloid dendritic cell differentiation (GO:0043011)2.62361783
111protein maturation by protein folding (GO:0022417)2.62357761
112nucleotide-sugar biosynthetic process (GO:0009226)2.62034899
113negative regulation of cytokine production involved in immune response (GO:0002719)2.61628993
114cellular extravasation (GO:0045123)2.61119810
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58370821
116stress fiber assembly (GO:0043149)2.57490404
117regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57070417
118regulation of leukocyte degranulation (GO:0043300)2.56419158
119protein carboxylation (GO:0018214)2.54018689
120peptidyl-glutamic acid carboxylation (GO:0017187)2.54018689
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53625681
122cell migration involved in heart development (GO:0060973)2.52813749
123tryptophan catabolic process (GO:0006569)2.52725879
124indole-containing compound catabolic process (GO:0042436)2.52725879
125indolalkylamine catabolic process (GO:0046218)2.52725879
126alpha-linolenic acid metabolic process (GO:0036109)2.52486670
127nucleobase biosynthetic process (GO:0046112)2.51749528
128peptide catabolic process (GO:0043171)2.51685007
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51603282
130regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.48351405
131mannose metabolic process (GO:0006013)2.48311155
132negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46253600
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45892071
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45892071
135regulation of T-helper 1 cell differentiation (GO:0045625)2.45577300
136amyloid precursor protein catabolic process (GO:0042987)2.45254781
137pteridine-containing compound biosynthetic process (GO:0042559)2.44642878
138cellular zinc ion homeostasis (GO:0006882)2.44565187
139interferon-gamma-mediated signaling pathway (GO:0060333)2.44419652
140inner ear receptor cell differentiation (GO:0060113)2.43361411
141macrophage activation (GO:0042116)2.42636614
142granulocyte activation (GO:0036230)2.41702253
143cellular response to virus (GO:0098586)2.41562651
144serine family amino acid catabolic process (GO:0009071)2.41089434
145mesenchyme morphogenesis (GO:0072132)2.40927093
146positive regulation of epidermal cell differentiation (GO:0045606)2.40859707
147nucleotide-sugar metabolic process (GO:0009225)2.40846586
148sequestering of metal ion (GO:0051238)2.40240692
149IMP metabolic process (GO:0046040)2.40039151
150endocrine pancreas development (GO:0031018)2.39852795
151negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.39277492
152cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.39054781
153response to endoplasmic reticulum stress (GO:0034976)2.38611789
154positive regulation of cellular amide metabolic process (GO:0034250)2.38508727
155regulation of RIG-I signaling pathway (GO:0039535)2.38117107
156positive regulation of interferon-beta production (GO:0032728)2.37637698
157negative regulation of type 2 immune response (GO:0002829)2.37334402
158negative regulation of erythrocyte differentiation (GO:0045647)2.36667067
159interferon-gamma secretion (GO:0072643)2.35836877
160negative regulation of T cell mediated immunity (GO:0002710)2.35791426
161negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.35386946
162ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.35334392
163pinocytosis (GO:0006907)2.35184070
164high-density lipoprotein particle remodeling (GO:0034375)2.34954102
165respiratory burst (GO:0045730)2.34855653
166positive regulation of extracellular matrix organization (GO:1903055)2.34522067
167glycosphingolipid catabolic process (GO:0046479)2.33839581
168regulation of necrotic cell death (GO:0010939)2.33633101
169modulation by symbiont of host cellular process (GO:0044068)2.33523599
170regulation of toll-like receptor signaling pathway (GO:0034121)2.33184056
171positive regulation of transcription factor import into nucleus (GO:0042993)2.33154116
172negative regulation of myeloid cell apoptotic process (GO:0033033)2.30856301
173regulation of mast cell degranulation (GO:0043304)2.30829140
174fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30652568
175columnar/cuboidal epithelial cell development (GO:0002066)2.30069588
176regulation of podosome assembly (GO:0071801)2.29819395
177protein autoprocessing (GO:0016540)2.29676127
178protein N-linked glycosylation via asparagine (GO:0018279)2.29613282
179regulation of glucokinase activity (GO:0033131)2.28516329
180regulation of hexokinase activity (GO:1903299)2.28516329
181response to muramyl dipeptide (GO:0032495)2.28293939
182peptidyl-asparagine modification (GO:0018196)2.27970273
183positive regulation of NF-kappaB import into nucleus (GO:0042346)2.27787410
184sulfur amino acid catabolic process (GO:0000098)2.27745277
185regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27329391
186cysteine metabolic process (GO:0006534)2.27149190
187serine family amino acid metabolic process (GO:0009069)2.27101067
188neutrophil activation (GO:0042119)2.27005664
189renal system development (GO:0072001)2.26887511
190somite development (GO:0061053)2.26655620
191* response to unfolded protein (GO:0006986)2.26559296
192ribosome assembly (GO:0042255)2.25252596
193triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.25078020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.01326224
2E2F7_22180533_ChIP-Seq_HELA_Human3.96038496
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.21190007
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12133617
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.90427697
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.86458472
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75653684
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63493942
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40731034
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.37597268
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.28607075
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26213964
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.25924168
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.23154977
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.18799057
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.11957869
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07213439
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.01896891
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00504638
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99837784
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.98212264
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.96810996
23VDR_24763502_ChIP-Seq_THP-1_Human1.94333974
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.93497359
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93182720
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92622580
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91988625
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89329666
29GATA1_22025678_ChIP-Seq_K562_Human1.88021956
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85864370
31CLOCK_20551151_ChIP-Seq_293T_Human1.85654408
32LXR_22292898_ChIP-Seq_THP-1_Human1.84324267
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83309562
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81324171
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79587596
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78401551
37TCF7_22412390_ChIP-Seq_EML_Mouse1.77004228
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76175961
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73216264
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72520197
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70967554
42RACK7_27058665_Chip-Seq_MCF-7_Human1.68608641
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68073245
44MAF_26560356_Chip-Seq_TH1_Human1.66100729
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65434490
46MYC_22102868_ChIP-Seq_BL_Human1.65356160
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64977176
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63060763
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63019871
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62601313
51AR_21909140_ChIP-Seq_LNCAP_Human1.61540597
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61022516
53KDM2B_26808549_Chip-Seq_DND41_Human1.57004932
54* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56130827
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55968215
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55707935
57* SPI1_23127762_ChIP-Seq_K562_Human1.55449410
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54758201
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.54315410
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53533157
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52649223
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51281438
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.50432358
64* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50295803
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49076303
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48890386
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47499957
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47461012
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45372000
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.42601192
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41492914
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41353023
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.41040780
74* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37729676
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36547508
76UTX_26944678_Chip-Seq_JUKART_Human1.36543676
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36397544
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35976491
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35885194
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34617051
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.34301906
82ZNF263_19887448_ChIP-Seq_K562_Human1.34255649
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34133668
84VDR_23849224_ChIP-Seq_CD4+_Human1.32530182
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31054530
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30599227
87TFEB_21752829_ChIP-Seq_HELA_Human1.30567878
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29423171
89MAF_26560356_Chip-Seq_TH2_Human1.29071616
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27406032
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27149252
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26790025
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25640611
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25640611
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25352141
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24201032
97* SPI1_23547873_ChIP-Seq_NB4_Human1.23945761
98KDM2B_26808549_Chip-Seq_K562_Human1.22630731
99ATF3_27146783_Chip-Seq_COLON_Human1.22593091
100* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22451597
101DCP1A_22483619_ChIP-Seq_HELA_Human1.21461586
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21371161
103CIITA_25753668_ChIP-Seq_RAJI_Human1.21032379
104XRN2_22483619_ChIP-Seq_HELA_Human1.20310313
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19952052
106SCL_19346495_ChIP-Seq_HPC-7_Human1.19417781
107FOXP3_21729870_ChIP-Seq_TREG_Human1.18751948
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18322837
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18079977
110* GABP_19822575_ChIP-Seq_HepG2_Human1.18032753
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17141424
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16532261
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15440540
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.14364593
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14073136
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.13781976
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13699284
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13589388
119* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13531133
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.12896957
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12677180
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.12346145
123PU_27001747_Chip-Seq_BMDM_Mouse1.12262996
124VDR_21846776_ChIP-Seq_THP-1_Human1.11659696
125* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11642186
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11613243
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11524512
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11385102
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10913102
130KDM5A_27292631_Chip-Seq_BREAST_Human1.10871639
131CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09715018
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09536565
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08664696
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07029258
135UBF1/2_26484160_Chip-Seq_HMECs_Human1.06508443
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06091091
137MYB_26560356_Chip-Seq_TH2_Human1.05608448
138RUNX_20019798_ChIP-Seq_JUKART_Human1.05403315
139TP53_22127205_ChIP-Seq_IMR90_Human1.04881507
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04594470
141ELK1_19687146_ChIP-ChIP_HELA_Human1.03981108
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03834699
143E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03649941
144MYB_26560356_Chip-Seq_TH1_Human1.02702295
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02656507
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02643851
147NCOR1_26117541_ChIP-Seq_K562_Human1.02494988
148* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00634796
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99999252
150* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99867148
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99417498
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98320880
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97265187
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.95990383
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95636711
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94964484
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94118763
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93978489
159NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93802673
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92663772
161SRF_21415370_ChIP-Seq_HL-1_Mouse0.92400577
162RUNX1_22412390_ChIP-Seq_EML_Mouse0.92198587
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91339230
164SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91283045
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91144116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.49208829
2MP0003303_peritoneal_inflammation3.95764682
3MP0009780_abnormal_chondrocyte_physiolo3.90508524
4MP0003724_increased_susceptibility_to3.53912194
5MP0002139_abnormal_hepatobiliary_system3.05415851
6MP0002877_abnormal_melanocyte_morpholog3.02101231
7MP0003183_abnormal_peptide_metabolism2.93208039
8MP0005451_abnormal_body_composition2.89931732
9MP0008260_abnormal_autophagy2.74432693
10MP0005365_abnormal_bile_salt2.68968178
11MP0005220_abnormal_exocrine_pancreas2.54074676
12MP0006082_CNS_inflammation2.41629449
13MP0005085_abnormal_gallbladder_physiolo2.40260000
14MP0009785_altered_susceptibility_to2.34874270
15MP0005257_abnormal_intraocular_pressure2.26357843
16MP0010030_abnormal_orbit_morphology2.06689956
17MP0005025_abnormal_response_to2.02139006
18MP0003252_abnormal_bile_duct1.98737147
19MP0005360_urolithiasis1.93747266
20MP0009840_abnormal_foam_cell1.92877141
21MP0005000_abnormal_immune_tolerance1.91541421
22MP0002148_abnormal_hypersensitivity_rea1.87146746
23MP0003693_abnormal_embryo_hatching1.84535081
24MP0003191_abnormal_cellular_cholesterol1.78922851
25MP0008438_abnormal_cutaneous_collagen1.76778821
26MP0005387_immune_system_phenotype1.73926914
27MP0001790_abnormal_immune_system1.73926914
28MP0003091_abnormal_cell_migration1.73709007
29MP0001958_emphysema1.64503358
30MP0003453_abnormal_keratinocyte_physiol1.62955456
31MP0002138_abnormal_hepatobiliary_system1.61040033
32MP0002723_abnormal_immune_serum1.59433641
33MP0002452_abnormal_antigen_presenting1.59418027
34MP0004510_myositis1.56501688
35MP0008875_abnormal_xenobiotic_pharmacok1.56417038
36MP0003300_gastrointestinal_ulcer1.54604516
37MP0001800_abnormal_humoral_immune1.51803500
38MP0001944_abnormal_pancreas_morphology1.49439197
39MP0003075_altered_response_to1.48254168
40MP0003448_altered_tumor_morphology1.47075785
41MP0008007_abnormal_cellular_replicative1.43459835
42MP0006054_spinal_hemorrhage1.41499869
43MP0009278_abnormal_bone_marrow1.40399332
44MP0009764_decreased_sensitivity_to1.40360567
45MP0001819_abnormal_immune_cell1.40112012
46MP0003123_paternal_imprinting1.39429170
47MP0002420_abnormal_adaptive_immunity1.39330369
48MP0003806_abnormal_nucleotide_metabolis1.38854356
49MP0002166_altered_tumor_susceptibility1.37236319
50MP0001666_abnormal_nutrient_absorption1.35302132
51MP0005670_abnormal_white_adipose1.35211520
52MP0002254_reproductive_system_inflammat1.34473752
53MP0003705_abnormal_hypodermis_morpholog1.34390746
54MP0000604_amyloidosis1.33816322
55MP0003868_abnormal_feces_composition1.32642805
56MP0004808_abnormal_hematopoietic_stem1.31238082
57MP0000343_altered_response_to1.29452811
58MP0002089_abnormal_postnatal_growth/wei1.28935307
59MP0003195_calcinosis1.27541418
60MP0005164_abnormal_response_to1.27023341
61MP0002998_abnormal_bone_remodeling1.26375518
62MP0010329_abnormal_lipoprotein_level1.26045787
63MP0002693_abnormal_pancreas_physiology1.25820839
64MP0002405_respiratory_system_inflammati1.24726995
65MP0010234_abnormal_vibrissa_follicle1.24020557
66MP0009697_abnormal_copulation1.23748485
67MP0000609_abnormal_liver_physiology1.21949482
68MP0002332_abnormal_exercise_endurance1.20987211
69MP0005083_abnormal_biliary_tract1.20559701
70MP0002396_abnormal_hematopoietic_system1.20127799
71MP0003941_abnormal_skin_development1.17689905
72MP0008004_abnormal_stomach_pH1.17654156
73MP0005397_hematopoietic_system_phenotyp1.17451935
74MP0001545_abnormal_hematopoietic_system1.17451935
75MP0002928_abnormal_bile_duct1.17053694
76MP0003656_abnormal_erythrocyte_physiolo1.16913938
77MP0004858_abnormal_nervous_system1.16181985
78MP0005076_abnormal_cell_differentiation1.13196871
79MP0003221_abnormal_cardiomyocyte_apopto1.11515362
80MP0009643_abnormal_urine_homeostasis1.09707878
81MP0005310_abnormal_salivary_gland1.08043322
82MP0003111_abnormal_nucleus_morphology1.07208331
83MP0002009_preneoplasia1.06989745
84MP0004264_abnormal_extraembryonic_tissu1.06610641
85MP0005166_decreased_susceptibility_to1.05016059
86MP0003943_abnormal_hepatobiliary_system1.04797011
87MP0003436_decreased_susceptibility_to1.04579679
88MP0000716_abnormal_immune_system1.04182314
89MP0003077_abnormal_cell_cycle1.03383657
90MP0003329_amyloid_beta_deposits1.03341154
91MP0000428_abnormal_craniofacial_morphol1.02202460
92MP0005058_abnormal_lysosome_morphology1.01925075
93MP0000767_abnormal_smooth_muscle1.01366255
94MP0001542_abnormal_bone_strength1.00703208
95MP0004233_abnormal_muscle_weight1.00242756
96MP0001849_ear_inflammation0.99871806
97MP0005409_darkened_coat_color0.99733049
98MP0000858_altered_metastatic_potential0.99104717
99MP0005332_abnormal_amino_acid0.97827564
100MP0001873_stomach_inflammation0.97343368
101MP0001835_abnormal_antigen_presentation0.95035208
102MP0010368_abnormal_lymphatic_system0.94927989
103MP0000598_abnormal_liver_morphology0.94868359
104MP0002398_abnormal_bone_marrow0.92181329
105MP0005623_abnormal_meninges_morphology0.92017773
106MP0005390_skeleton_phenotype0.91705730
107MP0000371_diluted_coat_color0.90268330
108MP0004883_abnormal_blood_vessel0.90233036
109MP0004381_abnormal_hair_follicle0.89178407
110MP0001533_abnormal_skeleton_physiology0.89166575
111MP0001915_intracranial_hemorrhage0.88838722
112MP0005275_abnormal_skin_tensile0.88290550
113MP0010307_abnormal_tumor_latency0.87931496
114MP0005023_abnormal_wound_healing0.87562328
115MP0005319_abnormal_enzyme/_coenzyme0.87356362
116MP0002429_abnormal_blood_cell0.86316629
117MP0005464_abnormal_platelet_physiology0.84908456
118MP0002118_abnormal_lipid_homeostasis0.84777640
119MP0004185_abnormal_adipocyte_glucose0.84051888
120MP0001756_abnormal_urination0.84036200
121MP0002796_impaired_skin_barrier0.82678008
122MP0000685_abnormal_immune_system0.82513998
123MP0004272_abnormal_basement_membrane0.82104497
124MP0002722_abnormal_immune_system0.82096482
125MP0003828_pulmonary_edema0.81940612
126MP0009763_increased_sensitivity_to0.79728857
127MP0003866_abnormal_defecation0.79552958
128MP0002006_tumorigenesis0.79196279
129MP0003566_abnormal_cell_adhesion0.79091898
130MP0000490_abnormal_crypts_of0.79079891
131MP0008874_decreased_physiological_sensi0.79027128
132MP0009333_abnormal_splenocyte_physiolog0.78705371
133MP0001216_abnormal_epidermal_layer0.77950565
134MP0003279_aneurysm0.77844715
135MP0002419_abnormal_innate_immunity0.77801983
136MP0000003_abnormal_adipose_tissue0.77245593
137MP0005621_abnormal_cell_physiology0.75792875
138MP0002060_abnormal_skin_morphology0.75111033
139MP0010352_gastrointestinal_tract_polyps0.74996705
140MP0005408_hypopigmentation0.74566573
141MP0000465_gastrointestinal_hemorrhage0.73598648
142MP0005671_abnormal_response_to0.71378081
143MP0000350_abnormal_cell_proliferation0.69186527
144MP0008469_abnormal_protein_level0.69164553
145MP0001845_abnormal_inflammatory_respons0.68839129
146MP0002088_abnormal_embryonic_growth/wei0.68649819
147MP0000537_abnormal_urethra_morphology0.68600452
148MP0003984_embryonic_growth_retardation0.68282163
149MP0002078_abnormal_glucose_homeostasis0.68076031
150MP0005084_abnormal_gallbladder_morpholo0.67556676
151MP0001299_abnormal_eye_distance/0.67287547
152MP0003172_abnormal_lysosome_physiology0.67231431
153MP0005508_abnormal_skeleton_morphology0.66949830
154MP0001661_extended_life_span0.66747730
155MP0010155_abnormal_intestine_physiology0.65843132
156MP0003763_abnormal_thymus_physiology0.65337273
157MP0002086_abnormal_extraembryonic_tissu0.63784984
158MP0004947_skin_inflammation0.63554866
159MP0003186_abnormal_redox_activity0.62818675
160MP0001853_heart_inflammation0.62529689

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.07928309
2Abnormality of macrophages (HP:0004311)3.81022927
3Abnormality of the intrinsic pathway (HP:0010989)3.78690348
4Abnormality of liposaccharide metabolism (HP:0010968)3.75326400
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.75326400
6Abnormality of glycolipid metabolism (HP:0010969)3.75326400
7Abnormality of the lumbar spine (HP:0100712)3.60085515
8Neonatal short-limb short stature (HP:0008921)3.57201364
9Orchitis (HP:0100796)3.52592384
10Progressive muscle weakness (HP:0003323)3.40717340
11Myositis (HP:0100614)3.25323854
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.24203305
13Recurrent abscess formation (HP:0002722)3.23273635
14Recurrent bacterial skin infections (HP:0005406)3.19528309
15Hypoglycemic coma (HP:0001325)3.17195345
16Retrobulbar optic neuritis (HP:0100654)3.10919039
17Optic neuritis (HP:0100653)3.10919039
18Peritonitis (HP:0002586)3.09964782
19Protrusio acetabuli (HP:0003179)3.08227097
20Vertebral compression fractures (HP:0002953)2.96393326
21Abnormality of the common coagulation pathway (HP:0010990)2.90855539
22Intrahepatic cholestasis (HP:0001406)2.87534790
23Neonatal death (HP:0003811)2.82498327
24Partial duplication of thumb phalanx (HP:0009944)2.77835029
25Hyperglycemia (HP:0003074)2.73937101
26Aortic aneurysm (HP:0004942)2.73649866
27Hyperinsulinemic hypoglycemia (HP:0000825)2.69832236
28Loss of speech (HP:0002371)2.67986100
29Thrombocytosis (HP:0001894)2.66786977
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66548298
31Recurrent gram-negative bacterial infections (HP:0005420)2.63592894
32Xanthomatosis (HP:0000991)2.60223688
33Hypoglycemic seizures (HP:0002173)2.53681469
34Degeneration of anterior horn cells (HP:0002398)2.49672025
35Abnormality of the anterior horn cell (HP:0006802)2.49672025
36Gastrointestinal infarctions (HP:0005244)2.48807344
37Spondylolisthesis (HP:0003302)2.48340769
38Hepatocellular carcinoma (HP:0001402)2.46660114
39Ureteral duplication (HP:0000073)2.44196629
40Interstitial pulmonary disease (HP:0006530)2.42577038
41Thin bony cortex (HP:0002753)2.42258798
42Prolonged partial thromboplastin time (HP:0003645)2.41764065
43Abnormality of the costochondral junction (HP:0000919)2.40485473
44Partial duplication of the phalanx of hand (HP:0009999)2.39535019
45Subacute progressive viral hepatitis (HP:0006572)2.37856761
46Dysostosis multiplex (HP:0000943)2.35457160
47Hyperglycinemia (HP:0002154)2.34894044
48Abnormality of complement system (HP:0005339)2.34765911
49Amyloidosis (HP:0011034)2.34013220
50Infantile muscular hypotonia (HP:0008947)2.33957591
51Vacuolated lymphocytes (HP:0001922)2.30798894
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30083484
53Gingivitis (HP:0000230)2.29514603
54Urinary glycosaminoglycan excretion (HP:0003541)2.29208797
55Mucopolysacchariduria (HP:0008155)2.29208797
56Conjugated hyperbilirubinemia (HP:0002908)2.26029565
57Dilatation of the ascending aorta (HP:0005111)2.25926165
58Flat acetabular roof (HP:0003180)2.24774565
59Aplasia involving bones of the upper limbs (HP:0009823)2.24616567
60Aplasia of the phalanges of the hand (HP:0009802)2.24616567
61Aplasia involving bones of the extremities (HP:0009825)2.24616567
62Generalized aminoaciduria (HP:0002909)2.24462142
63Micronodular cirrhosis (HP:0001413)2.24306435
64Abnormality of the pancreatic islet cells (HP:0006476)2.24292429
65Abnormality of endocrine pancreas physiology (HP:0012093)2.24292429
66Deep venous thrombosis (HP:0002625)2.22466518
67Cellulitis (HP:0100658)2.21319153
68Esophageal varix (HP:0002040)2.19744661
69Joint hemorrhage (HP:0005261)2.19669635
70Mediastinal lymphadenopathy (HP:0100721)2.18196166
71Menorrhagia (HP:0000132)2.17272749
72Nonimmune hydrops fetalis (HP:0001790)2.16702778
73Testicular atrophy (HP:0000029)2.13996132
74Systemic lupus erythematosus (HP:0002725)2.13615276
75Premature rupture of membranes (HP:0001788)2.12216365
76Gout (HP:0001997)2.11730643
77Cervical subluxation (HP:0003308)2.11634929
78Myocardial infarction (HP:0001658)2.09493674
79Long toe (HP:0010511)2.09052568
80Short nail (HP:0001799)2.08833729
81Elevated erythrocyte sedimentation rate (HP:0003565)2.08493257
82Generalized amyotrophy (HP:0003700)2.08354824
83Increased connective tissue (HP:0009025)2.07067349
84Achilles tendon contracture (HP:0001771)2.06137178
85Increased cerebral lipofuscin (HP:0011813)2.05501614
86Mitral stenosis (HP:0001718)2.04845911
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.04615317
88Osteolytic defects of the hand bones (HP:0009699)2.04615317
89Abnormality of pyrimidine metabolism (HP:0004353)2.04330075
90Insulin resistance (HP:0000855)2.03644029
91Symptomatic seizures (HP:0011145)2.03295113
92Hypoplastic scapulae (HP:0000882)2.03197314
93Aplasia/Hypoplasia of the scapulae (HP:0006713)2.03197314
94Keratoconjunctivitis sicca (HP:0001097)2.03058109
95Late onset (HP:0003584)2.02973428
96Atrophic scars (HP:0001075)2.00727729
97Cerebral aneurysm (HP:0004944)2.00660635
98Recurrent corneal erosions (HP:0000495)1.99167738
99Vascular tortuosity (HP:0004948)1.99146090
100Gonadal dysgenesis (HP:0000133)1.99125851
101Hemorrhage of the eye (HP:0011885)1.98852192
102Increased serum ferritin (HP:0003281)1.97566307
103Entropion (HP:0000621)1.97055212
104Distal lower limb amyotrophy (HP:0008944)1.97022620
105Cerebral inclusion bodies (HP:0100314)1.96910757
106Hypobetalipoproteinemia (HP:0003563)1.96601036
107Abnormality of polysaccharide metabolism (HP:0011012)1.96053265
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96053265
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96053265
110Complement deficiency (HP:0004431)1.96006186
111Recurrent skin infections (HP:0001581)1.95681566
112Malnutrition (HP:0004395)1.95432159
113Genu recurvatum (HP:0002816)1.95026454
114Arterial tortuosity (HP:0005116)1.94548433
115Stomatitis (HP:0010280)1.93860590
116Spontaneous hematomas (HP:0007420)1.93615055
117Ankle contracture (HP:0006466)1.92712658
118Recurrent fungal infections (HP:0002841)1.92245526
119Hyperglycinuria (HP:0003108)1.90554793
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90507655
121Abnormality of the distal phalanges of the toes (HP:0010182)1.90070769
122Arterial thrombosis (HP:0004420)1.89902945
123Abnormality of the peritoneum (HP:0002585)1.89814910
124Abnormality of the Achilles tendon (HP:0005109)1.89663443
125Hyperlipoproteinemia (HP:0010980)1.89221781
126Ketosis (HP:0001946)1.87714536
127Abnormality of nucleobase metabolism (HP:0010932)1.87345080
128Urticaria (HP:0001025)1.87172026
129Insulin-resistant diabetes mellitus (HP:0000831)1.87006892
130Upper motor neuron abnormality (HP:0002127)1.86882296
131Aortic dissection (HP:0002647)1.86513450
132Neurofibrillary tangles (HP:0002185)1.86314392
133Fat malabsorption (HP:0002630)1.86186881
134Blue sclerae (HP:0000592)1.85474747
135Visceral angiomatosis (HP:0100761)1.85426831
136Slow saccadic eye movements (HP:0000514)1.84486233
137Hematochezia (HP:0002573)1.84456879
138Gingival bleeding (HP:0000225)1.82228491
139Camptodactyly of toe (HP:0001836)1.82184174
140Obstructive lung disease (HP:0006536)1.80585583
141Chronic obstructive pulmonary disease (HP:0006510)1.80585583
142Aortic regurgitation (HP:0001659)1.80492575
143Bone pain (HP:0002653)1.79614497
144Abnormality of purine metabolism (HP:0004352)1.78852582
145Syringomyelia (HP:0003396)1.78829850
146Spinal cord lesions (HP:0100561)1.78829850
147Glucose intolerance (HP:0000833)1.78699415
148Adactyly (HP:0009776)1.78376807
149Segmental peripheral demyelination/remyelination (HP:0003481)1.78084324
150Abnormality of glycine metabolism (HP:0010895)1.77902228
151Abnormality of serine family amino acid metabolism (HP:0010894)1.77902228
152Keratoconjunctivitis (HP:0001096)1.77660499
153Vasculitis (HP:0002633)1.76684803
154Coronal craniosynostosis (HP:0004440)1.75208887
155Pathologic fracture (HP:0002756)1.74905060
156Hemangiomatosis (HP:0007461)1.74462571
157Prominent metopic ridge (HP:0005487)1.74339596
158Impaired platelet aggregation (HP:0003540)1.73945348
159Abnormal platelet function (HP:0011869)1.73945348
160Megalencephaly (HP:0001355)1.73940519
161Ovoid vertebral bodies (HP:0003300)1.73150343
162Abnormality of the pericardium (HP:0001697)1.72700301
163Episodic fever (HP:0001954)1.72532768
164Alopecia of scalp (HP:0002293)1.72060959
165Wormian bones (HP:0002645)1.72052031
16611 pairs of ribs (HP:0000878)1.71960676
167Pancreatic islet-cell hyperplasia (HP:0004510)1.71942069
168Increased IgE level (HP:0003212)1.71853212
169Asymmetric septal hypertrophy (HP:0001670)1.71257572
170Hyperbilirubinemia (HP:0002904)1.70965080
171Abnormality of the middle phalanges of the toes (HP:0010183)1.70791459
172Striae distensae (HP:0001065)1.70258596
173Fragile skin (HP:0001030)1.70129241
174Aneurysm (HP:0002617)1.69961505
175Aseptic necrosis (HP:0010885)1.67869710
176Recurrent viral infections (HP:0004429)1.67750371
177Anorexia (HP:0002039)1.66323114
178Tetraparesis (HP:0002273)1.65871564
179Polycythemia (HP:0001901)1.65728833
180Persistence of primary teeth (HP:0006335)1.64788312
181Distal lower limb muscle weakness (HP:0009053)1.62520554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.45952140
2IRAK33.77028823
3TESK23.71774521
4ERN13.14578593
5PRPF4B2.83338510
6FGFR32.77170967
7CDK82.69837626
8BCKDK2.48515444
9FRK2.28247243
10EPHB12.10880895
11RIPK42.07012251
12TAOK22.06981704
13TAOK32.06922909
14NME21.98103083
15BLK1.95828901
16PASK1.94227910
17BRSK21.87053525
18MKNK21.84134362
19KSR21.66744546
20FLT31.63606749
21TAOK11.63146352
22INSRR1.62902572
23SCYL21.61608666
24AKT31.60674165
25MAP2K31.58341214
26RPS6KA41.57387252
27NEK91.55870666
28IRAK41.52727285
29MAP3K11.50166524
30SMG11.49307260
31ICK1.49294977
32TESK11.47265435
33TYK21.41936713
34MAP3K131.35606302
35TRIB31.32967383
36MAP3K31.32320008
37MAP3K141.31124470
38MOS1.29306595
39SIK31.24913430
40PKN21.22973692
41PIM21.21006279
42NEK21.19024872
43FGR1.18468584
44MAP3K61.17865948
45GRK61.17304295
46FGFR11.15994047
47CDK41.14788614
48MATK1.12143079
49MAP4K11.11604628
50TGFBR21.09840727
51DYRK31.09282554
52CDC42BPA1.07215906
53EPHA21.05824906
54PRKD21.05730649
55JAK31.04324875
56PIK3CG1.04028327
57SIK11.03334771
58LATS21.03054978
59RIPK11.02329839
60MKNK11.01129143
61HIPK20.99612507
62LATS10.97169096
63ARAF0.94447781
64CDK90.94422255
65DDR20.92640499
66MST1R0.92267458
67MAP3K20.92202426
68EIF2AK30.91572918
69NLK0.90310651
70STK100.89956413
71MELK0.89711977
72NUAK10.89613673
73KSR10.88989564
74MAP3K100.88958856
75PTK60.88526108
76TTN0.87902821
77BTK0.87098149
78JAK10.86065249
79CHUK0.85250924
80TEC0.83752011
81MARK20.83320408
82TLK10.83121007
83GRK70.83065431
84ZAP700.81216799
85BMPR20.80042061
86TIE10.79456720
87IRAK20.78031272
88ERBB30.77542118
89KIT0.75691842
90ZAK0.74471979
91HCK0.73723833
92PDPK10.73363815
93CDK60.72717592
94FGFR40.71540418
95PIM10.70569012
96IRAK10.66300879
97RAF10.65627547
98ATR0.65557265
99SRPK10.64959747
100MARK30.64887945
101PTK20.64805026
102LMTK20.64493494
103TXK0.64418753
104PRKD30.63708777
105DYRK1B0.63260372
106STK380.63120149
107AURKB0.62397451
108YES10.62093907
109LRRK20.60365311
110TBK10.60224010
111STK160.59466677
112MAPK110.58958647
113MAP3K70.58013896
114BMX0.55982559
115CLK10.55830711
116IKBKB0.55440604
117PDGFRB0.53904208
118WEE10.53780655
119JAK20.52136776
120EPHA30.51952845
121MAP3K110.51659732
122LYN0.50938117
123PLK10.50455603
124PRKG20.50179608
125CDK70.49795411
126TSSK60.49047187
127FES0.48969145
128IKBKE0.48679778
129LCK0.48271025
130MAP3K80.47443566
131TGFBR10.46423750
132PDGFRA0.45930112
133MTOR0.44644314
134MAPKAPK20.44479408
135RET0.43782193
136BRD40.43005524
137PDK10.42290179
138SIK20.41748060
139IGF1R0.41576882
140RPS6KA20.40952644
141STK30.40105458
142ABL20.39657678
143STK40.39532100
144TRPM70.38543328
145PAK40.38501209
146TNK20.38498016
147CSK0.38393324
148CDK120.37303898
149CSF1R0.37058396
150NEK60.35437978
151BRSK10.34521912
152SYK0.33825057
153MAP3K50.32799364
154MAPK150.32172549

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.31741921
2Protein export_Homo sapiens_hsa030603.29119017
3Vitamin B6 metabolism_Homo sapiens_hsa007502.92742050
4Folate biosynthesis_Homo sapiens_hsa007902.84042452
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.62301792
6Selenocompound metabolism_Homo sapiens_hsa004502.42790979
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34280892
8Osteoclast differentiation_Homo sapiens_hsa043802.33883171
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.20567848
10Drug metabolism - other enzymes_Homo sapiens_hsa009832.05850623
11Malaria_Homo sapiens_hsa051441.96151075
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81104907
13Acute myeloid leukemia_Homo sapiens_hsa052211.78176976
14Complement and coagulation cascades_Homo sapiens_hsa046101.76600281
15TNF signaling pathway_Homo sapiens_hsa046681.73313274
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70814858
17Tuberculosis_Homo sapiens_hsa051521.69173086
18One carbon pool by folate_Homo sapiens_hsa006701.65140424
19Hepatitis C_Homo sapiens_hsa051601.64203422
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56017400
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55865542
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55707321
23Tryptophan metabolism_Homo sapiens_hsa003801.55700389
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54632493
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54243334
26Shigellosis_Homo sapiens_hsa051311.53083543
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52375400
28N-Glycan biosynthesis_Homo sapiens_hsa005101.50278135
29Toxoplasmosis_Homo sapiens_hsa051451.50134420
30B cell receptor signaling pathway_Homo sapiens_hsa046621.49831087
31Salmonella infection_Homo sapiens_hsa051321.46067578
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43028309
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42371862
34Pertussis_Homo sapiens_hsa051331.40454512
35Staphylococcus aureus infection_Homo sapiens_hsa051501.40235964
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33554051
37Pancreatic cancer_Homo sapiens_hsa052121.33331357
38Sulfur metabolism_Homo sapiens_hsa009201.32975574
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32552337
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30777439
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27523992
42Phagosome_Homo sapiens_hsa041451.25188510
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.25055505
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25022348
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25021033
46African trypanosomiasis_Homo sapiens_hsa051431.23206703
47Lysosome_Homo sapiens_hsa041421.21320291
48Amoebiasis_Homo sapiens_hsa051461.20410757
49Chemokine signaling pathway_Homo sapiens_hsa040621.19811908
50Bladder cancer_Homo sapiens_hsa052191.18113375
51Non-small cell lung cancer_Homo sapiens_hsa052231.17576126
52Fatty acid degradation_Homo sapiens_hsa000711.15752583
53Antigen processing and presentation_Homo sapiens_hsa046121.15626072
54Peroxisome_Homo sapiens_hsa041461.15138187
55ABC transporters_Homo sapiens_hsa020101.14297063
56Renal cell carcinoma_Homo sapiens_hsa052111.12033712
57Base excision repair_Homo sapiens_hsa034101.10676394
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09952934
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09232293
60Starch and sucrose metabolism_Homo sapiens_hsa005001.08198476
61Prion diseases_Homo sapiens_hsa050201.07544261
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.06496362
63DNA replication_Homo sapiens_hsa030301.06175275
64VEGF signaling pathway_Homo sapiens_hsa043701.02053055
65RNA transport_Homo sapiens_hsa030131.01066307
66Sulfur relay system_Homo sapiens_hsa041221.00405911
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.98820472
68Galactose metabolism_Homo sapiens_hsa000520.98420991
69RNA polymerase_Homo sapiens_hsa030200.96490397
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96167762
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95085512
72Viral myocarditis_Homo sapiens_hsa054160.94916424
73Caffeine metabolism_Homo sapiens_hsa002320.94508954
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92707546
75p53 signaling pathway_Homo sapiens_hsa041150.90259036
76Chemical carcinogenesis_Homo sapiens_hsa052040.89414082
77Nitrogen metabolism_Homo sapiens_hsa009100.88294829
78T cell receptor signaling pathway_Homo sapiens_hsa046600.87560917
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87471955
80Notch signaling pathway_Homo sapiens_hsa043300.87022519
81Endocytosis_Homo sapiens_hsa041440.87004645
82Vitamin digestion and absorption_Homo sapiens_hsa049770.86404999
83Hematopoietic cell lineage_Homo sapiens_hsa046400.86399574
84Other glycan degradation_Homo sapiens_hsa005110.85934586
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.85749753
86Endometrial cancer_Homo sapiens_hsa052130.85310105
87Legionellosis_Homo sapiens_hsa051340.85190569
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.84954392
89Thyroid cancer_Homo sapiens_hsa052160.83775903
90Vibrio cholerae infection_Homo sapiens_hsa051100.83575396
91Rheumatoid arthritis_Homo sapiens_hsa053230.83335802
92Sphingolipid metabolism_Homo sapiens_hsa006000.83198987
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82940880
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82315616
95Proteoglycans in cancer_Homo sapiens_hsa052050.80977916
96Pyrimidine metabolism_Homo sapiens_hsa002400.80382201
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78987413
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77890946
99Allograft rejection_Homo sapiens_hsa053300.77608670
100Histidine metabolism_Homo sapiens_hsa003400.77187066
101Pentose phosphate pathway_Homo sapiens_hsa000300.77077909
102PPAR signaling pathway_Homo sapiens_hsa033200.75053163
103beta-Alanine metabolism_Homo sapiens_hsa004100.74119546
104Focal adhesion_Homo sapiens_hsa045100.73503706
105Cell cycle_Homo sapiens_hsa041100.73386823
106Graft-versus-host disease_Homo sapiens_hsa053320.72828630
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72014051
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.70966286
109Arginine biosynthesis_Homo sapiens_hsa002200.68039023
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66105893
111Lysine degradation_Homo sapiens_hsa003100.66096676
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.65641308
113HIF-1 signaling pathway_Homo sapiens_hsa040660.65532556
114Insulin resistance_Homo sapiens_hsa049310.62489003
115Fat digestion and absorption_Homo sapiens_hsa049750.62226892
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.59795421
117GnRH signaling pathway_Homo sapiens_hsa049120.59693642
118Autoimmune thyroid disease_Homo sapiens_hsa053200.58888756
119ErbB signaling pathway_Homo sapiens_hsa040120.58312991
120Dorso-ventral axis formation_Homo sapiens_hsa043200.57522487
121Leishmaniasis_Homo sapiens_hsa051400.57501431
122Measles_Homo sapiens_hsa051620.54601977
123MicroRNAs in cancer_Homo sapiens_hsa052060.54456442
124Glioma_Homo sapiens_hsa052140.54222820
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54141441
126Epstein-Barr virus infection_Homo sapiens_hsa051690.53995802
127Mismatch repair_Homo sapiens_hsa034300.53817945
128Biosynthesis of amino acids_Homo sapiens_hsa012300.52710627
129Apoptosis_Homo sapiens_hsa042100.52273998
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.50751499
131Insulin signaling pathway_Homo sapiens_hsa049100.50624857
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.50379503
133Glutathione metabolism_Homo sapiens_hsa004800.49711005
134FoxO signaling pathway_Homo sapiens_hsa040680.49247110
135mTOR signaling pathway_Homo sapiens_hsa041500.48880957
136Fanconi anemia pathway_Homo sapiens_hsa034600.48852934
137Fatty acid metabolism_Homo sapiens_hsa012120.47633912
138Platelet activation_Homo sapiens_hsa046110.46030108
139Small cell lung cancer_Homo sapiens_hsa052220.46012505
140Arginine and proline metabolism_Homo sapiens_hsa003300.45976752
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.45006617
142Homologous recombination_Homo sapiens_hsa034400.44692396
143Herpes simplex infection_Homo sapiens_hsa051680.44676132
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44670754
145Purine metabolism_Homo sapiens_hsa002300.43607565
146Chronic myeloid leukemia_Homo sapiens_hsa052200.42352212
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42215465
148Hepatitis B_Homo sapiens_hsa051610.42156976
149Fructose and mannose metabolism_Homo sapiens_hsa000510.41707147
150Phenylalanine metabolism_Homo sapiens_hsa003600.41702680
151Retinol metabolism_Homo sapiens_hsa008300.41576458
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41441342
153Prolactin signaling pathway_Homo sapiens_hsa049170.41037073
154Prostate cancer_Homo sapiens_hsa052150.40936699
155Viral carcinogenesis_Homo sapiens_hsa052030.37323580
156Spliceosome_Homo sapiens_hsa030400.35637056
157Regulation of autophagy_Homo sapiens_hsa041400.33447144
158Tyrosine metabolism_Homo sapiens_hsa003500.33015525
159HTLV-I infection_Homo sapiens_hsa051660.32968459
160mRNA surveillance pathway_Homo sapiens_hsa030150.32575906
161Influenza A_Homo sapiens_hsa051640.32384991
162Non-homologous end-joining_Homo sapiens_hsa034500.30880358
163Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30576604
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29632298

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »