TOR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.87691116
2neutrophil activation involved in immune response (GO:0002283)4.84426942
3response to peptidoglycan (GO:0032494)4.83044866
4DNA deamination (GO:0045006)4.64787392
5nucleobase biosynthetic process (GO:0046112)4.59325305
6folic acid metabolic process (GO:0046655)4.44878419
7immunoglobulin mediated immune response (GO:0016064)4.40305966
8positive regulation of gamma-delta T cell activation (GO:0046645)4.18709028
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03000498
10negative regulation of cell killing (GO:0031342)4.03000498
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01809316
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.01809316
13modulation by symbiont of host immune response (GO:0052553)4.01809316
14positive regulation by symbiont of host defense response (GO:0052509)4.01809316
15modulation by symbiont of host defense response (GO:0052031)4.01809316
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01809316
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97722577
18negative regulation of interleukin-12 production (GO:0032695)3.91117081
19regulation of mast cell degranulation (GO:0043304)3.80581998
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80524224
21glycine metabolic process (GO:0006544)3.69847676
22antigen processing and presentation of endogenous antigen (GO:0019883)3.68732604
23respiratory burst (GO:0045730)3.53081170
24negative regulation of erythrocyte differentiation (GO:0045647)3.51857539
25detection of bacterium (GO:0016045)3.51775824
26detection of other organism (GO:0098543)3.51253864
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51174287
28regulation of myeloid leukocyte mediated immunity (GO:0002886)3.44964373
29regulation of B cell receptor signaling pathway (GO:0050855)3.43509744
30neutrophil activation (GO:0042119)3.42005396
31regulation of mast cell activation involved in immune response (GO:0033006)3.38247495
32proteasome assembly (GO:0043248)3.37072238
33response to host immune response (GO:0052572)3.36073762
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36073762
35NIK/NF-kappaB signaling (GO:0038061)3.32895516
36folic acid transport (GO:0015884)3.32278297
37regulation of leukocyte degranulation (GO:0043300)3.31147639
38DNA replication checkpoint (GO:0000076)3.28814336
39granulocyte activation (GO:0036230)3.25474907
40positive regulation of mast cell activation (GO:0033005)3.25307878
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24177933
42positive regulation of B cell differentiation (GO:0045579)3.23583324
43B cell mediated immunity (GO:0019724)3.22855999
44formation of translation preinitiation complex (GO:0001731)3.19744373
45L-methionine salvage (GO:0071267)3.19368096
46L-methionine biosynthetic process (GO:0071265)3.19368096
47amino acid salvage (GO:0043102)3.19368096
48response to muramyl dipeptide (GO:0032495)3.17592054
49positive regulation of mast cell degranulation (GO:0043306)3.15749776
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.15749776
51purine deoxyribonucleotide catabolic process (GO:0009155)3.11750926
52macrophage activation involved in immune response (GO:0002281)3.11446957
53sulfur amino acid biosynthetic process (GO:0000097)3.09811468
54serine family amino acid biosynthetic process (GO:0009070)3.07364910
55serine family amino acid catabolic process (GO:0009071)3.06335420
56myeloid cell activation involved in immune response (GO:0002275)3.05427534
57folic acid-containing compound biosynthetic process (GO:0009396)3.03855844
58ribosome biogenesis (GO:0042254)3.03277557
59S-adenosylmethionine metabolic process (GO:0046500)3.03003914
60deoxyribonucleotide catabolic process (GO:0009264)3.01071139
61cellular extravasation (GO:0045123)2.98195915
62negative regulation of B cell apoptotic process (GO:0002903)2.97809296
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97535085
64vitamin transmembrane transport (GO:0035461)2.96251729
65leukocyte aggregation (GO:0070486)2.95849282
66ribosome assembly (GO:0042255)2.95535675
67leukocyte degranulation (GO:0043299)2.95335245
68pyrimidine nucleotide catabolic process (GO:0006244)2.95101240
69regulation of mast cell activation (GO:0033003)2.94722270
70methionine biosynthetic process (GO:0009086)2.92501778
71regulation of regulated secretory pathway (GO:1903305)2.91429861
72deoxyribose phosphate catabolic process (GO:0046386)2.91277529
73negative regulation of phagocytosis (GO:0050765)2.90689454
74negative regulation of myeloid cell apoptotic process (GO:0033033)2.90391764
75rRNA modification (GO:0000154)2.89660413
76response to host (GO:0075136)2.88034815
77response to host defenses (GO:0052200)2.88034815
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88034815
79DNA strand elongation involved in DNA replication (GO:0006271)2.87681477
80pantothenate metabolic process (GO:0015939)2.87384254
81serine family amino acid metabolic process (GO:0009069)2.87090719
82cellular metabolic compound salvage (GO:0043094)2.85777443
83nucleoside salvage (GO:0043174)2.85338320
84telomere maintenance via semi-conservative replication (GO:0032201)2.84944475
85actin nucleation (GO:0045010)2.84306745
86GDP-mannose metabolic process (GO:0019673)2.83327961
87methionine metabolic process (GO:0006555)2.83030916
88ribosomal small subunit assembly (GO:0000028)2.82806124
89folic acid-containing compound metabolic process (GO:0006760)2.82673049
90mitotic metaphase plate congression (GO:0007080)2.82488138
91DNA strand elongation (GO:0022616)2.81480046
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81386516
93termination of RNA polymerase III transcription (GO:0006386)2.81136398
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.81136398
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79661675
96modulation by virus of host process (GO:0019054)2.74569386
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74352377
98base-excision repair, AP site formation (GO:0006285)2.73695317
99DNA replication initiation (GO:0006270)2.72663732
100detection of external biotic stimulus (GO:0098581)2.71179795
101protein retention in ER lumen (GO:0006621)2.70400864
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68427363
103Golgi transport vesicle coating (GO:0048200)2.67825013
104COPI coating of Golgi vesicle (GO:0048205)2.67825013
105L-serine metabolic process (GO:0006563)2.66722680
106maturation of SSU-rRNA (GO:0030490)2.66305050
107proline biosynthetic process (GO:0006561)2.65146439
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64443630
109negative regulation of lymphocyte mediated immunity (GO:0002707)2.64196245
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63998610
111positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.63110229
112cysteine metabolic process (GO:0006534)2.62680120
113negative regulation of leukocyte mediated immunity (GO:0002704)2.62679021
114regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62554976
115positive thymic T cell selection (GO:0045059)2.62458154
116neutrophil mediated immunity (GO:0002446)2.60599049
117regulation of gamma-delta T cell activation (GO:0046643)2.60408391
118pentose metabolic process (GO:0019321)2.60058671
119intestinal cholesterol absorption (GO:0030299)2.59990004
120negative regulation of innate immune response (GO:0045824)2.59378930
121purine nucleotide salvage (GO:0032261)2.59053315
122termination of RNA polymerase I transcription (GO:0006363)2.58816631
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58804896
124regulation of defense response to virus by virus (GO:0050690)2.57923852
125GMP metabolic process (GO:0046037)2.56600008
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56197938
127interferon-gamma-mediated signaling pathway (GO:0060333)2.56059500
128homocysteine metabolic process (GO:0050667)2.55763700
129deoxyribose phosphate biosynthetic process (GO:0046385)2.55719233
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.55719233
131positive regulation of protein homooligomerization (GO:0032464)2.55308727
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.54706728
133amino sugar catabolic process (GO:0046348)2.53048060
134pseudouridine synthesis (GO:0001522)2.52009647
135UDP-N-acetylglucosamine metabolic process (GO:0006047)2.51424308
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51317115
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50975938
138peptidyl-arginine omega-N-methylation (GO:0035247)2.50503157
139phagosome maturation (GO:0090382)2.50363799
140ribonucleoprotein complex biogenesis (GO:0022613)2.50178479
141positive regulation of antigen processing and presentation (GO:0002579)2.50153410
142pteridine-containing compound metabolic process (GO:0042558)2.49860709
143telomere maintenance via recombination (GO:0000722)2.49204532
144regulation of T cell tolerance induction (GO:0002664)2.48766055
145regulation of antigen processing and presentation (GO:0002577)2.48135236
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47642899
147L-phenylalanine metabolic process (GO:0006558)2.47642899
148regulation of B cell apoptotic process (GO:0002902)2.47415467
149autophagic vacuole fusion (GO:0000046)2.47234941
150pteridine-containing compound biosynthetic process (GO:0042559)2.45687872
151regulation of B cell differentiation (GO:0045577)2.45528400
152glycosphingolipid catabolic process (GO:0046479)2.45507674
153transcription elongation from RNA polymerase I promoter (GO:0006362)2.44935349
154defense response to protozoan (GO:0042832)2.44419823
155metallo-sulfur cluster assembly (GO:0031163)2.44307336
156iron-sulfur cluster assembly (GO:0016226)2.44307336
157negative regulation of T cell mediated immunity (GO:0002710)2.44241712
158tetrahydrofolate metabolic process (GO:0046653)2.43684383
159indole-containing compound catabolic process (GO:0042436)2.43540900
160indolalkylamine catabolic process (GO:0046218)2.43540900
161tryptophan catabolic process (GO:0006569)2.43540900
162positive regulation of regulated secretory pathway (GO:1903307)2.42717864
163detection of biotic stimulus (GO:0009595)2.42564580
164positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42410469
165nucleotide salvage (GO:0043173)2.42289840
166transcription from RNA polymerase I promoter (GO:0006360)2.41495843
167one-carbon metabolic process (GO:0006730)2.41420351
168rRNA methylation (GO:0031167)2.40401260
169aspartate family amino acid biosynthetic process (GO:0009067)2.39947372
170antigen processing and presentation via MHC class Ib (GO:0002475)2.39292973
171aromatic amino acid family catabolic process (GO:0009074)2.39229045
172rRNA processing (GO:0006364)2.38577730
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38406871
174antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38406871
175pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.37950352
176guanosine-containing compound biosynthetic process (GO:1901070)2.37597661
1777-methylguanosine mRNA capping (GO:0006370)2.36905231
178sulfur amino acid catabolic process (GO:0000098)2.36849455
179erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.36759180
180L-phenylalanine catabolic process (GO:0006559)2.36759180
181negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.36736596
182negative regulation of DNA-templated transcription, elongation (GO:0032785)2.36736596
183pyrimidine nucleoside salvage (GO:0043097)2.36184545
184pyrimidine-containing compound salvage (GO:0008655)2.36184545
185regulation of translation in response to stress (GO:0043555)2.36057981
186triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.35854597
187peptidyl-histidine modification (GO:0018202)2.35379694
188tryptophan metabolic process (GO:0006568)2.34196828
189sulfur amino acid metabolic process (GO:0000096)2.33672069
190N-acetylneuraminate metabolic process (GO:0006054)2.33219233
191ribosomal large subunit biogenesis (GO:0042273)2.32666113
192regulation of nuclear cell cycle DNA replication (GO:0033262)2.32029976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.07363187
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.50361934
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27964563
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15708862
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.10148122
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02364128
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78304546
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.75817975
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64506269
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.61399947
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54309378
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50667949
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.50460149
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43960433
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.24552171
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19402974
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11245211
18VDR_24763502_ChIP-Seq_THP-1_Human2.05684427
19* LXR_22292898_ChIP-Seq_THP-1_Human2.04989773
20* VDR_23849224_ChIP-Seq_CD4+_Human2.03386327
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02924720
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00327144
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00029186
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95050986
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.93603823
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89551345
27GABP_19822575_ChIP-Seq_HepG2_Human1.88365369
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87409193
29* XRN2_22483619_ChIP-Seq_HELA_Human1.86839860
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.85563569
31DCP1A_22483619_ChIP-Seq_HELA_Human1.84280781
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83650717
33UTX_26944678_Chip-Seq_JUKART_Human1.83629056
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83024404
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81554547
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81421441
37MAF_26560356_Chip-Seq_TH1_Human1.80916994
38FOXP3_21729870_ChIP-Seq_TREG_Human1.79731509
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79718686
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78755799
41MAF_26560356_Chip-Seq_TH2_Human1.73470576
42BCL6_27268052_Chip-Seq_Bcells_Human1.73036809
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73020807
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72905063
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.72708846
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69061613
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.68154385
48MYC_22102868_ChIP-Seq_BL_Human1.66731301
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.65332230
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64723584
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.61349927
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60253295
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59211710
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.59053022
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58752826
56* P68_20966046_ChIP-Seq_HELA_Human1.58746154
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58246680
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57332813
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55349718
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54728381
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54158508
62* BCOR_27268052_Chip-Seq_Bcells_Human1.53972800
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.53372516
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52726519
65KDM2B_26808549_Chip-Seq_DND41_Human1.48053528
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47967465
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47336697
68CIITA_25753668_ChIP-Seq_RAJI_Human1.46807130
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44523257
70* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44317732
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44041936
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.43031182
73AR_21909140_ChIP-Seq_LNCAP_Human1.42106205
74SPI1_23127762_ChIP-Seq_K562_Human1.41464117
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41308029
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41304981
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41148419
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40564693
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.40514418
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37838236
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37611739
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37377522
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36607991
84* TCF7_22412390_ChIP-Seq_EML_Mouse1.36594231
85* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36271325
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35032011
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34123747
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32717213
89KDM5A_27292631_Chip-Seq_BREAST_Human1.32405728
90SCL_19346495_ChIP-Seq_HPC-7_Human1.30518035
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29810851
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29267782
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.28669233
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.28504789
95* TTF2_22483619_ChIP-Seq_HELA_Human1.27587152
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26849951
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.26368170
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26217822
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25719137
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25586344
101* CTCF_26484167_Chip-Seq_Bcells_Mouse1.25289938
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24923137
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22355008
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21578239
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21491615
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19703032
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18994904
108* PHF8_20622854_ChIP-Seq_HELA_Human1.18530211
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18215549
110MYB_26560356_Chip-Seq_TH2_Human1.18170796
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.17698406
112* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15898433
113* SPI1_23547873_ChIP-Seq_NB4_Human1.15887747
114* NCOR1_26117541_ChIP-Seq_K562_Human1.15329629
115* E2F1_20622854_ChIP-Seq_HELA_Human1.14688626
116CTCF_21964334_Chip-Seq_Bcells_Human1.13889721
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13605548
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11068455
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10858126
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10830086
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10696786
122RACK7_27058665_Chip-Seq_MCF-7_Human1.10396681
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.10372515
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10304014
125MYB_26560356_Chip-Seq_TH1_Human1.10180619
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09099377
127TFEB_21752829_ChIP-Seq_HELA_Human1.08781305
128* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08333646
129YY1_22570637_ChIP-Seq_MALME-3M_Human1.08172286
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08143615
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06737918
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05530533
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04873369
134* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04709989
135* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04573207
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03385263
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02202661
138LXR_22158963_ChIP-Seq_LIVER_Mouse1.01863861
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00026163
140ELK1_19687146_ChIP-ChIP_HELA_Human0.98601130
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96952250
142GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96539263
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96102779
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95875311
145* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95608418
146* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94839771
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94237646
148VDR_21846776_ChIP-Seq_THP-1_Human0.93230591
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91398385
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91009741
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90170895
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88059892
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86547981
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84045164
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83253062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11114945
2MP0005365_abnormal_bile_salt3.44640574
3MP0002139_abnormal_hepatobiliary_system3.33822045
4MP0009840_abnormal_foam_cell3.33053492
5MP0003303_peritoneal_inflammation3.32754130
6MP0005360_urolithiasis2.69817857
7MP0009278_abnormal_bone_marrow2.69423431
8MP0005085_abnormal_gallbladder_physiolo2.55999317
9MP0003172_abnormal_lysosome_physiology2.48110135
10MP0003806_abnormal_nucleotide_metabolis2.40127276
11MP0003111_abnormal_nucleus_morphology2.36339997
12MP0001666_abnormal_nutrient_absorption2.25776311
13MP0004957_abnormal_blastocyst_morpholog2.09680730
14MP0003191_abnormal_cellular_cholesterol2.05978885
15MP0003718_maternal_effect1.94927649
16MP0009333_abnormal_splenocyte_physiolog1.94708510
17MP0010094_abnormal_chromosome_stability1.92956229
18MP0003077_abnormal_cell_cycle1.92000652
19MP0008875_abnormal_xenobiotic_pharmacok1.91023708
20MP0003183_abnormal_peptide_metabolism1.89721007
21MP0002132_abnormal_respiratory_system1.88612600
22MP0009764_decreased_sensitivity_to1.85220651
23MP0001533_abnormal_skeleton_physiology1.82146204
24MP0005451_abnormal_body_composition1.79626555
25MP0004019_abnormal_vitamin_homeostasis1.79375951
26MP0008058_abnormal_DNA_repair1.78596988
27MP0005220_abnormal_exocrine_pancreas1.76470534
28MP0002653_abnormal_ependyma_morphology1.74174958
29MP0000490_abnormal_crypts_of1.73142330
30MP0008007_abnormal_cellular_replicative1.71202573
31MP0003252_abnormal_bile_duct1.70269115
32MP0010329_abnormal_lipoprotein_level1.65759888
33MP0001835_abnormal_antigen_presentation1.63683519
34MP0005083_abnormal_biliary_tract1.62653068
35MP0000465_gastrointestinal_hemorrhage1.61480623
36MP0002396_abnormal_hematopoietic_system1.56563071
37MP0003186_abnormal_redox_activity1.52262458
38MP0005332_abnormal_amino_acid1.50503019
39MP0001764_abnormal_homeostasis1.47799283
40MP0000609_abnormal_liver_physiology1.46269446
41MP0003866_abnormal_defecation1.44547813
42MP0005084_abnormal_gallbladder_morpholo1.44255270
43MP0003300_gastrointestinal_ulcer1.43503932
44MP0005671_abnormal_response_to1.43388608
45MP0003763_abnormal_thymus_physiology1.41718769
46MP0003436_decreased_susceptibility_to1.40918823
47MP0005058_abnormal_lysosome_morphology1.39868537
48MP0003724_increased_susceptibility_to1.34944366
49MP0002822_catalepsy1.31351320
50MP0005319_abnormal_enzyme/_coenzyme1.30301002
51MP0009643_abnormal_urine_homeostasis1.29147424
52MP0004264_abnormal_extraembryonic_tissu1.28760123
53MP0009785_altered_susceptibility_to1.27775082
54MP0008260_abnormal_autophagy1.26104513
55MP0000685_abnormal_immune_system1.23472199
56MP0003075_altered_response_to1.23404271
57MP0006082_CNS_inflammation1.19484048
58MP0008469_abnormal_protein_level1.18786969
59MP0001853_heart_inflammation1.16758775
60MP0001800_abnormal_humoral_immune1.16255614
61MP0000689_abnormal_spleen_morphology1.16098796
62MP0000343_altered_response_to1.16021433
63MP0004510_myositis1.15514806
64MP0002138_abnormal_hepatobiliary_system1.14207847
65MP0005464_abnormal_platelet_physiology1.13894455
66MP0002398_abnormal_bone_marrow1.13824911
67MP0000598_abnormal_liver_morphology1.13567973
68MP0002722_abnormal_immune_system1.13495085
69MP0005025_abnormal_response_to1.10845875
70MP0003786_premature_aging1.10399241
71MP0001845_abnormal_inflammatory_respons1.07896747
72MP0003195_calcinosis1.07787557
73MP0002277_abnormal_respiratory_mucosa1.07654031
74MP0000858_altered_metastatic_potential1.07141270
75MP0002723_abnormal_immune_serum1.06893808
76MP0005075_abnormal_melanosome_morpholog1.06111768
77MP0010155_abnormal_intestine_physiology1.05008569
78MP0002452_abnormal_antigen_presenting1.04891703
79MP0005000_abnormal_immune_tolerance1.03593889
80MP0001819_abnormal_immune_cell1.03064999
81MP0002420_abnormal_adaptive_immunity1.02756129
82MP0004808_abnormal_hematopoietic_stem1.02746742
83MP0009765_abnormal_xenobiotic_induced1.02724854
84MP0006054_spinal_hemorrhage1.02160683
85MP0002148_abnormal_hypersensitivity_rea1.02108304
86MP0002429_abnormal_blood_cell1.01452100
87MP0000716_abnormal_immune_system0.99903706
88MP0000604_amyloidosis0.99410241
89MP0002419_abnormal_innate_immunity0.98133794
90MP0001727_abnormal_embryo_implantation0.97299044
91MP0010307_abnormal_tumor_latency0.96979216
92MP0006035_abnormal_mitochondrial_morpho0.96805472
93MP0002019_abnormal_tumor_incidence0.96771373
94MP0008057_abnormal_DNA_replication0.96703948
95MP0001730_embryonic_growth_arrest0.94296549
96MP0003868_abnormal_feces_composition0.93631365
97MP0005397_hematopoietic_system_phenotyp0.93613736
98MP0001545_abnormal_hematopoietic_system0.93613736
99MP0005410_abnormal_fertilization0.91532748
100MP0001756_abnormal_urination0.90099115
101MP0005636_abnormal_mineral_homeostasis0.89685092
102MP0001663_abnormal_digestive_system0.89541180
103MP0001873_stomach_inflammation0.89043870
104MP0009763_increased_sensitivity_to0.88716682
105MP0003828_pulmonary_edema0.86251887
106MP0003878_abnormal_ear_physiology0.85851750
107MP0005377_hearing/vestibular/ear_phenot0.85851750
108MP0000703_abnormal_thymus_morphology0.85851521
109MP0006036_abnormal_mitochondrial_physio0.85746166
110MP0002118_abnormal_lipid_homeostasis0.85316133
111MP0002405_respiratory_system_inflammati0.85201127
112MP0008932_abnormal_embryonic_tissue0.84218681
113MP0003656_abnormal_erythrocyte_physiolo0.83550830
114MP0002693_abnormal_pancreas_physiology0.83358442
115MP0000313_abnormal_cell_death0.82946118
116MP0005310_abnormal_salivary_gland0.80743778
117MP0005395_other_phenotype0.80712948
118MP0000350_abnormal_cell_proliferation0.80473319
119MP0002998_abnormal_bone_remodeling0.80137240
120MP0002136_abnormal_kidney_physiology0.79731487
121MP0005387_immune_system_phenotype0.79518679
122MP0001790_abnormal_immune_system0.79518679
123MP0004947_skin_inflammation0.79384525
124MP0001661_extended_life_span0.77376891
125MP0001986_abnormal_taste_sensitivity0.76664858
126MP0000358_abnormal_cell_content/0.76236801
127MP0001944_abnormal_pancreas_morphology0.76055072
128MP0005390_skeleton_phenotype0.73511139
129MP0000678_abnormal_parathyroid_gland0.72747450
130MP0008874_decreased_physiological_sensi0.70362831
131MP0005166_decreased_susceptibility_to0.67993187
132MP0004381_abnormal_hair_follicle0.67663123
133MP0005584_abnormal_enzyme/coenzyme_acti0.67024796
134MP0000681_abnormal_thyroid_gland0.65091523
135MP0001849_ear_inflammation0.64173298
136MP0003329_amyloid_beta_deposits0.63972839
137MP0001851_eye_inflammation0.63032905
138MP0003221_abnormal_cardiomyocyte_apopto0.60238034
139MP0003448_altered_tumor_morphology0.59708100

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.85612221
2Abnormality of glycolipid metabolism (HP:0010969)4.67876204
3Abnormality of liposaccharide metabolism (HP:0010968)4.67876204
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.67876204
5Recurrent bacterial skin infections (HP:0005406)4.67176845
6Abnormality of macrophages (HP:0004311)4.65781033
7Obstructive lung disease (HP:0006536)4.51771328
8Chronic obstructive pulmonary disease (HP:0006510)4.51771328
9Eczematoid dermatitis (HP:0000976)4.43094812
10Elevated erythrocyte sedimentation rate (HP:0003565)4.16774919
11Myositis (HP:0100614)3.76284487
12Mediastinal lymphadenopathy (HP:0100721)3.73295675
13Hyperglycinemia (HP:0002154)3.66390535
14Hyperglycinuria (HP:0003108)3.59900411
15Birth length less than 3rd percentile (HP:0003561)3.48759192
16Increased IgM level (HP:0003496)3.39926574
17Stomatitis (HP:0010280)3.39136531
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32580057
19Increased cerebral lipofuscin (HP:0011813)3.31592143
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.23786979
21Meningitis (HP:0001287)3.16827618
22Recurrent fungal infections (HP:0002841)3.14211685
23Breast hypoplasia (HP:0003187)3.05232430
24Reduced antithrombin III activity (HP:0001976)3.00286721
25Microretrognathia (HP:0000308)3.00212270
26Orchitis (HP:0100796)2.98461980
27Purpura (HP:0000979)2.92210783
28Recurrent skin infections (HP:0001581)2.92130267
29Urticaria (HP:0001025)2.90695080
30Abnormality of serine family amino acid metabolism (HP:0010894)2.87127325
31Abnormality of glycine metabolism (HP:0010895)2.87127325
32Dysostosis multiplex (HP:0000943)2.86358166
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.84241433
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.84006860
35Hypobetalipoproteinemia (HP:0003563)2.82605214
36Increased IgE level (HP:0003212)2.81869797
37Increased serum ferritin (HP:0003281)2.80850184
38Loss of speech (HP:0002371)2.79599645
39Hypertensive crisis (HP:0100735)2.75805663
40Vacuolated lymphocytes (HP:0001922)2.75184998
41Gout (HP:0001997)2.73905846
42Recurrent viral infections (HP:0004429)2.70680900
43Abnormality of pyrimidine metabolism (HP:0004353)2.70533309
44Abnormality of serum amino acid levels (HP:0003112)2.68704041
45Hepatosplenomegaly (HP:0001433)2.64170684
46Chronic mucocutaneous candidiasis (HP:0002728)2.62514674
47Recurrent cutaneous fungal infections (HP:0011370)2.62514674
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58057246
49Abnormality of alanine metabolism (HP:0010916)2.58057246
50Hyperalaninemia (HP:0003348)2.58057246
51Cellulitis (HP:0100658)2.57004915
52Hypergammaglobulinemia (HP:0010702)2.56151224
53Retrobulbar optic neuritis (HP:0100654)2.55992177
54Optic neuritis (HP:0100653)2.55992177
55Progressive neurologic deterioration (HP:0002344)2.55657017
56Aplastic anemia (HP:0001915)2.53385538
57Abnormality of iron homeostasis (HP:0011031)2.50988281
58Oral leukoplakia (HP:0002745)2.50462798
59Abnormality of lateral ventricle (HP:0030047)2.49534109
60IgM deficiency (HP:0002850)2.48908138
61Cerebral palsy (HP:0100021)2.48748477
62Type I transferrin isoform profile (HP:0003642)2.47286789
63Prolonged partial thromboplastin time (HP:0003645)2.46945973
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.45682364
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42684252
66Abnormality of polysaccharide metabolism (HP:0011012)2.42684252
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42684252
68Panhypogammaglobulinemia (HP:0003139)2.40793472
69Abnormality of the anterior horn cell (HP:0006802)2.38809794
70Degeneration of anterior horn cells (HP:0002398)2.38809794
71Rough bone trabeculation (HP:0100670)2.38176044
72Abnormality of fatty-acid metabolism (HP:0004359)2.37504763
73Gastrointestinal infarctions (HP:0005244)2.37381087
74Abnormal protein glycosylation (HP:0012346)2.37224841
75Abnormal glycosylation (HP:0012345)2.37224841
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37224841
77Abnormal protein N-linked glycosylation (HP:0012347)2.37224841
78Abnormality of the intrinsic pathway (HP:0010989)2.36455591
79Generalized aminoaciduria (HP:0002909)2.35416653
80Gingivitis (HP:0000230)2.32645774
81Petechiae (HP:0000967)2.32034556
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.31223649
83Pustule (HP:0200039)2.29631979
84Xanthomatosis (HP:0000991)2.29394744
85Abnormality of T cell physiology (HP:0011840)2.27871052
86Prolonged bleeding time (HP:0003010)2.27824907
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.26944249
88Hyperlipoproteinemia (HP:0010980)2.26762698
89Ragged-red muscle fibers (HP:0003200)2.26727423
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25116104
91Hyperammonemia (HP:0001987)2.24016731
92Intrahepatic cholestasis (HP:0001406)2.23902000
93Vasculitis (HP:0002633)2.23387580
94Carpal bone hypoplasia (HP:0001498)2.23142245
95Agammaglobulinemia (HP:0004432)2.21626948
96Hypoglycemic coma (HP:0001325)2.21626340
97Urinary glycosaminoglycan excretion (HP:0003541)2.21392624
98Mucopolysacchariduria (HP:0008155)2.21392624
99Mutism (HP:0002300)2.19990017
100Gastrointestinal inflammation (HP:0004386)2.19689866
101Dicarboxylic aciduria (HP:0003215)2.16788511
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16788511
103Megaloblastic anemia (HP:0001889)2.15866240
104Increased muscle lipid content (HP:0009058)2.15810608
105Aplasia/Hypoplasia of the thymus (HP:0010515)2.13755219
106Fat malabsorption (HP:0002630)2.10044675
107Abnormality of transition element cation homeostasis (HP:0011030)2.08765972
108Chest pain (HP:0100749)2.08453625
109Epistaxis (HP:0000421)2.08283992
110Abnormality of nucleobase metabolism (HP:0010932)2.07322853
111Thrombocytosis (HP:0001894)2.05856492
112Systemic lupus erythematosus (HP:0002725)2.05038458
113Skin rash (HP:0000988)2.04830698
114Leukocytosis (HP:0001974)2.03233098
115Deep venous thrombosis (HP:0002625)2.02913494
116Amyloidosis (HP:0011034)2.02861761
117Inflammation of the large intestine (HP:0002037)2.02623128
118Nonimmune hydrops fetalis (HP:0001790)1.98273606
119Lymphopenia (HP:0001888)1.97763681
120Reticulocytopenia (HP:0001896)1.97510086
121Patellar aplasia (HP:0006443)1.97121784
122Steatorrhea (HP:0002570)1.96963623
123Upper motor neuron abnormality (HP:0002127)1.96498627
124Biconcave vertebral bodies (HP:0004586)1.93779032
125Sepsis (HP:0100806)1.93466791
126Abnormal gallbladder physiology (HP:0012438)1.93118968
127Cholecystitis (HP:0001082)1.93118968
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93050071
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93050071
130Pancytopenia (HP:0001876)1.92914779
131Vertebral compression fractures (HP:0002953)1.92755701
132Death in infancy (HP:0001522)1.92567809
133Nausea (HP:0002018)1.92136767
134Abnormality of the common coagulation pathway (HP:0010990)1.91955141
135Posterior subcapsular cataract (HP:0007787)1.91518190
136Lethargy (HP:0001254)1.90763933
137Complement deficiency (HP:0004431)1.90403890
138Anorexia (HP:0002039)1.89880444
139Colitis (HP:0002583)1.89781322
140Seborrheic dermatitis (HP:0001051)1.88559680
141Aplasia/Hypoplasia of the patella (HP:0006498)1.88492305
142Abnormality of T cells (HP:0002843)1.88427580
143Spontaneous hematomas (HP:0007420)1.88407311
144Severe visual impairment (HP:0001141)1.86942725
145Recurrent gram-negative bacterial infections (HP:0005420)1.86908339
1463-Methylglutaconic aciduria (HP:0003535)1.85425078
147Brushfield spots (HP:0001088)1.85411341
148Hypolipoproteinemia (HP:0010981)1.85252347
149Abnormal spermatogenesis (HP:0008669)1.84841802
150Bone marrow hypocellularity (HP:0005528)1.83869280
151Abnormality of the prostate (HP:0008775)1.83482085
152Interstitial pulmonary disease (HP:0006530)1.83433400
153Joint hemorrhage (HP:0005261)1.83260771
154Episodic fever (HP:0001954)1.82792174
155Pulmonary infiltrates (HP:0002113)1.82360586
156Neuronal loss in central nervous system (HP:0002529)1.82102820
157Hemoptysis (HP:0002105)1.82064123
158Prolonged neonatal jaundice (HP:0006579)1.81867440
159Progressive muscle weakness (HP:0003323)1.81636633
160Abnormality of the pleura (HP:0002103)1.81458203
161Impulsivity (HP:0100710)1.81121139
162Recurrent pneumonia (HP:0006532)1.79787334
163Glomerulonephritis (HP:0000099)1.79685122
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78604712
165Splenomegaly (HP:0001744)1.77647004
166IgG deficiency (HP:0004315)1.77187075
167Ketosis (HP:0001946)1.76560689
168Abnormality of purine metabolism (HP:0004352)1.75717624
169Conjugated hyperbilirubinemia (HP:0002908)1.74737210
170Abnormal trabecular bone morphology (HP:0100671)1.74263650
171Combined immunodeficiency (HP:0005387)1.71576659
172Multiple enchondromatosis (HP:0005701)1.67965213
173Entropion (HP:0000621)1.67477204
174Sparse eyelashes (HP:0000653)1.66145564
175Neutropenia (HP:0001875)1.65818455
176Granulocytopenia (HP:0001913)1.65368438
177Abnormal number of erythroid precursors (HP:0012131)1.64829759
178Myocardial infarction (HP:0001658)1.64570324
179Poor head control (HP:0002421)1.64458483
180Encephalitis (HP:0002383)1.63948133
181Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63274968
182Periodontitis (HP:0000704)1.63205416
183Severe combined immunodeficiency (HP:0004430)1.62812490
184Autoimmune thrombocytopenia (HP:0001973)1.62170042
185Abnormality of methionine metabolism (HP:0010901)1.61861623
186Increased serum lactate (HP:0002151)1.59924344
187Hyperbilirubinemia (HP:0002904)1.58861623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.11355237
2BCKDK3.65102886
3MAP3K113.14643009
4NME23.06310637
5RIPK42.95760142
6STK162.92086420
7WEE12.77953420
8IRAK32.39192294
9TAOK32.37580554
10EIF2AK12.26606062
11ERN12.25316098
12TESK12.25016547
13PLK42.09489753
14EIF2AK32.09323014
15NEK22.08203814
16EPHA22.01722690
17TNK22.00030491
18MAP4K11.91754644
19PRPF4B1.86792188
20PASK1.84207689
21ZAP701.82164254
22FES1.80460063
23BRAF1.74039010
24CDK191.73927014
25TSSK61.62283555
26KDR1.61225738
27AKT31.59426136
28BRSK21.57423229
29FLT31.56482258
30TAOK11.54443215
31MAP2K21.54389795
32PIM21.52861662
33SRPK11.51500273
34MAP2K31.48592933
35SMG11.45339556
36RPS6KA41.42732909
37CSK1.42229079
38BTK1.37803953
39TYK21.36143754
40VRK21.31564606
41TXK1.30586777
42TESK21.28471315
43TEC1.27552701
44SIK31.27339027
45IRAK41.23209286
46BLK1.23185373
47DYRK31.21044669
48CDK71.18929107
49DYRK1B1.18124350
50ZAK1.15969870
51CCNB11.14596448
52PLK11.14271024
53ACVR1B1.13236131
54MAP3K11.10542361
55TTK1.08435655
56FGFR41.07629873
57AURKB1.06598784
58MATK1.03287557
59SIK21.02528961
60CDK40.99044815
61MAP3K130.98580112
62HCK0.96952573
63MAP4K20.93650989
64VRK10.92470503
65TBK10.92037220
66NME10.91419296
67MAP3K140.90627154
68EPHB10.89685865
69PAK40.89386841
70JAK30.88437303
71KSR20.87396058
72PKN20.85605235
73FGR0.84852851
74MARK20.84072377
75MKNK10.82853816
76TAOK20.82825560
77STK38L0.82789775
78IRAK20.82522770
79EIF2AK20.82361195
80LRRK20.81574954
81BRSK10.80537895
82ATR0.80366923
83MAP3K80.79963062
84PLK30.79301084
85PIM10.78926987
86MAP3K120.78208040
87PRKCI0.76119107
88MAPK110.75545781
89JAK20.75375775
90LCK0.74895852
91IKBKB0.74376766
92ITK0.74009576
93KIT0.72928616
94RPS6KB20.72503134
95SCYL20.71391715
96PRKD20.70710807
97CHUK0.69762247
98MARK30.69751783
99RAF10.67271234
100CDC70.66193552
101CDK80.64674670
102MAP2K60.63849126
103AURKA0.61970695
104IKBKE0.61254538
105MAP3K100.60844133
106MKNK20.60627102
107DAPK10.60436387
108INSRR0.60314839
109MAP3K30.59554348
110CDK30.59549383
111MAP2K70.59376835
112ARAF0.59194490
113NLK0.58339257
114SIK10.58172385
115GRK60.57205120
116MAP2K40.57071323
117STK100.57019741
118SYK0.54762246
119CHEK20.53382084
120IRAK10.53207080
121WNK30.52753692
122TIE10.52557712
123LYN0.50746301
124EEF2K0.50181999
125MAP3K50.49576328
126RPS6KL10.49176085
127RPS6KC10.49176085
128TLK10.48183334
129TRIB30.47746982
130TGFBR10.47129896
131RPS6KA50.47044419
132NEK90.46938396
133ABL20.46251734
134PAK10.42611190
135CSNK2A10.41570974
136PINK10.41295443
137PIK3CG0.41079245
138PRKCQ0.40911927
139PDPK10.40798634
140CAMK40.40331186
141PDK10.38829495
142CSF1R0.38560685
143PTK60.37964375
144GRK70.37928313
145DYRK20.37085571
146LIMK10.36423552
147MOS0.35264967
148RPS6KA60.35095941
149RPS6KA20.34795196
150MAP3K60.33170058
151BMX0.30486907
152FYN0.30296185

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.91592086
2Allograft rejection_Homo sapiens_hsa053302.79869899
3DNA replication_Homo sapiens_hsa030302.70757139
4RNA polymerase_Homo sapiens_hsa030202.61700104
5Folate biosynthesis_Homo sapiens_hsa007902.56989393
6Graft-versus-host disease_Homo sapiens_hsa053322.55370740
7Autoimmune thyroid disease_Homo sapiens_hsa053202.51070078
8Asthma_Homo sapiens_hsa053102.50092201
9Proteasome_Homo sapiens_hsa030502.37216024
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32055946
11Osteoclast differentiation_Homo sapiens_hsa043802.31175964
12Pyrimidine metabolism_Homo sapiens_hsa002402.23911208
13Mismatch repair_Homo sapiens_hsa034302.14272978
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.13403948
15Base excision repair_Homo sapiens_hsa034102.05535512
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02988453
17One carbon pool by folate_Homo sapiens_hsa006701.99354339
18Sulfur relay system_Homo sapiens_hsa041221.93410877
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.92501711
20Type I diabetes mellitus_Homo sapiens_hsa049401.90268315
21Tuberculosis_Homo sapiens_hsa051521.89705279
22Ribosome_Homo sapiens_hsa030101.89345203
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86936419
24Protein export_Homo sapiens_hsa030601.86879361
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79028818
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.74255021
27Viral myocarditis_Homo sapiens_hsa054161.70767361
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68136850
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67326564
30Phagosome_Homo sapiens_hsa041451.66480819
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65905541
32Rheumatoid arthritis_Homo sapiens_hsa053231.64309328
33RNA transport_Homo sapiens_hsa030131.61965728
34Selenocompound metabolism_Homo sapiens_hsa004501.61826606
35Acute myeloid leukemia_Homo sapiens_hsa052211.60181170
36Pentose phosphate pathway_Homo sapiens_hsa000301.59296264
37B cell receptor signaling pathway_Homo sapiens_hsa046621.57501450
38Homologous recombination_Homo sapiens_hsa034401.51258260
39Shigellosis_Homo sapiens_hsa051311.51097586
40Vitamin digestion and absorption_Homo sapiens_hsa049771.49440259
41Spliceosome_Homo sapiens_hsa030401.47755511
42Hematopoietic cell lineage_Homo sapiens_hsa046401.47346364
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43030168
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41536010
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40953703
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39554494
47Nucleotide excision repair_Homo sapiens_hsa034201.38933394
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38161669
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.36123960
50Cell cycle_Homo sapiens_hsa041101.36055610
51Salmonella infection_Homo sapiens_hsa051321.33615936
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32475117
53Biosynthesis of amino acids_Homo sapiens_hsa012301.25687590
54p53 signaling pathway_Homo sapiens_hsa041151.25418114
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23050747
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22113839
57Malaria_Homo sapiens_hsa051441.21248781
58Staphylococcus aureus infection_Homo sapiens_hsa051501.16124590
59Fat digestion and absorption_Homo sapiens_hsa049751.15623276
60Purine metabolism_Homo sapiens_hsa002301.15224674
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15136256
62Toxoplasmosis_Homo sapiens_hsa051451.12566823
63Other glycan degradation_Homo sapiens_hsa005111.12017376
64Complement and coagulation cascades_Homo sapiens_hsa046101.09153237
65Peroxisome_Homo sapiens_hsa041461.08299437
66Collecting duct acid secretion_Homo sapiens_hsa049661.07799606
67Galactose metabolism_Homo sapiens_hsa000521.07683534
68Fructose and mannose metabolism_Homo sapiens_hsa000511.07024609
69Oxidative phosphorylation_Homo sapiens_hsa001901.06677295
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03862879
71Regulation of autophagy_Homo sapiens_hsa041401.03565701
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01390419
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00647905
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98280004
75Tryptophan metabolism_Homo sapiens_hsa003800.96378050
76Pertussis_Homo sapiens_hsa051330.96197787
77Chemokine signaling pathway_Homo sapiens_hsa040620.95613414
78Caffeine metabolism_Homo sapiens_hsa002320.95335038
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94669938
80T cell receptor signaling pathway_Homo sapiens_hsa046600.94016291
81Fatty acid degradation_Homo sapiens_hsa000710.93072829
82Antigen processing and presentation_Homo sapiens_hsa046120.92895524
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.92030930
84Basal transcription factors_Homo sapiens_hsa030220.91777593
85Non-homologous end-joining_Homo sapiens_hsa034500.91291513
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91129656
87N-Glycan biosynthesis_Homo sapiens_hsa005100.90963625
88Primary immunodeficiency_Homo sapiens_hsa053400.90805336
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90756627
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90085851
91Parkinsons disease_Homo sapiens_hsa050120.87074561
92Carbon metabolism_Homo sapiens_hsa012000.86731273
93Legionellosis_Homo sapiens_hsa051340.85734653
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84253028
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.83615910
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83148572
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82649783
98Hepatitis B_Homo sapiens_hsa051610.81298968
99Notch signaling pathway_Homo sapiens_hsa043300.80637069
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80378462
101Fanconi anemia pathway_Homo sapiens_hsa034600.79546831
102beta-Alanine metabolism_Homo sapiens_hsa004100.78627923
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78568094
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78056748
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77987507
106Arginine and proline metabolism_Homo sapiens_hsa003300.75308174
107Lysosome_Homo sapiens_hsa041420.74259945
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74039052
109Sulfur metabolism_Homo sapiens_hsa009200.73185092
110Herpes simplex infection_Homo sapiens_hsa051680.73136397
111Endocytosis_Homo sapiens_hsa041440.72693988
112Chemical carcinogenesis_Homo sapiens_hsa052040.71703347
113Glutathione metabolism_Homo sapiens_hsa004800.71350411
114Retinol metabolism_Homo sapiens_hsa008300.71256181
115Vibrio cholerae infection_Homo sapiens_hsa051100.69717288
116Epstein-Barr virus infection_Homo sapiens_hsa051690.67611159
117RNA degradation_Homo sapiens_hsa030180.66315901
118Viral carcinogenesis_Homo sapiens_hsa052030.65470773
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65365428
120Non-small cell lung cancer_Homo sapiens_hsa052230.64508797
121TNF signaling pathway_Homo sapiens_hsa046680.64361656
122Metabolic pathways_Homo sapiens_hsa011000.64040400
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.63527846
124Systemic lupus erythematosus_Homo sapiens_hsa053220.63235711
125VEGF signaling pathway_Homo sapiens_hsa043700.62593900
126Hepatitis C_Homo sapiens_hsa051600.61955381
127Arginine biosynthesis_Homo sapiens_hsa002200.61877527
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61551540
129Glycerolipid metabolism_Homo sapiens_hsa005610.60203311
130HTLV-I infection_Homo sapiens_hsa051660.59239001
131Histidine metabolism_Homo sapiens_hsa003400.58455790
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.57852424
133Bladder cancer_Homo sapiens_hsa052190.57833727
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.57330249
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57052311
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54592943
137Fatty acid elongation_Homo sapiens_hsa000620.52655589
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.51459853
139Starch and sucrose metabolism_Homo sapiens_hsa005000.51309592
140Pancreatic cancer_Homo sapiens_hsa052120.51246371
141Measles_Homo sapiens_hsa051620.50981069
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49024484
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.48368282
144Huntingtons disease_Homo sapiens_hsa050160.47275365
145Phenylalanine metabolism_Homo sapiens_hsa003600.47203755
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43184877
147Chronic myeloid leukemia_Homo sapiens_hsa052200.42658041
148Arachidonic acid metabolism_Homo sapiens_hsa005900.42382046
149African trypanosomiasis_Homo sapiens_hsa051430.40875700
150Synaptic vesicle cycle_Homo sapiens_hsa047210.40796043
151Butanoate metabolism_Homo sapiens_hsa006500.40668979
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.38660196
153PPAR signaling pathway_Homo sapiens_hsa033200.37974850
154Renin-angiotensin system_Homo sapiens_hsa046140.37673616
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.37427862
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36841390
157Apoptosis_Homo sapiens_hsa042100.35221313
158ABC transporters_Homo sapiens_hsa020100.34954921
159Influenza A_Homo sapiens_hsa051640.34788884
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34326068
161Platelet activation_Homo sapiens_hsa046110.33994536
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33436154
163Leishmaniasis_Homo sapiens_hsa051400.32673911
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32492491
165Propanoate metabolism_Homo sapiens_hsa006400.31312085

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »