TOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)5.58673337
2negative thymic T cell selection (GO:0045060)5.35758635
3positive T cell selection (GO:0043368)4.96342570
4regulation of isotype switching to IgG isotypes (GO:0048302)4.80606043
5positive regulation of gamma-delta T cell activation (GO:0046645)4.75583596
6presynaptic membrane assembly (GO:0097105)4.65146776
7cellular response to interleukin-15 (GO:0071350)4.64782198
8gamma-aminobutyric acid transport (GO:0015812)4.56137786
9nucleobase catabolic process (GO:0046113)4.45292347
10inositol phosphate catabolic process (GO:0071545)4.30335999
11postsynaptic membrane organization (GO:0001941)4.30237244
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22748700
13presynaptic membrane organization (GO:0097090)4.15581782
14phosphorylated carbohydrate dephosphorylation (GO:0046838)4.15155556
15inositol phosphate dephosphorylation (GO:0046855)4.15155556
16T cell selection (GO:0045058)4.06776446
17positive thymic T cell selection (GO:0045059)4.02147615
18response to interleukin-15 (GO:0070672)4.01297456
19thymic T cell selection (GO:0045061)3.88367560
20T cell receptor signaling pathway (GO:0050852)3.87175200
21neuron cell-cell adhesion (GO:0007158)3.82547838
22interferon-gamma production (GO:0032609)3.75429945
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71608897
24behavioral response to nicotine (GO:0035095)3.67737826
25regulation of T cell tolerance induction (GO:0002664)3.67190528
26leukocyte aggregation (GO:0070486)3.61656974
27negative regulation of osteoblast proliferation (GO:0033689)3.57164882
28retinal cone cell development (GO:0046549)3.54856473
29startle response (GO:0001964)3.51845796
30viral protein processing (GO:0019082)3.50064388
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48605435
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.48554686
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48227970
34activated T cell proliferation (GO:0050798)3.39788185
35neural tube formation (GO:0001841)3.39687158
36nonmotile primary cilium assembly (GO:0035058)3.39625461
37positive regulation of mitochondrial fission (GO:0090141)3.38641310
38lymphocyte costimulation (GO:0031294)3.36166284
39intraciliary transport (GO:0042073)3.35824925
40T cell costimulation (GO:0031295)3.34555453
41antigen receptor-mediated signaling pathway (GO:0050851)3.34530814
42protein polyglutamylation (GO:0018095)3.33770019
43positive regulation of protein homodimerization activity (GO:0090073)3.33030551
44positive regulation of uterine smooth muscle contraction (GO:0070474)3.25249641
45positive regulation of amino acid transport (GO:0051957)3.22125507
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19412767
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18742457
48regulation of T cell receptor signaling pathway (GO:0050856)3.18236442
49establishment of mitochondrion localization (GO:0051654)3.17446633
50tolerance induction (GO:0002507)3.16438257
51positive regulation of interleukin-8 secretion (GO:2000484)3.15524690
52sequestering of actin monomers (GO:0042989)3.14099415
53epithelial cilium movement (GO:0003351)3.13951146
54regulation of gamma-delta T cell activation (GO:0046643)3.11309677
55negative regulation of cell killing (GO:0031342)3.10134650
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10134650
57negative regulation of telomere maintenance (GO:0032205)3.08471488
58regulation of respiratory system process (GO:0044065)3.07923631
59forebrain neuron differentiation (GO:0021879)3.06146188
60L-fucose catabolic process (GO:0042355)3.04094824
61fucose catabolic process (GO:0019317)3.04094824
62L-fucose metabolic process (GO:0042354)3.04094824
63mechanosensory behavior (GO:0007638)3.02991535
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02900842
65T cell differentiation (GO:0030217)3.02844707
66regulation of alpha-beta T cell proliferation (GO:0046640)3.02800048
67DNA deamination (GO:0045006)3.02049505
68regulation of cilium movement (GO:0003352)3.00846940
69negative regulation of oligodendrocyte differentiation (GO:0048715)3.00459519
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00094267
71cell differentiation involved in metanephros development (GO:0072202)2.99883754
72glycosphingolipid biosynthetic process (GO:0006688)2.99158202
73cilium morphogenesis (GO:0060271)2.98608786
74regulation of interleukin-2 biosynthetic process (GO:0045076)2.98583485
75synaptic vesicle docking involved in exocytosis (GO:0016081)2.98116929
76regulation of defense response to virus by virus (GO:0050690)2.97474615
77pyrimidine nucleobase catabolic process (GO:0006208)2.95312473
78regulation of regulatory T cell differentiation (GO:0045589)2.94775747
79T cell migration (GO:0072678)2.94038644
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93298521
81axonal fasciculation (GO:0007413)2.92804707
82lymphoid progenitor cell differentiation (GO:0002320)2.92637848
83regulation of pigment cell differentiation (GO:0050932)2.91338621
84regulation of development, heterochronic (GO:0040034)2.90538263
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90459284
86kidney morphogenesis (GO:0060993)2.89571289
87alpha-beta T cell differentiation (GO:0046632)2.89432764
88cellular ketone body metabolic process (GO:0046950)2.88891790
89synaptic transmission, glutamatergic (GO:0035249)2.88791334
90neuronal action potential propagation (GO:0019227)2.87021964
91dendritic spine morphogenesis (GO:0060997)2.86104102
92regulation of B cell receptor signaling pathway (GO:0050855)2.84767451
93regulation of glutamate receptor signaling pathway (GO:1900449)2.83772572
94axoneme assembly (GO:0035082)2.83075660
95T cell homeostasis (GO:0043029)2.82378082
96calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81725940
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81195431
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79376008
99regulation of gamma-delta T cell differentiation (GO:0045586)2.78537207
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78382072
101positive regulation of granulocyte differentiation (GO:0030854)2.77910515
102regulation of action potential (GO:0098900)2.76948883
103synapse assembly (GO:0007416)2.76865375
104positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74810224
105retinal ganglion cell axon guidance (GO:0031290)2.74680052
106developmental pigmentation (GO:0048066)2.74362506
107T cell lineage commitment (GO:0002360)2.73739213
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.73044585
109T-helper cell differentiation (GO:0042093)2.73044585
110cilium organization (GO:0044782)2.72031256
111histone H2A acetylation (GO:0043968)2.71945121
112cilium assembly (GO:0042384)2.69354329
113protein-cofactor linkage (GO:0018065)2.69050429
114regulation of telomere maintenance (GO:0032204)2.68993578
115serotonin receptor signaling pathway (GO:0007210)2.68562833
116negative regulation of mast cell activation (GO:0033004)2.67945215
117regulation of timing of cell differentiation (GO:0048505)2.67327077
118glutamate receptor signaling pathway (GO:0007215)2.65913211
119protein localization to cilium (GO:0061512)2.65737563
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65706464
121neuronal action potential (GO:0019228)2.65418468
122positive regulation of synapse assembly (GO:0051965)2.63597479
123V(D)J recombination (GO:0033151)2.63158786
124negative regulation of T cell mediated immunity (GO:0002710)2.62582775
125regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62543204
126photoreceptor cell development (GO:0042461)2.62284315
127protein localization to synapse (GO:0035418)2.62221517
128viral genome replication (GO:0019079)2.60963919
129positive regulation of oligodendrocyte differentiation (GO:0048714)2.60722643
130regulation of isotype switching (GO:0045191)2.59608093
131olfactory bulb development (GO:0021772)2.59148413
132alpha-beta T cell activation (GO:0046631)2.58704991
133neurotransmitter-gated ion channel clustering (GO:0072578)2.58413395
134behavioral response to ethanol (GO:0048149)2.57901274
135regulation of respiratory gaseous exchange (GO:0043576)2.57840418
136generation of neurons (GO:0048699)2.56365065
137positive regulation of neurotransmitter secretion (GO:0001956)2.55991159
138positive regulation of tolerance induction (GO:0002645)2.55447821
139regulation of uterine smooth muscle contraction (GO:0070472)2.53268412
140indolalkylamine metabolic process (GO:0006586)2.52841045
141neuron recognition (GO:0008038)2.52340298
142regulation of neurotransmitter uptake (GO:0051580)2.52232491
143CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.52181943
144neuron fate determination (GO:0048664)2.51869593
145DNA integration (GO:0015074)2.50448438
146central nervous system projection neuron axonogenesis (GO:0021952)2.50214172
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50144659
148negative regulation of sodium ion transport (GO:0010766)2.49831727
149ketone body metabolic process (GO:1902224)2.49645135
150opioid receptor signaling pathway (GO:0038003)2.49517935
151DNA double-strand break processing (GO:0000729)2.48833532
152dentate gyrus development (GO:0021542)2.47588513
153regulation of RIG-I signaling pathway (GO:0039535)2.47001367
154neuron-neuron synaptic transmission (GO:0007270)2.46765515
155cornea development in camera-type eye (GO:0061303)2.45791793
156regulation of protein homodimerization activity (GO:0043496)2.45469734
157detection of light stimulus involved in sensory perception (GO:0050962)2.44512713
158detection of light stimulus involved in visual perception (GO:0050908)2.44512713
159positive regulation of DNA recombination (GO:0045911)2.44182458
160neurotransmitter secretion (GO:0007269)2.43710803
161negative regulation of protein localization to cell surface (GO:2000009)2.43703554
162synaptic vesicle exocytosis (GO:0016079)2.43700797
163positive regulation of calcium-mediated signaling (GO:0050850)2.43456894
164ionotropic glutamate receptor signaling pathway (GO:0035235)2.43295236
165positive regulation of synaptic transmission, GABAergic (GO:0032230)2.42988597
166vocalization behavior (GO:0071625)2.42977041
167regulation of oligodendrocyte differentiation (GO:0048713)2.42957117
168retinal rod cell development (GO:0046548)2.42824665
169eye photoreceptor cell development (GO:0042462)2.41826053
170somite development (GO:0061053)2.41362510
171transmission of nerve impulse (GO:0019226)2.38212049
172auditory behavior (GO:0031223)2.37832312
173hindbrain development (GO:0030902)2.36054630
174prenylation (GO:0097354)2.35745890
175protein prenylation (GO:0018342)2.35745890
176preassembly of GPI anchor in ER membrane (GO:0016254)2.34475115
177DNA demethylation (GO:0080111)2.34361032
178cilium movement (GO:0003341)2.34278823
179regulation of glucokinase activity (GO:0033131)2.34101885
180regulation of hexokinase activity (GO:1903299)2.34101885
181positive regulation of mRNA processing (GO:0050685)2.32986079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93898300
2GBX2_23144817_ChIP-Seq_PC3_Human3.87577481
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85605561
4ZNF274_21170338_ChIP-Seq_K562_Hela3.35075330
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84320692
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81049409
7TAF15_26573619_Chip-Seq_HEK293_Human2.77946308
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67323360
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.56315398
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40732758
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.20695491
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19773646
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.19644907
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19193449
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17748175
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09911825
17* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01596654
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00597491
19RUNX_20019798_ChIP-Seq_JUKART_Human1.95163528
20EWS_26573619_Chip-Seq_HEK293_Human1.92377775
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.88561271
22* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86213014
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85290150
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82798734
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82179513
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82126408
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81945525
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80890592
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80132241
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.79907564
31AR_21572438_ChIP-Seq_LNCaP_Human1.78489715
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75782195
33* P300_19829295_ChIP-Seq_ESCs_Human1.73014974
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72658905
35* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70383150
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69813738
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68871546
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67511824
39RNF2_27304074_Chip-Seq_NSC_Mouse1.67004176
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64636115
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.63930276
42* NANOG_18555785_Chip-Seq_ESCs_Mouse1.63877942
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62212704
44* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62212704
45REST_21632747_ChIP-Seq_MESCs_Mouse1.60732671
46* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54899014
47* EED_16625203_ChIP-ChIP_MESCs_Mouse1.53522926
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52698891
49CBP_20019798_ChIP-Seq_JUKART_Human1.52196873
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52196873
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52111299
52* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51398941
53VDR_22108803_ChIP-Seq_LS180_Human1.51061334
54SMAD4_21799915_ChIP-Seq_A2780_Human1.50477578
55* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49373873
56STAT3_18555785_Chip-Seq_ESCs_Mouse1.48320613
57IRF1_19129219_ChIP-ChIP_H3396_Human1.46348085
58P53_22387025_ChIP-Seq_ESCs_Mouse1.45481197
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44852858
60FUS_26573619_Chip-Seq_HEK293_Human1.44459065
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44100466
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43871445
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43843041
64* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43447949
65* BCAT_22108803_ChIP-Seq_LS180_Human1.43162655
66* RNF2_27304074_Chip-Seq_ESCs_Mouse1.43138510
67IGF1R_20145208_ChIP-Seq_DFB_Human1.42417398
68* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41959500
69TP53_22573176_ChIP-Seq_HFKS_Human1.40457151
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.40308216
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40060698
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39792085
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.39016962
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38954613
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.37087119
76NMYC_18555785_Chip-Seq_ESCs_Mouse1.37039159
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36113037
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34961310
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.34531507
80* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33814689
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32890328
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.32389053
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31620403
84P300_18555785_Chip-Seq_ESCs_Mouse1.30713417
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30120096
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30092453
87* TCF4_23295773_ChIP-Seq_U87_Human1.29947541
88* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29035885
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27195140
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.26114253
91* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25807969
92SOX2_19829295_ChIP-Seq_ESCs_Human1.23484491
93NANOG_19829295_ChIP-Seq_ESCs_Human1.23484491
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23324437
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23088241
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22406223
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22208587
98* PRDM14_20953172_ChIP-Seq_ESCs_Human1.21607249
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20167258
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.20023688
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19723267
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.19469483
103PU1_27457419_Chip-Seq_LIVER_Mouse1.18328006
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18291775
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.17401807
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.15777304
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.15501821
108* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15449343
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.14206507
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.12783051
111ER_23166858_ChIP-Seq_MCF-7_Human1.12714819
112ZFX_18555785_Chip-Seq_ESCs_Mouse1.12568610
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.11362985
114* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10609086
115* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10141071
116* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09118768
117* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09076375
118* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09076375
119TCF4_22108803_ChIP-Seq_LS180_Human1.08627426
120* STAT3_23295773_ChIP-Seq_U87_Human1.08438736
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.08299525
122* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07078162
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.06964306
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06809530
125MYC_18940864_ChIP-ChIP_HL60_Human1.06417313
126* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06048394
127* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05833393
128AR_25329375_ChIP-Seq_VCAP_Human1.05137921
129* VDR_23849224_ChIP-Seq_CD4+_Human1.04888576
130* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04816125
131ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02515705
132* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02506615
133EST1_17652178_ChIP-ChIP_JURKAT_Human1.01241426
134GABP_17652178_ChIP-ChIP_JURKAT_Human1.00745048
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98975560
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98833835
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98146162
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97354537
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95075341
140HTT_18923047_ChIP-ChIP_STHdh_Human0.95019901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.69546222
2MP0003880_abnormal_central_pattern3.20652399
3MP0005671_abnormal_response_to3.02944693
4MP0003787_abnormal_imprinting2.93233786
5MP0005646_abnormal_pituitary_gland2.84564694
6MP0005645_abnormal_hypothalamus_physiol2.68581656
7MP0006292_abnormal_olfactory_placode2.63973719
8MP0008877_abnormal_DNA_methylation2.37913143
9MP0006276_abnormal_autonomic_nervous2.35741995
10MP0010386_abnormal_urinary_bladder2.31368975
11MP0001188_hyperpigmentation2.22969377
12MP0002102_abnormal_ear_morphology2.18380282
13MP0000015_abnormal_ear_pigmentation2.16811783
14MP0005075_abnormal_melanosome_morpholog2.16578630
15MP0003879_abnormal_hair_cell2.04712853
16MP0004381_abnormal_hair_follicle2.04286660
17MP0006072_abnormal_retinal_apoptosis2.02480841
18MP0000372_irregular_coat_pigmentation1.90876314
19MP0005360_urolithiasis1.84419217
20MP0001486_abnormal_startle_reflex1.82609871
21MP0003011_delayed_dark_adaptation1.79231810
22MP0004885_abnormal_endolymph1.78136835
23MP0005551_abnormal_eye_electrophysiolog1.76464204
24MP0003635_abnormal_synaptic_transmissio1.75303486
25MP0008789_abnormal_olfactory_epithelium1.74384150
26MP0005409_darkened_coat_color1.73628964
27MP0002163_abnormal_gland_morphology1.71274171
28MP0009745_abnormal_behavioral_response1.68919295
29MP0001502_abnormal_circadian_rhythm1.66778487
30MP0001968_abnormal_touch/_nociception1.66167163
31MP0002572_abnormal_emotion/affect_behav1.65292600
32MP0005253_abnormal_eye_physiology1.65266363
33MP0001905_abnormal_dopamine_level1.64510523
34MP0002876_abnormal_thyroid_physiology1.64216753
35MP0000013_abnormal_adipose_tissue1.63696234
36MP0001984_abnormal_olfaction1.62511397
37MP0002557_abnormal_social/conspecific_i1.61667129
38MP0002933_joint_inflammation1.61325540
39MP0005394_taste/olfaction_phenotype1.59966236
40MP0005499_abnormal_olfactory_system1.59966236
41MP0002733_abnormal_thermal_nociception1.56574877
42MP0002277_abnormal_respiratory_mucosa1.56355912
43MP0001529_abnormal_vocalization1.55173664
44MP0003122_maternal_imprinting1.53722036
45MP0000566_synostosis1.52420489
46MP0005423_abnormal_somatic_nervous1.51409675
47MP0003183_abnormal_peptide_metabolism1.50905713
48MP0002653_abnormal_ependyma_morphology1.50256657
49MP0000631_abnormal_neuroendocrine_gland1.49456716
50MP0002638_abnormal_pupillary_reflex1.48170912
51MP0002064_seizures1.46656456
52MP0002837_dystrophic_cardiac_calcinosis1.42142747
53MP0002063_abnormal_learning/memory/cond1.42018073
54MP0004133_heterotaxia1.41757428
55MP0005379_endocrine/exocrine_gland_phen1.40768090
56MP0002736_abnormal_nociception_after1.40135930
57MP0009046_muscle_twitch1.38038930
58MP0000703_abnormal_thymus_morphology1.36977219
59MP0004043_abnormal_pH_regulation1.36974416
60MP0000778_abnormal_nervous_system1.36476833
61MP0002735_abnormal_chemical_nociception1.35479002
62MP0005084_abnormal_gallbladder_morpholo1.35098114
63MP0004270_analgesia1.34021469
64MP0002184_abnormal_innervation1.33732162
65MP0002095_abnormal_skin_pigmentation1.33245558
66MP0002067_abnormal_sensory_capabilities1.32511015
67MP0008569_lethality_at_weaning1.28156360
68MP0003724_increased_susceptibility_to1.27424853
69MP0002272_abnormal_nervous_system1.26072039
70MP0002751_abnormal_autonomic_nervous1.20634214
71MP0009379_abnormal_foot_pigmentation1.19052455
72MP0002009_preneoplasia1.19019825
73MP0002734_abnormal_mechanical_nocicepti1.18504547
74MP0004859_abnormal_synaptic_plasticity1.17824523
75MP0000049_abnormal_middle_ear1.17514970
76* MP0002398_abnormal_bone_marrow1.17157997
77* MP0002420_abnormal_adaptive_immunity1.16350612
78MP0005387_immune_system_phenotype1.15344539
79MP0001790_abnormal_immune_system1.15344539
80* MP0001819_abnormal_immune_cell1.13116200
81MP0000569_abnormal_digit_pigmentation1.12544589
82MP0001800_abnormal_humoral_immune1.11411178
83MP0002909_abnormal_adrenal_gland1.10716022
84MP0009333_abnormal_splenocyte_physiolog1.10045619
85MP0001501_abnormal_sleep_pattern1.09624735
86MP0000678_abnormal_parathyroid_gland1.09615732
87MP0004924_abnormal_behavior1.09494285
88MP0005386_behavior/neurological_phenoty1.09494285
89MP0002069_abnormal_eating/drinking_beha1.08013717
90MP0003121_genomic_imprinting1.07912736
91MP0004811_abnormal_neuron_physiology1.07188536
92MP0002882_abnormal_neuron_morphology1.06540515
93MP0003195_calcinosis1.06028747
94MP0005171_absent_coat_pigmentation1.04936535
95MP0000538_abnormal_urinary_bladder1.03809628
96MP0002166_altered_tumor_susceptibility1.03362754
97MP0002723_abnormal_immune_serum1.03055667
98MP0005000_abnormal_immune_tolerance1.03000036
99MP0000955_abnormal_spinal_cord1.00397042
100MP0001986_abnormal_taste_sensitivity1.00288663
101* MP0000716_abnormal_immune_system0.99993388
102MP0002822_catalepsy0.99680894
103MP0005187_abnormal_penis_morphology0.99535433
104MP0001963_abnormal_hearing_physiology0.98799662
105MP0001348_abnormal_lacrimal_gland0.98425240
106MP0002177_abnormal_outer_ear0.98032409
107MP0005174_abnormal_tail_pigmentation0.97295761
108MP0000026_abnormal_inner_ear0.96639030
109MP0002752_abnormal_somatic_nervous0.95728152
110MP0003866_abnormal_defecation0.94453056
111MP0001970_abnormal_pain_threshold0.93913842
112MP0001873_stomach_inflammation0.93080098
113MP0000685_abnormal_immune_system0.92986454
114MP0002006_tumorigenesis0.89541990
115MP0002928_abnormal_bile_duct0.89422314
116MP0001485_abnormal_pinna_reflex0.88122919
117MP0008872_abnormal_physiological_respon0.88013448
118MP0002066_abnormal_motor_capabilities/c0.85207596
119* MP0000689_abnormal_spleen_morphology0.83743448
120MP0005408_hypopigmentation0.83560717
121* MP0002722_abnormal_immune_system0.83477443
122MP0009785_altered_susceptibility_to0.83382021
123MP0001835_abnormal_antigen_presentation0.82624612
124MP0004142_abnormal_muscle_tone0.82099248
125MP0004147_increased_porphyrin_level0.81058483
126MP0002452_abnormal_antigen_presenting0.80895872
127MP0004742_abnormal_vestibular_system0.80571203
128MP0002938_white_spotting0.78951262
129MP0001440_abnormal_grooming_behavior0.78544510
130MP0002152_abnormal_brain_morphology0.75829672
131MP0008058_abnormal_DNA_repair0.74790194
132MP0003698_abnormal_male_reproductive0.74246266
133MP0008961_abnormal_basal_metabolism0.73626800
134MP0002229_neurodegeneration0.73127722
135MP0001919_abnormal_reproductive_system0.69499645
136MP0005195_abnormal_posterior_eye0.68796257
137MP0003890_abnormal_embryonic-extraembry0.68150916
138MP0003633_abnormal_nervous_system0.67669921
139MP0005389_reproductive_system_phenotype0.67238780
140MP0001929_abnormal_gametogenesis0.64529883

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.13928198
2Chronic hepatic failure (HP:0100626)4.04042382
3Focal motor seizures (HP:0011153)4.00578536
4Severe combined immunodeficiency (HP:0004430)3.76512388
5Pancreatic cysts (HP:0001737)3.70252798
6Hypothermia (HP:0002045)3.67732049
7Febrile seizures (HP:0002373)3.53262877
8Protruding tongue (HP:0010808)3.47594731
9Polyphagia (HP:0002591)3.44315805
10Nephronophthisis (HP:0000090)3.24329821
11T lymphocytopenia (HP:0005403)3.15677943
12Abnormality of T cell number (HP:0011839)3.12343020
13IgG deficiency (HP:0004315)3.10542485
14IgM deficiency (HP:0002850)2.98821334
15Elevated erythrocyte sedimentation rate (HP:0003565)2.95202742
16Optic nerve coloboma (HP:0000588)2.94560713
17Failure to thrive in infancy (HP:0001531)2.89936298
18Panhypogammaglobulinemia (HP:0003139)2.89863042
19Combined immunodeficiency (HP:0005387)2.87049571
20Abnormality of the labia minora (HP:0012880)2.86615271
21Increased IgM level (HP:0003496)2.84567532
22Type I transferrin isoform profile (HP:0003642)2.82950011
23Progressive cerebellar ataxia (HP:0002073)2.79789026
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.79471322
25Epileptic encephalopathy (HP:0200134)2.75266010
26Intestinal atresia (HP:0011100)2.70714289
27Optic neuritis (HP:0100653)2.67540375
28Retrobulbar optic neuritis (HP:0100654)2.67540375
29Pachygyria (HP:0001302)2.65260853
30Genital tract atresia (HP:0001827)2.64312029
31Vaginal atresia (HP:0000148)2.62335744
32Abnormality of B cell number (HP:0010975)2.62297785
33B lymphocytopenia (HP:0010976)2.62297785
34Severe visual impairment (HP:0001141)2.61786355
35Abnormality of the renal medulla (HP:0100957)2.61086716
36Abnormality of the renal cortex (HP:0011035)2.59363918
37Hyperventilation (HP:0002883)2.55516132
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54691461
39Abnormal protein N-linked glycosylation (HP:0012347)2.54691461
40Abnormal protein glycosylation (HP:0012346)2.54691461
41Abnormal glycosylation (HP:0012345)2.54691461
42Thyroid-stimulating hormone excess (HP:0002925)2.54552572
43Recurrent cutaneous fungal infections (HP:0011370)2.54021358
44Chronic mucocutaneous candidiasis (HP:0002728)2.54021358
45Congenital stationary night blindness (HP:0007642)2.47725246
46Hemiparesis (HP:0001269)2.46430935
47Thyroiditis (HP:0100646)2.46267973
483-Methylglutaconic aciduria (HP:0003535)2.45271130
49Abolished electroretinogram (ERG) (HP:0000550)2.44310964
50Abnormality of midbrain morphology (HP:0002418)2.43954594
51Molar tooth sign on MRI (HP:0002419)2.43954594
52Specific learning disability (HP:0001328)2.43751274
53Broad foot (HP:0001769)2.43056896
54Abnormality of calcium-phosphate metabolism (HP:0100530)2.42758405
55Myositis (HP:0100614)2.42721287
56Stomatitis (HP:0010280)2.40281332
57Hypsarrhythmia (HP:0002521)2.37714492
58Poor coordination (HP:0002370)2.37302204
59Methylmalonic acidemia (HP:0002912)2.36433478
60Abnormality of the fingertips (HP:0001211)2.35378024
61True hermaphroditism (HP:0010459)2.34572528
62EEG with generalized epileptiform discharges (HP:0011198)2.34284918
63Epileptiform EEG discharges (HP:0011182)2.33863396
64Large eyes (HP:0001090)2.32805385
65Gaze-evoked nystagmus (HP:0000640)2.31661317
66Type 2 muscle fiber atrophy (HP:0003554)2.26575570
67Recurrent bronchitis (HP:0002837)2.24537876
68Abnormality of T cells (HP:0002843)2.23728407
69Postaxial hand polydactyly (HP:0001162)2.22953670
70Cystic liver disease (HP:0006706)2.22250021
71Joint swelling (HP:0001386)2.20292170
72Medial flaring of the eyebrow (HP:0010747)2.20176667
73Broad-based gait (HP:0002136)2.17719665
74Large for gestational age (HP:0001520)2.16276100
75Abnormal eating behavior (HP:0100738)2.14496309
76Dialeptic seizures (HP:0011146)2.14492606
77Nephrogenic diabetes insipidus (HP:0009806)2.12941094
78Sclerocornea (HP:0000647)2.12568418
79Growth hormone deficiency (HP:0000824)2.10361603
80Drooling (HP:0002307)2.10019184
81Genetic anticipation (HP:0003743)2.09995588
82Agitation (HP:0000713)2.09022101
83Muscle fiber atrophy (HP:0100295)2.07685906
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.07268198
85Methylmalonic aciduria (HP:0012120)2.07261792
86Absent speech (HP:0001344)2.05683895
87Attenuation of retinal blood vessels (HP:0007843)2.05598304
88Neuroendocrine neoplasm (HP:0100634)2.04553443
89Abnormality of the prostate (HP:0008775)2.03458863
90Retinal dysplasia (HP:0007973)2.02881308
91Hypoplasia of the thymus (HP:0000778)2.02458215
92Optic nerve hypoplasia (HP:0000609)2.01364899
93Anencephaly (HP:0002323)2.01294804
94Colon cancer (HP:0003003)2.00856370
95Blue irides (HP:0000635)1.99764106
96Meningitis (HP:0001287)1.99412811
97Abnormal ciliary motility (HP:0012262)1.99293201
98Poor suck (HP:0002033)1.98187136
99Gait imbalance (HP:0002141)1.98097918
100Focal seizures (HP:0007359)1.97716379
101Type II lissencephaly (HP:0007260)1.96935378
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.96668906
103Narrow nasal bridge (HP:0000446)1.96571082
104Recurrent sinusitis (HP:0011108)1.96163934
105Abnormality of incisor morphology (HP:0011063)1.94869555
106Fair hair (HP:0002286)1.94440012
107Abnormality of eosinophils (HP:0001879)1.94414273
108Excessive salivation (HP:0003781)1.92819688
109Chronic sinusitis (HP:0011109)1.92415656
110Decreased testicular size (HP:0008734)1.92207855
111Pendular nystagmus (HP:0012043)1.91478564
112Amyotrophic lateral sclerosis (HP:0007354)1.90899966
113Autoimmune hemolytic anemia (HP:0001890)1.90784443
114Tongue fasciculations (HP:0001308)1.90580132
115Generalized hypopigmentation of hair (HP:0011358)1.89910665
116Renal cortical cysts (HP:0000803)1.88322177
117Recurrent fungal infections (HP:0002841)1.88267966
118Postaxial foot polydactyly (HP:0001830)1.88168950
119Atonic seizures (HP:0010819)1.87729703
120Abnormality of vitamin B metabolism (HP:0004340)1.87504629
121Chronic diarrhea (HP:0002028)1.85987355
122Sleep apnea (HP:0010535)1.82614328
123Pancreatic fibrosis (HP:0100732)1.81155751
124Congenital hepatic fibrosis (HP:0002612)1.80803300
125Congenital primary aphakia (HP:0007707)1.80405111
126Intellectual disability, moderate (HP:0002342)1.79658167
127Lissencephaly (HP:0001339)1.79429789
128Progressive inability to walk (HP:0002505)1.78480341
129Severe muscular hypotonia (HP:0006829)1.77194909
130Inability to walk (HP:0002540)1.75917993
131Amblyopia (HP:0000646)1.75110730
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74048245
133Prominent nasal bridge (HP:0000426)1.74045584
134Agammaglobulinemia (HP:0004432)1.73562688
135Lymphopenia (HP:0001888)1.73203492
136Pulmonary fibrosis (HP:0002206)1.73177746
137Oligodactyly (hands) (HP:0001180)1.73000678
138Oligodontia (HP:0000677)1.72213204
139Pheochromocytoma (HP:0002666)1.71854821
140Limb dystonia (HP:0002451)1.71311000
141Myokymia (HP:0002411)1.70944513
142Fetal akinesia sequence (HP:0001989)1.70550753
143Flat occiput (HP:0005469)1.69645206
144Orchitis (HP:0100796)1.69553083
145Macroglossia (HP:0000158)1.69312835
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.69147226
147Absent/shortened dynein arms (HP:0200106)1.69147226
148Self-mutilation (HP:0000742)1.68348822
149Absence seizures (HP:0002121)1.68344116
150Chronic otitis media (HP:0000389)1.67661548
151Aplasia/Hypoplasia of the lens (HP:0008063)1.67619813
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.67300745
153Abnormality of the incisor (HP:0000676)1.64852926
154Aplasia/hypoplasia of the uterus (HP:0008684)1.64583341
155Short foot (HP:0001773)1.64508184
156Narrow forehead (HP:0000341)1.64468358
157Exotropia (HP:0000577)1.64301402
158Spastic tetraplegia (HP:0002510)1.64294764
159Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63622462
160Dicarboxylic aciduria (HP:0003215)1.63622462
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63334161
162Broad alveolar ridges (HP:0000187)1.62799172
163Esotropia (HP:0000565)1.62782254
164Alveolar cell carcinoma (HP:0006519)1.62215614
165Renal hypoplasia (HP:0000089)1.60984187
166Cerebellar dysplasia (HP:0007033)1.60913303
167Generalized myoclonic seizures (HP:0002123)1.60819703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.91456990
2CASK4.75826006
3MAP2K73.11528662
4FRK2.88303508
5MAP4K22.76507849
6SGK22.68082438
7YES12.59044120
8MAP4K12.57786901
9TNIK2.38813259
10BCR2.36186440
11SIK32.26463785
12MARK12.25355909
13MAP3K122.14797270
14NLK2.10831573
15PINK12.01721051
16NTRK21.96508563
17PRPF4B1.89362104
18IKBKE1.88046899
19SGK4941.79286727
20SGK2231.79286727
21BMPR1B1.79012964
22MAPK131.71870017
23DAPK21.67529914
24SGK31.66716496
25ZAP701.60017167
26ADRBK21.47202986
27TRIM281.44137110
28SIK21.38130692
29DYRK31.37756421
30ITK1.35226317
31MUSK1.33995081
32SRPK11.32056574
33GRK11.31507649
34KDR1.30830621
35AKT31.29546608
36DAPK11.25624055
37SYK1.24011709
38LIMK11.23853626
39IRAK41.23433923
40MKNK21.21510233
41PNCK1.21407087
42EPHA31.20970960
43PAK31.20839211
44STK161.18761902
45TNK21.16151335
46PRKD31.13305032
47BCKDK1.11913244
48JAK31.08487429
49UHMK11.08406921
50CDK191.07443149
51MINK11.04021672
52BMPR21.02899819
53LCK1.02584586
54ERBB31.02209702
55MAP3K141.01483134
56EPHA41.01314358
57MAP3K41.00725941
58INSRR1.00689523
59RPS6KA40.99972546
60DYRK20.98467686
61FGFR30.96791433
62PRKCH0.95002278
63ACVR1B0.94259296
64TEC0.93585225
65WNK40.92102480
66CDK30.92092900
67IRAK30.90864391
68PRKCE0.90506148
69PHKG20.89199285
70PHKG10.89199285
71GRK70.87945684
72FLT30.87708879
73HIPK20.86578947
74CDK80.86577996
75NTRK30.83978321
76IRAK20.82653513
77CCNB10.81067189
78BLK0.79627725
79IRAK10.78136199
80FGFR40.74774006
81TGFBR10.74127219
82CHUK0.66624879
83PAK60.64839997
84TLK10.63805659
85FES0.63472557
86TESK10.62860820
87JAK10.62276961
88MAP2K40.61766937
89PLK20.61452281
90PRKCQ0.60754299
91CAMK40.59794480
92MKNK10.59711577
93KIT0.58741337
94HCK0.58728724
95RPS6KA50.58653032
96FGFR20.57175229
97WNK30.57046892
98BRD40.56507322
99MAPK40.56427400
100LYN0.53235463
101ADRBK10.50455384
102MST40.49925734
103PRKCG0.49353171
104BTK0.49183696
105NUAK10.49111319
106CAMKK20.48149441
107OXSR10.46827471
108TYK20.46632974
109MAPK150.45959885
110SGK10.44644098
111CDK50.43989644
112GRK60.43653943
113DYRK1A0.42763834
114PRKG10.42215239
115PRKCZ0.41889554
116PRKACA0.41195453
117MARK20.39666815
118CSNK1G20.38920465
119TSSK60.38825360
120CSNK1G10.38427544
121EIF2AK20.38089994
122RPS6KB10.37937576
123CSNK1D0.37322337
124CAMK10.37247621
125VRK10.37095899
126CSNK1A10.36568937
127CSF1R0.35280536
128CAMK2D0.34600570
129ATM0.34433032
130TAOK30.33949909
131CAMK2A0.33739483
132CSNK1G30.32915780
133CSK0.32443136
134ZAK0.32441031
135PASK0.30799706
136STK110.30479290
137STK390.30219168
138MAP2K60.29973122
139DYRK1B0.29184298
140PRKACB0.28658851
141CDK140.28628318
142PKN10.28191320
143IKBKB0.27704119
144CSNK1A1L0.27643162

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.65621992
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.69014377
3Nicotine addiction_Homo sapiens_hsa050332.95629558
4Butanoate metabolism_Homo sapiens_hsa006502.95550496
5T cell receptor signaling pathway_Homo sapiens_hsa046602.72094091
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20690052
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.20578151
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15166355
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14923716
10Autoimmune thyroid disease_Homo sapiens_hsa053202.12785813
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08137216
12Synaptic vesicle cycle_Homo sapiens_hsa047212.07517139
13Graft-versus-host disease_Homo sapiens_hsa053322.04403488
14Allograft rejection_Homo sapiens_hsa053302.00900907
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94679526
16Nitrogen metabolism_Homo sapiens_hsa009101.90132543
17Measles_Homo sapiens_hsa051621.89346707
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.80659902
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75131579
20Steroid biosynthesis_Homo sapiens_hsa001001.71545980
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71410593
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70622294
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66969239
24Morphine addiction_Homo sapiens_hsa050321.59331189
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.55837345
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54928181
27Olfactory transduction_Homo sapiens_hsa047401.54761744
28Type I diabetes mellitus_Homo sapiens_hsa049401.51851170
29Taste transduction_Homo sapiens_hsa047421.50154748
30Serotonergic synapse_Homo sapiens_hsa047261.47124127
31Basal transcription factors_Homo sapiens_hsa030221.43485417
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42092947
33Hematopoietic cell lineage_Homo sapiens_hsa046401.41732209
34Propanoate metabolism_Homo sapiens_hsa006401.40917811
35Protein export_Homo sapiens_hsa030601.37255447
36Selenocompound metabolism_Homo sapiens_hsa004501.35568512
37Insulin secretion_Homo sapiens_hsa049111.33701831
38Peroxisome_Homo sapiens_hsa041461.31553549
39Amphetamine addiction_Homo sapiens_hsa050311.31005571
40Phototransduction_Homo sapiens_hsa047441.30903974
41GABAergic synapse_Homo sapiens_hsa047271.30196725
42Glutamatergic synapse_Homo sapiens_hsa047241.26229412
43RNA degradation_Homo sapiens_hsa030181.21941473
44Circadian rhythm_Homo sapiens_hsa047101.21905405
45Parkinsons disease_Homo sapiens_hsa050121.21318436
46Circadian entrainment_Homo sapiens_hsa047131.14608528
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05044344
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04746045
49Linoleic acid metabolism_Homo sapiens_hsa005911.03978050
50Dopaminergic synapse_Homo sapiens_hsa047281.03229907
51Cholinergic synapse_Homo sapiens_hsa047251.02962849
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02005670
53Wnt signaling pathway_Homo sapiens_hsa043100.99710875
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.99455196
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96129745
56Tryptophan metabolism_Homo sapiens_hsa003800.95651415
57Colorectal cancer_Homo sapiens_hsa052100.95647134
58Cocaine addiction_Homo sapiens_hsa050300.93701744
59Long-term potentiation_Homo sapiens_hsa047200.91932003
60Ether lipid metabolism_Homo sapiens_hsa005650.90920266
61Rheumatoid arthritis_Homo sapiens_hsa053230.90187058
62Vibrio cholerae infection_Homo sapiens_hsa051100.88886033
63Collecting duct acid secretion_Homo sapiens_hsa049660.86003279
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85554433
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.85212828
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84295311
67Axon guidance_Homo sapiens_hsa043600.81191859
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80679707
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80384926
70Herpes simplex infection_Homo sapiens_hsa051680.79631764
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78658887
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78438773
73RNA polymerase_Homo sapiens_hsa030200.78116742
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76939143
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75273765
76Non-homologous end-joining_Homo sapiens_hsa034500.73262858
77Alcoholism_Homo sapiens_hsa050340.72598360
78Renin secretion_Homo sapiens_hsa049240.72249955
79Chemokine signaling pathway_Homo sapiens_hsa040620.71896657
80Fatty acid metabolism_Homo sapiens_hsa012120.68022569
81Calcium signaling pathway_Homo sapiens_hsa040200.66978509
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65337317
83Antigen processing and presentation_Homo sapiens_hsa046120.62085094
84Cardiac muscle contraction_Homo sapiens_hsa042600.61954039
85Shigellosis_Homo sapiens_hsa051310.61327188
86Hepatitis B_Homo sapiens_hsa051610.60487400
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60257532
88Prolactin signaling pathway_Homo sapiens_hsa049170.59884291
89Oxytocin signaling pathway_Homo sapiens_hsa049210.59866099
90Spliceosome_Homo sapiens_hsa030400.59853394
91Inositol phosphate metabolism_Homo sapiens_hsa005620.59444502
92Long-term depression_Homo sapiens_hsa047300.58291037
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57846632
94Hedgehog signaling pathway_Homo sapiens_hsa043400.57018411
95Oocyte meiosis_Homo sapiens_hsa041140.56849946
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55647448
97Notch signaling pathway_Homo sapiens_hsa043300.55571569
98cAMP signaling pathway_Homo sapiens_hsa040240.54834579
99Huntingtons disease_Homo sapiens_hsa050160.54641535
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53513506
101Regulation of autophagy_Homo sapiens_hsa041400.52282129
102Purine metabolism_Homo sapiens_hsa002300.52213160
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51864099
104ABC transporters_Homo sapiens_hsa020100.50849923
105Oxidative phosphorylation_Homo sapiens_hsa001900.50527158
106Osteoclast differentiation_Homo sapiens_hsa043800.49490142
107Proteasome_Homo sapiens_hsa030500.49064252
108Fatty acid elongation_Homo sapiens_hsa000620.48465284
109Salivary secretion_Homo sapiens_hsa049700.46519948
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.46123683
111Caffeine metabolism_Homo sapiens_hsa002320.45209030
112beta-Alanine metabolism_Homo sapiens_hsa004100.44878792
113Viral myocarditis_Homo sapiens_hsa054160.44455843
114MAPK signaling pathway_Homo sapiens_hsa040100.44160183
115Asthma_Homo sapiens_hsa053100.44006970
116Melanogenesis_Homo sapiens_hsa049160.43574353
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43039326
118HTLV-I infection_Homo sapiens_hsa051660.41393679
119Dorso-ventral axis formation_Homo sapiens_hsa043200.41372519
120Gastric acid secretion_Homo sapiens_hsa049710.40997304
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40036041
122N-Glycan biosynthesis_Homo sapiens_hsa005100.38361336
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37456677
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37128659
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37007947
126Metabolic pathways_Homo sapiens_hsa011000.36713364
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36452552
128Ras signaling pathway_Homo sapiens_hsa040140.34317811
129Endometrial cancer_Homo sapiens_hsa052130.34260357
130Alzheimers disease_Homo sapiens_hsa050100.33996264
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33695051
132Fanconi anemia pathway_Homo sapiens_hsa034600.33589758
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33155171
134TNF signaling pathway_Homo sapiens_hsa046680.32687870
135Thyroid cancer_Homo sapiens_hsa052160.31317630
136Retinol metabolism_Homo sapiens_hsa008300.30972819
137Prostate cancer_Homo sapiens_hsa052150.30421443
138mRNA surveillance pathway_Homo sapiens_hsa030150.30338383
139Sulfur metabolism_Homo sapiens_hsa009200.30323372
140Influenza A_Homo sapiens_hsa051640.30124958
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23620933

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