TOX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)4.63669656
2nucleobase catabolic process (GO:0046113)4.61793085
3neuron cell-cell adhesion (GO:0007158)4.38197707
4behavioral response to nicotine (GO:0035095)4.28965547
5endocrine pancreas development (GO:0031018)3.94498866
6presynaptic membrane assembly (GO:0097105)3.92071894
7limb bud formation (GO:0060174)3.80506506
8neuron recognition (GO:0008038)3.71661827
9glandular epithelial cell differentiation (GO:0002067)3.66798342
10regulation of timing of cell differentiation (GO:0048505)3.66707392
11short-term memory (GO:0007614)3.66357447
12dopaminergic neuron differentiation (GO:0071542)3.64467966
13regulation of development, heterochronic (GO:0040034)3.62543645
14presynaptic membrane organization (GO:0097090)3.59481337
15axonal fasciculation (GO:0007413)3.46388267
16neuron fate specification (GO:0048665)3.44862762
17tachykinin receptor signaling pathway (GO:0007217)3.42659367
18hindbrain development (GO:0030902)3.42090394
19type B pancreatic cell development (GO:0003323)3.36842921
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34089285
21layer formation in cerebral cortex (GO:0021819)3.34068011
22olfactory bulb development (GO:0021772)3.33315796
23positive regulation of neuroblast proliferation (GO:0002052)3.29217640
24dendritic spine morphogenesis (GO:0060997)3.26577203
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24952300
26positive regulation of dendritic spine morphogenesis (GO:0061003)3.20247522
27innervation (GO:0060384)3.17669186
28neuronal stem cell maintenance (GO:0097150)3.16582752
29detection of calcium ion (GO:0005513)3.15974233
30retinal ganglion cell axon guidance (GO:0031290)3.15718536
31somite development (GO:0061053)3.10858217
32cardiac ventricle formation (GO:0003211)3.10073877
33central nervous system neuron axonogenesis (GO:0021955)3.10031998
34neuron fate determination (GO:0048664)3.09840583
35midbrain development (GO:0030901)3.07138674
36positive regulation of gastrulation (GO:2000543)3.06044554
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03840883
38postsynaptic membrane organization (GO:0001941)3.02721902
39membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.01732315
40cell migration in hindbrain (GO:0021535)3.00934957
41regulation of synaptic vesicle exocytosis (GO:2000300)2.99634703
42pyrimidine nucleobase catabolic process (GO:0006208)2.96842960
43cerebral cortex radially oriented cell migration (GO:0021799)2.96498796
44kidney morphogenesis (GO:0060993)2.94960209
45microtubule depolymerization (GO:0007019)2.94408249
46astrocyte differentiation (GO:0048708)2.93854631
47hippocampus development (GO:0021766)2.93342535
48neuronal action potential propagation (GO:0019227)2.91100688
49lateral sprouting from an epithelium (GO:0060601)2.90078340
50glandular epithelial cell development (GO:0002068)2.88452995
51synaptic vesicle exocytosis (GO:0016079)2.86420482
52glial cell proliferation (GO:0014009)2.85887629
53cardiac chamber formation (GO:0003207)2.84416157
54insulin secretion (GO:0030073)2.84380338
55positive regulation of synapse assembly (GO:0051965)2.82375132
56neurotransmitter-gated ion channel clustering (GO:0072578)2.82036828
57cornea development in camera-type eye (GO:0061303)2.81656741
58thalamus development (GO:0021794)2.81235576
59negative regulation of oligodendrocyte differentiation (GO:0048715)2.80662818
60regulation of feeding behavior (GO:0060259)2.80286066
61central nervous system neuron development (GO:0021954)2.80095509
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78594127
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76684576
64substrate-independent telencephalic tangential migration (GO:0021826)2.76684576
65spinal cord motor neuron differentiation (GO:0021522)2.76303510
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.76197627
67regulation of translation, ncRNA-mediated (GO:0045974)2.76197627
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76197627
69cerebral cortex cell migration (GO:0021795)2.75827895
70regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74892796
71positive regulation of amino acid transport (GO:0051957)2.74722166
72negative regulation of astrocyte differentiation (GO:0048712)2.73865447
73auditory behavior (GO:0031223)2.73470148
74nonmotile primary cilium assembly (GO:0035058)2.72149245
75regulation of axon guidance (GO:1902667)2.72064423
76left/right axis specification (GO:0070986)2.70629151
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69613919
78cranial nerve development (GO:0021545)2.69586690
79mechanosensory behavior (GO:0007638)2.69321862
80membrane repolarization during action potential (GO:0086011)2.69017980
81cerebellum development (GO:0021549)2.68907885
82glutamate receptor signaling pathway (GO:0007215)2.68152832
83vocalization behavior (GO:0071625)2.67928100
84regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66930865
85inner ear receptor cell development (GO:0060119)2.65714148
86epithelial cell fate commitment (GO:0072148)2.64780545
87intraciliary transport (GO:0042073)2.64214348
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62911498
89ER overload response (GO:0006983)2.61490758
90appendage development (GO:0048736)2.61480710
91limb development (GO:0060173)2.61480710
92forebrain neuron differentiation (GO:0021879)2.60701542
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60379363
94neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.60272539
95synaptic transmission, cholinergic (GO:0007271)2.60220751
96establishment of nucleus localization (GO:0040023)2.59397808
97negative regulation of axon extension (GO:0030517)2.57815267
98regulation of synaptic vesicle transport (GO:1902803)2.57490830
99photoreceptor cell differentiation (GO:0046530)2.56197139
100eye photoreceptor cell differentiation (GO:0001754)2.56197139
101central nervous system projection neuron axonogenesis (GO:0021952)2.55419894
102epithelial cilium movement (GO:0003351)2.54656522
103behavioral response to ethanol (GO:0048149)2.52115841
104calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51865126
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51671334
106negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.51120529
107neuron migration (GO:0001764)2.51024841
108otic vesicle formation (GO:0030916)2.50919630
109retina layer formation (GO:0010842)2.50366236
110startle response (GO:0001964)2.49684477
111regulation of synapse assembly (GO:0051963)2.49365700
112dendrite morphogenesis (GO:0048813)2.48694093
113nephron epithelium morphogenesis (GO:0072088)2.48146908
114nephron tubule morphogenesis (GO:0072078)2.48146908
115forebrain neuron development (GO:0021884)2.47398286
116serotonin metabolic process (GO:0042428)2.47215507
117pituitary gland development (GO:0021983)2.46886787
118positive regulation of neural precursor cell proliferation (GO:2000179)2.46873601
119apical protein localization (GO:0045176)2.46293891
120primitive streak formation (GO:0090009)2.44729109
121regulation of glutamate receptor signaling pathway (GO:1900449)2.44455402
122negative regulation of axon guidance (GO:1902668)2.43455317
123regulation of calcium ion-dependent exocytosis (GO:0017158)2.43305944
124negative regulation of norepinephrine secretion (GO:0010700)2.42655652
125negative regulation of glial cell differentiation (GO:0045686)2.41643035
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41629550
127protein localization to synapse (GO:0035418)2.41581966
128ganglion development (GO:0061548)2.41032763
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40372409
130axon extension (GO:0048675)2.40192367
131synapse assembly (GO:0007416)2.39527619
132regulation of insulin secretion (GO:0050796)2.39382039
133somite rostral/caudal axis specification (GO:0032525)2.38775528
134positive regulation of insulin secretion (GO:0032024)2.38736727
135dendrite development (GO:0016358)2.38679041
136spinal cord development (GO:0021510)2.38564448
137regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37232137
138negative chemotaxis (GO:0050919)2.36032467
139sympathetic nervous system development (GO:0048485)2.35815213
140cell proliferation in forebrain (GO:0021846)2.35798889
141peptide hormone processing (GO:0016486)2.35331754
142negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.35032987
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.34930742
144axon extension involved in axon guidance (GO:0048846)2.34930742
145positive regulation of meiosis (GO:0045836)2.34843071
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33185833
147pancreas development (GO:0031016)2.33074941
148ionotropic glutamate receptor signaling pathway (GO:0035235)2.33062926
149regulation of dendritic spine morphogenesis (GO:0061001)2.33020892
150urinary tract smooth muscle contraction (GO:0014848)2.32594330
151regulation of transcription involved in cell fate commitment (GO:0060850)2.31407500
152transmission of nerve impulse (GO:0019226)2.31134600
153dopamine biosynthetic process (GO:0042416)2.30035996
154regulation of synapse structural plasticity (GO:0051823)2.29243559
155synaptic transmission, glutamatergic (GO:0035249)2.28636327
156cell differentiation in spinal cord (GO:0021515)2.28570587
157primary amino compound metabolic process (GO:1901160)2.28563362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22527822
2GBX2_23144817_ChIP-Seq_PC3_Human3.16183838
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.04474097
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87944256
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62933808
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.57149295
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56951621
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55583096
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.50362757
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.47745378
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46745705
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46745705
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41958713
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41726819
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36740999
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32436071
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28318729
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24706144
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.20737599
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14978834
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.08596658
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05346894
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03919875
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99079759
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96783817
26IGF1R_20145208_ChIP-Seq_DFB_Human1.96707134
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93287951
28* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91101402
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90805600
30RNF2_27304074_Chip-Seq_NSC_Mouse1.90123164
31VDR_22108803_ChIP-Seq_LS180_Human1.89467261
32EWS_26573619_Chip-Seq_HEK293_Human1.84000698
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82694720
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82303233
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76848021
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74147122
37TAF15_26573619_Chip-Seq_HEK293_Human1.72948916
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72476907
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69569111
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62899104
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.60438806
42P300_19829295_ChIP-Seq_ESCs_Human1.59011426
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.56435107
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.51008371
45ZNF274_21170338_ChIP-Seq_K562_Hela1.48751023
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.48093890
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42903543
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.41303880
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37800114
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.37345148
51DROSHA_22980978_ChIP-Seq_HELA_Human1.36637745
52* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36531650
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35797125
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.33945332
55FUS_26573619_Chip-Seq_HEK293_Human1.32384102
56* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30064990
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29452708
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29452708
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27368815
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25824584
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25509735
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24589114
63* STAT3_23295773_ChIP-Seq_U87_Human1.22893481
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22403549
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22371665
66CBP_20019798_ChIP-Seq_JUKART_Human1.22371665
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18760054
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17591501
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.17304340
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.17122359
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16703909
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16215166
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.15753781
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15736230
75* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14971348
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14664267
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14456421
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13688981
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12379543
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.12351436
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.11265776
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.11185041
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10802367
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10684207
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10647607
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10639811
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09962348
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09727195
89SOX9_26525672_Chip-Seq_HEART_Mouse1.09720455
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08777469
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07832807
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06935566
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06106613
94* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06096712
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06088833
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04433901
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03931761
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03667692
99TCF4_22108803_ChIP-Seq_LS180_Human1.02364788
100* AR_25329375_ChIP-Seq_VCAP_Human1.02286318
101* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02151954
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.02117516
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02116096
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.01415939
105TCF4_23295773_ChIP-Seq_U87_Human1.01326901
106AR_21572438_ChIP-Seq_LNCaP_Human1.01313986
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.00944416
108AR_19668381_ChIP-Seq_PC3_Human1.00856659
109BCAT_22108803_ChIP-Seq_LS180_Human1.00446568
110AHR_22903824_ChIP-Seq_MCF-7_Human1.00137952
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.99391748
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99076029
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95737636
114* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95086296
115* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93824690
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93264347
117ER_23166858_ChIP-Seq_MCF-7_Human0.92513607
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92437809
119P53_22387025_ChIP-Seq_ESCs_Mouse0.91798688
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.91207430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.33496936
2MP0003880_abnormal_central_pattern2.66735423
3MP0003787_abnormal_imprinting2.43924400
4MP0004270_analgesia2.43034490
5MP0003136_yellow_coat_color2.38894853
6MP0006292_abnormal_olfactory_placode2.35917595
7MP0000778_abnormal_nervous_system2.35057207
8MP0006276_abnormal_autonomic_nervous2.25631791
9MP0003122_maternal_imprinting2.20155567
10MP0006072_abnormal_retinal_apoptosis2.13122837
11MP0003283_abnormal_digestive_organ2.02609341
12MP0002638_abnormal_pupillary_reflex2.02014343
13MP0001188_hyperpigmentation1.99907614
14MP0004859_abnormal_synaptic_plasticity1.99449927
15MP0002734_abnormal_mechanical_nocicepti1.98616295
16MP0003635_abnormal_synaptic_transmissio1.94597907
17MP0005379_endocrine/exocrine_gland_phen1.92903855
18MP0002751_abnormal_autonomic_nervous1.88829366
19MP0000631_abnormal_neuroendocrine_gland1.87987890
20MP0001293_anophthalmia1.87820012
21MP0009379_abnormal_foot_pigmentation1.87729332
22MP0010386_abnormal_urinary_bladder1.87343808
23MP0003890_abnormal_embryonic-extraembry1.82498401
24MP0002837_dystrophic_cardiac_calcinosis1.79447885
25MP0008789_abnormal_olfactory_epithelium1.77195997
26MP0005645_abnormal_hypothalamus_physiol1.75539153
27MP0005646_abnormal_pituitary_gland1.74277705
28MP0001986_abnormal_taste_sensitivity1.73297450
29MP0009780_abnormal_chondrocyte_physiolo1.73092072
30MP0005423_abnormal_somatic_nervous1.72230272
31MP0002909_abnormal_adrenal_gland1.70169582
32MP0001944_abnormal_pancreas_morphology1.68421350
33MP0002184_abnormal_innervation1.67094191
34MP0005499_abnormal_olfactory_system1.62885742
35MP0005394_taste/olfaction_phenotype1.62885742
36MP0002063_abnormal_learning/memory/cond1.61917393
37MP0002693_abnormal_pancreas_physiology1.60884999
38MP0000678_abnormal_parathyroid_gland1.59839399
39MP0002938_white_spotting1.59194414
40MP0003121_genomic_imprinting1.59099565
41MP0002557_abnormal_social/conspecific_i1.58501199
42MP0002572_abnormal_emotion/affect_behav1.55851350
43MP0002733_abnormal_thermal_nociception1.54259172
44MP0003123_paternal_imprinting1.53652502
45MP0009745_abnormal_behavioral_response1.50335296
46MP0002234_abnormal_pharynx_morphology1.48539667
47MP0004043_abnormal_pH_regulation1.46597473
48MP0000049_abnormal_middle_ear1.45824074
49MP0001968_abnormal_touch/_nociception1.44526986
50MP0001486_abnormal_startle_reflex1.43811282
51MP0002064_seizures1.41679893
52MP0000569_abnormal_digit_pigmentation1.40525087
53MP0002163_abnormal_gland_morphology1.40388134
54MP0003119_abnormal_digestive_system1.38579354
55MP0002735_abnormal_chemical_nociception1.37290301
56MP0001485_abnormal_pinna_reflex1.36252194
57MP0002822_catalepsy1.34751930
58MP0000462_abnormal_digestive_system1.34041705
59MP0000955_abnormal_spinal_cord1.33923384
60MP0002067_abnormal_sensory_capabilities1.33737808
61MP0002272_abnormal_nervous_system1.31883560
62MP0001529_abnormal_vocalization1.30221808
63MP0001286_abnormal_eye_development1.29681956
64MP0001970_abnormal_pain_threshold1.29468317
65MP0000537_abnormal_urethra_morphology1.28456559
66MP0000013_abnormal_adipose_tissue1.28142734
67MP0004858_abnormal_nervous_system1.26614369
68MP0004742_abnormal_vestibular_system1.26481175
69MP0000026_abnormal_inner_ear1.22781502
70MP0003195_calcinosis1.21084549
71MP0003942_abnormal_urinary_system1.21019364
72MP0003315_abnormal_perineum_morphology1.19452365
73MP0005386_behavior/neurological_phenoty1.18795464
74MP0004924_abnormal_behavior1.18795464
75MP0004133_heterotaxia1.17257581
76MP0004142_abnormal_muscle_tone1.16445752
77MP0002882_abnormal_neuron_morphology1.16117248
78MP0005248_abnormal_Harderian_gland1.14549440
79MP0002697_abnormal_eye_size1.13759636
80MP0001984_abnormal_olfaction1.13755375
81MP0002653_abnormal_ependyma_morphology1.13273274
82MP0008961_abnormal_basal_metabolism1.11288781
83MP0002736_abnormal_nociception_after1.09920441
84MP0003385_abnormal_body_wall1.09355938
85MP0010030_abnormal_orbit_morphology1.07993777
86MP0003861_abnormal_nervous_system1.05806102
87MP0003938_abnormal_ear_development1.03871739
88MP0002249_abnormal_larynx_morphology1.02675956
89MP0002177_abnormal_outer_ear1.02584079
90MP0002152_abnormal_brain_morphology1.02515401
91MP0005409_darkened_coat_color1.01593394
92MP0005171_absent_coat_pigmentation1.01550754
93MP0003755_abnormal_palate_morphology1.00816265
94MP0005195_abnormal_posterior_eye0.99531793
95MP0005253_abnormal_eye_physiology0.99438750
96MP0004811_abnormal_neuron_physiology0.99263859
97MP0000538_abnormal_urinary_bladder0.99231408
98MP0000647_abnormal_sebaceous_gland0.97999978
99MP0003937_abnormal_limbs/digits/tail_de0.96817327
100MP0003567_abnormal_fetal_cardiomyocyte0.96637598
101MP0001502_abnormal_circadian_rhythm0.96622490
102MP0002877_abnormal_melanocyte_morpholog0.96444976
103MP0002102_abnormal_ear_morphology0.96439815
104MP0009046_muscle_twitch0.95924455
105MP0002752_abnormal_somatic_nervous0.94875419
106MP0001270_distended_abdomen0.94792479
107MP0003137_abnormal_impulse_conducting0.93837813
108MP0002282_abnormal_trachea_morphology0.93195077
109MP0002116_abnormal_craniofacial_bone0.91875536
110MP0002277_abnormal_respiratory_mucosa0.91575323
111MP0005391_vision/eye_phenotype0.91189748
112MP0009053_abnormal_anal_canal0.90985212
113MP0001324_abnormal_eye_pigmentation0.90718417
114MP0000613_abnormal_salivary_gland0.90709435
115MP0004885_abnormal_endolymph0.90608926
116MP0000534_abnormal_ureter_morphology0.89525950
117MP0001440_abnormal_grooming_behavior0.89212443
118MP0005257_abnormal_intraocular_pressure0.89060636
119MP0001963_abnormal_hearing_physiology0.88599575
120MP0005220_abnormal_exocrine_pancreas0.88453788
121MP0005551_abnormal_eye_electrophysiolog0.87811436
122MP0008995_early_reproductive_senescence0.87465300
123MP0000516_abnormal_urinary_system0.87004259
124MP0005367_renal/urinary_system_phenotyp0.87004259
125MP0001299_abnormal_eye_distance/0.86272685
126MP0002233_abnormal_nose_morphology0.85062917
127MP0003935_abnormal_craniofacial_develop0.83560855
128MP0002066_abnormal_motor_capabilities/c0.83510746
129MP0005187_abnormal_penis_morphology0.82866124
130MP0001905_abnormal_dopamine_level0.80716114

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.95148604
2Abnormality of calcium-phosphate metabolism (HP:0100530)3.28292724
3Focal motor seizures (HP:0011153)3.16855248
4Agitation (HP:0000713)3.10887925
5Hyperinsulinemic hypoglycemia (HP:0000825)2.82987195
6Limb dystonia (HP:0002451)2.77971490
7Broad-based gait (HP:0002136)2.77174190
8Pheochromocytoma (HP:0002666)2.70588425
9Pancreatic cysts (HP:0001737)2.66319597
10Absent eyebrow (HP:0002223)2.65341204
11EEG with generalized epileptiform discharges (HP:0011198)2.64285179
12Epileptiform EEG discharges (HP:0011182)2.61356123
13Hypsarrhythmia (HP:0002521)2.57651658
14Bilateral microphthalmos (HP:0007633)2.56387752
15Abnormality of the renal medulla (HP:0100957)2.56208914
16Progressive cerebellar ataxia (HP:0002073)2.55708495
17Cutaneous finger syndactyly (HP:0010554)2.54364050
18Gait imbalance (HP:0002141)2.50884072
19Intestinal atresia (HP:0011100)2.47684475
20Symptomatic seizures (HP:0011145)2.47147073
21Lissencephaly (HP:0001339)2.44593589
22Hypoglycemic seizures (HP:0002173)2.44144525
23Chronic hepatic failure (HP:0100626)2.44028684
24Medial flaring of the eyebrow (HP:0010747)2.41584181
25Hepatoblastoma (HP:0002884)2.40680267
26Papillary thyroid carcinoma (HP:0002895)2.36404865
27Labial hypoplasia (HP:0000066)2.34823373
28Atonic seizures (HP:0010819)2.31994221
29Vaginal atresia (HP:0000148)2.31658213
30Abnormal pancreas size (HP:0012094)2.31630012
31Hypothermia (HP:0002045)2.31447956
32Diastasis recti (HP:0001540)2.31430648
33Bifid tongue (HP:0010297)2.30996554
34Genital tract atresia (HP:0001827)2.29141248
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27837956
36Hyperventilation (HP:0002883)2.27371300
37Abnormality of the parathyroid morphology (HP:0011766)2.27209533
38Congenital primary aphakia (HP:0007707)2.25808138
39Oligodactyly (hands) (HP:0001180)2.23829254
40Exotropia (HP:0000577)2.23072314
41Febrile seizures (HP:0002373)2.22663617
42Morphological abnormality of the middle ear (HP:0008609)2.22367755
43Abnormal number of incisors (HP:0011064)2.22008431
44Insulin-resistant diabetes mellitus (HP:0000831)2.21630999
45Growth hormone deficiency (HP:0000824)2.21473299
46Neuroendocrine neoplasm (HP:0100634)2.20260812
47Congenital glaucoma (HP:0001087)2.18047186
48Gastrointestinal atresia (HP:0002589)2.17679653
49Amblyopia (HP:0000646)2.17429327
50Decreased circulating renin level (HP:0003351)2.15919083
51Postaxial hand polydactyly (HP:0001162)2.15803263
52Cutaneous syndactyly (HP:0012725)2.15213442
53Visual hallucinations (HP:0002367)2.15036905
54Pachygyria (HP:0001302)2.14489691
55Hypoplastic female external genitalia (HP:0012815)2.12233177
56Thickened helices (HP:0000391)2.11982461
57Epileptic encephalopathy (HP:0200134)2.11110402
58Preaxial foot polydactyly (HP:0001841)2.10253271
59Volvulus (HP:0002580)2.07774488
60Drooling (HP:0002307)2.07697180
61Excessive salivation (HP:0003781)2.07697180
62Retinal dysplasia (HP:0007973)2.05881621
63Concave nail (HP:0001598)2.05635653
64Failure to thrive in infancy (HP:0001531)2.02790707
65Osteomalacia (HP:0002749)2.01349573
66Hyperglycemia (HP:0003074)2.01012574
67Cystic liver disease (HP:0006706)1.99424240
68Hyperthyroidism (HP:0000836)1.98964888
69Aplasia/hypoplasia of the uterus (HP:0008684)1.96836318
70Aplasia/Hypoplasia of the sternum (HP:0006714)1.96382165
71Maternal diabetes (HP:0009800)1.96129823
72Postaxial foot polydactyly (HP:0001830)1.95732355
73Focal seizures (HP:0007359)1.95667958
74Rib fusion (HP:0000902)1.95611500
75Nephrogenic diabetes insipidus (HP:0009806)1.95577778
76Aplasia/Hypoplasia of the lens (HP:0008063)1.93667281
77Atelectasis (HP:0100750)1.92682812
78Hyperparathyroidism (HP:0000843)1.92271385
79Esophageal atresia (HP:0002032)1.91990276
80Shawl scrotum (HP:0000049)1.91404583
81Polyphagia (HP:0002591)1.91354798
82Sclerocornea (HP:0000647)1.89714664
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88713910
84True hermaphroditism (HP:0010459)1.88030096
85Micropenis (HP:0000054)1.87810343
86Anencephaly (HP:0002323)1.86563872
87Abnormal sex determination (HP:0012244)1.86300894
88Sex reversal (HP:0012245)1.86300894
89Renal hypoplasia (HP:0000089)1.86289533
90Thyroid carcinoma (HP:0002890)1.85760592
91Absent septum pellucidum (HP:0001331)1.85388683
92Abnormality of midbrain morphology (HP:0002418)1.84946583
93Molar tooth sign on MRI (HP:0002419)1.84946583
94Midline defect of the nose (HP:0004122)1.84555857
95Specific learning disability (HP:0001328)1.84445806
96Protruding tongue (HP:0010808)1.84379660
97Congenital malformation of the right heart (HP:0011723)1.82622878
98Double outlet right ventricle (HP:0001719)1.82622878
99Preaxial hand polydactyly (HP:0001177)1.81022245
100Popliteal pterygium (HP:0009756)1.79575772
101Abnormality of the pubic bones (HP:0003172)1.79401596
102Anophthalmia (HP:0000528)1.79312851
103Large for gestational age (HP:0001520)1.79160141
104Pendular nystagmus (HP:0012043)1.78526475
105Hypoplasia of the fovea (HP:0007750)1.78341306
106Aplasia/Hypoplasia of the fovea (HP:0008060)1.78341306
107Abnormal hair whorl (HP:0010721)1.78074625
108Hyperglycinemia (HP:0002154)1.76993681
109Type II lissencephaly (HP:0007260)1.76921698
110Postural tremor (HP:0002174)1.76577645
111Megalencephaly (HP:0001355)1.75629879
112Acute necrotizing encephalopathy (HP:0006965)1.75156700
113Dialeptic seizures (HP:0011146)1.75068713
114Congenital sensorineural hearing impairment (HP:0008527)1.74532411
115Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74415100
116Short 4th metacarpal (HP:0010044)1.74415100
117Cupped ear (HP:0000378)1.73779090
118Poor coordination (HP:0002370)1.73302767
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.72596709
120Absence seizures (HP:0002121)1.72175568
121Myokymia (HP:0002411)1.72149580
122Nephronophthisis (HP:0000090)1.70767137
123Decreased testicular size (HP:0008734)1.70612946
124Optic nerve hypoplasia (HP:0000609)1.69847694
125Absent speech (HP:0001344)1.69621364
126Cortical dysplasia (HP:0002539)1.69211687
127Abnormality of the fovea (HP:0000493)1.68183891
128Hemivertebrae (HP:0002937)1.67312548
129Septo-optic dysplasia (HP:0100842)1.67055144
130Chorioretinal coloboma (HP:0000567)1.66570549
131Esotropia (HP:0000565)1.65843228
132Oligodactyly (HP:0012165)1.65644564
133Pancreatic fibrosis (HP:0100732)1.65554273
134Ketoacidosis (HP:0001993)1.65334226
135Acute lymphatic leukemia (HP:0006721)1.65098841
136Patellar aplasia (HP:0006443)1.64865117
137Supranuclear gaze palsy (HP:0000605)1.64606185
138Sporadic (HP:0003745)1.64252098
139Poor suck (HP:0002033)1.62715683
140Progressive sensorineural hearing impairment (HP:0000408)1.62070422
141Supernumerary spleens (HP:0009799)1.62004796
142Tented upper lip vermilion (HP:0010804)1.61846547
143Scrotal hypoplasia (HP:0000046)1.61663057
144Hemiparesis (HP:0001269)1.61197990
145Narrow forehead (HP:0000341)1.61107615
146Abnormality of the renal cortex (HP:0011035)1.60697044
147Hypocalcemia (HP:0002901)1.60268196
148Breast aplasia (HP:0100783)1.60260839
149Hypokalemia (HP:0002900)1.60173088
150Abnormality of the labia minora (HP:0012880)1.60034766
151Alacrima (HP:0000522)1.59835025
152Prolonged QT interval (HP:0001657)1.59121768
153Broad foot (HP:0001769)1.58280462
154Colon cancer (HP:0003003)1.54743791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.54126670
2MARK13.20589281
3CASK3.18904812
4NTRK32.82225248
5BMPR1B2.43750784
6WEE12.41307511
7PNCK2.32562230
8NTRK22.30278705
9MAP3K42.29832979
10MAPK132.27804879
11MAP2K72.20653399
12EPHB22.17144559
13UHMK12.11806382
14WNK32.11748862
15PRKD32.11684548
16KSR12.07332821
17PASK1.89384585
18MAP3K21.82897814
19DYRK21.80056776
20AKT31.79408900
21MKNK11.76199515
22WNK41.70413293
23HIPK21.66259352
24FGFR21.57563579
25MAPK151.57030305
26ERBB31.43610506
27TNIK1.38008933
28MAP4K21.36723743
29IRAK21.36326362
30GRK11.32654462
31SIK21.32403657
32TAOK31.32135978
33DYRK31.31135449
34MAP3K91.29439455
35CDC42BPA1.25867633
36BCR1.24023020
37NME11.21437486
38SGK2231.21100146
39SGK4941.21100146
40STK38L1.21025578
41ADRBK21.13582542
42BRSK21.11415586
43CSNK1G21.09886391
44TYRO31.09077903
45YES11.08597718
46CSNK1G31.06396868
47EPHA31.05869801
48SGK21.05571038
49MINK11.05457693
50SRPK11.03821293
51BRD41.03704743
52CDK91.03677209
53CSNK1A1L1.00628038
54PAK30.96431839
55BRAF0.95405756
56CSNK1G10.94841009
57MAP3K120.94658504
58FRK0.92652499
59GRK50.91454664
60IRAK10.90227291
61VRK10.90205192
62PAK60.90034847
63CDK50.89249823
64CDK80.85305240
65MKNK20.84382391
66BMPR20.83692797
67MAP2K40.83548690
68PLK30.81789162
69STK390.78007974
70DYRK1A0.75125322
71PRKCE0.73132231
72ERBB40.72977734
73WNK10.71469994
74NUAK10.70603143
75PLK20.67253342
76CDC70.67122588
77ACVR1B0.66315023
78STK160.64859140
79CDK30.64270792
80PINK10.63072599
81TAOK10.62575757
82EPHA40.62506650
83CAMK2A0.62438803
84RPS6KA20.62375973
85KSR20.61827167
86OXSR10.61620405
87NTRK10.60104522
88CAMK1G0.57663747
89MELK0.57198911
90CAMK2B0.56011048
91RET0.55760945
92ZAK0.55691184
93PHKG10.55077783
94PHKG20.55077783
95NEK20.54902413
96STK110.54240894
97PIK3CA0.53594971
98SGK10.53488492
99PRKCG0.52447439
100MAP3K10.52374632
101CAMK40.51634248
102CDK140.51574406
103ADRBK10.51360253
104TGFBR10.50847439
105DAPK20.49851501
106NLK0.49157257
107LMTK20.48809172
108PRKD20.48741019
109TRIM280.48680490
110SGK30.48197564
111PLK10.47450380
112PLK40.46829443
113FGFR10.46327655
114ERBB20.46028976
115PRKACA0.45944366
116LIMK10.45839735
117TAF10.44516386
118PRKCZ0.44355074
119CAMK2D0.44070197
120PRKG10.43900470
121STK30.43558778
122CDK180.43021667
123FER0.42829481
124ROCK10.42125370
125PKN10.41731565
126TTK0.41182144
127BRSK10.40052665
128CAMK1D0.39466606
129DYRK1B0.39347804
130CSNK1E0.39247932
131CSNK1A10.38603772
132CDK150.38554570
133LATS10.38415087
134CSNK1D0.33025731

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.91396911
2Protein export_Homo sapiens_hsa030603.09090604
3Insulin secretion_Homo sapiens_hsa049112.76256033
4Nicotine addiction_Homo sapiens_hsa050332.35001916
5Oxidative phosphorylation_Homo sapiens_hsa001902.19565602
6Taste transduction_Homo sapiens_hsa047422.14806887
7GABAergic synapse_Homo sapiens_hsa047272.11434430
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00213254
9Steroid biosynthesis_Homo sapiens_hsa001001.96286485
10Vibrio cholerae infection_Homo sapiens_hsa051101.94434738
11Cocaine addiction_Homo sapiens_hsa050301.91218606
12Serotonergic synapse_Homo sapiens_hsa047261.86893511
13Synaptic vesicle cycle_Homo sapiens_hsa047211.84881470
14Dopaminergic synapse_Homo sapiens_hsa047281.80910204
15Amphetamine addiction_Homo sapiens_hsa050311.80267528
16Circadian entrainment_Homo sapiens_hsa047131.77758101
17Parkinsons disease_Homo sapiens_hsa050121.77591514
18Glutamatergic synapse_Homo sapiens_hsa047241.72341757
19Alzheimers disease_Homo sapiens_hsa050101.70782823
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69738484
21Morphine addiction_Homo sapiens_hsa050321.67277333
22Long-term potentiation_Homo sapiens_hsa047201.65678350
23Type I diabetes mellitus_Homo sapiens_hsa049401.64231438
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62214864
25Nitrogen metabolism_Homo sapiens_hsa009101.60515751
26Sulfur metabolism_Homo sapiens_hsa009201.53894745
27Cholinergic synapse_Homo sapiens_hsa047251.51664997
28Axon guidance_Homo sapiens_hsa043601.49050553
29Collecting duct acid secretion_Homo sapiens_hsa049661.48656017
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47900796
31Type II diabetes mellitus_Homo sapiens_hsa049301.45033970
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40617868
33Huntingtons disease_Homo sapiens_hsa050161.39861929
34Cardiac muscle contraction_Homo sapiens_hsa042601.36033841
35Long-term depression_Homo sapiens_hsa047301.35904563
36Hedgehog signaling pathway_Homo sapiens_hsa043401.31168312
37Melanogenesis_Homo sapiens_hsa049161.30593400
38Dorso-ventral axis formation_Homo sapiens_hsa043201.25942744
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23084896
40Propanoate metabolism_Homo sapiens_hsa006401.23083719
41Gap junction_Homo sapiens_hsa045401.15185352
42Renin secretion_Homo sapiens_hsa049241.14704039
43Linoleic acid metabolism_Homo sapiens_hsa005911.14452194
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14192456
45Phototransduction_Homo sapiens_hsa047441.11609115
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11391075
47Basal transcription factors_Homo sapiens_hsa030221.10736065
48Olfactory transduction_Homo sapiens_hsa047401.09202642
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08307274
50Tryptophan metabolism_Homo sapiens_hsa003801.08268680
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07705177
52Wnt signaling pathway_Homo sapiens_hsa043101.06887205
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04177028
54Basal cell carcinoma_Homo sapiens_hsa052171.00950038
55Estrogen signaling pathway_Homo sapiens_hsa049151.00742022
56Fanconi anemia pathway_Homo sapiens_hsa034600.96129521
57Fat digestion and absorption_Homo sapiens_hsa049750.96122776
58Gastric acid secretion_Homo sapiens_hsa049710.95851519
59beta-Alanine metabolism_Homo sapiens_hsa004100.95484651
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94674390
61GnRH signaling pathway_Homo sapiens_hsa049120.94197200
62Regulation of autophagy_Homo sapiens_hsa041400.94037359
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93901670
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93112134
65Circadian rhythm_Homo sapiens_hsa047100.91615026
66Alcoholism_Homo sapiens_hsa050340.91434711
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91432050
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.91058773
69RNA degradation_Homo sapiens_hsa030180.90135930
70Retinol metabolism_Homo sapiens_hsa008300.89621641
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87661104
72Histidine metabolism_Homo sapiens_hsa003400.86671707
73Butanoate metabolism_Homo sapiens_hsa006500.86268110
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83141006
75Salivary secretion_Homo sapiens_hsa049700.82964354
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81560494
77Ether lipid metabolism_Homo sapiens_hsa005650.81287128
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.80670498
79Pancreatic secretion_Homo sapiens_hsa049720.79437226
80Selenocompound metabolism_Homo sapiens_hsa004500.77408466
81Endometrial cancer_Homo sapiens_hsa052130.77078108
82Oxytocin signaling pathway_Homo sapiens_hsa049210.76762079
83Thyroid hormone synthesis_Homo sapiens_hsa049180.76606930
84cAMP signaling pathway_Homo sapiens_hsa040240.76465287
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76325696
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74015937
87TGF-beta signaling pathway_Homo sapiens_hsa043500.72719643
88Vitamin digestion and absorption_Homo sapiens_hsa049770.72575829
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72154872
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.71711280
91Prion diseases_Homo sapiens_hsa050200.71554899
92ErbB signaling pathway_Homo sapiens_hsa040120.70603537
93Chemical carcinogenesis_Homo sapiens_hsa052040.70403374
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69996660
95Lysine degradation_Homo sapiens_hsa003100.69451954
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68987674
97Renal cell carcinoma_Homo sapiens_hsa052110.68200461
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67957989
99Oocyte meiosis_Homo sapiens_hsa041140.67592361
100Calcium signaling pathway_Homo sapiens_hsa040200.67247958
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66681031
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66463558
103Fatty acid degradation_Homo sapiens_hsa000710.65407453
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63991968
105Fatty acid biosynthesis_Homo sapiens_hsa000610.63214821
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63082154
107Glioma_Homo sapiens_hsa052140.62609049
108Hippo signaling pathway_Homo sapiens_hsa043900.62002359
109Peroxisome_Homo sapiens_hsa041460.60176572
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58533979
111Caffeine metabolism_Homo sapiens_hsa002320.57640707
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57639259
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57458262
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56305911
115Ribosome_Homo sapiens_hsa030100.55930164
116Glucagon signaling pathway_Homo sapiens_hsa049220.54801909
117Homologous recombination_Homo sapiens_hsa034400.54188965
118Prolactin signaling pathway_Homo sapiens_hsa049170.53353183
119Colorectal cancer_Homo sapiens_hsa052100.53170902
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52940308
121Ovarian steroidogenesis_Homo sapiens_hsa049130.52647386
122mRNA surveillance pathway_Homo sapiens_hsa030150.52644405
123N-Glycan biosynthesis_Homo sapiens_hsa005100.52369876
124Dilated cardiomyopathy_Homo sapiens_hsa054140.51647718
125Notch signaling pathway_Homo sapiens_hsa043300.51485498
126ABC transporters_Homo sapiens_hsa020100.50921494
127Fatty acid metabolism_Homo sapiens_hsa012120.50827575
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50043318
129Ras signaling pathway_Homo sapiens_hsa040140.48785797
130Glycerolipid metabolism_Homo sapiens_hsa005610.48651276
131MAPK signaling pathway_Homo sapiens_hsa040100.47326481
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46995448
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46749685
134Melanoma_Homo sapiens_hsa052180.46497366
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46381592
136Folate biosynthesis_Homo sapiens_hsa007900.44723526
137Mineral absorption_Homo sapiens_hsa049780.44531294
138Insulin signaling pathway_Homo sapiens_hsa049100.42872571
139Prostate cancer_Homo sapiens_hsa052150.41845268
140Tight junction_Homo sapiens_hsa045300.39581966
141Choline metabolism in cancer_Homo sapiens_hsa052310.39074578
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38973405
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37485421
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37335727
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35098705

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