TOX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tyrosine phosphorylation of STAT protein (GO:0007260)7.46030931
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.38737515
3water-soluble vitamin biosynthetic process (GO:0042364)5.82019559
4negative regulation of DNA-templated transcription, elongation (GO:0032785)5.52282153
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.52282153
6positive regulation of interleukin-17 production (GO:0032740)4.89633266
7DNA unwinding involved in DNA replication (GO:0006268)4.65723218
8regulation of B cell receptor signaling pathway (GO:0050855)4.50656755
9regulation of platelet aggregation (GO:0090330)4.40196497
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.39815695
11DNA deamination (GO:0045006)4.37020108
12regulation of interleukin-2 biosynthetic process (GO:0045076)4.35352331
13positive regulation of gamma-delta T cell activation (GO:0046645)4.29489500
14positive regulation of interleukin-2 production (GO:0032743)4.19273956
15sulfation (GO:0051923)4.15476153
16protein complex biogenesis (GO:0070271)4.15054305
17regulation of cell proliferation involved in kidney development (GO:1901722)4.13722348
18cellular zinc ion homeostasis (GO:0006882)4.12017034
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.07710522
20NADH dehydrogenase complex assembly (GO:0010257)4.07710522
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07710522
22cellular response to ATP (GO:0071318)4.06722958
23behavioral response to nicotine (GO:0035095)4.05959950
24protein K6-linked ubiquitination (GO:0085020)3.84563554
25regulation of glomerulus development (GO:0090192)3.80445296
26protein polyglutamylation (GO:0018095)3.75781564
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74497644
28gamma-aminobutyric acid transport (GO:0015812)3.73709646
29mitochondrial respiratory chain complex assembly (GO:0033108)3.67535598
30regulation of translational termination (GO:0006449)3.66874005
31L-fucose catabolic process (GO:0042355)3.64617515
32fucose catabolic process (GO:0019317)3.64617515
33L-fucose metabolic process (GO:0042354)3.64617515
34regulation of platelet activation (GO:0010543)3.63035079
35regulation of type B pancreatic cell apoptotic process (GO:2000674)3.59435826
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59422392
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59422392
38antigen processing and presentation of endogenous antigen (GO:0019883)3.57792157
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.57228653
40positive regulation of protein autophosphorylation (GO:0031954)3.48852519
41negative regulation of protein autophosphorylation (GO:0031953)3.48057364
42tryptophan metabolic process (GO:0006568)3.47180363
43GPI anchor metabolic process (GO:0006505)3.47016752
44indole-containing compound catabolic process (GO:0042436)3.46470911
45indolalkylamine catabolic process (GO:0046218)3.46470911
46tryptophan catabolic process (GO:0006569)3.46470911
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.42953289
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.42953289
49platelet dense granule organization (GO:0060155)3.42602519
50regulation of interleukin-17 production (GO:0032660)3.41499254
51regulation of glucokinase activity (GO:0033131)3.40374260
52regulation of hexokinase activity (GO:1903299)3.40374260
53negative regulation of acute inflammatory response (GO:0002674)3.39716695
54histone H3-K4 trimethylation (GO:0080182)3.38046200
55regulation of gamma-delta T cell differentiation (GO:0045586)3.35656905
56respiratory chain complex IV assembly (GO:0008535)3.35493797
57positive regulation by symbiont of host defense response (GO:0052509)3.35156694
58modulation by symbiont of host defense response (GO:0052031)3.35156694
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35156694
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35156694
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.35156694
62modulation by symbiont of host immune response (GO:0052553)3.35156694
63preassembly of GPI anchor in ER membrane (GO:0016254)3.33022805
64regulation of nucleobase-containing compound transport (GO:0032239)3.32916973
65indolalkylamine metabolic process (GO:0006586)3.28539574
66mannosylation (GO:0097502)3.28451859
67protein-cofactor linkage (GO:0018065)3.28328381
68negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.25160784
69positive regulation of glycolytic process (GO:0045821)3.24791130
70negative regulation of T cell apoptotic process (GO:0070233)3.24657783
71zinc ion homeostasis (GO:0055069)3.24454928
72regulation of action potential (GO:0098900)3.22480570
73kynurenine metabolic process (GO:0070189)3.22281675
74leukocyte aggregation (GO:0070486)3.20609884
75negative regulation of systemic arterial blood pressure (GO:0003085)3.20183632
76positive regulation of interleukin-4 production (GO:0032753)3.18397052
77G1 DNA damage checkpoint (GO:0044783)3.18344241
78regulation of gamma-delta T cell activation (GO:0046643)3.17312684
79regulation of fibroblast apoptotic process (GO:2000269)3.15309379
80negative regulation of telomere maintenance (GO:0032205)3.14842998
81cytochrome complex assembly (GO:0017004)3.14250601
82negative regulation of protein tyrosine kinase activity (GO:0061099)3.13712397
83nuclear pore complex assembly (GO:0051292)3.13423390
84regulation of interleukin-12 biosynthetic process (GO:0045075)3.11919628
85regulation of protein autophosphorylation (GO:0031952)3.09743324
86negative regulation by host of viral transcription (GO:0043922)3.09638695
87regulation of T cell apoptotic process (GO:0070232)3.05376861
88negative regulation of protein oligomerization (GO:0032460)3.03960961
89B cell receptor signaling pathway (GO:0050853)3.03495008
90aggressive behavior (GO:0002118)3.01572191
91positive regulation of cell size (GO:0045793)3.01118180
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.00460333
93negative regulation of B cell proliferation (GO:0030889)2.99414624
94histone H2B ubiquitination (GO:0033523)2.96942548
95axoneme assembly (GO:0035082)2.92694779
96negative regulation of fibroblast apoptotic process (GO:2000270)2.91934584
97adaptation of signaling pathway (GO:0023058)2.90242934
98cellular response to zinc ion (GO:0071294)2.89086520
99adenosine receptor signaling pathway (GO:0001973)2.88789101
100positive regulation of B cell differentiation (GO:0045579)2.88448862
101regulation of homotypic cell-cell adhesion (GO:0034110)2.85718410
102neuronal action potential (GO:0019228)2.85486045
103RNA destabilization (GO:0050779)2.84150573
104regulation of DNA endoreduplication (GO:0032875)2.84039368
105nucleotide transmembrane transport (GO:1901679)2.83055802
106kidney morphogenesis (GO:0060993)2.82318370
107establishment of protein localization to Golgi (GO:0072600)2.81199837
108cellular response to exogenous dsRNA (GO:0071360)2.78439162
109positive regulation of respiratory burst (GO:0060267)2.78120914
110positive regulation by host of viral transcription (GO:0043923)2.76384851
111detection of light stimulus involved in sensory perception (GO:0050962)2.76162153
112detection of light stimulus involved in visual perception (GO:0050908)2.76162153
113regulation of interleukin-2 production (GO:0032663)2.75093293
114positive regulation of fatty acid oxidation (GO:0046321)2.74335844
115negative T cell selection (GO:0043383)2.74113486
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73659409
117positive regulation of interferon-alpha production (GO:0032727)2.73143502
118positive regulation of DNA-templated transcription, initiation (GO:2000144)2.72883983
119positive regulation of cytokine biosynthetic process (GO:0042108)2.72748770
120macrophage activation involved in immune response (GO:0002281)2.71758385
121protein targeting to Golgi (GO:0000042)2.71375470
122vascular endothelial growth factor signaling pathway (GO:0038084)2.71253523
123regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.70072725
124positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.69520950
125regulation of phospholipid biosynthetic process (GO:0071071)2.69518267
126regulation of B cell differentiation (GO:0045577)2.69258233
127positive regulation of T cell apoptotic process (GO:0070234)2.69122414
128regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.67640953
129phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67506581
130dentate gyrus development (GO:0021542)2.66962338
131negative thymic T cell selection (GO:0045060)2.66543013
132inositol phosphate catabolic process (GO:0071545)2.65173292
133myeloid dendritic cell activation (GO:0001773)2.64877114
134myeloid dendritic cell differentiation (GO:0043011)2.64289974
135nuclear pore organization (GO:0006999)2.64261752
136GPI anchor biosynthetic process (GO:0006506)2.63993215
137piRNA metabolic process (GO:0034587)2.61936073
138regulation of interferon-beta biosynthetic process (GO:0045357)2.61774178
139regulation of interferon-alpha production (GO:0032647)2.61293896
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60967677
141immunoglobulin mediated immune response (GO:0016064)2.60096870
142positive regulation of glomerulus development (GO:0090193)2.59755219
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.59388206
144regulation of T-helper 1 cell differentiation (GO:0045625)2.58085500
145regulation of lymphocyte apoptotic process (GO:0070228)2.57541358
146negative regulation of lymphocyte apoptotic process (GO:0070229)2.57095605
147pharyngeal system development (GO:0060037)2.56948903
148positive regulation of lymphocyte apoptotic process (GO:0070230)2.56849078
149T-helper 1 type immune response (GO:0042088)2.56721337
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56622955
151vitamin biosynthetic process (GO:0009110)2.56501568
152somite development (GO:0061053)2.56403092
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56142485
154T cell homeostasis (GO:0043029)2.56043383
155antigen receptor-mediated signaling pathway (GO:0050851)2.54464833
156negative regulation of epidermal cell differentiation (GO:0045605)2.54458095
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52038213
158positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51927151
159positive regulation of interleukin-12 production (GO:0032735)2.50449401
160response to interleukin-15 (GO:0070672)2.50224058
161mitotic sister chromatid cohesion (GO:0007064)2.50021965
162Notch signaling involved in heart development (GO:0061314)2.48563276
163zinc ion transmembrane transport (GO:0071577)2.48021487
164regulation of proton transport (GO:0010155)2.47823893
165cellular ketone body metabolic process (GO:0046950)2.47516450
166regulation of retinoic acid receptor signaling pathway (GO:0048385)2.47332613
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.46386969
168retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46309933
169regulation of alpha-beta T cell proliferation (GO:0046640)2.46261850
170T cell receptor signaling pathway (GO:0050852)2.46111789
171regulation of interleukin-4 production (GO:0032673)2.45942964
172nitric oxide mediated signal transduction (GO:0007263)2.45775393
173microglial cell activation (GO:0001774)2.45763758
174lactate metabolic process (GO:0006089)2.45283711
175thyroid hormone metabolic process (GO:0042403)2.44660591
176C-terminal protein lipidation (GO:0006501)2.44540643
177negative regulation of insulin receptor signaling pathway (GO:0046627)2.43639098
178indole-containing compound metabolic process (GO:0042430)2.43208630
179negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.41545163
180endocrine pancreas development (GO:0031018)2.40590246
181cellular response to type I interferon (GO:0071357)2.40449316
182type I interferon signaling pathway (GO:0060337)2.40449316
183protein sumoylation (GO:0016925)2.39474231
184keratinocyte development (GO:0003334)2.39232095
185regulation of germinal center formation (GO:0002634)2.39213447
186negative regulation of response to food (GO:0032096)2.38320981
187negative regulation of appetite (GO:0032099)2.38320981
188protein localization to Golgi apparatus (GO:0034067)2.36572758
189mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36552040
190regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36332995
191polyol catabolic process (GO:0046174)2.35750471
192negative regulation of cell cycle arrest (GO:0071157)2.33405568
193transepithelial transport (GO:0070633)2.32890962
194positive regulation of cardiac muscle cell differentiation (GO:2000727)2.31708593
195RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.31513647
196photoreceptor cell development (GO:0042461)2.31378897
197C-terminal protein amino acid modification (GO:0018410)2.30966448
198negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30959124
199negative regulation of synaptic transmission, GABAergic (GO:0032229)2.30026880
200regulation of triglyceride biosynthetic process (GO:0010866)2.29868348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57010019
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.30830786
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.75522680
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.59190005
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.36644212
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.30273172
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.77788583
8ZNF274_21170338_ChIP-Seq_K562_Hela3.77071205
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16965918
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13021410
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07500865
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.03987547
13GBX2_23144817_ChIP-Seq_PC3_Human3.01349183
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.99614660
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96180268
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.92049776
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84477125
18MYC_22102868_ChIP-Seq_BL_Human2.83247294
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.72201839
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71077126
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64891506
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.63645448
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61838717
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61135391
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.58671460
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52209347
27RUNX_20019798_ChIP-Seq_JUKART_Human2.51941106
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51051817
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47607355
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47048318
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46291348
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46097170
33MYB_26560356_Chip-Seq_TH2_Human2.35429808
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32664481
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31104831
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31008520
37IGF1R_20145208_ChIP-Seq_DFB_Human2.24652130
38VDR_22108803_ChIP-Seq_LS180_Human2.23024828
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21918971
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16629063
41EWS_26573619_Chip-Seq_HEK293_Human2.13767067
42FLI1_27457419_Chip-Seq_LIVER_Mouse2.12516028
43ER_23166858_ChIP-Seq_MCF-7_Human2.00322887
44MYB_26560356_Chip-Seq_TH1_Human1.99701096
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99113898
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95316726
47UTX_26944678_Chip-Seq_JUKART_Human1.83027605
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.81950058
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74006554
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73858099
51* VDR_23849224_ChIP-Seq_CD4+_Human1.72779270
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70928096
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.68452385
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67469937
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67444638
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66101790
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66101790
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66101790
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63500942
60FUS_26573619_Chip-Seq_HEK293_Human1.56625767
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55654091
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55223979
63* SPI1_23547873_ChIP-Seq_NB4_Human1.54514925
64P300_19829295_ChIP-Seq_ESCs_Human1.51311357
65VDR_24763502_ChIP-Seq_THP-1_Human1.51040150
66MAF_26560356_Chip-Seq_TH1_Human1.50093005
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.49106377
68VDR_21846776_ChIP-Seq_THP-1_Human1.48985102
69MYC_18940864_ChIP-ChIP_HL60_Human1.46858140
70CIITA_25753668_ChIP-Seq_RAJI_Human1.45904468
71SCL_19346495_ChIP-Seq_HPC-7_Human1.45752187
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43619729
73CBP_20019798_ChIP-Seq_JUKART_Human1.43619729
74IRF1_19129219_ChIP-ChIP_H3396_Human1.41453316
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40404956
76TP53_22573176_ChIP-Seq_HFKS_Human1.40005229
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35689300
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34738194
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.34738194
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33887370
81* ETS1_20019798_ChIP-Seq_JURKAT_Human1.33609882
82BCAT_22108803_ChIP-Seq_LS180_Human1.33384065
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.32746165
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32554605
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32181006
86SMAD4_21799915_ChIP-Seq_A2780_Human1.31784194
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30505902
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.30480788
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29571087
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28139432
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27438401
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26845077
93TCF7_22412390_ChIP-Seq_EML_Mouse1.26774173
94* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26332860
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25989674
96CDX2_22108803_ChIP-Seq_LS180_Human1.25876215
97SOX2_19829295_ChIP-Seq_ESCs_Human1.25803016
98NANOG_19829295_ChIP-Seq_ESCs_Human1.25803016
99STAT3_23295773_ChIP-Seq_U87_Human1.25403829
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25142936
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24256692
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23689137
103* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23339142
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21476725
105PU_27001747_Chip-Seq_BMDM_Mouse1.20705688
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20621803
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18984480
108* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18773296
109TCF4_23295773_ChIP-Seq_U87_Human1.18701578
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18100341
111AR_20517297_ChIP-Seq_VCAP_Human1.17972144
112GATA3_27048872_Chip-Seq_THYMUS_Human1.17426704
113AR_25329375_ChIP-Seq_VCAP_Human1.17196006
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17066463
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16528256
116NCOR_22424771_ChIP-Seq_293T_Human1.15926316
117KDM2B_26808549_Chip-Seq_DND41_Human1.15112368
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14927091
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14787745
120TAF15_26573619_Chip-Seq_HEK293_Human1.14443957
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14327150
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.13547542
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12170864
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11541081
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.11156489
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11077638
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09489216
128VDR_24787735_ChIP-Seq_THP-1_Human1.09300744
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.09123051
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08904769
131EZH2_27294783_Chip-Seq_NPCs_Mouse1.07827172
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.07742033
133AHR_22903824_ChIP-Seq_MCF-7_Human1.07730248
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07399801
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05470946
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05217466
137TCF4_22108803_ChIP-Seq_LS180_Human1.04957909
138EZH2_22144423_ChIP-Seq_EOC_Human1.04843993
139P53_22387025_ChIP-Seq_ESCs_Mouse1.04745878
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04743385
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03436427
142TFEB_21752829_ChIP-Seq_HELA_Human1.03137806
143TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02027502
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01664876
145AR_21572438_ChIP-Seq_LNCaP_Human1.01200471
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00926916
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00810770
148GATA3_21878914_ChIP-Seq_MCF-7_Human1.00734814
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00585624
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00413728
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00155843
152FLI1_21867929_ChIP-Seq_TH2_Mouse1.00072873
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00008804
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.99215115
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98347202
156PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98185497
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97939573
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97893034
159SALL1_21062744_ChIP-ChIP_HESCs_Human0.96808282
160HOXB7_26014856_ChIP-Seq_BT474_Human0.96715055
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.96156365
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96118273
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.94755138
164* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94333915
165MAF_26560356_Chip-Seq_TH2_Human0.93144455
166E2F1_21310950_ChIP-Seq_MCF-7_Human0.91699732
167SPI1_23127762_ChIP-Seq_K562_Human0.91080421
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90522440
169* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89857586
170ESR1_21235772_ChIP-Seq_MCF-7_Human0.89707665
171KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89518623
172CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88384392
173ELK1_19687146_ChIP-ChIP_HELA_Human0.85796538
174* GATA3_26560356_Chip-Seq_TH2_Human0.84538021
175CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82954297
176CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82878013
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82238961
178THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79757081
179TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77697481
180* FOXP3_21729870_ChIP-Seq_TREG_Human0.77625144
181HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75377926
182FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74598506
183MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74590190
184MYC_18555785_ChIP-Seq_MESCs_Mouse0.73893752
185GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73742168
186* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72307320
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70424382
188MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.69227868
189PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67712285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.59677381
2MP0009780_abnormal_chondrocyte_physiolo4.23169937
3MP0008057_abnormal_DNA_replication3.78229964
4MP0001661_extended_life_span3.64143047
5MP0003941_abnormal_skin_development3.55593137
6MP0001835_abnormal_antigen_presentation3.45857439
7MP0002876_abnormal_thyroid_physiology3.17262685
8MP0004185_abnormal_adipocyte_glucose3.16158819
9MP0005646_abnormal_pituitary_gland2.98667126
10MP0003763_abnormal_thymus_physiology2.92303679
11MP0009333_abnormal_splenocyte_physiolog2.88815598
12MP0005000_abnormal_immune_tolerance2.66639986
13MP0005671_abnormal_response_to2.65986153
14MP0003724_increased_susceptibility_to2.54363382
15MP0002837_dystrophic_cardiac_calcinosis2.44984470
16MP0001800_abnormal_humoral_immune2.43570085
17MP0003303_peritoneal_inflammation2.35495988
18MP0005171_absent_coat_pigmentation2.30060596
19MP0002102_abnormal_ear_morphology2.27284802
20MP0002723_abnormal_immune_serum2.22599034
21MP0003436_decreased_susceptibility_to2.21329163
22MP0002138_abnormal_hepatobiliary_system2.19600932
23MP0002452_abnormal_antigen_presenting2.19590001
24MP0001986_abnormal_taste_sensitivity2.13805059
25MP0002163_abnormal_gland_morphology2.11551226
26MP0002405_respiratory_system_inflammati2.07309446
27MP0001958_emphysema2.05701252
28MP0002420_abnormal_adaptive_immunity2.05079822
29MP0005387_immune_system_phenotype2.04358352
30MP0001790_abnormal_immune_system2.04358352
31MP0001819_abnormal_immune_cell2.03931715
32MP0002166_altered_tumor_susceptibility2.03866074
33MP0002006_tumorigenesis2.03504533
34MP0005551_abnormal_eye_electrophysiolog2.02751950
35MP0009785_altered_susceptibility_to2.02583540
36MP0002398_abnormal_bone_marrow2.01811677
37MP0008872_abnormal_physiological_respon2.00066275
38MP0002419_abnormal_innate_immunity1.99021475
39MP0005025_abnormal_response_to1.97951163
40MP0005464_abnormal_platelet_physiology1.94347485
41MP0002928_abnormal_bile_duct1.88928447
42MP0002396_abnormal_hematopoietic_system1.87519980
43MP0005379_endocrine/exocrine_gland_phen1.87517724
44MP0002148_abnormal_hypersensitivity_rea1.86338508
45MP0002160_abnormal_reproductive_system1.85374220
46MP0002638_abnormal_pupillary_reflex1.82606573
47MP0003646_muscle_fatigue1.82325920
48MP0004808_abnormal_hematopoietic_stem1.80651207
49MP0000685_abnormal_immune_system1.80005872
50MP0000703_abnormal_thymus_morphology1.76934344
51MP0003300_gastrointestinal_ulcer1.76142112
52MP0005084_abnormal_gallbladder_morpholo1.75449162
53MP0000427_abnormal_hair_cycle1.73623834
54MP0004885_abnormal_endolymph1.70265407
55MP0010094_abnormal_chromosome_stability1.67675735
56MP0003011_delayed_dark_adaptation1.67344466
57MP0000716_abnormal_immune_system1.66600274
58MP0008875_abnormal_xenobiotic_pharmacok1.63871301
59MP0002722_abnormal_immune_system1.62295599
60MP0000689_abnormal_spleen_morphology1.60265491
61MP0002877_abnormal_melanocyte_morpholog1.59890252
62MP0006072_abnormal_retinal_apoptosis1.58812061
63MP0004145_abnormal_muscle_electrophysio1.55653928
64MP0004134_abnormal_chest_morphology1.51413324
65MP0004142_abnormal_muscle_tone1.50325996
66MP0010155_abnormal_intestine_physiology1.49263896
67MP0008007_abnormal_cellular_replicative1.48392790
68MP0006292_abnormal_olfactory_placode1.47525136
69MP0006082_CNS_inflammation1.45910718
70MP0002277_abnormal_respiratory_mucosa1.44711450
71MP0001879_abnormal_lymphatic_vessel1.44546431
72MP0002653_abnormal_ependyma_morphology1.44458946
73MP0005389_reproductive_system_phenotype1.43649891
74MP0002429_abnormal_blood_cell1.41224002
75MP0000013_abnormal_adipose_tissue1.40119153
76MP0008775_abnormal_heart_ventricle1.40098693
77MP0010386_abnormal_urinary_bladder1.36844857
78MP0005253_abnormal_eye_physiology1.36743678
79MP0004947_skin_inflammation1.36719080
80MP0010352_gastrointestinal_tract_polyps1.35389612
81MP0001853_heart_inflammation1.35013077
82MP0009046_muscle_twitch1.34408144
83MP0003091_abnormal_cell_migration1.34017028
84MP0009745_abnormal_behavioral_response1.33360357
85MP0001845_abnormal_inflammatory_respons1.30290415
86MP0001485_abnormal_pinna_reflex1.26418530
87MP0000383_abnormal_hair_follicle1.24515290
88MP0000428_abnormal_craniofacial_morphol1.24081332
89MP0005423_abnormal_somatic_nervous1.23722774
90MP0000613_abnormal_salivary_gland1.23479532
91MP0000631_abnormal_neuroendocrine_gland1.23175096
92MP0004510_myositis1.22973821
93MP0002009_preneoplasia1.22829308
94MP0004043_abnormal_pH_regulation1.20868841
95MP0001968_abnormal_touch/_nociception1.20488367
96MP0002693_abnormal_pancreas_physiology1.18825536
97MP0005075_abnormal_melanosome_morpholog1.17576862
98MP0005645_abnormal_hypothalamus_physiol1.17189784
99MP0004270_analgesia1.16354320
100MP0010329_abnormal_lipoprotein_level1.13377246
101MP0002272_abnormal_nervous_system1.13149599
102MP0001984_abnormal_olfaction1.12646822
103MP0010678_abnormal_skin_adnexa1.11976399
104MP0005332_abnormal_amino_acid1.11920984
105MP0008058_abnormal_DNA_repair1.11641132
106MP0006036_abnormal_mitochondrial_physio1.10661495
107MP0010307_abnormal_tumor_latency1.07418303
108MP0003866_abnormal_defecation1.07319018
109MP0000350_abnormal_cell_proliferation1.07255129
110MP0004215_abnormal_myocardial_fiber1.07236464
111MP0003448_altered_tumor_morphology1.07172979
112MP0008877_abnormal_DNA_methylation1.06999583
113MP0000516_abnormal_urinary_system1.06816664
114MP0005367_renal/urinary_system_phenotyp1.06816664
115MP0003077_abnormal_cell_cycle1.06286994
116MP0004133_heterotaxia1.05313570
117MP0002751_abnormal_autonomic_nervous1.03458365
118MP0001533_abnormal_skeleton_physiology1.02382693
119MP0003806_abnormal_nucleotide_metabolis1.02073971
120MP0005310_abnormal_salivary_gland1.01581265
121MP0003252_abnormal_bile_duct0.98262701
122MP0002139_abnormal_hepatobiliary_system0.96586736
123MP0005220_abnormal_exocrine_pancreas0.96530353
124MP0003656_abnormal_erythrocyte_physiolo0.95258338
125MP0004130_abnormal_muscle_cell0.94442852
126MP0000465_gastrointestinal_hemorrhage0.94037456
127MP0003718_maternal_effect0.93949630
128MP0002064_seizures0.93112368
129MP0001944_abnormal_pancreas_morphology0.93003932
130MP0002933_joint_inflammation0.92702289
131MP0003880_abnormal_central_pattern0.90029352
132MP0005448_abnormal_energy_balance0.89750957
133MP0000230_abnormal_systemic_arterial0.88885095
134MP0005636_abnormal_mineral_homeostasis0.86230241
135MP0005666_abnormal_adipose_tissue0.85245041
136MP0008932_abnormal_embryonic_tissue0.85084275
137MP0000858_altered_metastatic_potential0.85070191
138MP0002019_abnormal_tumor_incidence0.84926559
139MP0001919_abnormal_reproductive_system0.83038445
140MP0001851_eye_inflammation0.82658960
141MP0008469_abnormal_protein_level0.82234222
142MP0002734_abnormal_mechanical_nocicepti0.81944818
143MP0001905_abnormal_dopamine_level0.80830938
144MP0008789_abnormal_olfactory_epithelium0.80653759
145MP0003183_abnormal_peptide_metabolism0.80127523
146MP0001765_abnormal_ion_homeostasis0.79994951
147MP0009278_abnormal_bone_marrow0.79824558
148MP0001299_abnormal_eye_distance/0.79713170
149MP0001545_abnormal_hematopoietic_system0.79198700
150MP0005397_hematopoietic_system_phenotyp0.79198700
151MP0003123_paternal_imprinting0.78300607
152MP0002229_neurodegeneration0.77062588
153MP0005174_abnormal_tail_pigmentation0.76306257
154MP0006054_spinal_hemorrhage0.74860733
155MP0000733_abnormal_muscle_development0.74384504
156MP0002282_abnormal_trachea_morphology0.73762425
157MP0003638_abnormal_response/metabolism_0.73521243
158MP0001756_abnormal_urination0.73191133
159MP0003787_abnormal_imprinting0.72547465
160MP0001764_abnormal_homeostasis0.71860706
161MP0000372_irregular_coat_pigmentation0.70798965
162MP0005390_skeleton_phenotype0.69912107
163MP0003984_embryonic_growth_retardation0.69461091
164MP0004197_abnormal_fetal_growth/weight/0.69431065
165MP0003950_abnormal_plasma_membrane0.69142634
166MP0002909_abnormal_adrenal_gland0.68970298
167MP0002095_abnormal_skin_pigmentation0.68786511
168MP0003122_maternal_imprinting0.68627628
169MP0002127_abnormal_cardiovascular_syste0.67986630
170MP0000313_abnormal_cell_death0.67801770
171MP0001873_stomach_inflammation0.67569575
172MP0000490_abnormal_crypts_of0.65878597
173MP0005167_abnormal_blood-brain_barrier0.65618423
174MP0002088_abnormal_embryonic_growth/wei0.65615249
175MP0003111_abnormal_nucleus_morphology0.64916433
176MP0004484_altered_response_of0.64840963
177MP0001529_abnormal_vocalization0.64538466
178MP0006035_abnormal_mitochondrial_morpho0.63778662
179MP0003172_abnormal_lysosome_physiology0.63102149
180MP0005410_abnormal_fertilization0.62472818
181MP0002078_abnormal_glucose_homeostasis0.62305861
182MP0002733_abnormal_thermal_nociception0.62105938
183MP0010234_abnormal_vibrissa_follicle0.61958766
184MP0000003_abnormal_adipose_tissue0.61453320
185MP0000647_abnormal_sebaceous_gland0.61040472
186MP0005058_abnormal_lysosome_morphology0.60307104
187MP0000467_abnormal_esophagus_morphology0.60025543
188MP0003121_genomic_imprinting0.59296417
189MP0002998_abnormal_bone_remodeling0.58223778

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)5.31281716
2Abnormality of the fingertips (HP:0001211)5.18654809
3Hypoplastic pelvis (HP:0008839)4.92351882
4Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.77125247
5Birth length less than 3rd percentile (HP:0003561)4.72748320
6Oligodactyly (hands) (HP:0001180)4.54566890
7Abnormality of lateral ventricle (HP:0030047)4.45667129
8Calcaneovalgus deformity (HP:0001848)4.41623576
9Synostosis involving the elbow (HP:0003938)4.41055104
10Humeroradial synostosis (HP:0003041)4.41055104
11Eosinophilia (HP:0001880)4.20942225
12Diastasis recti (HP:0001540)3.98380645
13Hypothermia (HP:0002045)3.98244638
14Hypoplastic iliac wings (HP:0002866)3.94347625
15Deformed tarsal bones (HP:0008119)3.91319917
16Methylmalonic acidemia (HP:0002912)3.89488638
17Pancreatic cysts (HP:0001737)3.83351204
18Pendular nystagmus (HP:0012043)3.71141650
19Chin dimple (HP:0010751)3.58954330
20Gastrointestinal stroma tumor (HP:0100723)3.55305922
213-Methylglutaconic aciduria (HP:0003535)3.51909183
22Granulocytopenia (HP:0001913)3.50724313
23True hermaphroditism (HP:0010459)3.50499700
24Split foot (HP:0001839)3.49954067
25Pancreatic fibrosis (HP:0100732)3.45523502
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.38979519
27Large hands (HP:0001176)3.26148700
28Abnormality of the calcaneus (HP:0008364)3.24135411
29Abnormality of eosinophils (HP:0001879)3.21137735
30Hepatic necrosis (HP:0002605)3.18070414
31Neoplasm of head and neck (HP:0012288)3.17768575
32Esophageal neoplasm (HP:0100751)3.17768575
33Overlapping toe (HP:0001845)3.05553607
34Oligodactyly (HP:0012165)3.01586228
35Eczematoid dermatitis (HP:0000976)3.00652898
36Abnormality of the renal cortex (HP:0011035)2.99497537
37Methylmalonic aciduria (HP:0012120)2.98516648
38Furrowed tongue (HP:0000221)2.97959214
39Subacute progressive viral hepatitis (HP:0006572)2.96915731
40Conjunctival hamartoma (HP:0100780)2.96194272
41Radial bowing (HP:0002986)2.95431763
42Hepatocellular necrosis (HP:0001404)2.94093470
43Type II lissencephaly (HP:0007260)2.92597295
44Congenital stationary night blindness (HP:0007642)2.90459801
45Leukocytosis (HP:0001974)2.87859928
46Abolished electroretinogram (ERG) (HP:0000550)2.86293545
47Renal cortical cysts (HP:0000803)2.85218860
48Elevated erythrocyte sedimentation rate (HP:0003565)2.79776839
49Chronic hepatic failure (HP:0100626)2.77155615
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77120300
51Large for gestational age (HP:0001520)2.75540431
52Progressive macrocephaly (HP:0004481)2.73189159
53Recurrent bronchitis (HP:0002837)2.72772616
54Acute necrotizing encephalopathy (HP:0006965)2.72631480
55Hamartoma of the eye (HP:0010568)2.68956030
56Increased CSF lactate (HP:0002490)2.68381163
57Pulmonary infiltrates (HP:0002113)2.68097159
58Ketoacidosis (HP:0001993)2.67567573
59Chronic otitis media (HP:0000389)2.67358415
60Mitochondrial inheritance (HP:0001427)2.65702683
61T lymphocytopenia (HP:0005403)2.65525314
62Stomatitis (HP:0010280)2.65282981
63Medial flaring of the eyebrow (HP:0010747)2.65167796
64Gaze-evoked nystagmus (HP:0000640)2.63166444
65Recurrent abscess formation (HP:0002722)2.61494279
66Abnormality of T cell number (HP:0011839)2.60033049
67Adactyly (HP:0009776)2.59446189
68Increased corneal curvature (HP:0100692)2.58116748
69Keratoconus (HP:0000563)2.58116748
70Neoplasm of the peripheral nervous system (HP:0100007)2.56636256
71Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.54084388
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.52294995
73Abnormal mitochondria in muscle tissue (HP:0008316)2.51902487
74Attenuation of retinal blood vessels (HP:0007843)2.49197481
75Hypoplastic ilia (HP:0000946)2.44767919
76Broad ribs (HP:0000885)2.44757811
77Deep philtrum (HP:0002002)2.43687862
78Nephronophthisis (HP:0000090)2.41895616
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.41666606
80Abnormality of midbrain morphology (HP:0002418)2.40663466
81Molar tooth sign on MRI (HP:0002419)2.40663466
82Genetic anticipation (HP:0003743)2.39795276
83Increased cerebral lipofuscin (HP:0011813)2.37438069
84Recurrent bacterial skin infections (HP:0005406)2.36832197
85Hemiparesis (HP:0001269)2.35717024
86Aplasia/Hypoplasia of the fibula (HP:0006492)2.33662858
87Decreased central vision (HP:0007663)2.33058786
88Decreased skull ossification (HP:0004331)2.31961582
89Recurrent viral infections (HP:0004429)2.31838277
90Recurrent fungal infections (HP:0002841)2.30438881
91Progressive cerebellar ataxia (HP:0002073)2.29939265
92Congenital, generalized hypertrichosis (HP:0004540)2.28026854
93Coxa valga (HP:0002673)2.26200031
94Aplasia/hypoplasia of the uterus (HP:0008684)2.26095072
95Abnormality of vitamin B metabolism (HP:0004340)2.24397984
96Long clavicles (HP:0000890)2.23016399
97Hypoglycemic coma (HP:0001325)2.22719543
98Hand muscle atrophy (HP:0009130)2.22240911
99Hyperinsulinemic hypoglycemia (HP:0000825)2.21769256
100Abnormal finger flexion creases (HP:0006143)2.20208335
101Abnormal rod and cone electroretinograms (HP:0008323)2.19452931
102Ketosis (HP:0001946)2.18447483
103Acute encephalopathy (HP:0006846)2.17100657
104Prominent metopic ridge (HP:0005487)2.16309963
105Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14452136
106Abnormality of skull ossification (HP:0002703)2.12714648
107Abnormality of the wing of the ilium (HP:0011867)2.11890776
108Myositis (HP:0100614)2.08804385
109Cystic liver disease (HP:0006706)2.07766151
110Abnormality of the renal medulla (HP:0100957)2.07490082
111Dicarboxylic aciduria (HP:0003215)2.07402535
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07402535
113Aplasia involving forearm bones (HP:0009822)2.07368409
114Absent forearm bone (HP:0003953)2.07368409
115Abnormality of the vitamin B12 metabolism (HP:0004341)2.06472500
116Sclerocornea (HP:0000647)2.05599323
117Confusion (HP:0001289)2.05188607
118Patellar aplasia (HP:0006443)2.05113081
119Progressive inability to walk (HP:0002505)2.04657898
120Agitation (HP:0000713)2.03991367
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02060748
122Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01916049
123Vacuolated lymphocytes (HP:0001922)2.00073810
124Optic nerve hypoplasia (HP:0000609)1.99494107
125Asplenia (HP:0001746)1.98856271
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.96122725
127IgA deficiency (HP:0002720)1.96086640
128Skull defect (HP:0001362)1.95209317
129Cellulitis (HP:0100658)1.94334973
130Bowed forearm bones (HP:0003956)1.93779420
131Bowing of the arm (HP:0006488)1.93779420
132Hypoplasia of the uterus (HP:0000013)1.93038026
133Neoplasm of the rectum (HP:0100743)1.92897927
134Increased serum lactate (HP:0002151)1.92532685
135Prostate neoplasm (HP:0100787)1.92057183
136Genital tract atresia (HP:0001827)1.91435595
137Nephrogenic diabetes insipidus (HP:0009806)1.91195781
138Goiter (HP:0000853)1.89900504
139Congenital primary aphakia (HP:0007707)1.89690302
140Gait imbalance (HP:0002141)1.88027277
141Slender long bone (HP:0003100)1.87787093
142Thyroiditis (HP:0100646)1.86767768
143Broad-based gait (HP:0002136)1.86558742
144Calf muscle hypertrophy (HP:0008981)1.85792212
145Absent thumb (HP:0009777)1.84493957
146Viral hepatitis (HP:0006562)1.84347348
147Broad thumb (HP:0011304)1.84082800
148Hyperventilation (HP:0002883)1.83885250
149Vaginal atresia (HP:0000148)1.83791469
150Aplasia/Hypoplasia of the patella (HP:0006498)1.83705064
151Neoplasm of the small intestine (HP:0100833)1.82280116
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.81509789
153Mediastinal lymphadenopathy (HP:0100721)1.80851550
154Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.80352552
155Male pseudohermaphroditism (HP:0000037)1.79641816
156IgM deficiency (HP:0002850)1.78837446
157Inability to walk (HP:0002540)1.78680406
158Sandal gap (HP:0001852)1.77565536
159Respiratory failure (HP:0002878)1.77053787
160Abnormality of the humeroradial joint (HP:0100744)1.76394937
161Symphalangism affecting the phalanges of the hand (HP:0009773)1.76049530
162Hypoplastic toenails (HP:0001800)1.75894249
163Severe visual impairment (HP:0001141)1.75158865
164Progressive microcephaly (HP:0000253)1.75145493
165Neoplasm of the adrenal cortex (HP:0100641)1.75077803
166Muscle hypertrophy of the lower extremities (HP:0008968)1.75007197
167Lethargy (HP:0001254)1.74993013
168Congenital sensorineural hearing impairment (HP:0008527)1.74564613
169Barrel-shaped chest (HP:0001552)1.73329619
170Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72791926
171Pachygyria (HP:0001302)1.72688941
172Optic disc pallor (HP:0000543)1.71761970
173Abnormality of T cells (HP:0002843)1.71704219
174Limited elbow extension (HP:0001377)1.71177239
175Interstitial pulmonary disease (HP:0006530)1.70789470
176Abnormality of the metopic suture (HP:0005556)1.70229703
177Type I transferrin isoform profile (HP:0003642)1.69452567
178Abnormal protein glycosylation (HP:0012346)1.68831799
179Abnormal glycosylation (HP:0012345)1.68831799
180Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68831799
181Abnormal protein N-linked glycosylation (HP:0012347)1.68831799
182IgG deficiency (HP:0004315)1.68785300
183Retrobulbar optic neuritis (HP:0100654)1.67267200
184Optic neuritis (HP:0100653)1.67267200
185Hypoalbuminemia (HP:0003073)1.67059103
186Abnormal albumin level (HP:0012116)1.67059103
187Micronodular cirrhosis (HP:0001413)1.66219440
188Somatic mutation (HP:0001428)1.66163478
189Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65996112
190Severe muscular hypotonia (HP:0006829)1.65965861
191Acrocyanosis (HP:0001063)1.65784780
192Absent speech (HP:0001344)1.65714693
193Orchitis (HP:0100796)1.64419166
194Fetal akinesia sequence (HP:0001989)1.63886923
195Tubulointerstitial nephritis (HP:0001970)1.62281063
196Abnormality of the nasal septum (HP:0000419)1.61711885
197Broad phalanges of the hand (HP:0009768)1.61481580
198Bone cyst (HP:0012062)1.60578423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.77388874
2BMPR1B5.05724524
3MAP4K13.61523529
4PTK63.55536057
5GRK13.07463318
6SIK33.06976513
7PDGFRA3.02732857
8MAP4K22.91789286
9JAK32.85136319
10NME12.71998549
11BLK2.71721044
12SIK12.71578664
13TXK2.57362385
14MST42.53809349
15SIK22.53796256
16ADRBK22.49423084
17PASK2.48903842
18MARK32.36673698
19TSSK62.26873668
20VRK22.15600936
21EEF2K2.14843942
22TYK22.10438387
23BTK1.99343140
24PLK21.96394767
25TRIM281.91946594
26PHKG21.83029699
27PHKG11.83029699
28FGR1.77892955
29JAK21.74507898
30GRK61.73905560
31WNK31.65667136
32ZAP701.65490826
33EPHA31.62194103
34EIF2AK11.60608317
35KIT1.55250594
36SRPK11.52818028
37VRK11.51583595
38RAF11.49963651
39RIPK41.47538952
40PDGFRB1.46885908
41FGFR21.46881557
42MAP3K141.46578238
43LCK1.43664641
44LYN1.41155945
45FGFR41.40665215
46TEC1.39048925
47MAPK131.37394478
48CAMKK11.37354058
49BCR1.36741839
50ITK1.34067700
51EIF2AK31.32629143
52MAPKAPK31.31722813
53PINK11.27199693
54PRKD21.25555055
55TAF11.25472116
56OBSCN1.25058462
57TAOK31.23681402
58SYK1.22483859
59DAPK21.21943742
60STK101.20826786
61FLT31.20344328
62CSF1R1.17943375
63BCKDK1.16773014
64PRKCQ1.15965798
65HCK1.14101636
66CSNK1G31.13864066
67TBK11.10879979
68PAK31.09461348
69TGFBR21.08654658
70PTK2B1.07391368
71WNK41.04418206
72MAP3K121.04317046
73NEK61.03993504
74CDK81.03634855
75CHUK1.02818335
76PLK31.01501233
77BUB11.00274223
78EPHB11.00162523
79NUAK11.00123201
80CSNK1G20.98040859
81PDK20.97923127
82JAK10.97787714
83CSNK1A1L0.96401735
84PIM10.95114060
85MKNK10.94625366
86DYRK20.93558530
87PRKCE0.90839774
88IRAK40.89678804
89CSNK1G10.89128559
90IKBKB0.87910964
91MAP3K40.87711072
92MUSK0.87460776
93PAK60.84790523
94MAP3K90.83176344
95ZAK0.82798608
96CLK10.82789124
97ATR0.78783486
98OXSR10.77406190
99IRAK10.76336983
100RPS6KB20.74867627
101CHEK10.74696231
102IRAK30.74395143
103MAP3K70.74161771
104MAP3K100.73837847
105INSRR0.70750975
106IKBKE0.69444245
107ADRBK10.69205048
108FER0.67427107
109KSR10.64862495
110MAPKAPK50.63185256
111PRKCG0.63073186
112BMX0.63048958
113CSK0.62780301
114PIK3CA0.62630162
115ACVR1B0.62431515
116FGFR30.61387885
117NLK0.61070710
118CDK90.60642903
119RIPK10.60624024
120FES0.59864368
121CASK0.59275909
122MAP2K70.57661180
123PKN20.57486007
124PRKAA20.54862067
125MKNK20.54656360
126CDK120.54096050
127GRK70.53459760
128ERN10.51893235
129BRD40.50106906
130CSNK1A10.49988627
131HIPK20.48702598
132CSNK1D0.48257361
133EGFR0.47834066
134TRPM70.45685153
135STK390.45602238
136GRK50.44389446
137MAP3K30.43423407
138SCYL20.42871696
139PRKAA10.41377173
140ERBB30.40328511
141EPHA20.39457717
142CDC70.39155371
143ALK0.38628020
144IGF1R0.38610086
145STK160.38512364
146CDK20.37174046
147TTN0.36977574
148CDK40.36514323
149PRKACA0.36288268
150PRKCI0.34704292
151MATK0.34691487
152CDK10.34182402
153EIF2AK20.33722328
154PRKCZ0.33186146
155ABL10.32776097
156DMPK0.32577834
157RPS6KA40.31134365
158TLK10.30655805
159TGFBR10.30374370
160CAMKK20.30180575
161PRKD10.30066360
162DAPK10.29908141
163BMPR20.29584358
164MAPK70.28757681
165AKT30.28096957
166MAPK140.27811382
167MTOR0.27398194
168WNK10.27278927
169AKT10.27073022
170PIM20.26435859
171STK110.26276259
172RPS6KA50.26053684

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.47143861
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.11541936
3Oxidative phosphorylation_Homo sapiens_hsa001902.90395544
4Protein export_Homo sapiens_hsa030602.85998750
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.83113485
6Measles_Homo sapiens_hsa051622.54492892
7Phototransduction_Homo sapiens_hsa047442.51845515
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21360876
9T cell receptor signaling pathway_Homo sapiens_hsa046602.20700080
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20474088
11B cell receptor signaling pathway_Homo sapiens_hsa046622.20221132
12Selenocompound metabolism_Homo sapiens_hsa004502.19648879
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18858356
14Regulation of autophagy_Homo sapiens_hsa041402.17999437
15Primary immunodeficiency_Homo sapiens_hsa053402.08202529
16Tryptophan metabolism_Homo sapiens_hsa003802.04930123
17Osteoclast differentiation_Homo sapiens_hsa043802.01832898
18Sulfur metabolism_Homo sapiens_hsa009202.01711526
19Leishmaniasis_Homo sapiens_hsa051402.01229213
20Legionellosis_Homo sapiens_hsa051342.00361613
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99541784
22Butanoate metabolism_Homo sapiens_hsa006501.92433265
23Parkinsons disease_Homo sapiens_hsa050121.91134298
24Collecting duct acid secretion_Homo sapiens_hsa049661.83086540
25RNA polymerase_Homo sapiens_hsa030201.80610311
26Proteasome_Homo sapiens_hsa030501.74259091
27Fatty acid elongation_Homo sapiens_hsa000621.66482351
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65558896
29Homologous recombination_Homo sapiens_hsa034401.61417272
30Antigen processing and presentation_Homo sapiens_hsa046121.57742848
31Basal transcription factors_Homo sapiens_hsa030221.56925946
32Allograft rejection_Homo sapiens_hsa053301.55839888
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53566036
34Chronic myeloid leukemia_Homo sapiens_hsa052201.53121146
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48776883
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48621716
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48253609
38Type I diabetes mellitus_Homo sapiens_hsa049401.47409184
39RNA degradation_Homo sapiens_hsa030181.46971725
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45883523
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41654586
42Nitrogen metabolism_Homo sapiens_hsa009101.41360459
43Herpes simplex infection_Homo sapiens_hsa051681.40690057
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40422364
45Hepatitis B_Homo sapiens_hsa051611.38442348
46Influenza A_Homo sapiens_hsa051641.37676229
47Glioma_Homo sapiens_hsa052141.37630233
48Cardiac muscle contraction_Homo sapiens_hsa042601.36490015
49Acute myeloid leukemia_Homo sapiens_hsa052211.36404947
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35574585
51Insulin secretion_Homo sapiens_hsa049111.33748930
52Graft-versus-host disease_Homo sapiens_hsa053321.33605380
53Propanoate metabolism_Homo sapiens_hsa006401.33467112
54Peroxisome_Homo sapiens_hsa041461.33319940
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.32937032
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31649907
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.29953313
58Prolactin signaling pathway_Homo sapiens_hsa049171.29589622
59Toxoplasmosis_Homo sapiens_hsa051451.28230060
60Hematopoietic cell lineage_Homo sapiens_hsa046401.27124947
61MicroRNAs in cancer_Homo sapiens_hsa052061.27002485
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26922922
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25974627
64Spliceosome_Homo sapiens_hsa030401.25720414
65Alzheimers disease_Homo sapiens_hsa050101.25661212
66Apoptosis_Homo sapiens_hsa042101.21098567
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21054742
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19552103
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19202532
70TNF signaling pathway_Homo sapiens_hsa046681.17826552
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17307199
72DNA replication_Homo sapiens_hsa030301.15634701
73Circadian rhythm_Homo sapiens_hsa047101.15318910
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13393175
75Chemokine signaling pathway_Homo sapiens_hsa040621.10422641
76Linoleic acid metabolism_Homo sapiens_hsa005911.09116266
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08221904
78HTLV-I infection_Homo sapiens_hsa051661.08066893
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07175431
80Viral carcinogenesis_Homo sapiens_hsa052031.06846698
81Pertussis_Homo sapiens_hsa051331.06183539
82Tuberculosis_Homo sapiens_hsa051521.06149395
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06131804
84Huntingtons disease_Homo sapiens_hsa050161.04431716
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02266500
86Nicotine addiction_Homo sapiens_hsa050331.01039018
87Fatty acid degradation_Homo sapiens_hsa000711.00874291
88Epstein-Barr virus infection_Homo sapiens_hsa051690.99896057
89Chemical carcinogenesis_Homo sapiens_hsa052040.99640683
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.99193981
91Fatty acid metabolism_Homo sapiens_hsa012120.98812677
92Fanconi anemia pathway_Homo sapiens_hsa034600.98085970
93Non-homologous end-joining_Homo sapiens_hsa034500.96073937
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95359502
95Caffeine metabolism_Homo sapiens_hsa002320.93272410
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.92619946
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91767935
98Ether lipid metabolism_Homo sapiens_hsa005650.90566796
99Staphylococcus aureus infection_Homo sapiens_hsa051500.89618582
100Non-small cell lung cancer_Homo sapiens_hsa052230.88607572
101Hepatitis C_Homo sapiens_hsa051600.87733358
102Taste transduction_Homo sapiens_hsa047420.85562746
103Mismatch repair_Homo sapiens_hsa034300.85544961
104Pancreatic cancer_Homo sapiens_hsa052120.84987190
105Colorectal cancer_Homo sapiens_hsa052100.84428480
106VEGF signaling pathway_Homo sapiens_hsa043700.84185669
107Viral myocarditis_Homo sapiens_hsa054160.83880805
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82452193
109ABC transporters_Homo sapiens_hsa020100.82243419
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81542073
111FoxO signaling pathway_Homo sapiens_hsa040680.79532882
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.78271296
113Vitamin digestion and absorption_Homo sapiens_hsa049770.77467265
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76838616
115Cell cycle_Homo sapiens_hsa041100.76505796
116Type II diabetes mellitus_Homo sapiens_hsa049300.76490219
117Autoimmune thyroid disease_Homo sapiens_hsa053200.76402952
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76375568
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75919535
120beta-Alanine metabolism_Homo sapiens_hsa004100.75881584
121Malaria_Homo sapiens_hsa051440.74621026
122Platelet activation_Homo sapiens_hsa046110.74226270
123Notch signaling pathway_Homo sapiens_hsa043300.73009990
124Base excision repair_Homo sapiens_hsa034100.72002662
125Prostate cancer_Homo sapiens_hsa052150.71949647
126One carbon pool by folate_Homo sapiens_hsa006700.71227121
127HIF-1 signaling pathway_Homo sapiens_hsa040660.70712274
128Asthma_Homo sapiens_hsa053100.70573952
129Synaptic vesicle cycle_Homo sapiens_hsa047210.69473781
130Small cell lung cancer_Homo sapiens_hsa052220.69321635
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69150839
132Endometrial cancer_Homo sapiens_hsa052130.68976642
133Amoebiasis_Homo sapiens_hsa051460.68099321
134p53 signaling pathway_Homo sapiens_hsa041150.67412874
135Rheumatoid arthritis_Homo sapiens_hsa053230.66607967
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66054626
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65531797
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64946001
139African trypanosomiasis_Homo sapiens_hsa051430.64377152
140Insulin resistance_Homo sapiens_hsa049310.64278177
141Mineral absorption_Homo sapiens_hsa049780.62888353
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62851008
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62386388
144MAPK signaling pathway_Homo sapiens_hsa040100.61884742
145Proteoglycans in cancer_Homo sapiens_hsa052050.60752246
146Systemic lupus erythematosus_Homo sapiens_hsa053220.60033021
147Glycerolipid metabolism_Homo sapiens_hsa005610.59770233
148Phagosome_Homo sapiens_hsa041450.59226497
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.57347882
150Retinol metabolism_Homo sapiens_hsa008300.57106276
151Melanoma_Homo sapiens_hsa052180.57087729
152Purine metabolism_Homo sapiens_hsa002300.56877348
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.56556105
154Inositol phosphate metabolism_Homo sapiens_hsa005620.55314278
155mRNA surveillance pathway_Homo sapiens_hsa030150.54717343
156ErbB signaling pathway_Homo sapiens_hsa040120.54411203
157Lysosome_Homo sapiens_hsa041420.54401501
158Metabolic pathways_Homo sapiens_hsa011000.54238038
159Renin secretion_Homo sapiens_hsa049240.54161592
160RNA transport_Homo sapiens_hsa030130.52805234
161Shigellosis_Homo sapiens_hsa051310.52778645
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52302040
163Renal cell carcinoma_Homo sapiens_hsa052110.51955125
164Salmonella infection_Homo sapiens_hsa051320.50666486
165Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50664259
166GABAergic synapse_Homo sapiens_hsa047270.50229648
167Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49016956
168Serotonergic synapse_Homo sapiens_hsa047260.48306302
169Morphine addiction_Homo sapiens_hsa050320.48265049
170Dorso-ventral axis formation_Homo sapiens_hsa043200.45504529
171Nucleotide excision repair_Homo sapiens_hsa034200.44480725
172Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44471338
173Fat digestion and absorption_Homo sapiens_hsa049750.43321205
174Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38551670
175Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35980929
176Steroid biosynthesis_Homo sapiens_hsa001000.33515842
177Salivary secretion_Homo sapiens_hsa049700.33515099
178Calcium signaling pathway_Homo sapiens_hsa040200.32776004
179Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32178717
180Ovarian steroidogenesis_Homo sapiens_hsa049130.31846844
181Amphetamine addiction_Homo sapiens_hsa050310.31707519
182Dopaminergic synapse_Homo sapiens_hsa047280.31634964
183Histidine metabolism_Homo sapiens_hsa003400.31197751
184Olfactory transduction_Homo sapiens_hsa047400.26040588
185Starch and sucrose metabolism_Homo sapiens_hsa005000.25137125

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