ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	6.42604683
2	regulation of cilium movement (GO:0003352)	6.40030565
3	response to pheromone (GO:0019236)	6.25882753
4	rRNA methylation (GO:0031167)	6.24917521
5	acrosome reaction (GO:0007340)	5.59765090
6	rRNA modification (GO:0000154)	5.57720017
7	DNA deamination (GO:0045006)	5.23008191
8	fusion of sperm to egg plasma membrane (GO:0007342)	5.17635683
9	cellular ketone body metabolic process (GO:0046950)	5.06614098
10	axoneme assembly (GO:0035082)	4.67251567
11	ketone body metabolic process (GO:1902224)	4.45650284
12	multicellular organism reproduction (GO:0032504)	4.45081591
13	sperm-egg recognition (GO:0035036)	4.34422033
14	brain morphogenesis (GO:0048854)	4.15107252
15	plasma membrane fusion (GO:0045026)	4.10262232
16	nonmotile primary cilium assembly (GO:0035058)	3.98259176
17	spermatid development (GO:0007286)	3.97496953
18	sperm capacitation (GO:0048240)	3.86040672
19	reproduction (GO:0000003)	3.84850302
20	single strand break repair (GO:0000012)	3.84702591
21	negative regulation of multicellular organism growth (GO:0040015)	3.84177494
22	signal peptide processing (GO:0006465)	3.81797643
23	cellular response to exogenous dsRNA (GO:0071360)	3.80941331
24	regulation of microtubule-based movement (GO:0060632)	3.79655363
25	cell-cell recognition (GO:0009988)	3.73084828
26	protein polyglutamylation (GO:0018095)	3.72484585
27	piRNA metabolic process (GO:0034587)	3.72017860
28	spermatid nucleus differentiation (GO:0007289)	3.65396024
29	coenzyme catabolic process (GO:0009109)	3.60365653
30	binding of sperm to zona pellucida (GO:0007339)	3.55910039
31	microtubule depolymerization (GO:0007019)	3.55820244
32	centriole replication (GO:0007099)	3.53615611
33	RNA destabilization (GO:0050779)	3.47717271
34	cytidine deamination (GO:0009972)	3.42929976
35	cytidine metabolic process (GO:0046087)	3.42929976
36	cytidine catabolic process (GO:0006216)	3.42929976
37	microtubule polymerization or depolymerization (GO:0031109)	3.37905536
38	indole-containing compound catabolic process (GO:0042436)	3.37222771
39	indolalkylamine catabolic process (GO:0046218)	3.37222771
40	tryptophan catabolic process (GO:0006569)	3.37222771
41	establishment of protein localization to Golgi (GO:0072600)	3.33384825
42	glycerol ether metabolic process (GO:0006662)	3.31979132
43	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.29068142
44	protein targeting to Golgi (GO:0000042)	3.19582819
45	tryptophan metabolic process (GO:0006568)	3.19477324
46	kynurenine metabolic process (GO:0070189)	3.18330225
47	negative regulation of response to food (GO:0032096)	3.16550787
48	negative regulation of appetite (GO:0032099)	3.16550787
49	single fertilization (GO:0007338)	3.14733632
50	cellular response to leptin stimulus (GO:0044320)	3.11866704
51	regulation of centriole replication (GO:0046599)	3.11389251
52	indolalkylamine metabolic process (GO:0006586)	3.09594455
53	DNA methylation involved in gamete generation (GO:0043046)	3.06249096
54	ether metabolic process (GO:0018904)	3.05579413
55	artery smooth muscle contraction (GO:0014824)	3.05565779
56	reciprocal meiotic recombination (GO:0007131)	3.00293630
57	reciprocal DNA recombination (GO:0035825)	3.00293630
58	spermatogenesis (GO:0007283)	2.97886448
59	male gamete generation (GO:0048232)	2.96948676
60	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.96065866
61	epithelial cilium movement (GO:0003351)	2.91744589
62	cilium morphogenesis (GO:0060271)	2.91473808
63	phosphatidylethanolamine metabolic process (GO:0046337)	2.91057971
64	microtubule severing (GO:0051013)	2.86134221
65	photoreceptor cell maintenance (GO:0045494)	2.85722881
66	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.83008864
67	neuronal action potential propagation (GO:0019227)	2.78787247
68	cullin deneddylation (GO:0010388)	2.78575523
69	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.77643662
70	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.77423051
71	gamete generation (GO:0007276)	2.75736648
72	tonic smooth muscle contraction (GO:0014820)	2.74414088
73	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.73832474
74	NAD biosynthetic process (GO:0009435)	2.72950217
75	calcium ion-dependent exocytosis (GO:0017156)	2.72243732
76	purine-containing compound salvage (GO:0043101)	2.70314105
77	serotonin receptor signaling pathway (GO:0007210)	2.68369081
78	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.68175870
79	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.68133116
80	ATP synthesis coupled proton transport (GO:0015986)	2.68133116
81	axonemal dynein complex assembly (GO:0070286)	2.67554543
82	sulfation (GO:0051923)	2.67144045
83	platelet dense granule organization (GO:0060155)	2.67066230
84	regulation of interleukin-13 production (GO:0032656)	2.63731131
85	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.63724931
86	L-fucose catabolic process (GO:0042355)	2.61296434
87	fucose catabolic process (GO:0019317)	2.61296434
88	L-fucose metabolic process (GO:0042354)	2.61296434
89	cofactor catabolic process (GO:0051187)	2.60345781
90	cilium organization (GO:0044782)	2.56317261
91	male meiosis I (GO:0007141)	2.55256781
92	organic cation transport (GO:0015695)	2.54958760
93	regulation of penile erection (GO:0060405)	2.51511893
94	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.51084458
95	centriole assembly (GO:0098534)	2.50943530
96	proteasome assembly (GO:0043248)	2.48364772
97	fertilization (GO:0009566)	2.48140400
98	nucleotide transmembrane transport (GO:1901679)	2.47438255
99	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.45895890
100	ovulation cycle (GO:0042698)	2.45701549

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.31668803
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99724746
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89689226
4	VDR_22108803_ChIP-Seq_LS180_Human	2.88820112
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40828453
6	ER_23166858_ChIP-Seq_MCF-7_Human	2.38313461
7	FUS_26573619_Chip-Seq_HEK293_Human	2.33213275
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15560179
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11935164
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11392589
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.09497952
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02867713
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00717267
14	CBP_20019798_ChIP-Seq_JUKART_Human	1.99140292
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.99140292
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.93999467
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.92353306
18	P300_19829295_ChIP-Seq_ESCs_Human	1.88594943
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87283038
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.86609659
21	SOX2_19829295_ChIP-Seq_ESCs_Human	1.83698452
22	NANOG_19829295_ChIP-Seq_ESCs_Human	1.83698452
23	EWS_26573619_Chip-Seq_HEK293_Human	1.82979727
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80102182
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79691921
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78853500
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77545812
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.77419531
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76670872
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.74433882
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.67750157
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60771717
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.60110319
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58927991
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.55714244
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53891718
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51619918
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51619918
39	AR_25329375_ChIP-Seq_VCAP_Human	1.43327501
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41524040
41	NCOR_22424771_ChIP-Seq_293T_Human	1.40504116
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40141618
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39987880
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39429250
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38841319
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37067770
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36927954
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36292887
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35326125
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35326125
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34791695
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34392088
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33858555
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.32610075
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.31769555
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.31069995
57	STAT3_23295773_ChIP-Seq_U87_Human	1.30901856
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30241181
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.30156853
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29751826
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.29722810
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29636427
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29536803
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29476332
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.29364588
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28920517
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27974780
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26004555
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.25862503
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23679703
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21704056
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.21685377
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20875084
74	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20534226
75	AR_20517297_ChIP-Seq_VCAP_Human	1.18592526
76	GATA3_26560356_Chip-Seq_TH2_Human	1.16365942
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14260587
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14042371
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14011848
80	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13928604
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.13745877
82	CEBPB_22108803_ChIP-Seq_LS180_Human	1.13116760
83	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12791247
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12421239
85	OCT4_20526341_ChIP-Seq_ESCs_Human	1.12193568
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.12087424
87	ERA_21632823_ChIP-Seq_H3396_Human	1.10196641
88	TCF4_23295773_ChIP-Seq_U87_Human	1.09772256
89	RUNX_20019798_ChIP-Seq_JUKART_Human	1.09425071
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09420035
91	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08996439
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08991847
93	EZH2_22144423_ChIP-Seq_EOC_Human	1.08439535
94	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07626526
95	PHF8_20622853_ChIP-Seq_HELA_Human	1.06259231
96	ERG_20517297_ChIP-Seq_VCAP_Human	1.05391341
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05390606
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05267871
99	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03813667
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03781524

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.34432335
2	MP0001984_abnormal_olfaction	3.20663537
3	MP0000569_abnormal_digit_pigmentation	2.87068797
4	MP0002736_abnormal_nociception_after	2.65287967
5	MP0001968_abnormal_touch/_nociception	2.62326903
6	MP0003878_abnormal_ear_physiology	2.45565690
7	MP0005377_hearing/vestibular/ear_phenot	2.45565690
8	MP0003880_abnormal_central_pattern	2.34631659
9	MP0003011_delayed_dark_adaptation	2.34068885
10	MP0005379_endocrine/exocrine_gland_phen	2.23811860
11	MP0003718_maternal_effect	2.08338216
12	MP0005551_abnormal_eye_electrophysiolog	2.06219780
13	MP0003698_abnormal_male_reproductive	2.03778931
14	MP0008875_abnormal_xenobiotic_pharmacok	2.00747554
15	MP0001929_abnormal_gametogenesis	1.96327594
16	MP0004381_abnormal_hair_follicle	1.85904295
17	MP0003252_abnormal_bile_duct	1.85849569
18	MP0001986_abnormal_taste_sensitivity	1.82123881
19	MP0005310_abnormal_salivary_gland	1.68191500
20	MP0004742_abnormal_vestibular_system	1.66784289
21	MP0005365_abnormal_bile_salt	1.62371792
22	MP0005671_abnormal_response_to	1.59567968
23	MP0009697_abnormal_copulation	1.59490034
24	MP0002163_abnormal_gland_morphology	1.58582026
25	MP0008872_abnormal_physiological_respon	1.57102782
26	MP0002138_abnormal_hepatobiliary_system	1.52705652
27	MP0002928_abnormal_bile_duct	1.48455468
28	MP0002272_abnormal_nervous_system	1.45058727
29	MP0000427_abnormal_hair_cycle	1.43882015
30	MP0008877_abnormal_DNA_methylation	1.41870521
31	MP0005075_abnormal_melanosome_morpholog	1.41614115
32	MP0005423_abnormal_somatic_nervous	1.40873389
33	MP0005253_abnormal_eye_physiology	1.40276561
34	MP0002876_abnormal_thyroid_physiology	1.36562322
35	MP0001790_abnormal_immune_system	1.36514878
36	MP0005387_immune_system_phenotype	1.36514878
37	MP0003646_muscle_fatigue	1.30215119
38	MP0002234_abnormal_pharynx_morphology	1.29346279
39	MP0005085_abnormal_gallbladder_physiolo	1.29190893
40	MP0009745_abnormal_behavioral_response	1.28402425
41	MP0002127_abnormal_cardiovascular_syste	1.27011880
42	MP0006072_abnormal_retinal_apoptosis	1.26180839
43	MP0002733_abnormal_thermal_nociception	1.25933958
44	MP0000013_abnormal_adipose_tissue	1.24674619
45	MP0002132_abnormal_respiratory_system	1.23855880
46	MP0001970_abnormal_pain_threshold	1.23756352
47	MP0002160_abnormal_reproductive_system	1.23391358
48	MP0002006_tumorigenesis	1.22796092
49	MP0005084_abnormal_gallbladder_morpholo	1.20801644
50	MP0000372_irregular_coat_pigmentation	1.20195632
51	MP0002166_altered_tumor_susceptibility	1.20001679
52	MP0001485_abnormal_pinna_reflex	1.18956680
53	MP0001486_abnormal_startle_reflex	1.18458659
54	MP0005645_abnormal_hypothalamus_physiol	1.17887051
55	MP0008058_abnormal_DNA_repair	1.16999205
56	MP0002734_abnormal_mechanical_nocicepti	1.15877354
57	MP0001800_abnormal_humoral_immune	1.13867672
58	MP0005083_abnormal_biliary_tract	1.13460495
59	MP0001835_abnormal_antigen_presentation	1.10944764
60	MP0008775_abnormal_heart_ventricle	1.10385271
61	MP0005389_reproductive_system_phenotype	1.04280639
62	MP0000685_abnormal_immune_system	1.03775381
63	MP0003638_abnormal_response/metabolism_	1.02296925
64	MP0005636_abnormal_mineral_homeostasis	1.02206313
65	MP0001348_abnormal_lacrimal_gland	1.00095432
66	MP0009764_decreased_sensitivity_to	0.99130597
67	MP0006035_abnormal_mitochondrial_morpho	0.98123587
68	MP0002161_abnormal_fertility/fecundity	0.97725664
69	MP0001905_abnormal_dopamine_level	0.97577308
70	MP0005670_abnormal_white_adipose	0.96874992
71	MP0003136_yellow_coat_color	0.96068502
72	MP0006276_abnormal_autonomic_nervous	0.94497481
73	MP0005167_abnormal_blood-brain_barrier	0.93853469
74	MP0002210_abnormal_sex_determination	0.93390615
75	MP0000653_abnormal_sex_gland	0.91704933
76	MP0000015_abnormal_ear_pigmentation	0.91281995
77	MP0006036_abnormal_mitochondrial_physio	0.90222850
78	MP0001963_abnormal_hearing_physiology	0.89546037
79	MP0008995_early_reproductive_senescence	0.89381096
80	MP0004215_abnormal_myocardial_fiber	0.88527407
81	MP0004145_abnormal_muscle_electrophysio	0.88054242
82	MP0004885_abnormal_endolymph	0.86249567
83	MP0001501_abnormal_sleep_pattern	0.84975209
84	MP0001145_abnormal_male_reproductive	0.84447922
85	MP0004142_abnormal_muscle_tone	0.84302144
86	MP0005164_abnormal_response_to	0.84099998
87	MP0003724_increased_susceptibility_to	0.83943151
88	MP0005503_abnormal_tendon_morphology	0.82842106
89	MP0009785_altered_susceptibility_to	0.81679604
90	MP0000516_abnormal_urinary_system	0.80373024
91	MP0005367_renal/urinary_system_phenotyp	0.80373024
92	MP0005174_abnormal_tail_pigmentation	0.80022542
93	MP0002572_abnormal_emotion/affect_behav	0.79262634
94	MP0001765_abnormal_ion_homeostasis	0.78554770
95	MP0005646_abnormal_pituitary_gland	0.76590100
96	MP0002938_white_spotting	0.76506422
97	MP0009046_muscle_twitch	0.75873963
98	MP0002452_abnormal_antigen_presenting	0.75584510
99	MP0000026_abnormal_inner_ear	0.74642866
100	MP0002723_abnormal_immune_serum	0.74042736

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.72965698
2	Medial flaring of the eyebrow (HP:0010747)	4.16895897
3	Pancreatic cysts (HP:0001737)	4.09011227
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.89187434
5	Nephrogenic diabetes insipidus (HP:0009806)	3.72303276
6	Congenital primary aphakia (HP:0007707)	3.69947275
7	Gait imbalance (HP:0002141)	3.60240554
8	Pancreatic fibrosis (HP:0100732)	3.37373997
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.21765515
10	Congenital stationary night blindness (HP:0007642)	3.03122186
11	Constricted visual fields (HP:0001133)	2.98724452
12	True hermaphroditism (HP:0010459)	2.89216470
13	Poor coordination (HP:0002370)	2.86767841
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.86716327
15	Absent/shortened dynein arms (HP:0200106)	2.78379999
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78379999
17	Vaginal atresia (HP:0000148)	2.77384135
18	Genital tract atresia (HP:0001827)	2.75927873
19	Abnormality of the renal cortex (HP:0011035)	2.75245958
20	Cone-rod dystrophy (HP:0000548)	2.75216869
21	Abnormality of macular pigmentation (HP:0008002)	2.69264995
22	Eosinophilia (HP:0001880)	2.68846722
23	Nephronophthisis (HP:0000090)	2.67219557
24	Abnormal respiratory motile cilium physiology (HP:0012261)	2.65276276
25	Abnormality of the renal medulla (HP:0100957)	2.53457179
26	Tubulointerstitial nephritis (HP:0001970)	2.50151974
27	Severe visual impairment (HP:0001141)	2.50022349
28	Chronic bronchitis (HP:0004469)	2.49987988
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.49736073
30	Hypoproteinemia (HP:0003075)	2.47372173
31	Type II lissencephaly (HP:0007260)	2.44765924
32	Hypomagnesemia (HP:0002917)	2.41053031
33	Abnormality of alanine metabolism (HP:0010916)	2.40954670
34	Hyperalaninemia (HP:0003348)	2.40954670
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40954670
36	Polyuria (HP:0000103)	2.38258995
37	Abnormality of DNA repair (HP:0003254)	2.35638673
38	Decreased central vision (HP:0007663)	2.35249591
39	Congenital, generalized hypertrichosis (HP:0004540)	2.34425431
40	Generalized aminoaciduria (HP:0002909)	2.30033930
41	Metabolic alkalosis (HP:0200114)	2.28847947
42	Rhinitis (HP:0012384)	2.27436573
43	Tubulointerstitial abnormality (HP:0001969)	2.24295141
44	Thyroid-stimulating hormone excess (HP:0002925)	2.23644769
45	Optic disc pallor (HP:0000543)	2.22471464
46	Abnormal urine output (HP:0012590)	2.19574319
47	Cystic liver disease (HP:0006706)	2.19119970
48	Tetany (HP:0001281)	2.18135911
49	Abnormality of the ileum (HP:0001549)	2.17812476
50	Congenital sensorineural hearing impairment (HP:0008527)	2.17778610
51	Meckel diverticulum (HP:0002245)	2.17154135
52	Astigmatism (HP:0000483)	2.16708664
53	Hemiplegia (HP:0002301)	2.15466413
54	IgG deficiency (HP:0004315)	2.14142518
55	Increased IgM level (HP:0003496)	2.13973361
56	Central scotoma (HP:0000603)	2.13214783
57	Confusion (HP:0001289)	2.12919778
58	Aplasia/Hypoplasia of the lens (HP:0008063)	2.11446245
59	Large for gestational age (HP:0001520)	2.10039352
60	Abnormal spermatogenesis (HP:0008669)	2.09543677
61	Hypothermia (HP:0002045)	2.09154308
62	Delayed CNS myelination (HP:0002188)	2.06915507
63	Congenital hepatic fibrosis (HP:0002612)	2.06716382
64	Prominent supraorbital ridges (HP:0000336)	2.06563823
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04774412
66	Azoospermia (HP:0000027)	2.03972115
67	Inability to walk (HP:0002540)	2.03701236
68	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01411140
69	Hypokalemic alkalosis (HP:0001949)	1.98487749
70	Abnormality of eosinophils (HP:0001879)	1.98169980
71	Scotoma (HP:0000575)	1.94647038
72	Enlarged epiphyses (HP:0010580)	1.94498484
73	Progressive cerebellar ataxia (HP:0002073)	1.90297857
74	Abolished electroretinogram (ERG) (HP:0000550)	1.90281947
75	Cerebellar dysplasia (HP:0007033)	1.90272687
76	Abnormal ciliary motility (HP:0012262)	1.89748590
77	Granulocytopenia (HP:0001913)	1.89363746
78	Colon cancer (HP:0003003)	1.88835140
79	Autoimmune thrombocytopenia (HP:0001973)	1.88826662
80	Abnormality of the prostate (HP:0008775)	1.88521753
81	Chronic hepatic failure (HP:0100626)	1.87709846
82	Clubbing of toes (HP:0100760)	1.86885390
83	Acute encephalopathy (HP:0006846)	1.86184964
84	Postaxial foot polydactyly (HP:0001830)	1.85843474
85	Renal cortical cysts (HP:0000803)	1.85304812
86	Abnormal drinking behavior (HP:0030082)	1.85048076
87	Polydipsia (HP:0001959)	1.85048076
88	Duplicated collecting system (HP:0000081)	1.84739896
89	Gaze-evoked nystagmus (HP:0000640)	1.84724212
90	Dyschromatopsia (HP:0007641)	1.84683365
91	Tubulointerstitial fibrosis (HP:0005576)	1.82961467
92	Metaphyseal dysplasia (HP:0100255)	1.82247511
93	Left ventricular hypertrophy (HP:0001712)	1.82093942
94	Photophobia (HP:0000613)	1.81700574
95	Hypoplastic ischia (HP:0003175)	1.79689203
96	Retinitis pigmentosa (HP:0000510)	1.79329760
97	Sclerocornea (HP:0000647)	1.78461032
98	Broad foot (HP:0001769)	1.77960621
99	Nephrotic syndrome (HP:0000100)	1.77264722
100	Type 2 muscle fiber atrophy (HP:0003554)	1.75225488

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.21530200
2	VRK2	3.81895767
3	PLK4	3.74858025
4	MAP4K2	3.21105455
5	NUAK1	2.56236611
6	TAF1	2.41809759
7	MST4	2.36715051
8	TAOK3	2.33330030
9	PLK2	2.23220355
10	STK16	2.22047371
11	MAP3K12	2.20854967
12	INSRR	2.05073236
13	BMPR1B	1.95543246
14	VRK1	1.88981386
15	ADRBK2	1.86254861
16	DDR2	1.82054558
17	ZAK	1.81385942
18	GRK1	1.75442912
19	TXK	1.74791480
20	TLK1	1.73159084
21	OXSR1	1.57983265
22	CDK19	1.57651075
23	PIK3CG	1.55294879
24	MYLK	1.48238344
25	MAPK15	1.37519609
26	CCNB1	1.24427534
27	IKBKB	1.24206449
28	DAPK1	1.22320253
29	CSNK1A1L	1.21432614
30	MAPKAPK5	1.18303119
31	CSNK1G3	1.11896111
32	DAPK2	1.11537970
33	CSNK1G2	1.02632979
34	FLT3	1.02593788
35	TGFBR1	1.02541672
36	BCR	1.01915201
37	GRK5	1.01623773
38	MKNK1	1.01605636
39	CSNK1G1	0.97607402
40	ADRBK1	0.96558584
41	MKNK2	0.95104353
42	PLK3	0.95077591
43	TIE1	0.94054059
44	TEC	0.89836951
45	PRKAA2	0.84609587
46	WNK3	0.84376158
47	GRK7	0.84204582
48	IRAK1	0.80780018
49	PRKCE	0.80606258
50	TRIM28	0.80055201
51	PRKCG	0.75655089
52	ITK	0.74238365
53	KDR	0.70028378
54	EPHA4	0.69215834
55	EIF2AK3	0.68385968
56	KIT	0.68326851
57	CDK8	0.64770039
58	EIF2AK1	0.63950421
59	NEK6	0.63354259
60	DYRK2	0.62906262
61	MAPKAPK3	0.61532973
62	STK38L	0.60978195
63	DAPK3	0.60336661
64	STK39	0.59624077
65	ERBB3	0.54504700
66	CHUK	0.53600013
67	PDK2	0.52194834
68	PAK3	0.51491861
69	PRKG1	0.51195100
70	CSNK1A1	0.49841401
71	BMPR2	0.49420307
72	IKBKE	0.48998601
73	SRPK1	0.48690150
74	BTK	0.47795034
75	PAK6	0.46407199
76	MAP4K1	0.46388723
77	BLK	0.43488535
78	EIF2AK2	0.41426091
79	TSSK6	0.40051122
80	WNK4	0.39963773
81	IGF1R	0.38949594
82	PINK1	0.38334179
83	MUSK	0.38112364
84	TESK1	0.38075527
85	SYK	0.37932374
86	CAMK2A	0.35701317
87	BRD4	0.35543060
88	FGFR2	0.35370467
89	FER	0.34346253
90	ACVR1B	0.33757266
91	LYN	0.32295078
92	PRKCA	0.31199741
93	MAPK13	0.30961610
94	JAK3	0.30637606
95	NME1	0.30556072
96	PTK2B	0.29617069
97	PDK1	0.29531567
98	PHKG1	0.29274203
99	PHKG2	0.29274203
100	BRSK2	0.29185311

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.42970403
2	Butanoate metabolism_Homo sapiens_hsa00650	2.56353269
3	Proteasome_Homo sapiens_hsa03050	2.43724610
4	Propanoate metabolism_Homo sapiens_hsa00640	2.37928563
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31548848
6	Homologous recombination_Homo sapiens_hsa03440	1.98866554
7	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95748526
8	Protein export_Homo sapiens_hsa03060	1.92355853
9	Antigen processing and presentation_Homo sapiens_hsa04612	1.84394164
10	One carbon pool by folate_Homo sapiens_hsa00670	1.82899381
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.82369267
12	Parkinsons disease_Homo sapiens_hsa05012	1.81207727
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80038121
14	Allograft rejection_Homo sapiens_hsa05330	1.78816944
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78636801
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.78575623
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76712107
18	Taste transduction_Homo sapiens_hsa04742	1.73912331
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.70074486
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.68576272
21	Olfactory transduction_Homo sapiens_hsa04740	1.67548988
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66162149
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65462106
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.63531236
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.59624286
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.58850437
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.55825260
28	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.55742766
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53499296
30	Phototransduction_Homo sapiens_hsa04744	1.51879180
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49892888
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45244981
33	Huntingtons disease_Homo sapiens_hsa05016	1.40154703
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36392299
35	Mismatch repair_Homo sapiens_hsa03430	1.27246220
36	Basal transcription factors_Homo sapiens_hsa03022	1.23915416
37	RNA degradation_Homo sapiens_hsa03018	1.23492647
38	Asthma_Homo sapiens_hsa05310	1.22635851
39	Peroxisome_Homo sapiens_hsa04146	1.17407384
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.10770786
41	Fatty acid degradation_Homo sapiens_hsa00071	1.10356513
42	Nicotine addiction_Homo sapiens_hsa05033	1.09430419
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07905973
44	Mineral absorption_Homo sapiens_hsa04978	1.06161287
45	Alzheimers disease_Homo sapiens_hsa05010	1.05712471
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05182439
47	RNA polymerase_Homo sapiens_hsa03020	0.98233138
48	Ribosome_Homo sapiens_hsa03010	0.97790738
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97584112
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.96126988
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.95305096
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.93081972
53	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.93006027
54	Caffeine metabolism_Homo sapiens_hsa00232	0.91197679
55	Fatty acid elongation_Homo sapiens_hsa00062	0.89310372
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88885480
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.88371474
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87995318
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.82178786
60	RNA transport_Homo sapiens_hsa03013	0.81948583
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.80565766
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78969558
63	Purine metabolism_Homo sapiens_hsa00230	0.78760981
64	ABC transporters_Homo sapiens_hsa02010	0.77560162
65	Retinol metabolism_Homo sapiens_hsa00830	0.77233274
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74579277
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74064706
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73077563
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.72765032
70	Histidine metabolism_Homo sapiens_hsa00340	0.68388797
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.67958615
72	Base excision repair_Homo sapiens_hsa03410	0.67888636
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67399794
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67006673
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65070180
76	Glutathione metabolism_Homo sapiens_hsa00480	0.64071623
77	Salivary secretion_Homo sapiens_hsa04970	0.62314345
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62150545
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.58741100
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55411235
81	Pancreatic secretion_Homo sapiens_hsa04972	0.53285013
82	Morphine addiction_Homo sapiens_hsa05032	0.52357483
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50218728
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50082583
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50054325
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49746740
87	Serotonergic synapse_Homo sapiens_hsa04726	0.49444758
88	Sulfur metabolism_Homo sapiens_hsa00920	0.48410690
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.47743890
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47248379
91	Metabolic pathways_Homo sapiens_hsa01100	0.46482599
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44954294
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43631279
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41344012
95	Spliceosome_Homo sapiens_hsa03040	0.41124967
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39514030
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39154521
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38428287
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37972606
100	Renin secretion_Homo sapiens_hsa04924	0.35141936

TOX4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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