ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.84187206
2	presynaptic membrane assembly (GO:0097105)	4.42282560
3	nucleobase catabolic process (GO:0046113)	4.13574266
4	limb bud formation (GO:0060174)	3.96111782
5	presynaptic membrane organization (GO:0097090)	3.95773532
6	axonal fasciculation (GO:0007413)	3.53163021
7	postsynaptic membrane organization (GO:0001941)	3.53120928
8	central nervous system projection neuron axonogenesis (GO:0021952)	3.47776000
9	establishment of nucleus localization (GO:0040023)	3.40538028
10	neuron cell-cell adhesion (GO:0007158)	3.30431524
11	neuron recognition (GO:0008038)	3.27151371
12	olfactory bulb development (GO:0021772)	3.16548749
13	cerebral cortex radially oriented cell migration (GO:0021799)	3.12029721
14	central nervous system neuron axonogenesis (GO:0021955)	3.10160812
15	vocalization behavior (GO:0071625)	3.08507292
16	intraciliary transport (GO:0042073)	3.08413871
17	sympathetic nervous system development (GO:0048485)	3.04138732
18	transmission of nerve impulse (GO:0019226)	3.03920364
19	spinal cord development (GO:0021510)	3.02393457
20	epithelial cilium movement (GO:0003351)	2.99227094
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96657252
22	neural tube formation (GO:0001841)	2.95393658
23	retinal ganglion cell axon guidance (GO:0031290)	2.94528128
24	dendritic spine morphogenesis (GO:0060997)	2.94048429
25	negative regulation of dendrite development (GO:2000171)	2.91950896
26	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.85962348
27	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.85962348
28	regulation of translation, ncRNA-mediated (GO:0045974)	2.85962348
29	cilium movement (GO:0003341)	2.81939485
30	glial cell proliferation (GO:0014009)	2.80375840
31	neurotransmitter-gated ion channel clustering (GO:0072578)	2.79804382
32	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.65042534
33	negative regulation of axon guidance (GO:1902668)	2.63214083
34	synapse assembly (GO:0007416)	2.62697175
35	kidney morphogenesis (GO:0060993)	2.60106615
36	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.59800245
37	protein localization to synapse (GO:0035418)	2.58519766
38	atrial cardiac muscle cell action potential (GO:0086014)	2.58237136
39	protein localization to cilium (GO:0061512)	2.55245576
40	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.55126836
41	cilium assembly (GO:0042384)	2.53510141
42	cornea development in camera-type eye (GO:0061303)	2.53263900
43	cilium or flagellum-dependent cell motility (GO:0001539)	2.53200986
44	cilium organization (GO:0044782)	2.52789585
45	regulation of axon guidance (GO:1902667)	2.51849711
46	dendrite morphogenesis (GO:0048813)	2.51087340
47	limb development (GO:0060173)	2.49781706
48	appendage development (GO:0048736)	2.49781706
49	regulation of telomere maintenance (GO:0032204)	2.48789936
50	cerebral cortex cell migration (GO:0021795)	2.48174606
51	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.45035929
52	axon extension involved in axon guidance (GO:0048846)	2.45035929
53	regulation of collateral sprouting (GO:0048670)	2.43392581
54	negative chemotaxis (GO:0050919)	2.42485188
55	protein polyglutamylation (GO:0018095)	2.42191377
56	somite development (GO:0061053)	2.41773021
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.41178833
58	cilium morphogenesis (GO:0060271)	2.38198396
59	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.37578496
60	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.37088494
61	hindbrain development (GO:0030902)	2.36510768
62	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.36417390
63	auditory behavior (GO:0031223)	2.34853492
64	regulation of axon extension involved in axon guidance (GO:0048841)	2.34659108
65	negative regulation of DNA recombination (GO:0045910)	2.33584123
66	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.33244674
67	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.33051882
68	glutamate receptor signaling pathway (GO:0007215)	2.32785627
69	histone H2A acetylation (GO:0043968)	2.32746306
70	mechanosensory behavior (GO:0007638)	2.32622039
71	establishment of mitochondrion localization (GO:0051654)	2.32162007
72	regulation of cilium movement (GO:0003352)	2.29791039
73	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.29308837
74	hippocampus development (GO:0021766)	2.29271250
75	nonmotile primary cilium assembly (GO:0035058)	2.28420210
76	nucleus localization (GO:0051647)	2.27669716
77	pre-miRNA processing (GO:0031054)	2.24818155
78	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.24365399
79	replication fork processing (GO:0031297)	2.23988451
80	startle response (GO:0001964)	2.23804464
81	acrosome assembly (GO:0001675)	2.21959976
82	ganglion development (GO:0061548)	2.21501853
83	synaptic vesicle maturation (GO:0016188)	2.21249653
84	microtubule bundle formation (GO:0001578)	2.21236437
85	axoneme assembly (GO:0035082)	2.20374058
86	neuronal action potential propagation (GO:0019227)	2.20257396
87	cellular component assembly involved in morphogenesis (GO:0010927)	2.20053262
88	axon extension (GO:0048675)	2.19622857
89	microtubule depolymerization (GO:0007019)	2.18228751
90	cerebral cortex development (GO:0021987)	2.17306715
91	brain morphogenesis (GO:0048854)	2.16961793
92	cytoplasmic mRNA processing body assembly (GO:0033962)	2.16500208
93	regulation of dendritic spine morphogenesis (GO:0061001)	2.16328330
94	forebrain neuron differentiation (GO:0021879)	2.15331035
95	DNA double-strand break processing (GO:0000729)	2.15306579
96	dendrite development (GO:0016358)	2.15027644
97	innervation (GO:0060384)	2.14720855
98	neuronal ion channel clustering (GO:0045161)	2.14555646
99	smoothened signaling pathway (GO:0007224)	2.14475573
100	ephrin receptor signaling pathway (GO:0048013)	2.12854134

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.52257542
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.51756230
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.15819230
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.01004214
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.94926488
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.70834409
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70453465
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62866319
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.57169438
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57078719
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52258547
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.47475930
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34785307
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21489137
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.14597715
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14240227
17	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.09614783
18	P300_19829295_ChIP-Seq_ESCs_Human	2.05385354
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.92672008
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.92599166
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.92170841
22	EWS_26573619_Chip-Seq_HEK293_Human	1.91487658
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90022938
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86985462
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.81484069
26	VDR_22108803_ChIP-Seq_LS180_Human	1.79581359
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75316172
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71303037
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70497533
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.69822866
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67834831
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63494854
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62443067
34	STAT3_23295773_ChIP-Seq_U87_Human	1.62038095
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56686964
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52581690
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51345675
38	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.45618068
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45343987
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44799503
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.44799503
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43522839
43	TCF4_23295773_ChIP-Seq_U87_Human	1.43405156
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.43315344
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39764701
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39764701
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.39519794
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37223258
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36759043
50	AR_25329375_ChIP-Seq_VCAP_Human	1.36540544
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34871727
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33099270
53	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.30696222
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.29139310
55	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27439353
56	SOX9_26525672_Chip-Seq_HEART_Mouse	1.27246129
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27203441
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.26879033
59	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.26862772
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26543815
61	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.24847211
62	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.24706853
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23705368
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22962604
65	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22636402
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19071762
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.17183283
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16931947
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15943239
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15852922
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15622046
72	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.14055784
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12325548
74	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11932767
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11777140
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11430828
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10867559
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.09645574
79	JUN_21703547_ChIP-Seq_K562_Human	1.09634185
80	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08907096
81	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.06509944
82	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06487108
83	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.06323930
84	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06082160
85	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05966600
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05612885
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05279992
88	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04708065
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04674947
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03834312
91	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.03738818
92	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.03566156
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02531635
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02283028
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01963054
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00938079
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99716873
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99304710
99	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.97445756
100	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.96691880

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.73797041
2	MP0000778_abnormal_nervous_system	2.58339060
3	MP0004270_analgesia	2.48262702
4	MP0003122_maternal_imprinting	2.45932539
5	MP0001984_abnormal_olfaction	2.30053073
6	MP0004859_abnormal_synaptic_plasticity	2.24358945
7	MP0003787_abnormal_imprinting	2.07170799
8	MP0008877_abnormal_DNA_methylation	1.98748704
9	MP0001529_abnormal_vocalization	1.98664803
10	MP0002102_abnormal_ear_morphology	1.89167964
11	MP0003121_genomic_imprinting	1.87128294
12	MP0002751_abnormal_autonomic_nervous	1.85974187
13	MP0006276_abnormal_autonomic_nervous	1.75109056
14	MP0002184_abnormal_innervation	1.68447809
15	MP0009046_muscle_twitch	1.65851924
16	MP0001486_abnormal_startle_reflex	1.62577141
17	MP0003635_abnormal_synaptic_transmissio	1.62278536
18	MP0002734_abnormal_mechanical_nocicepti	1.60897957
19	MP0003890_abnormal_embryonic-extraembry	1.60622214
20	MP0006072_abnormal_retinal_apoptosis	1.54127786
21	MP0005499_abnormal_olfactory_system	1.51756677
22	MP0005394_taste/olfaction_phenotype	1.51756677
23	MP0005187_abnormal_penis_morphology	1.50579875
24	MP0002938_white_spotting	1.50224285
25	MP0000631_abnormal_neuroendocrine_gland	1.48804335
26	MP0009745_abnormal_behavioral_response	1.46807138
27	MP0001299_abnormal_eye_distance/	1.44302855
28	MP0002063_abnormal_learning/memory/cond	1.42282700
29	MP0006292_abnormal_olfactory_placode	1.41949041
30	MP0000955_abnormal_spinal_cord	1.41824236
31	MP0008789_abnormal_olfactory_epithelium	1.40754887
32	MP0002233_abnormal_nose_morphology	1.39706693
33	MP0005253_abnormal_eye_physiology	1.39559703
34	MP0003937_abnormal_limbs/digits/tail_de	1.36749454
35	MP0001968_abnormal_touch/_nociception	1.36121628
36	MP0002234_abnormal_pharynx_morphology	1.35277164
37	MP0002272_abnormal_nervous_system	1.33771598
38	MP0002822_catalepsy	1.33236779
39	MP0002572_abnormal_emotion/affect_behav	1.32493739
40	MP0009780_abnormal_chondrocyte_physiolo	1.31982101
41	MP0002736_abnormal_nociception_after	1.31309220
42	MP0003861_abnormal_nervous_system	1.31142647
43	MP0002557_abnormal_social/conspecific_i	1.30226299
44	MP0004811_abnormal_neuron_physiology	1.28943334
45	MP0000569_abnormal_digit_pigmentation	1.28787065
46	MP0004133_heterotaxia	1.26432164
47	MP0005367_renal/urinary_system_phenotyp	1.23644368
48	MP0000516_abnormal_urinary_system	1.23644368
49	MP0003755_abnormal_palate_morphology	1.21744980
50	MP0001177_atelectasis	1.21020363
51	MP0002882_abnormal_neuron_morphology	1.20534340
52	MP0003119_abnormal_digestive_system	1.20119738
53	MP0002735_abnormal_chemical_nociception	1.19733524
54	MP0004924_abnormal_behavior	1.19138724
55	MP0005386_behavior/neurological_phenoty	1.19138724
56	MP0001293_anophthalmia	1.17206917
57	MP0002064_seizures	1.16408409
58	MP0008057_abnormal_DNA_replication	1.15323485
59	MP0005645_abnormal_hypothalamus_physiol	1.15263848
60	MP0000647_abnormal_sebaceous_gland	1.15180989
61	MP0002152_abnormal_brain_morphology	1.15064984
62	MP0005551_abnormal_eye_electrophysiolog	1.14015130
63	MP0002638_abnormal_pupillary_reflex	1.13784676
64	MP0000534_abnormal_ureter_morphology	1.11494791
65	MP0005423_abnormal_somatic_nervous	1.10460510
66	MP0004885_abnormal_endolymph	1.08191922
67	MP0003385_abnormal_body_wall	1.05935768
68	MP0005248_abnormal_Harderian_gland	1.05403020
69	MP0000566_synostosis	1.05080670
70	MP0002653_abnormal_ependyma_morphology	1.04682507
71	MP0003283_abnormal_digestive_organ	1.04135871
72	MP0002909_abnormal_adrenal_gland	1.02230969
73	MP0003942_abnormal_urinary_system	1.01431720
74	MP0002067_abnormal_sensory_capabilities	1.01317922
75	MP0002752_abnormal_somatic_nervous	1.01077997
76	MP0003935_abnormal_craniofacial_develop	1.00736639
77	MP0000383_abnormal_hair_follicle	0.98555772
78	MP0008995_early_reproductive_senescence	0.98383579
79	MP0000049_abnormal_middle_ear	0.97799859
80	MP0003938_abnormal_ear_development	0.95330067
81	MP0005391_vision/eye_phenotype	0.94301060
82	MP0009703_decreased_birth_body	0.93700182
83	MP0000537_abnormal_urethra_morphology	0.92239557
84	MP0000427_abnormal_hair_cycle	0.92219379
85	MP0001188_hyperpigmentation	0.90097923
86	MP0008058_abnormal_DNA_repair	0.86295923
87	MP0001970_abnormal_pain_threshold	0.85912657
88	MP0001286_abnormal_eye_development	0.85290686
89	MP0002081_perinatal_lethality	0.84923331
90	MP0002697_abnormal_eye_size	0.84556729
91	MP0010030_abnormal_orbit_morphology	0.82721369
92	MP0002084_abnormal_developmental_patter	0.82374300
93	MP0003698_abnormal_male_reproductive	0.80697769
94	MP0005646_abnormal_pituitary_gland	0.79670289
95	MP0001502_abnormal_circadian_rhythm	0.79556618
96	MP0002066_abnormal_motor_capabilities/c	0.77472216
97	MP0002282_abnormal_trachea_morphology	0.76641035
98	MP0003567_abnormal_fetal_cardiomyocyte	0.76108368
99	MP0002116_abnormal_craniofacial_bone	0.75808413
100	MP0005379_endocrine/exocrine_gland_phen	0.75241383

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.74281327
2	Tubulointerstitial nephritis (HP:0001970)	2.88532416
3	Drooling (HP:0002307)	2.81197151
4	Intestinal atresia (HP:0011100)	2.78230060
5	Volvulus (HP:0002580)	2.65771836
6	Hyperventilation (HP:0002883)	2.63136491
7	Pancreatic fibrosis (HP:0100732)	2.62474679
8	Focal seizures (HP:0007359)	2.56321139
9	Astrocytoma (HP:0009592)	2.50632795
10	Abnormality of the astrocytes (HP:0100707)	2.50632795
11	Nephronophthisis (HP:0000090)	2.49195811
12	Excessive salivation (HP:0003781)	2.47856303
13	Focal motor seizures (HP:0011153)	2.43717972
14	Ependymoma (HP:0002888)	2.42543091
15	Aqueductal stenosis (HP:0002410)	2.40048902
16	Pancreatic cysts (HP:0001737)	2.39293712
17	Renal hypoplasia (HP:0000089)	2.38354444
18	True hermaphroditism (HP:0010459)	2.32982245
19	Febrile seizures (HP:0002373)	2.32125016
20	Genital tract atresia (HP:0001827)	2.31485795
21	Broad-based gait (HP:0002136)	2.31070262
22	Chronic hepatic failure (HP:0100626)	2.24414956
23	Cutaneous finger syndactyly (HP:0010554)	2.23274692
24	Gait imbalance (HP:0002141)	2.21710432
25	Vaginal atresia (HP:0000148)	2.21490722
26	Abnormality of the renal medulla (HP:0100957)	2.17060661
27	Progressive cerebellar ataxia (HP:0002073)	2.15915167
28	Hepatoblastoma (HP:0002884)	2.15179548
29	Medial flaring of the eyebrow (HP:0010747)	2.13722491
30	Abnormality of the lower motor neuron (HP:0002366)	2.12491258
31	Glioma (HP:0009733)	2.12323999
32	Absent/shortened dynein arms (HP:0200106)	2.11610107
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11610107
34	Lissencephaly (HP:0001339)	2.10795549
35	Gaze-evoked nystagmus (HP:0000640)	2.10495748
36	Neoplasm of the oral cavity (HP:0100649)	2.10109672
37	Molar tooth sign on MRI (HP:0002419)	2.09477128
38	Abnormality of midbrain morphology (HP:0002418)	2.09477128
39	Occipital encephalocele (HP:0002085)	2.07129928
40	Nephrogenic diabetes insipidus (HP:0009806)	2.05261850
41	Narrow forehead (HP:0000341)	2.03455155
42	Absent speech (HP:0001344)	2.03130868
43	Atonic seizures (HP:0010819)	2.02080327
44	Congenital primary aphakia (HP:0007707)	2.00271657
45	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98968447
46	Abnormal respiratory epithelium morphology (HP:0012253)	1.98968447
47	Abnormality of the ischium (HP:0003174)	1.93951713
48	Cystic liver disease (HP:0006706)	1.93629549
49	Abnormality of the antihelix (HP:0009738)	1.93568210
50	Abnormal ciliary motility (HP:0012262)	1.93556594
51	Papillary thyroid carcinoma (HP:0002895)	1.91346024
52	Postaxial hand polydactyly (HP:0001162)	1.90796221
53	Abnormality of the corticospinal tract (HP:0002492)	1.89739188
54	Exotropia (HP:0000577)	1.87279269
55	Hypsarrhythmia (HP:0002521)	1.86981458
56	EEG with generalized epileptiform discharges (HP:0011198)	1.86522583
57	Heterotopia (HP:0002282)	1.86259516
58	Hypoplastic ischia (HP:0003175)	1.85481371
59	Cutaneous syndactyly (HP:0012725)	1.84957053
60	Epileptiform EEG discharges (HP:0011182)	1.84857703
61	Hip dysplasia (HP:0001385)	1.83818834
62	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.82362133
63	Gastrointestinal atresia (HP:0002589)	1.82063822
64	Postaxial foot polydactyly (HP:0001830)	1.80945820
65	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.80611360
66	Colon cancer (HP:0003003)	1.78445614
67	Pachygyria (HP:0001302)	1.78190671
68	Short 4th metacarpal (HP:0010044)	1.76975154
69	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.76975154
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76059836
71	Amyotrophic lateral sclerosis (HP:0007354)	1.76041272
72	Cortical dysplasia (HP:0002539)	1.74557579
73	Bifid tongue (HP:0010297)	1.73453044
74	Scrotal hypoplasia (HP:0000046)	1.72887186
75	Labial hypoplasia (HP:0000066)	1.72699724
76	Rhinitis (HP:0012384)	1.71900578
77	Micropenis (HP:0000054)	1.71489079
78	Vitreoretinal degeneration (HP:0000655)	1.71210721
79	Cupped ear (HP:0000378)	1.70190088
80	Oligodactyly (hands) (HP:0001180)	1.69364037
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68414780
82	Poor coordination (HP:0002370)	1.68333986
83	Optic nerve hypoplasia (HP:0000609)	1.67915502
84	Rhabdomyosarcoma (HP:0002859)	1.66898148
85	Genetic anticipation (HP:0003743)	1.66023046
86	Polyphagia (HP:0002591)	1.64436253
87	Medulloblastoma (HP:0002885)	1.63653282
88	Abnormality of the metopic suture (HP:0005556)	1.63623282
89	Preaxial hand polydactyly (HP:0001177)	1.63427680
90	Anophthalmia (HP:0000528)	1.62666617
91	Tented upper lip vermilion (HP:0010804)	1.62485000
92	Specific learning disability (HP:0001328)	1.60743098
93	Abnormality of the parathyroid morphology (HP:0011766)	1.60358932
94	Thyroid carcinoma (HP:0002890)	1.60041641
95	Epileptic encephalopathy (HP:0200134)	1.59945958
96	Neoplasm of the adrenal cortex (HP:0100641)	1.59731070
97	Hemiparesis (HP:0001269)	1.58906420
98	Gastroesophageal reflux (HP:0002020)	1.57876131
99	Obsessive-compulsive behavior (HP:0000722)	1.56846449
100	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.55699510

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.92353975
2	CASK	3.56357069
3	WNK3	2.95908375
4	EPHA4	2.81078007
5	FRK	2.80514990
6	MAP3K4	2.80312189
7	BCR	2.63382636
8	TRIM28	2.57561619
9	PNCK	2.38467671
10	TNIK	2.28538426
11	MKNK2	2.02604179
12	FGFR2	2.02350299
13	MAP4K2	1.77626555
14	PAK3	1.66372168
15	PLK2	1.64514311
16	NTRK3	1.50486020
17	BRD4	1.49649273
18	MAP2K7	1.48423264
19	ERBB3	1.48245037
20	MAPK13	1.47583482
21	DYRK2	1.43236246
22	MKNK1	1.42172703
23	STK38L	1.32808080
24	PINK1	1.31167568
25	CSNK1G2	1.28554072
26	NTRK2	1.27543007
27	CAMK1G	1.27079236
28	TSSK6	1.26877828
29	SRPK1	1.23811569
30	PLK4	1.21679527
31	AKT3	1.19540798
32	LATS1	1.17944934
33	CSNK1G1	1.17142591
34	BMPR1B	1.16599629
35	EPHB2	1.12302550
36	PLK3	1.08187335
37	CSNK1A1L	1.05824209
38	SGK2	1.05603636
39	CSNK1G3	1.03307551
40	MINK1	1.01574523
41	KSR1	0.95591598
42	NUAK1	0.91260521
43	EPHA3	0.90715323
44	INSRR	0.89556971
45	PHKG2	0.89453564
46	PHKG1	0.89453564
47	FER	0.89181934
48	STK39	0.88733673
49	SGK223	0.87697012
50	SGK494	0.87697012
51	PRKCE	0.86033018
52	NTRK1	0.85561189
53	BRSK2	0.84711745
54	PRKCG	0.80357565
55	PAK6	0.80038969
56	UHMK1	0.79977099
57	DYRK1A	0.74827860
58	EIF2AK3	0.73403607
59	DYRK3	0.73184199
60	MAP2K4	0.69048769
61	CDK3	0.68083210
62	FGFR1	0.66241339
63	WEE1	0.65735233
64	GRK1	0.65206254
65	CDK5	0.63399732
66	OXSR1	0.60546317
67	DAPK2	0.58821104
68	* ATM	0.58636601
69	ZAK	0.57501941
70	YES1	0.56502718
71	TTK	0.56221788
72	PRKD3	0.56091029
73	CAMK2A	0.53767163
74	SGK3	0.53596007
75	PKN1	0.51769614
76	CSNK1D	0.51409870
77	CSNK1E	0.50532351
78	CDC7	0.50407818
79	ACVR1B	0.49896798
80	ERBB2	0.48542983
81	STK3	0.46559286
82	ADRBK2	0.46519583
83	CAMK1D	0.46223001
84	* PRKDC	0.45981859
85	PRKAA1	0.45658304
86	* PLK1	0.43146043
87	FLT3	0.39417210
88	BUB1	0.38386697
89	PRKCZ	0.38194082
90	WNK1	0.37906730
91	* GSK3B	0.37540878
92	* CDK1	0.37461051
93	ATR	0.37232661
94	WNK4	0.37201464
95	STK11	0.36186704
96	CSNK1A1	0.35600904
97	RPS6KA4	0.35147472
98	ROCK1	0.34940912
99	CAMK1	0.34879749
100	CAMK4	0.33264837

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.99818348
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49396408
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.31048297
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95060748
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.85014326
6	Protein export_Homo sapiens_hsa03060	1.83475824
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.78639397
8	GABAergic synapse_Homo sapiens_hsa04727	1.78452777
9	Axon guidance_Homo sapiens_hsa04360	1.75899080
10	Glutamatergic synapse_Homo sapiens_hsa04724	1.73160351
11	Insulin secretion_Homo sapiens_hsa04911	1.73081941
12	Circadian entrainment_Homo sapiens_hsa04713	1.70959671
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.69032187
14	Taste transduction_Homo sapiens_hsa04742	1.66662730
15	Butanoate metabolism_Homo sapiens_hsa00650	1.61234438
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.61183485
17	Propanoate metabolism_Homo sapiens_hsa00640	1.60539547
18	Phototransduction_Homo sapiens_hsa04744	1.56542495
19	Basal cell carcinoma_Homo sapiens_hsa05217	1.52611217
20	Cocaine addiction_Homo sapiens_hsa05030	1.50243771
21	Morphine addiction_Homo sapiens_hsa05032	1.46987020
22	Amphetamine addiction_Homo sapiens_hsa05031	1.44312392
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.42845420
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39378423
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37299794
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.29781153
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.29185360
28	Basal transcription factors_Homo sapiens_hsa03022	1.29182638
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.28015351
30	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.23604118
31	Wnt signaling pathway_Homo sapiens_hsa04310	1.22287628
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20481236
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16213891
34	Oocyte meiosis_Homo sapiens_hsa04114	1.14754744
35	Lysine degradation_Homo sapiens_hsa00310	1.14198229
36	Circadian rhythm_Homo sapiens_hsa04710	1.12836827
37	Long-term depression_Homo sapiens_hsa04730	1.10913579
38	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.05157419
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04553438
40	Serotonergic synapse_Homo sapiens_hsa04726	1.04142895
41	Cholinergic synapse_Homo sapiens_hsa04725	1.03724232
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01914293
43	RNA transport_Homo sapiens_hsa03013	1.01359810
44	Tight junction_Homo sapiens_hsa04530	1.00008694
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98663109
46	Olfactory transduction_Homo sapiens_hsa04740	0.96733976
47	Melanogenesis_Homo sapiens_hsa04916	0.95370569
48	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.95163083
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.94722087
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92878966
51	RNA degradation_Homo sapiens_hsa03018	0.91260171
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.91115954
53	Adherens junction_Homo sapiens_hsa04520	0.90968945
54	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.87138642
55	Regulation of autophagy_Homo sapiens_hsa04140	0.85783396
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.84981125
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84971796
58	Salivary secretion_Homo sapiens_hsa04970	0.83633980
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.83379020
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.83221684
61	Colorectal cancer_Homo sapiens_hsa05210	0.82788138
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81761553
63	Gap junction_Homo sapiens_hsa04540	0.81207220
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80791927
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.78345636
66	Renin secretion_Homo sapiens_hsa04924	0.76558258
67	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.75078653
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73846015
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.73787865
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.71825789
71	Cell cycle_Homo sapiens_hsa04110	0.71711601
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71617987
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.67757065
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67281776
75	Gastric acid secretion_Homo sapiens_hsa04971	0.65757742
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.64581003
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.64332529
78	Homologous recombination_Homo sapiens_hsa03440	0.63672980
79	Alcoholism_Homo sapiens_hsa05034	0.62406807
80	Long-term potentiation_Homo sapiens_hsa04720	0.57590710
81	Mismatch repair_Homo sapiens_hsa03430	0.57499195
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57221678
83	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.56743415
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56586226
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55866538
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.51719608
87	MicroRNAs in cancer_Homo sapiens_hsa05206	0.51712378
88	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48153071
89	Estrogen signaling pathway_Homo sapiens_hsa04915	0.47761530
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47366571
91	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.45871293
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43283355
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42843029
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41970017
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.41647681
96	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.40831977
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40041471
98	ErbB signaling pathway_Homo sapiens_hsa04012	0.39699931
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37835962
100	ABC transporters_Homo sapiens_hsa02010	0.37759573

TP53BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »