TP53BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.84187206
2presynaptic membrane assembly (GO:0097105)4.42282560
3nucleobase catabolic process (GO:0046113)4.13574266
4limb bud formation (GO:0060174)3.96111782
5presynaptic membrane organization (GO:0097090)3.95773532
6axonal fasciculation (GO:0007413)3.53163021
7postsynaptic membrane organization (GO:0001941)3.53120928
8central nervous system projection neuron axonogenesis (GO:0021952)3.47776000
9establishment of nucleus localization (GO:0040023)3.40538028
10neuron cell-cell adhesion (GO:0007158)3.30431524
11neuron recognition (GO:0008038)3.27151371
12olfactory bulb development (GO:0021772)3.16548749
13cerebral cortex radially oriented cell migration (GO:0021799)3.12029721
14central nervous system neuron axonogenesis (GO:0021955)3.10160812
15vocalization behavior (GO:0071625)3.08507292
16intraciliary transport (GO:0042073)3.08413871
17sympathetic nervous system development (GO:0048485)3.04138732
18transmission of nerve impulse (GO:0019226)3.03920364
19spinal cord development (GO:0021510)3.02393457
20epithelial cilium movement (GO:0003351)2.99227094
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96657252
22neural tube formation (GO:0001841)2.95393658
23retinal ganglion cell axon guidance (GO:0031290)2.94528128
24dendritic spine morphogenesis (GO:0060997)2.94048429
25negative regulation of dendrite development (GO:2000171)2.91950896
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85962348
27negative regulation of translation, ncRNA-mediated (GO:0040033)2.85962348
28regulation of translation, ncRNA-mediated (GO:0045974)2.85962348
29cilium movement (GO:0003341)2.81939485
30glial cell proliferation (GO:0014009)2.80375840
31neurotransmitter-gated ion channel clustering (GO:0072578)2.79804382
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65042534
33negative regulation of axon guidance (GO:1902668)2.63214083
34synapse assembly (GO:0007416)2.62697175
35kidney morphogenesis (GO:0060993)2.60106615
36regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59800245
37protein localization to synapse (GO:0035418)2.58519766
38atrial cardiac muscle cell action potential (GO:0086014)2.58237136
39protein localization to cilium (GO:0061512)2.55245576
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55126836
41cilium assembly (GO:0042384)2.53510141
42cornea development in camera-type eye (GO:0061303)2.53263900
43cilium or flagellum-dependent cell motility (GO:0001539)2.53200986
44cilium organization (GO:0044782)2.52789585
45regulation of axon guidance (GO:1902667)2.51849711
46dendrite morphogenesis (GO:0048813)2.51087340
47limb development (GO:0060173)2.49781706
48appendage development (GO:0048736)2.49781706
49regulation of telomere maintenance (GO:0032204)2.48789936
50cerebral cortex cell migration (GO:0021795)2.48174606
51neuron projection extension involved in neuron projection guidance (GO:1902284)2.45035929
52axon extension involved in axon guidance (GO:0048846)2.45035929
53regulation of collateral sprouting (GO:0048670)2.43392581
54negative chemotaxis (GO:0050919)2.42485188
55protein polyglutamylation (GO:0018095)2.42191377
56somite development (GO:0061053)2.41773021
57negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41178833
58cilium morphogenesis (GO:0060271)2.38198396
59regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37578496
60negative regulation of axon extension involved in axon guidance (GO:0048843)2.37088494
61hindbrain development (GO:0030902)2.36510768
62positive regulation of dendritic spine morphogenesis (GO:0061003)2.36417390
63auditory behavior (GO:0031223)2.34853492
64regulation of axon extension involved in axon guidance (GO:0048841)2.34659108
65negative regulation of DNA recombination (GO:0045910)2.33584123
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.33244674
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.33051882
68glutamate receptor signaling pathway (GO:0007215)2.32785627
69histone H2A acetylation (GO:0043968)2.32746306
70mechanosensory behavior (GO:0007638)2.32622039
71establishment of mitochondrion localization (GO:0051654)2.32162007
72regulation of cilium movement (GO:0003352)2.29791039
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29308837
74hippocampus development (GO:0021766)2.29271250
75nonmotile primary cilium assembly (GO:0035058)2.28420210
76nucleus localization (GO:0051647)2.27669716
77pre-miRNA processing (GO:0031054)2.24818155
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24365399
79replication fork processing (GO:0031297)2.23988451
80startle response (GO:0001964)2.23804464
81acrosome assembly (GO:0001675)2.21959976
82ganglion development (GO:0061548)2.21501853
83synaptic vesicle maturation (GO:0016188)2.21249653
84microtubule bundle formation (GO:0001578)2.21236437
85axoneme assembly (GO:0035082)2.20374058
86neuronal action potential propagation (GO:0019227)2.20257396
87cellular component assembly involved in morphogenesis (GO:0010927)2.20053262
88axon extension (GO:0048675)2.19622857
89microtubule depolymerization (GO:0007019)2.18228751
90cerebral cortex development (GO:0021987)2.17306715
91brain morphogenesis (GO:0048854)2.16961793
92cytoplasmic mRNA processing body assembly (GO:0033962)2.16500208
93regulation of dendritic spine morphogenesis (GO:0061001)2.16328330
94forebrain neuron differentiation (GO:0021879)2.15331035
95DNA double-strand break processing (GO:0000729)2.15306579
96dendrite development (GO:0016358)2.15027644
97innervation (GO:0060384)2.14720855
98neuronal ion channel clustering (GO:0045161)2.14555646
99smoothened signaling pathway (GO:0007224)2.14475573
100ephrin receptor signaling pathway (GO:0048013)2.12854134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.52257542
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.51756230
3EZH2_22144423_ChIP-Seq_EOC_Human3.15819230
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01004214
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94926488
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70834409
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70453465
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62866319
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57169438
10IGF1R_20145208_ChIP-Seq_DFB_Human2.57078719
11ZNF274_21170338_ChIP-Seq_K562_Hela2.52258547
12TAF15_26573619_Chip-Seq_HEK293_Human2.47475930
13FUS_26573619_Chip-Seq_HEK293_Human2.34785307
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21489137
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14597715
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14240227
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09614783
18P300_19829295_ChIP-Seq_ESCs_Human2.05385354
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92672008
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92599166
21SMAD4_21799915_ChIP-Seq_A2780_Human1.92170841
22EWS_26573619_Chip-Seq_HEK293_Human1.91487658
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90022938
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86985462
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81484069
26VDR_22108803_ChIP-Seq_LS180_Human1.79581359
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.75316172
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.71303037
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70497533
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.69822866
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67834831
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63494854
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62443067
34STAT3_23295773_ChIP-Seq_U87_Human1.62038095
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56686964
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.52581690
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51345675
38TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45618068
39REST_21632747_ChIP-Seq_MESCs_Mouse1.45343987
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44799503
41CBP_20019798_ChIP-Seq_JUKART_Human1.44799503
42RNF2_27304074_Chip-Seq_NSC_Mouse1.43522839
43TCF4_23295773_ChIP-Seq_U87_Human1.43405156
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43315344
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39764701
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39764701
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.39519794
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37223258
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36759043
50AR_25329375_ChIP-Seq_VCAP_Human1.36540544
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34871727
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.33099270
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30696222
54ER_23166858_ChIP-Seq_MCF-7_Human1.29139310
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27439353
56SOX9_26525672_Chip-Seq_HEART_Mouse1.27246129
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27203441
58AR_21572438_ChIP-Seq_LNCaP_Human1.26879033
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.26862772
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26543815
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24847211
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.24706853
63RUNX2_22187159_ChIP-Seq_PCA_Human1.23705368
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22962604
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22636402
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19071762
67BCAT_22108803_ChIP-Seq_LS180_Human1.17183283
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16931947
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15943239
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15852922
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15622046
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14055784
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12325548
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11932767
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11777140
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11430828
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10867559
78TCF4_22108803_ChIP-Seq_LS180_Human1.09645574
79JUN_21703547_ChIP-Seq_K562_Human1.09634185
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08907096
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06509944
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.06487108
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06323930
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06082160
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05966600
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.05612885
87P53_22387025_ChIP-Seq_ESCs_Mouse1.05279992
88TP53_18474530_ChIP-ChIP_U2OS_Human1.04708065
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04674947
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.03834312
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03738818
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.03566156
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.02531635
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02283028
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01963054
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.00938079
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.99716873
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99304710
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97445756
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.96691880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.73797041
2MP0000778_abnormal_nervous_system2.58339060
3MP0004270_analgesia2.48262702
4MP0003122_maternal_imprinting2.45932539
5MP0001984_abnormal_olfaction2.30053073
6MP0004859_abnormal_synaptic_plasticity2.24358945
7MP0003787_abnormal_imprinting2.07170799
8MP0008877_abnormal_DNA_methylation1.98748704
9MP0001529_abnormal_vocalization1.98664803
10MP0002102_abnormal_ear_morphology1.89167964
11MP0003121_genomic_imprinting1.87128294
12MP0002751_abnormal_autonomic_nervous1.85974187
13MP0006276_abnormal_autonomic_nervous1.75109056
14MP0002184_abnormal_innervation1.68447809
15MP0009046_muscle_twitch1.65851924
16MP0001486_abnormal_startle_reflex1.62577141
17MP0003635_abnormal_synaptic_transmissio1.62278536
18MP0002734_abnormal_mechanical_nocicepti1.60897957
19MP0003890_abnormal_embryonic-extraembry1.60622214
20MP0006072_abnormal_retinal_apoptosis1.54127786
21MP0005499_abnormal_olfactory_system1.51756677
22MP0005394_taste/olfaction_phenotype1.51756677
23MP0005187_abnormal_penis_morphology1.50579875
24MP0002938_white_spotting1.50224285
25MP0000631_abnormal_neuroendocrine_gland1.48804335
26MP0009745_abnormal_behavioral_response1.46807138
27MP0001299_abnormal_eye_distance/1.44302855
28MP0002063_abnormal_learning/memory/cond1.42282700
29MP0006292_abnormal_olfactory_placode1.41949041
30MP0000955_abnormal_spinal_cord1.41824236
31MP0008789_abnormal_olfactory_epithelium1.40754887
32MP0002233_abnormal_nose_morphology1.39706693
33MP0005253_abnormal_eye_physiology1.39559703
34MP0003937_abnormal_limbs/digits/tail_de1.36749454
35MP0001968_abnormal_touch/_nociception1.36121628
36MP0002234_abnormal_pharynx_morphology1.35277164
37MP0002272_abnormal_nervous_system1.33771598
38MP0002822_catalepsy1.33236779
39MP0002572_abnormal_emotion/affect_behav1.32493739
40MP0009780_abnormal_chondrocyte_physiolo1.31982101
41MP0002736_abnormal_nociception_after1.31309220
42MP0003861_abnormal_nervous_system1.31142647
43MP0002557_abnormal_social/conspecific_i1.30226299
44MP0004811_abnormal_neuron_physiology1.28943334
45MP0000569_abnormal_digit_pigmentation1.28787065
46MP0004133_heterotaxia1.26432164
47MP0005367_renal/urinary_system_phenotyp1.23644368
48MP0000516_abnormal_urinary_system1.23644368
49MP0003755_abnormal_palate_morphology1.21744980
50MP0001177_atelectasis1.21020363
51MP0002882_abnormal_neuron_morphology1.20534340
52MP0003119_abnormal_digestive_system1.20119738
53MP0002735_abnormal_chemical_nociception1.19733524
54MP0004924_abnormal_behavior1.19138724
55MP0005386_behavior/neurological_phenoty1.19138724
56MP0001293_anophthalmia1.17206917
57MP0002064_seizures1.16408409
58MP0008057_abnormal_DNA_replication1.15323485
59MP0005645_abnormal_hypothalamus_physiol1.15263848
60MP0000647_abnormal_sebaceous_gland1.15180989
61MP0002152_abnormal_brain_morphology1.15064984
62MP0005551_abnormal_eye_electrophysiolog1.14015130
63MP0002638_abnormal_pupillary_reflex1.13784676
64MP0000534_abnormal_ureter_morphology1.11494791
65MP0005423_abnormal_somatic_nervous1.10460510
66MP0004885_abnormal_endolymph1.08191922
67MP0003385_abnormal_body_wall1.05935768
68MP0005248_abnormal_Harderian_gland1.05403020
69MP0000566_synostosis1.05080670
70MP0002653_abnormal_ependyma_morphology1.04682507
71MP0003283_abnormal_digestive_organ1.04135871
72MP0002909_abnormal_adrenal_gland1.02230969
73MP0003942_abnormal_urinary_system1.01431720
74MP0002067_abnormal_sensory_capabilities1.01317922
75MP0002752_abnormal_somatic_nervous1.01077997
76MP0003935_abnormal_craniofacial_develop1.00736639
77MP0000383_abnormal_hair_follicle0.98555772
78MP0008995_early_reproductive_senescence0.98383579
79MP0000049_abnormal_middle_ear0.97799859
80MP0003938_abnormal_ear_development0.95330067
81MP0005391_vision/eye_phenotype0.94301060
82MP0009703_decreased_birth_body0.93700182
83MP0000537_abnormal_urethra_morphology0.92239557
84MP0000427_abnormal_hair_cycle0.92219379
85MP0001188_hyperpigmentation0.90097923
86MP0008058_abnormal_DNA_repair0.86295923
87MP0001970_abnormal_pain_threshold0.85912657
88MP0001286_abnormal_eye_development0.85290686
89MP0002081_perinatal_lethality0.84923331
90MP0002697_abnormal_eye_size0.84556729
91MP0010030_abnormal_orbit_morphology0.82721369
92MP0002084_abnormal_developmental_patter0.82374300
93MP0003698_abnormal_male_reproductive0.80697769
94MP0005646_abnormal_pituitary_gland0.79670289
95MP0001502_abnormal_circadian_rhythm0.79556618
96MP0002066_abnormal_motor_capabilities/c0.77472216
97MP0002282_abnormal_trachea_morphology0.76641035
98MP0003567_abnormal_fetal_cardiomyocyte0.76108368
99MP0002116_abnormal_craniofacial_bone0.75808413
100MP0005379_endocrine/exocrine_gland_phen0.75241383

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.74281327
2Tubulointerstitial nephritis (HP:0001970)2.88532416
3Drooling (HP:0002307)2.81197151
4Intestinal atresia (HP:0011100)2.78230060
5Volvulus (HP:0002580)2.65771836
6Hyperventilation (HP:0002883)2.63136491
7Pancreatic fibrosis (HP:0100732)2.62474679
8Focal seizures (HP:0007359)2.56321139
9Astrocytoma (HP:0009592)2.50632795
10Abnormality of the astrocytes (HP:0100707)2.50632795
11Nephronophthisis (HP:0000090)2.49195811
12Excessive salivation (HP:0003781)2.47856303
13Focal motor seizures (HP:0011153)2.43717972
14Ependymoma (HP:0002888)2.42543091
15Aqueductal stenosis (HP:0002410)2.40048902
16Pancreatic cysts (HP:0001737)2.39293712
17Renal hypoplasia (HP:0000089)2.38354444
18True hermaphroditism (HP:0010459)2.32982245
19Febrile seizures (HP:0002373)2.32125016
20Genital tract atresia (HP:0001827)2.31485795
21Broad-based gait (HP:0002136)2.31070262
22Chronic hepatic failure (HP:0100626)2.24414956
23Cutaneous finger syndactyly (HP:0010554)2.23274692
24Gait imbalance (HP:0002141)2.21710432
25Vaginal atresia (HP:0000148)2.21490722
26Abnormality of the renal medulla (HP:0100957)2.17060661
27Progressive cerebellar ataxia (HP:0002073)2.15915167
28Hepatoblastoma (HP:0002884)2.15179548
29Medial flaring of the eyebrow (HP:0010747)2.13722491
30Abnormality of the lower motor neuron (HP:0002366)2.12491258
31Glioma (HP:0009733)2.12323999
32Absent/shortened dynein arms (HP:0200106)2.11610107
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.11610107
34Lissencephaly (HP:0001339)2.10795549
35Gaze-evoked nystagmus (HP:0000640)2.10495748
36Neoplasm of the oral cavity (HP:0100649)2.10109672
37Molar tooth sign on MRI (HP:0002419)2.09477128
38Abnormality of midbrain morphology (HP:0002418)2.09477128
39Occipital encephalocele (HP:0002085)2.07129928
40Nephrogenic diabetes insipidus (HP:0009806)2.05261850
41Narrow forehead (HP:0000341)2.03455155
42Absent speech (HP:0001344)2.03130868
43Atonic seizures (HP:0010819)2.02080327
44Congenital primary aphakia (HP:0007707)2.00271657
45Abnormal respiratory motile cilium morphology (HP:0005938)1.98968447
46Abnormal respiratory epithelium morphology (HP:0012253)1.98968447
47Abnormality of the ischium (HP:0003174)1.93951713
48Cystic liver disease (HP:0006706)1.93629549
49Abnormality of the antihelix (HP:0009738)1.93568210
50Abnormal ciliary motility (HP:0012262)1.93556594
51Papillary thyroid carcinoma (HP:0002895)1.91346024
52Postaxial hand polydactyly (HP:0001162)1.90796221
53Abnormality of the corticospinal tract (HP:0002492)1.89739188
54Exotropia (HP:0000577)1.87279269
55Hypsarrhythmia (HP:0002521)1.86981458
56EEG with generalized epileptiform discharges (HP:0011198)1.86522583
57Heterotopia (HP:0002282)1.86259516
58Hypoplastic ischia (HP:0003175)1.85481371
59Cutaneous syndactyly (HP:0012725)1.84957053
60Epileptiform EEG discharges (HP:0011182)1.84857703
61Hip dysplasia (HP:0001385)1.83818834
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82362133
63Gastrointestinal atresia (HP:0002589)1.82063822
64Postaxial foot polydactyly (HP:0001830)1.80945820
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.80611360
66Colon cancer (HP:0003003)1.78445614
67Pachygyria (HP:0001302)1.78190671
68Short 4th metacarpal (HP:0010044)1.76975154
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76975154
70Abnormal respiratory motile cilium physiology (HP:0012261)1.76059836
71Amyotrophic lateral sclerosis (HP:0007354)1.76041272
72Cortical dysplasia (HP:0002539)1.74557579
73Bifid tongue (HP:0010297)1.73453044
74Scrotal hypoplasia (HP:0000046)1.72887186
75Labial hypoplasia (HP:0000066)1.72699724
76Rhinitis (HP:0012384)1.71900578
77Micropenis (HP:0000054)1.71489079
78Vitreoretinal degeneration (HP:0000655)1.71210721
79Cupped ear (HP:0000378)1.70190088
80Oligodactyly (hands) (HP:0001180)1.69364037
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.68414780
82Poor coordination (HP:0002370)1.68333986
83Optic nerve hypoplasia (HP:0000609)1.67915502
84Rhabdomyosarcoma (HP:0002859)1.66898148
85Genetic anticipation (HP:0003743)1.66023046
86Polyphagia (HP:0002591)1.64436253
87Medulloblastoma (HP:0002885)1.63653282
88Abnormality of the metopic suture (HP:0005556)1.63623282
89Preaxial hand polydactyly (HP:0001177)1.63427680
90Anophthalmia (HP:0000528)1.62666617
91Tented upper lip vermilion (HP:0010804)1.62485000
92Specific learning disability (HP:0001328)1.60743098
93Abnormality of the parathyroid morphology (HP:0011766)1.60358932
94Thyroid carcinoma (HP:0002890)1.60041641
95Epileptic encephalopathy (HP:0200134)1.59945958
96Neoplasm of the adrenal cortex (HP:0100641)1.59731070
97Hemiparesis (HP:0001269)1.58906420
98Gastroesophageal reflux (HP:0002020)1.57876131
99Obsessive-compulsive behavior (HP:0000722)1.56846449
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55699510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.92353975
2CASK3.56357069
3WNK32.95908375
4EPHA42.81078007
5FRK2.80514990
6MAP3K42.80312189
7BCR2.63382636
8TRIM282.57561619
9PNCK2.38467671
10TNIK2.28538426
11MKNK22.02604179
12FGFR22.02350299
13MAP4K21.77626555
14PAK31.66372168
15PLK21.64514311
16NTRK31.50486020
17BRD41.49649273
18MAP2K71.48423264
19ERBB31.48245037
20MAPK131.47583482
21DYRK21.43236246
22MKNK11.42172703
23STK38L1.32808080
24PINK11.31167568
25CSNK1G21.28554072
26NTRK21.27543007
27CAMK1G1.27079236
28TSSK61.26877828
29SRPK11.23811569
30PLK41.21679527
31AKT31.19540798
32LATS11.17944934
33CSNK1G11.17142591
34BMPR1B1.16599629
35EPHB21.12302550
36PLK31.08187335
37CSNK1A1L1.05824209
38SGK21.05603636
39CSNK1G31.03307551
40MINK11.01574523
41KSR10.95591598
42NUAK10.91260521
43EPHA30.90715323
44INSRR0.89556971
45PHKG20.89453564
46PHKG10.89453564
47FER0.89181934
48STK390.88733673
49SGK2230.87697012
50SGK4940.87697012
51PRKCE0.86033018
52NTRK10.85561189
53BRSK20.84711745
54PRKCG0.80357565
55PAK60.80038969
56UHMK10.79977099
57DYRK1A0.74827860
58EIF2AK30.73403607
59DYRK30.73184199
60MAP2K40.69048769
61CDK30.68083210
62FGFR10.66241339
63WEE10.65735233
64GRK10.65206254
65CDK50.63399732
66OXSR10.60546317
67DAPK20.58821104
68* ATM0.58636601
69ZAK0.57501941
70YES10.56502718
71TTK0.56221788
72PRKD30.56091029
73CAMK2A0.53767163
74SGK30.53596007
75PKN10.51769614
76CSNK1D0.51409870
77CSNK1E0.50532351
78CDC70.50407818
79ACVR1B0.49896798
80ERBB20.48542983
81STK30.46559286
82ADRBK20.46519583
83CAMK1D0.46223001
84* PRKDC0.45981859
85PRKAA10.45658304
86* PLK10.43146043
87FLT30.39417210
88BUB10.38386697
89PRKCZ0.38194082
90WNK10.37906730
91* GSK3B0.37540878
92* CDK10.37461051
93ATR0.37232661
94WNK40.37201464
95STK110.36186704
96CSNK1A10.35600904
97RPS6KA40.35147472
98ROCK10.34940912
99CAMK10.34879749
100CAMK40.33264837

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.99818348
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49396408
3Non-homologous end-joining_Homo sapiens_hsa034502.31048297
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95060748
5Hedgehog signaling pathway_Homo sapiens_hsa043401.85014326
6Protein export_Homo sapiens_hsa030601.83475824
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78639397
8GABAergic synapse_Homo sapiens_hsa047271.78452777
9Axon guidance_Homo sapiens_hsa043601.75899080
10Glutamatergic synapse_Homo sapiens_hsa047241.73160351
11Insulin secretion_Homo sapiens_hsa049111.73081941
12Circadian entrainment_Homo sapiens_hsa047131.70959671
13Steroid biosynthesis_Homo sapiens_hsa001001.69032187
14Taste transduction_Homo sapiens_hsa047421.66662730
15Butanoate metabolism_Homo sapiens_hsa006501.61234438
16Dopaminergic synapse_Homo sapiens_hsa047281.61183485
17Propanoate metabolism_Homo sapiens_hsa006401.60539547
18Phototransduction_Homo sapiens_hsa047441.56542495
19Basal cell carcinoma_Homo sapiens_hsa052171.52611217
20Cocaine addiction_Homo sapiens_hsa050301.50243771
21Morphine addiction_Homo sapiens_hsa050321.46987020
22Amphetamine addiction_Homo sapiens_hsa050311.44312392
23Hippo signaling pathway_Homo sapiens_hsa043901.42845420
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39378423
25Fanconi anemia pathway_Homo sapiens_hsa034601.37299794
26Selenocompound metabolism_Homo sapiens_hsa004501.29781153
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29185360
28Basal transcription factors_Homo sapiens_hsa030221.29182638
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28015351
30Synaptic vesicle cycle_Homo sapiens_hsa047211.23604118
31Wnt signaling pathway_Homo sapiens_hsa043101.22287628
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.20481236
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16213891
34Oocyte meiosis_Homo sapiens_hsa041141.14754744
35Lysine degradation_Homo sapiens_hsa003101.14198229
36Circadian rhythm_Homo sapiens_hsa047101.12836827
37Long-term depression_Homo sapiens_hsa047301.10913579
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05157419
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04553438
40Serotonergic synapse_Homo sapiens_hsa047261.04142895
41Cholinergic synapse_Homo sapiens_hsa047251.03724232
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01914293
43RNA transport_Homo sapiens_hsa030131.01359810
44Tight junction_Homo sapiens_hsa045301.00008694
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98663109
46Olfactory transduction_Homo sapiens_hsa047400.96733976
47Melanogenesis_Homo sapiens_hsa049160.95370569
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95163083
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94722087
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92878966
51RNA degradation_Homo sapiens_hsa030180.91260171
52cAMP signaling pathway_Homo sapiens_hsa040240.91115954
53Adherens junction_Homo sapiens_hsa045200.90968945
54TGF-beta signaling pathway_Homo sapiens_hsa043500.87138642
55Regulation of autophagy_Homo sapiens_hsa041400.85783396
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84981125
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84971796
58Salivary secretion_Homo sapiens_hsa049700.83633980
59mRNA surveillance pathway_Homo sapiens_hsa030150.83379020
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83221684
61Colorectal cancer_Homo sapiens_hsa052100.82788138
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81761553
63Gap junction_Homo sapiens_hsa045400.81207220
64Dorso-ventral axis formation_Homo sapiens_hsa043200.80791927
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78345636
66Renin secretion_Homo sapiens_hsa049240.76558258
67Thyroid hormone synthesis_Homo sapiens_hsa049180.75078653
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73846015
69Ether lipid metabolism_Homo sapiens_hsa005650.73787865
70Calcium signaling pathway_Homo sapiens_hsa040200.71825789
71Cell cycle_Homo sapiens_hsa041100.71711601
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71617987
73Type II diabetes mellitus_Homo sapiens_hsa049300.67757065
74Vitamin B6 metabolism_Homo sapiens_hsa007500.67281776
75Gastric acid secretion_Homo sapiens_hsa049710.65757742
76Dilated cardiomyopathy_Homo sapiens_hsa054140.64581003
77Fatty acid metabolism_Homo sapiens_hsa012120.64332529
78Homologous recombination_Homo sapiens_hsa034400.63672980
79Alcoholism_Homo sapiens_hsa050340.62406807
80Long-term potentiation_Homo sapiens_hsa047200.57590710
81Mismatch repair_Homo sapiens_hsa034300.57499195
82Oxytocin signaling pathway_Homo sapiens_hsa049210.57221678
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56743415
84Glucagon signaling pathway_Homo sapiens_hsa049220.56586226
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55866538
86Inositol phosphate metabolism_Homo sapiens_hsa005620.51719608
87MicroRNAs in cancer_Homo sapiens_hsa052060.51712378
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48153071
89Estrogen signaling pathway_Homo sapiens_hsa049150.47761530
90Ovarian steroidogenesis_Homo sapiens_hsa049130.47366571
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45871293
92beta-Alanine metabolism_Homo sapiens_hsa004100.43283355
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42843029
94Fatty acid biosynthesis_Homo sapiens_hsa000610.41970017
95Nitrogen metabolism_Homo sapiens_hsa009100.41647681
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40831977
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40041471
98ErbB signaling pathway_Homo sapiens_hsa040120.39699931
99Collecting duct acid secretion_Homo sapiens_hsa049660.37835962
100ABC transporters_Homo sapiens_hsa020100.37759573

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