TP53BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.15981758
2nuclear pore organization (GO:0006999)5.09203741
3pore complex assembly (GO:0046931)5.00244362
4regulation of NFAT protein import into nucleus (GO:0051532)4.83668338
5regulation of nucleobase-containing compound transport (GO:0032239)4.67292169
6regulation of RNA export from nucleus (GO:0046831)4.59202926
7negative regulation of erythrocyte differentiation (GO:0045647)4.39197855
8regulation of vitamin D biosynthetic process (GO:0060556)4.36318127
9positive regulation of p38MAPK cascade (GO:1900745)3.61411830
10positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.58905842
11mitotic chromosome condensation (GO:0007076)3.49802532
12response to muramyl dipeptide (GO:0032495)3.45549002
13activation of MAPKKK activity (GO:0000185)3.40910979
14regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.37260864
15response to peptidoglycan (GO:0032494)3.35605431
16DNA unwinding involved in DNA replication (GO:0006268)3.33199391
17mitotic sister chromatid cohesion (GO:0007064)3.31800748
18trophoblast giant cell differentiation (GO:0060707)3.23322513
19cellular response to thyroid hormone stimulus (GO:0097067)3.21489870
20positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.17998452
21negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.10877504
22cellular protein complex localization (GO:0034629)3.08604636
23regulation of vitamin metabolic process (GO:0030656)3.06307067
24negative regulation of histone methylation (GO:0031061)3.05871946
25lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98481380
26positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.95231387
273-UTR-mediated mRNA stabilization (GO:0070935)2.94200330
28RNA stabilization (GO:0043489)2.93737903
29mRNA stabilization (GO:0048255)2.93737903
30regulation of early endosome to late endosome transport (GO:2000641)2.93277629
31regulation of podosome assembly (GO:0071801)2.89184655
32embryonic process involved in female pregnancy (GO:0060136)2.89102079
33histone H3-K9 demethylation (GO:0033169)2.88882345
34regulation of fever generation (GO:0031620)2.84458472
35histone lysine demethylation (GO:0070076)2.83788499
36regulation of p38MAPK cascade (GO:1900744)2.83381924
37histone H3-K36 demethylation (GO:0070544)2.79642082
38regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77237822
39dosage compensation (GO:0007549)2.76154053
40histone demethylation (GO:0016577)2.75624345
41regulation of mitotic spindle organization (GO:0060236)2.74007756
42osteoclast differentiation (GO:0030316)2.73469242
43protein export from nucleus (GO:0006611)2.69805123
44regulation of histone H3-K27 methylation (GO:0061085)2.69440346
45epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68658312
46regulation of T-helper 1 cell differentiation (GO:0045625)2.63364850
47NIK/NF-kappaB signaling (GO:0038061)2.61714408
48response to laminar fluid shear stress (GO:0034616)2.60476963
49histone H2B ubiquitination (GO:0033523)2.58136434
50positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.57422856
51cytoskeletal anchoring at plasma membrane (GO:0007016)2.54613241
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54133475
53negative regulation of interleukin-12 production (GO:0032695)2.53568709
54mRNA transcription (GO:0009299)2.52964436
55pre-miRNA processing (GO:0031054)2.51488082
56response to thyroid hormone (GO:0097066)2.51152243
57positive regulation of protein export from nucleus (GO:0046827)2.50728258
58protein localization to endosome (GO:0036010)2.48593563
59DNA topological change (GO:0006265)2.47395249
60modulation by symbiont of host cellular process (GO:0044068)2.45251842
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41861803
62oligosaccharide catabolic process (GO:0009313)2.39846727
63cytoplasmic mRNA processing body assembly (GO:0033962)2.39817935
64heterochromatin organization (GO:0070828)2.34239422
65regulation of heterotypic cell-cell adhesion (GO:0034114)2.33470160
66adherens junction assembly (GO:0034333)2.32727828
67glycosphingolipid catabolic process (GO:0046479)2.32342949
68protein dealkylation (GO:0008214)2.32138392
69protein demethylation (GO:0006482)2.32138392
70regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.31260782
71positive regulation of cellular amide metabolic process (GO:0034250)2.30933152
72positive regulation of chemokine biosynthetic process (GO:0045080)2.30820448
73monoubiquitinated protein deubiquitination (GO:0035520)2.30348252
74hippo signaling (GO:0035329)2.27426381
75regulation of interleukin-2 biosynthetic process (GO:0045076)2.26324170
76regulation of response to osmotic stress (GO:0047484)2.24432871
77trophectodermal cell differentiation (GO:0001829)2.23151650
78N-terminal protein amino acid acetylation (GO:0006474)2.22479167
79protein complex localization (GO:0031503)2.21734243
80positive regulation of nitric oxide biosynthetic process (GO:0045429)2.17920105
81positive regulation of heat generation (GO:0031652)2.17027773
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.16722230
83negative regulation of bone mineralization (GO:0030502)2.14466272
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.14227670
85branching involved in labyrinthine layer morphogenesis (GO:0060670)2.13945250
86negative regulation of NF-kappaB import into nucleus (GO:0042347)2.12858993
87cortical actin cytoskeleton organization (GO:0030866)2.12157082
88regulation of interleukin-8 biosynthetic process (GO:0045414)2.11446543
89activation of Rac GTPase activity (GO:0032863)2.09980803
90positive regulation of extracellular matrix organization (GO:1903055)2.09647986
91negative regulation of vascular permeability (GO:0043116)2.09418535
92sister chromatid segregation (GO:0000819)2.09049996
93establishment of endothelial barrier (GO:0061028)2.07816416
94cell-substrate adherens junction assembly (GO:0007045)2.07269209
95focal adhesion assembly (GO:0048041)2.07269209
96regulation of chromatin binding (GO:0035561)2.06609327
97ovulation (GO:0030728)2.05146760
98germinal center formation (GO:0002467)2.05101476
99negative regulation of transcription factor import into nucleus (GO:0042992)2.04737928
100nuclear envelope disassembly (GO:0051081)2.03943176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human6.14561372
2E2F7_22180533_ChIP-Seq_HELA_Human5.07342719
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.94436272
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.51281196
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63346565
6GATA1_22025678_ChIP-Seq_K562_Human2.62237799
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55078571
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41626155
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31145141
10CLOCK_20551151_ChIP-Seq_293T_Human2.30094401
11MYC_22102868_ChIP-Seq_BL_Human2.29174581
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13110082
13TCF7_22412390_ChIP-Seq_EML_Mouse2.11932213
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.10800241
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09763141
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04545149
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04545149
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04545149
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98649969
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96447591
21VDR_21846776_ChIP-Seq_THP-1_Human1.89884400
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89271837
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.87940494
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87559534
25* KDM2B_26808549_Chip-Seq_K562_Human1.86414851
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85318181
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84120233
28* KDM2B_26808549_Chip-Seq_DND41_Human1.83779965
29AR_21909140_ChIP-Seq_LNCAP_Human1.83390197
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80484159
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77707626
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75509388
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68667600
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.68347752
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67420966
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67019265
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.65329936
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63563051
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.63549055
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62616202
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61130128
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58227624
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57998635
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57846710
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55953357
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54664812
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53857513
48* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49939042
49SCL_19346495_ChIP-Seq_HPC-7_Human1.42514744
50* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42190934
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.41139954
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38771722
53GATA1_19941826_ChIP-Seq_K562_Human1.37489386
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35767580
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35053420
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34039180
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33465100
58NCOR1_26117541_ChIP-Seq_K562_Human1.31990646
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31528189
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29292882
61VDR_24763502_ChIP-Seq_THP-1_Human1.28462044
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.27284080
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.25368622
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21272235
65TFEB_21752829_ChIP-Seq_HELA_Human1.21221427
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20554032
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20554032
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17373637
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17037160
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16071776
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14135164
72CHD1_26751641_Chip-Seq_LNCaP_Human1.13904138
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13835877
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.13390807
75MAF_26560356_Chip-Seq_TH1_Human1.13261556
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09586813
77PU_27001747_Chip-Seq_BMDM_Mouse1.07880419
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07683020
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07571146
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04492424
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04373551
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03644049
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03121994
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.02950974
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02813851
86GATA2_19941826_ChIP-Seq_K562_Human1.02545395
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.00687450
88ATF3_27146783_Chip-Seq_COLON_Human0.99679184
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99436047
90VDR_24787735_ChIP-Seq_THP-1_Human0.95243740
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95168589
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94516299
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93150060
94SPI1_23127762_ChIP-Seq_K562_Human0.92546366
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92161896
96* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91771284
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91364885
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91288124
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89230757
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88830399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.29672769
2MP0010352_gastrointestinal_tract_polyps3.64908797
3MP0008057_abnormal_DNA_replication3.40266997
4MP0005076_abnormal_cell_differentiation2.94201205
5MP0009278_abnormal_bone_marrow2.91640269
6MP0002877_abnormal_melanocyte_morpholog2.88526285
7MP0003705_abnormal_hypodermis_morpholog2.77478398
8MP0003656_abnormal_erythrocyte_physiolo2.70205395
9MP0003300_gastrointestinal_ulcer2.67599022
10MP0003453_abnormal_keratinocyte_physiol2.48400908
11MP0005451_abnormal_body_composition2.37268964
12MP0004185_abnormal_adipocyte_glucose2.25356359
13MP0004510_myositis2.23111150
14MP0003091_abnormal_cell_migration2.07318946
15MP0005058_abnormal_lysosome_morphology2.03142178
16MP0005397_hematopoietic_system_phenotyp2.02501640
17MP0001545_abnormal_hematopoietic_system2.02501640
18MP0004808_abnormal_hematopoietic_stem1.94889961
19MP0003828_pulmonary_edema1.83046782
20MP0008004_abnormal_stomach_pH1.80968415
21MP0003436_decreased_susceptibility_to1.79322718
22MP0003950_abnormal_plasma_membrane1.78350479
23MP0001853_heart_inflammation1.77104020
24MP0004947_skin_inflammation1.76353974
25MP0003566_abnormal_cell_adhesion1.75086028
26MP0003111_abnormal_nucleus_morphology1.71328493
27MP0005666_abnormal_adipose_tissue1.62049683
28MP0009840_abnormal_foam_cell1.59958319
29MP0001730_embryonic_growth_arrest1.47660005
30MP0003221_abnormal_cardiomyocyte_apopto1.42478401
31MP0002009_preneoplasia1.41883757
32MP0003448_altered_tumor_morphology1.39557517
33MP0003690_abnormal_glial_cell1.36015704
34MP0005623_abnormal_meninges_morphology1.34390172
35MP0010307_abnormal_tumor_latency1.33879309
36MP0003077_abnormal_cell_cycle1.31431084
37MP0002998_abnormal_bone_remodeling1.29445237
38MP0005621_abnormal_cell_physiology1.28990700
39MP0004233_abnormal_muscle_weight1.28089797
40MP0000350_abnormal_cell_proliferation1.25484034
41MP0000858_altered_metastatic_potential1.20134099
42MP0004957_abnormal_blastocyst_morpholog1.18891888
43MP0001915_intracranial_hemorrhage1.17835764
44MP0003172_abnormal_lysosome_physiology1.14487905
45MP0005023_abnormal_wound_healing1.11950332
46MP0000733_abnormal_muscle_development1.11301398
47MP0002086_abnormal_extraembryonic_tissu1.10646083
48MP0001849_ear_inflammation1.10365328
49MP0008007_abnormal_cellular_replicative1.08586997
50MP0002148_abnormal_hypersensitivity_rea1.07967520
51MP0010630_abnormal_cardiac_muscle1.05888000
52MP0001851_eye_inflammation1.05371178
53MP0005248_abnormal_Harderian_gland1.04729394
54MP0003984_embryonic_growth_retardation1.04478920
55MP0001672_abnormal_embryogenesis/_devel1.04359052
56MP0005380_embryogenesis_phenotype1.04359052
57MP0001697_abnormal_embryo_size1.01337345
58MP0000428_abnormal_craniofacial_morphol1.00773572
59MP0009333_abnormal_splenocyte_physiolog1.00615199
60MP0008260_abnormal_autophagy1.00459137
61MP0002088_abnormal_embryonic_growth/wei0.99196301
62MP0003115_abnormal_respiratory_system0.96018631
63MP0002405_respiratory_system_inflammati0.93880145
64MP0002419_abnormal_innate_immunity0.93773254
65MP0002092_abnormal_eye_morphology0.92897350
66MP0002080_prenatal_lethality0.91008682
67MP0002084_abnormal_developmental_patter0.85647062
68MP0005000_abnormal_immune_tolerance0.84598390
69MP0002138_abnormal_hepatobiliary_system0.84281750
70MP0002332_abnormal_exercise_endurance0.83126546
71MP0005384_cellular_phenotype0.82932106
72MP0002697_abnormal_eye_size0.82265721
73MP0001216_abnormal_epidermal_layer0.81980860
74MP0003634_abnormal_glial_cell0.81494201
75MP0009384_cardiac_valve_regurgitation0.80367623
76MP0000313_abnormal_cell_death0.80261308
77MP0001346_abnormal_lacrimal_gland0.80215838
78MP0008932_abnormal_embryonic_tissue0.79822950
79MP0006082_CNS_inflammation0.79371661
80MP0005375_adipose_tissue_phenotype0.78852387
81MP0002925_abnormal_cardiovascular_devel0.78679336
82MP0005409_darkened_coat_color0.78251347
83MP0002085_abnormal_embryonic_tissue0.77487050
84MP0003075_altered_response_to0.77398573
85MP0010094_abnormal_chromosome_stability0.77355973
86MP0000343_altered_response_to0.76457190
87MP0003890_abnormal_embryonic-extraembry0.75390559
88MP0001727_abnormal_embryo_implantation0.73177820
89MP0009764_decreased_sensitivity_to0.71968045
90MP0000920_abnormal_myelination0.71865189
91MP0002396_abnormal_hematopoietic_system0.70971973
92MP0003943_abnormal_hepatobiliary_system0.70694740
93MP0004197_abnormal_fetal_growth/weight/0.70520105
94MP0009672_abnormal_birth_weight0.68823794
95MP0000432_abnormal_head_morphology0.67622266
96MP0002398_abnormal_bone_marrow0.66339479
97MP0010234_abnormal_vibrissa_follicle0.66281617
98MP0001784_abnormal_fluid_regulation0.62665227
99MP0009697_abnormal_copulation0.61985626
100MP0002452_abnormal_antigen_presenting0.61656009

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.18474499
2Neonatal hypoglycemia (HP:0001998)2.70862635
3Deep philtrum (HP:0002002)2.65548526
4Abnormal large intestine physiology (HP:0012700)2.54522115
5Bowel incontinence (HP:0002607)2.50089526
6Cerebral inclusion bodies (HP:0100314)2.43051138
7Syringomyelia (HP:0003396)2.42479592
8Spinal cord lesions (HP:0100561)2.42479592
9Abnormality of the distal phalanx of the thumb (HP:0009617)2.41411420
10Cortical dysplasia (HP:0002539)2.41294677
11Urethral obstruction (HP:0000796)2.36083904
12Acute myeloid leukemia (HP:0004808)2.31891801
13Neurofibrillary tangles (HP:0002185)2.29326272
14Hyperacusis (HP:0010780)2.27194169
15Missing ribs (HP:0000921)2.26633535
16Abnormality of liposaccharide metabolism (HP:0010968)2.23734310
17Abnormality of glycosphingolipid metabolism (HP:0004343)2.23734310
18Abnormality of glycolipid metabolism (HP:0010969)2.23734310
19Ankyloglossia (HP:0010296)2.22791925
20Long eyelashes (HP:0000527)2.14503802
21Dysmetric saccades (HP:0000641)2.09532045
22Subacute progressive viral hepatitis (HP:0006572)2.01412643
23Limited elbow extension (HP:0001377)1.97403808
24Abnormality of the calcaneus (HP:0008364)1.95806287
25Obstructive sleep apnea (HP:0002870)1.93900178
26Papillary thyroid carcinoma (HP:0002895)1.91909664
27Mitral valve prolapse (HP:0001634)1.91156464
28Interstitial pulmonary disease (HP:0006530)1.89429623
29Disproportionate tall stature (HP:0001519)1.88524252
30Relative macrocephaly (HP:0004482)1.86684618
31Germ cell neoplasia (HP:0100728)1.85808672
32Macroorchidism (HP:0000053)1.85508560
33Cubitus valgus (HP:0002967)1.85426253
34Increased nuchal translucency (HP:0010880)1.83924910
35Hammertoe (HP:0001765)1.83903894
36Neuronal loss in central nervous system (HP:0002529)1.83776620
37Insomnia (HP:0100785)1.81937241
38Patellar dislocation (HP:0002999)1.81535146
39Slow saccadic eye movements (HP:0000514)1.81329170
40Broad thumb (HP:0011304)1.80936980
41Metaphyseal cupping (HP:0003021)1.80163668
42Arnold-Chiari malformation (HP:0002308)1.79691349
43Heterotopia (HP:0002282)1.79528195
44Abnormality of oral frenula (HP:0000190)1.79258270
45Peripheral hypomyelination (HP:0007182)1.78458955
46Dyschromatopsia (HP:0007641)1.77773132
47Nuclear cataract (HP:0100018)1.77284458
48Disinhibition (HP:0000734)1.76994956
49Short middle phalanx of the 5th finger (HP:0004220)1.76836456
50Thoracolumbar scoliosis (HP:0002944)1.76603177
51Vertebral arch anomaly (HP:0008438)1.75936269
52Abnormality of the parietal bone (HP:0002696)1.75932867
53Large earlobe (HP:0009748)1.74458889
54Overgrowth (HP:0001548)1.73115489
55Termporal pattern (HP:0011008)1.71916663
56Insidious onset (HP:0003587)1.71916663
57Flared metaphyses (HP:0003015)1.70701818
58Abnormality of the columella (HP:0009929)1.70633073
59Broad face (HP:0000283)1.69806525
60Long palpebral fissure (HP:0000637)1.69104415
61Leiomyosarcoma (HP:0100243)1.67950131
62Uterine leiomyosarcoma (HP:0002891)1.67950131
63Deep palmar crease (HP:0006191)1.67909044
64Abnormality of the salivary glands (HP:0010286)1.67592990
65Segmental peripheral demyelination/remyelination (HP:0003481)1.67085474
66Vitreoretinal degeneration (HP:0000655)1.67057761
6711 pairs of ribs (HP:0000878)1.66837127
68Thin ribs (HP:0000883)1.66683719
69Ulnar bowing (HP:0003031)1.66092547
70Thoracic kyphosis (HP:0002942)1.65285907
71Obsessive-compulsive behavior (HP:0000722)1.63781715
72Myocardial infarction (HP:0001658)1.62667548
73Decreased motor nerve conduction velocity (HP:0003431)1.62666589
74Abnormality of the phalanges of the hallux (HP:0010057)1.61560594
75Mitral regurgitation (HP:0001653)1.61056484
76Upper motor neuron abnormality (HP:0002127)1.60056308
77Flat acetabular roof (HP:0003180)1.59568486
78Hyperparathyroidism (HP:0000843)1.59387278
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58082086
80Truncus arteriosus (HP:0001660)1.57946478
81Deviation of the thumb (HP:0009603)1.57317235
82Fatigue (HP:0012378)1.55860890
83Cystic hygroma (HP:0000476)1.54876059
84Thickened helices (HP:0000391)1.52675947
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52376592
86Vertebral compression fractures (HP:0002953)1.50773816
87Abnormality of the thoracic spine (HP:0100711)1.50232192
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.49903959
89Short 4th metacarpal (HP:0010044)1.49903959
90Supernumerary ribs (HP:0005815)1.49016299
91Radioulnar synostosis (HP:0002974)1.48392117
92Spondylolisthesis (HP:0003302)1.47862511
93Transitional cell carcinoma of the bladder (HP:0006740)1.47784432
94Broad phalanges of the hand (HP:0009768)1.47297497
95Overriding aorta (HP:0002623)1.47279698
96Narrow palate (HP:0000189)1.47185296
97Scanning speech (HP:0002168)1.45692338
98Neonatal short-limb short stature (HP:0008921)1.45316585
99Overlapping toe (HP:0001845)1.45023805
100Proximal placement of thumb (HP:0009623)1.44928256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.16201963
2IRAK33.87073046
3PRPF4B3.44095890
4RIPK12.43776729
5TAOK22.15250516
6TYRO32.00718203
7ICK2.00364977
8CAMK1G1.94413338
9MAP3K141.93942173
10CAMK1D1.91533778
11BRD41.87804904
12LATS21.86005068
13KSR21.69254982
14PDGFRA1.67291590
15TRIB31.45254864
16MOS1.41736199
17EEF2K1.37644284
18MTOR1.35268073
19IRAK21.31932901
20MAP3K101.26407494
21KSR11.25610099
22PDGFRB1.25150524
23CLK11.24636085
24MAP2K31.20144640
25DDR21.18636930
26SGK31.18502825
27CDK61.15771830
28MAP3K31.13195964
29STK101.13156539
30NME21.12661781
31SMG11.11873468
32MAP3K91.06537003
33IRAK11.06068755
34TAOK11.05488974
35MAP3K131.04982521
36MAP3K81.03432862
37MARK21.00770869
38CDK41.00139718
39SIK30.98883441
40MAP3K10.98456911
41BMX0.97060526
42MKNK10.93270646
43DMPK0.90036029
44PKN20.88039052
45EPHA20.87008946
46DYRK30.85113157
47NTRK10.83873967
48BMPR20.83099298
49SGK20.82235364
50TTK0.82084759
51MATK0.80854060
52MAP3K20.78675379
53RIPK40.77137917
54BRSK20.77136847
55LATS10.75431433
56FGFR40.73323918
57FGR0.73202942
58TTN0.73061010
59MAPK100.72922069
60MAP3K60.71276364
61MKNK20.67777874
62NLK0.67465280
63RAF10.67279281
64CHEK10.67256273
65SIK10.66865149
66WNK10.66420084
67MARK30.65155659
68TBK10.65095669
69MELK0.63316341
70PAK20.62489141
71JAK20.61239721
72CDC70.60935152
73MAP3K50.60752939
74CHUK0.60333783
75CSK0.60285579
76STK30.60095681
77ZAP700.58652457
78IRAK40.58107967
79YES10.56608198
80ALK0.56562904
81PIM10.56541336
82BRAF0.56398120
83TYK20.55163737
84EPHB10.54064431
85RET0.53757055
86CDC42BPA0.52575457
87RPS6KC10.52473939
88RPS6KL10.52473939
89PNCK0.51991169
90GRK70.51527032
91IKBKE0.49747117
92LRRK20.49550078
93SGK2230.48576063
94SGK4940.48576063
95FGFR30.48267583
96NEK90.46424222
97HIPK20.46168513
98SCYL20.42031856
99CDK90.40231935
100CDK20.39501087

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.73204602
2Chronic myeloid leukemia_Homo sapiens_hsa052202.35510512
3Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91676296
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.90307161
5TNF signaling pathway_Homo sapiens_hsa046681.89664250
6Acute myeloid leukemia_Homo sapiens_hsa052211.87843263
7Pancreatic cancer_Homo sapiens_hsa052121.81750183
8Osteoclast differentiation_Homo sapiens_hsa043801.80086142
9Renal cell carcinoma_Homo sapiens_hsa052111.78477494
10Bladder cancer_Homo sapiens_hsa052191.76582773
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66767421
12Non-small cell lung cancer_Homo sapiens_hsa052231.63118646
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.61792587
14Hepatitis B_Homo sapiens_hsa051611.59937653
15Thyroid cancer_Homo sapiens_hsa052161.59603557
16MicroRNAs in cancer_Homo sapiens_hsa052061.57973225
17Notch signaling pathway_Homo sapiens_hsa043301.55602472
18Prion diseases_Homo sapiens_hsa050201.55395061
19Adherens junction_Homo sapiens_hsa045201.54132577
20Endometrial cancer_Homo sapiens_hsa052131.48598734
21Malaria_Homo sapiens_hsa051441.44808322
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.44475327
23ErbB signaling pathway_Homo sapiens_hsa040121.41614166
24Prostate cancer_Homo sapiens_hsa052151.40141164
25B cell receptor signaling pathway_Homo sapiens_hsa046621.37339291
26Legionellosis_Homo sapiens_hsa051341.37024339
27VEGF signaling pathway_Homo sapiens_hsa043701.36830189
28Amoebiasis_Homo sapiens_hsa051461.33115930
29Other glycan degradation_Homo sapiens_hsa005111.31575707
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29595048
31Salmonella infection_Homo sapiens_hsa051321.27898687
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27045623
33Prolactin signaling pathway_Homo sapiens_hsa049171.26749241
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24700302
35Glioma_Homo sapiens_hsa052141.23915835
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22289279
37Colorectal cancer_Homo sapiens_hsa052101.18786714
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18102511
39Cell cycle_Homo sapiens_hsa041101.18093475
40Influenza A_Homo sapiens_hsa051641.17720749
41Measles_Homo sapiens_hsa051621.15745203
42mTOR signaling pathway_Homo sapiens_hsa041501.15300602
43Small cell lung cancer_Homo sapiens_hsa052221.13498457
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.11847240
45T cell receptor signaling pathway_Homo sapiens_hsa046601.11509316
46Hepatitis C_Homo sapiens_hsa051601.11473116
47HIF-1 signaling pathway_Homo sapiens_hsa040661.08628635
48Leishmaniasis_Homo sapiens_hsa051401.07249656
49Apoptosis_Homo sapiens_hsa042101.05792070
50FoxO signaling pathway_Homo sapiens_hsa040681.04546927
51Dorso-ventral axis formation_Homo sapiens_hsa043201.02657620
52Pertussis_Homo sapiens_hsa051331.01531573
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00891599
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00700464
55African trypanosomiasis_Homo sapiens_hsa051431.00575659
56Proteoglycans in cancer_Homo sapiens_hsa052050.98951517
57Viral carcinogenesis_Homo sapiens_hsa052030.96821466
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.94926864
59Shigellosis_Homo sapiens_hsa051310.93095903
60Toxoplasmosis_Homo sapiens_hsa051450.92785233
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.91458175
62mRNA surveillance pathway_Homo sapiens_hsa030150.87968997
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.87330612
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87286527
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87062273
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86383145
67HTLV-I infection_Homo sapiens_hsa051660.85536093
68Type II diabetes mellitus_Homo sapiens_hsa049300.83319341
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82721406
70Herpes simplex infection_Homo sapiens_hsa051680.82078931
71Tuberculosis_Homo sapiens_hsa051520.81701252
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.81667712
73Chemokine signaling pathway_Homo sapiens_hsa040620.81028444
74Choline metabolism in cancer_Homo sapiens_hsa052310.80865373
75Lysine degradation_Homo sapiens_hsa003100.79505395
76Inositol phosphate metabolism_Homo sapiens_hsa005620.78578908
77Insulin signaling pathway_Homo sapiens_hsa049100.78068505
78Lysosome_Homo sapiens_hsa041420.73093760
79Focal adhesion_Homo sapiens_hsa045100.72845020
80Estrogen signaling pathway_Homo sapiens_hsa049150.72092753
81Pathways in cancer_Homo sapiens_hsa052000.70404020
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.70325585
83Epstein-Barr virus infection_Homo sapiens_hsa051690.69196291
84MAPK signaling pathway_Homo sapiens_hsa040100.68804972
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66913580
86TGF-beta signaling pathway_Homo sapiens_hsa043500.63166256
87GnRH signaling pathway_Homo sapiens_hsa049120.62208142
88Sphingolipid metabolism_Homo sapiens_hsa006000.57540234
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56075539
90Circadian rhythm_Homo sapiens_hsa047100.55102416
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55098981
92Insulin resistance_Homo sapiens_hsa049310.54411345
93Melanoma_Homo sapiens_hsa052180.53665659
94Spliceosome_Homo sapiens_hsa030400.49401908
95Rap1 signaling pathway_Homo sapiens_hsa040150.49357456
96Long-term potentiation_Homo sapiens_hsa047200.49195359
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48393374
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46684655
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46591984
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46461227

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