TP53I11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)4.98471005
2vascular endothelial growth factor signaling pathway (GO:0038084)4.49444088
3semaphorin-plexin signaling pathway (GO:0071526)4.47818586
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.11503342
5basement membrane organization (GO:0071711)4.05233263
6planar cell polarity pathway involved in neural tube closure (GO:0090179)3.89817861
7lymph vessel development (GO:0001945)3.87965728
8lymphangiogenesis (GO:0001946)3.83985726
9axon extension involved in axon guidance (GO:0048846)3.75217652
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.75217652
11endothelial tube morphogenesis (GO:0061154)3.74203890
12morphogenesis of an endothelium (GO:0003159)3.74203890
13paraxial mesoderm development (GO:0048339)3.62727032
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.61469546
15cell migration in hindbrain (GO:0021535)3.48059030
16vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.46161410
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.44386208
18protein heterotrimerization (GO:0070208)3.35956875
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.30144933
20negative regulation of blood vessel endothelial cell migration (GO:0043537)3.29171382
21type B pancreatic cell proliferation (GO:0044342)3.28744778
22barbed-end actin filament capping (GO:0051016)3.27143558
23regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.18302295
24blood vessel maturation (GO:0001955)3.18262788
25ganglion development (GO:0061548)3.14146049
26atrioventricular valve morphogenesis (GO:0003181)3.12879298
27cell-cell junction maintenance (GO:0045217)3.11699402
28protein retention in ER lumen (GO:0006621)3.00239093
29hyaluronan catabolic process (GO:0030214)2.98714571
30axon extension (GO:0048675)2.95338296
31bone trabecula formation (GO:0060346)2.93772217
32pyrimidine nucleobase catabolic process (GO:0006208)2.87203175
33adherens junction assembly (GO:0034333)2.85944146
34Notch receptor processing (GO:0007220)2.83932015
35negative regulation of axon extension involved in axon guidance (GO:0048843)2.83539626
36endothelial cell chemotaxis (GO:0035767)2.82753658
37Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.82190166
38cell migration involved in heart development (GO:0060973)2.81012116
39neuron recognition (GO:0008038)2.79639726
40substrate-dependent cell migration (GO:0006929)2.78761920
41negative regulation of chondrocyte differentiation (GO:0032331)2.76474092
42endothelial cell differentiation (GO:0045446)2.75170080
43stress fiber assembly (GO:0043149)2.72349977
44regulation of establishment of planar polarity (GO:0090175)2.69614135
45cytoskeletal anchoring at plasma membrane (GO:0007016)2.67952189
46glomerular filtration (GO:0003094)2.67678335
47Notch signaling involved in heart development (GO:0061314)2.67259755
48neuron projection extension (GO:1990138)2.67050173
49tooth mineralization (GO:0034505)2.65186796
50calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59034668
51ventricular trabecula myocardium morphogenesis (GO:0003222)2.58804259
52cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.56785154
53regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.55833164
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54830192
55endothelial cell morphogenesis (GO:0001886)2.52129960
56negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.51656602
57epithelial cell-cell adhesion (GO:0090136)2.51264607
58establishment of monopolar cell polarity (GO:0061162)2.48754335
59establishment or maintenance of monopolar cell polarity (GO:0061339)2.48754335
60negative regulation of axon guidance (GO:1902668)2.48318571
61neuron remodeling (GO:0016322)2.47679750
62regulation of axon extension involved in axon guidance (GO:0048841)2.45235477
63layer formation in cerebral cortex (GO:0021819)2.45139083
64cAMP biosynthetic process (GO:0006171)2.44913701
65dendritic spine morphogenesis (GO:0060997)2.44641924
66renal filtration (GO:0097205)2.43943791
67regulation of blood vessel endothelial cell migration (GO:0043535)2.43616381
68cell junction maintenance (GO:0034331)2.43475782
69response to water (GO:0009415)2.43390718
70aorta morphogenesis (GO:0035909)2.41061973
71axonal fasciculation (GO:0007413)2.40148531
72blood vessel endothelial cell migration (GO:0043534)2.40047483
73negative regulation of endothelial cell migration (GO:0010596)2.39382940
74regulation of synapse maturation (GO:0090128)2.38905903
75regulation of glomerular filtration (GO:0003093)2.38039621
76negative regulation of cell size (GO:0045792)2.36246825
77angiogenesis involved in wound healing (GO:0060055)2.34730169
78skin morphogenesis (GO:0043589)2.33940487
79protein targeting to plasma membrane (GO:0072661)2.33466871
80adherens junction organization (GO:0034332)2.33356176
81negative regulation of cartilage development (GO:0061037)2.33107948
82convergent extension (GO:0060026)2.30520333
83cell-substrate adherens junction assembly (GO:0007045)2.30170680
84focal adhesion assembly (GO:0048041)2.30170680
85endodermal cell differentiation (GO:0035987)2.30123118
86ear development (GO:0043583)2.29945497
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.29460126
88positive regulation of protein kinase C signaling (GO:0090037)2.28843855
89negative regulation of glial cell proliferation (GO:0060253)2.27829660
90collagen metabolic process (GO:0032963)2.26962965
91regulation of axon guidance (GO:1902667)2.26951753
92cochlea morphogenesis (GO:0090103)2.26498465
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.26331036
94establishment of apical/basal cell polarity (GO:0035089)2.26233315
95regulation of T-helper 2 cell differentiation (GO:0045628)2.26156267
96positive regulation of receptor recycling (GO:0001921)2.25081212
97camera-type eye morphogenesis (GO:0048593)2.24184854
98patterning of blood vessels (GO:0001569)2.24090352
99respiratory system process (GO:0003016)2.24039272
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.22887805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.33190300
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02302270
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96312453
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69650997
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66602829
6LXR_22292898_ChIP-Seq_THP-1_Human2.59729953
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54974802
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.53621107
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44407392
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.42688077
11KDM2B_26808549_Chip-Seq_K562_Human2.41933590
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12132267
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.06758311
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.05408199
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01971096
16KDM2B_26808549_Chip-Seq_DND41_Human2.01277978
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01255789
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01209825
19RACK7_27058665_Chip-Seq_MCF-7_Human1.98382885
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89645579
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.88061142
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87688326
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85775591
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.84519498
25DROSHA_22980978_ChIP-Seq_HELA_Human1.80312251
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78766598
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75843343
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75843343
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75601095
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.73856790
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72152919
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69797588
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.69291171
34* CTCF_27219007_Chip-Seq_Bcells_Human1.68351975
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.67688790
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.63949743
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59744353
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57721195
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57082418
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55481488
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.55374839
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.52165766
43EZH2_22144423_ChIP-Seq_EOC_Human1.49865044
44TCF7_22412390_ChIP-Seq_EML_Mouse1.49730340
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.49135088
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.48333931
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45196762
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44546753
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43627423
50CLOCK_20551151_ChIP-Seq_293T_Human1.42599054
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.39390119
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37702694
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.35275391
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34950014
55SMC4_20622854_ChIP-Seq_HELA_Human1.34571047
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33879069
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33396968
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33093552
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32338471
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32061963
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31631611
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.31412030
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30505357
64P68_20966046_ChIP-Seq_HELA_Human1.30390815
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28749311
66* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28252086
67VDR_21846776_ChIP-Seq_THP-1_Human1.27828968
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27513022
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.27163626
70CREB1_26743006_Chip-Seq_LNCaP_Human1.26455138
71TP53_22127205_ChIP-Seq_IMR90_Human1.26330621
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23927607
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18082221
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13430377
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.13132901
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.11832151
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10150259
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.09834013
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09652962
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09456488
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09088717
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08652238
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08637139
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07433011
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.06803505
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05512150
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05383992
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04644637
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04087988
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03211386
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02907981
92TP53_23651856_ChIP-Seq_MEFs_Mouse1.01968607
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01303904
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99333998
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98635370
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98334783
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97323216
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95882805
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95266292
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94669821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.68258975
2MP0003705_abnormal_hypodermis_morpholog4.09271779
3MP0008438_abnormal_cutaneous_collagen3.76594244
4MP0003279_aneurysm3.35718811
5MP0001879_abnormal_lymphatic_vessel3.35612870
6MP0004272_abnormal_basement_membrane3.32249394
7MP0005409_darkened_coat_color2.98476795
8MP0005503_abnormal_tendon_morphology2.48559423
9MP0010030_abnormal_orbit_morphology2.43585333
10MP0000767_abnormal_smooth_muscle2.35505073
11MP0004858_abnormal_nervous_system2.35159907
12MP0005257_abnormal_intraocular_pressure2.34126384
13MP0001958_emphysema2.31999075
14MP0005275_abnormal_skin_tensile2.19336402
15MP0003566_abnormal_cell_adhesion1.96293340
16MP0001849_ear_inflammation1.94880617
17MP0009384_cardiac_valve_regurgitation1.92532637
18MP0002653_abnormal_ependyma_morphology1.90820657
19MP0000751_myopathy1.78173775
20MP0003828_pulmonary_edema1.75257983
21MP0005167_abnormal_blood-brain_barrier1.72760238
22MP0002295_abnormal_pulmonary_circulatio1.67305725
23MP0004859_abnormal_synaptic_plasticity1.63669739
24MP0002249_abnormal_larynx_morphology1.52945711
25MP0000778_abnormal_nervous_system1.52687162
26MP0000049_abnormal_middle_ear1.46280316
27MP0005508_abnormal_skeleton_morphology1.46169492
28MP0002254_reproductive_system_inflammat1.45001559
29MP0000013_abnormal_adipose_tissue1.43023990
30MP0006054_spinal_hemorrhage1.37343908
31MP0002822_catalepsy1.32839197
32MP0005595_abnormal_vascular_smooth1.31460651
33MP0003091_abnormal_cell_migration1.30856802
34MP0001542_abnormal_bone_strength1.29652208
35MP0001348_abnormal_lacrimal_gland1.29193668
36MP0009053_abnormal_anal_canal1.25368552
37MP0005499_abnormal_olfactory_system1.17146160
38MP0005394_taste/olfaction_phenotype1.17146160
39MP0004782_abnormal_surfactant_physiolog1.16318967
40MP0002108_abnormal_muscle_morphology1.12682767
41MP0000750_abnormal_muscle_regeneration1.11306557
42MP0003942_abnormal_urinary_system1.11096544
43MP0000534_abnormal_ureter_morphology1.10820048
44MP0002796_impaired_skin_barrier1.09152047
45MP0003303_peritoneal_inflammation1.07399861
46MP0002932_abnormal_joint_morphology1.04669275
47MP0002896_abnormal_bone_mineralization1.04200069
48MP0004510_myositis1.04147944
49MP0001614_abnormal_blood_vessel1.02244697
50MP0000003_abnormal_adipose_tissue1.01313237
51MP0003115_abnormal_respiratory_system0.98684681
52MP0003329_amyloid_beta_deposits0.96165363
53MP0005390_skeleton_phenotype0.95288619
54MP0005623_abnormal_meninges_morphology0.93835053
55MP0002925_abnormal_cardiovascular_devel0.93441385
56MP0001299_abnormal_eye_distance/0.92820203
57MP0005377_hearing/vestibular/ear_phenot0.92091280
58MP0003878_abnormal_ear_physiology0.92091280
59MP0002751_abnormal_autonomic_nervous0.92002385
60MP0005083_abnormal_biliary_tract0.91317784
61MP0005248_abnormal_Harderian_gland0.90889154
62MP0003283_abnormal_digestive_organ0.90085396
63MP0004270_analgesia0.87981914
64MP0003948_abnormal_gas_homeostasis0.87719250
65MP0002127_abnormal_cardiovascular_syste0.87689385
66MP0005058_abnormal_lysosome_morphology0.87457173
67MP0008789_abnormal_olfactory_epithelium0.87208452
68MP0003300_gastrointestinal_ulcer0.86453129
69MP0002116_abnormal_craniofacial_bone0.86161418
70MP0008260_abnormal_autophagy0.85348275
71MP0003724_increased_susceptibility_to0.84087577
72MP0002089_abnormal_postnatal_growth/wei0.82234449
73MP0000537_abnormal_urethra_morphology0.82000375
74MP0002128_abnormal_blood_circulation0.81396813
75MP0002933_joint_inflammation0.79385914
76MP0002092_abnormal_eye_morphology0.79132134
77MP0003861_abnormal_nervous_system0.78114593
78MP0003935_abnormal_craniofacial_develop0.76823920
79MP0003123_paternal_imprinting0.76082466
80MP0000462_abnormal_digestive_system0.75653880
81MP0003119_abnormal_digestive_system0.75371421
82MP0003385_abnormal_body_wall0.74981159
83MP0004133_heterotaxia0.74256585
84MP0001915_intracranial_hemorrhage0.72540525
85MP0006138_congestive_heart_failure0.71651354
86MP0005501_abnormal_skin_physiology0.70269222
87MP0003191_abnormal_cellular_cholesterol0.70155938
88MP0002184_abnormal_innervation0.70148483
89MP0005076_abnormal_cell_differentiation0.70085493
90MP0005388_respiratory_system_phenotype0.68994102
91MP0002133_abnormal_respiratory_system0.68994102
92MP0000465_gastrointestinal_hemorrhage0.68370537
93MP0000428_abnormal_craniofacial_morphol0.67961720
94MP0003122_maternal_imprinting0.67612056
95MP0001175_abnormal_lung_morphology0.66867933
96MP0002697_abnormal_eye_size0.66173474
97MP0001270_distended_abdomen0.65589931
98MP0000955_abnormal_spinal_cord0.65490913
99MP0000733_abnormal_muscle_development0.63722850
100MP0000249_abnormal_blood_vessel0.63294068

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.18957975
2Protrusio acetabuli (HP:0003179)4.94542343
3Cerebral aneurysm (HP:0004944)4.03605737
4Broad metatarsal (HP:0001783)3.98565206
5Nonimmune hydrops fetalis (HP:0001790)3.66725426
6Lymphangioma (HP:0100764)3.66532646
7Vascular tortuosity (HP:0004948)3.50744420
8Aortic aneurysm (HP:0004942)3.44069000
9Shallow orbits (HP:0000586)3.43844931
10Arterial tortuosity (HP:0005116)3.23032800
11Aortic dissection (HP:0002647)3.12937331
12Spinal rigidity (HP:0003306)3.10777750
13Bladder diverticulum (HP:0000015)3.08229207
14Wrist flexion contracture (HP:0001239)3.05624521
15Abnormality of dentin (HP:0010299)3.00727216
16Cervical subluxation (HP:0003308)3.00663118
17Increased variability in muscle fiber diameter (HP:0003557)2.92536010
18Obstructive sleep apnea (HP:0002870)2.87386891
19Hypoventilation (HP:0002791)2.83800317
20Ankle contracture (HP:0006466)2.83337837
21Distal upper limb amyotrophy (HP:0007149)2.78594916
22Upper limb amyotrophy (HP:0009129)2.78594916
23Genu recurvatum (HP:0002816)2.77555520
24Increased connective tissue (HP:0009025)2.64797688
25Blue sclerae (HP:0000592)2.64645659
26Hyperacusis (HP:0010780)2.58290864
27Peritonitis (HP:0002586)2.57188937
28Hand muscle atrophy (HP:0009130)2.56384962
29Soft skin (HP:0000977)2.56331221
30Disproportionate tall stature (HP:0001519)2.50677903
31Thin bony cortex (HP:0002753)2.49545961
32Difficulty climbing stairs (HP:0003551)2.46278014
33Joint laxity (HP:0001388)2.44251974
34Aneurysm (HP:0002617)2.42547012
35Abnormality of skeletal muscle fiber size (HP:0012084)2.37286018
36Overgrowth (HP:0001548)2.36472748
37Atrophic scars (HP:0001075)2.33996316
38Fragile skin (HP:0001030)2.31425920
39Mildly elevated creatine phosphokinase (HP:0008180)2.29517807
40Bowel diverticulosis (HP:0005222)2.26318841
41Dilatation of the ascending aorta (HP:0005111)2.24105146
42Long palpebral fissure (HP:0000637)2.23137553
43Turricephaly (HP:0000262)2.19609100
44Type 1 muscle fiber predominance (HP:0003803)2.18398718
45Abnormality of the pulmonary veins (HP:0011718)2.12498798
46Buphthalmos (HP:0000557)2.12482544
47Wormian bones (HP:0002645)2.11745558
48Mitral valve prolapse (HP:0001634)2.11057674
49Slender build (HP:0001533)2.09845197
50Wide anterior fontanel (HP:0000260)2.07564133
51Long toe (HP:0010511)2.06759706
52Mitral regurgitation (HP:0001653)2.03958410
53Congenital glaucoma (HP:0001087)2.03688747
54Hyperextensible skin (HP:0000974)2.02254975
55Ectopia lentis (HP:0001083)2.00051368
56Hydroureter (HP:0000072)1.99231863
57Distal lower limb amyotrophy (HP:0008944)1.98374496
58Neonatal short-limb short stature (HP:0008921)1.98276540
59Esophageal varix (HP:0002040)1.90662480
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90500068
61Short 4th metacarpal (HP:0010044)1.90500068
62Distal lower limb muscle weakness (HP:0009053)1.89588755
63Metaphyseal cupping (HP:0003021)1.85755496
64Vitreoretinal degeneration (HP:0000655)1.84227579
65Anomalous pulmonary venous return (HP:0010772)1.83782889
66Broad face (HP:0000283)1.78272066
67Abnormality of the lower motor neuron (HP:0002366)1.78199011
68Neoplasm of the heart (HP:0100544)1.77378659
69Asymmetry of the thorax (HP:0001555)1.75855227
70Protruding ear (HP:0000411)1.75480416
71Joint stiffness (HP:0001387)1.75104095
72Abnormal vertebral ossification (HP:0100569)1.72679818
73Atelectasis (HP:0100750)1.71702332
74Skull defect (HP:0001362)1.70056466
75Lower limb amyotrophy (HP:0007210)1.68172160
76Vertebral compression fractures (HP:0002953)1.68165958
77Supranuclear gaze palsy (HP:0000605)1.66653032
78Venous abnormality (HP:0002624)1.66505633
79Renal duplication (HP:0000075)1.66483740
80Inguinal hernia (HP:0000023)1.66168793
81Venous insufficiency (HP:0005293)1.64320183
82Visceral angiomatosis (HP:0100761)1.64277614
83Arnold-Chiari malformation (HP:0002308)1.62651101
84Long eyelashes (HP:0000527)1.62565869
85Down-sloping shoulders (HP:0200021)1.62404476
86Generalized hypotonia (HP:0001290)1.61910718
87Biconcave vertebral bodies (HP:0004586)1.61691689
88Broad long bones (HP:0005622)1.61176566
89Coronal craniosynostosis (HP:0004440)1.59195435
90Abnormality of the intervertebral disk (HP:0005108)1.58117959
91Ulnar bowing (HP:0003031)1.58110792
92Bronchomalacia (HP:0002780)1.56444388
93Abnormality of the peritoneum (HP:0002585)1.56436802
94Thin ribs (HP:0000883)1.56408393
95Hemangiomatosis (HP:0007461)1.56222429
96Short nail (HP:0001799)1.54386694
97Follicular hyperkeratosis (HP:0007502)1.53478219
98Lumbar hyperlordosis (HP:0002938)1.53375287
99Spontaneous hematomas (HP:0007420)1.52066682
100Precocious puberty (HP:0000826)1.51698744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.55935489
2TRIB33.37270991
3KDR3.12877614
4RIPK12.98893993
5EPHB22.91506388
6SIK12.57131219
7TESK12.55935704
8PDGFRA2.32997406
9ERN12.32042765
10NTRK12.19162949
11PKN21.97183953
12MARK21.95600115
13PRKD21.89326845
14EPHB11.84888610
15ICK1.84623376
16EPHA21.67500488
17MAP3K111.66318093
18PRKD31.60720060
19RPS6KA21.57259867
20DDR21.55389667
21MYLK1.51657368
22DYRK1B1.50046193
23MARK11.44613759
24CDC42BPA1.39679119
25SMG11.35448241
26PTK21.34868827
27TYRO31.32021173
28FER1.28710324
29MAP3K61.25238322
30FGFR41.23884031
31MAP3K101.19084100
32TAOK11.17646178
33PRKG21.16473267
34LIMK11.11544300
35EPHA31.06990036
36PTK61.06706170
37PAK41.05489664
38PRPF4B1.02024058
39TESK21.00729630
40TGFBR21.00646250
41TTN0.99342588
42SIK30.98978557
43FES0.98071851
44MAP3K70.97465199
45DYRK20.95588654
46PDGFRB0.88207392
47SIK20.87044854
48MTOR0.80946917
49PTK2B0.77825915
50DMPK0.74181993
51MAP2K30.73525679
52CDK120.72025045
53DYRK30.71389856
54ZAP700.69741231
55CSK0.69354926
56KSR20.69217202
57GRK50.68977359
58RPS6KL10.68852911
59RPS6KC10.68852911
60STK380.63288253
61MAPK70.63143740
62RET0.62404403
63GRK60.61951908
64PRKD10.60952863
65EEF2K0.58080577
66MET0.56717185
67MAP3K10.56203177
68BMX0.55768480
69MAP2K40.55580137
70LATS20.54251710
71ARAF0.53726473
72PAK20.53177553
73RPS6KA60.51401920
74TNK20.51388628
75ROCK20.50661937
76MAP3K30.49310717
77ERBB20.47988144
78MAP3K90.47308369
79CAMK10.46646714
80CDK50.46109435
81SGK4940.46030866
82SGK2230.46030866
83MATK0.44780407
84PRKCH0.44264210
85SRC0.43589550
86CDK190.42949669
87CAMKK10.42296033
88LRRK20.42257546
89EPHA40.41071595
90GRK10.40233516
91FLT30.39639746
92DAPK30.39333721
93CDK11A0.38854974
94PRKCZ0.37993080
95CDK150.35817989
96MAP2K70.35293947
97PDPK10.34869200
98TAOK20.34136606
99ROCK10.34011071
100CDK180.33247112

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043303.11144683
2Axon guidance_Homo sapiens_hsa043602.26754391
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09064685
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.93562632
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84594906
6Focal adhesion_Homo sapiens_hsa045101.76716328
7ECM-receptor interaction_Homo sapiens_hsa045121.72342158
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.56895045
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54844652
10VEGF signaling pathway_Homo sapiens_hsa043701.50335422
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49404258
12Rap1 signaling pathway_Homo sapiens_hsa040151.49142710
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43423884
14Phospholipase D signaling pathway_Homo sapiens_hsa040721.40797618
15Adherens junction_Homo sapiens_hsa045201.35004755
16Amoebiasis_Homo sapiens_hsa051461.32130137
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31283438
18Gap junction_Homo sapiens_hsa045401.30313682
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29807934
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29703510
21Dilated cardiomyopathy_Homo sapiens_hsa054141.27459536
22Synaptic vesicle cycle_Homo sapiens_hsa047211.27321288
23Vibrio cholerae infection_Homo sapiens_hsa051101.26915913
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.26295365
25Basal cell carcinoma_Homo sapiens_hsa052171.24404138
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23422425
27Melanogenesis_Homo sapiens_hsa049161.21155455
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18274175
29Endocytosis_Homo sapiens_hsa041441.17428509
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15970441
31Chronic myeloid leukemia_Homo sapiens_hsa052201.15501540
32Estrogen signaling pathway_Homo sapiens_hsa049151.15225658
33Endometrial cancer_Homo sapiens_hsa052131.13166167
34Renal cell carcinoma_Homo sapiens_hsa052111.11888968
35Proteoglycans in cancer_Homo sapiens_hsa052051.11657363
36Tight junction_Homo sapiens_hsa045301.10914744
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.09793727
38Cocaine addiction_Homo sapiens_hsa050301.08935471
39Other glycan degradation_Homo sapiens_hsa005111.06542798
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06203648
41Cholinergic synapse_Homo sapiens_hsa047251.05775083
42Choline metabolism in cancer_Homo sapiens_hsa052311.04224031
43Protein digestion and absorption_Homo sapiens_hsa049741.01679857
44GnRH signaling pathway_Homo sapiens_hsa049120.98284903
45Bladder cancer_Homo sapiens_hsa052190.97840039
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97589756
47Acute myeloid leukemia_Homo sapiens_hsa052210.96324813
48Glioma_Homo sapiens_hsa052140.96160917
49Hedgehog signaling pathway_Homo sapiens_hsa043400.96058677
50ErbB signaling pathway_Homo sapiens_hsa040120.95403576
51Hippo signaling pathway_Homo sapiens_hsa043900.94180775
52Ras signaling pathway_Homo sapiens_hsa040140.94004828
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92920009
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91668298
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91325795
56Pathways in cancer_Homo sapiens_hsa052000.90268707
57Salmonella infection_Homo sapiens_hsa051320.89659890
58Colorectal cancer_Homo sapiens_hsa052100.89393694
59Prolactin signaling pathway_Homo sapiens_hsa049170.89042106
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.88190263
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86986886
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82381565
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79642997
64Insulin signaling pathway_Homo sapiens_hsa049100.79533749
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79273446
66Thyroid cancer_Homo sapiens_hsa052160.79104677
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78503682
68MAPK signaling pathway_Homo sapiens_hsa040100.78501987
69AMPK signaling pathway_Homo sapiens_hsa041520.78108782
70Lysosome_Homo sapiens_hsa041420.77656846
71Glutamatergic synapse_Homo sapiens_hsa047240.77016033
72Prion diseases_Homo sapiens_hsa050200.76910486
73MicroRNAs in cancer_Homo sapiens_hsa052060.76247638
74Gastric acid secretion_Homo sapiens_hsa049710.75492014
75Oxytocin signaling pathway_Homo sapiens_hsa049210.74776753
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73774667
77Pancreatic cancer_Homo sapiens_hsa052120.73694327
78Dopaminergic synapse_Homo sapiens_hsa047280.73679778
79Malaria_Homo sapiens_hsa051440.73663228
80Wnt signaling pathway_Homo sapiens_hsa043100.73544168
81mTOR signaling pathway_Homo sapiens_hsa041500.73474503
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73220895
83Shigellosis_Homo sapiens_hsa051310.71657641
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70655408
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70299194
86Platelet activation_Homo sapiens_hsa046110.69602140
87cAMP signaling pathway_Homo sapiens_hsa040240.69542774
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.68146498
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66461075
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65966882
91Phagosome_Homo sapiens_hsa041450.65467766
92Non-small cell lung cancer_Homo sapiens_hsa052230.64732602
93Prostate cancer_Homo sapiens_hsa052150.63025797
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62218489
95GABAergic synapse_Homo sapiens_hsa047270.61814137
96Morphine addiction_Homo sapiens_hsa050320.60864061
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60341151
98Chemokine signaling pathway_Homo sapiens_hsa040620.59877180
99Hepatitis C_Homo sapiens_hsa051600.59686530
100Melanoma_Homo sapiens_hsa052180.59335653

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