TP53INP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.07285530
2synaptic vesicle maturation (GO:0016188)4.78158200
3glutamate secretion (GO:0014047)4.49457122
4sodium ion export (GO:0071436)4.43078020
5cellular potassium ion homeostasis (GO:0030007)4.36240903
6synaptic vesicle exocytosis (GO:0016079)4.16721826
7central nervous system myelination (GO:0022010)4.10702069
8axon ensheathment in central nervous system (GO:0032291)4.10702069
9regulation of synaptic vesicle exocytosis (GO:2000300)3.98106536
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82426584
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.79737596
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62687746
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60719301
14L-amino acid import (GO:0043092)3.49560578
15cerebellar granule cell differentiation (GO:0021707)3.40674090
16regulation of synaptic vesicle transport (GO:1902803)3.39039731
17locomotory exploration behavior (GO:0035641)3.37025268
18positive regulation of synapse maturation (GO:0090129)3.32301861
19neuronal ion channel clustering (GO:0045161)3.28513062
20regulation of neuronal synaptic plasticity (GO:0048168)3.18948562
21potassium ion homeostasis (GO:0055075)3.14509337
22cell communication by electrical coupling (GO:0010644)3.13355567
23neurotransmitter secretion (GO:0007269)3.13294164
24amino acid import (GO:0043090)3.11366294
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10815127
26cellular sodium ion homeostasis (GO:0006883)3.10356420
27regulation of ARF protein signal transduction (GO:0032012)3.07664426
28neurotransmitter-gated ion channel clustering (GO:0072578)3.02423761
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00993782
30potassium ion import (GO:0010107)2.98633428
31neuronal action potential propagation (GO:0019227)2.98103579
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90886661
33cytoskeletal anchoring at plasma membrane (GO:0007016)2.85969849
34neuromuscular process controlling balance (GO:0050885)2.80188340
35regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79974882
36regulation of glutamate receptor signaling pathway (GO:1900449)2.78420938
37positive regulation of dendritic spine development (GO:0060999)2.72401284
38layer formation in cerebral cortex (GO:0021819)2.67893436
39positive regulation of neurotransmitter secretion (GO:0001956)2.67861795
40cell communication involved in cardiac conduction (GO:0086065)2.66993829
41ionotropic glutamate receptor signaling pathway (GO:0035235)2.66542844
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.62870850
43regulation of synapse maturation (GO:0090128)2.62820032
44regulation of synaptic plasticity (GO:0048167)2.62646448
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57742762
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56980816
47exploration behavior (GO:0035640)2.54887986
48vocalization behavior (GO:0071625)2.53352455
49negative regulation of dendrite morphogenesis (GO:0050774)2.52648549
50positive regulation of neurotransmitter transport (GO:0051590)2.52281346
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50241797
52regulation of voltage-gated calcium channel activity (GO:1901385)2.50014554
53neurotransmitter transport (GO:0006836)2.50010630
54myelin maintenance (GO:0043217)2.46317541
55regulation of synapse structural plasticity (GO:0051823)2.43910382
56regulation of neurotransmitter secretion (GO:0046928)2.43119288
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42416716
58postsynaptic membrane organization (GO:0001941)2.39374270
59protein-lipid complex assembly (GO:0065005)2.35799852
60synaptic transmission, glutamatergic (GO:0035249)2.35412885
61neuromuscular process controlling posture (GO:0050884)2.33992942
62long-term memory (GO:0007616)2.33660294
63cellular response to catecholamine stimulus (GO:0071870)2.32516916
64cellular response to monoamine stimulus (GO:0071868)2.32516916
65protein localization to synapse (GO:0035418)2.32236707
66positive regulation of membrane potential (GO:0045838)2.31408681
67regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31115468
68sarcoplasmic reticulum calcium ion transport (GO:0070296)2.28120566
69regulation of neurotransmitter levels (GO:0001505)2.27534615
70regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.24371278
71positive regulation of Rap GTPase activity (GO:0032854)2.23659488
72regulation of cholesterol esterification (GO:0010872)2.22990177
73negative regulation of inclusion body assembly (GO:0090084)2.21338856
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19832119
75cellular response to epinephrine stimulus (GO:0071872)2.19503687
76regulation of dendritic spine development (GO:0060998)2.18354606
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.17010417
78regulation of cholesterol homeostasis (GO:2000188)2.16744631
79regulation of female receptivity (GO:0045924)2.16405179
80regulation of vesicle fusion (GO:0031338)2.16307443
81regulation of postsynaptic membrane potential (GO:0060078)2.15232629
82cell-cell junction maintenance (GO:0045217)2.14791329
83regulation of sodium ion transmembrane transporter activity (GO:2000649)2.14577073
84regulation of neurotransmitter transport (GO:0051588)2.14085762
85positive regulation of dendrite development (GO:1900006)2.13889726
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13021916
87regulation of dendritic spine morphogenesis (GO:0061001)2.11617266
88regulation of sodium ion transmembrane transport (GO:1902305)2.11611073
89activation of protein kinase A activity (GO:0034199)2.11467097
90cerebellar Purkinje cell differentiation (GO:0021702)2.10896792
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09531000
92plasma lipoprotein particle assembly (GO:0034377)2.09262274
93membrane depolarization during action potential (GO:0086010)2.08190897
94detection of calcium ion (GO:0005513)2.07917023
95regulation of T-helper 2 cell differentiation (GO:0045628)2.07908491
96synaptic vesicle endocytosis (GO:0048488)2.07126462
97response to monoamine (GO:0071867)2.06972901
98response to catecholamine (GO:0071869)2.06972901
99positive regulation of steroid metabolic process (GO:0045940)2.06391822
100glutamate receptor signaling pathway (GO:0007215)2.06384956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.07912290
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.88839478
3DROSHA_22980978_ChIP-Seq_HELA_Human2.43539606
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42258304
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23455732
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.18595122
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.02007907
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00093360
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95148048
10MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94800782
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94574988
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82093007
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82093007
14* KDM2B_26808549_Chip-Seq_K562_Human1.80899855
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76203704
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76044627
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75438029
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71897431
19REST_21632747_ChIP-Seq_MESCs_Mouse1.71555371
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71499856
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.71251683
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63740407
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61444556
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60943731
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60399938
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.58634233
27* LXR_22292898_ChIP-Seq_THP-1_Human1.56802802
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48948934
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47611092
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42590374
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41877325
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.40923591
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35426652
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.34834366
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34778432
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.34698443
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33247127
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22286220
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.21554942
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.21404223
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20726924
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19826751
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19398351
44CTCF_27219007_Chip-Seq_Bcells_Human1.17061242
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.16810292
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16614328
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16522661
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16320536
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.14506100
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13374498
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12906380
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.10565729
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.10216702
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09749962
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09574252
56* KDM2B_26808549_Chip-Seq_DND41_Human1.09355599
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07785915
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06555961
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06304926
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05883992
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04993823
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04799849
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.03968526
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.00004496
65TET1_21490601_ChIP-Seq_MESCs_Mouse0.99895799
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98574411
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97207468
68TBX20_22328084_ChIP-Seq_HEART_Mouse0.96480587
69TBX20_22080862_ChIP-Seq_HEART_Mouse0.96480587
70SMC4_20622854_ChIP-Seq_HELA_Human0.96338742
71CLOCK_20551151_ChIP-Seq_293T_Human0.95323148
72GATA1_19941827_ChIP-Seq_MEL_Mouse0.93799109
73TCF7_22412390_ChIP-Seq_EML_Mouse0.93007529
74CREB1_26743006_Chip-Seq_LNCaP_Human0.91725556
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91465585
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90902499
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89750160
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88417022
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87640477
80RING1B_27294783_Chip-Seq_NPCs_Mouse0.87368311
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86562823
82RACK7_27058665_Chip-Seq_MCF-7_Human0.86159722
83* GATA2_21666600_ChIP-Seq_HMVEC_Human0.83490185
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83218934
85PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82297450
86OCT4_19829295_ChIP-Seq_ESCs_Human0.82259170
87* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82106743
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81511441
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81382097
90GATA1_19941826_ChIP-Seq_K562_Human0.80971919
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79139816
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79081514
93AR_21572438_ChIP-Seq_LNCaP_Human0.78903003
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78420342
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78071414
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77104284
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76613364
98TP53_23651856_ChIP-Seq_MEFs_Mouse0.75387452
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75257424
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73867166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.73456103
2MP0004270_analgesia3.87840700
3MP0005423_abnormal_somatic_nervous3.30822827
4MP0003880_abnormal_central_pattern2.86345944
5MP0002064_seizures2.82261808
6MP0003635_abnormal_synaptic_transmissio2.80662202
7MP0003879_abnormal_hair_cell2.75483183
8MP0003690_abnormal_glial_cell2.71070449
9MP0003329_amyloid_beta_deposits2.60766233
10MP0003303_peritoneal_inflammation2.52929358
11MP0000920_abnormal_myelination2.48013770
12MP0009840_abnormal_foam_cell2.40427387
13MP0002063_abnormal_learning/memory/cond2.22842033
14MP0009745_abnormal_behavioral_response2.20227765
15MP0001486_abnormal_startle_reflex2.18352493
16MP0009046_muscle_twitch2.13251799
17MP0002734_abnormal_mechanical_nocicepti2.12831414
18MP0004510_myositis2.12798581
19MP0001501_abnormal_sleep_pattern2.09055892
20MP0008569_lethality_at_weaning2.07042696
21MP0009780_abnormal_chondrocyte_physiolo2.04688150
22MP0002272_abnormal_nervous_system2.04489438
23MP0003172_abnormal_lysosome_physiology1.97053020
24MP0005167_abnormal_blood-brain_barrier1.89197195
25MP0003075_altered_response_to1.87227963
26MP0005058_abnormal_lysosome_morphology1.83206815
27MP0002139_abnormal_hepatobiliary_system1.79617296
28MP0003123_paternal_imprinting1.78193582
29MP0002572_abnormal_emotion/affect_behav1.77215954
30MP0003633_abnormal_nervous_system1.75192786
31MP0000604_amyloidosis1.70925125
32MP0005409_darkened_coat_color1.70223088
33MP0005670_abnormal_white_adipose1.63452471
34MP0003122_maternal_imprinting1.57035113
35MP0001970_abnormal_pain_threshold1.53759510
36MP0002735_abnormal_chemical_nociception1.50396700
37MP0001440_abnormal_grooming_behavior1.41054583
38MP0003634_abnormal_glial_cell1.37665070
39MP0004885_abnormal_endolymph1.37084159
40MP0003631_nervous_system_phenotype1.36657918
41MP0004130_abnormal_muscle_cell1.35379588
42MP0002733_abnormal_thermal_nociception1.34418129
43MP0001968_abnormal_touch/_nociception1.30266913
44MP0008004_abnormal_stomach_pH1.29284708
45MP0003191_abnormal_cellular_cholesterol1.27598588
46MP0000751_myopathy1.25179947
47MP0002067_abnormal_sensory_capabilities1.19961630
48MP0005166_decreased_susceptibility_to1.16059450
49MP0001502_abnormal_circadian_rhythm1.14524670
50MP0002332_abnormal_exercise_endurance1.14376917
51MP0004811_abnormal_neuron_physiology1.14157118
52MP0002066_abnormal_motor_capabilities/c1.09690182
53MP0005535_abnormal_body_temperature1.07771678
54MP0002557_abnormal_social/conspecific_i1.07670159
55MP0000747_muscle_weakness1.06855059
56MP0005646_abnormal_pituitary_gland1.06638881
57MP0002822_catalepsy1.06543129
58MP0005451_abnormal_body_composition1.04395441
59MP0005365_abnormal_bile_salt1.03739382
60MP0003632_abnormal_nervous_system1.03629513
61MP0002229_neurodegeneration1.00472851
62MP0008874_decreased_physiological_sensi0.99767088
63MP0000955_abnormal_spinal_cord0.97463238
64MP0002882_abnormal_neuron_morphology0.95786501
65MP0005666_abnormal_adipose_tissue0.94896610
66MP0004924_abnormal_behavior0.94367504
67MP0005386_behavior/neurological_phenoty0.94367504
68MP0010329_abnormal_lipoprotein_level0.90570134
69MP0003045_fibrosis0.89353163
70MP0004043_abnormal_pH_regulation0.88023670
71MP0000778_abnormal_nervous_system0.82108001
72MP0004742_abnormal_vestibular_system0.81516972
73MP0002089_abnormal_postnatal_growth/wei0.79692811
74MP0001984_abnormal_olfaction0.77634271
75MP0003183_abnormal_peptide_metabolism0.77154644
76MP0002909_abnormal_adrenal_gland0.77114923
77MP0005375_adipose_tissue_phenotype0.76093752
78MP0002118_abnormal_lipid_homeostasis0.74288025
79MP0003195_calcinosis0.73365040
80MP0004484_altered_response_of0.73076631
81MP0001905_abnormal_dopamine_level0.71292797
82MP0003868_abnormal_feces_composition0.69521954
83MP0005410_abnormal_fertilization0.69372730
84MP0005448_abnormal_energy_balance0.69003942
85MP0005165_increased_susceptibility_to0.68843156
86MP0004036_abnormal_muscle_relaxation0.68376805
87MP0001348_abnormal_lacrimal_gland0.68238623
88MP0006082_CNS_inflammation0.68230190
89MP0004087_abnormal_muscle_fiber0.67478363
90MP0001765_abnormal_ion_homeostasis0.67308120
91MP0001963_abnormal_hearing_physiology0.64207236
92MP0002971_abnormal_brown_adipose0.63821700
93MP0002972_abnormal_cardiac_muscle0.63352911
94MP0003436_decreased_susceptibility_to0.62271177
95MP0006276_abnormal_autonomic_nervous0.62177580
96MP0000749_muscle_degeneration0.59086406
97MP0002736_abnormal_nociception_after0.58137196
98MP0002152_abnormal_brain_morphology0.57838283
99MP0003300_gastrointestinal_ulcer0.55626228
100MP0002998_abnormal_bone_remodeling0.55202630

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.95008623
2Neurofibrillary tangles (HP:0002185)4.57457303
3Supranuclear gaze palsy (HP:0000605)4.12208647
4Action tremor (HP:0002345)3.85254929
5Ankle clonus (HP:0011448)3.60677104
6Cerebral inclusion bodies (HP:0100314)3.56699060
7Focal motor seizures (HP:0011153)3.52014768
8Abnormality of binocular vision (HP:0011514)3.48147900
9Diplopia (HP:0000651)3.48147900
10Obstructive sleep apnea (HP:0002870)3.45793573
11Febrile seizures (HP:0002373)3.32444713
12Deep venous thrombosis (HP:0002625)3.28319641
13Focal seizures (HP:0007359)3.27906616
14Epileptic encephalopathy (HP:0200134)3.17679639
15Bundle branch block (HP:0011710)2.97307351
16Amyloidosis (HP:0011034)2.93749878
17Peripheral hypomyelination (HP:0007182)2.93085308
18Atonic seizures (HP:0010819)2.89442472
19Mutism (HP:0002300)2.75418557
20Hyporeflexia of lower limbs (HP:0002600)2.71984827
21Spastic gait (HP:0002064)2.70346560
22Postural instability (HP:0002172)2.62412977
23Dysmetria (HP:0001310)2.60582216
24Muscle fiber splitting (HP:0003555)2.57997594
25Neuronal loss in central nervous system (HP:0002529)2.54922488
26Systemic lupus erythematosus (HP:0002725)2.52509985
27Urinary bladder sphincter dysfunction (HP:0002839)2.51972147
28Ventricular fibrillation (HP:0001663)2.47822440
29Torticollis (HP:0000473)2.41207189
30Progressive cerebellar ataxia (HP:0002073)2.39228631
31Abnormal eating behavior (HP:0100738)2.36708186
32Generalized tonic-clonic seizures (HP:0002069)2.33110866
33Sudden death (HP:0001699)2.26316274
34Complement deficiency (HP:0004431)2.25396173
35Apathy (HP:0000741)2.24876646
36Visual hallucinations (HP:0002367)2.22002579
37Axonal loss (HP:0003447)2.20633801
38Asymmetric septal hypertrophy (HP:0001670)2.20340120
39Absence seizures (HP:0002121)2.20187874
40Syncope (HP:0001279)2.17546856
41Rigidity (HP:0002063)2.16256633
42Depression (HP:0000716)2.14783328
43Heart block (HP:0012722)2.11631590
44Papilledema (HP:0001085)2.10779069
45Foot dorsiflexor weakness (HP:0009027)2.09407138
46Intention tremor (HP:0002080)2.08078369
47Akinesia (HP:0002304)2.07230908
48Truncal ataxia (HP:0002078)2.06970654
49Focal dystonia (HP:0004373)2.06945278
50Abnormal atrioventricular conduction (HP:0005150)2.05721317
51Scanning speech (HP:0002168)2.04858597
52Dysostosis multiplex (HP:0000943)2.03437708
53Glomerulonephritis (HP:0000099)2.03243118
54Rapidly progressive (HP:0003678)2.00970675
55Diminished motivation (HP:0000745)2.00701940
56Nuclear cataract (HP:0100018)2.00350201
57Craniofacial dystonia (HP:0012179)1.99398568
58Decreased motor nerve conduction velocity (HP:0003431)1.98322294
59Lower limb muscle weakness (HP:0007340)1.98274184
60Spastic tetraparesis (HP:0001285)1.96656017
61Abnormality of the foot musculature (HP:0001436)1.94103618
62Hyperparathyroidism (HP:0000843)1.94031993
63Tetraplegia (HP:0002445)1.93836185
64Joint hemorrhage (HP:0005261)1.92660962
65Dialeptic seizures (HP:0011146)1.92494969
66Lower limb amyotrophy (HP:0007210)1.90927722
67Onion bulb formation (HP:0003383)1.90230292
68Distal lower limb muscle weakness (HP:0009053)1.90138234
69Hypercortisolism (HP:0001578)1.89945812
70Increased circulating renin level (HP:0000848)1.88389489
71Hemiplegia (HP:0002301)1.86721559
72Status epilepticus (HP:0002133)1.86268659
73Cerebral aneurysm (HP:0004944)1.85257931
74Annular pancreas (HP:0001734)1.85162731
75Ventricular arrhythmia (HP:0004308)1.84219323
76Clonus (HP:0002169)1.84112646
77Anxiety (HP:0000739)1.83408299
78Abnormality of the periventricular white matter (HP:0002518)1.82622993
79Urinary glycosaminoglycan excretion (HP:0003541)1.80817317
80Mucopolysacchariduria (HP:0008155)1.80817317
81Sleep apnea (HP:0010535)1.79774308
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79720779
83Bradykinesia (HP:0002067)1.79054004
84Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77639678
85Abnormality of polysaccharide metabolism (HP:0011012)1.77639678
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77639678
87Urinary urgency (HP:0000012)1.76350293
88Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75672156
89Prolonged QT interval (HP:0001657)1.73613714
90Upper limb amyotrophy (HP:0009129)1.72871078
91Distal upper limb amyotrophy (HP:0007149)1.72871078
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71697861
93Dementia (HP:0000726)1.71637382
94Exercise-induced myalgia (HP:0003738)1.71302891
95Alacrima (HP:0000522)1.70945381
96Stereotypic behavior (HP:0000733)1.70847147
97Difficulty running (HP:0009046)1.69807447
98Epileptiform EEG discharges (HP:0011182)1.69070990
99Frequent falls (HP:0002359)1.66725792
100Hypoalphalipoproteinemia (HP:0003233)1.66563874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.39906331
2MARK13.01718937
3NTRK32.95582900
4PAK62.46635126
5EPHA42.44528787
6DAPK22.36316631
7PRPF4B2.18833492
8UHMK12.08422190
9MAP3K91.93199592
10TYRO31.82480675
11NTRK21.71277859
12PRKD31.71061555
13LATS21.69632434
14ICK1.67835888
15RIPK41.59893968
16KSR21.55290952
17SIK21.49243102
18SGK2231.48806548
19SGK4941.48806548
20MINK11.42852581
21MARK21.40924372
22CAMKK11.40059198
23SGK31.35752620
24DDR21.33959134
25WNK11.32168807
26NTRK11.31522168
27SGK21.26885897
28STK381.23339772
29PHKG21.18953194
30PHKG11.18953194
31DMPK1.18926365
32MAPK121.16534790
33CDK51.15057334
34PDPK11.13630865
35TRIB31.09331287
36CAMK1G1.08829219
37CAMK1D1.06095403
38MAP3K111.04679392
39ARAF1.02616121
40CAMK11.01722647
41PDK11.00957861
42FGFR40.99168192
43MAP3K10.99105228
44PKN10.98584736
45PINK10.97446320
46CDK120.95576412
47MAP3K20.91568779
48ERN10.89700355
49IRAK30.89676852
50PDGFRA0.86216798
51TESK10.85611726
52TAOK20.85152244
53SGK10.83330994
54PRKCH0.82603209
55PAK30.80531918
56FGFR30.80099703
57CDC42BPA0.80043345
58LMTK20.78854730
59CAMK2B0.78848214
60MAPK100.73905905
61NEK60.73577848
62CAMK40.71976114
63TAOK10.70313207
64DYRK1B0.70168063
65CAMK2G0.69291760
66PDK20.67605130
67CDK150.66975955
68PRKCG0.65647108
69MOS0.65492738
70MAP3K130.62796818
71MAP3K30.62505481
72STK110.60949434
73CDK180.60885412
74CDK11A0.60619872
75AKT30.60522436
76DYRK1A0.60487729
77GRK50.59221713
78CAMK2A0.59149396
79OBSCN0.59129345
80CAMK2D0.58984521
81SIK10.58503986
82CDK140.57120094
83PRKD10.56614292
84RET0.56545828
85ROCK20.56255392
86TTN0.56186106
87CASK0.55999783
88RPS6KA20.55753101
89PRKCZ0.52705411
90IRAK20.51775970
91RPS6KA30.51593720
92PIK3CA0.51298758
93ERBB20.51050256
94MAPK40.49726967
95PRKAA20.49396676
96KSR10.49202276
97ALK0.48982389
98ROCK10.48200261
99JAK20.46428904
100PRKG20.44706560

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.46148108
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06209587
3Long-term potentiation_Homo sapiens_hsa047201.96822321
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92062282
5Nicotine addiction_Homo sapiens_hsa050331.83082911
6Insulin secretion_Homo sapiens_hsa049111.68603622
7Amphetamine addiction_Homo sapiens_hsa050311.58664647
8Glutamatergic synapse_Homo sapiens_hsa047241.56820717
9GABAergic synapse_Homo sapiens_hsa047271.56337821
10Circadian entrainment_Homo sapiens_hsa047131.53640797
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47675264
12Gastric acid secretion_Homo sapiens_hsa049711.44718422
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44602772
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43741003
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43478982
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42551624
17Morphine addiction_Homo sapiens_hsa050321.41766902
18Cocaine addiction_Homo sapiens_hsa050301.40048600
19Prion diseases_Homo sapiens_hsa050201.33472505
20Bile secretion_Homo sapiens_hsa049761.32650723
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31611192
22Histidine metabolism_Homo sapiens_hsa003401.23939364
23Dopaminergic synapse_Homo sapiens_hsa047281.22578411
24GnRH signaling pathway_Homo sapiens_hsa049121.22569677
25Salivary secretion_Homo sapiens_hsa049701.21375545
26Renin secretion_Homo sapiens_hsa049241.19873066
27Complement and coagulation cascades_Homo sapiens_hsa046101.18464989
28cAMP signaling pathway_Homo sapiens_hsa040241.15915765
29Oxytocin signaling pathway_Homo sapiens_hsa049211.12819862
30PPAR signaling pathway_Homo sapiens_hsa033201.10438060
31Cholinergic synapse_Homo sapiens_hsa047251.08257373
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02569523
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.02307304
34Fatty acid biosynthesis_Homo sapiens_hsa000611.02198109
35Type II diabetes mellitus_Homo sapiens_hsa049301.00888573
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00667862
37Estrogen signaling pathway_Homo sapiens_hsa049151.00287628
38Calcium signaling pathway_Homo sapiens_hsa040200.96799654
39Other glycan degradation_Homo sapiens_hsa005110.96467817
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96055116
41VEGF signaling pathway_Homo sapiens_hsa043700.94468608
42Dilated cardiomyopathy_Homo sapiens_hsa054140.88269367
43Arginine biosynthesis_Homo sapiens_hsa002200.87922604
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86152717
45Pancreatic secretion_Homo sapiens_hsa049720.85432027
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.84820342
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83838740
48Thyroid hormone synthesis_Homo sapiens_hsa049180.83283699
49Arginine and proline metabolism_Homo sapiens_hsa003300.82843291
50ErbB signaling pathway_Homo sapiens_hsa040120.82550577
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81973941
52Glioma_Homo sapiens_hsa052140.79516564
53Circadian rhythm_Homo sapiens_hsa047100.79313573
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.78654649
55Long-term depression_Homo sapiens_hsa047300.78192692
56Mineral absorption_Homo sapiens_hsa049780.76467737
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.75861689
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75645065
59Vibrio cholerae infection_Homo sapiens_hsa051100.75621394
60Gap junction_Homo sapiens_hsa045400.75273515
61Amoebiasis_Homo sapiens_hsa051460.72400365
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72371775
63MAPK signaling pathway_Homo sapiens_hsa040100.71873609
64Pertussis_Homo sapiens_hsa051330.68887044
65Insulin signaling pathway_Homo sapiens_hsa049100.68785954
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68713999
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.68253142
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67320311
69Serotonergic synapse_Homo sapiens_hsa047260.67098862
70Dorso-ventral axis formation_Homo sapiens_hsa043200.67094467
71Phenylalanine metabolism_Homo sapiens_hsa003600.65361752
72Collecting duct acid secretion_Homo sapiens_hsa049660.65205350
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.63654660
74African trypanosomiasis_Homo sapiens_hsa051430.62654164
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62627515
76Inositol phosphate metabolism_Homo sapiens_hsa005620.62593264
77Lysosome_Homo sapiens_hsa041420.61135040
78Endocytosis_Homo sapiens_hsa041440.60949230
79Glucagon signaling pathway_Homo sapiens_hsa049220.60786812
80Osteoclast differentiation_Homo sapiens_hsa043800.60678132
81Choline metabolism in cancer_Homo sapiens_hsa052310.59395528
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58376843
83Rap1 signaling pathway_Homo sapiens_hsa040150.57968758
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57669401
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55935736
86Sphingolipid metabolism_Homo sapiens_hsa006000.55773189
87Melanogenesis_Homo sapiens_hsa049160.54128489
88Cardiac muscle contraction_Homo sapiens_hsa042600.53788388
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53222472
90Salmonella infection_Homo sapiens_hsa051320.51773197
91Insulin resistance_Homo sapiens_hsa049310.51056675
92Renal cell carcinoma_Homo sapiens_hsa052110.50667979
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49954150
94beta-Alanine metabolism_Homo sapiens_hsa004100.47357320
95mTOR signaling pathway_Homo sapiens_hsa041500.46727045
96AMPK signaling pathway_Homo sapiens_hsa041520.46172904
97TNF signaling pathway_Homo sapiens_hsa046680.46100584
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46040397
99Ras signaling pathway_Homo sapiens_hsa040140.45934937
100Axon guidance_Homo sapiens_hsa043600.45500918

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