TP53RK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)6.20087167
2proteasome assembly (GO:0043248)5.07266686
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.89575397
4regulation of mitochondrial translation (GO:0070129)4.66151742
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.46910082
6nucleotide transmembrane transport (GO:1901679)4.42999522
7pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.31248246
8spliceosomal snRNP assembly (GO:0000387)4.29609258
9pyrimidine nucleotide catabolic process (GO:0006244)4.11606240
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.09465421
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.09465421
12positive regulation of mitochondrial fission (GO:0090141)4.06180346
13pseudouridine synthesis (GO:0001522)4.04670376
14protein-cofactor linkage (GO:0018065)4.01194853
15pyrimidine dimer repair (GO:0006290)3.97522420
16iron-sulfur cluster assembly (GO:0016226)3.67201966
17metallo-sulfur cluster assembly (GO:0031163)3.67201966
18DNA double-strand break processing (GO:0000729)3.58989044
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52376401
20protein import into peroxisome matrix (GO:0016558)3.50976273
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50917443
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47675363
23peptidyl-histidine modification (GO:0018202)3.46002963
24ribosome assembly (GO:0042255)3.44408449
257-methylguanosine RNA capping (GO:0009452)3.39919053
26RNA capping (GO:0036260)3.39919053
27mitochondrial RNA metabolic process (GO:0000959)3.38223640
28rRNA modification (GO:0000154)3.30033591
29protein localization to peroxisome (GO:0072662)3.29465358
30protein targeting to peroxisome (GO:0006625)3.29465358
31establishment of protein localization to peroxisome (GO:0072663)3.29465358
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.28773787
33DNA integration (GO:0015074)3.27066042
34chaperone-mediated protein transport (GO:0072321)3.26125126
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25947763
36replication fork processing (GO:0031297)3.22286735
37intracellular protein transmembrane import (GO:0044743)3.22098067
38deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21130943
39histone mRNA metabolic process (GO:0008334)3.18738529
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18111842
41protein targeting to mitochondrion (GO:0006626)3.16770977
42RNA methylation (GO:0001510)3.16758698
43protein localization to mitochondrion (GO:0070585)3.12601890
44establishment of integrated proviral latency (GO:0075713)3.11333948
45peptidyl-arginine omega-N-methylation (GO:0035247)3.08635978
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07780592
47peroxisomal transport (GO:0043574)3.07756250
48platelet dense granule organization (GO:0060155)3.07515766
49ubiquinone biosynthetic process (GO:0006744)3.06664647
50* tRNA processing (GO:0008033)3.06297456
51DNA deamination (GO:0045006)3.06241303
52establishment of viral latency (GO:0019043)3.03648194
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00381318
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00150576
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.00150576
56NADH dehydrogenase complex assembly (GO:0010257)3.00150576
57rRNA methylation (GO:0031167)2.98210637
58regulation of cellular amino acid metabolic process (GO:0006521)2.96516335
59protein complex biogenesis (GO:0070271)2.95864917
60mitochondrial respiratory chain complex assembly (GO:0033108)2.94489688
612-deoxyribonucleotide metabolic process (GO:0009394)2.90033650
62negative regulation of ligase activity (GO:0051352)2.89581623
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89581623
64* tRNA metabolic process (GO:0006399)2.88614130
65deoxyribonucleotide catabolic process (GO:0009264)2.87271549
66termination of RNA polymerase II transcription (GO:0006369)2.85569974
67peptidyl-arginine N-methylation (GO:0035246)2.84935918
68peptidyl-arginine methylation (GO:0018216)2.84935918
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84356946
70base-excision repair, AP site formation (GO:0006285)2.83963943
71establishment of protein localization to mitochondrion (GO:0072655)2.83466088
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.83029870
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83029870
74tRNA modification (GO:0006400)2.82780351
75deoxyribose phosphate catabolic process (GO:0046386)2.81553268
76ubiquinone metabolic process (GO:0006743)2.81162326
77deoxyribose phosphate biosynthetic process (GO:0046385)2.80945162
782-deoxyribonucleotide biosynthetic process (GO:0009265)2.80945162
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80874430
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80874430
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80874430
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80393962
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79907071
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79907071
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.79189222
86protein deneddylation (GO:0000338)2.79159672
87deoxyribose phosphate metabolic process (GO:0019692)2.77226943
88amino acid salvage (GO:0043102)2.75406025
89L-methionine salvage (GO:0071267)2.75406025
90L-methionine biosynthetic process (GO:0071265)2.75406025
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74325984
92cullin deneddylation (GO:0010388)2.73789039
93histone arginine methylation (GO:0034969)2.73640914
94regulation of helicase activity (GO:0051095)2.73412027
95chromatin remodeling at centromere (GO:0031055)2.72547214
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72439494
97signal transduction involved in DNA damage checkpoint (GO:0072422)2.72439494
98deoxyribonucleotide metabolic process (GO:0009262)2.72197049
99double-strand break repair via nonhomologous end joining (GO:0006303)2.71778225
100non-recombinational repair (GO:0000726)2.71778225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62560606
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.38528107
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77994304
4E2F7_22180533_ChIP-Seq_HELA_Human3.76420223
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.56275883
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.42865837
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.40321753
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39323731
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23865934
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13151929
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04694913
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03372206
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01645079
14VDR_23849224_ChIP-Seq_CD4+_Human2.94911156
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.89195267
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85028989
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72671780
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65560899
19* ELK1_19687146_ChIP-ChIP_HELA_Human2.63996519
20FOXP3_21729870_ChIP-Seq_TREG_Human2.63863191
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63644559
22GABP_19822575_ChIP-Seq_HepG2_Human2.58299274
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58098212
24DCP1A_22483619_ChIP-Seq_HELA_Human2.52572139
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39046386
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34463096
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31558691
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30561323
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.30147724
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25726523
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.20365232
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17463610
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.16442133
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13728658
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11268307
36IRF1_19129219_ChIP-ChIP_H3396_Human2.10263268
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08967003
38HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06398352
39* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99115041
40ZNF274_21170338_ChIP-Seq_K562_Hela1.98571546
41IGF1R_20145208_ChIP-Seq_DFB_Human1.97701266
42XRN2_22483619_ChIP-Seq_HELA_Human1.91965854
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91589887
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79658265
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76959972
46TTF2_22483619_ChIP-Seq_HELA_Human1.76643557
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.62712237
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60742590
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.59754103
50KDM5A_27292631_Chip-Seq_BREAST_Human1.58236082
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53017924
52CIITA_25753668_ChIP-Seq_RAJI_Human1.52697160
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51008360
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49405293
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49205557
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48630617
57MYC_18940864_ChIP-ChIP_HL60_Human1.47225924
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42027727
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.42007854
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38003147
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34742660
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34502641
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32294300
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30494424
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30443648
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30253086
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27706255
68* ELK1_22589737_ChIP-Seq_MCF10A_Human1.25447530
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24303751
70EWS_26573619_Chip-Seq_HEK293_Human1.22864183
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18009349
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14300145
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13491243
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07527005
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.07475617
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05778517
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01997754
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00057579
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99355159
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96624744
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94750267
82TFEB_21752829_ChIP-Seq_HELA_Human0.93488807
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92484909
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92203930
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91608965
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.87483561
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85619848
88TP53_22573176_ChIP-Seq_HFKS_Human0.85003703
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84883731
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84124393
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84086143
92SPI1_23547873_ChIP-Seq_NB4_Human0.83052654
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82701392
94FUS_26573619_Chip-Seq_HEK293_Human0.81970018
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80289934
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78585713
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78471519
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76821659
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.73009880
100ELF5_23300383_ChIP-Seq_T47D_Human0.72833419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.61888899
2MP0008058_abnormal_DNA_repair3.45675231
3MP0006082_CNS_inflammation3.37022011
4MP0008789_abnormal_olfactory_epithelium3.31718897
5MP0003693_abnormal_embryo_hatching3.22668072
6MP0008057_abnormal_DNA_replication2.69016358
7MP0002132_abnormal_respiratory_system2.66440769
8MP0003111_abnormal_nucleus_morphology2.58994395
9MP0001529_abnormal_vocalization2.58958055
10MP0002102_abnormal_ear_morphology2.48918836
11MP0005499_abnormal_olfactory_system2.47173726
12MP0005394_taste/olfaction_phenotype2.47173726
13MP0006292_abnormal_olfactory_placode2.38986871
14MP0003077_abnormal_cell_cycle2.36775632
15MP0005367_renal/urinary_system_phenotyp2.35886342
16MP0000516_abnormal_urinary_system2.35886342
17MP0002254_reproductive_system_inflammat2.26816004
18MP0003315_abnormal_perineum_morphology2.13740976
19MP0003786_premature_aging2.12606147
20MP0006035_abnormal_mitochondrial_morpho2.01324022
21MP0008932_abnormal_embryonic_tissue1.96422531
22MP0003186_abnormal_redox_activity1.80849609
23MP0004957_abnormal_blastocyst_morpholog1.73320930
24MP0003718_maternal_effect1.72274871
25MP0009697_abnormal_copulation1.66655570
26MP0006036_abnormal_mitochondrial_physio1.60031277
27MP0006276_abnormal_autonomic_nervous1.58655015
28MP0000372_irregular_coat_pigmentation1.56078906
29MP0003221_abnormal_cardiomyocyte_apopto1.54977753
30MP0001346_abnormal_lacrimal_gland1.54293997
31MP0006072_abnormal_retinal_apoptosis1.53842016
32MP0002095_abnormal_skin_pigmentation1.49786688
33MP0002160_abnormal_reproductive_system1.49395761
34MP0009384_cardiac_valve_regurgitation1.41061447
35MP0000358_abnormal_cell_content/1.40166209
36MP0000049_abnormal_middle_ear1.39701087
37MP0002736_abnormal_nociception_after1.38231975
38MP0002234_abnormal_pharynx_morphology1.33746408
39MP0001727_abnormal_embryo_implantation1.31730197
40MP0003806_abnormal_nucleotide_metabolis1.31157866
41MP0001293_anophthalmia1.28135103
42MP0008007_abnormal_cellular_replicative1.26814569
43MP0000613_abnormal_salivary_gland1.26679665
44MP0003121_genomic_imprinting1.24706399
45MP0005647_abnormal_sex_gland1.24663393
46MP0001764_abnormal_homeostasis1.18352521
47MP0000647_abnormal_sebaceous_gland1.16875520
48MP0002638_abnormal_pupillary_reflex1.15499948
49MP0005389_reproductive_system_phenotype1.13468656
50MP0000631_abnormal_neuroendocrine_gland1.10042459
51MP0001119_abnormal_female_reproductive1.09839284
52MP0001919_abnormal_reproductive_system1.09254774
53MP0005253_abnormal_eye_physiology1.08181091
54MP0001873_stomach_inflammation1.07021587
55MP0005187_abnormal_penis_morphology1.06656862
56MP0005248_abnormal_Harderian_gland1.02807844
57MP0002396_abnormal_hematopoietic_system1.00523801
58MP0002822_catalepsy0.99532888
59MP0000639_abnormal_adrenal_gland0.99027711
60MP0009333_abnormal_splenocyte_physiolog0.97961368
61MP0002837_dystrophic_cardiac_calcinosis0.97909867
62MP0005220_abnormal_exocrine_pancreas0.96679992
63MP0002751_abnormal_autonomic_nervous0.96573138
64MP0001545_abnormal_hematopoietic_system0.95847246
65MP0005397_hematopoietic_system_phenotyp0.95847246
66MP0002938_white_spotting0.95558693
67MP0004133_heterotaxia0.95414830
68MP0000313_abnormal_cell_death0.95167231
69MP0000465_gastrointestinal_hemorrhage0.94735109
70MP0000653_abnormal_sex_gland0.93166237
71MP0004147_increased_porphyrin_level0.92823812
72MP0002019_abnormal_tumor_incidence0.92068510
73MP0002233_abnormal_nose_morphology0.91224525
74MP0001984_abnormal_olfaction0.91219084
75MP0002277_abnormal_respiratory_mucosa0.89018166
76MP0003183_abnormal_peptide_metabolism0.88022050
77MP0002210_abnormal_sex_determination0.87736927
78MP0001929_abnormal_gametogenesis0.86848320
79MP0002282_abnormal_trachea_morphology0.85242608
80MP0008995_early_reproductive_senescence0.84803869
81MP0001145_abnormal_male_reproductive0.83130394
82MP0002177_abnormal_outer_ear0.82251456
83MP0000015_abnormal_ear_pigmentation0.82227140
84MP0008260_abnormal_autophagy0.81473580
85MP0005310_abnormal_salivary_gland0.80791890
86MP0000750_abnormal_muscle_regeneration0.80677660
87MP0005266_abnormal_metabolism0.80548579
88MP0005075_abnormal_melanosome_morpholog0.80430495
89MP0003385_abnormal_body_wall0.78923815
90MP0000350_abnormal_cell_proliferation0.76485476
91MP0005391_vision/eye_phenotype0.74944027
92MP0001905_abnormal_dopamine_level0.73899862
93MP0009046_muscle_twitch0.71859306
94MP0003698_abnormal_male_reproductive0.70701535
95MP0003937_abnormal_limbs/digits/tail_de0.70626886
96MP0001270_distended_abdomen0.70483996
97MP0002080_prenatal_lethality0.70314948
98MP0000371_diluted_coat_color0.67421199
99MP0001697_abnormal_embryo_size0.65944090
100MP0009765_abnormal_xenobiotic_induced0.65236747

Predicted human phenotypes

RankGene SetZ-score
1Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.76440424
2Abnormal protein N-linked glycosylation (HP:0012347)3.76440424
3Abnormal protein glycosylation (HP:0012346)3.76440424
4Abnormal glycosylation (HP:0012345)3.76440424
5Brushfield spots (HP:0001088)3.64571598
6Type I transferrin isoform profile (HP:0003642)3.40486337
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.34147757
8Abnormality of alanine metabolism (HP:0010916)3.34147757
9Hyperalaninemia (HP:0003348)3.34147757
10Abnormality of B cell number (HP:0010975)3.22688958
11Aplastic anemia (HP:0001915)3.20475344
12Hepatocellular necrosis (HP:0001404)3.09695549
13Increased CSF lactate (HP:0002490)2.98595989
14Increased serum lactate (HP:0002151)2.94718284
15Microvesicular hepatic steatosis (HP:0001414)2.93683832
16Acute necrotizing encephalopathy (HP:0006965)2.93065063
17Medial flaring of the eyebrow (HP:0010747)2.88096163
18Abnormal mitochondria in muscle tissue (HP:0008316)2.87172891
19Hyperglycinemia (HP:0002154)2.84361895
20Reduced antithrombin III activity (HP:0001976)2.84104818
21Acute encephalopathy (HP:0006846)2.80284357
22Mitochondrial inheritance (HP:0001427)2.78593809
23Lactic acidosis (HP:0003128)2.69080226
243-Methylglutaconic aciduria (HP:0003535)2.67921657
25Hepatic necrosis (HP:0002605)2.65974349
26Nephrogenic diabetes insipidus (HP:0009806)2.64451884
27Congenital primary aphakia (HP:0007707)2.64315429
28Medulloblastoma (HP:0002885)2.63857393
29B lymphocytopenia (HP:0010976)2.56852871
30Flat occiput (HP:0005469)2.54496864
31True hermaphroditism (HP:0010459)2.52088038
32Microretrognathia (HP:0000308)2.50281732
33Pancreatic fibrosis (HP:0100732)2.49450659
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47340305
35Poikiloderma (HP:0001029)2.47307115
36Methylmalonic acidemia (HP:0002912)2.44790667
37Adrenal hypoplasia (HP:0000835)2.43395395
38Epiphyseal stippling (HP:0010655)2.40758315
39Pancreatic cysts (HP:0001737)2.39378066
40Gait imbalance (HP:0002141)2.38314928
41Methylmalonic aciduria (HP:0012120)2.26049235
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22935705
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22935705
44Entropion (HP:0000621)2.22748898
45Colon cancer (HP:0003003)2.21363111
46Hypoproteinemia (HP:0003075)2.19413036
47Tubulointerstitial nephritis (HP:0001970)2.18031234
48Chromsome breakage (HP:0040012)2.17585432
49Increased serum pyruvate (HP:0003542)2.16794067
50Progressive macrocephaly (HP:0004481)2.16104812
51Abnormality of serum amino acid levels (HP:0003112)2.08245335
52Constricted visual fields (HP:0001133)2.05540740
53CNS demyelination (HP:0007305)2.04679883
54Cerebral edema (HP:0002181)2.03582704
55Decreased testicular size (HP:0008734)2.01645747
56Lipid accumulation in hepatocytes (HP:0006561)1.95835755
57Ependymoma (HP:0002888)1.95646879
58Progressive microcephaly (HP:0000253)1.91614976
59Abnormality of the astrocytes (HP:0100707)1.90612602
60Astrocytoma (HP:0009592)1.90612602
61Abnormality of the metopic suture (HP:0005556)1.90494007
62Retinal dysplasia (HP:0007973)1.90198554
63Postnatal microcephaly (HP:0005484)1.89973410
64Female pseudohermaphroditism (HP:0010458)1.89401936
65Bile duct proliferation (HP:0001408)1.89322319
66Abnormal biliary tract physiology (HP:0012439)1.89322319
67Meckel diverticulum (HP:0002245)1.88383352
68Delayed closure of the anterior fontanelle (HP:0001476)1.87282613
69Increased hepatocellular lipid droplets (HP:0006565)1.87130499
70Abnormality of chromosome stability (HP:0003220)1.87023968
71Progressive inability to walk (HP:0002505)1.86071766
72Abnormality of the heme biosynthetic pathway (HP:0010472)1.83721924
73Postaxial foot polydactyly (HP:0001830)1.82647943
74Abnormality of midbrain morphology (HP:0002418)1.80735504
75Molar tooth sign on MRI (HP:0002419)1.80735504
76Pancytopenia (HP:0001876)1.80454249
77Split foot (HP:0001839)1.80035336
78Abnormality of the ileum (HP:0001549)1.79127481
79Severe combined immunodeficiency (HP:0004430)1.78224957
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.77995507
81Glioma (HP:0009733)1.76811770
82Degeneration of anterior horn cells (HP:0002398)1.75354595
83Abnormality of the anterior horn cell (HP:0006802)1.75354595
84Increased intramyocellular lipid droplets (HP:0012240)1.74693884
85Primary adrenal insufficiency (HP:0008207)1.74170760
86Vaginal atresia (HP:0000148)1.73926160
87Abnormality of glycolysis (HP:0004366)1.73863614
88Erythroderma (HP:0001019)1.72668153
89Opisthotonus (HP:0002179)1.72122222
90Rough bone trabeculation (HP:0100670)1.71784110
91Genital tract atresia (HP:0001827)1.71563819
92Respiratory failure (HP:0002878)1.71264835
93Bone marrow hypocellularity (HP:0005528)1.70086171
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69769628
95Hypoplastic pelvis (HP:0008839)1.69657858
96Secondary amenorrhea (HP:0000869)1.69455527
97Exercise intolerance (HP:0003546)1.68592808
98Multicystic kidney dysplasia (HP:0000003)1.67659020
99Abnormality of the hip-girdle musculature (HP:0001445)1.67221916
100Abnormality of the musculature of the pelvis (HP:0001469)1.67221916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.20813523
2BCKDK3.20392422
3VRK23.03046332
4TRIM282.99116829
5PIM22.72954412
6CSNK1G32.69019090
7BUB12.56806509
8BCR2.55026408
9MAP4K22.54056032
10MAP2K72.53794981
11CSNK1A1L2.35830279
12ZAK2.29818351
13NME22.23156918
14CSNK1G12.21363482
15CSNK1G22.08507689
16SCYL22.06821673
17EIF2AK32.01062812
18TESK22.00045974
19CDK191.86636003
20NUAK11.77352415
21STK161.76208396
22VRK11.74602879
23CDC71.72247457
24DYRK31.69227859
25PBK1.67791505
26NEK11.66607175
27EIF2AK11.61166844
28MAP3K41.59141278
29PLK41.57694089
30RPS6KA41.54178609
31PASK1.47003841
32BRSK21.41339571
33KDR1.39574709
34CCNB11.38895599
35TESK11.36995040
36WEE11.35536960
37ERBB31.24703606
38PLK11.19022214
39MST41.15302133
40EPHA31.11995094
41ADRBK21.10170753
42FRK1.09535588
43RPS6KA51.06125232
44AURKA1.02870778
45LIMK11.01889575
46DYRK21.01369820
47ABL21.01042454
48ATR0.98770272
49CHEK20.90297373
50MAP3K120.87156301
51WNK30.81260313
52PDK20.81024081
53STK100.77365573
54MAPK130.75089500
55AURKB0.74135153
56TAF10.71502343
57TSSK60.70307999
58CDK90.70097189
59CDK60.67951768
60MKNK10.67038378
61FGR0.65695817
62CDK70.63952402
63MAP3K50.62777661
64PLK20.61535741
65PLK30.58726920
66CASK0.57316151
67ATM0.55567509
68CSNK2A10.54275101
69MAP3K140.53767611
70BRSK10.52571063
71PIK3CG0.49994431
72MKNK20.49799700
73TTK0.49018925
74CSNK1A10.42481778
75CDK40.41846056
76BMPR1B0.40436730
77CSNK2A20.39540368
78NME10.39378636
79CHEK10.39142610
80IKBKB0.35864358
81CDK80.35003716
82EPHB20.34035671
83PRKCE0.34009061
84BRD40.33841165
85TLK10.32312196
86RPS6KB20.30932878
87PAK40.30344902
88PKN10.29532398
89MAP2K40.28436916
90GRK70.27502629
91CDK140.27055264
92PIM10.25506663
93PINK10.25305283
94MATK0.25260804
95CAMKK20.25090231
96ADRBK10.24746784
97ITK0.24346199
98EIF2AK20.23927853
99MAPKAPK50.23315104
100CAMK2B0.23201806

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.00145474
2Non-homologous end-joining_Homo sapiens_hsa034503.06469000
3DNA replication_Homo sapiens_hsa030303.05835297
4Mismatch repair_Homo sapiens_hsa034302.97905026
5Fanconi anemia pathway_Homo sapiens_hsa034602.87768652
6Base excision repair_Homo sapiens_hsa034102.74942473
7Sulfur relay system_Homo sapiens_hsa041222.65009349
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52326163
9Spliceosome_Homo sapiens_hsa030402.44081570
10Homologous recombination_Homo sapiens_hsa034402.41145628
11RNA polymerase_Homo sapiens_hsa030202.38274935
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32280586
13Oxidative phosphorylation_Homo sapiens_hsa001902.28215076
14Pyrimidine metabolism_Homo sapiens_hsa002402.14397941
15Protein export_Homo sapiens_hsa030602.12990098
16RNA transport_Homo sapiens_hsa030132.07977879
17Nucleotide excision repair_Homo sapiens_hsa034202.06243605
18Parkinsons disease_Homo sapiens_hsa050122.03100271
19Ribosome_Homo sapiens_hsa030101.91403125
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82739407
21Huntingtons disease_Homo sapiens_hsa050161.62403999
22RNA degradation_Homo sapiens_hsa030181.57984327
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56283012
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46287578
25Cell cycle_Homo sapiens_hsa041101.44808270
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37816969
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35983923
28Basal transcription factors_Homo sapiens_hsa030221.35366462
29One carbon pool by folate_Homo sapiens_hsa006701.34162896
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31955592
31Purine metabolism_Homo sapiens_hsa002301.28911075
32p53 signaling pathway_Homo sapiens_hsa041151.28808067
33Peroxisome_Homo sapiens_hsa041461.28631931
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26273150
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24950032
36Selenocompound metabolism_Homo sapiens_hsa004501.23126143
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.22042059
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19967090
39Steroid biosynthesis_Homo sapiens_hsa001001.19377469
40Systemic lupus erythematosus_Homo sapiens_hsa053221.16617544
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14439770
42Alzheimers disease_Homo sapiens_hsa050101.13877010
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11093990
44mRNA surveillance pathway_Homo sapiens_hsa030151.10211247
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07211372
46Sulfur metabolism_Homo sapiens_hsa009201.05566479
47Regulation of autophagy_Homo sapiens_hsa041401.02217615
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01831229
49Folate biosynthesis_Homo sapiens_hsa007901.01196367
50Propanoate metabolism_Homo sapiens_hsa006400.99250961
51Fatty acid elongation_Homo sapiens_hsa000620.96438368
52N-Glycan biosynthesis_Homo sapiens_hsa005100.95834488
53Primary immunodeficiency_Homo sapiens_hsa053400.95350955
54Alcoholism_Homo sapiens_hsa050340.93927786
55Glutathione metabolism_Homo sapiens_hsa004800.93187553
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90918312
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89943953
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84694023
59Metabolic pathways_Homo sapiens_hsa011000.80344730
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79753783
61Biosynthesis of amino acids_Homo sapiens_hsa012300.79457121
62Butanoate metabolism_Homo sapiens_hsa006500.76592728
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.73353457
64Carbon metabolism_Homo sapiens_hsa012000.72288700
65Epstein-Barr virus infection_Homo sapiens_hsa051690.70980811
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66219586
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61896424
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55847777
69Herpes simplex infection_Homo sapiens_hsa051680.55525574
70Viral carcinogenesis_Homo sapiens_hsa052030.53010470
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50925213
72Collecting duct acid secretion_Homo sapiens_hsa049660.49791435
73Legionellosis_Homo sapiens_hsa051340.49040874
74Pyruvate metabolism_Homo sapiens_hsa006200.48630951
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48014335
76Shigellosis_Homo sapiens_hsa051310.46391786
77Vibrio cholerae infection_Homo sapiens_hsa051100.45196336
78Tyrosine metabolism_Homo sapiens_hsa003500.40133386
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36710041
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.35862903
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32413374
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31840974
83Salmonella infection_Homo sapiens_hsa051320.28360923
84Fatty acid metabolism_Homo sapiens_hsa012120.27798040
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27649155
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25362214
87Circadian rhythm_Homo sapiens_hsa047100.23334068
88Apoptosis_Homo sapiens_hsa042100.20724466
89Phototransduction_Homo sapiens_hsa047440.20389305
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18593551
91Ether lipid metabolism_Homo sapiens_hsa005650.17993831
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.17775960
93Hepatitis B_Homo sapiens_hsa051610.17278892
94Oocyte meiosis_Homo sapiens_hsa041140.14492847
95Vitamin B6 metabolism_Homo sapiens_hsa007500.13985775
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.12377526
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10819694
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09156880
99Rheumatoid arthritis_Homo sapiens_hsa053230.08681190
100Phenylalanine metabolism_Homo sapiens_hsa003600.07706497

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