TP53TG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.81663784
2sperm motility (GO:0030317)9.14213196
3chromosome organization involved in meiosis (GO:0070192)8.67732430
4piRNA metabolic process (GO:0034587)8.47464469
5binding of sperm to zona pellucida (GO:0007339)8.46047631
6spermatid development (GO:0007286)8.22708573
7synaptonemal complex assembly (GO:0007130)7.92243942
8fusion of sperm to egg plasma membrane (GO:0007342)7.75071674
9multicellular organism reproduction (GO:0032504)7.53324942
10sperm-egg recognition (GO:0035036)7.43086499
11synaptonemal complex organization (GO:0070193)7.15013681
12DNA methylation involved in gamete generation (GO:0043046)7.03737298
13male meiosis I (GO:0007141)7.03726258
14meiotic nuclear division (GO:0007126)6.78209384
15regulation of phosphoprotein phosphatase activity (GO:0043666)6.59049758
16cell-cell recognition (GO:0009988)6.13695277
17motile cilium assembly (GO:0044458)6.09700253
18DNA synthesis involved in DNA repair (GO:0000731)6.03502946
19reproduction (GO:0000003)5.96993538
20plasma membrane fusion (GO:0045026)5.92202403
21axonemal dynein complex assembly (GO:0070286)5.87374326
22meiosis I (GO:0007127)5.87296650
23polyamine biosynthetic process (GO:0006596)5.51218390
24positive regulation of catecholamine secretion (GO:0033605)5.40005194
25microtubule depolymerization (GO:0007019)5.22351022
26germ cell development (GO:0007281)5.20815600
27histone exchange (GO:0043486)5.14243917
28regulation of meiosis I (GO:0060631)5.13341024
29DNA packaging (GO:0006323)5.07226340
30calcium ion-dependent exocytosis (GO:0017156)5.03984131
31negative regulation of inclusion body assembly (GO:0090084)5.01231340
32spermatid nucleus differentiation (GO:0007289)4.98680540
33single fertilization (GO:0007338)4.97151648
34meiotic cell cycle process (GO:1903046)4.96001826
35chromosome condensation (GO:0030261)4.92346339
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.91726752
37cilium or flagellum-dependent cell motility (GO:0001539)4.88549687
38spermatogenesis (GO:0007283)4.82263980
39male gamete generation (GO:0048232)4.81361678
40nucleosome disassembly (GO:0006337)4.79470989
41protein-DNA complex disassembly (GO:0032986)4.79470989
42sperm capacitation (GO:0048240)4.78795927
43histone H3-K9 demethylation (GO:0033169)4.69327987
44fertilization (GO:0009566)4.65690737
45relaxation of smooth muscle (GO:0044557)4.58902009
46epithelial cilium movement (GO:0003351)4.57762255
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.55408674
48gamete generation (GO:0007276)4.54432431
49organic cation transport (GO:0015695)4.32972218
50acrosome assembly (GO:0001675)4.29325283
51potassium ion export (GO:0071435)4.22605147
52rRNA methylation (GO:0031167)4.16193276
53single strand break repair (GO:0000012)4.13285823
54regulation of oxidative phosphorylation (GO:0002082)4.11503082
55phosphatidylethanolamine biosynthetic process (GO:0006646)4.02892189
56oogenesis (GO:0048477)3.89340981
57microtubule polymerization or depolymerization (GO:0031109)3.85927922
58response to acidic pH (GO:0010447)3.83991742
59regulation of oxidative stress-induced neuron death (GO:1903203)3.81334772
60coenzyme catabolic process (GO:0009109)3.79820544
61cilium movement (GO:0003341)3.78333230
62cellular biogenic amine biosynthetic process (GO:0042401)3.75988763
63female gamete generation (GO:0007292)3.70658921
64centriole assembly (GO:0098534)3.67006934
65phosphatidylethanolamine metabolic process (GO:0046337)3.65481088
66membrane repolarization during action potential (GO:0086011)3.64812331
67amine biosynthetic process (GO:0009309)3.61682790
68multicellular organismal reproductive process (GO:0048609)3.61255777
69sister chromatid cohesion (GO:0007062)3.60677535
70resolution of meiotic recombination intermediates (GO:0000712)3.53981571
71regulation of cilium movement (GO:0003352)3.46006482
72rRNA modification (GO:0000154)3.37464423
73response to pheromone (GO:0019236)3.35618525
74regulation of histone H3-K9 methylation (GO:0051570)3.34400367
75meiotic cell cycle (GO:0051321)3.33280847
76male sex determination (GO:0030238)3.32433824
77gene silencing by RNA (GO:0031047)3.31124416
78regulation of inclusion body assembly (GO:0090083)3.27927053
79polyamine metabolic process (GO:0006595)3.21480088
80centriole replication (GO:0007099)3.20974532
81protein polymerization (GO:0051258)3.19347886
82mitochondrion degradation (GO:0000422)3.15682291
83activation of protein kinase B activity (GO:0032148)3.14071382
84ketone body metabolic process (GO:1902224)3.13260349
85cellular ketone body metabolic process (GO:0046950)3.12655373
86cellular response to pH (GO:0071467)3.09879342
87regulation of hydrogen peroxide-induced cell death (GO:1903205)3.06381966
88detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.06272548
89TOR signaling (GO:0031929)2.98167630
90meiotic chromosome segregation (GO:0045132)2.94758014
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92227199
92chromosome organization (GO:0051276)2.91443090
93ventricular system development (GO:0021591)2.88350403
94sex differentiation (GO:0007548)2.86262212
95regulation of cellular respiration (GO:0043457)2.85054412
96microtubule severing (GO:0051013)2.83650190
97gene silencing (GO:0016458)2.81180001
98membrane repolarization (GO:0086009)2.79931978
99male meiosis (GO:0007140)10.7828626
100synapsis (GO:0007129)10.5233569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.59254519
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.88462107
3EZH2_22144423_ChIP-Seq_EOC_Human3.96155895
4IGF1R_20145208_ChIP-Seq_DFB_Human3.43666715
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90299553
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.89240023
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.50578195
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41548980
9ERA_21632823_ChIP-Seq_H3396_Human2.32773267
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28399075
11NANOG_20526341_ChIP-Seq_ESCs_Human2.24977608
12ER_23166858_ChIP-Seq_MCF-7_Human2.24121853
13VDR_22108803_ChIP-Seq_LS180_Human2.20249830
14* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06108323
15RAC3_21632823_ChIP-Seq_H3396_Human2.02541825
16POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01286649
17TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01286649
18* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.91463131
19CBP_20019798_ChIP-Seq_JUKART_Human1.91048977
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91048977
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.90986967
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87349816
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.86351951
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77320317
25OCT4_20526341_ChIP-Seq_ESCs_Human1.74941684
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72708875
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.69947674
28MYC_19829295_ChIP-Seq_ESCs_Human1.68113288
29ERG_20517297_ChIP-Seq_VCAP_Human1.67765876
30SMC4_20622854_ChIP-Seq_HELA_Human1.66832838
31OCT1_27270436_Chip-Seq_PROSTATE_Human1.66405215
32* FUS_26573619_Chip-Seq_HEK293_Human1.65528732
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64875511
34* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64038941
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56738168
36CTCF_20526341_ChIP-Seq_ESCs_Human1.55041223
37PHF8_20622854_ChIP-Seq_HELA_Human1.53369646
38E2F1_17053090_ChIP-ChIP_MCF-7_Human1.52087355
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50395583
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.49795234
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.48678684
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48496306
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.47233115
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47188051
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.44667443
46P68_20966046_ChIP-Seq_HELA_Human1.43500869
47E2F1_20622854_ChIP-Seq_HELA_Human1.43408848
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.42163860
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41625469
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.40995127
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37843617
52P300_27268052_Chip-Seq_Bcells_Human1.36601719
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35869514
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35751851
55AR_25329375_ChIP-Seq_VCAP_Human1.35210869
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34449039
57* TBL1_22424771_ChIP-Seq_293T_Human1.33587600
58CTCF_27219007_Chip-Seq_Bcells_Human1.33308788
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32718221
60IRF1_19129219_ChIP-ChIP_H3396_Human1.31301658
61* HOXB7_26014856_ChIP-Seq_BT474_Human1.31141092
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30905796
63RUNX2_22187159_ChIP-Seq_PCA_Human1.30877568
64PHF8_20622853_ChIP-Seq_HELA_Human1.30651170
65BCL6_27268052_Chip-Seq_Bcells_Human1.30643053
66ZNF274_21170338_ChIP-Seq_K562_Hela1.30543036
67BCAT_22108803_ChIP-Seq_LS180_Human1.30424973
68RBPJ_21746931_ChIP-Seq_IB4_Human1.27677000
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27217107
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27152908
71NFYB_21822215_ChIP-Seq_K562_Human1.26259094
72AR_21909140_ChIP-Seq_LNCAP_Human1.25235876
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.24531438
74BCOR_27268052_Chip-Seq_Bcells_Human1.22490420
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22042804
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21546811
77NANOG_19829295_ChIP-Seq_ESCs_Human1.21075137
78SOX2_19829295_ChIP-Seq_ESCs_Human1.21075137
79AHR_22903824_ChIP-Seq_MCF-7_Human1.19644024
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16606727
81ETV1_20927104_ChIP-Seq_GIST48_Human1.15671738
82AR_21572438_ChIP-Seq_LNCaP_Human1.14026417
83CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11897176
84SPI1_20517297_ChIP-Seq_HL60_Human1.11617195
85GBX2_23144817_ChIP-Seq_PC3_Human1.11535191
86TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11016627
87GATA6_21074721_ChIP-Seq_CACO-2_Human1.09967661
88P300_19829295_ChIP-Seq_ESCs_Human1.08454573
89CTCF_21964334_Chip-Seq_Bcells_Human1.06639566
90NCOR_22424771_ChIP-Seq_293T_Human1.05334378
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04192577
92GATA3_26560356_Chip-Seq_TH1_Human1.03524257
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.02776080
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00772350
95TP63_22573176_ChIP-Seq_HFKS_Human1.00720701
96NFYA_21822215_ChIP-Seq_K562_Human1.00063985
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.99693218
98SMAD4_21799915_ChIP-Seq_A2780_Human0.99114567
99STAT1_20625510_ChIP-Seq_HELA_Human0.98276543
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96313511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.77828945
2MP0008004_abnormal_stomach_pH5.07199266
3MP0003698_abnormal_male_reproductive4.26327706
4MP0001929_abnormal_gametogenesis4.19194595
5MP0008877_abnormal_DNA_methylation3.83358376
6MP0003718_maternal_effect3.48942963
7MP0002160_abnormal_reproductive_system3.28918812
8MP0003315_abnormal_perineum_morphology3.22073578
9MP0002210_abnormal_sex_determination3.15744780
10MP0003136_yellow_coat_color2.73383912
11MP0002132_abnormal_respiratory_system2.52493857
12MP0002161_abnormal_fertility/fecundity2.46747200
13MP0001145_abnormal_male_reproductive2.46668804
14MP0008058_abnormal_DNA_repair2.35258338
15MP0000653_abnormal_sex_gland2.34563951
16MP0005360_urolithiasis2.28323746
17MP0000372_irregular_coat_pigmentation2.14301927
18MP0005058_abnormal_lysosome_morphology2.10542177
19MP0000678_abnormal_parathyroid_gland1.95599898
20MP0003646_muscle_fatigue1.86149966
21MP0005647_abnormal_sex_gland1.79546717
22MP0005389_reproductive_system_phenotype1.77570728
23MP0005394_taste/olfaction_phenotype1.64324244
24MP0005499_abnormal_olfactory_system1.64324244
25MP0005395_other_phenotype1.45206777
26MP0000015_abnormal_ear_pigmentation1.43242623
27MP0008995_early_reproductive_senescence1.42612661
28MP0003693_abnormal_embryo_hatching1.35611559
29MP0001984_abnormal_olfaction1.33367324
30MP0010368_abnormal_lymphatic_system1.31752960
31MP0005464_abnormal_platelet_physiology1.25475218
32MP0008789_abnormal_olfactory_epithelium1.24440156
33MP0005377_hearing/vestibular/ear_phenot1.22740308
34MP0003878_abnormal_ear_physiology1.22740308
35MP0009697_abnormal_copulation1.20564083
36MP0001664_abnormal_digestion1.17553640
37MP0010094_abnormal_chromosome_stability1.13763496
38MP0005670_abnormal_white_adipose1.13647442
39MP0003699_abnormal_female_reproductive1.13175079
40MP0006036_abnormal_mitochondrial_physio1.13162570
41MP0004036_abnormal_muscle_relaxation1.09029995
42MP0005174_abnormal_tail_pigmentation1.08924541
43MP0010386_abnormal_urinary_bladder1.03889553
44MP0001119_abnormal_female_reproductive1.02213019
45MP0003879_abnormal_hair_cell0.98758887
46MP0005408_hypopigmentation0.97784087
47MP0001968_abnormal_touch/_nociception0.96320937
48MP0004084_abnormal_cardiac_muscle0.93219469
49MP0005187_abnormal_penis_morphology0.92523726
50MP0002822_catalepsy0.92329629
51MP0001879_abnormal_lymphatic_vessel0.92130201
52MP0005646_abnormal_pituitary_gland0.91636351
53MP0003077_abnormal_cell_cycle0.91074987
54MP0002249_abnormal_larynx_morphology0.89090866
55MP0003936_abnormal_reproductive_system0.88423640
56MP0004381_abnormal_hair_follicle0.87131040
57MP0003806_abnormal_nucleotide_metabolis0.84589068
58MP0001905_abnormal_dopamine_level0.82022216
59MP0005253_abnormal_eye_physiology0.81072775
60MP0004085_abnormal_heartbeat0.80658870
61MP0005171_absent_coat_pigmentation0.79030676
62MP0004233_abnormal_muscle_weight0.77441009
63MP0001188_hyperpigmentation0.75989572
64MP0001919_abnormal_reproductive_system0.74881437
65MP0003045_fibrosis0.74166559
66MP0002282_abnormal_trachea_morphology0.72529489
67MP0002095_abnormal_skin_pigmentation0.71108923
68MP0001485_abnormal_pinna_reflex0.70429578
69MP0005551_abnormal_eye_electrophysiolog0.70422272
70MP0002090_abnormal_vision0.70352730
71MP0000537_abnormal_urethra_morphology0.69113669
72MP0005423_abnormal_somatic_nervous0.63665352
73MP0002736_abnormal_nociception_after0.63406812
74MP0005248_abnormal_Harderian_gland0.62437940
75MP0005409_darkened_coat_color0.61799234
76MP0002735_abnormal_chemical_nociception0.60317125
77MP0000230_abnormal_systemic_arterial0.60172473
78MP0001849_ear_inflammation0.58632078
79MP0002127_abnormal_cardiovascular_syste0.58369167
80MP0006035_abnormal_mitochondrial_morpho0.57403083
81MP0003111_abnormal_nucleus_morphology0.56662100
82MP0001765_abnormal_ion_homeostasis0.52559604
83MP0005075_abnormal_melanosome_morpholog0.52111848
84MP0000343_altered_response_to0.51560257
85MP0001986_abnormal_taste_sensitivity0.50933818
86MP0004957_abnormal_blastocyst_morpholog0.50025629
87MP0008932_abnormal_embryonic_tissue0.49664429
88MP0000631_abnormal_neuroendocrine_gland0.49631655
89MP0001963_abnormal_hearing_physiology0.49090585
90MP0000465_gastrointestinal_hemorrhage0.48635638
91MP0008775_abnormal_heart_ventricle0.47850199
92MP0001661_extended_life_span0.47252246
93MP0000026_abnormal_inner_ear0.46939041
94MP0005451_abnormal_body_composition0.46737366
95MP0000371_diluted_coat_color0.46678114
96MP0002638_abnormal_pupillary_reflex0.46672811
97MP0002229_neurodegeneration0.43029533
98MP0000681_abnormal_thyroid_gland0.41763129
99MP0001730_embryonic_growth_arrest0.41087925
100MP0002067_abnormal_sensory_capabilities0.40960996

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.70837426
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.70837426
3Resting tremor (HP:0002322)6.24735019
4Abnormal ciliary motility (HP:0012262)5.93864501
5Abnormal respiratory motile cilium physiology (HP:0012261)5.77736408
6Infertility (HP:0000789)5.38454644
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.16695100
8Hypoplasia of the uterus (HP:0000013)5.03864348
9Abnormal respiratory epithelium morphology (HP:0012253)4.93994383
10Abnormal respiratory motile cilium morphology (HP:0005938)4.93994383
11Azoospermia (HP:0000027)4.35517043
12Postural instability (HP:0002172)4.23879333
13Abnormal sex determination (HP:0012244)4.20574814
14Sex reversal (HP:0012245)4.20574814
15Male infertility (HP:0003251)3.97750178
16Severe visual impairment (HP:0001141)3.80449802
17Gonadal dysgenesis (HP:0000133)3.77452053
18Abnormal spermatogenesis (HP:0008669)3.72098973
19Ventricular fibrillation (HP:0001663)3.68468676
20Aplasia/hypoplasia of the uterus (HP:0008684)3.62783739
21Rhinitis (HP:0012384)3.50148234
22Reduced antithrombin III activity (HP:0001976)3.33505248
23Facial hemangioma (HP:0000329)3.23126071
24Male pseudohermaphroditism (HP:0000037)3.22798372
25Nasal polyposis (HP:0100582)3.08377234
26Congenital sensorineural hearing impairment (HP:0008527)3.03445085
27Abnormality of the columella (HP:0009929)3.01888128
28Abnormality of macular pigmentation (HP:0008002)2.83746451
29Tubulointerstitial nephritis (HP:0001970)2.78951683
30Self-mutilation (HP:0000742)2.76990980
31Bony spicule pigmentary retinopathy (HP:0007737)2.75880898
32Type II lissencephaly (HP:0007260)2.75693055
33Cerebellar dysplasia (HP:0007033)2.73971791
34Colitis (HP:0002583)2.61093885
35Attenuation of retinal blood vessels (HP:0007843)2.61013460
36Urinary urgency (HP:0000012)2.59921469
37Decreased central vision (HP:0007663)2.57989152
38Prolonged bleeding time (HP:0003010)2.56326161
39Osteomalacia (HP:0002749)2.52008018
40Retinal dysplasia (HP:0007973)2.51583907
41Absent thumb (HP:0009777)2.51202399
42Generalized aminoaciduria (HP:0002909)2.49769510
43Abnormality of the nasal mucosa (HP:0000433)2.40802898
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37619344
45Horizontal nystagmus (HP:0000666)2.36539172
46Menorrhagia (HP:0000132)2.34740409
47Abnormality of lateral ventricle (HP:0030047)2.34584719
48Hypophosphatemic rickets (HP:0004912)2.34321182
49Sensory axonal neuropathy (HP:0003390)2.33444198
50Ectopic kidney (HP:0000086)2.28607412
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.27843305
52Aplasia/Hypoplasia of the earlobes (HP:0009906)2.26736578
53Syncope (HP:0001279)2.23843816
54Chromsome breakage (HP:0040012)2.22985240
55Capillary hemangiomas (HP:0005306)2.22788516
56Abnormality of DNA repair (HP:0003254)2.22398213
57Germ cell neoplasia (HP:0100728)2.20804828
58Bronchiectasis (HP:0002110)2.19332808
59Spontaneous abortion (HP:0005268)2.18923311
60Abnormality of the ileum (HP:0001549)2.18213563
61Abnormal rod and cone electroretinograms (HP:0008323)2.17610621
62Small intestinal stenosis (HP:0012848)2.14500741
63Duodenal stenosis (HP:0100867)2.14500741
64Atonic seizures (HP:0010819)2.09851145
65Anterior segment dysgenesis (HP:0007700)2.09416337
66Impulsivity (HP:0100710)2.03831510
67Congenital stationary night blindness (HP:0007642)2.03436719
68Meckel diverticulum (HP:0002245)2.02332168
69Median cleft lip (HP:0000161)2.00852715
70Chronic bronchitis (HP:0004469)1.98634208
71Retinal atrophy (HP:0001105)1.96957675
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95500849
73Bradykinesia (HP:0002067)1.95065179
74Hyperthyroidism (HP:0000836)1.94565965
75Abnormality of the preputium (HP:0100587)1.91807142
76Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90601498
77Bell-shaped thorax (HP:0001591)1.87308183
78Dyschromatopsia (HP:0007641)1.86869631
79Aplasia/Hypoplasia of the macula (HP:0008059)1.86376449
80Upper limb muscle weakness (HP:0003484)1.84243864
81Gonadotropin excess (HP:0000837)1.79587014
82Petechiae (HP:0000967)1.75980208
83Optic nerve hypoplasia (HP:0000609)1.75609917
84Cutaneous melanoma (HP:0012056)1.74843450
85Inflammation of the large intestine (HP:0002037)1.74283510
86Abnormality of chromosome stability (HP:0003220)1.74032530
87Hypoplasia of the fovea (HP:0007750)1.73764542
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.73764542
89Occipital encephalocele (HP:0002085)1.73448344
90Abnormality of the intrinsic pathway (HP:0010989)1.72785048
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72313478
92Abnormal large intestine physiology (HP:0012700)1.71380217
93Renal dysplasia (HP:0000110)1.71360682
94Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67703459
95Thoracic kyphosis (HP:0002942)1.67687057
96Aplasia/Hypoplasia affecting the retina (HP:0008061)1.67549309
97Unsteady gait (HP:0002317)1.66231742
98Abnormal protein glycosylation (HP:0012346)1.65930016
99Abnormal glycosylation (HP:0012345)1.65930016
100Abnormal protein N-linked glycosylation (HP:0012347)1.65930016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK19.12825699
2MARK35.41180269
3ZAK3.58738660
4TLK13.22492964
5PLK43.22219133
6MYLK2.98640553
7STK382.28692432
8NEK22.22763072
9PNCK2.02821191
10RPS6KA52.00597243
11MST1R1.63503595
12PRKD31.60996940
13ARAF1.56576860
14STK38L1.51619925
15MAP3K91.48606466
16PTK2B1.47801550
17LATS11.45789918
18BMPR1B1.41468966
19AKT31.33294389
20PLK21.26037220
21CDK191.25052319
22LATS21.24655382
23FRK1.22158550
24MET1.18960507
25MAP3K131.17476533
26DDR21.16044881
27INSRR1.15346855
28KSR21.12026681
29TESK11.10975747
30MAP4K21.09390664
31CDK31.03897253
32BRAF0.99758130
33PDPK10.95792099
34PDK20.89881710
35WNK10.88966014
36MAP2K70.87560515
37PAK10.85198494
38ACVR1B0.82898212
39STK30.81773295
40CDK70.80132969
41CDK120.79337191
42MAPK150.77009370
43PDK10.74818952
44BMX0.74656980
45NTRK30.73546706
46DYRK30.72538112
47AURKA0.71461010
48VRK10.69225507
49RET0.68079119
50PLK10.66118415
51CAMK1G0.64239177
52NEK60.63243375
53CDK140.60473060
54GRK10.60200444
55FGR0.58940795
56WEE10.56750249
57PKN10.56561655
58TTK0.52502244
59ATM0.51910824
60SGK2230.51636763
61SGK4940.51636763
62PRKG10.50877505
63MAP3K20.48977530
64EIF2AK10.48753379
65ILK0.48569814
66OXSR10.47609220
67MAP3K10.47319132
68STK160.45106231
69MAPK130.43620541
70CHEK10.42439749
71CCNB10.38031141
72BRSK20.37815001
73ROCK10.37380395
74PAK20.36538769
75MAP3K30.36399646
76CDK80.35897900
77BRD40.35810964
78RAF10.35697373
79MAPKAPK30.35285102
80PRKCQ0.34650165
81MAP3K80.33373206
82PIK3CG0.31812109
83CDC42BPA0.31613306
84ATR0.31277685
85MTOR0.30476277
86RIPK40.30120208
87CSNK1A1L0.29986394
88CAMK10.29982975
89CDK10.29023988
90PRKG20.28763562
91AKT20.28603522
92BTK0.28409342
93MOS0.27468642
94RPS6KB10.26690730
95PBK0.25695873
96CSNK1G30.25536017
97EGFR0.25467707
98EIF2AK30.25228353
99MAPK10.25194412
100MELK0.25052684

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.07721459
2Gap junction_Homo sapiens_hsa045404.11992981
3Olfactory transduction_Homo sapiens_hsa047403.12270669
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84905215
5Basal transcription factors_Homo sapiens_hsa030222.83182076
6Systemic lupus erythematosus_Homo sapiens_hsa053222.38676553
7Nitrogen metabolism_Homo sapiens_hsa009102.31349569
8Oocyte meiosis_Homo sapiens_hsa041142.30438897
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.23740078
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10051338
11Fatty acid biosynthesis_Homo sapiens_hsa000612.09635417
12Alcoholism_Homo sapiens_hsa050342.07553026
13Propanoate metabolism_Homo sapiens_hsa006402.07167254
14Apoptosis_Homo sapiens_hsa042102.06424379
15Butanoate metabolism_Homo sapiens_hsa006502.02311685
16Hedgehog signaling pathway_Homo sapiens_hsa043401.99023543
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.93423920
18Phagosome_Homo sapiens_hsa041451.89497005
19Arginine biosynthesis_Homo sapiens_hsa002201.89448944
20Dorso-ventral axis formation_Homo sapiens_hsa043201.84222836
21Fanconi anemia pathway_Homo sapiens_hsa034601.81772082
22RNA transport_Homo sapiens_hsa030131.81534090
23Homologous recombination_Homo sapiens_hsa034401.67355888
24Mismatch repair_Homo sapiens_hsa034301.49306613
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.43191250
26Pyruvate metabolism_Homo sapiens_hsa006201.42686395
27mRNA surveillance pathway_Homo sapiens_hsa030151.33273960
28Nucleotide excision repair_Homo sapiens_hsa034201.32355244
29Cell cycle_Homo sapiens_hsa041101.28621282
30Glutathione metabolism_Homo sapiens_hsa004801.26037458
31DNA replication_Homo sapiens_hsa030301.23248944
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13803373
33Taste transduction_Homo sapiens_hsa047421.13351668
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.11435294
35Phenylalanine metabolism_Homo sapiens_hsa003601.09228647
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.06811519
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05514904
38Tyrosine metabolism_Homo sapiens_hsa003501.04334907
39Purine metabolism_Homo sapiens_hsa002300.99973501
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92264142
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.85804563
42Sulfur relay system_Homo sapiens_hsa041220.83808529
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82565467
44RNA degradation_Homo sapiens_hsa030180.82100360
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81490303
46Arginine and proline metabolism_Homo sapiens_hsa003300.78887178
47Regulation of autophagy_Homo sapiens_hsa041400.78245683
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74331181
49Base excision repair_Homo sapiens_hsa034100.73874039
50Chemical carcinogenesis_Homo sapiens_hsa052040.69077161
51Platelet activation_Homo sapiens_hsa046110.68707804
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67368081
53Pentose phosphate pathway_Homo sapiens_hsa000300.66619232
54beta-Alanine metabolism_Homo sapiens_hsa004100.64178630
55Viral carcinogenesis_Homo sapiens_hsa052030.62668618
56PPAR signaling pathway_Homo sapiens_hsa033200.61164173
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60381990
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60160157
59Pyrimidine metabolism_Homo sapiens_hsa002400.59868216
60Synaptic vesicle cycle_Homo sapiens_hsa047210.57084850
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56269636
62Calcium signaling pathway_Homo sapiens_hsa040200.56211301
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55899329
64Circadian rhythm_Homo sapiens_hsa047100.55629521
65Retinol metabolism_Homo sapiens_hsa008300.50098810
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49922749
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49670214
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47830741
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46688024
70Type II diabetes mellitus_Homo sapiens_hsa049300.44324171
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44203385
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43643636
73Glucagon signaling pathway_Homo sapiens_hsa049220.42476634
74RNA polymerase_Homo sapiens_hsa030200.40747603
75Metabolic pathways_Homo sapiens_hsa011000.40161609
76Endocytosis_Homo sapiens_hsa041440.39083154
77Non-homologous end-joining_Homo sapiens_hsa034500.36969856
78mTOR signaling pathway_Homo sapiens_hsa041500.35760685
79ECM-receptor interaction_Homo sapiens_hsa045120.35701246
80Fatty acid metabolism_Homo sapiens_hsa012120.34610109
81Huntingtons disease_Homo sapiens_hsa050160.33289479
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.32042163
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31861986
84Oxytocin signaling pathway_Homo sapiens_hsa049210.31618375
85Choline metabolism in cancer_Homo sapiens_hsa052310.27989835
86Fatty acid degradation_Homo sapiens_hsa000710.27263283
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27119224
88Glycerolipid metabolism_Homo sapiens_hsa005610.26375911
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.26303076
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.26179761
91Gastric acid secretion_Homo sapiens_hsa049710.26061766
92Selenocompound metabolism_Homo sapiens_hsa004500.25783974
93ABC transporters_Homo sapiens_hsa020100.25754400
94Inositol phosphate metabolism_Homo sapiens_hsa005620.25449362
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23956436
96Prostate cancer_Homo sapiens_hsa052150.22007069
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21808694
98Renin secretion_Homo sapiens_hsa049240.20362190
99Endometrial cancer_Homo sapiens_hsa052130.20024373
100TGF-beta signaling pathway_Homo sapiens_hsa043500.19899587

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