ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	meiotic nuclear division (GO:0007126)	9.08618425
2	DNA methylation involved in gamete generation (GO:0043046)	9.05728548
3	regulation of meiosis I (GO:0060631)	8.24855591
4	meiotic cell cycle process (GO:1903046)	7.66410522
5	sister chromatid cohesion (GO:0007062)	6.69347830
6	reciprocal meiotic recombination (GO:0007131)	5.81129977
7	reciprocal DNA recombination (GO:0035825)	5.81129977
8	resolution of meiotic recombination intermediates (GO:0000712)	5.60390224
9	meiotic chromosome segregation (GO:0045132)	5.51892402
10	gene silencing by RNA (GO:0031047)	5.12703646
11	female gamete generation (GO:0007292)	4.78227700
12	proteasome assembly (GO:0043248)	4.55108802
13	gonadal mesoderm development (GO:0007506)	4.55040085
14	meiotic cell cycle (GO:0051321)	4.54940219
15	positive regulation of meiosis (GO:0045836)	4.23126124
16	binding of sperm to zona pellucida (GO:0007339)	4.15456735
17	histone exchange (GO:0043486)	4.13106246
18	regulation of meiotic cell cycle (GO:0051445)	4.13093853
19	positive regulation of meiotic cell cycle (GO:0051446)	3.99685155
20	regulation of histone H3-K9 methylation (GO:0051570)	3.80100432
21	histone H3-K9 demethylation (GO:0033169)	3.72410953
22	fusion of sperm to egg plasma membrane (GO:0007342)	3.67722239
23	oogenesis (GO:0048477)	3.61482732
24	DNA biosynthetic process (GO:0071897)	3.59025424
25	protein neddylation (GO:0045116)	3.58753170
26	spermatid development (GO:0007286)	3.55942537
27	reproductive system development (GO:0061458)	3.54939117
28	sperm-egg recognition (GO:0035036)	3.49508990
29	chromosome organization (GO:0051276)	3.45460005
30	DNA methylation (GO:0006306)	3.28024231
31	DNA alkylation (GO:0006305)	3.28024231
32	fertilization (GO:0009566)	3.26715558
33	acrosome assembly (GO:0001675)	3.25622532
34	sperm motility (GO:0030317)	3.23329509
35	mitotic sister chromatid cohesion (GO:0007064)	3.21317022
36	gene silencing (GO:0016458)	3.19224576
37	positive regulation of response to oxidative stress (GO:1902884)	3.18393356
38	positive regulation of cellular response to oxidative stress (GO:1900409)	3.18393356
39	regulation of meiosis (GO:0040020)	3.15769245
40	regulation of DNA endoreduplication (GO:0032875)	3.15274712
41	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.10382467
42	acrosome reaction (GO:0007340)	3.07464388
43	melanin biosynthetic process (GO:0042438)	3.04986434
44	male gamete generation (GO:0048232)	3.02831124
45	spermatogenesis (GO:0007283)	3.02492543
46	gamete generation (GO:0007276)	2.96910269
47	histone H2A acetylation (GO:0043968)	2.95634649
48	nuclear division (GO:0000280)	2.94516096
49	negative regulation of meiosis (GO:0045835)	2.94097190
50	CENP-A containing nucleosome assembly (GO:0034080)	2.94026819
51	germ cell development (GO:0007281)	2.92235040
52	DNA packaging (GO:0006323)	2.87443261
53	DNA replication checkpoint (GO:0000076)	2.86413436
54	mitotic chromosome condensation (GO:0007076)	2.85413957
55	plasma membrane fusion (GO:0045026)	2.85103742
56	protein localization to chromosome (GO:0034502)	2.82172659
57	attachment of spindle microtubules to kinetochore (GO:0008608)	2.79061104
58	organelle fission (GO:0048285)	2.78407215
59	DNA catabolic process, exonucleolytic (GO:0000738)	2.75610779
60	chromatin remodeling at centromere (GO:0031055)	2.74645181
61	negative regulation of inclusion body assembly (GO:0090084)	2.71214265
62	microtubule depolymerization (GO:0007019)	2.66693949
63	cell-cell recognition (GO:0009988)	2.66061603
64	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.61751315
65	melanin metabolic process (GO:0006582)	2.60423285
66	positive regulation of receptor recycling (GO:0001921)	2.52335289
67	DNA replication-dependent nucleosome assembly (GO:0006335)	2.47750464
68	DNA replication-dependent nucleosome organization (GO:0034723)	2.47750464
69	polyamine biosynthetic process (GO:0006596)	2.47160661
70	secondary metabolite biosynthetic process (GO:0044550)	2.43737651
71	negative regulation of gene silencing (GO:0060969)	2.42740967
72	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.42393655
73	regulation of cilium movement (GO:0003352)	2.42369089
74	centriole replication (GO:0007099)	2.41522980
75	regulation of centriole replication (GO:0046599)	2.40429828
76	mitotic metaphase plate congression (GO:0007080)	2.37565586
77	negative regulation of response to food (GO:0032096)	2.36624217
78	negative regulation of appetite (GO:0032099)	2.36624217
79	DNA methylation or demethylation (GO:0044728)	2.36518576
80	DNA replication-independent nucleosome organization (GO:0034724)	2.35472800
81	DNA replication-independent nucleosome assembly (GO:0006336)	2.35472800
82	genitalia morphogenesis (GO:0035112)	2.33298079
83	chromosome segregation (GO:0007059)	2.30523331
84	chaperone-mediated protein complex assembly (GO:0051131)	2.29885023
85	mitotic spindle assembly checkpoint (GO:0007094)	2.29659090
86	multicellular organismal reproductive process (GO:0048609)	2.29375430
87	protein refolding (GO:0042026)	2.27782279
88	regulation of microtubule-based movement (GO:0060632)	2.27211237
89	regulation of chromosome segregation (GO:0051983)	2.27197342
90	histone H3-K36 demethylation (GO:0070544)	2.26656360
91	centriole assembly (GO:0098534)	2.26527161
92	synapsis (GO:0007129)	14.9396013
93	chromosome organization involved in meiosis (GO:0070192)	13.4982377
94	synaptonemal complex assembly (GO:0007130)	13.3790072
95	piRNA metabolic process (GO:0034587)	12.7944109
96	male meiosis I (GO:0007141)	12.2448740
97	synaptonemal complex organization (GO:0070193)	12.1538122
98	DNA synthesis involved in DNA repair (GO:0000731)	11.2613153
99	male meiosis (GO:0007140)	10.6338332
100	meiosis I (GO:0007127)	10.3670873

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	6.84821624
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.37735085
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.27372502
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.85071586
5	E2F7_22180533_ChIP-Seq_HELA_Human	2.73759999
6	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.49398775
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.49006204
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34581985
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33491286
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31034320
11	DCP1A_22483619_ChIP-Seq_HELA_Human	2.21454894
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19136668
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.18576722
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.13935930
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02432915
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.99963392
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.96601530
18	RNF2_27304074_Chip-Seq_NSC_Mouse	1.92236379
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79008433
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73572932
21	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.71996117
22	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.69707663
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.68869343
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.66914856
25	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.65390903
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.65056183
27	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.64656065
28	VDR_22108803_ChIP-Seq_LS180_Human	1.62133725
29	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50288191
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.49442444
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48140945
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.47976730
33	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.47241068
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44550126
35	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.41744473
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.38689301
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.35910983
38	TFEB_21752829_ChIP-Seq_HELA_Human	1.33305017
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32705342
40	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.32269265
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.31947194
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.31627282
43	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29505923
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24414505
45	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.23360068
46	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.23360068
47	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.23360068
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21706139
49	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.20328019
50	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19848761
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19241329
52	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.19056714
53	FUS_26573619_Chip-Seq_HEK293_Human	1.15574113
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15497567
55	* ERA_21632823_ChIP-Seq_H3396_Human	1.14342333
56	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.14097553
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.13974758
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.11831982
59	PHF8_20622853_ChIP-Seq_HELA_Human	1.11067145
60	EWS_26573619_Chip-Seq_HEK293_Human	1.10552911
61	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.09966864
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09785367
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08649931
64	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08426898
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.08326190
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.05766522
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.05688481
68	GATA3_26560356_Chip-Seq_TH1_Human	1.04577643
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.04350236
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04264876
71	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.00417585
72	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99794600
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99338048
74	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.99120731
75	TAF15_26573619_Chip-Seq_HEK293_Human	0.97801140
76	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.95344397
77	ERG_20517297_ChIP-Seq_VCAP_Human	0.94703441
78	ZNF274_21170338_ChIP-Seq_K562_Hela	0.94333776
79	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94245082
80	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.94035126
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93961463
82	AR_20517297_ChIP-Seq_VCAP_Human	0.92872604
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92865787
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92865787
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91860214
86	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.90711695
87	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90127335
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89760060
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.89375539
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87670946
91	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.87649031
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.87347006
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.86994335
94	TP53_22573176_ChIP-Seq_HFKS_Human	0.86682046
95	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.86350348
96	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.86047615
97	SOX2_21211035_ChIP-Seq_LN229_Human	0.85879124
98	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.85045886
99	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.84337648
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.83986531

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	6.89386073
2	MP0008004_abnormal_stomach_pH	5.04258518
3	MP0008058_abnormal_DNA_repair	4.98436477
4	MP0000372_irregular_coat_pigmentation	4.87625147
5	MP0002210_abnormal_sex_determination	4.28443272
6	MP0001929_abnormal_gametogenesis	3.93906266
7	MP0005410_abnormal_fertilization	3.53969952
8	MP0003698_abnormal_male_reproductive	3.43901874
9	MP0003136_yellow_coat_color	3.39863702
10	MP0003718_maternal_effect	3.29365911
11	MP0002160_abnormal_reproductive_system	3.15183009
12	MP0001145_abnormal_male_reproductive	3.15023997
13	MP0005464_abnormal_platelet_physiology	3.13138176
14	MP0000653_abnormal_sex_gland	3.00120839
15	MP0010094_abnormal_chromosome_stability	2.41110506
16	MP0002161_abnormal_fertility/fecundity	2.06751863
17	MP0001119_abnormal_female_reproductive	1.98446243
18	MP0005389_reproductive_system_phenotype	1.97574377
19	MP0000015_abnormal_ear_pigmentation	1.94370421
20	MP0005075_abnormal_melanosome_morpholog	1.92753343
21	MP0005058_abnormal_lysosome_morphology	1.90670558
22	MP0003693_abnormal_embryo_hatching	1.81590052
23	MP0003699_abnormal_female_reproductive	1.80135474
24	MP0003111_abnormal_nucleus_morphology	1.77191625
25	MP0005171_absent_coat_pigmentation	1.72609276
26	MP0005174_abnormal_tail_pigmentation	1.72090369
27	MP0002095_abnormal_skin_pigmentation	1.60944938
28	MP0000678_abnormal_parathyroid_gland	1.59748452
29	MP0003646_muscle_fatigue	1.54207926
30	MP0008789_abnormal_olfactory_epithelium	1.53798650
31	MP0008932_abnormal_embryonic_tissue	1.53463034
32	MP0003077_abnormal_cell_cycle	1.45087933
33	MP0005408_hypopigmentation	1.41099478
34	MP0002877_abnormal_melanocyte_morpholog	1.39669771
35	MP0010368_abnormal_lymphatic_system	1.37611630
36	MP0004381_abnormal_hair_follicle	1.32256050
37	MP0004957_abnormal_blastocyst_morpholog	1.28941246
38	MP0005499_abnormal_olfactory_system	1.28426371
39	MP0005394_taste/olfaction_phenotype	1.28426371
40	MP0006036_abnormal_mitochondrial_physio	1.28147422
41	MP0000358_abnormal_cell_content/	1.23456922
42	MP0002132_abnormal_respiratory_system	1.16336688
43	MP0004147_increased_porphyrin_level	1.07602756
44	MP0003186_abnormal_redox_activity	1.07220079
45	MP0006035_abnormal_mitochondrial_morpho	1.06947342
46	MP0001730_embryonic_growth_arrest	1.05919684
47	MP0008007_abnormal_cellular_replicative	1.03913145
48	MP0008995_early_reproductive_senescence	1.02352740
49	MP0005395_other_phenotype	0.97766327
50	MP0002638_abnormal_pupillary_reflex	0.93018165
51	MP0010234_abnormal_vibrissa_follicle	0.92289413
52	MP0001984_abnormal_olfaction	0.90912140
53	MP0008260_abnormal_autophagy	0.88158543
54	MP0001188_hyperpigmentation	0.84992072
55	MP0005647_abnormal_sex_gland	0.84643434
56	MP0001879_abnormal_lymphatic_vessel	0.84430921
57	MP0004036_abnormal_muscle_relaxation	0.83727423
58	MP0002653_abnormal_ependyma_morphology	0.82297092
59	MP0005646_abnormal_pituitary_gland	0.82181340
60	MP0003786_premature_aging	0.81185079
61	MP0001661_extended_life_span	0.80855676
62	MP0005187_abnormal_penis_morphology	0.80696504
63	MP0010030_abnormal_orbit_morphology	0.72948765
64	MP0002090_abnormal_vision	0.70185001
65	MP0001664_abnormal_digestion	0.68317541
66	MP0004215_abnormal_myocardial_fiber	0.65736686
67	MP0002736_abnormal_nociception_after	0.64784422
68	MP0010307_abnormal_tumor_latency	0.64150379
69	MP0001697_abnormal_embryo_size	0.63900201
70	MP0002139_abnormal_hepatobiliary_system	0.63416283
71	MP0001986_abnormal_taste_sensitivity	0.61780014
72	MP0000313_abnormal_cell_death	0.61027223
73	MP0000350_abnormal_cell_proliferation	0.60543335
74	MP0001324_abnormal_eye_pigmentation	0.59633700
75	MP0003806_abnormal_nucleotide_metabolis	0.59524522
76	MP0003879_abnormal_hair_cell	0.57917492
77	MP0005084_abnormal_gallbladder_morpholo	0.55785028
78	MP0004019_abnormal_vitamin_homeostasis	0.55467628
79	MP0001919_abnormal_reproductive_system	0.52998113
80	MP0005551_abnormal_eye_electrophysiolog	0.52687348
81	MP0005501_abnormal_skin_physiology	0.50910556
82	MP0000371_diluted_coat_color	0.50842376
83	MP0005380_embryogenesis_phenotype	0.50790051
84	MP0001672_abnormal_embryogenesis/_devel	0.50790051
85	MP0004885_abnormal_endolymph	0.48341775
86	MP0002075_abnormal_coat/hair_pigmentati	0.48055895
87	MP0003638_abnormal_response/metabolism_	0.46446943
88	MP0008057_abnormal_DNA_replication	0.45737488
89	MP0002080_prenatal_lethality	0.45460866
90	MP0002084_abnormal_developmental_patter	0.44429434
91	MP0005423_abnormal_somatic_nervous	0.43552243
92	MP0000230_abnormal_systemic_arterial	0.42894892
93	MP0004233_abnormal_muscle_weight	0.41569351
94	MP0002822_catalepsy	0.41172510
95	MP0006292_abnormal_olfactory_placode	0.40631627
96	MP0001915_intracranial_hemorrhage	0.40477930
97	MP0004142_abnormal_muscle_tone	0.39916023
98	MP0002938_white_spotting	0.39862854
99	MP0001485_abnormal_pinna_reflex	0.38267596
100	MP0005384_cellular_phenotype	0.37938493

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Spontaneous abortion (HP:0005268)	6.11634094
2	Azoospermia (HP:0000027)	5.82558359
3	Abnormal spermatogenesis (HP:0008669)	4.93743396
4	Gonadotropin excess (HP:0000837)	4.26601405
5	Petechiae (HP:0000967)	3.97018102
6	Male infertility (HP:0003251)	3.91546052
7	Prolonged bleeding time (HP:0003010)	3.77336449
8	Horizontal nystagmus (HP:0000666)	3.59102784
9	Tubulointerstitial nephritis (HP:0001970)	3.56076262
10	Decreased central vision (HP:0007663)	3.52599231
11	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.52580104
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.52580104
13	Upper limb muscle weakness (HP:0003484)	3.46779196
14	Volvulus (HP:0002580)	3.45753372
15	Menorrhagia (HP:0000132)	3.31090442
16	Abnormal ciliary motility (HP:0012262)	3.04874539
17	Dyschromatopsia (HP:0007641)	3.03207090
18	Infertility (HP:0000789)	3.03190123
19	Absent/shortened dynein arms (HP:0200106)	2.90101842
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.90101842
21	Chromsome breakage (HP:0040012)	2.88849128
22	Ventricular fibrillation (HP:0001663)	2.88485656
23	Abnormal respiratory motile cilium physiology (HP:0012261)	2.86821125
24	Increased mean platelet volume (HP:0011877)	2.86490993
25	Generalized aminoaciduria (HP:0002909)	2.86015513
26	Purpura (HP:0000979)	2.81263286
27	White forelock (HP:0002211)	2.79915587
28	Oligodactyly (hands) (HP:0001180)	2.72262423
29	Abnormality of the corticospinal tract (HP:0002492)	2.70821172
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68361752
31	Abnormality of alanine metabolism (HP:0010916)	2.68361752
32	Hyperalaninemia (HP:0003348)	2.68361752
33	Patchy hypopigmentation of hair (HP:0011365)	2.68186445
34	Acanthocytosis (HP:0001927)	2.66982033
35	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.61811477
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.60997973
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.60997973
38	Cutaneous melanoma (HP:0012056)	2.60254831
39	Ectopic kidney (HP:0000086)	2.57056136
40	Hyperlipoproteinemia (HP:0010980)	2.56824961
41	Scotoma (HP:0000575)	2.56679618
42	Hypophosphatemic rickets (HP:0004912)	2.55117185
43	Osteomalacia (HP:0002749)	2.49006870
44	Abnormality of DNA repair (HP:0003254)	2.47824502
45	Abnormal platelet volume (HP:0011876)	2.47482048
46	Papillary thyroid carcinoma (HP:0002895)	2.47105494
47	Degeneration of anterior horn cells (HP:0002398)	2.46570917
48	Abnormality of the anterior horn cell (HP:0006802)	2.46570917
49	Increased nuchal translucency (HP:0010880)	2.43815555
50	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40587954
51	Abnormal auditory evoked potentials (HP:0006958)	2.40204291
52	Shoulder girdle muscle weakness (HP:0003547)	2.38409083
53	Aplasia/Hypoplasia of the macula (HP:0008059)	2.35413328
54	Abnormality of the fovea (HP:0000493)	2.34033707
55	Abnormality of lateral ventricle (HP:0030047)	2.31001466
56	Congenital stationary night blindness (HP:0007642)	2.27409812
57	Abnormal lung lobation (HP:0002101)	2.27222494
58	Broad distal phalanx of finger (HP:0009836)	2.26717970
59	Supernumerary spleens (HP:0009799)	2.24327295
60	Hypoplasia of the fovea (HP:0007750)	2.23242737
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.23242737
62	Impaired vibration sensation in the lower limbs (HP:0002166)	2.22261505
63	Wrist flexion contracture (HP:0001239)	2.21635443
64	Facial hemangioma (HP:0000329)	2.19993222
65	Poikilocytosis (HP:0004447)	2.19457338
66	Duodenal stenosis (HP:0100867)	2.16972718
67	Small intestinal stenosis (HP:0012848)	2.16972718
68	Rhinitis (HP:0012384)	2.16401345
69	Central scotoma (HP:0000603)	2.15001608
70	Capillary hemangiomas (HP:0005306)	2.14894407
71	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.13450725
72	Congenital sensorineural hearing impairment (HP:0008527)	2.11690727
73	Ocular albinism (HP:0001107)	2.10230601
74	Rimmed vacuoles (HP:0003805)	2.09476403
75	Epistaxis (HP:0000421)	2.08905808
76	Renal Fanconi syndrome (HP:0001994)	2.05519325
77	Paralysis (HP:0003470)	1.94735199
78	Conjunctival telangiectasia (HP:0000524)	1.93551487
79	Blue irides (HP:0000635)	1.92344514
80	Microglossia (HP:0000171)	1.91922619
81	Oligodactyly (HP:0012165)	1.90133637
82	Abnormal platelet function (HP:0011869)	1.87977188
83	Impaired platelet aggregation (HP:0003540)	1.87977188
84	Rickets (HP:0002748)	1.83744376
85	Iris hypopigmentation (HP:0007730)	1.81770987
86	Medial flaring of the eyebrow (HP:0010747)	1.80444857
87	Hypoplastic iliac wings (HP:0002866)	1.79999982
88	Lip pit (HP:0100267)	1.77840434
89	Absent thumb (HP:0009777)	1.76970299
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.76093923
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.76093923
92	Abnormal protein glycosylation (HP:0012346)	1.76093923
93	Abnormal glycosylation (HP:0012345)	1.76093923
94	Bell-shaped thorax (HP:0001591)	1.74875566
95	Thyroid carcinoma (HP:0002890)	1.74688729
96	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.74589795
97	Respiratory difficulties (HP:0002880)	1.73770743
98	Hyperthyroidism (HP:0000836)	1.73503008
99	Hand muscle atrophy (HP:0009130)	1.72459254
100	Prolonged neonatal jaundice (HP:0006579)	1.71405914

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.45474876
2	PNCK	4.87749223
3	CDK19	3.55465672
4	ACVR1B	3.28264995
5	MST4	3.24179677
6	STK16	2.42509541
7	EIF2AK1	2.32158768
8	MARK3	2.22940202
9	NEK9	2.21120504
10	ARAF	2.18593971
11	PLK4	2.17068735
12	TTK	2.09755419
13	MAP3K13	1.97463929
14	PTK2B	1.93803656
15	WEE1	1.85288185
16	BMX	1.75985756
17	MYLK	1.74556348
18	ZAK	1.71928199
19	BMPR2	1.70500425
20	PLK2	1.68035967
21	MET	1.64391916
22	MAPKAPK3	1.62238620
23	BRAF	1.56574686
24	WNK4	1.55110977
25	PLK1	1.45459940
26	MATK	1.42754144
27	MAP3K9	1.40529102
28	BMPR1B	1.34343187
29	PRKCI	1.22197865
30	KSR2	1.17128502
31	PINK1	1.16660104
32	OXSR1	1.09790357
33	VRK1	1.09239699
34	AURKA	1.07628497
35	STK3	1.06861377
36	KSR1	1.05529694
37	FER	1.03889529
38	AKT3	1.01080201
39	MAP3K3	1.00498712
40	WNK3	0.93999703
41	PAK1	0.93914252
42	STK38L	0.93373316
43	TLK1	0.93331792
44	FRK	0.93187082
45	RIPK4	0.92760029
46	STK38	0.89034148
47	STK39	0.86654961
48	RAF1	0.80986265
49	NEK6	0.79463242
50	ATR	0.78390284
51	PLK3	0.76562750
52	WNK1	0.76035164
53	MAP3K2	0.75722040
54	PBK	0.75118964
55	CDK7	0.72717650
56	CHEK1	0.72686065
57	ATM	0.71281260
58	TAOK3	0.68427395
59	TESK1	0.67036861
60	TESK2	0.64672633
61	NEK2	0.64384813
62	RET	0.63291290
63	EIF2AK3	0.62973942
64	BUB1	0.62236031
65	ILK	0.60667698
66	NUAK1	0.60513546
67	CDK8	0.59299410
68	BRSK1	0.59026565
69	CDK3	0.57205829
70	FGR	0.55164177
71	PDPK1	0.54539766
72	MAP3K5	0.52563373
73	BRSK2	0.50831411
74	CSF1R	0.49030933
75	PDK1	0.48397182
76	AKT2	0.43354868
77	CHEK2	0.42609443
78	PRKD1	0.42579042
79	LIMK1	0.41337673
80	BTK	0.39266593
81	TEC	0.38566375
82	MAPK13	0.38262733
83	CCNB1	0.37858042
84	CDK9	0.37789590
85	PIM1	0.37698490
86	MAP3K1	0.33871547
87	LMTK2	0.33750559
88	CAMK1G	0.32655158
89	MOS	0.32433065
90	RPS6KB1	0.31603161
91	NEK1	0.31435977
92	CDC7	0.29532916
93	CDK1	0.27842350
94	CSNK2A1	0.27320249
95	EGFR	0.26736256
96	CDK2	0.26656367
97	CDK14	0.26630729
98	MAP2K1	0.26290991
99	RPS6KB2	0.26268571
100	TRIM28	0.26216162

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.97788952
2	Mismatch repair_Homo sapiens_hsa03430	3.94414855
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.37263125
4	Basal transcription factors_Homo sapiens_hsa03022	3.16176073
5	DNA replication_Homo sapiens_hsa03030	2.99224491
6	Sulfur relay system_Homo sapiens_hsa04122	2.95476442
7	Cell cycle_Homo sapiens_hsa04110	2.88825317
8	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.85280495
9	Oocyte meiosis_Homo sapiens_hsa04114	2.70983624
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.69555014
11	RNA transport_Homo sapiens_hsa03013	2.47706316
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43761289
13	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.32044330
14	Base excision repair_Homo sapiens_hsa03410	2.23240993
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.13763862
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04782167
17	Fatty acid elongation_Homo sapiens_hsa00062	1.93878912
18	Proteasome_Homo sapiens_hsa03050	1.83074632
19	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.80352567
20	Propanoate metabolism_Homo sapiens_hsa00640	1.66630547
21	Regulation of autophagy_Homo sapiens_hsa04140	1.66372290
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.62971588
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.47833354
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46690059
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.45850508
26	Parkinsons disease_Homo sapiens_hsa05012	1.45612697
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.38471132
28	Huntingtons disease_Homo sapiens_hsa05016	1.35548482
29	Platelet activation_Homo sapiens_hsa04611	1.27606560
30	RNA degradation_Homo sapiens_hsa03018	1.26377305
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.25163387
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.20595934
33	p53 signaling pathway_Homo sapiens_hsa04115	1.17717480
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17248962
35	Purine metabolism_Homo sapiens_hsa00230	1.15378162
36	RNA polymerase_Homo sapiens_hsa03020	1.08647843
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.05271102
38	Folate biosynthesis_Homo sapiens_hsa00790	1.01022631
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93158522
40	Steroid biosynthesis_Homo sapiens_hsa00100	0.84686685
41	Gap junction_Homo sapiens_hsa04540	0.81060622
42	Olfactory transduction_Homo sapiens_hsa04740	0.79281913
43	Circadian rhythm_Homo sapiens_hsa04710	0.77443516
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77139956
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.75267891
46	Butanoate metabolism_Homo sapiens_hsa00650	0.75045616
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74934363
48	ABC transporters_Homo sapiens_hsa02010	0.74347213
49	One carbon pool by folate_Homo sapiens_hsa00670	0.72917674
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71988397
51	Thyroid cancer_Homo sapiens_hsa05216	0.66464227
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.66396899
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.65677197
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62732004
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61481252
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60361672
57	Pentose phosphate pathway_Homo sapiens_hsa00030	0.59892305
58	Sulfur metabolism_Homo sapiens_hsa00920	0.59095613
59	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53306900
60	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.53123827
61	Spliceosome_Homo sapiens_hsa03040	0.52705231
62	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.52335348
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51652332
64	Endocytosis_Homo sapiens_hsa04144	0.50496236
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49316458
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.48539711
67	Metabolic pathways_Homo sapiens_hsa01100	0.48486008
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48019603
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46775667
70	Glutathione metabolism_Homo sapiens_hsa00480	0.46686632
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44787056
72	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.42920869
73	Shigellosis_Homo sapiens_hsa05131	0.40745113
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.40236400
75	Protein export_Homo sapiens_hsa03060	0.40059728
76	Apoptosis_Homo sapiens_hsa04210	0.38436516
77	Small cell lung cancer_Homo sapiens_hsa05222	0.38056586
78	Alcoholism_Homo sapiens_hsa05034	0.37670753
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36426016
80	Caffeine metabolism_Homo sapiens_hsa00232	0.35916146
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.34863985
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.33036239
83	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32011297
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31606952
85	Phagosome_Homo sapiens_hsa04145	0.29751409
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29307360
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29244327
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25076160
89	mTOR signaling pathway_Homo sapiens_hsa04150	0.24505131
90	Serotonergic synapse_Homo sapiens_hsa04726	0.23686189
91	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23072243
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.20288366
93	Viral carcinogenesis_Homo sapiens_hsa05203	0.20151341
94	Lysosome_Homo sapiens_hsa04142	0.19892369
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.19784861
96	Retinol metabolism_Homo sapiens_hsa00830	0.19750064
97	ECM-receptor interaction_Homo sapiens_hsa04512	0.19565575
98	Phototransduction_Homo sapiens_hsa04744	0.17516662
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.16647540
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.15234818

TP53TG3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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