ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.22986085
2	synapsis (GO:0007129)	8.15190030
3	piRNA metabolic process (GO:0034587)	8.09649858
4	acrosome reaction (GO:0007340)	7.91547448
5	sperm motility (GO:0030317)	7.76466767
6	binding of sperm to zona pellucida (GO:0007339)	7.38564854
7	multicellular organism reproduction (GO:0032504)	7.03391721
8	fusion of sperm to egg plasma membrane (GO:0007342)	7.02286921
9	DNA methylation involved in gamete generation (GO:0043046)	6.81485279
10	spermatid development (GO:0007286)	6.59808593
11	sperm-egg recognition (GO:0035036)	6.47538506
12	chromosome organization involved in meiosis (GO:0070192)	6.29999374
13	synaptonemal complex assembly (GO:0007130)	5.68972877
14	male meiosis I (GO:0007141)	5.56985628
15	polyamine biosynthetic process (GO:0006596)	5.55872304
16	reproduction (GO:0000003)	5.54942152
17	meiotic nuclear division (GO:0007126)	5.52304590
18	plasma membrane fusion (GO:0045026)	5.30920570
19	meiosis I (GO:0007127)	5.26917249
20	cell-cell recognition (GO:0009988)	5.22506630
21	synaptonemal complex organization (GO:0070193)	5.20077517
22	regulation of oxidative phosphorylation (GO:0002082)	5.15819043
23	regulation of phosphoprotein phosphatase activity (GO:0043666)	5.10239289
24	relaxation of smooth muscle (GO:0044557)	5.09239508
25	regulation of meiosis I (GO:0060631)	4.94827063
26	spermatid nucleus differentiation (GO:0007289)	4.93299888
27	motile cilium assembly (GO:0044458)	4.92085865
28	single fertilization (GO:0007338)	4.63868582
29	rRNA methylation (GO:0031167)	4.44944680
30	axonemal dynein complex assembly (GO:0070286)	4.43142796
31	histone exchange (GO:0043486)	4.39691650
32	germ cell development (GO:0007281)	4.34868593
33	fertilization (GO:0009566)	4.27835983
34	regulation of histone H3-K9 methylation (GO:0051570)	4.19638796
35	calcium ion-dependent exocytosis (GO:0017156)	4.17861651
36	sperm capacitation (GO:0048240)	4.17454828
37	microtubule depolymerization (GO:0007019)	4.17372280
38	spermatogenesis (GO:0007283)	4.15570716
39	potassium ion export (GO:0071435)	4.15420808
40	male gamete generation (GO:0048232)	4.14374179
41	DNA packaging (GO:0006323)	4.12750520
42	DNA synthesis involved in DNA repair (GO:0000731)	4.12638047
43	rRNA modification (GO:0000154)	4.02697893
44	positive regulation of catecholamine secretion (GO:0033605)	4.01783101
45	chromosome condensation (GO:0030261)	4.00667998
46	meiotic cell cycle process (GO:1903046)	3.95690180
47	gamete generation (GO:0007276)	3.91322178
48	cellular biogenic amine biosynthetic process (GO:0042401)	3.91180473
49	single strand break repair (GO:0000012)	3.89568770
50	response to acidic pH (GO:0010447)	3.85239566
51	centriole replication (GO:0007099)	3.83957594
52	regulation of cilium movement (GO:0003352)	3.77619257
53	amine biosynthetic process (GO:0009309)	3.76629696
54	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.76171621
55	cilium or flagellum-dependent cell motility (GO:0001539)	3.75728896
56	protein neddylation (GO:0045116)	3.75598182
57	centriole assembly (GO:0098534)	3.71937223
58	meiotic cell cycle (GO:0051321)	3.66790457
59	epithelial cilium movement (GO:0003351)	3.66465272
60	cellular ketone body metabolic process (GO:0046950)	3.65836556
61	negative regulation of histone methylation (GO:0031061)	3.65775315
62	female gamete generation (GO:0007292)	3.52937484
63	negative regulation of inclusion body assembly (GO:0090084)	3.49147703
64	ketone body metabolic process (GO:1902224)	3.48953658
65	organic cation transport (GO:0015695)	3.46557640
66	histone H3-K9 demethylation (GO:0033169)	3.46253612
67	polyamine metabolic process (GO:0006595)	3.35668809
68	regulation of cellular respiration (GO:0043457)	3.30593780
69	protein-DNA complex disassembly (GO:0032986)	3.27067995
70	nucleosome disassembly (GO:0006337)	3.27067995
71	proteasome assembly (GO:0043248)	3.25299193
72	coenzyme catabolic process (GO:0009109)	3.24644596
73	positive regulation of endothelial cell differentiation (GO:0045603)	3.24524755
74	poly(A)+ mRNA export from nucleus (GO:0016973)	3.23344758
75	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.18339143
76	multicellular organismal reproductive process (GO:0048609)	3.10515885
77	gene silencing by RNA (GO:0031047)	3.09689661
78	protein polymerization (GO:0051258)	3.09272749
79	cellular response to pH (GO:0071467)	3.05083888
80	microtubule polymerization or depolymerization (GO:0031109)	3.03187033
81	melanin biosynthetic process (GO:0042438)	3.02549638
82	oogenesis (GO:0048477)	2.99545477
83	thrombin receptor signaling pathway (GO:0070493)	2.98109824
84	cilium movement (GO:0003341)	2.97494665
85	acrosome assembly (GO:0001675)	2.97308019
86	regulation of female gonad development (GO:2000194)	2.94993366
87	regulation of DNA methylation (GO:0044030)	2.94030435
88	xenobiotic catabolic process (GO:0042178)	2.90026383
89	resolution of meiotic recombination intermediates (GO:0000712)	2.82279789
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.77806490
91	L-phenylalanine metabolic process (GO:0006558)	2.77806490
92	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.73399933
93	regulation of acrosome reaction (GO:0060046)	2.72563212
94	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.72365348
95	regulation of oxidative stress-induced neuron death (GO:1903203)	2.71281740
96	L-phenylalanine catabolic process (GO:0006559)	2.69985817
97	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.69985817
98	oocyte development (GO:0048599)	2.63330114
99	positive regulation of glycolytic process (GO:0045821)	2.63292732
100	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.62378831

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.65691949
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.35218699
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.10763232
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.24884531
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89787599
6	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.63856991
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35574246
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.34459400
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.28693181
10	NANOG_20526341_ChIP-Seq_ESCs_Human	2.15264056
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.14100479
12	IGF1R_20145208_ChIP-Seq_DFB_Human	1.98513652
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94589625
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.88332242
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.85456352
16	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.83834874
17	FUS_26573619_Chip-Seq_HEK293_Human	1.82625848
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79715024
19	ERA_21632823_ChIP-Seq_H3396_Human	1.78516688
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.78501795
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.76805317
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.69779714
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69779714
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.63713174
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58061087
26	ERG_20517297_ChIP-Seq_VCAP_Human	1.56874427
27	PHF8_20622853_ChIP-Seq_HELA_Human	1.53402831
28	RBPJ_21746931_ChIP-Seq_IB4_Human	1.52561306
29	TBL1_22424771_ChIP-Seq_293T_Human	1.47699361
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47538773
31	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.43941317
32	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.42131493
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41866512
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41866512
35	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.41149518
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.40551586
37	RAC3_21632823_ChIP-Seq_H3396_Human	1.39412543
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.37583603
39	SPI1_20517297_ChIP-Seq_HL60_Human	1.34336523
40	HOXB7_26014856_ChIP-Seq_BT474_Human	1.34330226
41	CTCF_20526341_ChIP-Seq_ESCs_Human	1.34087204
42	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.33795725
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.33399966
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31489024
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31489024
46	VDR_22108803_ChIP-Seq_LS180_Human	1.30793517
47	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.28918285
48	MYC_19829295_ChIP-Seq_ESCs_Human	1.28426143
49	NFYB_21822215_ChIP-Seq_K562_Human	1.27813828
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.27628962
51	AR_25329375_ChIP-Seq_VCAP_Human	1.27404648
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23058704
53	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.22182554
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21624994
55	STAT1_20625510_ChIP-Seq_HELA_Human	1.21363312
56	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.20906020
57	P300_27268052_Chip-Seq_Bcells_Human	1.20839161
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20741077
59	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.20525136
60	ETV1_20927104_ChIP-Seq_GIST48_Human	1.19298205
61	AR_21909140_ChIP-Seq_LNCAP_Human	1.17862392
62	E2F1_20622854_ChIP-Seq_HELA_Human	1.16113464
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15877795
64	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.15590442
65	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15286731
66	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14974451
67	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14729138
68	NFYA_21822215_ChIP-Seq_K562_Human	1.14396035
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13159609
70	GATA2_19941826_ChIP-Seq_K562_Human	1.12627042
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11862212
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.11325808
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10679730
74	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10487159
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10335409
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09744871
77	BCOR_27268052_Chip-Seq_Bcells_Human	1.09080843
78	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.08650943
79	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.08232305
80	SCL_19346495_ChIP-Seq_HPC-7_Human	1.06962589
81	P68_20966046_ChIP-Seq_HELA_Human	1.06324705
82	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.06211429
83	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.05766794
84	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.05744083
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05404826
86	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05112225
87	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04132233
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03984281
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.03518620
90	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02405286
91	P300_19829295_ChIP-Seq_ESCs_Human	1.01274161
92	GATA1_19941826_ChIP-Seq_K562_Human	1.01012834
93	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99523522
94	PHF8_20622854_ChIP-Seq_HELA_Human	0.99010327
95	MYC_18940864_ChIP-ChIP_HL60_Human	0.98510282
96	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97873699
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97480535
98	TAF15_26573619_Chip-Seq_HEK293_Human	0.97212232
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97020389
100	E2F7_22180533_ChIP-Seq_HELA_Human	0.96039303

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.47979820
2	MP0000372_irregular_coat_pigmentation	6.51543985
3	MP0008004_abnormal_stomach_pH	5.05218209
4	MP0003136_yellow_coat_color	4.61608674
5	MP0003718_maternal_effect	4.08677168
6	MP0008877_abnormal_DNA_methylation	3.43426617
7	MP0002132_abnormal_respiratory_system	3.22559270
8	MP0001929_abnormal_gametogenesis	3.19929020
9	MP0003698_abnormal_male_reproductive	3.14256793
10	MP0005464_abnormal_platelet_physiology	3.05443681
11	MP0005360_urolithiasis	2.74823425
12	MP0005174_abnormal_tail_pigmentation	2.63026076
13	MP0002210_abnormal_sex_determination	2.37668252
14	MP0002160_abnormal_reproductive_system	2.30322753
15	MP0005058_abnormal_lysosome_morphology	2.20719891
16	MP0008058_abnormal_DNA_repair	1.94735901
17	MP0003315_abnormal_perineum_morphology	1.89578894
18	MP0002161_abnormal_fertility/fecundity	1.89331965
19	MP0000015_abnormal_ear_pigmentation	1.88900310
20	MP0000653_abnormal_sex_gland	1.83029611
21	MP0001145_abnormal_male_reproductive	1.78457540
22	MP0004381_abnormal_hair_follicle	1.66768417
23	MP0009697_abnormal_copulation	1.63432816
24	MP0005394_taste/olfaction_phenotype	1.62723781
25	MP0005499_abnormal_olfactory_system	1.62723781
26	MP0005395_other_phenotype	1.62356178
27	MP0005187_abnormal_penis_morphology	1.61872576
28	MP0003693_abnormal_embryo_hatching	1.57684040
29	MP0008789_abnormal_olfactory_epithelium	1.51784479
30	MP0003879_abnormal_hair_cell	1.41549705
31	MP0002095_abnormal_skin_pigmentation	1.39892896
32	MP0006036_abnormal_mitochondrial_physio	1.36735342
33	MP0000678_abnormal_parathyroid_gland	1.31823769
34	MP0001664_abnormal_digestion	1.31698223
35	MP0005389_reproductive_system_phenotype	1.27318364
36	MP0005647_abnormal_sex_gland	1.25868219
37	MP0005646_abnormal_pituitary_gland	1.22957382
38	MP0004147_increased_porphyrin_level	1.19612670
39	MP0005171_absent_coat_pigmentation	1.16016144
40	MP0005084_abnormal_gallbladder_morpholo	1.12869278
41	MP0008932_abnormal_embryonic_tissue	1.09435334
42	MP0001984_abnormal_olfaction	1.07290559
43	MP0003077_abnormal_cell_cycle	1.05896717
44	MP0003699_abnormal_female_reproductive	1.05710135
45	MP0010234_abnormal_vibrissa_follicle	1.05065548
46	MP0006292_abnormal_olfactory_placode	1.00724309
47	MP0005423_abnormal_somatic_nervous	0.98734521
48	MP0008057_abnormal_DNA_replication	0.96959788
49	MP0005408_hypopigmentation	0.95645295
50	MP0010094_abnormal_chromosome_stability	0.95052542
51	MP0001905_abnormal_dopamine_level	0.93988929
52	MP0001188_hyperpigmentation	0.92073435
53	MP0002090_abnormal_vision	0.90507546
54	MP0010368_abnormal_lymphatic_system	0.89451027
55	MP0004019_abnormal_vitamin_homeostasis	0.88973500
56	MP0000465_gastrointestinal_hemorrhage	0.87719794
57	MP0001119_abnormal_female_reproductive	0.84383799
58	MP0010386_abnormal_urinary_bladder	0.83677569
59	MP0000230_abnormal_systemic_arterial	0.80971721
60	MP0005075_abnormal_melanosome_morpholog	0.79680208
61	MP0004036_abnormal_muscle_relaxation	0.78923867
62	MP0003111_abnormal_nucleus_morphology	0.78069865
63	MP0001730_embryonic_growth_arrest	0.74845074
64	MP0002877_abnormal_melanocyte_morpholog	0.73685845
65	MP0004957_abnormal_blastocyst_morpholog	0.73351759
66	MP0001661_extended_life_span	0.73020257
67	MP0004215_abnormal_myocardial_fiber	0.72560339
68	MP0001879_abnormal_lymphatic_vessel	0.71724235
69	MP0002938_white_spotting	0.71142641
70	MP0004085_abnormal_heartbeat	0.69266986
71	MP0001968_abnormal_touch/_nociception	0.69132898
72	MP0003186_abnormal_redox_activity	0.68344429
73	MP0000343_altered_response_to	0.67678281
74	MP0004084_abnormal_cardiac_muscle	0.66120082
75	MP0003045_fibrosis	0.65923941
76	MP0008995_early_reproductive_senescence	0.63449569
77	MP0001666_abnormal_nutrient_absorption	0.62650421
78	MP0000358_abnormal_cell_content/	0.61905280
79	MP0001765_abnormal_ion_homeostasis	0.61805654
80	MP0003806_abnormal_nucleotide_metabolis	0.57139417
81	MP0005670_abnormal_white_adipose	0.56129027
82	MP0010678_abnormal_skin_adnexa	0.55850302
83	MP0006276_abnormal_autonomic_nervous	0.55274574
84	MP0002102_abnormal_ear_morphology	0.54159433
85	MP0008775_abnormal_heart_ventricle	0.53645530
86	MP0005551_abnormal_eye_electrophysiolog	0.53506075
87	MP0005379_endocrine/exocrine_gland_phen	0.53192257
88	MP0008260_abnormal_autophagy	0.51592079
89	MP0002139_abnormal_hepatobiliary_system	0.51560553
90	MP0000631_abnormal_neuroendocrine_gland	0.51019277
91	MP0000383_abnormal_hair_follicle	0.50553632
92	MP0003638_abnormal_response/metabolism_	0.49955435
93	MP0008872_abnormal_physiological_respon	0.48964294
94	MP0002736_abnormal_nociception_after	0.46896771
95	MP0002163_abnormal_gland_morphology	0.46511603
96	MP0002272_abnormal_nervous_system	0.46484763
97	MP0001545_abnormal_hematopoietic_system	0.46091844
98	MP0005397_hematopoietic_system_phenotyp	0.46091844
99	MP0002735_abnormal_chemical_nociception	0.44236742
100	MP0006035_abnormal_mitochondrial_morpho	0.43774042

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	5.23788523
2	Infertility (HP:0000789)	5.20927002
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.04876192
4	Absent/shortened dynein arms (HP:0200106)	5.04876192
5	Abnormal ciliary motility (HP:0012262)	4.82676914
6	Menorrhagia (HP:0000132)	4.77608319
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.47716726
8	Male infertility (HP:0003251)	4.45110986
9	Petechiae (HP:0000967)	4.39832406
10	Hypoplasia of the uterus (HP:0000013)	4.11624265
11	Resting tremor (HP:0002322)	4.07304589
12	Abnormal spermatogenesis (HP:0008669)	4.00081195
13	Azoospermia (HP:0000027)	3.98781278
14	Increased mean platelet volume (HP:0011877)	3.91090858
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.82717135
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.82717135
17	Abnormality of lateral ventricle (HP:0030047)	3.75722165
18	Ventricular fibrillation (HP:0001663)	3.75049073
19	Purpura (HP:0000979)	3.57540281
20	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.54991352
21	Generalized aminoaciduria (HP:0002909)	3.49353146
22	Abnormal platelet volume (HP:0011876)	3.43798999
23	Gonadal dysgenesis (HP:0000133)	3.35717080
24	Hypophosphatemic rickets (HP:0004912)	3.29570719
25	Aplasia/hypoplasia of the uterus (HP:0008684)	3.13022118
26	Congenital sensorineural hearing impairment (HP:0008527)	3.06064442
27	Facial hemangioma (HP:0000329)	2.91435584
28	Hyperthyroidism (HP:0000836)	2.84236928
29	Epistaxis (HP:0000421)	2.83055601
30	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.82535927
31	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.74937662
32	Hypoplasia of the fovea (HP:0007750)	2.74937662
33	Hyperlipoproteinemia (HP:0010980)	2.71170077
34	Tubulointerstitial nephritis (HP:0001970)	2.62978015
35	Rhinitis (HP:0012384)	2.60230575
36	Papillary thyroid carcinoma (HP:0002895)	2.55800924
37	Reduced antithrombin III activity (HP:0001976)	2.49698537
38	Male pseudohermaphroditism (HP:0000037)	2.47050148
39	Severe visual impairment (HP:0001141)	2.45454928
40	Abnormality of the fovea (HP:0000493)	2.42698643
41	Sex reversal (HP:0012245)	2.42243600
42	Abnormal sex determination (HP:0012244)	2.42243600
43	Self-mutilation (HP:0000742)	2.40405053
44	White forelock (HP:0002211)	2.34291425
45	Abnormal auditory evoked potentials (HP:0006958)	2.31905427
46	Acanthocytosis (HP:0001927)	2.30785177
47	Poikilocytosis (HP:0004447)	2.26622699
48	Median cleft lip (HP:0000161)	2.25330554
49	Impaired platelet aggregation (HP:0003540)	2.24391525
50	Abnormal platelet function (HP:0011869)	2.24391525
51	Postural instability (HP:0002172)	2.23112153
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.20909927
53	Patchy hypopigmentation of hair (HP:0011365)	2.20718128
54	Cholecystitis (HP:0001082)	2.19118042
55	Abnormal gallbladder physiology (HP:0012438)	2.19118042
56	Thyroid carcinoma (HP:0002890)	2.17334378
57	Aplasia/Hypoplasia of the macula (HP:0008059)	2.15160261
58	Retinal atrophy (HP:0001105)	2.10865743
59	Osteomalacia (HP:0002749)	2.09609986
60	Gonadotropin excess (HP:0000837)	2.07816291
61	Renal Fanconi syndrome (HP:0001994)	2.07582084
62	Attenuation of retinal blood vessels (HP:0007843)	2.02591680
63	Paralysis (HP:0003470)	2.00906736
64	Nasal polyposis (HP:0100582)	2.00703673
65	Anhidrosis (HP:0000970)	2.00329468
66	Type II lissencephaly (HP:0007260)	1.99933534
67	Upper limb muscle weakness (HP:0003484)	1.98996246
68	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.94651634
69	Conjunctival telangiectasia (HP:0000524)	1.90713841
70	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.89425964
71	Spontaneous abortion (HP:0005268)	1.89084300
72	Truncus arteriosus (HP:0001660)	1.87805269
73	Gingival bleeding (HP:0000225)	1.83779766
74	Absent thumb (HP:0009777)	1.83379754
75	Rickets (HP:0002748)	1.83197771
76	Sensory axonal neuropathy (HP:0003390)	1.82812346
77	Anterior segment dysgenesis (HP:0007700)	1.82444236
78	Aplastic anemia (HP:0001915)	1.81045710
79	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.78290578
80	Rhabdomyolysis (HP:0003201)	1.77551932
81	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.77421803
82	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.77342415
83	Capillary hemangiomas (HP:0005306)	1.77183021
84	Impulsivity (HP:0100710)	1.77100730
85	Abnormality of the columella (HP:0009929)	1.75666485
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.72976444
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.72976444
88	Long clavicles (HP:0000890)	1.72523753
89	Biliary tract neoplasm (HP:0100574)	1.71797962
90	Retinal dysplasia (HP:0007973)	1.70604280
91	Chromsome breakage (HP:0040012)	1.69404398
92	Hypoplastic ischia (HP:0003175)	1.68026966
93	Syncope (HP:0001279)	1.66684165
94	Dyschromatopsia (HP:0007641)	1.66365043
95	Wrist flexion contracture (HP:0001239)	1.65476323
96	Cerebral hypomyelination (HP:0006808)	1.64282129
97	Abnormal large intestine physiology (HP:0012700)	1.63338477
98	Abnormality of the preputium (HP:0100587)	1.62305525
99	Ileus (HP:0002595)	1.60937743
100	Tinnitus (HP:0000360)	1.60673968

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.39848354
2	MARK3	4.55800796
3	MYLK	3.88017517
4	ZAK	3.50640663
5	STK16	3.08856924
6	ARAF	2.65903052
7	EIF2AK1	2.59661240
8	TLK1	2.41409679
9	MST4	2.37797674
10	PLK4	2.29872466
11	MAP3K9	2.08189018
12	BMPR1B	2.04449060
13	MATK	1.87340048
14	EIF2AK3	1.82153012
15	PTK2B	1.72714796
16	PLK2	1.63248156
17	ILK	1.58313719
18	NEK2	1.57006524
19	RIPK4	1.56648860
20	CDK3	1.55776985
21	BMX	1.53913291
22	MAP4K2	1.51119783
23	PNCK	1.48510234
24	RPS6KA5	1.45836780
25	BRAF	1.39609089
26	PAK1	1.34603674
27	KSR2	1.34501164
28	MAP3K13	1.29551926
29	MAPKAPK3	1.27582321
30	TESK1	1.19479961
31	AURKA	1.16766402
32	STK3	1.15939900
33	STK38	1.15445384
34	LATS1	1.04525752
35	TTK	1.00559781
36	BMPR2	0.99509782
37	PKN1	0.98592738
38	CDK7	0.92605783
39	LATS2	0.91549279
40	RAF1	0.88289642
41	PIK3CG	0.88108085
42	STK38L	0.87821937
43	MET	0.84031811
44	NEK6	0.80640234
45	VRK1	0.78429142
46	PLK1	0.75244444
47	FRK	0.72095869
48	TESK2	0.69871594
49	PDPK1	0.69554028
50	BTK	0.66410685
51	TAOK3	0.65681868
52	PBK	0.64703096
53	PRKG1	0.63037058
54	CDC7	0.62400823
55	PDK1	0.62173371
56	WEE1	0.61044764
57	TEC	0.60410693
58	DDR2	0.59848234
59	GRK5	0.59751180
60	CDK14	0.59459031
61	PLK3	0.58251368
62	FGR	0.57856883
63	MOS	0.56085731
64	CDK9	0.54335916
65	WNK1	0.53417895
66	DAPK3	0.51306081
67	PDK2	0.50509092
68	PAK2	0.50261929
69	TNIK	0.50037282
70	BRSK2	0.46609874
71	AKT2	0.45751642
72	PIM1	0.44726790
73	CDK8	0.39775322
74	MAP3K5	0.39724514
75	STK4	0.39660190
76	MST1R	0.39543202
77	ROCK1	0.38293739
78	CDK12	0.38145381
79	ADRBK2	0.37669233
80	NUAK1	0.37638123
81	ATM	0.36904681
82	MAP3K12	0.36481479
83	NTRK1	0.36048349
84	CSNK1G3	0.35572574
85	INSRR	0.34896449
86	AKT3	0.34599283
87	PRKCQ	0.34335237
88	BRSK1	0.32682872
89	MAP3K8	0.32523710
90	CHEK1	0.32106783
91	WNK4	0.31960166
92	GRK6	0.31772585
93	PRKACB	0.31698233
94	STK24	0.31413848
95	KSR1	0.30232417
96	CSNK1G1	0.30197794
97	RET	0.30189008
98	MAPK13	0.26511142
99	CHEK2	0.25209429
100	MAP3K1	0.24812867

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	5.70812599
2	Gap junction_Homo sapiens_hsa04540	3.42966154
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.30696802
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.84392991
5	Basal transcription factors_Homo sapiens_hsa03022	2.77838789
6	Mismatch repair_Homo sapiens_hsa03430	2.75302824
7	Olfactory transduction_Homo sapiens_hsa04740	2.42698672
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.27932448
9	Butanoate metabolism_Homo sapiens_hsa00650	2.27399613
10	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.09887278
11	Oocyte meiosis_Homo sapiens_hsa04114	1.98055943
12	Propanoate metabolism_Homo sapiens_hsa00640	1.83733312
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.79961884
14	RNA transport_Homo sapiens_hsa03013	1.77645667
15	Alcoholism_Homo sapiens_hsa05034	1.74040394
16	Glutathione metabolism_Homo sapiens_hsa00480	1.65533870
17	Apoptosis_Homo sapiens_hsa04210	1.63347843
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.62079330
19	Fatty acid elongation_Homo sapiens_hsa00062	1.58854596
20	DNA replication_Homo sapiens_hsa03030	1.55453999
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.54035551
22	Phagosome_Homo sapiens_hsa04145	1.52022475
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.48521563
24	Platelet activation_Homo sapiens_hsa04611	1.48476986
25	Cell cycle_Homo sapiens_hsa04110	1.37674195
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.36582421
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36258514
28	Parkinsons disease_Homo sapiens_hsa05012	1.33417616
29	Regulation of autophagy_Homo sapiens_hsa04140	1.32875771
30	Purine metabolism_Homo sapiens_hsa00230	1.24742409
31	Homologous recombination_Homo sapiens_hsa03440	1.24116385
32	RNA degradation_Homo sapiens_hsa03018	1.23523892
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22996014
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.19902980
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.15992723
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14921948
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14003746
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.11942400
39	RNA polymerase_Homo sapiens_hsa03020	1.10427758
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08663266
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.04793228
42	Huntingtons disease_Homo sapiens_hsa05016	1.04375069
43	Base excision repair_Homo sapiens_hsa03410	0.99579717
44	Sulfur relay system_Homo sapiens_hsa04122	0.99485516
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.94108291
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92804417
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.90341177
48	Proteasome_Homo sapiens_hsa03050	0.88561746
49	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87881302
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87312155
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86860621
52	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85539240
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85048603
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.84359640
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.83533515
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72254080
57	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71806372
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70330531
59	One carbon pool by folate_Homo sapiens_hsa00670	0.69230714
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.67699542
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65855352
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65374392
63	Circadian rhythm_Homo sapiens_hsa04710	0.65300173
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63540798
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60482760
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59541724
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.58449018
68	Phototransduction_Homo sapiens_hsa04744	0.57421762
69	Taste transduction_Homo sapiens_hsa04742	0.55502136
70	Metabolic pathways_Homo sapiens_hsa01100	0.54357183
71	Folate biosynthesis_Homo sapiens_hsa00790	0.53752855
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53292767
73	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49628610
74	Caffeine metabolism_Homo sapiens_hsa00232	0.49277923
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.47774268
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47608415
77	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45838730
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.44963701
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.42397971
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42127920
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42075871
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.41971030
83	Serotonergic synapse_Homo sapiens_hsa04726	0.41923126
84	Fatty acid degradation_Homo sapiens_hsa00071	0.41263832
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.40903061
86	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.39782707
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38012078
88	Endocytosis_Homo sapiens_hsa04144	0.36722011
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35772235
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.33623560
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32897228
92	Thyroid cancer_Homo sapiens_hsa05216	0.30246181
93	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.25522864
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25464710
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.25053871
96	Endometrial cancer_Homo sapiens_hsa05213	0.24654689
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.24491952
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.24083565
99	Peroxisome_Homo sapiens_hsa04146	0.23420995
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.21599012

TP53TG3C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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