ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.04127470
2	acrosome reaction (GO:0007340)	8.13077085
3	sperm motility (GO:0030317)	7.96983624
4	plasma membrane fusion (GO:0045026)	6.92532628
5	male meiosis (GO:0007140)	6.87710536
6	multicellular organism reproduction (GO:0032504)	6.36224998
7	binding of sperm to zona pellucida (GO:0007339)	6.14598366
8	sperm-egg recognition (GO:0035036)	5.95888076
9	spermatid development (GO:0007286)	5.74368522
10	microtubule depolymerization (GO:0007019)	5.67343744
11	piRNA metabolic process (GO:0034587)	5.44710730
12	synapsis (GO:0007129)	5.39074135
13	reproduction (GO:0000003)	5.24370940
14	motile cilium assembly (GO:0044458)	5.14106952
15	polyamine biosynthetic process (GO:0006596)	5.00787700
16	male meiosis I (GO:0007141)	4.98497251
17	chromosome organization involved in meiosis (GO:0070192)	4.97728001
18	synaptonemal complex assembly (GO:0007130)	4.93817572
19	cell-cell recognition (GO:0009988)	4.89941561
20	axonemal dynein complex assembly (GO:0070286)	4.89113239
21	calcium ion-dependent exocytosis (GO:0017156)	4.73031112
22	meiosis I (GO:0007127)	4.68059847
23	rRNA methylation (GO:0031167)	4.62868229
24	regulation of meiosis I (GO:0060631)	4.60203771
25	synaptonemal complex organization (GO:0070193)	4.58519976
26	cellular ketone body metabolic process (GO:0046950)	4.56606050
27	positive regulation of catecholamine secretion (GO:0033605)	4.50248605
28	sperm capacitation (GO:0048240)	4.49337624
29	DNA methylation involved in gamete generation (GO:0043046)	4.42348393
30	response to pheromone (GO:0019236)	4.35381212
31	single fertilization (GO:0007338)	4.30273171
32	thrombin receptor signaling pathway (GO:0070493)	4.26743784
33	negative regulation of norepinephrine secretion (GO:0010700)	4.23485193
34	ketone body metabolic process (GO:1902224)	4.23315513
35	spermatid nucleus differentiation (GO:0007289)	4.21599507
36	meiotic nuclear division (GO:0007126)	4.20534042
37	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.14766772
38	spermatogenesis (GO:0007283)	4.12787363
39	male gamete generation (GO:0048232)	4.11848905
40	regulation of cilium movement (GO:0003352)	4.09634371
41	protein neddylation (GO:0045116)	4.08780177
42	positive regulation of endothelial cell differentiation (GO:0045603)	4.05804721
43	microtubule polymerization or depolymerization (GO:0031109)	4.03627177
44	DNA packaging (GO:0006323)	3.98464185
45	regulation of female receptivity (GO:0045924)	3.98258934
46	negative regulation of heart rate (GO:0010459)	3.95357321
47	negative regulation of inclusion body assembly (GO:0090084)	3.94709579
48	single strand break repair (GO:0000012)	3.92285807
49	gamete generation (GO:0007276)	3.84020579
50	blood coagulation, intrinsic pathway (GO:0007597)	3.81401444
51	epithelial cilium movement (GO:0003351)	3.80533437
52	chromosome condensation (GO:0030261)	3.79919140
53	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.78359619
54	fertilization (GO:0009566)	3.75086480
55	germ cell development (GO:0007281)	3.73674493
56	negative regulation of platelet activation (GO:0010544)	3.73594838
57	cilium or flagellum-dependent cell motility (GO:0001539)	3.72928847
58	rRNA modification (GO:0000154)	3.67543893
59	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.66847354
60	coenzyme catabolic process (GO:0009109)	3.64165303
61	centriole replication (GO:0007099)	3.62422413
62	cellular biogenic amine biosynthetic process (GO:0042401)	3.59763941
63	regulation of platelet activation (GO:0010543)	3.57765348
64	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.55052239
65	relaxation of smooth muscle (GO:0044557)	3.54100402
66	neutrophil activation involved in immune response (GO:0002283)	3.52722410
67	amine biosynthetic process (GO:0009309)	3.52008813
68	centriole assembly (GO:0098534)	3.50662497
69	regulation of oxidative phosphorylation (GO:0002082)	3.48964843
70	female mating behavior (GO:0060180)	3.44097549
71	negative regulation of response to food (GO:0032096)	3.41423367
72	negative regulation of appetite (GO:0032099)	3.41423367
73	organic cation transport (GO:0015695)	3.36851807
74	DNA synthesis involved in DNA repair (GO:0000731)	3.33639754
75	regulation of platelet aggregation (GO:0090330)	3.28854508
76	adenosine receptor signaling pathway (GO:0001973)	3.27813971
77	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.26008010
78	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.25441799
79	polyamine metabolic process (GO:0006595)	3.22683422
80	cilium movement (GO:0003341)	3.20494976
81	multicellular organismal reproductive process (GO:0048609)	3.07515818
82	xenobiotic catabolic process (GO:0042178)	3.04306274
83	response to acidic pH (GO:0010447)	3.00912092
84	meiotic cell cycle process (GO:1903046)	3.00619076
85	protein polyglutamylation (GO:0018095)	2.99420791
86	regulation of response to food (GO:0032095)	2.97481948
87	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97068396
88	lipoxygenase pathway (GO:0019372)	2.92785434
89	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.92674917
90	ether metabolic process (GO:0018904)	2.90142309
91	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.89390426
92	L-phenylalanine catabolic process (GO:0006559)	2.89390426
93	negative regulation of thymocyte apoptotic process (GO:0070244)	2.85743584
94	sexual reproduction (GO:0019953)	2.84529371
95	negative regulation of catecholamine secretion (GO:0033604)	2.83627733
96	protein targeting to Golgi (GO:0000042)	2.82153752
97	poly(A)+ mRNA export from nucleus (GO:0016973)	2.78931456
98	regulation of norepinephrine secretion (GO:0014061)	2.76584594
99	positive regulation of cAMP-mediated signaling (GO:0043950)	2.76309711
100	positive regulation of meiosis (GO:0045836)	2.75304568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.82483095
2	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	3.73215513
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.03400440
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54365902
5	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.52367384
6	VDR_22108803_ChIP-Seq_LS180_Human	2.31252791
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.23399316
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10711985
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08966668
10	NANOG_20526341_ChIP-Seq_ESCs_Human	2.03637716
11	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.03505952
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00513231
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.97568394
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.97054702
15	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.93382746
16	GATA1_19941826_ChIP-Seq_K562_Human	1.88692774
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84882440
18	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.83442600
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76980844
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.76980844
21	ERA_21632823_ChIP-Seq_H3396_Human	1.73489899
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72691816
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72691816
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.72085180
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70714334
26	GATA2_19941826_ChIP-Seq_K562_Human	1.70542903
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69681764
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68476047
29	AR_25329375_ChIP-Seq_VCAP_Human	1.68347880
30	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.67561523
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.67191806
32	SCL_19346495_ChIP-Seq_HPC-7_Human	1.65526854
33	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.63880460
34	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.63251294
35	RBPJ_21746931_ChIP-Seq_IB4_Human	1.60478336
36	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.59803084
37	TBL1_22424771_ChIP-Seq_293T_Human	1.59548871
38	FUS_26573619_Chip-Seq_HEK293_Human	1.59333200
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.59245166
40	PHF8_20622853_ChIP-Seq_HELA_Human	1.56834000
41	RAC3_21632823_ChIP-Seq_H3396_Human	1.56299150
42	NFYB_21822215_ChIP-Seq_K562_Human	1.53375088
43	CTCF_20526341_ChIP-Seq_ESCs_Human	1.51947562
44	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.51591264
45	OCT4_20526341_ChIP-Seq_ESCs_Human	1.50629266
46	ETV1_20927104_ChIP-Seq_GIST48_Human	1.49381965
47	HTT_18923047_ChIP-ChIP_STHdh_Human	1.46589466
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.46522949
49	STAT1_20625510_ChIP-Seq_HELA_Human	1.45126448
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.44648030
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.44542892
52	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.44135822
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44066968
54	SPI1_20517297_ChIP-Seq_HL60_Human	1.43874436
55	MYC_19829295_ChIP-Seq_ESCs_Human	1.40756992
56	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.40695248
57	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.40437569
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38119883
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38119883
60	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.37797451
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36905273
62	NFYA_21822215_ChIP-Seq_K562_Human	1.36542309
63	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.35506295
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.34046905
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33177407
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.32223632
67	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.30585403
68	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.29223963
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28333402
70	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.27995433
71	ZNF274_21170338_ChIP-Seq_K562_Hela	1.26696201
72	P300_19829295_ChIP-Seq_ESCs_Human	1.24195698
73	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.24115918
74	SPI1_23127762_ChIP-Seq_K562_Human	1.24108772
75	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.23610124
76	P300_27268052_Chip-Seq_Bcells_Human	1.21788891
77	BCOR_27268052_Chip-Seq_Bcells_Human	1.21346523
78	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.21223847
79	STAT3_23295773_ChIP-Seq_U87_Human	1.20349543
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20151491
81	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.19255746
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18452235
83	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18410318
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17645062
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14658619
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14566837
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14271682
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14147448
89	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.13994975
90	E2F1_20622854_ChIP-Seq_HELA_Human	1.13427912
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13280956
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13272875
93	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.12851289
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12304579
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12304579
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.11442282
97	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.11114320
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10835057
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08560454
100	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.08557626

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.59005465
2	MP0005464_abnormal_platelet_physiology	5.37327158
3	MP0008004_abnormal_stomach_pH	4.19045646
4	MP0003698_abnormal_male_reproductive	3.30568897
5	MP0002132_abnormal_respiratory_system	3.15539613
6	MP0001929_abnormal_gametogenesis	3.10580945
7	MP0003718_maternal_effect	3.01047486
8	MP0008877_abnormal_DNA_methylation	2.74487717
9	MP0003806_abnormal_nucleotide_metabolis	2.27021076
10	MP0005646_abnormal_pituitary_gland	2.24700448
11	MP0003136_yellow_coat_color	2.23963671
12	MP0009697_abnormal_copulation	2.05481772
13	MP0002160_abnormal_reproductive_system	2.05277021
14	MP0010386_abnormal_urinary_bladder	2.04413564
15	MP0002210_abnormal_sex_determination	2.03670568
16	MP0005083_abnormal_biliary_tract	2.02587419
17	MP0003879_abnormal_hair_cell	1.90833543
18	MP0005058_abnormal_lysosome_morphology	1.88935890
19	MP0001545_abnormal_hematopoietic_system	1.87862950
20	MP0005397_hematopoietic_system_phenotyp	1.87862950
21	MP0004084_abnormal_cardiac_muscle	1.78772657
22	MP0000230_abnormal_systemic_arterial	1.76326339
23	MP0001879_abnormal_lymphatic_vessel	1.75777084
24	MP0002161_abnormal_fertility/fecundity	1.72155750
25	MP0004036_abnormal_muscle_relaxation	1.66998567
26	MP0000653_abnormal_sex_gland	1.62821957
27	MP0008775_abnormal_heart_ventricle	1.62301135
28	MP0001145_abnormal_male_reproductive	1.59124805
29	MP0001968_abnormal_touch/_nociception	1.51788488
30	MP0000465_gastrointestinal_hemorrhage	1.49638579
31	MP0005389_reproductive_system_phenotype	1.44342643
32	MP0009278_abnormal_bone_marrow	1.42257767
33	MP0000372_irregular_coat_pigmentation	1.42159998
34	MP0009780_abnormal_chondrocyte_physiolo	1.37197374
35	MP0005647_abnormal_sex_gland	1.36351816
36	MP0002735_abnormal_chemical_nociception	1.33567570
37	MP0008872_abnormal_physiological_respon	1.32481629
38	MP0006276_abnormal_autonomic_nervous	1.29057549
39	MP0002736_abnormal_nociception_after	1.28558736
40	MP0001765_abnormal_ion_homeostasis	1.25912441
41	MP0005187_abnormal_penis_morphology	1.25830779
42	MP0000678_abnormal_parathyroid_gland	1.25542111
43	MP0004510_myositis	1.24188563
44	MP0002733_abnormal_thermal_nociception	1.21804949
45	MP0000015_abnormal_ear_pigmentation	1.20871914
46	MP0005174_abnormal_tail_pigmentation	1.19687043
47	MP0010368_abnormal_lymphatic_system	1.16657200
48	MP0005084_abnormal_gallbladder_morpholo	1.11484024
49	MP0006036_abnormal_mitochondrial_physio	1.10757836
50	MP0005670_abnormal_white_adipose	1.09195119
51	MP0000343_altered_response_to	1.08895643
52	MP0001661_extended_life_span	1.08687253
53	MP0001905_abnormal_dopamine_level	1.07983939
54	MP0003638_abnormal_response/metabolism_	1.06692546
55	MP0005167_abnormal_blood-brain_barrier	1.05629063
56	MP0003724_increased_susceptibility_to	1.04724776
57	MP0005395_other_phenotype	1.02178941
58	MP0004085_abnormal_heartbeat	1.01210004
59	MP0001664_abnormal_digestion	0.99969748
60	MP0001919_abnormal_reproductive_system	0.99078958
61	MP0005377_hearing/vestibular/ear_phenot	0.97416619
62	MP0003878_abnormal_ear_physiology	0.97416619
63	MP0005360_urolithiasis	0.96167103
64	MP0004215_abnormal_myocardial_fiber	0.95653531
65	MP0001970_abnormal_pain_threshold	0.93034044
66	MP0008995_early_reproductive_senescence	0.91096678
67	MP0005551_abnormal_eye_electrophysiolog	0.89660800
68	MP0005451_abnormal_body_composition	0.82456228
69	MP0001984_abnormal_olfaction	0.79717324
70	MP0008058_abnormal_DNA_repair	0.78784758
71	MP0001501_abnormal_sleep_pattern	0.78412654
72	MP0002653_abnormal_ependyma_morphology	0.78301493
73	MP0005645_abnormal_hypothalamus_physiol	0.77536500
74	MP0005379_endocrine/exocrine_gland_phen	0.74615863
75	MP0001756_abnormal_urination	0.73404501
76	MP0002127_abnormal_cardiovascular_syste	0.72878549
77	MP0005535_abnormal_body_temperature	0.69715073
78	MP0001485_abnormal_pinna_reflex	0.69480751
79	MP0005636_abnormal_mineral_homeostasis	0.68470559
80	MP0004019_abnormal_vitamin_homeostasis	0.67628192
81	MP0003699_abnormal_female_reproductive	0.63685894
82	MP0005409_darkened_coat_color	0.61735403
83	MP0002272_abnormal_nervous_system	0.61260143
84	MP0000358_abnormal_cell_content/	0.58254761
85	MP0001666_abnormal_nutrient_absorption	0.56941421
86	MP0009046_muscle_twitch	0.56479311
87	MP0000681_abnormal_thyroid_gland	0.56441260
88	MP0009642_abnormal_blood_homeostasis	0.55900313
89	MP0001119_abnormal_female_reproductive	0.55604163
90	MP0003011_delayed_dark_adaptation	0.55473334
91	MP0000249_abnormal_blood_vessel	0.54231239
92	MP0001963_abnormal_hearing_physiology	0.53578920
93	MP0002067_abnormal_sensory_capabilities	0.53502114
94	MP0002118_abnormal_lipid_homeostasis	0.48961233
95	MP0002837_dystrophic_cardiac_calcinosis	0.47684944
96	MP0002229_neurodegeneration	0.46130540
97	MP0002078_abnormal_glucose_homeostasis	0.44793631
98	MP0005253_abnormal_eye_physiology	0.43851916
99	MP0002102_abnormal_ear_morphology	0.43711083
100	MP0001764_abnormal_homeostasis	0.43316918

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	7.70830786
2	Menorrhagia (HP:0000132)	6.87808900
3	Petechiae (HP:0000967)	6.19558841
4	Increased mean platelet volume (HP:0011877)	5.86536463
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.61231017
6	Absent/shortened dynein arms (HP:0200106)	5.61231017
7	Purpura (HP:0000979)	5.46085089
8	Abnormal platelet volume (HP:0011876)	5.36718475
9	Abnormal ciliary motility (HP:0012262)	5.09933452
10	Abnormal respiratory motile cilium morphology (HP:0005938)	4.82197735
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.82197735
12	Epistaxis (HP:0000421)	4.78489813
13	Hyperlipoproteinemia (HP:0010980)	4.53257463
14	Abnormal respiratory motile cilium physiology (HP:0012261)	4.34549572
15	Severe visual impairment (HP:0001141)	4.25888793
16	Infertility (HP:0000789)	4.22106921
17	Resting tremor (HP:0002322)	4.17466842
18	Male infertility (HP:0003251)	3.99822850
19	Generalized aminoaciduria (HP:0002909)	3.88485182
20	Gingival bleeding (HP:0000225)	3.58417739
21	Abnormal pupillary function (HP:0007686)	3.46081580
22	Abnormality of lateral ventricle (HP:0030047)	3.45890963
23	Congenital sensorineural hearing impairment (HP:0008527)	3.44967965
24	Attenuation of retinal blood vessels (HP:0007843)	3.28328956
25	Impaired platelet aggregation (HP:0003540)	3.19922939
26	Abnormal platelet function (HP:0011869)	3.19922939
27	Poikilocytosis (HP:0004447)	3.16100835
28	Decreased central vision (HP:0007663)	3.12653770
29	Bony spicule pigmentary retinopathy (HP:0007737)	3.07782253
30	Hyperthyroidism (HP:0000836)	3.06405939
31	Acanthocytosis (HP:0001927)	3.01597195
32	Dyschromatopsia (HP:0007641)	2.97555758
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.96353470
34	Ventricular fibrillation (HP:0001663)	2.93639357
35	Azoospermia (HP:0000027)	2.93485502
36	Upper limb muscle weakness (HP:0003484)	2.84367970
37	Abnormal spermatogenesis (HP:0008669)	2.81151912
38	Rhinitis (HP:0012384)	2.80156401
39	Abnormality of the costochondral junction (HP:0000919)	2.74186962
40	Hypophosphatemic rickets (HP:0004912)	2.73501029
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.65004849
42	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.64461705
43	Tubulointerstitial nephritis (HP:0001970)	2.54804633
44	Osteomalacia (HP:0002749)	2.51878793
45	Abnormal auditory evoked potentials (HP:0006958)	2.42380547
46	Rickets (HP:0002748)	2.37938372
47	Renal Fanconi syndrome (HP:0001994)	2.36543671
48	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.35005865
49	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.32197454
50	Hypoplasia of the fovea (HP:0007750)	2.32197454
51	Paralysis (HP:0003470)	2.31498103
52	Xanthomatosis (HP:0000991)	2.29396815
53	Postural instability (HP:0002172)	2.28710294
54	Nasal polyposis (HP:0100582)	2.26953033
55	Enlarged epiphyses (HP:0010580)	2.24454737
56	Abnormality of macular pigmentation (HP:0008002)	2.18688299
57	Conjunctival telangiectasia (HP:0000524)	2.15087313
58	Abnormality of the fovea (HP:0000493)	2.12694246
59	Hypoplasia of the uterus (HP:0000013)	2.11751595
60	Bruising susceptibility (HP:0000978)	2.00284255
61	Male pseudohermaphroditism (HP:0000037)	1.98711442
62	Gonadal dysgenesis (HP:0000133)	1.95195075
63	Median cleft lip (HP:0000161)	1.94967289
64	Spontaneous abortion (HP:0005268)	1.94512050
65	Tinnitus (HP:0000360)	1.92630511
66	Clumsiness (HP:0002312)	1.89136998
67	Horizontal nystagmus (HP:0000666)	1.87867345
68	Atonic seizures (HP:0010819)	1.83217647
69	Abnormality of the nasal mucosa (HP:0000433)	1.82431168
70	Widely patent fontanelles and sutures (HP:0004492)	1.80433807
71	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.79994137
72	Hypergonadotropic hypogonadism (HP:0000815)	1.79636685
73	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.76528638
74	Chronic sinusitis (HP:0011109)	1.74314355
75	Spontaneous hematomas (HP:0007420)	1.72317232
76	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.69348769
77	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.69348769
78	Difficulty walking (HP:0002355)	1.66688055
79	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.64120616
80	Abnormality of renal resorption (HP:0011038)	1.62926297
81	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.62522357
82	Abnormality of dental color (HP:0011073)	1.60408207
83	Absent thumb (HP:0009777)	1.60348122
84	Portal hypertension (HP:0001409)	1.56239856
85	Abnormality of urine glucose concentration (HP:0011016)	1.56203500
86	Glycosuria (HP:0003076)	1.56203500
87	Protuberant abdomen (HP:0001538)	1.55340098
88	Bronchiectasis (HP:0002110)	1.55049575
89	Truncus arteriosus (HP:0001660)	1.54059887
90	Enlarged kidneys (HP:0000105)	1.51715292
91	Polydipsia (HP:0001959)	1.51673195
92	Abnormal drinking behavior (HP:0030082)	1.51673195
93	Hypoplastic ischia (HP:0003175)	1.50948976
94	Atelectasis (HP:0100750)	1.50642179
95	Hypoglycemic coma (HP:0001325)	1.50621463
96	Scotoma (HP:0000575)	1.49942969
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.49163356
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.47452422
99	Insulin-resistant diabetes mellitus (HP:0000831)	1.47261065
100	Potter facies (HP:0002009)	1.47091332

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.40844536
2	PLK4	3.56976927
3	MST4	3.52916181
4	MYLK	3.52367563
5	PNCK	3.27202607
6	PTK2B	2.86582336
7	MARK3	2.84732950
8	ZAK	2.69089308
9	MAP4K2	2.63229919
10	BMX	2.55020292
11	TESK1	2.39421233
12	FRK	2.27020918
13	PLK2	2.25342664
14	EIF2AK1	2.24921101
15	RIPK4	2.04885504
16	INSRR	1.98442754
17	ARAF	1.94407831
18	STK3	1.76046392
19	DDR2	1.75708512
20	ACVR1B	1.71638133
21	GRK5	1.62215976
22	TLK1	1.49969299
23	MAP3K2	1.47836123
24	BTK	1.39794949
25	ILK	1.39615325
26	PIK3CG	1.35767110
27	STK38	1.32447588
28	TEC	1.26686658
29	TAOK3	1.26447086
30	NUAK1	1.20168411
31	MAP3K9	1.19911523
32	PAK1	1.14927583
33	BMPR1B	1.12113155
34	FGR	1.08486537
35	ADRBK2	1.03822143
36	MAPK15	1.01025614
37	MAPKAPK3	0.95609903
38	MET	0.94850363
39	BMPR2	0.91939859
40	GRK6	0.91661356
41	TNK2	0.88610979
42	STK38L	0.86250005
43	NEK2	0.86081621
44	CSF1R	0.85107151
45	ICK	0.83751812
46	SYK	0.83199467
47	CDK3	0.79412273
48	TESK2	0.78071253
49	KSR2	0.77968920
50	BRAF	0.76247729
51	MAP3K1	0.76073260
52	PKN1	0.75335389
53	PRKG1	0.73421407
54	DAPK3	0.72855676
55	PDPK1	0.72659214
56	RPS6KA5	0.72373180
57	PDK1	0.71917579
58	NTRK3	0.69729448
59	WNK1	0.69007211
60	MST1R	0.67792279
61	MOS	0.66219360
62	RAF1	0.62598789
63	CDK7	0.61830297
64	RET	0.60547925
65	STK4	0.59694961
66	GRK1	0.57732961
67	DAPK2	0.55358355
68	WEE1	0.55254420
69	LATS1	0.52164310
70	LMTK2	0.50706103
71	MAP2K7	0.50399313
72	ROCK1	0.50157179
73	FER	0.49818155
74	WNK4	0.49520965
75	CDK8	0.49031258
76	CAMK1G	0.48397513
77	MAP3K13	0.46504676
78	MAP2K1	0.46220036
79	PRKG2	0.44485210
80	CDK14	0.42676486
81	AURKA	0.42290758
82	OBSCN	0.42050388
83	ZAP70	0.40772375
84	PRKCQ	0.37875533
85	CCNB1	0.32777573
86	HCK	0.32372742
87	CLK1	0.30817515
88	IKBKB	0.29249613
89	DYRK3	0.27952530
90	CDK19	0.27663615
91	MAP3K5	0.26189330
92	ADRBK1	0.25440481
93	LYN	0.24902436
94	MAPK11	0.24794639
95	PHKG1	0.24733571
96	PHKG2	0.24733571
97	MAPKAPK2	0.22548106
98	MATK	0.22322944
99	VRK1	0.21982576
100	MAPK13	0.20421963

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	4.01342308
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.98244147
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.63804852
4	Platelet activation_Homo sapiens_hsa04611	3.11862651
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.85863463
6	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.59038597
7	Gap junction_Homo sapiens_hsa04540	2.46274134
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.26578698
9	Butanoate metabolism_Homo sapiens_hsa00650	2.16543196
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.02063133
11	Mismatch repair_Homo sapiens_hsa03430	1.73355027
12	Regulation of autophagy_Homo sapiens_hsa04140	1.70312198
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.65691254
14	Glutathione metabolism_Homo sapiens_hsa00480	1.61394251
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.56675426
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52187103
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.49242496
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.49098381
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.48558729
20	Alcoholism_Homo sapiens_hsa05034	1.48382437
21	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.44454098
22	ECM-receptor interaction_Homo sapiens_hsa04512	1.42327013
23	Oocyte meiosis_Homo sapiens_hsa04114	1.40702879
24	Tyrosine metabolism_Homo sapiens_hsa00350	1.39552894
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.38498098
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28309124
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26708807
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.23456333
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22397055
30	Taste transduction_Homo sapiens_hsa04742	1.21287639
31	Phototransduction_Homo sapiens_hsa04744	1.18352437
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14681718
33	Serotonergic synapse_Homo sapiens_hsa04726	1.14459091
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12168518
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.12038868
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.06683586
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06000529
38	Basal transcription factors_Homo sapiens_hsa03022	1.05652751
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04849450
40	Homologous recombination_Homo sapiens_hsa03440	1.04019198
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01090044
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00570981
43	Phagosome_Homo sapiens_hsa04145	1.00458694
44	ABC transporters_Homo sapiens_hsa02010	0.98016444
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96347930
46	Sulfur metabolism_Homo sapiens_hsa00920	0.94674485
47	Retinol metabolism_Homo sapiens_hsa00830	0.94023516
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.91871555
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.91463667
50	Endocytosis_Homo sapiens_hsa04144	0.90497972
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89443862
52	Circadian entrainment_Homo sapiens_hsa04713	0.88558660
53	Purine metabolism_Homo sapiens_hsa00230	0.88078858
54	Phenylalanine metabolism_Homo sapiens_hsa00360	0.80221879
55	Sulfur relay system_Homo sapiens_hsa04122	0.77768157
56	Fatty acid elongation_Homo sapiens_hsa00062	0.75462369
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74143534
58	Pancreatic secretion_Homo sapiens_hsa04972	0.72365343
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69643504
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.68933262
61	Morphine addiction_Homo sapiens_hsa05032	0.67730197
62	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66794944
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.66574615
64	Renin-angiotensin system_Homo sapiens_hsa04614	0.65869084
65	Renin secretion_Homo sapiens_hsa04924	0.65475077
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64663269
67	GABAergic synapse_Homo sapiens_hsa04727	0.64265023
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59591913
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53977934
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.53958143
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.53402283
72	Apoptosis_Homo sapiens_hsa04210	0.51673559
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49873659
74	Fatty acid degradation_Homo sapiens_hsa00071	0.49873272
75	Folate biosynthesis_Homo sapiens_hsa00790	0.48962521
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47374050
77	Salivary secretion_Homo sapiens_hsa04970	0.43900420
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43361997
79	Gastric acid secretion_Homo sapiens_hsa04971	0.43047213
80	Arginine biosynthesis_Homo sapiens_hsa00220	0.41796072
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38033688
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.37959186
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37862080
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.36368252
85	Nicotine addiction_Homo sapiens_hsa05033	0.36303108
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35808195
87	Peroxisome_Homo sapiens_hsa04146	0.34981414
88	Metabolic pathways_Homo sapiens_hsa01100	0.34636642
89	Long-term depression_Homo sapiens_hsa04730	0.33863455
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33569968
91	Chemokine signaling pathway_Homo sapiens_hsa04062	0.32526832
92	Insulin secretion_Homo sapiens_hsa04911	0.32424770
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32415080
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31549616
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31011397
96	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.30389028
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29507463
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27911891
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.27231435
100	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.25854997

TP53TG3D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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