TP73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73416818
2epithelial cilium movement (GO:0003351)8.33379356
3left/right pattern formation (GO:0060972)7.03502624
4axoneme assembly (GO:0035082)6.20270049
5lung epithelium development (GO:0060428)5.02969139
6vitamin transmembrane transport (GO:0035461)5.00660081
7ventricular system development (GO:0021591)4.98522406
8primary alcohol catabolic process (GO:0034310)4.77291758
9microtubule bundle formation (GO:0001578)4.70319160
10negative regulation of T cell differentiation in thymus (GO:0033085)4.68047197
11tolerance induction (GO:0002507)4.51019068
12establishment of apical/basal cell polarity (GO:0035089)4.47674434
13microtubule depolymerization (GO:0007019)4.22015647
14establishment or maintenance of monopolar cell polarity (GO:0061339)4.07239320
15establishment of monopolar cell polarity (GO:0061162)4.07239320
16regulation of cilium movement (GO:0003352)4.05422371
17regulation of interleukin-13 production (GO:0032656)4.01189650
18left/right axis specification (GO:0070986)3.88741106
19intraciliary transport (GO:0042073)3.88006909
20centriole assembly (GO:0098534)3.84058425
21cilium organization (GO:0044782)3.80303399
22cilium assembly (GO:0042384)3.78745594
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.71869807
24ethanol metabolic process (GO:0006067)3.70324517
25regulation of chromatin binding (GO:0035561)3.68486386
26microtubule-based movement (GO:0007018)3.64532512
27diterpenoid biosynthetic process (GO:0016102)3.60981797
28ear development (GO:0043583)3.41156979
29protein insertion into membrane (GO:0051205)3.39145758
30glomerular epithelial cell development (GO:0072310)3.36351661
31sperm capacitation (GO:0048240)3.34148227
32microtubule polymerization or depolymerization (GO:0031109)3.29832351
33spliceosomal tri-snRNP complex assembly (GO:0000244)3.23866126
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.21851751
35establishment of planar polarity (GO:0001736)3.21458876
36establishment of tissue polarity (GO:0007164)3.21458876
37cytoplasmic microtubule organization (GO:0031122)3.18982722
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.09163112
39peptidyl-arginine omega-N-methylation (GO:0035247)3.02366697
40mitochondrion distribution (GO:0048311)2.97084683
41multicellular organismal water homeostasis (GO:0050891)2.96720854
42proline biosynthetic process (GO:0006561)2.95816308
43intracellular estrogen receptor signaling pathway (GO:0030520)2.94790652
44response to xenobiotic stimulus (GO:0009410)2.94295790
45pyrimidine-containing compound transmembrane transport (GO:0072531)2.92043054
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90308136
47base-excision repair, AP site formation (GO:0006285)2.85987556
48cellular component assembly involved in morphogenesis (GO:0010927)2.82830247
49T cell lineage commitment (GO:0002360)2.80711337
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77100629
51regulation of NFAT protein import into nucleus (GO:0051532)2.76707701
52regulation of interleukin-5 production (GO:0032674)2.73267321
53glucocorticoid receptor signaling pathway (GO:0042921)2.70161043
54regulation of microtubule depolymerization (GO:0031114)2.69569976
55establishment or maintenance of bipolar cell polarity (GO:0061245)2.68008417
56establishment or maintenance of apical/basal cell polarity (GO:0035088)2.68008417
57intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.67528603
58mitotic chromosome condensation (GO:0007076)2.67287590
59misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.66845558
60peptidyl-lysine dimethylation (GO:0018027)2.64632697
61cell projection assembly (GO:0030031)2.64272755
62regulation of RNA export from nucleus (GO:0046831)2.60599791
63protein localization to cilium (GO:0061512)2.56740918
64activation of Rac GTPase activity (GO:0032863)2.56642194
65semaphorin-plexin signaling pathway (GO:0071526)2.55584363
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55141987
67positive regulation of smoothened signaling pathway (GO:0045880)2.54497601
68terpenoid biosynthetic process (GO:0016114)2.54421579
69positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54273538
70negative regulation of immunoglobulin mediated immune response (GO:0002890)2.53818653
71negative regulation of B cell mediated immunity (GO:0002713)2.53818653
72nucleoside diphosphate phosphorylation (GO:0006165)2.52011392
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50637906
74regulation of water loss via skin (GO:0033561)2.47929130
75peptidyl-arginine N-methylation (GO:0035246)2.46766215
76peptidyl-arginine methylation (GO:0018216)2.46766215
77Golgi transport vesicle coating (GO:0048200)2.46195810
78COPI coating of Golgi vesicle (GO:0048205)2.46195810
79lateral ventricle development (GO:0021670)2.45570259
80microtubule-based process (GO:0007017)2.45321032
81establishment of skin barrier (GO:0061436)2.41751688
82regulation of response to osmotic stress (GO:0047484)2.41224081
83peptidyl-tyrosine autophosphorylation (GO:0038083)2.40551346
84pyrimidine nucleotide catabolic process (GO:0006244)2.40203839
85mRNA cleavage (GO:0006379)2.39840225
86apical protein localization (GO:0045176)2.36886820
87snRNA metabolic process (GO:0016073)2.35174457
88DNA replication initiation (GO:0006270)2.34823511
89negative regulation of microtubule depolymerization (GO:0007026)2.34236090
90positive regulation of gene expression, epigenetic (GO:0045815)2.33042636
91CDP-diacylglycerol biosynthetic process (GO:0016024)2.32430054
92natural killer cell mediated immunity (GO:0002228)2.31725015
93natural killer cell mediated cytotoxicity (GO:0042267)2.31725015
94negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31505118
95histone arginine methylation (GO:0034969)2.31229699
96negative regulation of viral release from host cell (GO:1902187)2.30516226
97axonemal dynein complex assembly (GO:0070286)15.3764421
98cilium or flagellum-dependent cell motility (GO:0001539)12.5229793
99motile cilium assembly (GO:0044458)11.5850834
100cilium movement (GO:0003341)10.3786432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.08722685
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.18294102
3* LXR_22292898_ChIP-Seq_THP-1_Human2.75748900
4MYC_22102868_ChIP-Seq_BL_Human2.67642903
5* VDR_21846776_ChIP-Seq_THP-1_Human2.64042639
6E2F7_22180533_ChIP-Seq_HELA_Human2.40428697
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35378899
8RACK7_27058665_Chip-Seq_MCF-7_Human2.32886467
9SMC4_20622854_ChIP-Seq_HELA_Human2.28485608
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26142226
11* P68_20966046_ChIP-Seq_HELA_Human2.24903678
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07560085
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.05944008
14ZNF263_19887448_ChIP-Seq_K562_Human2.05725979
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87632251
16CREB1_26743006_Chip-Seq_LNCaP_Human1.84562952
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82828524
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82709783
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81398344
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.78061683
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77117773
22XRN2_22483619_ChIP-Seq_HELA_Human1.76523980
23SA1_27219007_Chip-Seq_ERYTHROID_Human1.74686566
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70438491
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70334176
26CIITA_25753668_ChIP-Seq_RAJI_Human1.66197524
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.65496730
28SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.63674372
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62950074
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.60956367
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.60339582
32PHF8_20622854_ChIP-Seq_HELA_Human1.60133026
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56719097
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53844902
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.53358049
36BCOR_27268052_Chip-Seq_Bcells_Human1.52547381
37* CTCF_27219007_Chip-Seq_Bcells_Human1.51456052
38* DROSHA_22980978_ChIP-Seq_HELA_Human1.50863466
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49643008
40* ERG_21242973_ChIP-ChIP_JURKAT_Human1.49372713
41MAF_26560356_Chip-Seq_TH1_Human1.47487280
42TP63_22573176_ChIP-Seq_HFKS_Human1.46401974
43* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46321673
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45639317
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45115004
46* BCL6_27268052_Chip-Seq_Bcells_Human1.44591127
47TCF7_22412390_ChIP-Seq_EML_Mouse1.44196229
48TP53_22127205_ChIP-Seq_IMR90_Human1.43601076
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41384634
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40996504
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40053934
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39977075
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38431875
54KDM5A_27292631_Chip-Seq_BREAST_Human1.37967164
55E2F1_20622854_ChIP-Seq_HELA_Human1.36236827
56MAF_26560356_Chip-Seq_TH2_Human1.34531416
57KDM2B_26808549_Chip-Seq_DND41_Human1.34158121
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34153533
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33609536
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32983206
61* KDM2B_26808549_Chip-Seq_K562_Human1.31402674
62* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29379896
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28781723
64* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26564748
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26538558
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23626438
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.21973908
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20972680
69* NCOR1_26117541_ChIP-Seq_K562_Human1.20911104
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19310128
71RARA_24833708_ChIP-Seq_LIVER_Mouse1.18868013
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.17647352
73* CTCF_20526341_ChIP-Seq_ESCs_Human1.17055702
74SA1_27219007_Chip-Seq_Bcells_Human1.16016986
75* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15917088
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.15762977
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14390910
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12100591
79GABP_19822575_ChIP-Seq_HepG2_Human1.11049347
80* E2F1_21310950_ChIP-Seq_MCF-7_Human1.09933873
81P300_27268052_Chip-Seq_Bcells_Human1.09404968
82RARB_24833708_ChIP-Seq_LIVER_Mouse1.08829409
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07909784
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.06595567
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.06184834
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05818127
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05809740
88DCP1A_22483619_ChIP-Seq_HELA_Human1.03221036
89CTCF_21964334_Chip-Seq_Bcells_Human1.02769583
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01869059
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99163529
92UTX_26944678_Chip-Seq_JUKART_Human0.98984641
93CHD1_26751641_Chip-Seq_LNCaP_Human0.97643549
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94797932
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94783220
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94595783
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94308107
98DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93971635
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93594474
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93092954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology4.61986870
2MP0002653_abnormal_ependyma_morphology4.08371202
3MP0001346_abnormal_lacrimal_gland3.13952650
4MP0002249_abnormal_larynx_morphology2.90994750
5MP0000566_synostosis2.89074990
6MP0008875_abnormal_xenobiotic_pharmacok2.86846905
7MP0005394_taste/olfaction_phenotype2.53481572
8MP0005499_abnormal_olfactory_system2.53481572
9MP0008789_abnormal_olfactory_epithelium2.43582338
10MP0002132_abnormal_respiratory_system2.35711078
11MP0010234_abnormal_vibrissa_follicle2.32388256
12MP0000678_abnormal_parathyroid_gland2.28698298
13MP0002822_catalepsy2.14340498
14MP0003111_abnormal_nucleus_morphology2.09183888
15MP0004043_abnormal_pH_regulation2.06578208
16MP0004133_heterotaxia1.96558683
17MP0010094_abnormal_chromosome_stability1.95788274
18MP0005076_abnormal_cell_differentiation1.93324670
19MP0002796_impaired_skin_barrier1.91503800
20MP0005501_abnormal_skin_physiology1.89027195
21MP0002277_abnormal_respiratory_mucosa1.86104118
22MP0001984_abnormal_olfaction1.82671575
23MP0002098_abnormal_vibrissa_morphology1.75659024
24MP0001348_abnormal_lacrimal_gland1.71761071
25MP0003693_abnormal_embryo_hatching1.70079062
26MP0003453_abnormal_keratinocyte_physiol1.62823845
27MP0003077_abnormal_cell_cycle1.58651132
28MP0000383_abnormal_hair_follicle1.53824662
29MP0005220_abnormal_exocrine_pancreas1.53596370
30MP0008995_early_reproductive_senescence1.52112234
31MP0000681_abnormal_thyroid_gland1.45661305
32MP0009333_abnormal_splenocyte_physiolog1.45313671
33MP0010030_abnormal_orbit_morphology1.43664009
34MP0010678_abnormal_skin_adnexa1.40543322
35MP0003878_abnormal_ear_physiology1.37193957
36MP0005377_hearing/vestibular/ear_phenot1.37193957
37MP0005645_abnormal_hypothalamus_physiol1.28783313
38MP0004264_abnormal_extraembryonic_tissu1.25752119
39MP0001849_ear_inflammation1.25068751
40MP0001188_hyperpigmentation1.23028456
41MP0004782_abnormal_surfactant_physiolog1.21825279
42MP0000579_abnormal_nail_morphology1.20335808
43MP0003786_premature_aging1.18817390
44MP0000350_abnormal_cell_proliferation1.13060038
45MP0004858_abnormal_nervous_system1.07143676
46MP0002909_abnormal_adrenal_gland1.06096190
47MP0000685_abnormal_immune_system1.04637359
48MP0002160_abnormal_reproductive_system1.04598404
49MP0000467_abnormal_esophagus_morphology0.99095624
50MP0010307_abnormal_tumor_latency0.97774027
51MP0004185_abnormal_adipocyte_glucose0.97770909
52MP0003045_fibrosis0.97735808
53MP0005451_abnormal_body_composition0.97035493
54MP0003763_abnormal_thymus_physiology0.96925484
55MP0001216_abnormal_epidermal_layer0.96141087
56MP0002168_other_aberrant_phenotype0.95180042
57MP0003861_abnormal_nervous_system0.94075777
58MP0004957_abnormal_blastocyst_morpholog0.92537584
59MP0001730_embryonic_growth_arrest0.91118339
60MP0008057_abnormal_DNA_replication0.90941303
61MP0000003_abnormal_adipose_tissue0.89688563
62MP0000733_abnormal_muscle_development0.88168919
63MP0004233_abnormal_muscle_weight0.87592165
64MP0000313_abnormal_cell_death0.87537673
65MP0001944_abnormal_pancreas_morphology0.85932227
66MP0005310_abnormal_salivary_gland0.85814683
67MP0002084_abnormal_developmental_patter0.83227998
68MP0003315_abnormal_perineum_morphology0.83154485
69MP0001873_stomach_inflammation0.82981982
70MP0000377_abnormal_hair_follicle0.82669751
71MP0001790_abnormal_immune_system0.81678984
72MP0005387_immune_system_phenotype0.81678984
73MP0003115_abnormal_respiratory_system0.81554416
74MP0002085_abnormal_embryonic_tissue0.81089845
75MP0009780_abnormal_chondrocyte_physiolo0.80972496
76MP0002877_abnormal_melanocyte_morpholog0.80740810
77MP0008932_abnormal_embryonic_tissue0.80045998
78MP0002080_prenatal_lethality0.79672410
79MP0002282_abnormal_trachea_morphology0.79512283
80MP0001270_distended_abdomen0.79243265
81MP0002019_abnormal_tumor_incidence0.78282645
82MP0000858_altered_metastatic_potential0.78245781
83MP0002233_abnormal_nose_morphology0.76189143
84MP0002092_abnormal_eye_morphology0.74706623
85MP0003656_abnormal_erythrocyte_physiolo0.74447943
86MP0005671_abnormal_response_to0.73557366
87MP0010771_integument_phenotype0.73236048
88MP0003705_abnormal_hypodermis_morpholog0.72992777
89MP0001293_anophthalmia0.72782780
90MP0002234_abnormal_pharynx_morphology0.72114789
91MP0008260_abnormal_autophagy0.71795021
92MP0003942_abnormal_urinary_system0.70401248
93MP0003183_abnormal_peptide_metabolism0.70303239
94MP0001727_abnormal_embryo_implantation0.68290509
95MP0009931_abnormal_skin_appearance0.66769028
96MP0004381_abnormal_hair_follicle0.66445376
97MP0005621_abnormal_cell_physiology0.64771963
98MP0002116_abnormal_craniofacial_bone0.64689796
99MP0002089_abnormal_postnatal_growth/wei0.63954943
100MP0001672_abnormal_embryogenesis/_devel0.63670613

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.45320064
2Abnormal respiratory epithelium morphology (HP:0012253)9.45320064
3Abnormal respiratory motile cilium physiology (HP:0012261)9.25962650
4Absent/shortened dynein arms (HP:0200106)9.08259172
5Dynein arm defect of respiratory motile cilia (HP:0012255)9.08259172
6Abnormal ciliary motility (HP:0012262)8.98542888
7Rhinitis (HP:0012384)8.36289295
8Chronic bronchitis (HP:0004469)6.94291400
9Bronchiectasis (HP:0002110)6.85669318
10Nasal polyposis (HP:0100582)6.63010620
11Recurrent sinusitis (HP:0011108)5.25489238
12Abnormality of the nasal mucosa (HP:0000433)5.20601975
13Recurrent otitis media (HP:0000403)4.54128618
14Bronchitis (HP:0012387)4.28407651
15Male infertility (HP:0003251)4.16444907
16Infertility (HP:0000789)3.84312128
17Chronic sinusitis (HP:0011109)3.53162124
18Atelectasis (HP:0100750)3.51095079
19Occipital encephalocele (HP:0002085)2.91447164
20Chronic hepatic failure (HP:0100626)2.72492870
21Chronic otitis media (HP:0000389)2.70252119
22Recurrent bronchitis (HP:0002837)2.45612574
23Self-mutilation (HP:0000742)2.42190761
24Hyperactive renin-angiotensin system (HP:0000841)2.34451371
25Obstructive sleep apnea (HP:0002870)2.29373724
26Cystic liver disease (HP:0006706)2.24214422
27Bell-shaped thorax (HP:0001591)2.13733539
28Pancreatic fibrosis (HP:0100732)2.11786704
29True hermaphroditism (HP:0010459)2.09760554
30Lip pit (HP:0100267)2.07438852
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6378980
32Gastrointestinal stroma tumor (HP:0100723)1.97175456
33Abnormality of midbrain morphology (HP:0002418)1.95519298
34Molar tooth sign on MRI (HP:0002419)1.95519298
35Hyperacusis (HP:0010780)1.87268164
36Nephronophthisis (HP:0000090)1.86528594
37Postaxial foot polydactyly (HP:0001830)1.84648186
38Optic nerve coloboma (HP:0000588)1.79030947
39Broad distal phalanx of finger (HP:0009836)1.78958802
40Tubulointerstitial nephritis (HP:0001970)1.74657276
41Down-sloping shoulders (HP:0200021)1.72708678
42Squamous cell carcinoma (HP:0002860)1.71527497
43Sclerocornea (HP:0000647)1.70182828
44Flat acetabular roof (HP:0003180)1.70062370
45Anencephaly (HP:0002323)1.69649125
46Bifid scrotum (HP:0000048)1.67253823
47Fetal akinesia sequence (HP:0001989)1.65543433
48Dysmetric saccades (HP:0000641)1.62993064
49Abnormality of the aortic arch (HP:0012303)1.61225989
50Abnormality of the distal phalanges of the toes (HP:0010182)1.61070985
51Stridor (HP:0010307)1.60366922
52Congenital hepatic fibrosis (HP:0002612)1.57271953
53Facial cleft (HP:0002006)1.55480222
54Renal dysplasia (HP:0000110)1.54756875
55Abnormality of the fingertips (HP:0001211)1.51744546
56Aplasia/Hypoplasia of the sacrum (HP:0008517)1.50247829
57Renal salt wasting (HP:0000127)1.47736605
58Hand muscle atrophy (HP:0009130)1.45707746
59Preaxial hand polydactyly (HP:0001177)1.45674781
60Hyperkalemia (HP:0002153)1.44506570
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.43749155
62Truncus arteriosus (HP:0001660)1.38223701
63Polycystic kidney dysplasia (HP:0000113)1.37281058
64Pancreatic cysts (HP:0001737)1.37191763
65Carpal bone hypoplasia (HP:0001498)1.37044568
66Male pseudohermaphroditism (HP:0000037)1.35650979
67Septate vagina (HP:0001153)1.34700530
68Agammaglobulinemia (HP:0004432)1.34350511
69Abnormal ventriculo-arterial connection (HP:0011563)1.32005510
70Transposition of the great arteries (HP:0001669)1.32005510
71Abnormal connection of the cardiac segments (HP:0011545)1.32005510
72Abnormality of the renal medulla (HP:0100957)1.30478476
73Pili torti (HP:0003777)1.30285493
74Poikiloderma (HP:0001029)1.29679556
75Diaphragmatic weakness (HP:0009113)1.28799181
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27577192
77Tubular atrophy (HP:0000092)1.26785122
78Oligodontia (HP:0000677)1.23685052
79Colitis (HP:0002583)1.22330430
80Vertebral arch anomaly (HP:0008438)1.21665825
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.21383696
82Sparse scalp hair (HP:0002209)1.20949826
83Upper limb amyotrophy (HP:0009129)1.20656483
84Distal upper limb amyotrophy (HP:0007149)1.20656483
85Ulnar bowing (HP:0003031)1.19976050
86Hyponatremia (HP:0002902)1.19814118
87Popliteal pterygium (HP:0009756)1.19550616
88Abnormality of permanent molar morphology (HP:0011071)1.18560403
89Abnormality of the dental root (HP:0006486)1.18560403
90Taurodontia (HP:0000679)1.18560403
91Glucose intolerance (HP:0000833)1.17868757
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.17756707
93Oculomotor apraxia (HP:0000657)1.17094369
94IgA deficiency (HP:0002720)1.16866164
95Abnormality of the intervertebral disk (HP:0005108)1.14940444
96Onycholysis (HP:0001806)1.14881040
97Genetic anticipation (HP:0003743)1.12684292
98Abnormality of the columella (HP:0009929)1.11326638
99Flattened epiphyses (HP:0003071)1.10455556
100Emphysema (HP:0002097)1.09949754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.67122666
2SMG15.19208765
3PRPF4B4.36454153
4TRIB34.33409404
5EEF2K4.06451568
6EPHA23.83784647
7ICK2.86364411
8NME12.62388129
9SIK22.61121825
10CDK122.57097365
11MST41.89436620
12TAOK21.84658550
13MAPKAPK31.72115387
14IRAK31.62687152
15EPHA31.49645823
16MST1R1.49052681
17NME21.46109503
18TTK1.30117508
19SIK11.26995598
20CHEK21.19909951
21MAP3K101.17116287
22TLK11.15703042
23PRKCI1.14023788
24VRK21.07240364
25AURKA1.05596134
26MAPK111.05122578
27RPS6KB21.04336287
28CAMK1D1.04244899
29FGFR40.99361611
30BUB10.95594973
31CDK90.93960922
32CAMKK10.89736549
33CDK80.88153636
34MTOR0.86059624
35CDC70.85929212
36RIPK40.83881836
37CDK40.83722503
38MARK20.81804137
39CDK70.81526236
40TBK10.79323160
41CDK190.79132165
42CAMK1G0.78796173
43TAF10.78571581
44STK240.78172988
45BRD40.77222345
46ATR0.76204320
47IRAK40.74823042
48LRRK20.71257712
49PRKCH0.70530008
50SIK30.70114881
51PRKD30.69640128
52CDC42BPA0.67055781
53TESK20.65643289
54CHUK0.65575079
55MAP3K80.63268988
56NEK20.61054203
57MAPKAPK50.59697885
58PKN20.58085657
59HIPK20.57197561
60* CHEK10.56899793
61INSRR0.54819610
62BCR0.54152118
63MELK0.53718541
64PASK0.53299580
65AKT20.53109008
66PDPK10.52364712
67MAP3K20.51014219
68STK100.48269876
69IRAK20.47418561
70RPS6KA50.46995034
71PIM20.46828757
72MAP4K10.46588674
73PRKD20.43469457
74* CDK20.43324621
75RPS6KA20.42790226
76MAP3K70.42375659
77STK160.41727596
78ILK0.41510785
79AURKB0.40298394
80MAP3K60.37378916
81MAP3K130.35895007
82DAPK10.33535024
83CSK0.33224107
84PRKDC0.32530894
85* CDK10.29678754
86CSNK1A1L0.29256243
87STK40.28897310
88ARAF0.27917010
89ATM0.26183699
90GSK3B0.23369307
91MAPK140.23072001
92VRK10.21621282
93* PLK10.21599688
94IRAK10.19581237
95TYRO30.18533685
96NEK90.18346494
97CSNK1G30.18144171
98MAP2K20.18031610
99PAK40.17376762
100IKBKB0.17163121

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.92918653
2Base excision repair_Homo sapiens_hsa034103.07773401
3Notch signaling pathway_Homo sapiens_hsa043302.78097368
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.68751837
5DNA replication_Homo sapiens_hsa030302.65360992
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.20475456
7Tyrosine metabolism_Homo sapiens_hsa003502.19162946
8Sulfur relay system_Homo sapiens_hsa041222.14473917
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.02707411
10B cell receptor signaling pathway_Homo sapiens_hsa046621.81896794
11Huntingtons disease_Homo sapiens_hsa050161.72503559
12Systemic lupus erythematosus_Homo sapiens_hsa053221.68356448
13Histidine metabolism_Homo sapiens_hsa003401.59340934
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55585075
15Primary immunodeficiency_Homo sapiens_hsa053401.53952964
16Chemical carcinogenesis_Homo sapiens_hsa052041.52718095
17Allograft rejection_Homo sapiens_hsa053301.46503920
18mRNA surveillance pathway_Homo sapiens_hsa030151.45216298
19* p53 signaling pathway_Homo sapiens_hsa041151.44179658
20Cell cycle_Homo sapiens_hsa041101.42109031
21Lysine degradation_Homo sapiens_hsa003101.41327830
22Fructose and mannose metabolism_Homo sapiens_hsa000511.39209474
23Glutathione metabolism_Homo sapiens_hsa004801.34914534
24Chronic myeloid leukemia_Homo sapiens_hsa052201.34421972
25Nucleotide excision repair_Homo sapiens_hsa034201.34218065
26Herpes simplex infection_Homo sapiens_hsa051681.32605718
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32537041
28Sphingolipid metabolism_Homo sapiens_hsa006001.30682712
29Autoimmune thyroid disease_Homo sapiens_hsa053201.30681864
30Pancreatic cancer_Homo sapiens_hsa052121.29586112
31Viral myocarditis_Homo sapiens_hsa054161.28645181
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28205595
33Apoptosis_Homo sapiens_hsa042101.26080968
34Hepatitis C_Homo sapiens_hsa051601.24536433
35Pyrimidine metabolism_Homo sapiens_hsa002401.24399994
36Mismatch repair_Homo sapiens_hsa034301.23103752
37Non-small cell lung cancer_Homo sapiens_hsa052231.23075675
38Epstein-Barr virus infection_Homo sapiens_hsa051691.23049285
39Biosynthesis of amino acids_Homo sapiens_hsa012301.22539777
40beta-Alanine metabolism_Homo sapiens_hsa004101.22102580
41Alcoholism_Homo sapiens_hsa050341.18415370
42Spliceosome_Homo sapiens_hsa030401.13671496
43Viral carcinogenesis_Homo sapiens_hsa052031.09812036
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03317601
45Asthma_Homo sapiens_hsa053101.01981198
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00592959
47Influenza A_Homo sapiens_hsa051641.00108758
48Hedgehog signaling pathway_Homo sapiens_hsa043400.98772299
49Bladder cancer_Homo sapiens_hsa052190.97824891
50Basal cell carcinoma_Homo sapiens_hsa052170.97348952
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95606413
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90717502
53Type I diabetes mellitus_Homo sapiens_hsa049400.89953170
54Graft-versus-host disease_Homo sapiens_hsa053320.89790177
55Endometrial cancer_Homo sapiens_hsa052130.89186611
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88341487
57Prostate cancer_Homo sapiens_hsa052150.85865072
58HTLV-I infection_Homo sapiens_hsa051660.84089917
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.81861507
60Choline metabolism in cancer_Homo sapiens_hsa052310.80797682
61Colorectal cancer_Homo sapiens_hsa052100.80115887
62ErbB signaling pathway_Homo sapiens_hsa040120.79832107
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75881925
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.74626532
65Non-homologous end-joining_Homo sapiens_hsa034500.70917926
66* Neurotrophin signaling pathway_Homo sapiens_hsa047220.70759121
67Homologous recombination_Homo sapiens_hsa034400.69529646
68Small cell lung cancer_Homo sapiens_hsa052220.67944745
69Insulin signaling pathway_Homo sapiens_hsa049100.66589232
70Pentose phosphate pathway_Homo sapiens_hsa000300.65249810
71Hepatitis B_Homo sapiens_hsa051610.64482496
72Inositol phosphate metabolism_Homo sapiens_hsa005620.64188896
73ABC transporters_Homo sapiens_hsa020100.63911184
74Fanconi anemia pathway_Homo sapiens_hsa034600.63492972
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63233244
76Antigen processing and presentation_Homo sapiens_hsa046120.59365126
77RNA transport_Homo sapiens_hsa030130.56808186
78Arginine and proline metabolism_Homo sapiens_hsa003300.56209582
79Tight junction_Homo sapiens_hsa045300.56103483
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55406019
81mTOR signaling pathway_Homo sapiens_hsa041500.55257379
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55234131
83Acute myeloid leukemia_Homo sapiens_hsa052210.55129809
84Vibrio cholerae infection_Homo sapiens_hsa051100.54895175
85MicroRNAs in cancer_Homo sapiens_hsa052060.54122213
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52941595
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52755756
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52284863
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50530891
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50507278
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49748793
92Toxoplasmosis_Homo sapiens_hsa051450.46488146
93VEGF signaling pathway_Homo sapiens_hsa043700.45336760
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.44382373
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44257575
96AMPK signaling pathway_Homo sapiens_hsa041520.42626489
97Glioma_Homo sapiens_hsa052140.42008496
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41945687
99Type II diabetes mellitus_Homo sapiens_hsa049300.41044834
100Axon guidance_Homo sapiens_hsa043600.40806241

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