TP73-AS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.49687776
2paraxial mesoderm development (GO:0048339)4.41607312
3regulation of gene silencing by miRNA (GO:0060964)4.28728414
4regulation of gene silencing by RNA (GO:0060966)4.28728414
5regulation of posttranscriptional gene silencing (GO:0060147)4.28728414
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.23687523
7tongue development (GO:0043586)3.75912879
8negative regulation of histone methylation (GO:0031061)3.70922450
9pre-miRNA processing (GO:0031054)3.59799851
10protein-DNA complex disassembly (GO:0032986)3.50386668
11nucleosome disassembly (GO:0006337)3.50386668
12camera-type eye morphogenesis (GO:0048593)3.49512017
13outer ear morphogenesis (GO:0042473)3.48405651
14convergent extension (GO:0060026)3.46533459
15ribosomal small subunit biogenesis (GO:0042274)3.39684605
16maturation of SSU-rRNA (GO:0030490)3.37377870
17spinal cord development (GO:0021510)3.37059819
18cell migration in hindbrain (GO:0021535)3.33029201
19histone H3-K36 demethylation (GO:0070544)3.25363885
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.25297740
21neural tube development (GO:0021915)3.17089392
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.15389070
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.15389070
24regulation of translation, ncRNA-mediated (GO:0045974)3.15389070
25cytoplasmic mRNA processing body assembly (GO:0033962)3.06924972
26cranial nerve morphogenesis (GO:0021602)3.05798863
27lateral sprouting from an epithelium (GO:0060601)2.99757412
28proximal/distal pattern formation (GO:0009954)2.95191217
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93423223
30myofibril assembly (GO:0030239)2.92340949
31negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.91481602
32notochord development (GO:0030903)2.90153580
33head development (GO:0060322)2.89157118
34radial glial cell differentiation (GO:0060019)2.86075178
35pyrimidine nucleobase catabolic process (GO:0006208)2.85230642
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85228941
37hindbrain development (GO:0030902)2.85156627
38cardiac myofibril assembly (GO:0055003)2.80987914
39somatic stem cell division (GO:0048103)2.79881927
40adult heart development (GO:0007512)2.79671672
41viral transcription (GO:0019083)2.79393105
42establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.77804190
43regulation of NFAT protein import into nucleus (GO:0051532)2.75039510
44regulation of chromatin binding (GO:0035561)2.72419753
45regulation of histone H3-K4 methylation (GO:0051569)2.70766225
46regulation of oxidative stress-induced neuron death (GO:1903203)2.69769732
47positive regulation by host of viral transcription (GO:0043923)2.68829527
48DNA damage induced protein phosphorylation (GO:0006975)2.67311186
49axon extension involved in axon guidance (GO:0048846)2.65360925
50neuron projection extension involved in neuron projection guidance (GO:1902284)2.65360925
51chromatin assembly (GO:0031497)2.64639181
52positive regulation of protein kinase C signaling (GO:0090037)2.64293796
53lung-associated mesenchyme development (GO:0060484)2.64046596
54translational termination (GO:0006415)2.62705653
55heart valve formation (GO:0003188)2.62068162
563-UTR-mediated mRNA stabilization (GO:0070935)2.59187703
57neuronal stem cell maintenance (GO:0097150)2.57592135
58microtubule severing (GO:0051013)2.56950309
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.55930118
60histone lysine demethylation (GO:0070076)2.55406419
61negative regulation of gene expression, epigenetic (GO:0045814)2.55102593
62peripheral nervous system axon ensheathment (GO:0032292)2.53336047
63myelination in peripheral nervous system (GO:0022011)2.53336047
64embryonic camera-type eye development (GO:0031076)2.49237516
65RNA stabilization (GO:0043489)2.48394261
66mRNA stabilization (GO:0048255)2.48394261
67chromatin silencing (GO:0006342)2.48188421
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47517866
69regulation of ARF GTPase activity (GO:0032312)2.47154009
70otic vesicle formation (GO:0030916)2.46012377
71histone H3-K9 methylation (GO:0051567)2.43328254
72stress granule assembly (GO:0034063)2.42997133
73negative regulation of macroautophagy (GO:0016242)2.42049536
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.42039651
75cell proliferation in forebrain (GO:0021846)2.39825844
76cardiovascular system development (GO:0072358)2.39274424
77muscle cell fate commitment (GO:0042693)2.38998986
78mannose metabolic process (GO:0006013)2.38690585
79serine family amino acid catabolic process (GO:0009071)2.38565597
80histone demethylation (GO:0016577)2.35998663
81coronary vasculature morphogenesis (GO:0060977)2.35569572
82regulation of translational fidelity (GO:0006450)2.34603014
83positive regulation of gene expression, epigenetic (GO:0045815)2.34552194
84postsynaptic membrane organization (GO:0001941)2.34426336
85histone H3-K9 demethylation (GO:0033169)2.33999679
86positive regulation of CREB transcription factor activity (GO:0032793)2.32283359
87presynaptic membrane assembly (GO:0097105)2.31701017
88mRNA splice site selection (GO:0006376)2.31181624
89positive regulation of catecholamine secretion (GO:0033605)2.31073113
90presynaptic membrane organization (GO:0097090)2.29425951
91mRNA cleavage (GO:0006379)2.28318226
92regulation of histone H3-K9 methylation (GO:0051570)2.28223160
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26746899
94creatine metabolic process (GO:0006600)2.24466308
95negative regulation of striated muscle cell apoptotic process (GO:0010664)2.23766147
96regulation of histone methylation (GO:0031060)2.20908032
97regulation of non-canonical Wnt signaling pathway (GO:2000050)2.20443821
98regulation of mRNA stability (GO:0043488)2.19933873
99lymph vessel development (GO:0001945)2.18374175
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.18250902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80854419
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.41681452
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95902650
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.85251838
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70863545
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.40806130
7KDM2B_26808549_Chip-Seq_DND41_Human2.17357477
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16434415
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13045790
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12420578
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09241720
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.08003300
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05789144
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.03759139
15KDM2B_26808549_Chip-Seq_K562_Human2.02589267
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98970281
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98970281
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.96078099
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.95085871
20CTCF_27219007_Chip-Seq_Bcells_Human1.93847746
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.86374471
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83759895
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.83749934
24MYC_22102868_ChIP-Seq_BL_Human1.78205493
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.77519807
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74984816
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73951264
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73337076
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71933960
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70292025
31E2F7_22180533_ChIP-Seq_HELA_Human1.68829843
32MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.67874405
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67147473
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66369092
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.64800760
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64640775
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.63812095
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63803513
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.59761837
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58501511
41VDR_21846776_ChIP-Seq_THP-1_Human1.55122359
42LXR_22292898_ChIP-Seq_THP-1_Human1.54740946
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50659741
44P68_20966046_ChIP-Seq_HELA_Human1.45797437
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45216667
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.43427672
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42527890
48CREB1_26743006_Chip-Seq_LNCaP_Human1.41430369
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40682998
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.40409474
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.39012322
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.38616875
53AR_21572438_ChIP-Seq_LNCaP_Human1.37289426
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.37076837
55IGF1R_20145208_ChIP-Seq_DFB_Human1.35794644
56CIITA_25753668_ChIP-Seq_RAJI_Human1.34138225
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31412947
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29393552
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.27872086
60SMC4_20622854_ChIP-Seq_HELA_Human1.24294528
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22494073
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22494073
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22494073
64XRN2_22483619_ChIP-Seq_HELA_Human1.21474979
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21444863
66MAF_26560356_Chip-Seq_TH2_Human1.15912482
67TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15417230
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.14788916
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13938780
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13845945
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13532275
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12350863
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11974000
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08761994
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08004566
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06713756
77PHF8_20622854_ChIP-Seq_HELA_Human1.06491735
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06070891
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05567435
80DROSHA_22980978_ChIP-Seq_HELA_Human1.05179383
81RNF2_27304074_Chip-Seq_NSC_Mouse1.04564478
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.01616124
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01280747
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99806832
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99551284
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98331884
87SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97510181
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.97260375
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96554393
90THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96015689
91SA1_27219007_Chip-Seq_Bcells_Human0.95562549
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95067883
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94893859
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94765304
95OCT4_19829295_ChIP-Seq_ESCs_Human0.94507395
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93736318
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.93285742
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.92674775
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92458379
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92271482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.68792687
2MP0002249_abnormal_larynx_morphology2.64101230
3MP0000049_abnormal_middle_ear2.59202885
4MP0000537_abnormal_urethra_morphology2.41487843
5MP0003315_abnormal_perineum_morphology2.33108193
6MP0003122_maternal_imprinting2.13909332
7MP0003136_yellow_coat_color2.12726032
8MP0004859_abnormal_synaptic_plasticity2.07833618
9MP0010030_abnormal_orbit_morphology2.07581634
10MP0002653_abnormal_ependyma_morphology2.04817320
11MP0005499_abnormal_olfactory_system2.03188661
12MP0005394_taste/olfaction_phenotype2.03188661
13MP0008995_early_reproductive_senescence2.00245928
14MP0004145_abnormal_muscle_electrophysio1.94793955
15MP0003567_abnormal_fetal_cardiomyocyte1.85222519
16MP0000428_abnormal_craniofacial_morphol1.83729931
17MP0000778_abnormal_nervous_system1.78039124
18MP0003937_abnormal_limbs/digits/tail_de1.66904383
19MP0003283_abnormal_digestive_organ1.66501621
20MP0001849_ear_inflammation1.66347974
21MP0003942_abnormal_urinary_system1.63812271
22MP0000678_abnormal_parathyroid_gland1.62179859
23MP0005377_hearing/vestibular/ear_phenot1.61640175
24MP0003878_abnormal_ear_physiology1.61640175
25MP0001299_abnormal_eye_distance/1.59188158
26MP0003890_abnormal_embryonic-extraembry1.59024762
27MP0003119_abnormal_digestive_system1.58345451
28MP0008789_abnormal_olfactory_epithelium1.55706464
29MP0009278_abnormal_bone_marrow1.55190069
30MP0005503_abnormal_tendon_morphology1.51085492
31MP0009250_abnormal_appendicular_skeleto1.49931244
32MP0003385_abnormal_body_wall1.47023545
33MP0001188_hyperpigmentation1.46624015
34MP0001984_abnormal_olfaction1.46004093
35MP0003861_abnormal_nervous_system1.42162739
36MP0003938_abnormal_ear_development1.39806049
37MP0002116_abnormal_craniofacial_bone1.35305428
38MP0002638_abnormal_pupillary_reflex1.33280263
39MP0001502_abnormal_circadian_rhythm1.32830477
40MP0002697_abnormal_eye_size1.29678104
41MP0005187_abnormal_penis_morphology1.29535206
42MP0004147_increased_porphyrin_level1.28113028
43MP0001286_abnormal_eye_development1.28041173
44MP0000566_synostosis1.27647948
45MP0002108_abnormal_muscle_morphology1.27431286
46MP0004133_heterotaxia1.26674835
47MP0004084_abnormal_cardiac_muscle1.24968637
48MP0010368_abnormal_lymphatic_system1.24422150
49MP0001293_anophthalmia1.24392680
50MP0002092_abnormal_eye_morphology1.23207146
51MP0002233_abnormal_nose_morphology1.19994252
52MP0003935_abnormal_craniofacial_develop1.19462419
53MP0000955_abnormal_spinal_cord1.19001567
54MP0000631_abnormal_neuroendocrine_gland1.18770180
55MP0004885_abnormal_endolymph1.18084295
56MP0003121_genomic_imprinting1.15399154
57MP0003755_abnormal_palate_morphology1.14413732
58MP0002152_abnormal_brain_morphology1.13495478
59MP0002085_abnormal_embryonic_tissue1.12562749
60MP0001270_distended_abdomen1.10946580
61MP0002822_catalepsy1.06630148
62MP0004858_abnormal_nervous_system1.06292389
63MP0002084_abnormal_developmental_patter1.05598905
64MP0002160_abnormal_reproductive_system1.03804973
65MP0002127_abnormal_cardiovascular_syste1.02236527
66MP0000747_muscle_weakness1.00973555
67MP0000751_myopathy1.00629346
68MP0002114_abnormal_axial_skeleton1.00150329
69MP0002932_abnormal_joint_morphology0.98045141
70MP0010630_abnormal_cardiac_muscle0.97351574
71MP0006276_abnormal_autonomic_nervous0.96340325
72MP0004197_abnormal_fetal_growth/weight/0.96226366
73MP0003111_abnormal_nucleus_morphology0.95309009
74MP0003635_abnormal_synaptic_transmissio0.95151589
75MP0002111_abnormal_tail_morphology0.94649412
76MP0002081_perinatal_lethality0.93731448
77MP0005380_embryogenesis_phenotype0.92975120
78MP0001672_abnormal_embryogenesis/_devel0.92975120
79MP0004087_abnormal_muscle_fiber0.92551261
80MP0000432_abnormal_head_morphology0.92469158
81MP0002752_abnormal_somatic_nervous0.92217870
82MP0000759_abnormal_skeletal_muscle0.91364370
83MP0004036_abnormal_muscle_relaxation0.91162344
84MP0005369_muscle_phenotype0.90722394
85MP0002063_abnormal_learning/memory/cond0.90719740
86MP0004130_abnormal_muscle_cell0.90430255
87MP0004811_abnormal_neuron_physiology0.90381418
88MP0003646_muscle_fatigue0.90090539
89MP0006138_congestive_heart_failure0.88860223
90MP0001529_abnormal_vocalization0.88755497
91MP0001730_embryonic_growth_arrest0.87487352
92MP0004272_abnormal_basement_membrane0.87119001
93MP0003693_abnormal_embryo_hatching0.86357902
94MP0000534_abnormal_ureter_morphology0.86332252
95MP0003984_embryonic_growth_retardation0.85310503
96MP0002184_abnormal_innervation0.85076710
97MP0005391_vision/eye_phenotype0.84238418
98MP0002088_abnormal_embryonic_growth/wei0.82725031
99MP0003115_abnormal_respiratory_system0.81508648
100MP0002882_abnormal_neuron_morphology0.80918879

Predicted human phenotypes

RankGene SetZ-score
1High anterior hairline (HP:0009890)3.81519834
2Abnormality of the columella (HP:0009929)3.08502922
3Abnormality of the aortic arch (HP:0012303)3.03920786
4Turricephaly (HP:0000262)2.77631723
5Cerebellar dysplasia (HP:0007033)2.75715476
6Vitreoretinal degeneration (HP:0000655)2.55010281
7Retinal dysplasia (HP:0007973)2.54521174
8Thin ribs (HP:0000883)2.53954639
9Reticulocytopenia (HP:0001896)2.51547686
10Obstructive sleep apnea (HP:0002870)2.47050904
11Type II lissencephaly (HP:0007260)2.46041864
12Truncus arteriosus (HP:0001660)2.42753159
13Partial duplication of thumb phalanx (HP:0009944)2.42309717
14Abnormality of DNA repair (HP:0003254)2.40245282
15Abnormality of the 4th metacarpal (HP:0010012)2.35825018
16Ectopic kidney (HP:0000086)2.34635962
17Hepatoblastoma (HP:0002884)2.34549642
18Abnormality of cochlea (HP:0000375)2.32319804
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31498831
20Short 4th metacarpal (HP:0010044)2.31498831
21Broad thumb (HP:0011304)2.29989727
22Shallow orbits (HP:0000586)2.24540781
23Partial duplication of the phalanx of hand (HP:0009999)2.22237937
24Trigonocephaly (HP:0000243)2.21618323
25Skull defect (HP:0001362)2.19518252
26Calcaneovalgus deformity (HP:0001848)2.19234942
27Cutaneous finger syndactyly (HP:0010554)2.18956568
28Abnormality of the incisor (HP:0000676)2.17035472
29Abnormality of the diencephalon (HP:0010662)2.16038580
30Abnormality of the calcaneus (HP:0008364)2.14676568
31Cortical dysplasia (HP:0002539)2.14670406
32Broad phalanges of the hand (HP:0009768)2.13386796
33Renal dysplasia (HP:0000110)2.12068459
34Protruding tongue (HP:0010808)2.11390122
35Cutaneous syndactyly (HP:0012725)2.10938019
36Duplication of thumb phalanx (HP:0009942)2.10848440
37Septo-optic dysplasia (HP:0100842)2.09521776
38Hyperacusis (HP:0010780)2.08567551
39Deep palmar crease (HP:0006191)2.07332049
40Occipital encephalocele (HP:0002085)2.05095761
41Optic nerve coloboma (HP:0000588)2.03968265
42Rib fusion (HP:0000902)2.02729490
43Thoracic kyphosis (HP:0002942)2.02241795
44Midline defect of the nose (HP:0004122)2.01624629
45Broad finger (HP:0001500)2.00252700
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99867588
47Centrally nucleated skeletal muscle fibers (HP:0003687)1.99693756
48Morphological abnormality of the inner ear (HP:0011390)1.92980709
49Duplicated collecting system (HP:0000081)1.92128221
50Megalocornea (HP:0000485)1.91818843
51Preaxial foot polydactyly (HP:0001841)1.90676678
52Broad distal phalanx of finger (HP:0009836)1.90231013
53Bronchomalacia (HP:0002780)1.90138230
54Broad long bones (HP:0005622)1.88876991
55Bilateral microphthalmos (HP:0007633)1.88607181
56Abnormality of the ischium (HP:0003174)1.87740637
57Disproportionate tall stature (HP:0001519)1.86958039
58Renal duplication (HP:0000075)1.86574696
59Flat cornea (HP:0007720)1.86270790
60Hypoplasia of the brainstem (HP:0002365)1.85498190
61Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85498190
62Abnormality of the renal collecting system (HP:0004742)1.84689804
63Broad phalanx (HP:0006009)1.84381836
64Optic nerve hypoplasia (HP:0000609)1.83073418
65Morphological abnormality of the middle ear (HP:0008609)1.81959149
66Wide anterior fontanel (HP:0000260)1.81169762
67Sleep apnea (HP:0010535)1.79765295
68Neonatal short-limb short stature (HP:0008921)1.78817430
69Abnormality of reticulocytes (HP:0004312)1.78781978
70Abnormality of the pubic bones (HP:0003172)1.78607440
71Hypoplastic ischia (HP:0003175)1.77094499
72Deformed tarsal bones (HP:0008119)1.76618712
73Renovascular hypertension (HP:0100817)1.75991531
74Hypoventilation (HP:0002791)1.75685444
75Overriding aorta (HP:0002623)1.75542040
76Abnormal number of incisors (HP:0011064)1.74169847
77Abdominal situs inversus (HP:0003363)1.74028709
78Abnormality of abdominal situs (HP:0011620)1.74028709
79Coronal craniosynostosis (HP:0004440)1.73806737
80Abnormality of homocysteine metabolism (HP:0010919)1.73720869
81Homocystinuria (HP:0002156)1.73720869
82Hypoplasia of the maxilla (HP:0000327)1.70775301
83Slender long bone (HP:0003100)1.69822575
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69427475
85Insomnia (HP:0100785)1.69338443
86Rectal prolapse (HP:0002035)1.69104248
87Broad metatarsal (HP:0001783)1.68829699
88Long eyelashes (HP:0000527)1.67478708
89Facial hemangioma (HP:0000329)1.67293720
90Spinal rigidity (HP:0003306)1.66959548
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.66793893
92Genu recurvatum (HP:0002816)1.65535190
93Anophthalmia (HP:0000528)1.65069651
94Genetic anticipation (HP:0003743)1.65053317
95Elfin facies (HP:0004428)1.64037945
96Pointed chin (HP:0000307)1.63834215
97Abnormality of cells of the erythroid lineage (HP:0012130)1.63100147
98Abnormality of the parathyroid morphology (HP:0011766)1.62928761
99Abnormality of the shoulder girdle musculature (HP:0001435)1.62232924
100Hypoplasia of the pons (HP:0012110)1.61639314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.44823108
2EEF2K3.30176543
3TRIB32.78788813
4NEK22.78539402
5CDK122.75565021
6MAP3K102.57293828
7CDC71.84657724
8SIK21.77192339
9MAPK151.76458460
10MAP3K131.75160834
11ICK1.73569315
12TIE11.70917720
13MARK31.69561872
14FGFR21.63140196
15TNIK1.62867636
16NTRK11.62619690
17TYRO31.61389474
18OBSCN1.54298383
19CAMK1D1.43958181
20DYRK21.43312230
21BRD41.38067402
22LATS11.31608430
23CAMK1G1.30050100
24MTOR1.25163648
25MAP3K71.23862619
26NTRK21.23799727
27SGK4941.18101303
28SGK2231.18101303
29LATS21.16211558
30PRKD31.13169571
31MAP3K91.10024700
32EPHB21.09907793
33MARK21.07037413
34NME11.06508085
35CDK31.01979148
36DYRK30.99989183
37SMG10.99612362
38PASK0.99060489
39RPS6KC10.96564135
40RPS6KL10.96564135
41CDC42BPA0.95279398
42CSNK1A1L0.93528055
43RPS6KA60.91358500
44RPS6KA20.90985131
45MARK10.86642234
46CSNK1G30.85734466
47MKNK10.84821332
48CSNK1G20.80174247
49MAP2K70.79599586
50MAPK120.78655816
51NLK0.78078974
52HIPK20.77626967
53KSR20.76581220
54ARAF0.76409450
55CSNK1G10.76263581
56RPS6KA10.75061314
57PKN20.73806143
58SGK20.73424800
59PRKAA10.69805990
60WNK10.68611559
61MOS0.67020224
62PDGFRA0.64693928
63TGFBR10.63751326
64PAK20.63561276
65UHMK10.63421834
66DAPK20.62432663
67ATR0.62367083
68BMX0.61165793
69CDK90.60595039
70BRAF0.59948542
71CASK0.59697050
72BMPR1B0.59433811
73CLK10.57996499
74PRKD20.57654219
75DYRK1B0.57491702
76CDK190.57351097
77ATM0.55879748
78CAMK40.55813525
79PNCK0.55594465
80INSRR0.55446674
81CAMKK10.55254712
82AKT10.55083534
83FGFR40.54332869
84CDK20.53821823
85CDK40.53683809
86MAP3K40.53642715
87STK110.52580049
88WEE10.51455896
89MAPK100.51336925
90CAMK10.50981143
91PRKCH0.50591310
92EPHA30.50342448
93MAP2K40.49836423
94SRPK10.49338653
95MKNK20.48789133
96RPS6KB10.47947246
97GSK3B0.47472214
98RPS6KA50.47419273
99CDK10.46787752
100SIK10.46656248

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043402.32684380
2Notch signaling pathway_Homo sapiens_hsa043302.29136343
3Basal cell carcinoma_Homo sapiens_hsa052172.23893976
4mRNA surveillance pathway_Homo sapiens_hsa030152.09000250
5Lysine degradation_Homo sapiens_hsa003102.03832328
6Ribosome_Homo sapiens_hsa030101.99553510
7Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.81109625
8Olfactory transduction_Homo sapiens_hsa047401.71982830
9DNA replication_Homo sapiens_hsa030301.67048668
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59725757
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52337253
12Spliceosome_Homo sapiens_hsa030401.50412922
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50005883
14Axon guidance_Homo sapiens_hsa043601.49321453
15Gap junction_Homo sapiens_hsa045401.47236496
16Wnt signaling pathway_Homo sapiens_hsa043101.41608466
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34388220
18Oxytocin signaling pathway_Homo sapiens_hsa049211.32391031
19Melanogenesis_Homo sapiens_hsa049161.25301205
20Fanconi anemia pathway_Homo sapiens_hsa034601.25203655
21Dilated cardiomyopathy_Homo sapiens_hsa054141.21515545
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20556209
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20384477
24Hippo signaling pathway_Homo sapiens_hsa043901.18690621
25Nicotine addiction_Homo sapiens_hsa050331.17803847
26mTOR signaling pathway_Homo sapiens_hsa041501.12678453
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11395505
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11364129
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.10843738
30Insulin signaling pathway_Homo sapiens_hsa049101.10737830
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09594169
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08000666
33MicroRNAs in cancer_Homo sapiens_hsa052061.06636942
34Choline metabolism in cancer_Homo sapiens_hsa052311.06210485
35Colorectal cancer_Homo sapiens_hsa052101.05749092
36VEGF signaling pathway_Homo sapiens_hsa043701.05164152
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04830737
38Endometrial cancer_Homo sapiens_hsa052131.04446142
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02887571
40AMPK signaling pathway_Homo sapiens_hsa041521.01232722
41Cholinergic synapse_Homo sapiens_hsa047251.00766565
42Type II diabetes mellitus_Homo sapiens_hsa049301.00452067
43MAPK signaling pathway_Homo sapiens_hsa040100.99582739
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98872076
45RNA degradation_Homo sapiens_hsa030180.98471934
46Thyroid cancer_Homo sapiens_hsa052160.96266759
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96242760
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95158487
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.95019911
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94252876
51Sulfur relay system_Homo sapiens_hsa041220.93186934
52Prostate cancer_Homo sapiens_hsa052150.93055096
53Circadian entrainment_Homo sapiens_hsa047130.90557510
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90104997
55Cell cycle_Homo sapiens_hsa041100.90039360
56Selenocompound metabolism_Homo sapiens_hsa004500.88498562
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87893546
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.87440300
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85569252
60One carbon pool by folate_Homo sapiens_hsa006700.85021094
61Base excision repair_Homo sapiens_hsa034100.84777014
62RNA transport_Homo sapiens_hsa030130.84709840
63Phototransduction_Homo sapiens_hsa047440.83560193
64FoxO signaling pathway_Homo sapiens_hsa040680.82001579
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81848247
66Long-term potentiation_Homo sapiens_hsa047200.81227392
67Glucagon signaling pathway_Homo sapiens_hsa049220.79037518
68ErbB signaling pathway_Homo sapiens_hsa040120.78237290
69Adherens junction_Homo sapiens_hsa045200.77987526
70Cardiac muscle contraction_Homo sapiens_hsa042600.77276084
71Long-term depression_Homo sapiens_hsa047300.75913344
72ECM-receptor interaction_Homo sapiens_hsa045120.75174445
73Circadian rhythm_Homo sapiens_hsa047100.72593263
74GnRH signaling pathway_Homo sapiens_hsa049120.71955590
75Chronic myeloid leukemia_Homo sapiens_hsa052200.71521300
76Basal transcription factors_Homo sapiens_hsa030220.70471818
77Acute myeloid leukemia_Homo sapiens_hsa052210.69464082
78Morphine addiction_Homo sapiens_hsa050320.69318098
79Rap1 signaling pathway_Homo sapiens_hsa040150.69274738
80GABAergic synapse_Homo sapiens_hsa047270.68093020
81Ras signaling pathway_Homo sapiens_hsa040140.67686262
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.67536954
83Estrogen signaling pathway_Homo sapiens_hsa049150.65621679
84Melanoma_Homo sapiens_hsa052180.64733340
85Glioma_Homo sapiens_hsa052140.63742483
86Butanoate metabolism_Homo sapiens_hsa006500.63493637
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62456570
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62442082
89cAMP signaling pathway_Homo sapiens_hsa040240.61712581
90Calcium signaling pathway_Homo sapiens_hsa040200.61243481
91Oocyte meiosis_Homo sapiens_hsa041140.60140422
92Non-small cell lung cancer_Homo sapiens_hsa052230.59917589
93Pathways in cancer_Homo sapiens_hsa052000.59804156
94Dorso-ventral axis formation_Homo sapiens_hsa043200.59284760
95Nucleotide excision repair_Homo sapiens_hsa034200.58395733
96Tight junction_Homo sapiens_hsa045300.58109870
97TGF-beta signaling pathway_Homo sapiens_hsa043500.58006024
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56655802
99Glutamatergic synapse_Homo sapiens_hsa047240.56323867
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56143368

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