TPBG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spinal cord association neuron differentiation (GO:0021527)5.63716098
2negative regulation of cell fate specification (GO:0009996)5.50935291
3limb bud formation (GO:0060174)5.31177099
4midbrain development (GO:0030901)5.08098332
5establishment of tissue polarity (GO:0007164)4.80284341
6establishment of planar polarity (GO:0001736)4.80284341
7G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.76360524
8regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.62868603
9chondrocyte proliferation (GO:0035988)4.58145058
10hematopoietic stem cell proliferation (GO:0071425)4.49069958
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.39435878
12notochord development (GO:0030903)4.32073149
13positive regulation of catenin import into nucleus (GO:0035413)4.28746399
14axon extension involved in axon guidance (GO:0048846)4.28103795
15neuron projection extension involved in neuron projection guidance (GO:1902284)4.28103795
16cell proliferation involved in metanephros development (GO:0072203)4.24400509
17lateral sprouting from an epithelium (GO:0060601)4.21202320
18collagen fibril organization (GO:0030199)4.07681754
19chondrocyte development (GO:0002063)4.04996720
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.01038366
21artery development (GO:0060840)3.93572681
22regulation of cardioblast differentiation (GO:0051890)3.92024583
23paraxial mesoderm development (GO:0048339)3.91203018
24convergent extension (GO:0060026)3.90574653
25negative regulation of cell fate commitment (GO:0010454)3.89922022
26dorsal/ventral neural tube patterning (GO:0021904)3.87414926
27mesenchymal cell proliferation (GO:0010463)3.82100677
28dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.81672727
29mesenchymal-epithelial cell signaling (GO:0060638)3.78906824
30regulation of cell fate specification (GO:0042659)3.76649356
31post-anal tail morphogenesis (GO:0036342)3.76542782
32desmosome organization (GO:0002934)3.72454024
33lung-associated mesenchyme development (GO:0060484)3.72228918
34regulation of mesenchymal cell apoptotic process (GO:2001053)3.68283682
35outer ear morphogenesis (GO:0042473)3.63351057
36cell proliferation involved in kidney development (GO:0072111)3.58558026
37negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.57340889
38cell proliferation in forebrain (GO:0021846)3.56285489
39positive regulation of canonical Wnt signaling pathway (GO:0090263)3.43115325
40negative regulation of axon extension involved in axon guidance (GO:0048843)3.42633422
41lens fiber cell development (GO:0070307)3.42565272
42sequestering of extracellular ligand from receptor (GO:0035581)3.41736595
43lung epithelium development (GO:0060428)3.40320671
44neuron fate determination (GO:0048664)3.38917173
45cornea development in camera-type eye (GO:0061303)3.37159595
46myoblast fusion (GO:0007520)3.35531018
47negative regulation of axon guidance (GO:1902668)3.34364130
48metanephric mesenchyme development (GO:0072075)3.32556092
49branching involved in salivary gland morphogenesis (GO:0060445)3.30319658
50regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.28431133
51negative regulation of smooth muscle cell differentiation (GO:0051151)3.26769327
52negative chemotaxis (GO:0050919)3.25948463
53negative regulation of chondrocyte differentiation (GO:0032331)3.25819515
54cochlea morphogenesis (GO:0090103)3.24581820
55negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.23294417
56wound healing, spreading of epidermal cells (GO:0035313)3.22779839
57mesenchyme morphogenesis (GO:0072132)3.22219384
58dopaminergic neuron differentiation (GO:0071542)3.17008018
59embryonic forelimb morphogenesis (GO:0035115)3.16572748
60positive regulation of cardiac muscle cell differentiation (GO:2000727)3.16134662
61regulation of catenin import into nucleus (GO:0035412)3.15133687
62prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.14738479
63mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.13948920
64neural crest cell development (GO:0014032)3.11857819
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.11290015
66kidney mesenchyme development (GO:0072074)3.10128381
67establishment of apical/basal cell polarity (GO:0035089)3.10099566
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.09202024
69bone trabecula formation (GO:0060346)3.05136885
70protein heterotrimerization (GO:0070208)3.04480069
71embryonic skeletal joint morphogenesis (GO:0060272)3.04315709
72craniofacial suture morphogenesis (GO:0097094)3.02501471
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.01406039
74establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.00616109
75middle ear morphogenesis (GO:0042474)2.99130395
76hippo signaling (GO:0035329)2.98891902
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.97157324
78positive regulation of gastrulation (GO:2000543)2.96031597
79urogenital system development (GO:0001655)2.95260312
80forelimb morphogenesis (GO:0035136)2.94499418
81epithelial to mesenchymal transition (GO:0001837)2.94177958
82regulation of establishment of planar polarity (GO:0090175)2.93489175
83cell fate commitment involved in formation of primary germ layer (GO:0060795)2.91864708
84positive regulation of embryonic development (GO:0040019)2.90488333
85regulation of embryonic development (GO:0045995)2.90303911
86syncytium formation by plasma membrane fusion (GO:0000768)2.90267254
87negative regulation of embryonic development (GO:0045992)2.89815413
88cell surface receptor signaling pathway involved in heart development (GO:0061311)2.89451549
89inner ear morphogenesis (GO:0042472)2.88552606
90regulation of organ formation (GO:0003156)2.87916726
91canonical Wnt signaling pathway (GO:0060070)2.87370896
92regulation of gastrulation (GO:0010470)2.87298802
93cardiac epithelial to mesenchymal transition (GO:0060317)2.86742518
94negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.86698262
95apical protein localization (GO:0045176)2.86657151
96embryonic cranial skeleton morphogenesis (GO:0048701)2.86290636
97glomerular basement membrane development (GO:0032836)2.85985761
98pattern specification involved in kidney development (GO:0061004)2.83170221
99mammary gland development (GO:0030879)2.81726400
100positive regulation of mesenchymal cell proliferation (GO:0002053)2.81264600
101wound healing, spreading of cells (GO:0044319)2.79098587
102polarized epithelial cell differentiation (GO:0030859)2.78701743
103stem cell proliferation (GO:0072089)2.78235502
104gland morphogenesis (GO:0022612)2.77937573
105retinal ganglion cell axon guidance (GO:0031290)2.77435063
106positive regulation of smoothened signaling pathway (GO:0045880)2.76678030
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.74242906
108establishment of monopolar cell polarity (GO:0061162)2.74242906
109endodermal cell differentiation (GO:0035987)2.74206512
110non-canonical Wnt signaling pathway (GO:0035567)2.73744056
111heart valve morphogenesis (GO:0003179)2.73608067
112embryonic skeletal system development (GO:0048706)2.73337713
113branch elongation of an epithelium (GO:0060602)2.72668970
114eyelid development in camera-type eye (GO:0061029)2.72259599
115camera-type eye morphogenesis (GO:0048593)2.71636538
116endocardial cushion morphogenesis (GO:0003203)2.71541509
117mesodermal cell differentiation (GO:0048333)2.71303673
118regulation of axon guidance (GO:1902667)2.71015687
119negative regulation of cartilage development (GO:0061037)2.70959336
120regulation of mesoderm development (GO:2000380)2.68201382
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.68076614
122regulation of morphogenesis of a branching structure (GO:0060688)2.67893863
123regulation of axon extension involved in axon guidance (GO:0048841)2.67530803
124stem cell development (GO:0048864)2.67305079
125organ induction (GO:0001759)2.66254922
126renal system development (GO:0072001)2.64960737
127regulation of hair follicle development (GO:0051797)2.64951676
128lung lobe morphogenesis (GO:0060463)2.63337978
129regulation of mesenchymal cell proliferation (GO:0010464)2.63065152
130establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61856699
131establishment or maintenance of bipolar cell polarity (GO:0061245)2.61856699
132cranial suture morphogenesis (GO:0060363)2.60282092
133mesenchymal cell development (GO:0014031)2.59761174
134face development (GO:0060324)2.59556474
135cartilage morphogenesis (GO:0060536)2.59472127
136axis elongation (GO:0003401)2.59348029
137positive regulation of cardiac muscle tissue development (GO:0055025)2.59006428
138positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58865742
139mesoderm formation (GO:0001707)2.57728004
140positive regulation of Wnt signaling pathway (GO:0030177)2.57384487
141regulation of cell fate commitment (GO:0010453)2.56137860
142somatic stem cell division (GO:0048103)2.56003586
143negative regulation of catenin import into nucleus (GO:0035414)2.55586724
144mesenchymal to epithelial transition (GO:0060231)2.54606464
145positive regulation of neuroblast proliferation (GO:0002052)2.54033673
146hemidesmosome assembly (GO:0031581)2.53978692
147embryonic hindlimb morphogenesis (GO:0035116)2.53113869
148somite development (GO:0061053)2.53110350
149prostate gland epithelium morphogenesis (GO:0060740)2.53072810
150mesenchyme development (GO:0060485)2.52980359
151positive regulation of cartilage development (GO:0061036)2.52328468
152negative regulation of axon extension (GO:0030517)2.51576021
153regulation of heart morphogenesis (GO:2000826)2.51195945
154digestive tract morphogenesis (GO:0048546)2.50623635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.68840809
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.67526834
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19025546
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.96531744
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85666694
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.77272982
7TP53_20018659_ChIP-ChIP_R1E_Mouse2.48277393
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.48208013
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46394282
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46394282
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44668400
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44116322
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27345725
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26816326
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25349722
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24014359
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22794617
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19224494
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15631401
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.13141571
21EZH2_22144423_ChIP-Seq_EOC_Human2.07207343
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.02513788
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.99176047
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97947655
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95674167
26TP53_18474530_ChIP-ChIP_U2OS_Human1.93900928
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88791555
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.88407077
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86595357
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80313236
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79833534
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55466367
33* RING1B_27294783_Chip-Seq_NPCs_Mouse1.52593402
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50879002
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50834610
36RNF2_27304074_Chip-Seq_NSC_Mouse1.50595411
37TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.50379542
38* CJUN_26792858_Chip-Seq_BT549_Human1.49971399
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49316626
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.48647678
41GBX2_23144817_ChIP-Seq_PC3_Human1.48255974
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47575064
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43912327
44ZNF263_19887448_ChIP-Seq_K562_Human1.41820907
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40194869
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.39396487
47AR_21909140_ChIP-Seq_LNCAP_Human1.39137015
48* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38103511
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37061707
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35314762
51AR_21572438_ChIP-Seq_LNCaP_Human1.31443745
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.31145766
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.30674633
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29085445
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28942522
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27387018
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27376162
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27376162
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27314895
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27314895
61BRD4_25478319_ChIP-Seq_HGPS_Human1.25712250
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.23497973
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22832727
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20241990
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20104661
66TP53_16413492_ChIP-PET_HCT116_Human1.19715729
67TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18931053
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18086012
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.17330995
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16577655
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16000737
72FUS_26573619_Chip-Seq_HEK293_Human1.15659781
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.15005435
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14607248
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11181983
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10767110
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10702710
78CLOCK_20551151_ChIP-Seq_293T_Human1.10411536
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.10365317
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09324434
81* EWS_26573619_Chip-Seq_HEK293_Human1.07131559
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06677381
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05423889
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04025738
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.03686546
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03674626
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03450300
88P300_19829295_ChIP-Seq_ESCs_Human1.03126668
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02168558
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.00907955
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00604216
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.00205460
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.00027845
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99590719
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99280630
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98475087
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98048371
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97232716
99* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97211336
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96557859
101* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96106642
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95900333
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95650494
104* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95417134
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.94915912
106* SA1_22415368_ChIP-Seq_MEFs_Mouse0.94796319
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94520136
108RXR_22108803_ChIP-Seq_LS180_Human0.94197209
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93977575
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93089582
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92683550
112AHR_22903824_ChIP-Seq_MCF-7_Human0.91748269
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89573519
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88790330
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88790330
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88790330
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88723009
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87751785
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87209413
120UBF1/2_26484160_Chip-Seq_HMECs_Human0.86874685
121SOX2_20726797_ChIP-Seq_SW620_Human0.86868372
122SOX9_26525672_Chip-Seq_HEART_Mouse0.85067018
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84602733
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82700366
125JUN_21703547_ChIP-Seq_K562_Human0.82025962
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81437058
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.81401757
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81330675
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81189555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.86539653
2MP0009053_abnormal_anal_canal3.41308387
3MP0008438_abnormal_cutaneous_collagen3.34681214
4MP0000566_synostosis3.27769745
5MP0003283_abnormal_digestive_organ3.08605857
6MP0005503_abnormal_tendon_morphology2.97006666
7MP0002282_abnormal_trachea_morphology2.88483971
8MP0003941_abnormal_skin_development2.78895741
9MP0005275_abnormal_skin_tensile2.78794053
10MP0009250_abnormal_appendicular_skeleto2.41939036
11MP0003705_abnormal_hypodermis_morpholog2.22468907
12MP0002234_abnormal_pharynx_morphology2.17035397
13MP0005623_abnormal_meninges_morphology2.07577543
14MP0000049_abnormal_middle_ear2.05230009
15MP0000537_abnormal_urethra_morphology2.03056417
16MP0003942_abnormal_urinary_system2.01571277
17MP0003385_abnormal_body_wall1.99691294
18MP0000762_abnormal_tongue_morphology1.96872514
19MP0003755_abnormal_palate_morphology1.93662485
20MP0006292_abnormal_olfactory_placode1.91367004
21MP0005508_abnormal_skeleton_morphology1.91010490
22MP0002102_abnormal_ear_morphology1.90766658
23MP0002249_abnormal_larynx_morphology1.90391941
24MP0004272_abnormal_basement_membrane1.86825683
25MP0009384_cardiac_valve_regurgitation1.77087552
26MP0003937_abnormal_limbs/digits/tail_de1.71924711
27MP0003122_maternal_imprinting1.69785388
28MP0000383_abnormal_hair_follicle1.64124324
29MP0001346_abnormal_lacrimal_gland1.62279129
30MP0003136_yellow_coat_color1.62149561
31MP0004858_abnormal_nervous_system1.60156839
32MP0002233_abnormal_nose_morphology1.55912905
33MP0001299_abnormal_eye_distance/1.52421886
34MP0002060_abnormal_skin_morphology1.50899387
35MP0000467_abnormal_esophagus_morphology1.50243514
36MP0005248_abnormal_Harderian_gland1.47985611
37MP0002932_abnormal_joint_morphology1.47153549
38MP0003938_abnormal_ear_development1.46715628
39MP0003279_aneurysm1.45332443
40MP0000163_abnormal_cartilage_morphology1.42149003
41MP0000534_abnormal_ureter_morphology1.41049838
42MP0001849_ear_inflammation1.40162972
43MP0000428_abnormal_craniofacial_morphol1.39761642
44MP0002116_abnormal_craniofacial_bone1.39439384
45MP0009379_abnormal_foot_pigmentation1.39300815
46MP0005171_absent_coat_pigmentation1.37514310
47MP0002938_white_spotting1.33344530
48MP0003115_abnormal_respiratory_system1.32744961
49MP0005197_abnormal_uvea_morphology1.32293068
50MP0005257_abnormal_intraocular_pressure1.30472094
51MP0003315_abnormal_perineum_morphology1.28361571
52MP0002751_abnormal_autonomic_nervous1.27428222
53MP0002109_abnormal_limb_morphology1.26931213
54MP0002177_abnormal_outer_ear1.26100295
55MP0002111_abnormal_tail_morphology1.23968985
56MP0010678_abnormal_skin_adnexa1.22935420
57MP0001958_emphysema1.21446790
58MP0002115_abnormal_skeleton_extremities1.20748611
59MP0008789_abnormal_olfactory_epithelium1.19742606
60MP0003123_paternal_imprinting1.16444034
61MP0000432_abnormal_head_morphology1.16347604
62MP0003566_abnormal_cell_adhesion1.15227670
63MP0003119_abnormal_digestive_system1.14199873
64MP0002796_impaired_skin_barrier1.14035629
65MP0002098_abnormal_vibrissa_morphology1.13688088
66MP0003935_abnormal_craniofacial_develop1.12962233
67MP0002084_abnormal_developmental_patter1.12270684
68MP0004134_abnormal_chest_morphology1.10260507
69MP0003121_genomic_imprinting1.09358348
70MP0001340_abnormal_eyelid_morphology1.08847401
71MP0005367_renal/urinary_system_phenotyp1.08845978
72MP0000516_abnormal_urinary_system1.08845978
73MP0000462_abnormal_digestive_system1.06877301
74MP0000579_abnormal_nail_morphology1.06223252
75MP0000778_abnormal_nervous_system1.05120909
76MP0001286_abnormal_eye_development1.05108636
77* MP0003861_abnormal_nervous_system1.04360321
78MP0005023_abnormal_wound_healing1.03830634
79MP0002085_abnormal_embryonic_tissue1.03744051
80MP0009780_abnormal_chondrocyte_physiolo1.03583017
81MP0002113_abnormal_skeleton_development1.02790340
82MP0005499_abnormal_olfactory_system1.02020005
83MP0005394_taste/olfaction_phenotype1.02020005
84MP0001188_hyperpigmentation1.01424050
85* MP0003091_abnormal_cell_migration1.01080516
86MP0002896_abnormal_bone_mineralization0.99091681
87MP0001243_abnormal_dermal_layer0.98989501
88MP0002697_abnormal_eye_size0.98111136
89MP0000647_abnormal_sebaceous_gland0.96815070
90MP0002114_abnormal_axial_skeleton0.96508682
91MP0010771_integument_phenotype0.95264300
92MP0002108_abnormal_muscle_morphology0.94108331
93MP0001293_anophthalmia0.94065101
94MP0004133_heterotaxia0.92300278
95MP0005390_skeleton_phenotype0.91855506
96MP0003453_abnormal_keratinocyte_physiol0.91624655
97MP0002089_abnormal_postnatal_growth/wei0.90671517
98MP0010352_gastrointestinal_tract_polyps0.88907693
99MP0001177_atelectasis0.88675657
100MP0000026_abnormal_inner_ear0.86382172
101MP0002295_abnormal_pulmonary_circulatio0.86052893
102MP0006054_spinal_hemorrhage0.84976639
103MP0001542_abnormal_bone_strength0.83728958
104MP0000733_abnormal_muscle_development0.82465619
105MP0003890_abnormal_embryonic-extraembry0.81956902
106MP0002092_abnormal_eye_morphology0.80943354
107MP0000569_abnormal_digit_pigmentation0.80918252
108MP0008004_abnormal_stomach_pH0.80556597
109MP0002653_abnormal_ependyma_morphology0.80091730
110MP0005501_abnormal_skin_physiology0.79748413
111MP0008007_abnormal_cellular_replicative0.77309644
112MP0003936_abnormal_reproductive_system0.76937625
113MP0009672_abnormal_birth_weight0.76342878
114MP0002081_perinatal_lethality0.75952647
115MP0003880_abnormal_central_pattern0.75663680
116MP0001216_abnormal_epidermal_layer0.75487408
117MP0000627_abnormal_mammary_gland0.74084181
118MP0002254_reproductive_system_inflammat0.73399518
119MP0002877_abnormal_melanocyte_morpholog0.72663414
120MP0003878_abnormal_ear_physiology0.72007828
121MP0005377_hearing/vestibular/ear_phenot0.72007828
122MP0005391_vision/eye_phenotype0.70640606
123MP0000750_abnormal_muscle_regeneration0.70528052
124MP0000631_abnormal_neuroendocrine_gland0.69940445
125MP0005409_darkened_coat_color0.69889129
126MP0008932_abnormal_embryonic_tissue0.69770507
127MP0000767_abnormal_smooth_muscle0.69363240

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.65599129
2Protrusio acetabuli (HP:0003179)4.42951681
3Neonatal short-limb short stature (HP:0008921)4.03571449
4Broad metatarsal (HP:0001783)3.75763683
5Shallow orbits (HP:0000586)3.15858494
6Partial duplication of thumb phalanx (HP:0009944)3.15167220
7Atrophic scars (HP:0001075)3.07939659
8Ulnar bowing (HP:0003031)2.95367608
9Soft skin (HP:0000977)2.95188128
10Mesomelia (HP:0003027)2.85860446
11Epiphyseal dysplasia (HP:0002656)2.83913695
12Abnormality of dentin (HP:0010299)2.76744273
13Split foot (HP:0001839)2.73783670
14Vitreoretinal degeneration (HP:0000655)2.71923736
15Short middle phalanx of the 5th finger (HP:0004220)2.70331476
16Coronal craniosynostosis (HP:0004440)2.68260153
17Aplasia involving bones of the upper limbs (HP:0009823)2.61364427
18Aplasia of the phalanges of the hand (HP:0009802)2.61364427
19Aplasia involving bones of the extremities (HP:0009825)2.61364427
20Fragile skin (HP:0001030)2.60566008
21Turricephaly (HP:0000262)2.57228537
22Ankle contracture (HP:0006466)2.53080331
23Morphological abnormality of the middle ear (HP:0008609)2.51920244
24Abnormality of the distal phalanx of the thumb (HP:0009617)2.49132905
25Broad distal phalanx of finger (HP:0009836)2.45014670
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44817280
27Cutaneous finger syndactyly (HP:0010554)2.41263421
28Aortic dissection (HP:0002647)2.40824861
29Concave nail (HP:0001598)2.39768861
30Natal tooth (HP:0000695)2.38800235
31Fragile nails (HP:0001808)2.37922897
32Cervical subluxation (HP:0003308)2.37883671
33Septo-optic dysplasia (HP:0100842)2.37402985
34Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.36079261
35Abnormality of the 2nd finger (HP:0004100)2.35366565
36Abnormality of the phalanges of the 5th finger (HP:0004213)2.35313478
37Trigonocephaly (HP:0000243)2.32815840
38Down-sloping shoulders (HP:0200021)2.31873118
39Irregular epiphyses (HP:0010582)2.31068538
40Bilateral microphthalmos (HP:0007633)2.29991860
41Cutaneous syndactyly (HP:0012725)2.29633926
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26358608
43Mild short stature (HP:0003502)2.26323311
44Overgrowth (HP:0001548)2.24995574
45Short nail (HP:0001799)2.23358671
46Buphthalmos (HP:0000557)2.22678462
47Spinal cord compression (HP:0002176)2.18838057
48Cupped ribs (HP:0000887)2.18073666
49Wormian bones (HP:0002645)2.17592005
50Spinal cord lesions (HP:0100561)2.14793003
51Syringomyelia (HP:0003396)2.14793003
52Dilatation of the ascending aorta (HP:0005111)2.14513875
53Follicular hyperkeratosis (HP:0007502)2.14471458
54Vertebral compression fractures (HP:0002953)2.12615763
55Short hallux (HP:0010109)2.12042585
56Absent frontal sinuses (HP:0002688)2.11887541
57Broad long bones (HP:0005622)2.09849102
58Broad hallux (HP:0010055)2.08686325
59Biconcave vertebral bodies (HP:0004586)2.06362798
60Abnormality of the proximal phalanges of the hand (HP:0009834)2.06265440
61Abnormality of the nasal septum (HP:0000419)2.05733746
62Esophageal atresia (HP:0002032)2.05254555
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04571864
64Hypoplastic ischia (HP:0003175)2.03974714
65Thin ribs (HP:0000883)2.03263492
66Vascular tortuosity (HP:0004948)2.02193422
67Anophthalmia (HP:0000528)2.01290159
68Congenital glaucoma (HP:0001087)2.01250363
69Stenosis of the external auditory canal (HP:0000402)2.01246053
70Duplication of thumb phalanx (HP:0009942)2.00939950
71Microglossia (HP:0000171)2.00431231
72Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99817880
73Tracheomalacia (HP:0002779)1.98242436
74Spinal rigidity (HP:0003306)1.97627944
75Genu recurvatum (HP:0002816)1.96983968
76Blue sclerae (HP:0000592)1.96488154
77Aortic aneurysm (HP:0004942)1.95452444
78Synostosis of carpal bones (HP:0005048)1.94953235
79Aplasia/Hypoplasia of the hallux (HP:0008362)1.94180385
80Milia (HP:0001056)1.94066463
81Flat capital femoral epiphysis (HP:0003370)1.94009211
82Short 5th finger (HP:0009237)1.94008792
83Broad phalanx (HP:0006009)1.93832838
84Broad thumb (HP:0011304)1.93180019
85High anterior hairline (HP:0009890)1.92358125
86Peritonitis (HP:0002586)1.91781138
87Osteoarthritis (HP:0002758)1.91622714
88Short 4th metacarpal (HP:0010044)1.91275429
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91275429
90Glossoptosis (HP:0000162)1.90019439
91Limited elbow extension (HP:0001377)1.88518261
92Myelomeningocele (HP:0002475)1.88013574
93Wide anterior fontanel (HP:0000260)1.87214632
94Abnormality of the distal phalanges of the toes (HP:0010182)1.87059338
95Abnormality of the middle phalanges of the hand (HP:0009833)1.86547560
96Absent septum pellucidum (HP:0001331)1.86161201
97Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86047003
98Preaxial foot polydactyly (HP:0001841)1.86038255
99Choanal stenosis (HP:0000452)1.85768560
100Carpal synostosis (HP:0009702)1.84482074
101Arterial tortuosity (HP:0005116)1.83029093
102Abnormality of incisor morphology (HP:0011063)1.82989412
103Bowing of the arm (HP:0006488)1.82603726
104Bowed forearm bones (HP:0003956)1.82603726
105Broad toe (HP:0001837)1.82442642
106Broad phalanges of the hand (HP:0009768)1.82268799
107Synostosis involving the elbow (HP:0003938)1.82232578
108Humeroradial synostosis (HP:0003041)1.82232578
109Abnormality of molar (HP:0011077)1.81801030
110Abnormality of molar morphology (HP:0011070)1.81801030
111Renal dysplasia (HP:0000110)1.81744739
112Abnormality of the 4th metacarpal (HP:0010012)1.81359177
113Narrow nasal bridge (HP:0000446)1.79839545
114Congenital, generalized hypertrichosis (HP:0004540)1.78841703
115Abnormality of the dental root (HP:0006486)1.78572855
116Taurodontia (HP:0000679)1.78572855
117Abnormality of permanent molar morphology (HP:0011071)1.78572855
118Mixed hearing impairment (HP:0000410)1.78405115
119Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.78068152
120Pterygium (HP:0001059)1.77623116
121Arnold-Chiari malformation (HP:0002308)1.77389609
122Abnormal vertebral ossification (HP:0100569)1.77277716
123Hypoplastic labia majora (HP:0000059)1.77198343
124Overriding aorta (HP:0002623)1.77150240
125Bell-shaped thorax (HP:0001591)1.77102895
126Broad finger (HP:0001500)1.75622865
127Abnormality of the middle phalanges of the toes (HP:0010183)1.75107195
128Bronchomalacia (HP:0002780)1.73719626
129Abnormal number of incisors (HP:0011064)1.73665208
130Coxa vara (HP:0002812)1.73624844
131Abnormality of the parietal bone (HP:0002696)1.72519082
132Deviation of the hallux (HP:0010051)1.72449150
133Joint laxity (HP:0001388)1.71677164
134Flattened epiphyses (HP:0003071)1.70785571
135Increased connective tissue (HP:0009025)1.69434941
136Oligodactyly (HP:0012165)1.69204245
137Distal lower limb amyotrophy (HP:0008944)1.68339398
138Abnormality of the incisor (HP:0000676)1.67980601
139Bladder diverticulum (HP:0000015)1.67186775
140Aplasia/Hypoplasia of the fibula (HP:0006492)1.65713313
141Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64661433
142Abnormality of the ischium (HP:0003174)1.64318609
143Short middle phalanx of finger (HP:0005819)1.64233700
144Abnormality of the phalanges of the hallux (HP:0010057)1.63657170
145Partial duplication of the phalanx of hand (HP:0009999)1.62746361
146Elbow flexion contracture (HP:0002987)1.61458945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.00681204
2DDR23.98209891
3LATS23.26786595
4ERBB33.26601682
5LATS12.89410951
6KSR12.82202728
7NTRK12.78113973
8BCR2.49921918
9CASK2.40831966
10MAP3K102.38526686
11PLK22.36266790
12MKNK12.26082652
13SIK32.20250439
14PNCK1.88264334
15FER1.86047615
16TRIB31.85728797
17STK38L1.84559451
18MKNK21.72685441
19MOS1.71811831
20EPHA21.70611074
21VRK21.57331430
22MST1R1.47921768
23FLT31.45593225
24EIF2AK21.41785608
25PIM21.39791577
26TYRO31.38008448
27TRPM71.37066525
28EPHA31.34444636
29FGFR11.28553250
30PAK21.28111276
31BMX1.27675252
32TTN1.25481275
33PDGFRA1.23921197
34SIK11.23773995
35CDK81.22056214
36PKN21.16444394
37CDC71.14511978
38PLK31.14132169
39ROCK11.13707816
40MYLK1.13246437
41MAP3K31.12476923
42MINK11.12013331
43SRPK11.10684591
44MAP3K121.10285054
45TESK11.07200592
46RPS6KA41.07006437
47MAPK151.06446442
48BMPR21.06067169
49LIMK11.03875248
50RIPK11.01537350
51EPHA40.98479249
52PBK0.98219929
53ZAK0.97480632
54BUB10.96062671
55ERBB20.94038526
56TTK0.92785795
57PTK60.92154404
58TAOK20.89754818
59FGFR20.89255899
60CDK180.89062758
61MET0.87681041
62STK30.86803189
63PTK20.84911070
64NTRK30.83942295
65CDK140.83900108
66PAK40.83561832
67TAF10.83494585
68DMPK0.81884843
69ROCK20.80830292
70SMG10.79940962
71MTOR0.78788480
72BRSK20.78371326
73PAK30.77203154
74STK240.76866275
75PAK60.75912239
76TLK10.75147956
77YES10.74658723
78CDK150.74458924
79NEK20.73671936
80MST40.71125484
81PDGFRB0.69353568
82ADRBK10.68323888
83TGFBR10.68045153
84ICK0.67512612
85CAMK1G0.64879373
86CDK11A0.64832351
87CDK190.64325381
88FRK0.63849066
89EIF2AK10.63086345
90BRD40.61788971
91NEK60.60400183
92NEK90.59212145
93PLK10.58739220
94CDK70.58526224
95RPS6KA20.57595477
96MELK0.57290104
97WEE10.56669330
98AURKA0.55042089
99AURKB0.54599303
100MAP3K60.53370481
101TNIK0.50963640
102LMTK20.49861060
103MUSK0.49318206
104PRKD30.48362946
105CDK120.48134229
106RPS6KC10.47835543
107RPS6KL10.47835543
108TRIM280.47834505
109NUAK10.47585689
110NTRK20.46151677
111WNK30.45445538
112PRKG20.44394417
113CHEK20.43738229
114DYRK1B0.43652723
115DYRK1A0.43075295
116PAK10.42285091
117MAP2K10.42232584
118INSR0.42153610
119PRKD20.41915109
120MAP2K40.41848195
121AKT30.40170066
122PASK0.39048797
123ILK0.38293826
124MARK10.37960915
125PRKCE0.36944351
126NME10.35948677
127AKT20.35872393
128RPS6KA60.34884651
129CAMK2A0.32730461
130RPS6KB20.32276803
131CDK90.32208181
132RIPK40.32013004
133SRC0.31803958
134NME20.31731466
135MAPKAPK20.31708447
136DYRK30.31090100
137AKT10.30485731
138PRKCG0.29696350
139LRRK20.28836334
140DYRK20.28670585
141CHUK0.28507580
142MAP3K110.28055300
143EIF2AK30.27411332
144BRSK10.26081070
145ERBB40.26019944

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.62721955
2Hedgehog signaling pathway_Homo sapiens_hsa043402.99083150
3Hippo signaling pathway_Homo sapiens_hsa043902.74308308
4ECM-receptor interaction_Homo sapiens_hsa045122.70088105
5Proteoglycans in cancer_Homo sapiens_hsa052051.98487752
6TGF-beta signaling pathway_Homo sapiens_hsa043501.97381102
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95883758
8Wnt signaling pathway_Homo sapiens_hsa043101.91962854
9Melanogenesis_Homo sapiens_hsa049161.91749730
10Axon guidance_Homo sapiens_hsa043601.81338830
11Ribosome_Homo sapiens_hsa030101.78699573
12MicroRNAs in cancer_Homo sapiens_hsa052061.75050532
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74874722
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68151156
15Focal adhesion_Homo sapiens_hsa045101.63324859
16Bladder cancer_Homo sapiens_hsa052191.62269313
17Adherens junction_Homo sapiens_hsa045201.55969028
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48380843
19p53 signaling pathway_Homo sapiens_hsa041151.47576468
20Melanoma_Homo sapiens_hsa052181.39746738
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39176161
22Protein export_Homo sapiens_hsa030601.37235433
23Protein digestion and absorption_Homo sapiens_hsa049741.36991917
24Small cell lung cancer_Homo sapiens_hsa052221.19599217
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17039236
26Cell cycle_Homo sapiens_hsa041101.15794016
27HTLV-I infection_Homo sapiens_hsa051661.12850111
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12710144
29Pathways in cancer_Homo sapiens_hsa052001.12495188
30Gap junction_Homo sapiens_hsa045401.12195284
31Tight junction_Homo sapiens_hsa045301.09661086
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07213209
33Vibrio cholerae infection_Homo sapiens_hsa051101.05379986
34Glioma_Homo sapiens_hsa052141.02226603
35N-Glycan biosynthesis_Homo sapiens_hsa005101.01664967
36Long-term depression_Homo sapiens_hsa047300.98169498
37Rap1 signaling pathway_Homo sapiens_hsa040150.97949486
38Amoebiasis_Homo sapiens_hsa051460.97612357
39Spliceosome_Homo sapiens_hsa030400.97307383
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96524714
41Dilated cardiomyopathy_Homo sapiens_hsa054140.96055321
42Nicotine addiction_Homo sapiens_hsa050330.93906912
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92603230
44Steroid biosynthesis_Homo sapiens_hsa001000.91338393
45Prostate cancer_Homo sapiens_hsa052150.90965100
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89933938
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88645577
48Notch signaling pathway_Homo sapiens_hsa043300.87483835
49Serotonergic synapse_Homo sapiens_hsa047260.85656665
50ErbB signaling pathway_Homo sapiens_hsa040120.85642221
51Thyroid cancer_Homo sapiens_hsa052160.85262597
52RNA transport_Homo sapiens_hsa030130.84376163
53Malaria_Homo sapiens_hsa051440.82875221
54Colorectal cancer_Homo sapiens_hsa052100.82033744
55Olfactory transduction_Homo sapiens_hsa047400.81839746
56Cocaine addiction_Homo sapiens_hsa050300.80763874
57Synaptic vesicle cycle_Homo sapiens_hsa047210.80390051
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79725660
59GnRH signaling pathway_Homo sapiens_hsa049120.77065903
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75467326
61Amphetamine addiction_Homo sapiens_hsa050310.72640201
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71962246
63Phagosome_Homo sapiens_hsa041450.71786685
64Oocyte meiosis_Homo sapiens_hsa041140.70892257
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70607717
66Phototransduction_Homo sapiens_hsa047440.70137126
67Ras signaling pathway_Homo sapiens_hsa040140.68611381
68Endometrial cancer_Homo sapiens_hsa052130.68412147
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67039152
70mRNA surveillance pathway_Homo sapiens_hsa030150.65050287
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64892446
72Dopaminergic synapse_Homo sapiens_hsa047280.64473839
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.63139893
74TNF signaling pathway_Homo sapiens_hsa046680.62845015
75Circadian entrainment_Homo sapiens_hsa047130.61403460
76HIF-1 signaling pathway_Homo sapiens_hsa040660.60793094
77Chronic myeloid leukemia_Homo sapiens_hsa052200.60681073
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59968226
79Fanconi anemia pathway_Homo sapiens_hsa034600.58733454
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56974494
81Alcoholism_Homo sapiens_hsa050340.55954976
82Salivary secretion_Homo sapiens_hsa049700.55742773
83Cardiac muscle contraction_Homo sapiens_hsa042600.55690493
84Oxytocin signaling pathway_Homo sapiens_hsa049210.54685021
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.54054698
86Shigellosis_Homo sapiens_hsa051310.53218023
87Hepatitis B_Homo sapiens_hsa051610.52654508
88Sphingolipid metabolism_Homo sapiens_hsa006000.52242269
89Estrogen signaling pathway_Homo sapiens_hsa049150.52241703
90Renal cell carcinoma_Homo sapiens_hsa052110.52047724
91Arachidonic acid metabolism_Homo sapiens_hsa005900.51401521
92Huntingtons disease_Homo sapiens_hsa050160.50734106
93Glutamatergic synapse_Homo sapiens_hsa047240.50546620
94Pancreatic cancer_Homo sapiens_hsa052120.50486359
95Rheumatoid arthritis_Homo sapiens_hsa053230.49713621
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49702057
97Basal transcription factors_Homo sapiens_hsa030220.49142072
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48903732
99Cholinergic synapse_Homo sapiens_hsa047250.48287594
100Viral carcinogenesis_Homo sapiens_hsa052030.48285615
101Morphine addiction_Homo sapiens_hsa050320.48165454
102Thyroid hormone synthesis_Homo sapiens_hsa049180.48087725
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48017438
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48005259
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47589130
106MAPK signaling pathway_Homo sapiens_hsa040100.46844071
107Viral myocarditis_Homo sapiens_hsa054160.46483655
108VEGF signaling pathway_Homo sapiens_hsa043700.45799415
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44989926
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.44666565
111GABAergic synapse_Homo sapiens_hsa047270.44582793
112Nucleotide excision repair_Homo sapiens_hsa034200.43470594
113Folate biosynthesis_Homo sapiens_hsa007900.43136447
114Long-term potentiation_Homo sapiens_hsa047200.43088468
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36807051
116Lysine degradation_Homo sapiens_hsa003100.34947625
117Prion diseases_Homo sapiens_hsa050200.34561714
118Mismatch repair_Homo sapiens_hsa034300.33867223
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33624896
120Base excision repair_Homo sapiens_hsa034100.29580589
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29553163
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28784434
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28248507
124Glutathione metabolism_Homo sapiens_hsa004800.27356884
125Choline metabolism in cancer_Homo sapiens_hsa052310.26491671
126AMPK signaling pathway_Homo sapiens_hsa041520.25483621
127DNA replication_Homo sapiens_hsa030300.22360562
128Alzheimers disease_Homo sapiens_hsa050100.21311887
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.19862533
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19859450
131Inositol phosphate metabolism_Homo sapiens_hsa005620.18752787
132Biosynthesis of amino acids_Homo sapiens_hsa012300.15821647
133Non-homologous end-joining_Homo sapiens_hsa034500.14966069
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.14760130
135Pyrimidine metabolism_Homo sapiens_hsa002400.13783771
136Homologous recombination_Homo sapiens_hsa034400.13570601
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12801972
138Galactose metabolism_Homo sapiens_hsa000520.12435527

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