TPBGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)8.02792470
2positive regulation of catecholamine secretion (GO:0033605)6.32319069
3locomotory exploration behavior (GO:0035641)6.31504181
4exogenous drug catabolic process (GO:0042738)5.64721188
5exploration behavior (GO:0035640)5.21138483
6drug catabolic process (GO:0042737)4.89505982
7neuronal ion channel clustering (GO:0045161)4.55518075
8substrate-independent telencephalic tangential migration (GO:0021826)4.52808435
9substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.52808435
10sodium ion export (GO:0071436)4.38808682
11cell-cell junction maintenance (GO:0045217)4.37413204
12glutamate secretion (GO:0014047)4.33468649
13protein localization to synapse (GO:0035418)4.25057598
14arginine catabolic process (GO:0006527)4.15710251
15response to parathyroid hormone (GO:0071107)4.10022584
16regulation of cardioblast proliferation (GO:0003264)4.07607845
17regulation of secondary heart field cardioblast proliferation (GO:0003266)4.07607845
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00477970
19behavioral response to nicotine (GO:0035095)3.97784493
20melanin biosynthetic process (GO:0042438)3.90413256
21glycogen catabolic process (GO:0005980)3.86435564
22sarcoplasmic reticulum calcium ion transport (GO:0070296)3.83972225
23regulation of synaptic vesicle transport (GO:1902803)3.81589565
24tachykinin receptor signaling pathway (GO:0007217)3.75746686
25mitochondrion transport along microtubule (GO:0047497)3.69544159
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.69544159
27cellular response to pH (GO:0071467)3.66862826
28positive regulation of neurotransmitter transport (GO:0051590)3.65508609
29glucan catabolic process (GO:0009251)3.61888952
30regulation of skeletal muscle contraction (GO:0014819)3.60287655
31positive regulation of amine transport (GO:0051954)3.60016609
32potassium ion export (GO:0071435)3.57927387
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57770289
34cell migration in hindbrain (GO:0021535)3.57242964
35membrane repolarization during action potential (GO:0086011)3.53307613
36regulation of synaptic vesicle exocytosis (GO:2000300)3.52835679
37mannose metabolic process (GO:0006013)3.50486853
38cell junction maintenance (GO:0034331)3.49645603
39establishment of mitochondrion localization (GO:0051654)3.45121367
40regulation of synapse structural plasticity (GO:0051823)3.43608854
41urea metabolic process (GO:0019627)3.43123649
42urea cycle (GO:0000050)3.43123649
43relaxation of smooth muscle (GO:0044557)3.40504774
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.39334450
45negative regulation of neurotransmitter secretion (GO:0046929)3.36682399
46arginine metabolic process (GO:0006525)3.36642867
47negative regulation of microtubule polymerization (GO:0031115)3.35043297
48membrane repolarization (GO:0086009)3.34837603
49plasma membrane repair (GO:0001778)3.34070434
50cellular potassium ion homeostasis (GO:0030007)3.34044649
51synaptic transmission, dopaminergic (GO:0001963)3.33952862
52peripheral nervous system neuron development (GO:0048935)3.33913364
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.33875383
54melanin metabolic process (GO:0006582)3.32266712
55secondary metabolite biosynthetic process (GO:0044550)3.30791838
56coronary vasculature morphogenesis (GO:0060977)3.30244380
57cellular polysaccharide catabolic process (GO:0044247)3.30058828
58regulation of synaptic transmission, dopaminergic (GO:0032225)3.29582342
59carnitine shuttle (GO:0006853)3.27762409
60response to muscle activity (GO:0014850)3.26664181
61receptor recycling (GO:0001881)3.26193441
62membrane depolarization during action potential (GO:0086010)3.24164658
63pyrimidine nucleobase catabolic process (GO:0006208)3.24012300
64regulation of catecholamine secretion (GO:0050433)3.23368592
65enteric nervous system development (GO:0048484)3.22164147
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.21251294
67L-phenylalanine catabolic process (GO:0006559)3.21251294
68negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.19596925
69regulation of autophagic vacuole assembly (GO:2000785)3.19591183
70cerebellar Purkinje cell differentiation (GO:0021702)3.18320401
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.18275715
72nitrogen cycle metabolic process (GO:0071941)3.16944839
73detection of light stimulus involved in visual perception (GO:0050908)3.15482592
74detection of light stimulus involved in sensory perception (GO:0050962)3.15482592
75fatty acid transmembrane transport (GO:1902001)3.14728750
76regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.14586778
77L-phenylalanine metabolic process (GO:0006558)3.14579949
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14579949
79neurofilament cytoskeleton organization (GO:0060052)3.11158357
80skeletal muscle contraction (GO:0003009)3.10941215
81innervation (GO:0060384)3.10604841
82regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.10487799
83regulation of circadian sleep/wake cycle (GO:0042749)3.10487799
84regulation of dopamine secretion (GO:0014059)3.09978213
85muscle filament sliding (GO:0030049)3.08547149
86actin-myosin filament sliding (GO:0033275)3.08547149
87dopamine receptor signaling pathway (GO:0007212)3.08310222
88neuromuscular process controlling posture (GO:0050884)3.08026325
89presynaptic membrane organization (GO:0097090)3.07397468
90positive regulation of neurotransmitter secretion (GO:0001956)3.07310233
91polysaccharide catabolic process (GO:0000272)3.06223561
92neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.05940941
93cell communication by electrical coupling (GO:0010644)3.05048867
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.04812475
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02555298
96regulation of cholesterol homeostasis (GO:2000188)3.01547721
97positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01280408
98regulation of glutamate receptor signaling pathway (GO:1900449)3.00720676
99calcium ion-dependent exocytosis (GO:0017156)3.00228877
100multicellular organism reproduction (GO:0032504)2.98495593
101negative regulation of appetite (GO:0032099)2.98041413
102negative regulation of response to food (GO:0032096)2.98041413
103forebrain neuron differentiation (GO:0021879)2.95449634
104detection of temperature stimulus (GO:0016048)2.95160629
105neuron recognition (GO:0008038)2.92622914
1064-hydroxyproline metabolic process (GO:0019471)2.92163220
107positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92000650
108regulation of receptor binding (GO:1900120)2.91379046
109regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.90049981
110regulation of neurotransmitter secretion (GO:0046928)2.89799412
111alpha-linolenic acid metabolic process (GO:0036109)2.88694711
112pyrimidine ribonucleoside catabolic process (GO:0046133)2.86718144
113respiratory system process (GO:0003016)2.86618123
114uterus development (GO:0060065)2.85973531
115regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84916240
116negative regulation of macrophage differentiation (GO:0045650)2.84397725
117ganglion development (GO:0061548)2.84339735
118adhesion of symbiont to host cell (GO:0044650)2.84323288
119virion attachment to host cell (GO:0019062)2.84323288
120synaptic vesicle maturation (GO:0016188)2.84008631
121glycolytic process (GO:0006096)2.83427950
122axon extension (GO:0048675)2.83194513
123cellular sodium ion homeostasis (GO:0006883)2.80772522
124regulation of neuronal synaptic plasticity (GO:0048168)2.78904842
125skeletal muscle adaptation (GO:0043501)2.77287394
126response to gravity (GO:0009629)2.76221050
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75944069
128negative regulation of calcium ion transport into cytosol (GO:0010523)2.75872148
129response to pH (GO:0009268)2.75797350
130regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73728326
131axonal fasciculation (GO:0007413)2.73114128
132regulation of fatty acid beta-oxidation (GO:0031998)2.72737502
133regulation of gonadotropin secretion (GO:0032276)2.72542305
134circadian sleep/wake cycle process (GO:0022410)2.72083660
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71947140
136high-density lipoprotein particle remodeling (GO:0034375)2.71626426
137response to acidic pH (GO:0010447)2.71092556
138protein carboxylation (GO:0018214)2.71009887
139peptidyl-glutamic acid carboxylation (GO:0017187)2.71009887
140mesenchymal to epithelial transition (GO:0060231)2.70860537
141dicarboxylic acid biosynthetic process (GO:0043650)2.69728514
142short-term memory (GO:0007614)2.69635175
143regulation of vacuole organization (GO:0044088)2.69492370
144suckling behavior (GO:0001967)2.68777562
145alanine transport (GO:0032328)2.68605734
146neuromuscular synaptic transmission (GO:0007274)2.68587311
147negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68248788
148sexual reproduction (GO:0019953)2.67587818
149fructose metabolic process (GO:0006000)2.66929289
150positive regulation of gastrulation (GO:2000543)2.66349488
151regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65107327
152protein hydroxylation (GO:0018126)2.64932248
153pyruvate metabolic process (GO:0006090)2.64849992
154adult walking behavior (GO:0007628)2.64653646
155negative regulation of metanephros development (GO:0072217)2.64412008
156dendritic spine morphogenesis (GO:0060997)2.62966963
157neuronal action potential propagation (GO:0019227)2.61824381
158striated muscle contraction (GO:0006941)2.61349988
159reverse cholesterol transport (GO:0043691)2.61033843
160body morphogenesis (GO:0010171)2.61025767
161positive regulation of sodium ion transmembrane transport (GO:1902307)2.60525143
162protein polyglutamylation (GO:0018095)2.60469223
163aromatic amino acid family catabolic process (GO:0009074)2.60029624
164response to mercury ion (GO:0046689)2.59145185
165fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58825644
166lysine catabolic process (GO:0006554)2.58126201
167lysine metabolic process (GO:0006553)2.58126201
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.58086435
169potassium ion homeostasis (GO:0055075)2.58031842
170kynurenine metabolic process (GO:0070189)2.56443176
171negative regulation of macroautophagy (GO:0016242)2.56119269
172negative regulation of response to extracellular stimulus (GO:0032105)2.56115431
173negative regulation of response to nutrient levels (GO:0032108)2.56115431
174hypothalamus development (GO:0021854)2.55467232
175axon regeneration (GO:0031103)2.55243416
176regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53672472
177negative regulation of catecholamine secretion (GO:0033604)2.53538834
178myoblast fusion (GO:0007520)2.50190566
179phospholipid efflux (GO:0033700)2.49912133
180detection of temperature stimulus involved in sensory perception (GO:0050961)2.48535233
181detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.48535233
182iron coordination entity transport (GO:1901678)2.46974052
183carnitine transmembrane transport (GO:1902603)2.46532986
184creatine metabolic process (GO:0006600)2.45707966
185positive regulation of lipid catabolic process (GO:0050996)2.45486735
186synaptic vesicle exocytosis (GO:0016079)2.44667392
187pyrimidine nucleoside catabolic process (GO:0046135)2.44658745
1882-oxoglutarate metabolic process (GO:0006103)2.44182888
189bile acid biosynthetic process (GO:0006699)2.43058023
190actin-mediated cell contraction (GO:0070252)2.41925851
191gluconeogenesis (GO:0006094)2.41849289
192positive regulation of fatty acid oxidation (GO:0046321)2.41787805
193cholesterol efflux (GO:0033344)2.41704447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47316285
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.26663586
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95987975
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.50788901
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.06516670
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.87757676
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70583211
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.68673998
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.41801825
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32082651
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26267364
12DROSHA_22980978_ChIP-Seq_HELA_Human2.03932811
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95862727
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.95145721
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88837593
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86336123
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85488308
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82874975
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82392682
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81626681
21ZNF263_19887448_ChIP-Seq_K562_Human1.81347938
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79040259
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79040259
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78738665
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77829780
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71269389
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66728418
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65332122
29LXR_22292898_ChIP-Seq_THP-1_Human1.60831922
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58191830
31CTCF_27219007_Chip-Seq_Bcells_Human1.57679339
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.57354920
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.54238395
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51587132
35REST_21632747_ChIP-Seq_MESCs_Mouse1.50659236
36KDM2B_26808549_Chip-Seq_K562_Human1.50247650
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49519853
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.47231210
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47214010
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.46833049
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.45777062
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43606956
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.43315747
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41863417
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41726410
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38794633
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36099163
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.34703186
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34667994
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.31901294
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29341739
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28118287
53CLOCK_20551151_ChIP-Seq_293T_Human1.27633272
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25597010
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25038796
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22238302
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20939474
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20508223
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18933962
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.18760275
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18578598
62GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.17993027
63OCT4_19829295_ChIP-Seq_ESCs_Human1.16992412
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.13621280
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13580549
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12436489
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12295931
68KDM2B_26808549_Chip-Seq_DND41_Human1.12147675
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11035074
70CTCF_20526341_ChIP-Seq_ESCs_Human1.08459979
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08399310
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07090912
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06618658
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.06175001
75AR_21572438_ChIP-Seq_LNCaP_Human1.05803570
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05004462
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.02796027
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01180009
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00999600
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00933624
81EGR1_19032775_ChIP-ChIP_M12_Human1.00140475
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.00087492
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99855419
84TBX20_22328084_ChIP-Seq_HEART_Mouse0.99403743
85TBX20_22080862_ChIP-Seq_HEART_Mouse0.99403743
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.98759515
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.97785074
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97002331
89ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96808701
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96605538
91GBX2_23144817_ChIP-Seq_PC3_Human0.96141912
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.95348457
93PHF8_20622854_ChIP-Seq_HELA_Human0.93042655
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92575392
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91922869
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.91316644
97RNF2_27304074_Chip-Seq_NSC_Mouse0.90930903
98RACK7_27058665_Chip-Seq_MCF-7_Human0.90925261
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90553606
100CREB1_26743006_Chip-Seq_LNCaP_Human0.89426459
101FOXA2_19822575_ChIP-Seq_HepG2_Human0.89328650
102EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89109200
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.89009005
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88454854
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87846176
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87552937
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87535889
108KLF4_19829295_ChIP-Seq_ESCs_Human0.87265345
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85993154
110BCOR_27268052_Chip-Seq_Bcells_Human0.85663908
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85630170
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85380529
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85130783
114MYC_27129775_Chip-Seq_CORNEA_Mouse0.84695864
115VDR_21846776_ChIP-Seq_THP-1_Human0.84193464
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84102654
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83850055
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.83555055
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.83373092
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.83367393
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83302217
122BCL6_27268052_Chip-Seq_Bcells_Human0.82811822
123E2F1_20622854_ChIP-Seq_HELA_Human0.82171128
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.82143240
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81643024
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.81086315
127STAT1_20625510_ChIP-Seq_HELA_Human0.80672666
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80463811
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80455382
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80455382
131SMC4_20622854_ChIP-Seq_HELA_Human0.80297699
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80022022
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79615834
134P68_20966046_ChIP-Seq_HELA_Human0.79472307
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79405757
136SA1_27219007_Chip-Seq_Bcells_Human0.78864996
137TP63_22573176_ChIP-Seq_HFKS_Human0.78416594
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78381277
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.77516397
140OCT4_20526341_ChIP-Seq_ESCs_Human0.77160883
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.76609099
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76146307
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76116926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting6.35913306
2MP0003646_muscle_fatigue4.22623150
3MP0004145_abnormal_muscle_electrophysio3.84976665
4MP0004858_abnormal_nervous_system3.84734906
5MP0003787_abnormal_imprinting3.53321377
6MP0002139_abnormal_hepatobiliary_system3.31638185
7MP0004036_abnormal_muscle_relaxation3.06497493
8MP0004233_abnormal_muscle_weight2.96228217
9MP0000749_muscle_degeneration2.95210044
10MP0003880_abnormal_central_pattern2.93579175
11MP0005360_urolithiasis2.91681618
12MP0000751_myopathy2.85928905
13MP0005085_abnormal_gallbladder_physiolo2.80090683
14MP0005423_abnormal_somatic_nervous2.73075153
15MP0005083_abnormal_biliary_tract2.53602903
16MP0009840_abnormal_foam_cell2.44762984
17MP0004084_abnormal_cardiac_muscle2.44245513
18MP0005365_abnormal_bile_salt2.42502942
19MP0000747_muscle_weakness2.37541617
20MP0003315_abnormal_perineum_morphology2.35801168
21MP0002269_muscular_atrophy2.24839717
22MP0004130_abnormal_muscle_cell2.22569592
23MP0002090_abnormal_vision2.22344252
24MP0006276_abnormal_autonomic_nervous2.21135703
25MP0001188_hyperpigmentation2.16561754
26MP0003172_abnormal_lysosome_physiology2.11461648
27MP0003121_genomic_imprinting2.03503294
28MP0005410_abnormal_fertilization1.94985755
29MP0003191_abnormal_cellular_cholesterol1.93578771
30MP0003045_fibrosis1.93035980
31MP0010329_abnormal_lipoprotein_level1.91700332
32MP0002653_abnormal_ependyma_morphology1.90547839
33MP0002106_abnormal_muscle_physiology1.90480308
34MP0002063_abnormal_learning/memory/cond1.89820129
35MP0009046_muscle_twitch1.82125166
36MP0000759_abnormal_skeletal_muscle1.81149689
37MP0005620_abnormal_muscle_contractility1.77495951
38MP0005551_abnormal_eye_electrophysiolog1.74810633
39MP0008875_abnormal_xenobiotic_pharmacok1.74486879
40MP0009745_abnormal_behavioral_response1.73118913
41MP0004510_myositis1.72138760
42MP0001502_abnormal_circadian_rhythm1.70133948
43MP0005670_abnormal_white_adipose1.66417818
44MP0002572_abnormal_emotion/affect_behav1.65919616
45MP0002735_abnormal_chemical_nociception1.65365551
46MP0003329_amyloid_beta_deposits1.63317542
47MP0005409_darkened_coat_color1.63025201
48MP0002822_catalepsy1.58760875
49MP0008775_abnormal_heart_ventricle1.57705788
50MP0002163_abnormal_gland_morphology1.54114323
51MP0004087_abnormal_muscle_fiber1.51637901
52MP0010368_abnormal_lymphatic_system1.50075996
53MP0008961_abnormal_basal_metabolism1.49515279
54MP0005369_muscle_phenotype1.48399563
55MP0003252_abnormal_bile_duct1.47383335
56MP0001905_abnormal_dopamine_level1.45155032
57MP0004270_analgesia1.41975865
58MP0002882_abnormal_neuron_morphology1.41621079
59MP0000778_abnormal_nervous_system1.41298847
60MP0000343_altered_response_to1.39326641
61MP0002557_abnormal_social/conspecific_i1.38064082
62MP0002837_dystrophic_cardiac_calcinosis1.37988507
63MP0008004_abnormal_stomach_pH1.36675092
64MP0002332_abnormal_exercise_endurance1.35292537
65MP0003868_abnormal_feces_composition1.33927432
66MP0002909_abnormal_adrenal_gland1.30166454
67MP0001984_abnormal_olfaction1.30060261
68MP0003075_altered_response_to1.24388148
69MP0006072_abnormal_retinal_apoptosis1.23601144
70MP0000604_amyloidosis1.22254040
71MP0005584_abnormal_enzyme/coenzyme_acti1.21388604
72MP0010386_abnormal_urinary_bladder1.20906343
73MP0004859_abnormal_synaptic_plasticity1.19836255
74MP0000920_abnormal_myelination1.19625128
75MP0005332_abnormal_amino_acid1.19237120
76MP0002118_abnormal_lipid_homeostasis1.16911376
77MP0005394_taste/olfaction_phenotype1.16595274
78MP0005499_abnormal_olfactory_system1.16595274
79MP0005319_abnormal_enzyme/_coenzyme1.16390626
80MP0005167_abnormal_blood-brain_barrier1.15193170
81MP0002751_abnormal_autonomic_nervous1.13115731
82MP0005646_abnormal_pituitary_gland1.10087796
83MP0002736_abnormal_nociception_after1.08676479
84MP0000534_abnormal_ureter_morphology1.08117960
85MP0002638_abnormal_pupillary_reflex1.07371469
86MP0006082_CNS_inflammation1.06300757
87MP0001486_abnormal_startle_reflex1.05004328
88MP0002752_abnormal_somatic_nervous1.04204608
89MP0006138_congestive_heart_failure1.02955050
90MP0005058_abnormal_lysosome_morphology1.02585668
91MP0002089_abnormal_postnatal_growth/wei1.00770463
92MP0002229_neurodegeneration1.00600840
93MP0001968_abnormal_touch/_nociception1.00285460
94MP0003634_abnormal_glial_cell1.00046164
95MP0004134_abnormal_chest_morphology0.99641053
96MP0002184_abnormal_innervation0.99038917
97MP0005166_decreased_susceptibility_to0.97635439
98MP0008877_abnormal_DNA_methylation0.96632229
99MP0002972_abnormal_cardiac_muscle0.96445294
100MP0003631_nervous_system_phenotype0.95772126
101MP0002160_abnormal_reproductive_system0.91357230
102MP0000750_abnormal_muscle_regeneration0.90722281
103MP0002066_abnormal_motor_capabilities/c0.90246964
104MP0002733_abnormal_thermal_nociception0.89242877
105MP0003635_abnormal_synaptic_transmissio0.88534352
106MP0004883_abnormal_blood_vessel0.87782140
107MP0000955_abnormal_spinal_cord0.86733350
108MP0004185_abnormal_adipocyte_glucose0.85629317
109MP0008874_decreased_physiological_sensi0.85594704
110MP0003705_abnormal_hypodermis_morpholog0.85292016
111MP0006036_abnormal_mitochondrial_physio0.85270849
112MP0003656_abnormal_erythrocyte_physiolo0.84313508
113MP0002152_abnormal_brain_morphology0.84151860
114MP0002064_seizures0.84149084
115MP0002734_abnormal_mechanical_nocicepti0.84133745
116MP0000609_abnormal_liver_physiology0.83975543
117MP0001270_distended_abdomen0.83592122
118MP0001501_abnormal_sleep_pattern0.83476702
119MP0004811_abnormal_neuron_physiology0.82921297
120MP0004742_abnormal_vestibular_system0.81919751
121MP0002067_abnormal_sensory_capabilities0.80059575
122MP0001970_abnormal_pain_threshold0.80037541
123MP0002127_abnormal_cardiovascular_syste0.79339336
124MP0003690_abnormal_glial_cell0.78363931
125MP0000537_abnormal_urethra_morphology0.77970904
126MP0005666_abnormal_adipose_tissue0.77026577
127MP0003806_abnormal_nucleotide_metabolis0.76830954
128MP0001544_abnormal_cardiovascular_syste0.76770073
129MP0005385_cardiovascular_system_phenoty0.76770073
130MP0005257_abnormal_intraocular_pressure0.76767319
131MP0002078_abnormal_glucose_homeostasis0.76094049
132MP0003221_abnormal_cardiomyocyte_apopto0.76071809
133MP0004043_abnormal_pH_regulation0.75856479
134MP0004484_altered_response_of0.75764321
135MP0005379_endocrine/exocrine_gland_phen0.75470016
136MP0001440_abnormal_grooming_behavior0.75241614
137MP0003633_abnormal_nervous_system0.74036212
138MP0003890_abnormal_embryonic-extraembry0.73845589
139MP0002928_abnormal_bile_duct0.73131336
140MP0003879_abnormal_hair_cell0.72854017
141MP0002272_abnormal_nervous_system0.72651879
142MP0005334_abnormal_fat_pad0.72623202
143MP0008872_abnormal_physiological_respon0.71731777
144MP0008569_lethality_at_weaning0.71308736
145MP0005195_abnormal_posterior_eye0.71096037
146MP0000230_abnormal_systemic_arterial0.69611098
147MP0001986_abnormal_taste_sensitivity0.69530588
148MP0001963_abnormal_hearing_physiology0.69503840
149MP0000639_abnormal_adrenal_gland0.69311907
150MP0002971_abnormal_brown_adipose0.68067272
151MP0000538_abnormal_urinary_bladder0.63945689
152MP0005448_abnormal_energy_balance0.63677267
153MP0001919_abnormal_reproductive_system0.62643980
154MP0004885_abnormal_endolymph0.61389684
155MP0002998_abnormal_bone_remodeling0.60891425
156MP0005310_abnormal_salivary_gland0.60404268
157MP0003632_abnormal_nervous_system0.60188760
158MP0003119_abnormal_digestive_system0.59616886
159MP0001849_ear_inflammation0.56743554
160MP0005647_abnormal_sex_gland0.56650148
161MP0004924_abnormal_behavior0.56029606
162MP0005386_behavior/neurological_phenoty0.56029606

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.26670428
2Exercise-induced muscle cramps (HP:0003710)5.43539475
3Abnormality of glycolipid metabolism (HP:0010969)4.85929994
4Abnormality of liposaccharide metabolism (HP:0010968)4.85929994
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.85929994
6Muscle fiber inclusion bodies (HP:0100299)4.69600834
7Myoglobinuria (HP:0002913)4.69512669
8Distal arthrogryposis (HP:0005684)4.62848811
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.48346779
10Muscle stiffness (HP:0003552)4.37769899
11Neurofibrillary tangles (HP:0002185)4.34923282
12Pheochromocytoma (HP:0002666)4.05924059
13Nemaline bodies (HP:0003798)4.02298165
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.98722083
15Congenital stationary night blindness (HP:0007642)3.95322908
16Cholecystitis (HP:0001082)3.86334039
17Abnormal gallbladder physiology (HP:0012438)3.86334039
18Disinhibition (HP:0000734)3.81623213
19Dysostosis multiplex (HP:0000943)3.75462333
20Myopathic facies (HP:0002058)3.72159758
21Muscle hypertrophy of the lower extremities (HP:0008968)3.68601349
22Hyporeflexia of lower limbs (HP:0002600)3.65724996
23Limb dystonia (HP:0002451)3.60691650
24Neuroendocrine neoplasm (HP:0100634)3.55960733
25Round ear (HP:0100830)3.49703977
26Myotonia (HP:0002486)3.45793970
27Apathy (HP:0000741)3.40273335
28Myokymia (HP:0002411)3.40056023
29Rhabdomyolysis (HP:0003201)3.39163663
30Abnormal pancreas size (HP:0012094)3.36383845
31Inappropriate behavior (HP:0000719)3.35055658
32Difficulty running (HP:0009046)3.32783147
33Type 1 muscle fiber predominance (HP:0003803)3.30122741
34Diminished motivation (HP:0000745)3.26494538
35Calf muscle hypertrophy (HP:0008981)3.24493922
36Vacuolated lymphocytes (HP:0001922)3.18041673
37Thoracic kyphosis (HP:0002942)3.15724488
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.15389605
39Complement deficiency (HP:0004431)3.15305034
40Visual hallucinations (HP:0002367)3.15104844
41Cerebral inclusion bodies (HP:0100314)3.11985542
42Focal dystonia (HP:0004373)3.06564524
43EMG: myopathic abnormalities (HP:0003458)3.06313150
44Systemic lupus erythematosus (HP:0002725)3.06037212
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.04263785
46Absent phalangeal crease (HP:0006109)2.97219748
47Polyphagia (HP:0002591)2.96689973
48Hepatoblastoma (HP:0002884)2.94390563
49Agitation (HP:0000713)2.93911107
50Ulnar deviation of the wrist (HP:0003049)2.91185297
51Potter facies (HP:0002009)2.89442140
52Facial shape deformation (HP:0011334)2.89442140
53Asymmetric septal hypertrophy (HP:0001670)2.86758846
54Postural instability (HP:0002172)2.80425307
55Muscle fiber splitting (HP:0003555)2.77792620
56Neuronal loss in central nervous system (HP:0002529)2.76541941
57Deep venous thrombosis (HP:0002625)2.73434214
58Hypercortisolism (HP:0001578)2.72396794
59Adrenal hypoplasia (HP:0000835)2.71890142
60Axonal loss (HP:0003447)2.70309726
61Metaphyseal dysplasia (HP:0100255)2.69528941
62Torticollis (HP:0000473)2.69172180
63Abnormality of polysaccharide metabolism (HP:0011012)2.69061477
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69061477
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69061477
66Upper motor neuron abnormality (HP:0002127)2.66023951
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65559061
68Xanthomatosis (HP:0000991)2.64849548
69Impaired vibration sensation in the lower limbs (HP:0002166)2.64399410
70Cholelithiasis (HP:0001081)2.62622140
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61935245
72Central scotoma (HP:0000603)2.58445984
73Abnormal sex determination (HP:0012244)2.57592868
74Sex reversal (HP:0012245)2.57592868
75Loss of speech (HP:0002371)2.57214871
76Hypoalphalipoproteinemia (HP:0003233)2.56305213
77Cerebral hemorrhage (HP:0001342)2.55412160
78Urinary glycosaminoglycan excretion (HP:0003541)2.55005512
79Mucopolysacchariduria (HP:0008155)2.55005512
80Anosmia (HP:0000458)2.53275175
81Dementia (HP:0000726)2.49279550
82Urinary urgency (HP:0000012)2.49009246
83Craniofacial dystonia (HP:0012179)2.47843695
84Abnormality of the Achilles tendon (HP:0005109)2.42619352
85Neonatal hypoglycemia (HP:0001998)2.41463974
86Abnormal finger flexion creases (HP:0006143)2.41032513
87Thoracolumbar scoliosis (HP:0002944)2.40830061
88Ankle clonus (HP:0011448)2.40095920
89Neoplasm of the adrenal cortex (HP:0100641)2.38824605
90Abnormal gallbladder morphology (HP:0012437)2.37442538
91Increased connective tissue (HP:0009025)2.36898132
92Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33272113
93Neonatal onset (HP:0003623)2.32205496
94Urinary bladder sphincter dysfunction (HP:0002839)2.31687147
95Anomalous pulmonary venous return (HP:0010772)2.31231917
96Amblyopia (HP:0000646)2.30371329
97Ulnar claw (HP:0001178)2.30127084
98Nuclear cataract (HP:0100018)2.29728996
99Difficulty climbing stairs (HP:0003551)2.28375062
100Achilles tendon contracture (HP:0001771)2.27460746
101Agnosia (HP:0010524)2.26687100
102Diastasis recti (HP:0001540)2.26619066
103Abnormality of the calf musculature (HP:0001430)2.25012597
104Retinal atrophy (HP:0001105)2.21797597
105Action tremor (HP:0002345)2.20772822
106Hypolipoproteinemia (HP:0010981)2.20574032
107Abnormality of the thoracic spine (HP:0100711)2.18348985
108Increased variability in muscle fiber diameter (HP:0003557)2.17787186
109Progressive cerebellar ataxia (HP:0002073)2.17462964
110Striae distensae (HP:0001065)2.16538320
111Abnormality of skeletal muscle fiber size (HP:0012084)2.15585629
112EMG: neuropathic changes (HP:0003445)2.15471303
113Macroglossia (HP:0000158)2.13984887
114Neoplasm of the peripheral nervous system (HP:0100007)2.13430762
115Abnormality of the parathyroid morphology (HP:0011766)2.08650908
116Abnormal eating behavior (HP:0100738)2.07618612
117Gout (HP:0001997)2.07008415
118Intrahepatic cholestasis (HP:0001406)2.06051937
119Abnormality of complement system (HP:0005339)2.05620866
120Hypoventilation (HP:0002791)2.05423518
121Hypobetalipoproteinemia (HP:0003563)2.03654390
122Focal seizures (HP:0007359)2.03507490
123Hyperkalemia (HP:0002153)2.02421957
124Enlarged penis (HP:0000040)2.01722784
125Areflexia of lower limbs (HP:0002522)2.01409927
126Hyperthyroidism (HP:0000836)2.01138404
127Hyperlipoproteinemia (HP:0010980)1.99653576
128Epileptic encephalopathy (HP:0200134)1.98431598
129Cerebral hypomyelination (HP:0006808)1.98399616
130Turricephaly (HP:0000262)1.95527530
131Ventricular fibrillation (HP:0001663)1.95342508
132Cerebral aneurysm (HP:0004944)1.95143508
133J-shaped sella turcica (HP:0002680)1.94238343
134Febrile seizures (HP:0002373)1.93971223
135Fetal akinesia sequence (HP:0001989)1.93500567
136Abnormality of the pulmonary veins (HP:0011718)1.93363548
137Testicular neoplasm (HP:0010788)1.93122889
138Retinal dysplasia (HP:0007973)1.93055392
139Hyperammonemia (HP:0001987)1.92719243
140Mutism (HP:0002300)1.92643961
141Frequent falls (HP:0002359)1.91807036
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91625431
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91625431
144Failure to thrive in infancy (HP:0001531)1.91298756
145Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90851772
146Atonic seizures (HP:0010819)1.90647067
147Supranuclear gaze palsy (HP:0000605)1.90218284
148Ketosis (HP:0001946)1.89375083
149Clumsiness (HP:0002312)1.88884920
150Glomerulonephritis (HP:0000099)1.88687861
151Deep palmar crease (HP:0006191)1.88321517
152Sensorimotor neuropathy (HP:0007141)1.87219509
153Disproportionate tall stature (HP:0001519)1.86702578
154Peripheral hypomyelination (HP:0007182)1.86001332
155Abnormality of the lower motor neuron (HP:0002366)1.85191645
156Abnormality of macular pigmentation (HP:0008002)1.84768453
157Hand muscle atrophy (HP:0009130)1.83180448
158Resting tremor (HP:0002322)1.81987481
159Truncal ataxia (HP:0002078)1.81716578
160Spastic gait (HP:0002064)1.81707863
161Calcaneovalgus deformity (HP:0001848)1.79924680
162Intention tremor (HP:0002080)1.79540214
163Spastic tetraplegia (HP:0002510)1.79075214
164Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78841297
165Metaphyseal irregularity (HP:0003025)1.78694876
166Prolonged neonatal jaundice (HP:0006579)1.78602575
167Depression (HP:0000716)1.78471922
168Distal upper limb amyotrophy (HP:0007149)1.77707975
169Upper limb amyotrophy (HP:0009129)1.77707975
170Abnormality of binocular vision (HP:0011514)1.77661277
171Diplopia (HP:0000651)1.77661277
172Periauricular skin pits (HP:0100277)1.77367344
173Preauricular pit (HP:0004467)1.77367344
174Germ cell neoplasia (HP:0100728)1.77316326
175Foot dorsiflexor weakness (HP:0009027)1.77145027
176Bradykinesia (HP:0002067)1.75965997
177Male infertility (HP:0003251)1.74590585
178Epidermoid cyst (HP:0200040)1.74516478
179Scotoma (HP:0000575)1.73837995
180Abnormality of the gallbladder (HP:0005264)1.73740767
181Generalized tonic-clonic seizures (HP:0002069)1.73422689
182Stereotypic behavior (HP:0000733)1.73244130
183Palpitations (HP:0001962)1.72670770
184Increased cerebral lipofuscin (HP:0011813)1.72140702
185Abnormality of the aortic arch (HP:0012303)1.71864060
186Global brain atrophy (HP:0002283)1.71565158
187Rapidly progressive (HP:0003678)1.71303205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.24330338
2PHKG24.24330338
3OBSCN2.86863170
4NEK12.73785104
5MAP3K92.69950636
6MARK32.50697852
7MAP2K72.47619477
8STK162.42492776
9TTN2.23458467
10NME22.17237820
11LMTK22.13311125
12EPHA42.05932097
13SIK12.05584757
14ERN12.05180562
15MARK12.04861429
16NME12.02991142
17KSR21.97325319
18MAP3K71.90566835
19TGFBR21.90401831
20TRIB31.89978937
21MAP2K41.89136639
22TYRO31.83702508
23PKN21.82353762
24MAP2K31.81984047
25NTRK11.78152905
26RET1.72506310
27IRAK31.67471749
28PINK11.64982502
29CSNK1G21.63006943
30BCKDK1.61612925
31BRAF1.60905218
32MINK11.58982310
33MAPK121.56808431
34FLT31.53634486
35DYRK31.50405792
36MAPKAPK31.48717624
37SIK21.47797532
38PTK21.44575435
39GRK51.39075486
40PDK31.37660300
41PDK41.37660300
42RIPK11.35296357
43PAK61.34969015
44CASK1.34624117
45EEF2K1.34620808
46MARK21.34497046
47CSNK1G31.32011022
48CSNK1A1L1.31020987
49NTRK21.28115082
50DYRK21.27792130
51PIK3CG1.24625548
52MAP3K41.18226634
53NEK91.17827798
54CDK141.13628202
55NTRK31.13430202
56DDR21.12944425
57ADRBK21.12165097
58PRKCG1.10217931
59LATS21.05231878
60ABL21.04669688
61MAP2K61.01543331
62ARAF1.00968905
63ICK0.95821041
64CAMK40.94754886
65MAPK150.93504784
66MATK0.93426198
67CAMKK20.92560270
68PDK20.90265993
69STK380.88002393
70CAMK10.87503367
71RPS6KA20.87421823
72ZAP700.82717803
73ACVR1B0.81692825
74DAPK20.81603861
75DAPK30.81148155
76MOS0.80674956
77FGFR40.80042139
78CDK150.79488257
79CAMK1G0.79333842
80TAOK20.78629706
81CSNK1G10.78580411
82PRKAA10.77921777
83TAOK10.77465243
84PIM20.77289605
85CSF1R0.73938648
86MAP3K10.73540052
87DYRK1B0.73538015
88JAK10.71678266
89CDK180.71210141
90CAMKK10.70621745
91MAP3K130.70490631
92CDK11A0.69457107
93MAP2K10.69326977
94PRKAA20.68001372
95FRK0.67622774
96SGK20.62257291
97LIMK10.61607069
98CDK90.58986480
99TIE10.58608592
100PRKD30.58504952
101CDC42BPA0.58404700
102FGR0.57955682
103MAP3K20.57792484
104PDPK10.57225171
105PTK2B0.57215382
106PTK60.56984031
107PDK10.53104516
108MAPK110.52164515
109CAMK1D0.51942672
110DAPK10.51390466
111TYK20.49486589
112TNK20.49425131
113TGFBR10.49256665
114CSK0.48956254
115PRKACG0.48545024
116EPHB10.48320055
117RPS6KB10.48220753
118PAK10.47814851
119TESK10.47747362
120RPS6KC10.47595286
121RPS6KL10.47595286
122CSNK1A10.46590542
123FES0.46531197
124MAPK40.46212488
125AURKA0.46028678
126IRAK20.45651448
127CDK190.45089074
128MAP3K110.44086790
129FGFR20.43027555
130PDGFRA0.42424626
131JAK20.42153814
132FER0.42022900
133WNK10.39794397
134PRKG20.38965081
135BLK0.38505303
136RPS6KA60.38120781
137PKN10.36480320
138MAPK80.36363804
139GRK70.35988581
140CSNK1E0.35488811
141PRKACA0.35276226
142EPHA30.34914491
143CDK80.33305810
144EPHB20.32831564
145SGK30.32557421
146PRKCH0.32331369
147ALK0.32073871
148SGK4940.31913440
149SGK2230.31913440
150STK110.31898232
151ROCK10.31609722
152RPS6KA50.31391564
153DMPK0.31359939
154CDK50.31189563
155HCK0.31034839
156PRPF4B0.31029417
157INSRR0.30951440
158PRKCZ0.30651714
159WNK40.27762073
160CAMK2A0.27500791

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002203.38989726
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29234270
3Other glycan degradation_Homo sapiens_hsa005112.90625489
4Collecting duct acid secretion_Homo sapiens_hsa049662.44416204
5Nitrogen metabolism_Homo sapiens_hsa009102.36442787
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.34286335
7Gap junction_Homo sapiens_hsa045402.26729368
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.11889506
9Phagosome_Homo sapiens_hsa041451.94841949
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.90426042
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81927643
12Fructose and mannose metabolism_Homo sapiens_hsa000511.80813427
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78650414
14Dopaminergic synapse_Homo sapiens_hsa047281.68805874
15Biosynthesis of amino acids_Homo sapiens_hsa012301.68313157
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67736872
17Fatty acid degradation_Homo sapiens_hsa000711.67074698
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66533460
19Vibrio cholerae infection_Homo sapiens_hsa051101.64804816
20Bile secretion_Homo sapiens_hsa049761.64722167
21Complement and coagulation cascades_Homo sapiens_hsa046101.61147197
22Starch and sucrose metabolism_Homo sapiens_hsa005001.58235384
23Pyruvate metabolism_Homo sapiens_hsa006201.55736657
24Glutamatergic synapse_Homo sapiens_hsa047241.53899679
25Synaptic vesicle cycle_Homo sapiens_hsa047211.53206470
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50899204
27Carbon metabolism_Homo sapiens_hsa012001.50087161
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.47925435
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47873577
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47601738
31Cocaine addiction_Homo sapiens_hsa050301.42211870
32Long-term potentiation_Homo sapiens_hsa047201.41006324
33Fatty acid metabolism_Homo sapiens_hsa012121.39831245
34Propanoate metabolism_Homo sapiens_hsa006401.39367440
35Rheumatoid arthritis_Homo sapiens_hsa053231.36357170
36PPAR signaling pathway_Homo sapiens_hsa033201.34925896
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33873928
38Staphylococcus aureus infection_Homo sapiens_hsa051501.33075827
39Cardiac muscle contraction_Homo sapiens_hsa042601.32049974
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30138236
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28602942
42Pentose phosphate pathway_Homo sapiens_hsa000301.27489734
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26852450
44Tryptophan metabolism_Homo sapiens_hsa003801.24585478
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23991725
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22264483
47Galactose metabolism_Homo sapiens_hsa000521.20741824
48Phototransduction_Homo sapiens_hsa047441.18606784
49VEGF signaling pathway_Homo sapiens_hsa043701.17428086
50Salmonella infection_Homo sapiens_hsa051321.16986089
51Axon guidance_Homo sapiens_hsa043601.15114885
52Glucagon signaling pathway_Homo sapiens_hsa049221.11960921
53Arginine and proline metabolism_Homo sapiens_hsa003301.11259480
54Circadian rhythm_Homo sapiens_hsa047101.10613777
55Oxidative phosphorylation_Homo sapiens_hsa001901.09725978
56Dilated cardiomyopathy_Homo sapiens_hsa054141.05059410
57Insulin signaling pathway_Homo sapiens_hsa049101.04318000
58Long-term depression_Homo sapiens_hsa047301.02954447
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02776610
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02733947
61Amphetamine addiction_Homo sapiens_hsa050311.01873782
62Parkinsons disease_Homo sapiens_hsa050121.01647021
63Butanoate metabolism_Homo sapiens_hsa006500.99977027
64Insulin resistance_Homo sapiens_hsa049310.99479792
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99242393
66ABC transporters_Homo sapiens_hsa020100.98809112
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95359922
68Oxytocin signaling pathway_Homo sapiens_hsa049210.94411439
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94185573
70GABAergic synapse_Homo sapiens_hsa047270.93343436
71Renin secretion_Homo sapiens_hsa049240.92420867
72Prion diseases_Homo sapiens_hsa050200.92209404
73Melanogenesis_Homo sapiens_hsa049160.92170236
74Notch signaling pathway_Homo sapiens_hsa043300.91200090
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89792665
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89563556
77Salivary secretion_Homo sapiens_hsa049700.89022327
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.86806737
79Alzheimers disease_Homo sapiens_hsa050100.86611628
80Osteoclast differentiation_Homo sapiens_hsa043800.86553285
81MAPK signaling pathway_Homo sapiens_hsa040100.83747584
82Olfactory transduction_Homo sapiens_hsa047400.83224325
83Circadian entrainment_Homo sapiens_hsa047130.81721186
84Insulin secretion_Homo sapiens_hsa049110.81623067
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81079371
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80764927
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.80445437
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.79155353
89Hedgehog signaling pathway_Homo sapiens_hsa043400.78465244
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77415201
91Peroxisome_Homo sapiens_hsa041460.77079303
92Phenylalanine metabolism_Homo sapiens_hsa003600.76858934
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76834500
94AMPK signaling pathway_Homo sapiens_hsa041520.76199218
95Sulfur relay system_Homo sapiens_hsa041220.75490583
96Calcium signaling pathway_Homo sapiens_hsa040200.75445038
97Serotonergic synapse_Homo sapiens_hsa047260.75185854
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74120602
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.72992747
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72918825
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72492204
102Sphingolipid metabolism_Homo sapiens_hsa006000.71984443
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71253976
104Endocytosis_Homo sapiens_hsa041440.68872634
105Estrogen signaling pathway_Homo sapiens_hsa049150.68690677
106Type II diabetes mellitus_Homo sapiens_hsa049300.67812736
107Tuberculosis_Homo sapiens_hsa051520.67198007
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66419667
109Fatty acid elongation_Homo sapiens_hsa000620.64861413
110Ras signaling pathway_Homo sapiens_hsa040140.64012785
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63419898
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.63307613
113mTOR signaling pathway_Homo sapiens_hsa041500.62215680
114Morphine addiction_Homo sapiens_hsa050320.61994747
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59844387
116beta-Alanine metabolism_Homo sapiens_hsa004100.59627389
117Nicotine addiction_Homo sapiens_hsa050330.59469248
118cAMP signaling pathway_Homo sapiens_hsa040240.59002711
119Pertussis_Homo sapiens_hsa051330.58079573
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58070102
121Apoptosis_Homo sapiens_hsa042100.58020137
122Malaria_Homo sapiens_hsa051440.57684131
123Mineral absorption_Homo sapiens_hsa049780.56148659
124Rap1 signaling pathway_Homo sapiens_hsa040150.55701906
125ErbB signaling pathway_Homo sapiens_hsa040120.54615089
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52082294
127Fat digestion and absorption_Homo sapiens_hsa049750.51626801
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51569642
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51307373
130Tyrosine metabolism_Homo sapiens_hsa003500.50188635
131Cholinergic synapse_Homo sapiens_hsa047250.49843005
132Glioma_Homo sapiens_hsa052140.49187725
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.48280454
134Fatty acid biosynthesis_Homo sapiens_hsa000610.47840052
135GnRH signaling pathway_Homo sapiens_hsa049120.47798650
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46704661
137Chemokine signaling pathway_Homo sapiens_hsa040620.46073393
138Steroid biosynthesis_Homo sapiens_hsa001000.45852072
139Chemical carcinogenesis_Homo sapiens_hsa052040.45090073
140Lysosome_Homo sapiens_hsa041420.44399432
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44332205
142Alcoholism_Homo sapiens_hsa050340.43720448
143Glycerolipid metabolism_Homo sapiens_hsa005610.41948674
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.41789388
145Caffeine metabolism_Homo sapiens_hsa002320.41590877
146Huntingtons disease_Homo sapiens_hsa050160.41220987
147Lysine degradation_Homo sapiens_hsa003100.40622020
148Retinol metabolism_Homo sapiens_hsa008300.40113420
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40028933
150Amoebiasis_Homo sapiens_hsa051460.39645878
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39437255
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.39346389
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39272502
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.38934821
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.38468184
156Dorso-ventral axis formation_Homo sapiens_hsa043200.38009872
157HIF-1 signaling pathway_Homo sapiens_hsa040660.37757211
158Gastric acid secretion_Homo sapiens_hsa049710.37455899
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36422368
160Taste transduction_Homo sapiens_hsa047420.36284083
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35874177
162Wnt signaling pathway_Homo sapiens_hsa043100.35752196
163Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35574474

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »