TPD52L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22400180
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02026075
3ATP synthesis coupled proton transport (GO:0015986)4.02026075
4protein localization to synapse (GO:0035418)3.99062565
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81016626
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.77030407
7vocalization behavior (GO:0071625)3.60631918
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55702207
9desmosome organization (GO:0002934)3.49559985
10synaptic vesicle exocytosis (GO:0016079)3.48720530
11glucocorticoid biosynthetic process (GO:0006704)3.45693142
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44017947
13synaptic vesicle docking involved in exocytosis (GO:0016081)3.42909937
14regulation of glutamate secretion (GO:0014048)3.35730675
15respiratory electron transport chain (GO:0022904)3.33803405
16regulation of glutamate receptor signaling pathway (GO:1900449)3.31597104
17electron transport chain (GO:0022900)3.29608666
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29552193
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.27941711
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.26473696
21glutamate secretion (GO:0014047)3.26205188
22neurotransmitter-gated ion channel clustering (GO:0072578)3.24979378
23neuron cell-cell adhesion (GO:0007158)3.23900731
24auditory receptor cell stereocilium organization (GO:0060088)3.17226971
25regulation of synaptic vesicle exocytosis (GO:2000300)3.12252908
26regulation of hippo signaling (GO:0035330)3.11407321
27righting reflex (GO:0060013)3.09780614
28cullin deneddylation (GO:0010388)3.07376604
29negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07081727
30neurotransmitter secretion (GO:0007269)3.06115822
31cellular ketone body metabolic process (GO:0046950)3.04850824
32ketone body metabolic process (GO:1902224)3.03146252
33female mating behavior (GO:0060180)3.01123326
34ATP hydrolysis coupled proton transport (GO:0015991)3.00935694
35energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00935694
36skeletal muscle adaptation (GO:0043501)2.96158603
37regulation of skeletal muscle contraction (GO:0014819)2.92464051
38serotonin metabolic process (GO:0042428)2.88717323
39dicarboxylic acid catabolic process (GO:0043649)2.86971329
40regulation of protein kinase A signaling (GO:0010738)2.86952842
41flavonoid metabolic process (GO:0009812)2.84484971
42fear response (GO:0042596)2.83726414
43neuron-neuron synaptic transmission (GO:0007270)2.81049242
44behavioral response to cocaine (GO:0048148)2.81019720
45androgen biosynthetic process (GO:0006702)2.80686841
46response to histamine (GO:0034776)2.80684591
47biotin metabolic process (GO:0006768)2.80194667
48branched-chain amino acid catabolic process (GO:0009083)2.79878517
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78749030
50glutamate receptor signaling pathway (GO:0007215)2.78077864
51regulation of synaptic vesicle transport (GO:1902803)2.76864058
52regulation of female receptivity (GO:0045924)2.76833329
53postsynaptic membrane organization (GO:0001941)2.75847663
54intestinal epithelial cell development (GO:0060576)2.74866849
55behavioral fear response (GO:0001662)2.74145262
56behavioral defense response (GO:0002209)2.74145262
57exploration behavior (GO:0035640)2.74058893
58negative regulation of keratinocyte proliferation (GO:0010839)2.73530145
59gamma-aminobutyric acid signaling pathway (GO:0007214)2.72131287
60neuronal action potential propagation (GO:0019227)2.70302321
61cochlea development (GO:0090102)2.70149133
62bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69565855
63reflex (GO:0060004)2.69266354
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68919906
65diterpenoid biosynthetic process (GO:0016102)2.68841733
66chaperone-mediated protein transport (GO:0072321)2.68715877
67primary amino compound metabolic process (GO:1901160)2.67129694
68neuron recognition (GO:0008038)2.65963118
69ATP biosynthetic process (GO:0006754)2.65284214
70positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65200109
71protein deneddylation (GO:0000338)2.63320234
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62637478
73synaptic transmission, glutamatergic (GO:0035249)2.59889437
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59471472
75kynurenine metabolic process (GO:0070189)2.58570692
76benzene-containing compound metabolic process (GO:0042537)2.58561100
77negative regulation of amino acid transport (GO:0051956)2.58532396
78dopamine transport (GO:0015872)2.58494779
79regulation of neuronal synaptic plasticity (GO:0048168)2.58413835
80striated muscle atrophy (GO:0014891)2.58403332
81cardiac right ventricle morphogenesis (GO:0003215)2.58137696
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57598464
83L-phenylalanine metabolic process (GO:0006558)2.57598464
84neurotransmitter transport (GO:0006836)2.57229049
85neuromuscular synaptic transmission (GO:0007274)2.56499967
86regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55741925
87behavioral response to ethanol (GO:0048149)2.54103082
88regulation of oxidative phosphorylation (GO:0002082)2.53417868
89ionotropic glutamate receptor signaling pathway (GO:0035235)2.53383042
90regulation of postsynaptic membrane potential (GO:0060078)2.52334540
91purine nucleoside triphosphate biosynthetic process (GO:0009145)2.52249967
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.51519543
93ubiquinone biosynthetic process (GO:0006744)2.51066587
94long-term synaptic potentiation (GO:0060291)2.49987054
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.49081202
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48493550
97presynaptic membrane assembly (GO:0097105)2.47100897
98L-methionine salvage (GO:0071267)2.46998828
99L-methionine biosynthetic process (GO:0071265)2.46998828
100amino acid salvage (GO:0043102)2.46998828
101prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46271267
102anterior/posterior axis specification, embryo (GO:0008595)2.43882650
103gonadal mesoderm development (GO:0007506)2.42886565
104negative regulation of protein localization to cell surface (GO:2000009)2.41841805
105fatty acid transmembrane transport (GO:1902001)2.41483298
106glucocorticoid metabolic process (GO:0008211)2.39742502
107methionine biosynthetic process (GO:0009086)2.39435796
108retinal metabolic process (GO:0042574)2.39353678
109response to pheromone (GO:0019236)2.39319259
110hydrogen ion transmembrane transport (GO:1902600)2.38748813
111norepinephrine metabolic process (GO:0042415)2.37974549
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36200872
113positive regulation of membrane potential (GO:0045838)2.35397503
114regulation of centriole replication (GO:0046599)2.35230415
115regulation of neurotransmitter levels (GO:0001505)2.35149432
116behavioral response to nicotine (GO:0035095)2.34807192
117regulation of neurotransmitter secretion (GO:0046928)2.34713949
118regulation of vesicle fusion (GO:0031338)2.34430383
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.33760149
120catecholamine transport (GO:0051937)2.33385838
121phenylpropanoid metabolic process (GO:0009698)2.32869013
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32703448
123long-term memory (GO:0007616)2.32379408
124inner mitochondrial membrane organization (GO:0007007)2.32250418
125positive regulation of synapse maturation (GO:0090129)2.31915327
126regulation of cell communication by electrical coupling (GO:0010649)2.31639096
127muscle atrophy (GO:0014889)2.31564562
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.31392963
129tryptophan catabolic process (GO:0006569)2.30545046
130indole-containing compound catabolic process (GO:0042436)2.30545046
131indolalkylamine catabolic process (GO:0046218)2.30545046
132ubiquinone metabolic process (GO:0006743)2.29933666
133water-soluble vitamin biosynthetic process (GO:0042364)2.29821207
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29385837
135synaptic transmission, dopaminergic (GO:0001963)2.29143416
136transferrin transport (GO:0033572)2.29122107
137regulation of synaptic plasticity (GO:0048167)2.28056475
138regulation of dendritic spine morphogenesis (GO:0061001)2.27942722
139transmission of nerve impulse (GO:0019226)2.27938804
140oxidative demethylation (GO:0070989)2.27923325
141axonal fasciculation (GO:0007413)2.27632283
142locomotory exploration behavior (GO:0035641)2.27282291
143negative regulation of amine transport (GO:0051953)2.26187202
144branched-chain amino acid metabolic process (GO:0009081)2.25724346
145positive regulation of synapse assembly (GO:0051965)2.25673543
146positive regulation of neurotransmitter secretion (GO:0001956)2.25623640
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.25617379
148oxaloacetate metabolic process (GO:0006107)2.25442849
149regulation of lipoprotein metabolic process (GO:0050746)2.25416986
150positive regulation of neurotransmitter transport (GO:0051590)2.25316748
151signal peptide processing (GO:0006465)2.25209256
152oxidative phosphorylation (GO:0006119)2.24825225
153keratinocyte development (GO:0003334)2.23470631
154short-term memory (GO:0007614)2.23161241
155synaptic vesicle endocytosis (GO:0048488)2.21779721
156regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.21302535
157aromatic amino acid family catabolic process (GO:0009074)2.21258667
158nephron tubule morphogenesis (GO:0072078)2.20284847
159epithelial cell maturation (GO:0002070)2.20157166
160nitric oxide biosynthetic process (GO:0006809)2.19701307
161plasma membrane repair (GO:0001778)2.19588586
162dicarboxylic acid biosynthetic process (GO:0043650)2.19490609
163inositol metabolic process (GO:0006020)2.19151371
164quaternary ammonium group transport (GO:0015697)2.18426317
165neurotransmitter catabolic process (GO:0042135)2.18198456
166regulation of acrosome reaction (GO:0060046)2.17957279
167regulation of establishment or maintenance of cell polarity (GO:0032878)2.17704463
168purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.16771796
1693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.16771796
170coenzyme catabolic process (GO:0009109)2.16222158
171regulation of water loss via skin (GO:0033561)2.15704476
172amino-acid betaine transport (GO:0015838)2.13525885
173carnitine transport (GO:0015879)2.13525885
174glomerular basement membrane development (GO:0032836)2.13011308
175ventricular cardiac muscle cell action potential (GO:0086005)2.12824542
176mesonephros development (GO:0001823)2.12591462
177short-chain fatty acid metabolic process (GO:0046459)2.11756603
178regulation of cell proliferation involved in kidney development (GO:1901722)2.11607953
179establishment of skin barrier (GO:0061436)2.11146956
180aromatic amino acid family metabolic process (GO:0009072)2.11038160
181regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.10834333
182erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.10811491
183L-phenylalanine catabolic process (GO:0006559)2.10811491
184carnitine shuttle (GO:0006853)2.09573223
185prostate gland growth (GO:0060736)2.09050538
186aspartate family amino acid catabolic process (GO:0009068)2.08864819
187myotube differentiation (GO:0014902)2.08732725
188regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.07630110
189muscle filament sliding (GO:0030049)2.07515465
190actin-myosin filament sliding (GO:0033275)2.07515465
191response to nitrosative stress (GO:0051409)2.06643212
192glutathione derivative biosynthetic process (GO:1901687)2.06260644
193glutathione derivative metabolic process (GO:1901685)2.06260644
194regulation of keratinocyte proliferation (GO:0010837)2.06088606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human4.19897492
2* ESR1_21235772_ChIP-Seq_MCF-7_Human3.63550950
3EZH2_22144423_ChIP-Seq_EOC_Human3.36700388
4GBX2_23144817_ChIP-Seq_PC3_Human2.92587392
5* ESR2_21235772_ChIP-Seq_MCF-7_Human2.70572880
6ER_23166858_ChIP-Seq_MCF-7_Human2.38692832
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27421492
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27109265
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14467996
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13852616
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.11580447
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.05905056
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03435473
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02803554
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01272728
16FOXM1_26456572_ChIP-Seq_MCF-7_Human2.01062033
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98421016
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96615455
19REST_21632747_ChIP-Seq_MESCs_Mouse1.94765962
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92027747
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.91123883
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87410208
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86041412
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77550563
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77547736
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77527533
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77527533
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77393717
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75380052
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.74736379
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.71748193
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71482449
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70638481
34TAF15_26573619_Chip-Seq_HEK293_Human1.69541034
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68961978
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.68020323
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.67933322
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67057839
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66895150
40* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62291113
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59863790
42FUS_26573619_Chip-Seq_HEK293_Human1.58286914
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58208709
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57596850
45VDR_22108803_ChIP-Seq_LS180_Human1.50533820
46ZNF274_21170338_ChIP-Seq_K562_Hela1.45473564
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44849064
48* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41487168
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.40073864
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39177976
51IGF1R_20145208_ChIP-Seq_DFB_Human1.39006997
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38713935
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.38587453
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.36923783
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36811307
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.36598482
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35210899
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34497358
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34496199
60AR_21572438_ChIP-Seq_LNCaP_Human1.32856285
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32597081
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.31259226
63TCF4_23295773_ChIP-Seq_U87_Human1.30226375
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30078892
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30078892
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30078892
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.29482111
68P300_19829295_ChIP-Seq_ESCs_Human1.29063047
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28966454
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27117722
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.24952558
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23680393
73RNF2_27304074_Chip-Seq_NSC_Mouse1.23146218
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22258915
75STAT3_23295773_ChIP-Seq_U87_Human1.19843001
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17151358
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15901590
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14741207
79HTT_18923047_ChIP-ChIP_STHdh_Human1.14397249
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14296311
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14086186
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.13937871
83* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13768980
84* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13768980
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13109572
86HOXB7_26014856_ChIP-Seq_BT474_Human1.12403380
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11456292
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10923387
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10474293
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10113202
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09146937
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08858969
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08284602
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06778972
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06255221
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05705382
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05412226
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04709581
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.04567702
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04174776
101CBP_20019798_ChIP-Seq_JUKART_Human1.04174776
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03207235
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02650921
104* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02457205
105* AR_25329375_ChIP-Seq_VCAP_Human1.02012680
106CJUN_26792858_Chip-Seq_BT549_Human1.01742548
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00521613
108* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00325025
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.00041920
110TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99660271
111TCF4_22108803_ChIP-Seq_LS180_Human0.99311931
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98351713
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98003842
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97775579
115TP53_22573176_ChIP-Seq_HFKS_Human0.97384332
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96434801
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95969659
118ELF5_23300383_ChIP-Seq_T47D_Human0.94041627
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92889338
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92682296
121BCAT_22108803_ChIP-Seq_LS180_Human0.92296840
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.91586363
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90770128
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90697681
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.90195590
126REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90073883
127CDX2_22108803_ChIP-Seq_LS180_Human0.88839887
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88272921
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.87332995
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.87097025
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86991865
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86256578
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86206432
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86145611
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85800972
136GATA1_22025678_ChIP-Seq_K562_Human0.85591796
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.85348576
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85348576
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85050404
140ZNF263_19887448_ChIP-Seq_K562_Human0.84662038
141JUN_21703547_ChIP-Seq_K562_Human0.84608319
142RUNX2_22187159_ChIP-Seq_PCA_Human0.84274259
143GATA4_25053715_ChIP-Seq_YYC3_Human0.84271078
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.83816841
145TP53_18474530_ChIP-ChIP_U2OS_Human0.83524093
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83508238
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83502205
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83385082
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83141938
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.82898969
151PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82223652
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81983366
153* FOXA1_25552417_ChIP-Seq_VCAP_Human0.81923035
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81882087
155AR_20517297_ChIP-Seq_VCAP_Human0.81549443
156DROSHA_22980978_ChIP-Seq_HELA_Human0.81500301
157EWS_26573619_Chip-Seq_HEK293_Human0.81215817
158* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81089315
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80226943
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.80166993
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.80010358
162* CRX_20693478_ChIP-Seq_RETINA_Mouse0.79760909
163POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79724962
164AHR_22903824_ChIP-Seq_MCF-7_Human0.79569818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.73987703
2MP0002822_catalepsy3.51945756
3MP0004859_abnormal_synaptic_plasticity3.50660970
4MP0003635_abnormal_synaptic_transmissio2.61292357
5MP0000383_abnormal_hair_follicle2.55530622
6MP0009745_abnormal_behavioral_response2.43359448
7MP0003123_paternal_imprinting2.35919273
8MP0000579_abnormal_nail_morphology2.28135521
9MP0009780_abnormal_chondrocyte_physiolo2.21900970
10MP0001968_abnormal_touch/_nociception2.20379980
11MP0002063_abnormal_learning/memory/cond2.19541151
12MP0003122_maternal_imprinting2.18663602
13MP0004270_analgesia2.16682234
14MP0000427_abnormal_hair_cycle2.09803603
15MP0010678_abnormal_skin_adnexa2.05562381
16MP0002064_seizures2.01315235
17MP0006276_abnormal_autonomic_nervous1.98743399
18MP0002572_abnormal_emotion/affect_behav1.95649523
19MP0002837_dystrophic_cardiac_calcinosis1.93525204
20MP0004145_abnormal_muscle_electrophysio1.92264108
21MP0001529_abnormal_vocalization1.91265901
22MP0001440_abnormal_grooming_behavior1.90342359
23MP0003011_delayed_dark_adaptation1.87284078
24MP0003941_abnormal_skin_development1.85987875
25MP0002734_abnormal_mechanical_nocicepti1.77391027
26MP0008995_early_reproductive_senescence1.76157721
27MP0005423_abnormal_somatic_nervous1.76149333
28MP0003878_abnormal_ear_physiology1.69455006
29MP0005377_hearing/vestibular/ear_phenot1.69455006
30MP0009046_muscle_twitch1.66717501
31MP0002736_abnormal_nociception_after1.65834285
32MP0002272_abnormal_nervous_system1.65604093
33MP0000751_myopathy1.63739877
34MP0008875_abnormal_xenobiotic_pharmacok1.58067900
35MP0009379_abnormal_foot_pigmentation1.51060683
36MP0004264_abnormal_extraembryonic_tissu1.49949240
37MP0002098_abnormal_vibrissa_morphology1.47896287
38MP0004133_heterotaxia1.45526652
39MP0004147_increased_porphyrin_level1.45208010
40MP0001501_abnormal_sleep_pattern1.43004084
41MP0005646_abnormal_pituitary_gland1.42107142
42MP0010234_abnormal_vibrissa_follicle1.38405346
43MP0005551_abnormal_eye_electrophysiolog1.35213433
44MP0003950_abnormal_plasma_membrane1.33767322
45MP0002796_impaired_skin_barrier1.33292097
46MP0004084_abnormal_cardiac_muscle1.33067301
47MP0004924_abnormal_behavior1.32958871
48MP0005386_behavior/neurological_phenoty1.32958871
49MP0002184_abnormal_innervation1.31609218
50MP0002909_abnormal_adrenal_gland1.31035283
51MP0002733_abnormal_thermal_nociception1.29297343
52MP0000372_irregular_coat_pigmentation1.28763527
53MP0002234_abnormal_pharynx_morphology1.28083395
54MP0005187_abnormal_penis_morphology1.27252401
55MP0004233_abnormal_muscle_weight1.26688603
56MP0002067_abnormal_sensory_capabilities1.25493996
57MP0010386_abnormal_urinary_bladder1.25130207
58MP0004381_abnormal_hair_follicle1.24889439
59MP0002735_abnormal_chemical_nociception1.24819050
60MP0002557_abnormal_social/conspecific_i1.23781551
61MP0003136_yellow_coat_color1.23770905
62MP0000647_abnormal_sebaceous_gland1.23178396
63MP0003195_calcinosis1.23037428
64MP0001970_abnormal_pain_threshold1.22925362
65MP0000778_abnormal_nervous_system1.21922784
66MP0003121_genomic_imprinting1.18948971
67MP0002938_white_spotting1.15946071
68MP0004043_abnormal_pH_regulation1.15693773
69MP0001486_abnormal_startle_reflex1.15273817
70MP0003283_abnormal_digestive_organ1.15062503
71MP0004142_abnormal_muscle_tone1.12157226
72MP0000467_abnormal_esophagus_morphology1.10227843
73MP0000955_abnormal_spinal_cord1.08861053
74MP0001905_abnormal_dopamine_level1.08490056
75MP0001485_abnormal_pinna_reflex1.07693537
76MP0005670_abnormal_white_adipose1.06937386
77MP0000462_abnormal_digestive_system1.06600837
78MP0002876_abnormal_thyroid_physiology1.05745775
79MP0003806_abnormal_nucleotide_metabolis1.05468242
80MP0005503_abnormal_tendon_morphology1.05098700
81MP0005248_abnormal_Harderian_gland1.03707860
82MP0005085_abnormal_gallbladder_physiolo1.03566319
83MP0001661_extended_life_span1.01754219
84MP0002653_abnormal_ependyma_morphology1.01603440
85MP0004036_abnormal_muscle_relaxation0.97609054
86MP0008057_abnormal_DNA_replication0.97482320
87MP0000566_synostosis0.97337494
88MP0003787_abnormal_imprinting0.97129739
89MP0003879_abnormal_hair_cell0.97046026
90MP0004085_abnormal_heartbeat0.96970438
91MP0005171_absent_coat_pigmentation0.96543390
92MP0001188_hyperpigmentation0.96393534
93MP0005330_cardiomyopathy0.94000386
94MP0002066_abnormal_motor_capabilities/c0.92987021
95MP0010030_abnormal_orbit_morphology0.92099703
96MP0002108_abnormal_muscle_morphology0.91354417
97MP0003119_abnormal_digestive_system0.91148254
98MP0005253_abnormal_eye_physiology0.90854846
99MP0000377_abnormal_hair_follicle0.89835430
100MP0004215_abnormal_myocardial_fiber0.87599363
101MP0001984_abnormal_olfaction0.87402665
102MP0003329_amyloid_beta_deposits0.87241170
103MP0000537_abnormal_urethra_morphology0.86616543
104MP0000631_abnormal_neuroendocrine_gland0.86115264
105MP0004782_abnormal_surfactant_physiolog0.85906013
106MP0002882_abnormal_neuron_morphology0.85592126
107MP0001664_abnormal_digestion0.85391900
108MP0006035_abnormal_mitochondrial_morpho0.85149450
109MP0000538_abnormal_urinary_bladder0.85101724
110MP0005083_abnormal_biliary_tract0.81428878
111MP0006072_abnormal_retinal_apoptosis0.81142531
112MP0003646_muscle_fatigue0.80583671
113MP0000762_abnormal_tongue_morphology0.80315702
114MP0002269_muscular_atrophy0.79821727
115MP0002332_abnormal_exercise_endurance0.79234961
116MP0005636_abnormal_mineral_homeostasis0.78610590
117MP0002152_abnormal_brain_morphology0.78574692
118MP0005408_hypopigmentation0.78495090
119MP0005620_abnormal_muscle_contractility0.78052518
120MP0003137_abnormal_impulse_conducting0.78035303
121MP0002127_abnormal_cardiovascular_syste0.77984347
122MP0002069_abnormal_eating/drinking_beha0.77064453
123MP0004019_abnormal_vitamin_homeostasis0.76811817
124MP0003638_abnormal_response/metabolism_0.76396889
125MP0008872_abnormal_physiological_respon0.75399010
126MP0009697_abnormal_copulation0.75016641
127MP0000749_muscle_degeneration0.74760093
128MP0004272_abnormal_basement_membrane0.74590009
129MP0006036_abnormal_mitochondrial_physio0.74018502
130MP0005623_abnormal_meninges_morphology0.73962901
131MP0003718_maternal_effect0.73870693
132MP0003890_abnormal_embryonic-extraembry0.73274756
133MP0000639_abnormal_adrenal_gland0.73166086
134MP0008775_abnormal_heart_ventricle0.73128983
135MP0004858_abnormal_nervous_system0.72873316
136MP0004130_abnormal_muscle_cell0.72774373
137MP0004811_abnormal_neuron_physiology0.72725917
138MP0003786_premature_aging0.72652428
139MP0000747_muscle_weakness0.72473260
140MP0010771_integument_phenotype0.72356305
141MP0000569_abnormal_digit_pigmentation0.71793132
142MP0004087_abnormal_muscle_fiber0.71260299
143MP0005332_abnormal_amino_acid0.71211331
144MP0005535_abnormal_body_temperature0.70963122
145MP0005501_abnormal_skin_physiology0.70677857
146MP0001666_abnormal_nutrient_absorption0.70447514
147MP0002139_abnormal_hepatobiliary_system0.69962789
148MP0003936_abnormal_reproductive_system0.69915078
149MP0000750_abnormal_muscle_regeneration0.69223956
150MP0002160_abnormal_reproductive_system0.68485517
151MP0000627_abnormal_mammary_gland0.68386867
152MP0005645_abnormal_hypothalamus_physiol0.66985507
153MP0000013_abnormal_adipose_tissue0.66716199
154MP0005369_muscle_phenotype0.63314725

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.76389111
2Myokymia (HP:0002411)3.96438780
3Acute necrotizing encephalopathy (HP:0006965)3.91116383
4Concave nail (HP:0001598)3.81734606
5Atonic seizures (HP:0010819)3.76942181
6Abnormal mitochondria in muscle tissue (HP:0008316)3.56675202
7Acute encephalopathy (HP:0006846)3.43213255
8Progressive macrocephaly (HP:0004481)3.25687482
9Hyperventilation (HP:0002883)3.25134508
10Focal seizures (HP:0007359)3.21770597
11Epileptic encephalopathy (HP:0200134)3.00262488
12Absence seizures (HP:0002121)2.89623460
13Hyporeflexia of lower limbs (HP:0002600)2.88183752
14Abnormality of alanine metabolism (HP:0010916)2.79951875
15Hyperalaninemia (HP:0003348)2.79951875
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79951875
17Mitochondrial inheritance (HP:0001427)2.76296974
18Dialeptic seizures (HP:0011146)2.76035125
19Visual hallucinations (HP:0002367)2.72471374
20Cerebral edema (HP:0002181)2.66251963
21Gaze-evoked nystagmus (HP:0000640)2.53114812
22Right ventricular cardiomyopathy (HP:0011663)2.52585825
23Bundle branch block (HP:0011710)2.52481529
24Amelogenesis imperfecta (HP:0000705)2.45287766
25Exercise-induced muscle cramps (HP:0003710)2.44884533
26Pili torti (HP:0003777)2.43565330
27Exercise-induced myalgia (HP:0003738)2.42318918
28Increased CSF lactate (HP:0002490)2.41547763
29Generalized tonic-clonic seizures (HP:0002069)2.39969402
30Decreased circulating renin level (HP:0003351)2.31189587
31Febrile seizures (HP:0002373)2.28574668
32Pancreatic cysts (HP:0001737)2.26217495
33Hyperglycinuria (HP:0003108)2.21428999
34Broad-based gait (HP:0002136)2.21112141
35Abnormality of the lower motor neuron (HP:0002366)2.19746525
36Proximal tubulopathy (HP:0000114)2.15283016
37Abnormality of the renal cortex (HP:0011035)2.08280019
38Microglossia (HP:0000171)2.08053638
39Syncope (HP:0001279)2.07828206
40Septate vagina (HP:0001153)2.07677553
41Amblyopia (HP:0000646)2.06651916
42Progressive cerebellar ataxia (HP:0002073)2.05630833
43Abnormality of nail color (HP:0100643)2.05615042
44Hypothermia (HP:0002045)2.05384080
45Chromsome breakage (HP:0040012)2.02507753
46Exercise intolerance (HP:0003546)2.02105168
47Abnormality of the labia minora (HP:0012880)2.01665170
48Orthostatic hypotension (HP:0001278)2.01524875
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00767305
50Rimmed vacuoles (HP:0003805)2.00674443
51Pheochromocytoma (HP:0002666)1.99573724
52Abnormality of glycolysis (HP:0004366)1.98872335
53Increased serum pyruvate (HP:0003542)1.98872335
54Type II lissencephaly (HP:0007260)1.96645965
55Renal cortical cysts (HP:0000803)1.96333740
56Delusions (HP:0000746)1.95948006
57Areflexia of lower limbs (HP:0002522)1.94174225
58Anxiety (HP:0000739)1.93772188
59Epileptiform EEG discharges (HP:0011182)1.93569927
60Furrowed tongue (HP:0000221)1.93526098
61Muscle hypertrophy of the lower extremities (HP:0008968)1.93165842
62Heart block (HP:0012722)1.92525203
63Myotonia (HP:0002486)1.91003129
64Hypotrichosis (HP:0001006)1.88625937
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.88408826
66Optic disc pallor (HP:0000543)1.87503822
67Status epilepticus (HP:0002133)1.87153472
68Hyperaldosteronism (HP:0000859)1.85321625
69Cerebellar dysplasia (HP:0007033)1.85230254
70Hepatocellular necrosis (HP:0001404)1.85087719
71Abnormal hair laboratory examination (HP:0003328)1.84037218
72Shoulder girdle muscle weakness (HP:0003547)1.83648671
73Leukodystrophy (HP:0002415)1.83105438
74Hypoplastic left heart (HP:0004383)1.82253289
75Hyperkalemia (HP:0002153)1.80664920
76Lactic acidosis (HP:0003128)1.80129361
77EEG with generalized epileptiform discharges (HP:0011198)1.80048206
78Dysdiadochokinesis (HP:0002075)1.79206558
79Aplasia involving bones of the extremities (HP:0009825)1.79142454
80Aplasia involving bones of the upper limbs (HP:0009823)1.79142454
81Aplasia of the phalanges of the hand (HP:0009802)1.79142454
82Lip pit (HP:0100267)1.77556528
83Alopecia of scalp (HP:0002293)1.75849816
84Popliteal pterygium (HP:0009756)1.75845207
85Calf muscle hypertrophy (HP:0008981)1.75699254
86Type I transferrin isoform profile (HP:0003642)1.75482303
87Abnormal atrioventricular conduction (HP:0005150)1.74995745
88True hermaphroditism (HP:0010459)1.74276830
89Congenital sensorineural hearing impairment (HP:0008527)1.74219235
90J-shaped sella turcica (HP:0002680)1.73934501
91Fetal akinesia sequence (HP:0001989)1.73580571
92Unsteady gait (HP:0002317)1.73247571
93Hamartoma of the eye (HP:0010568)1.72833644
94Hypoplastic labia majora (HP:0000059)1.72217085
95Abnormality of renal resorption (HP:0011038)1.71954851
96Hypoplasia of the uterus (HP:0000013)1.71765346
97Central scotoma (HP:0000603)1.71674658
98Increased serum lactate (HP:0002151)1.71210429
99Hyperammonemia (HP:0001987)1.70491019
100Conjunctival hamartoma (HP:0100780)1.70266953
101Irregular epiphyses (HP:0010582)1.70072939
102Pancreatic fibrosis (HP:0100732)1.68718712
103Muscle stiffness (HP:0003552)1.67188695
104Fatigable weakness (HP:0003473)1.66857057
105Abnormality of the neuromuscular junction (HP:0003398)1.66857057
106Hypsarrhythmia (HP:0002521)1.66247056
107X-linked dominant inheritance (HP:0001423)1.66153465
108Abnormality of glycine metabolism (HP:0010895)1.66048331
109Abnormality of serine family amino acid metabolism (HP:0010894)1.66048331
110Ankle clonus (HP:0011448)1.65626075
111CNS demyelination (HP:0007305)1.65618513
112Neuroendocrine neoplasm (HP:0100634)1.65314502
113Congenital ichthyosiform erythroderma (HP:0007431)1.64987571
114Renal Fanconi syndrome (HP:0001994)1.64937744
115Abnormality of the labia majora (HP:0012881)1.64766697
116Large for gestational age (HP:0001520)1.64565462
117Respiratory failure (HP:0002878)1.64326035
118Abnormal gallbladder physiology (HP:0012438)1.63180552
119Cholecystitis (HP:0001082)1.63180552
120Gout (HP:0001997)1.62774467
121Palmoplantar hyperkeratosis (HP:0000972)1.62755589
122Lethargy (HP:0001254)1.62521583
123Myoglobinuria (HP:0002913)1.62000246
124Prolonged QT interval (HP:0001657)1.61862390
125Increased hepatocellular lipid droplets (HP:0006565)1.61468927
126Hypoplastic ischia (HP:0003175)1.61169424
127Hyperglycinemia (HP:0002154)1.60812304
128Lipid accumulation in hepatocytes (HP:0006561)1.60666789
129Abnormality of the calf musculature (HP:0001430)1.60078739
130Muscle fiber inclusion bodies (HP:0100299)1.59727352
131Aplasia/hypoplasia of the uterus (HP:0008684)1.59470846
132Type 1 muscle fiber predominance (HP:0003803)1.58690939
133Sparse eyelashes (HP:0000653)1.57286377
134Male pseudohermaphroditism (HP:0000037)1.57062063
135Testicular neoplasm (HP:0010788)1.56817596
136Poor suck (HP:0002033)1.56692032
137Shawl scrotum (HP:0000049)1.55350663
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.54397228
139Absent phalangeal crease (HP:0006109)1.53628019
140Gait imbalance (HP:0002141)1.52888156
141Depressed nasal tip (HP:0000437)1.52736345
142Emotional lability (HP:0000712)1.52520939
143Metabolic acidosis (HP:0001942)1.52308166
144Abnormality of secondary sexual hair (HP:0009888)1.52306157
145Abnormality of the axillary hair (HP:0100134)1.52306157
146Abnormal finger flexion creases (HP:0006143)1.52234876
147Ketosis (HP:0001946)1.52183419
148Medial flaring of the eyebrow (HP:0010747)1.52149873
149Impaired vibration sensation in the lower limbs (HP:0002166)1.52119658
150Hepatic necrosis (HP:0002605)1.51131431
151Distal lower limb muscle weakness (HP:0009053)1.51067355
152Testicular atrophy (HP:0000029)1.50432234
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.50127915
154Generalized aminoaciduria (HP:0002909)1.50057975
155Renal salt wasting (HP:0000127)1.49855411
156Plantar hyperkeratosis (HP:0007556)1.49733100
157Poor eye contact (HP:0000817)1.49652287
158Ketoacidosis (HP:0001993)1.47590548
159Craniofacial dystonia (HP:0012179)1.47133263
160Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.47107015
161Distal arthrogryposis (HP:0005684)1.46335488
162Abnormal autonomic nervous system physiology (HP:0012332)1.46160617
163Failure to thrive in infancy (HP:0001531)1.44393721
164Hypoplastic heart (HP:0001961)1.44345066
165Focal dystonia (HP:0004373)1.43813988
166Sudden death (HP:0001699)1.43397389
167Nemaline bodies (HP:0003798)1.42867356
168Abnormality of the ischium (HP:0003174)1.41641996
169Epiphyseal dysplasia (HP:0002656)1.41589212
170Increased intramyocellular lipid droplets (HP:0012240)1.41559832
171Congenital primary aphakia (HP:0007707)1.41076305
172Oligomenorrhea (HP:0000876)1.40234910
173Vitreoretinal degeneration (HP:0000655)1.40123467
174Torticollis (HP:0000473)1.39807106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.12308789
2NTRK34.00420102
3EPHA43.66603864
4AKT33.34034917
5CASK3.12929091
6MAP3K122.66997726
7MAP3K92.56363766
8MST1R2.53546733
9NME12.48096423
10MAP3K42.32728181
11RPS6KB22.19359112
12ARAF2.14553398
13DAPK22.09598730
14PIK3CG2.03564589
15BMPR1B2.00486353
16PBK1.97595620
17MAP2K41.89572660
18MINK11.88251410
19MAP2K71.85892995
20PLK21.82645009
21PNCK1.79034512
22KSR11.65130913
23BCKDK1.63972951
24KSR21.62489315
25MET1.62024222
26LATS21.59930005
27WNK41.57384433
28DAPK11.54962461
29WNK31.53552175
30NEK11.51310449
31SCYL21.47172643
32BRAF1.46932035
33GRK51.46845453
34SIK11.36625959
35MST41.35374118
36PKN21.34722524
37EIF2AK11.33981135
38PTK2B1.32618229
39LATS11.32121829
40OBSCN1.28691273
41BCR1.27458577
42FER1.27153238
43NTRK11.17242386
44PRKCG1.17231395
45OXSR11.15063677
46TRIB31.14134881
47PHKG21.13213479
48PHKG11.13213479
49MARK11.12172390
50MAPK131.10588070
51MYLK1.09949766
52INSRR1.08041316
53PDK21.07122079
54ADRBK21.06618770
55STK391.05753084
56TRPM71.02854012
57PDK31.00485869
58PDK41.00485869
59CAMK2A1.00151149
60ACVR1B0.98809888
61NEK60.97798210
62EPHA20.97464606
63SIK30.95428057
64MAPKAPK50.95409157
65GRK10.94758918
66EIF2AK30.92495775
67PAK60.92182278
68TGFBR10.91106076
69ILK0.90190578
70GRK70.87405917
71TSSK60.87220356
72MAP3K20.84368155
73TTN0.83475086
74ADRBK10.82595076
75STK38L0.79925605
76CDK50.79272423
77FRK0.76176867
78BRSK20.76055665
79TRIM280.75979656
80PAK30.75664797
81BMPR20.75200435
82NUAK10.74411850
83PLK30.74132619
84NTRK20.74012060
85RAF10.73423576
86CAMK2B0.73139014
87CDK190.72910018
88UHMK10.70957042
89CAMKK10.70732722
90PRKD30.68780190
91RPS6KB10.67831130
92MAP2K10.67020357
93CDK180.66881292
94PRKAA10.66134077
95DAPK30.65746659
96CDK140.64621666
97PRKCI0.64102250
98LIMK10.63243567
99DDR20.63125485
100MAP4K20.62987680
101PRKAA20.62794103
102EEF2K0.62066842
103PRKCE0.61425539
104PRPF4B0.59169740
105WEE10.59027234
106AKT20.58177499
107MAPK120.57831538
108CDK150.57762170
109PIK3CA0.56211324
110TESK10.55651346
111CAMK10.55629087
112MAP3K60.55065955
113STK380.55065563
114STK30.54684501
115CAMK2G0.54506402
116ERBB30.53015560
117NME20.51776252
118TNK20.51229501
119DMPK0.50667199
120CSNK1E0.49901476
121DYRK1A0.49867829
122MAP2K60.49849796
123CDK11A0.49467733
124FGFR20.49035618
125ZAK0.46994865
126CCNB10.45767305
127CSNK1A10.45085077
128EIF2AK20.44530350
129TNIK0.43211015
130PINK10.42766007
131PRKACB0.42375143
132SGK10.40895155
133MAP3K70.40714155
134VRK20.39659255
135CDC42BPA0.39583711
136SGK4940.38815105
137SGK2230.38815105
138FGR0.38288851
139CAMK2D0.37271092
140MAP2K20.37141980
141CHUK0.36934168
142PRKG20.35836843
143BRSK10.35050725
144WNK10.35014460
145PDPK10.34264610
146PRKACA0.34224362
147CSNK1D0.34058967
148MELK0.33971910
149SGK20.33969926
150CAMKK20.31437360
151MAPKAPK30.29671527
152MAP3K110.29645993
153PRKCZ0.28179087

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.46023027
2Nicotine addiction_Homo sapiens_hsa050333.07127010
3Parkinsons disease_Homo sapiens_hsa050122.80164919
4Synaptic vesicle cycle_Homo sapiens_hsa047212.67026934
5Alzheimers disease_Homo sapiens_hsa050102.30477367
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.24407181
7Collecting duct acid secretion_Homo sapiens_hsa049662.22275613
8Amphetamine addiction_Homo sapiens_hsa050312.11698066
9Cardiac muscle contraction_Homo sapiens_hsa042602.07173102
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04076496
11Huntingtons disease_Homo sapiens_hsa050162.03273601
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98219131
13Long-term potentiation_Homo sapiens_hsa047201.94494945
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86484089
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84346208
16Vibrio cholerae infection_Homo sapiens_hsa051101.75365034
17Vitamin B6 metabolism_Homo sapiens_hsa007501.72500554
18GABAergic synapse_Homo sapiens_hsa047271.72358440
19beta-Alanine metabolism_Homo sapiens_hsa004101.69740665
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69172063
21Olfactory transduction_Homo sapiens_hsa047401.60653796
22Circadian entrainment_Homo sapiens_hsa047131.54333694
23Dopaminergic synapse_Homo sapiens_hsa047281.50916013
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49770579
25Nitrogen metabolism_Homo sapiens_hsa009101.48333484
26Histidine metabolism_Homo sapiens_hsa003401.47033243
27Morphine addiction_Homo sapiens_hsa050321.45667540
28Pyruvate metabolism_Homo sapiens_hsa006201.45197563
29Insulin secretion_Homo sapiens_hsa049111.42464406
30Chemical carcinogenesis_Homo sapiens_hsa052041.40971839
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38975779
32Protein export_Homo sapiens_hsa030601.37621303
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36079027
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33273698
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32679670
36Taste transduction_Homo sapiens_hsa047421.32339796
37Propanoate metabolism_Homo sapiens_hsa006401.32026145
38ABC transporters_Homo sapiens_hsa020101.30322927
39Glutamatergic synapse_Homo sapiens_hsa047241.25557352
40Retinol metabolism_Homo sapiens_hsa008301.25519710
41One carbon pool by folate_Homo sapiens_hsa006701.24218286
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24012299
43Cocaine addiction_Homo sapiens_hsa050301.23971838
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20883716
45Phenylalanine metabolism_Homo sapiens_hsa003601.19057277
46Fatty acid degradation_Homo sapiens_hsa000711.18375080
47Serotonergic synapse_Homo sapiens_hsa047261.17811218
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17403837
49Salivary secretion_Homo sapiens_hsa049701.17042345
50Tyrosine metabolism_Homo sapiens_hsa003501.16670281
51Ovarian steroidogenesis_Homo sapiens_hsa049131.15992107
52Calcium signaling pathway_Homo sapiens_hsa040201.15492534
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15458195
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14453989
55Renin secretion_Homo sapiens_hsa049241.12618531
56Linoleic acid metabolism_Homo sapiens_hsa005911.09804163
57Selenocompound metabolism_Homo sapiens_hsa004501.03393654
58Fatty acid elongation_Homo sapiens_hsa000621.03222713
59Oxytocin signaling pathway_Homo sapiens_hsa049211.03126843
60Arginine biosynthesis_Homo sapiens_hsa002201.02767313
61Homologous recombination_Homo sapiens_hsa034401.01718708
62Sulfur relay system_Homo sapiens_hsa041221.01693341
63Proteasome_Homo sapiens_hsa030501.00779255
64Cholinergic synapse_Homo sapiens_hsa047250.99516542
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98840579
66Biosynthesis of amino acids_Homo sapiens_hsa012300.98608261
67Gastric acid secretion_Homo sapiens_hsa049710.98256114
68Long-term depression_Homo sapiens_hsa047300.97538856
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97345403
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97187584
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97099823
72Peroxisome_Homo sapiens_hsa041460.96497710
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96051505
74Carbon metabolism_Homo sapiens_hsa012000.94060638
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93816372
76Glucagon signaling pathway_Homo sapiens_hsa049220.91824551
77Melanogenesis_Homo sapiens_hsa049160.91714122
78Gap junction_Homo sapiens_hsa045400.90578134
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87674054
80Glutathione metabolism_Homo sapiens_hsa004800.87576870
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86334651
82Caffeine metabolism_Homo sapiens_hsa002320.86247457
83Oocyte meiosis_Homo sapiens_hsa041140.84809251
84Butanoate metabolism_Homo sapiens_hsa006500.82475177
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82424775
86Sulfur metabolism_Homo sapiens_hsa009200.80557678
87Fructose and mannose metabolism_Homo sapiens_hsa000510.79050423
88Mineral absorption_Homo sapiens_hsa049780.77340819
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.77169970
90Pancreatic secretion_Homo sapiens_hsa049720.75606901
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75190529
92Ribosome_Homo sapiens_hsa030100.72181578
93Fanconi anemia pathway_Homo sapiens_hsa034600.71157226
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70395432
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69631108
96Vitamin digestion and absorption_Homo sapiens_hsa049770.68963406
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68898863
98Sphingolipid metabolism_Homo sapiens_hsa006000.68244722
99GnRH signaling pathway_Homo sapiens_hsa049120.67678489
100Purine metabolism_Homo sapiens_hsa002300.66230067
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.65540805
102Thyroid hormone synthesis_Homo sapiens_hsa049180.65055969
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63404601
104Estrogen signaling pathway_Homo sapiens_hsa049150.63157975
105Basal transcription factors_Homo sapiens_hsa030220.62585793
106Fatty acid biosynthesis_Homo sapiens_hsa000610.62540276
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61801263
108Arginine and proline metabolism_Homo sapiens_hsa003300.60602031
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.59162049
110Pentose phosphate pathway_Homo sapiens_hsa000300.58642285
111Dilated cardiomyopathy_Homo sapiens_hsa054140.58409556
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57962642
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57928975
114PPAR signaling pathway_Homo sapiens_hsa033200.57323616
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51980965
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.51971612
117Bile secretion_Homo sapiens_hsa049760.51821487
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51786602
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51064079
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50358158
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50346218
122Lysine degradation_Homo sapiens_hsa003100.50071679
123Glycerolipid metabolism_Homo sapiens_hsa005610.49943283
124Metabolic pathways_Homo sapiens_hsa011000.48510161
125Tight junction_Homo sapiens_hsa045300.46968545
126Protein digestion and absorption_Homo sapiens_hsa049740.45924820
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45392391
128cAMP signaling pathway_Homo sapiens_hsa040240.44847465
129Circadian rhythm_Homo sapiens_hsa047100.44579758
130Starch and sucrose metabolism_Homo sapiens_hsa005000.43279853
131Wnt signaling pathway_Homo sapiens_hsa043100.42569432
132Hippo signaling pathway_Homo sapiens_hsa043900.42324403
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41416290
134Axon guidance_Homo sapiens_hsa043600.41043465
135Tryptophan metabolism_Homo sapiens_hsa003800.39278576
136RNA polymerase_Homo sapiens_hsa030200.38227271
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.37733279
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36885629
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36710763
140Fatty acid metabolism_Homo sapiens_hsa012120.35424046
141Phototransduction_Homo sapiens_hsa047440.34492348
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33343935

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