TPD52L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.97256867
2chromosome condensation (GO:0030261)8.85184962
3DNA packaging (GO:0006323)8.66410651
4spermatid development (GO:0007286)8.43194462
5single strand break repair (GO:0000012)8.17481239
6microtubule depolymerization (GO:0007019)7.95943022
7plasma membrane fusion (GO:0045026)7.91273968
8protein targeting to Golgi (GO:0000042)7.74941868
9protein polyglutamylation (GO:0018095)7.63221526
10establishment of protein localization to Golgi (GO:0072600)7.49567497
11spermatid nucleus differentiation (GO:0007289)7.47208541
12retrograde transport, vesicle recycling within Golgi (GO:0000301)7.22107620
13sperm-egg recognition (GO:0035036)7.17125424
14response to pheromone (GO:0019236)7.06340860
15microtubule polymerization or depolymerization (GO:0031109)7.06034375
16rRNA methylation (GO:0031167)7.03917097
17multicellular organism reproduction (GO:0032504)6.95626913
18axonemal dynein complex assembly (GO:0070286)6.80992236
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.70693697
20binding of sperm to zona pellucida (GO:0007339)6.48350055
21reproduction (GO:0000003)6.46497862
22spermatogenesis (GO:0007283)6.39033875
23centriole replication (GO:0007099)6.37780766
24male gamete generation (GO:0048232)6.36908913
25calcium ion-dependent exocytosis (GO:0017156)6.33491224
26negative regulation of inclusion body assembly (GO:0090084)6.32076600
27microtubule severing (GO:0051013)6.18654211
28phosphatidylethanolamine metabolic process (GO:0046337)6.17959759
29sexual reproduction (GO:0019953)6.02759595
30cilium or flagellum-dependent cell motility (GO:0001539)5.93260260
31cell-cell recognition (GO:0009988)5.90933692
32rRNA modification (GO:0000154)5.88290737
33gamete generation (GO:0007276)5.86047040
34centriole assembly (GO:0098534)5.64754293
35protein localization to Golgi apparatus (GO:0034067)5.58764636
36seminiferous tubule development (GO:0072520)5.55102841
37regulation of cilium movement (GO:0003352)5.42495611
38regulation of centriole replication (GO:0046599)5.25805877
39single fertilization (GO:0007338)5.18494721
40motile cilium assembly (GO:0044458)5.04456424
41RNA destabilization (GO:0050779)5.01567913
42germ cell development (GO:0007281)4.81984082
43positive regulation of Rab GTPase activity (GO:0032851)4.76696742
44regulation of Rab GTPase activity (GO:0032313)4.76696742
45multicellular organismal reproductive process (GO:0048609)4.69949171
46cellular ketone body metabolic process (GO:0046950)4.60108580
47epithelial cilium movement (GO:0003351)4.57769862
48fertilization (GO:0009566)4.53984753
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.51379170
50regulation of inclusion body assembly (GO:0090083)4.46600739
51cell wall macromolecule catabolic process (GO:0016998)4.45417249
52nucleus organization (GO:0006997)4.42350980
53cell wall macromolecule metabolic process (GO:0044036)4.31528967
54regulation of transcription involved in cell fate commitment (GO:0060850)4.28204935
55musculoskeletal movement (GO:0050881)4.06370649
56multicellular organismal movement (GO:0050879)4.06370649
57chromatin silencing (GO:0006342)4.04927383
58ketone body metabolic process (GO:1902224)4.04860555
59microtubule nucleation (GO:0007020)4.04840908
60cilium movement (GO:0003341)3.94478693
61glomerular visceral epithelial cell development (GO:0072015)3.89658922
62regulation of microtubule-based movement (GO:0060632)3.84365913
63organic cation transport (GO:0015695)3.78607515
64glomerular epithelial cell development (GO:0072310)3.69295686
65response to acidic pH (GO:0010447)3.57728316
66polyamine biosynthetic process (GO:0006596)3.52180961
67glycerol ether metabolic process (GO:0006662)3.43008855
68cellular response to pH (GO:0071467)3.36313663
69membrane protein intracellular domain proteolysis (GO:0031293)3.34850284
70protein-DNA complex disassembly (GO:0032986)3.30149481
71nucleosome disassembly (GO:0006337)3.30149481
72nuclear pore complex assembly (GO:0051292)3.29280462
73homeostasis of number of cells within a tissue (GO:0048873)3.25444441
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.24100450
75piRNA metabolic process (GO:0034587)3.17248543
76ether metabolic process (GO:0018904)3.15806005
77negative regulation of Rho protein signal transduction (GO:0035024)3.14812349
78multicellular organismal development (GO:0007275)3.14647258
79male meiosis I (GO:0007141)3.12449255
80coenzyme catabolic process (GO:0009109)3.10709904
81histone H3-K9 demethylation (GO:0033169)3.08225234
82regulation of interleukin-13 production (GO:0032656)3.06639978
83ventricular system development (GO:0021591)3.04792967
84regulation of phosphoprotein phosphatase activity (GO:0043666)3.04740743
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02610645
86male meiosis (GO:0007140)3.02308142
87cerebral cortex neuron differentiation (GO:0021895)3.01158935
88protein depolymerization (GO:0051261)2.98929517
89intra-Golgi vesicle-mediated transport (GO:0006891)2.92848696
90peptidyl-threonine dephosphorylation (GO:0035970)2.90275545
91positive regulation of guanylate cyclase activity (GO:0031284)2.89845152
92Golgi to endosome transport (GO:0006895)2.88495234
93DNA methylation involved in gamete generation (GO:0043046)2.87709004
94RNA localization (GO:0006403)2.86624901
95cell recognition (GO:0008037)2.84659137
96regulation of T-helper 2 cell differentiation (GO:0045628)2.83103916
97receptor recycling (GO:0001881)2.79164807
98sperm motility (GO:0030317)12.2716625
99acrosome reaction (GO:0007340)11.4858016
100fusion of sperm to egg plasma membrane (GO:0007342)10.4421413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.19302624
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04516521
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.44407358
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79907834
5EZH2_22144423_ChIP-Seq_EOC_Human2.63352206
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52299236
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52299236
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43952719
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.27139667
10CBP_20019798_ChIP-Seq_JUKART_Human2.27139667
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19580521
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19179597
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.14588050
14FUS_26573619_Chip-Seq_HEK293_Human2.10305503
15DROSHA_22980978_ChIP-Seq_HELA_Human1.92381737
16RAC3_21632823_ChIP-Seq_H3396_Human1.86599919
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.73353878
18NANOG_20526341_ChIP-Seq_ESCs_Human1.70538234
19* ERA_21632823_ChIP-Seq_H3396_Human1.67983497
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67796899
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.66190871
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.65487107
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64471240
24CTCF_27219007_Chip-Seq_Bcells_Human1.63100842
25ER_23166858_ChIP-Seq_MCF-7_Human1.62214271
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61666518
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61416760
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59529544
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.57103675
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.53616680
31MYC_19829295_ChIP-Seq_ESCs_Human1.51690264
32TAF2_19829295_ChIP-Seq_ESCs_Human1.51096168
33AR_25329375_ChIP-Seq_VCAP_Human1.50464493
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49758371
35BCL6_27268052_Chip-Seq_Bcells_Human1.46123084
36SMC4_20622854_ChIP-Seq_HELA_Human1.44539768
37OCT4_20526341_ChIP-Seq_ESCs_Human1.44364566
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.42810249
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40709222
40CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40315682
41RBPJ_21746931_ChIP-Seq_IB4_Human1.40219482
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38757577
43ERG_20517297_ChIP-Seq_VCAP_Human1.38626861
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.38211670
45BCOR_27268052_Chip-Seq_Bcells_Human1.36999398
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36277023
47CTCF_20526341_ChIP-Seq_ESCs_Human1.35062018
48ETV1_20927104_ChIP-Seq_GIST48_Human1.34364668
49E2F1_20622854_ChIP-Seq_HELA_Human1.33653305
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33549124
51PHF8_20622854_ChIP-Seq_HELA_Human1.33157523
52TP53_18474530_ChIP-ChIP_U2OS_Human1.32604770
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.32384050
54P68_20966046_ChIP-Seq_HELA_Human1.32089905
55TP63_22573176_ChIP-Seq_HFKS_Human1.31335260
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29044645
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29019666
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.26367251
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26005092
60NFYB_21822215_ChIP-Seq_K562_Human1.24661506
61* P300_19829295_ChIP-Seq_ESCs_Human1.23704024
62TBL1_22424771_ChIP-Seq_293T_Human1.22801325
63TAF15_26573619_Chip-Seq_HEK293_Human1.22703644
64CEBPB_22108803_ChIP-Seq_LS180_Human1.22691683
65P300_27268052_Chip-Seq_Bcells_Human1.19801302
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.18747048
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18314027
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18236968
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16784171
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.16384410
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15951401
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.14918405
73PHF8_20622853_ChIP-Seq_HELA_Human1.14804014
74P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.14480274
75STAT3_23295773_ChIP-Seq_U87_Human1.14254384
76SMAD4_21799915_ChIP-Seq_A2780_Human1.13558391
77RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13470365
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12428637
79* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11804037
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11612353
81LXR_22292898_ChIP-Seq_THP-1_Human1.10913525
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10680851
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10627570
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.10441331
85RUNX2_22187159_ChIP-Seq_PCA_Human1.09385848
86ZNF274_21170338_ChIP-Seq_K562_Hela1.09188472
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.08647769
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08133862
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06756790
90NFYA_21822215_ChIP-Seq_K562_Human1.04617975
91NANOG_19829295_ChIP-Seq_ESCs_Human1.04545713
92SOX2_19829295_ChIP-Seq_ESCs_Human1.04545713
93SMRT_27268052_Chip-Seq_Bcells_Human1.04008257
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.03496258
95OCT1_27270436_Chip-Seq_PROSTATE_Human1.03276377
96P53_21459846_ChIP-Seq_SAOS-2_Human1.03034515
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.02700461
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02163005
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01601791
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.01131504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.43944501
2MP0003878_abnormal_ear_physiology5.43944501
3MP0005670_abnormal_white_adipose4.80421066
4MP0003698_abnormal_male_reproductive4.58226764
5MP0001929_abnormal_gametogenesis4.05360604
6MP0001348_abnormal_lacrimal_gland3.04835492
7MP0002161_abnormal_fertility/fecundity2.54936890
8MP0003646_muscle_fatigue2.23169149
9MP0003718_maternal_effect2.21642382
10MP0000678_abnormal_parathyroid_gland2.20108680
11MP0002210_abnormal_sex_determination2.02904387
12MP0005410_abnormal_fertilization12.0690808
13MP0001485_abnormal_pinna_reflex1.81723912
14MP0005451_abnormal_body_composition1.75253370
15MP0001145_abnormal_male_reproductive1.61996521
16MP0001486_abnormal_startle_reflex1.61131041
17MP0002132_abnormal_respiratory_system1.60889163
18MP0003879_abnormal_hair_cell1.54687017
19MP0000653_abnormal_sex_gland1.52102093
20MP0005379_endocrine/exocrine_gland_phen1.49645785
21MP0005310_abnormal_salivary_gland1.48796935
22MP0005423_abnormal_somatic_nervous1.47925864
23MP0003011_delayed_dark_adaptation1.45200695
24MP0002735_abnormal_chemical_nociception1.36197688
25MP0001968_abnormal_touch/_nociception1.34238100
26MP0002234_abnormal_pharynx_morphology1.33831152
27MP0004859_abnormal_synaptic_plasticity1.29588317
28MP0004742_abnormal_vestibular_system1.28157198
29MP0002282_abnormal_trachea_morphology1.26393901
30MP0002249_abnormal_larynx_morphology1.24566882
31MP0002822_catalepsy1.16524101
32MP0008877_abnormal_DNA_methylation1.16140723
33MP0001963_abnormal_hearing_physiology1.15553467
34MP0000534_abnormal_ureter_morphology1.12522250
35MP0001765_abnormal_ion_homeostasis1.11880640
36MP0002138_abnormal_hepatobiliary_system1.08548427
37MP0009053_abnormal_anal_canal1.07883642
38MP0009115_abnormal_fat_cell1.05363272
39MP0005395_other_phenotype1.03372904
40MP0005666_abnormal_adipose_tissue1.00355161
41MP0005551_abnormal_eye_electrophysiolog0.95058622
42MP0000026_abnormal_inner_ear0.92538624
43MP0004510_myositis0.89557814
44MP0002127_abnormal_cardiovascular_syste0.86969528
45MP0002229_neurodegeneration0.85183849
46MP0009697_abnormal_copulation0.84821996
47MP0002067_abnormal_sensory_capabilities0.84789576
48MP0000955_abnormal_spinal_cord0.82781953
49MP0002557_abnormal_social/conspecific_i0.81431769
50MP0005248_abnormal_Harderian_gland0.77156846
51MP0001666_abnormal_nutrient_absorption0.75702792
52MP0005253_abnormal_eye_physiology0.75347166
53MP0008569_lethality_at_weaning0.70138498
54MP0002733_abnormal_thermal_nociception0.69230608
55MP0008995_early_reproductive_senescence0.69165758
56MP0005375_adipose_tissue_phenotype0.68237686
57MP0001501_abnormal_sleep_pattern0.67779088
58MP0004085_abnormal_heartbeat0.64050783
59MP0001905_abnormal_dopamine_level0.63629802
60MP0005647_abnormal_sex_gland0.63096305
61MP0002572_abnormal_emotion/affect_behav0.62011706
62MP0001440_abnormal_grooming_behavior0.61269499
63MP0000049_abnormal_middle_ear0.60914520
64MP0000681_abnormal_thyroid_gland0.60494619
65MP0002272_abnormal_nervous_system0.59416172
66MP0001986_abnormal_taste_sensitivity0.58633057
67MP0005167_abnormal_blood-brain_barrier0.58006746
68MP0009745_abnormal_behavioral_response0.57236144
69MP0005636_abnormal_mineral_homeostasis0.57144957
70MP0005083_abnormal_biliary_tract0.56531524
71MP0010329_abnormal_lipoprotein_level0.56395620
72MP0004484_altered_response_of0.55283213
73MP0002734_abnormal_mechanical_nocicepti0.53241339
74MP0001984_abnormal_olfaction0.52620278
75MP0004036_abnormal_muscle_relaxation0.50075395
76MP0004233_abnormal_muscle_weight0.49333180
77MP0001970_abnormal_pain_threshold0.47850943
78MP0000230_abnormal_systemic_arterial0.47594086
79MP0003077_abnormal_cell_cycle0.46393966
80MP0003119_abnormal_digestive_system0.44364132
81MP0001879_abnormal_lymphatic_vessel0.43803074
82MP0003631_nervous_system_phenotype0.43533964
83MP0000470_abnormal_stomach_morphology0.43094827
84MP0003699_abnormal_female_reproductive0.42930503
85MP0002928_abnormal_bile_duct0.42256444
86MP0005645_abnormal_hypothalamus_physiol0.41819697
87MP0005535_abnormal_body_temperature0.41294344
88MP0003959_abnormal_lean_body0.39697072
89MP0005367_renal/urinary_system_phenotyp0.39584767
90MP0000516_abnormal_urinary_system0.39584767
91MP0003633_abnormal_nervous_system0.38971246
92MP0001270_distended_abdomen0.38932858
93MP0000003_abnormal_adipose_tissue0.38386236
94MP0003137_abnormal_impulse_conducting0.38380937
95MP0003635_abnormal_synaptic_transmissio0.38253769
96MP0004084_abnormal_cardiac_muscle0.37813386
97MP0008961_abnormal_basal_metabolism0.37754858
98MP0005397_hematopoietic_system_phenotyp0.35856987
99MP0001545_abnormal_hematopoietic_system0.35856987
100MP0003936_abnormal_reproductive_system0.34720669

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.32508081
2Tubulointerstitial nephritis (HP:0001970)6.36232177
3Absent/shortened dynein arms (HP:0200106)6.11236701
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.11236701
5Chronic hepatic failure (HP:0100626)5.90750000
6Asymmetric septal hypertrophy (HP:0001670)5.43576391
7Abnormal respiratory motile cilium morphology (HP:0005938)5.10590972
8Abnormal respiratory epithelium morphology (HP:0012253)5.10590972
9Resting tremor (HP:0002322)4.74889282
10Hyperkalemia (HP:0002153)4.73261049
11Attenuation of retinal blood vessels (HP:0007843)4.66488551
12Male infertility (HP:0003251)4.60328894
13Abnormal ciliary motility (HP:0012262)4.57444908
14Abnormal respiratory motile cilium physiology (HP:0012261)4.57236016
15Bony spicule pigmentary retinopathy (HP:0007737)4.55963427
16Cone-rod dystrophy (HP:0000548)4.41966082
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.36031913
18Abnormality of macular pigmentation (HP:0008002)4.35238217
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.27323357
20Infertility (HP:0000789)4.22483251
21Nasal polyposis (HP:0100582)4.19295188
22Hypoalphalipoproteinemia (HP:0003233)3.76884744
23Bell-shaped thorax (HP:0001591)3.65302808
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.65213372
25Hypoplasia of the thymus (HP:0000778)3.58935762
26Facial shape deformation (HP:0011334)3.58068669
27Potter facies (HP:0002009)3.58068669
28Impulsivity (HP:0100710)3.53986294
29Progressive sensorineural hearing impairment (HP:0000408)3.52259773
30Menstrual irregularities (HP:0000858)3.45468562
31Abnormality of the nasal mucosa (HP:0000433)3.40003872
32Postural instability (HP:0002172)3.31553961
33Renovascular hypertension (HP:0100817)3.30702470
34Abnormal rod and cone electroretinograms (HP:0008323)3.25243343
35Amelogenesis imperfecta (HP:0000705)3.18528848
36Truncal obesity (HP:0001956)3.13640276
37Abnormal spermatogenesis (HP:0008669)3.09164036
38Abnormality of dental color (HP:0011073)3.01169513
39Insulin-resistant diabetes mellitus (HP:0000831)2.96305205
40Progressive cerebellar ataxia (HP:0002073)2.95828988
41Tubulointerstitial abnormality (HP:0001969)2.91310356
42Hypoplastic ischia (HP:0003175)2.89838386
43Nephronophthisis (HP:0000090)2.86089790
44Portal hypertension (HP:0001409)2.83336629
45Enlarged epiphyses (HP:0010580)2.78446215
46Stage 5 chronic kidney disease (HP:0003774)2.74752865
47Azoospermia (HP:0000027)2.73212393
48Rhinitis (HP:0012384)2.72302650
49Abnormality of the ischium (HP:0003174)2.64269836
50Abnormal urine output (HP:0012590)2.60379560
51Abnormality of the hepatic vasculature (HP:0006707)2.60298520
52Abnormality of potassium homeostasis (HP:0011042)2.55223268
53Abnormality of the aortic arch (HP:0012303)2.50193976
54Abnormality of the renal medulla (HP:0100957)2.44722889
55Generalized aminoaciduria (HP:0002909)2.40255141
56Osteomalacia (HP:0002749)2.38056154
57Abnormal drinking behavior (HP:0030082)2.37637880
58Polydipsia (HP:0001959)2.37637880
59Increased purine levels (HP:0004368)2.37322694
60Hyperuricemia (HP:0002149)2.37322694
61Unilateral renal agenesis (HP:0000122)2.36195587
62Abnormality of the costochondral junction (HP:0000919)2.33671044
63Abnormality of renal excretion (HP:0011036)2.25735284
64Chronic bronchitis (HP:0004469)2.25130727
65Subcapsular cataract (HP:0000523)2.23644840
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22211509
67Renal dysplasia (HP:0000110)2.20615167
68Intellectual disability, moderate (HP:0002342)2.16261212
69Progressive hearing impairment (HP:0001730)2.15867261
70Hypophosphatemic rickets (HP:0004912)2.14422932
71Polyuria (HP:0000103)2.09701801
72Ventricular tachycardia (HP:0004756)2.07279368
73Myokymia (HP:0002411)2.02526452
74Congenital malformation of the right heart (HP:0011723)2.02509952
75Double outlet right ventricle (HP:0001719)2.02509952
76Bronchiectasis (HP:0002110)1.99431276
77Recurrent pneumonia (HP:0006532)1.95815505
78Flattened epiphyses (HP:0003071)1.94603651
79Focal segmental glomerulosclerosis (HP:0000097)1.94453010
80Optic nerve hypoplasia (HP:0000609)1.91446251
81Hypolipoproteinemia (HP:0010981)1.89756868
82Upper limb muscle weakness (HP:0003484)1.87112443
83Decreased central vision (HP:0007663)1.86471142
84Congenital sensorineural hearing impairment (HP:0008527)1.84963264
85Bradycardia (HP:0001662)1.83872255
86Widely patent fontanelles and sutures (HP:0004492)1.81789649
87Hyponatremia (HP:0002902)1.78622289
88Hypergonadotropic hypogonadism (HP:0000815)1.74827749
89Photophobia (HP:0000613)1.72110842
90Abnormality of the parathyroid morphology (HP:0011766)1.71857949
91Insulin resistance (HP:0000855)1.70557148
92Epiphyseal dysplasia (HP:0002656)1.70087480
93Abnormality of chloride homeostasis (HP:0011422)1.68079365
94Tubular atrophy (HP:0000092)1.65409098
95Sandal gap (HP:0001852)1.65315210
96Abnormality of the epiphysis of the femoral head (HP:0010574)1.64265764
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63285099
98Renal Fanconi syndrome (HP:0001994)1.63148169
99Occipital encephalocele (HP:0002085)1.61824832
100Atonic seizures (HP:0010819)1.61727066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.30298947
2TESK14.88419309
3INSRR4.42482331
4BRD43.79848481
5PNCK3.56823640
6DDR23.49815311
7PLK23.49222800
8STK383.17536056
9MAP4K22.70224977
10CAMK1G2.52641998
11PRKD32.50354297
12STK38L2.23655601
13PIK3CG2.17030354
14MAPK152.01786048
15MST1R1.67759579
16PDPK11.63208754
17PDK11.58723048
18NEK61.48083478
19TYRO31.43818377
20CDK121.42673733
21WNK11.25380024
22AKT31.17598849
23PTK2B1.14202196
24DYRK1B1.14102717
25CDK71.06171092
26CAMK1D0.86886169
27SIK20.81723944
28BRAF0.81127665
29MAP3K90.79458130
30MAP3K110.78473406
31KSR20.72110946
32PINK10.68968303
33PRKG20.65074629
34PRKG10.63981915
35LATS20.63300037
36CASK0.61928920
37RIPK40.59022818
38RPS6KA20.57424306
39WNK40.56429708
40SGK2230.56036469
41SGK4940.56036469
42CAMK10.55567541
43TIE10.55318732
44STK390.53972266
45MAP2K20.51464878
46RPS6KA10.51054916
47CDK30.49575572
48MARK10.48540449
49PRKAA20.46791288
50MAP3K20.45101514
51FRK0.44357261
52ROCK10.43136939
53BMPR1B0.42383919
54UHMK10.42008319
55CDK20.41302041
56GSK3B0.41215588
57ICK0.40828072
58MAPK10.39317629
59OXSR10.38878893
60CDK10.38561615
61ADRBK20.37669698
62MAP3K80.36152816
63PRKCG0.35841724
64SGK10.32878662
65NTRK30.32649357
66CAMK40.32333944
67LATS10.32086464
68MTOR0.31567370
69MAPK80.31373596
70MAP3K10.30816683
71PRKCZ0.29480020
72MAP3K40.28351153
73SGK20.28306987
74MET0.27990176
75RPS6KL10.27011575
76RPS6KC10.27011575
77RPS6KA60.26955883
78BRSK10.26305473
79NEK20.24662629
80MAP3K130.23871836
81PRKCB0.23768635
82DYRK30.23195228
83CDK190.22767402
84CHEK10.22697355
85ZAK0.21852391
86MAPK140.21263437
87ARAF0.19283052
88MAPK100.18237092
89CDK40.17699696
90PKN10.17527756
91JAK30.17252101
92MUSK0.16192579
93MAPK110.15253626
94PRKCE0.15220039
95AKT10.14376570
96MARK20.14156696
97BRSK20.13414471
98TLK10.12136896
99BLK0.12082620
100TESK20.11646745

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.37026576
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.38971768
3Olfactory transduction_Homo sapiens_hsa047403.80039202
4Butanoate metabolism_Homo sapiens_hsa006502.34921431
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.13154555
6Fatty acid degradation_Homo sapiens_hsa000712.03057594
7Dorso-ventral axis formation_Homo sapiens_hsa043201.94240282
8Taste transduction_Homo sapiens_hsa047421.85254683
9Fatty acid metabolism_Homo sapiens_hsa012121.81194345
10RNA transport_Homo sapiens_hsa030131.76223543
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63405650
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62050792
13Type II diabetes mellitus_Homo sapiens_hsa049301.58651262
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52079702
15Phenylalanine metabolism_Homo sapiens_hsa003601.41582875
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.39770322
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39207441
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38693287
19Type I diabetes mellitus_Homo sapiens_hsa049401.21849352
20Phototransduction_Homo sapiens_hsa047441.19895594
21PPAR signaling pathway_Homo sapiens_hsa033201.16234879
22Antigen processing and presentation_Homo sapiens_hsa046121.13248021
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12961046
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10490789
25ABC transporters_Homo sapiens_hsa020101.10292051
26Autoimmune thyroid disease_Homo sapiens_hsa053201.09946379
27Allograft rejection_Homo sapiens_hsa053301.08693660
28Morphine addiction_Homo sapiens_hsa050321.08388875
29Nicotine addiction_Homo sapiens_hsa050331.08159408
30Calcium signaling pathway_Homo sapiens_hsa040201.05532024
31Salivary secretion_Homo sapiens_hsa049701.01535426
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.98748299
33Protein digestion and absorption_Homo sapiens_hsa049740.97733756
34Graft-versus-host disease_Homo sapiens_hsa053320.96222182
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91695757
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90842157
37Circadian entrainment_Homo sapiens_hsa047130.90403984
38Endocytosis_Homo sapiens_hsa041440.89428410
39Inositol phosphate metabolism_Homo sapiens_hsa005620.89036884
40Arginine and proline metabolism_Homo sapiens_hsa003300.88362436
41Arginine biosynthesis_Homo sapiens_hsa002200.87257779
42Synaptic vesicle cycle_Homo sapiens_hsa047210.86108557
43Glycerolipid metabolism_Homo sapiens_hsa005610.84562414
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.82363390
45cAMP signaling pathway_Homo sapiens_hsa040240.82120012
46Hedgehog signaling pathway_Homo sapiens_hsa043400.80440719
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78315992
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78222536
49Oocyte meiosis_Homo sapiens_hsa041140.76243591
50Viral myocarditis_Homo sapiens_hsa054160.75553531
51Fat digestion and absorption_Homo sapiens_hsa049750.74879445
52Glutamatergic synapse_Homo sapiens_hsa047240.73550099
53Influenza A_Homo sapiens_hsa051640.71986890
54Cardiac muscle contraction_Homo sapiens_hsa042600.71353172
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70108844
56Estrogen signaling pathway_Homo sapiens_hsa049150.65961160
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62886286
58Nitrogen metabolism_Homo sapiens_hsa009100.62833595
59Gastric acid secretion_Homo sapiens_hsa049710.60722431
60Renin-angiotensin system_Homo sapiens_hsa046140.59108754
61Serotonergic synapse_Homo sapiens_hsa047260.58533321
62Tyrosine metabolism_Homo sapiens_hsa003500.56933446
63VEGF signaling pathway_Homo sapiens_hsa043700.56176548
64Renin secretion_Homo sapiens_hsa049240.54430954
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53653642
66Retinol metabolism_Homo sapiens_hsa008300.52935459
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52369416
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51059712
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.51035442
70Bile secretion_Homo sapiens_hsa049760.50633891
71Insulin secretion_Homo sapiens_hsa049110.50237854
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50007223
73Pancreatic secretion_Homo sapiens_hsa049720.49289410
74MAPK signaling pathway_Homo sapiens_hsa040100.49041757
75Cholinergic synapse_Homo sapiens_hsa047250.48099307
76Selenocompound metabolism_Homo sapiens_hsa004500.45587514
77GABAergic synapse_Homo sapiens_hsa047270.45020992
78Purine metabolism_Homo sapiens_hsa002300.44913996
79Fanconi anemia pathway_Homo sapiens_hsa034600.44004062
80Tight junction_Homo sapiens_hsa045300.37283284
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36450930
82Long-term potentiation_Homo sapiens_hsa047200.36028191
83Oxytocin signaling pathway_Homo sapiens_hsa049210.32723608
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31262869
85Acute myeloid leukemia_Homo sapiens_hsa052210.30558179
86ECM-receptor interaction_Homo sapiens_hsa045120.30509577
87Prolactin signaling pathway_Homo sapiens_hsa049170.29817631
88Biosynthesis of amino acids_Homo sapiens_hsa012300.28404757
89Amphetamine addiction_Homo sapiens_hsa050310.27650346
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.26503677
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26155283
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24843545
93mRNA surveillance pathway_Homo sapiens_hsa030150.24688067
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.24152927
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20971110
96Linoleic acid metabolism_Homo sapiens_hsa005910.20487322
97Basal transcription factors_Homo sapiens_hsa030220.19235344
98Sulfur relay system_Homo sapiens_hsa041220.14929478
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14177648
100Huntingtons disease_Homo sapiens_hsa050160.13359601

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