TPGS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.47172639
2ribosomal small subunit assembly (GO:0000028)5.31205709
3proteasome assembly (GO:0043248)5.17142552
4viral transcription (GO:0019083)5.13688704
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93353924
6translational termination (GO:0006415)4.91683463
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.84404805
8estrogen biosynthetic process (GO:0006703)4.82317151
9ATP synthesis coupled proton transport (GO:0015986)4.61075709
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.61075709
11translational elongation (GO:0006414)4.52707881
12regulation of mitochondrial translation (GO:0070129)4.45164969
13ribosomal small subunit biogenesis (GO:0042274)4.38534018
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.36493420
15cotranslational protein targeting to membrane (GO:0006613)4.28004723
16protein targeting to ER (GO:0045047)4.24713100
17protein localization to endoplasmic reticulum (GO:0070972)4.20460706
18protein complex biogenesis (GO:0070271)4.18346462
19protein targeting to mitochondrion (GO:0006626)4.08759012
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06192825
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.05966079
22cellular protein complex disassembly (GO:0043624)4.05617992
23translational initiation (GO:0006413)4.02300976
24mitochondrial respiratory chain complex assembly (GO:0033108)4.01663145
25establishment of protein localization to mitochondrion (GO:0072655)4.00268170
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.98107781
27NADH dehydrogenase complex assembly (GO:0010257)3.98107781
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98107781
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.96589592
30viral life cycle (GO:0019058)3.91477745
31base-excision repair, AP site formation (GO:0006285)3.89211448
32GDP-mannose metabolic process (GO:0019673)3.86921673
33chaperone-mediated protein transport (GO:0072321)3.85544258
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.80030982
35protein maturation by protein folding (GO:0022417)3.79129678
36translation (GO:0006412)3.77938137
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77712883
38negative regulation of ligase activity (GO:0051352)3.77712883
39formation of translation preinitiation complex (GO:0001731)3.71118173
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69843944
41maturation of SSU-rRNA (GO:0030490)3.69743748
42regulation of cellular amino acid metabolic process (GO:0006521)3.68330683
43respiratory chain complex IV assembly (GO:0008535)3.66362334
44ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.65960567
45ribosomal large subunit biogenesis (GO:0042273)3.62008825
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.60920120
47deoxyribose phosphate biosynthetic process (GO:0046385)3.60920120
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58288197
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56962680
50oxidative phosphorylation (GO:0006119)3.56449918
51protein complex disassembly (GO:0043241)3.55515614
52tRNA methylation (GO:0030488)3.54706551
53GMP metabolic process (GO:0046037)3.53509155
54respiratory electron transport chain (GO:0022904)3.52790379
55electron transport chain (GO:0022900)3.51981952
56macromolecular complex disassembly (GO:0032984)3.50840491
57negative regulation of microtubule polymerization (GO:0031115)3.50626026
58iron-sulfur cluster assembly (GO:0016226)3.50584699
59metallo-sulfur cluster assembly (GO:0031163)3.50584699
60sequestering of actin monomers (GO:0042989)3.50293148
61protein insertion into membrane (GO:0051205)3.48848501
62protein localization to mitochondrion (GO:0070585)3.48365762
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47117973
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46107713
65cytochrome complex assembly (GO:0017004)3.39626782
66NIK/NF-kappaB signaling (GO:0038061)3.38967060
67positive regulation of prostaglandin secretion (GO:0032308)3.37173293
68phosphatidylglycerol biosynthetic process (GO:0006655)3.36345360
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35425614
70UV protection (GO:0009650)3.34035111
71de novo protein folding (GO:0006458)3.30551511
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.29105320
73termination of RNA polymerase III transcription (GO:0006386)3.29105320
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27869441
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27869441
76de novo posttranslational protein folding (GO:0051084)3.25878656
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24309113
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24309113
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24309113
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23041469
81pyrimidine nucleotide catabolic process (GO:0006244)3.22763970
82telomere maintenance via semi-conservative replication (GO:0032201)3.22490310
83DNA strand elongation involved in DNA replication (GO:0006271)3.20986308
84spliceosomal snRNP assembly (GO:0000387)3.17857554
85L-methionine salvage (GO:0071267)3.17831787
86L-methionine biosynthetic process (GO:0071265)3.17831787
87amino acid salvage (GO:0043102)3.17831787
88cellular component biogenesis (GO:0044085)3.15034593
89response to misfolded protein (GO:0051788)3.14049794
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.13039595
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13039595
92nucleoside salvage (GO:0043174)3.10292765
93deoxyribose phosphate catabolic process (GO:0046386)3.09328226
94positive thymic T cell selection (GO:0045059)3.08813173
95signal transduction involved in cell cycle checkpoint (GO:0072395)3.07276006
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06710180
97guanosine-containing compound biosynthetic process (GO:1901070)3.05035771
98positive regulation of B cell differentiation (GO:0045579)3.04160134
99pseudouridine synthesis (GO:0001522)3.01909614
100ribonucleoprotein complex biogenesis (GO:0022613)3.01876579
101positive regulation of ligase activity (GO:0051351)3.01106304
102response to peptidoglycan (GO:0032494)3.00442249
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98135410
104negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97527704
105protein targeting to membrane (GO:0006612)2.97344684
106deoxyribonucleotide catabolic process (GO:0009264)2.95873705
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95639676
108regulation of protein heterodimerization activity (GO:0043497)2.95613413
109DNA strand elongation (GO:0022616)2.95485429
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94831567
111negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.94723426
112deoxyribonucleotide biosynthetic process (GO:0009263)2.94110116
113protein deneddylation (GO:0000338)2.93812270
114anterograde synaptic vesicle transport (GO:0048490)2.92701069
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87893902
116purine deoxyribonucleotide catabolic process (GO:0009155)2.87385312
117response to pheromone (GO:0019236)2.86652795
118amino sugar catabolic process (GO:0046348)2.82899433
119GPI anchor biosynthetic process (GO:0006506)2.82082247
120immunoglobulin mediated immune response (GO:0016064)2.81588134
121positive regulation of lymphocyte apoptotic process (GO:0070230)2.80702952
122negative regulation of erythrocyte differentiation (GO:0045647)2.77831574
123cellular response to arsenic-containing substance (GO:0071243)2.77745578
124negative regulation of interleukin-12 production (GO:0032695)2.73917752
125positive regulation of fatty acid transport (GO:2000193)2.71313882
126positive regulation of icosanoid secretion (GO:0032305)2.67012956
127positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66378478
128regulation of B cell apoptotic process (GO:0002902)2.63343112
129regulation of T cell mediated cytotoxicity (GO:0001914)2.60963272
130positive regulation of protein deacetylation (GO:0090312)2.58947469
131positive regulation of histone deacetylation (GO:0031065)2.58889903
132ncRNA 3-end processing (GO:0043628)2.58515502
133opioid receptor signaling pathway (GO:0038003)2.57431448
134negative regulation of cAMP-mediated signaling (GO:0043951)2.56514846
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55632653
136negative regulation of granulocyte differentiation (GO:0030853)2.54067657
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53867919
138positive regulation of T cell apoptotic process (GO:0070234)2.53236758
139negative regulation of mast cell activation (GO:0033004)2.53106985
140regulation of natural killer cell mediated immunity (GO:0002715)2.53085237
141regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53085237
142regulation of mast cell degranulation (GO:0043304)2.52891036
143Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52886354
144response to protozoan (GO:0001562)2.52844506
145negative regulation of tumor necrosis factor production (GO:0032720)2.52209165
146positive regulation of mast cell degranulation (GO:0043306)2.51121691
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.51121691
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50009878
149negative regulation of cell killing (GO:0031342)2.50009878
150GPI anchor metabolic process (GO:0006505)2.48052869
151regulation of B cell receptor signaling pathway (GO:0050855)2.48016900
152lytic vacuole organization (GO:0080171)2.47655624
153lysosome organization (GO:0007040)2.47655624
154seminiferous tubule development (GO:0072520)2.45676514
155negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.43286875
156polyamine biosynthetic process (GO:0006596)2.43142874
157positive T cell selection (GO:0043368)2.41744939
158response to acidic pH (GO:0010447)2.40524472
159negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.39913734
160negative regulation of systemic arterial blood pressure (GO:0003085)2.39749870
161negative regulation of DNA-templated transcription, elongation (GO:0032785)2.39701298
162interleukin-1-mediated signaling pathway (GO:0070498)2.38571762
163regulation of leukocyte mediated cytotoxicity (GO:0001910)2.37979187
164positive regulation of mast cell activation (GO:0033005)2.37919645
165regulation of prostaglandin secretion (GO:0032306)2.37139188
1662-deoxyribonucleotide metabolic process (GO:0009394)2.36754099
167positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.35667026
168toxin transport (GO:1901998)2.34739288
169N-acetylneuraminate metabolic process (GO:0006054)2.33790480
170regulation of mast cell activation (GO:0033003)2.33781723
171phosphatidylethanolamine biosynthetic process (GO:0006646)2.33316705
172regulation of inflammatory response to antigenic stimulus (GO:0002861)2.32861269
173cytidine metabolic process (GO:0046087)2.32686582
174cytidine catabolic process (GO:0006216)2.32686582
175cytidine deamination (GO:0009972)2.32686582
176pentose metabolic process (GO:0019321)2.32383840
177regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.31934375
178regulation of mast cell activation involved in immune response (GO:0033006)2.31296123
179negative regulation of sodium ion transport (GO:0010766)2.30055647
180phosphatidylethanolamine metabolic process (GO:0046337)2.26407674
181phagosome maturation (GO:0090382)2.25898935
182negative regulation of phagocytosis (GO:0050765)2.25453157
183viral protein processing (GO:0019082)2.24894894
184defense response to protozoan (GO:0042832)2.24667750
185GTP biosynthetic process (GO:0006183)2.24211576
186energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.23132470
187ATP hydrolysis coupled proton transport (GO:0015991)2.23132470
188actin nucleation (GO:0045010)2.22471405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.39194846
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55330308
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.38609535
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25076507
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.23495927
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.23406864
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.14641729
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07010076
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.04228622
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99592852
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96840872
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88882300
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.78259042
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67381558
15XRN2_22483619_ChIP-Seq_HELA_Human2.52483606
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50113120
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46334473
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44075926
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36398926
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33269857
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29277557
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.28974087
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25273160
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21594318
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.18877811
26GABP_19822575_ChIP-Seq_HepG2_Human2.08097313
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07939320
28DCP1A_22483619_ChIP-Seq_HELA_Human2.05358709
29SRY_22984422_ChIP-ChIP_TESTIS_Rat2.00252588
30VDR_23849224_ChIP-Seq_CD4+_Human1.95523306
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90235153
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88606061
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87716698
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84133625
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83342497
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82141120
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.79625742
38TTF2_22483619_ChIP-Seq_HELA_Human1.78245805
39CTCF_18555785_ChIP-Seq_MESCs_Mouse1.77131530
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75000845
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74962505
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73905175
43FOXP3_21729870_ChIP-Seq_TREG_Human1.73174998
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72524877
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72246020
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.71826764
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.66443638
48VDR_24763502_ChIP-Seq_THP-1_Human1.66017027
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65847644
50E2F1_20622854_ChIP-Seq_HELA_Human1.63345325
51VDR_21846776_ChIP-Seq_THP-1_Human1.63286459
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60305436
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60296009
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58873378
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56736632
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51443964
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.50422066
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49827575
59LXR_22292898_ChIP-Seq_THP-1_Human1.49786445
60KDM2B_26808549_Chip-Seq_DND41_Human1.49020491
61UTX_26944678_Chip-Seq_JUKART_Human1.48901132
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47173994
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45695206
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45454764
65MAF_26560356_Chip-Seq_TH1_Human1.45255184
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43725328
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43572054
68SCL_19346495_ChIP-Seq_HPC-7_Human1.43513972
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39919892
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.38996830
71* CIITA_25753668_ChIP-Seq_RAJI_Human1.37683882
72P300_27268052_Chip-Seq_Bcells_Human1.36882304
73E2F7_22180533_ChIP-Seq_HELA_Human1.36110530
74SMC4_20622854_ChIP-Seq_HELA_Human1.35840073
75MYC_22102868_ChIP-Seq_BL_Human1.35824392
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35217671
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.34519164
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34500561
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32325974
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32219012
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32199796
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31574527
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31117993
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31101906
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30772906
86CTCF_27219007_Chip-Seq_Bcells_Human1.30573983
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29535868
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28936891
89BCL6_27268052_Chip-Seq_Bcells_Human1.27013635
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26753954
91RAC3_21632823_ChIP-Seq_H3396_Human1.26647866
92CTCF_21964334_Chip-Seq_Bcells_Human1.26147730
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24821414
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24319514
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23763564
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23684186
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22717092
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22710191
99ERA_21632823_ChIP-Seq_H3396_Human1.21143706
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.20607683
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19048224
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.18114877
103CTCF_26484167_Chip-Seq_Bcells_Mouse1.17966588
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17425194
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.16524405
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16503579
107RARB_24833708_ChIP-Seq_LIVER_Mouse1.16360997
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.16038994
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15792818
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14154604
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13893175
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13569646
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13234474
114P68_20966046_ChIP-Seq_HELA_Human1.12959701
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12179478
116STAT1_20625510_ChIP-Seq_HELA_Human1.11786175
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11730413
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10546769
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.10073741
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09557377
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09354732
122SPI1_23547873_ChIP-Seq_NB4_Human1.09335606
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09230860
124RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09216087
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08440894
126OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08155879
127HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08150839
128TAF2_19829295_ChIP-Seq_ESCs_Human1.07616614
129SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07205166
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06940717
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06764120
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05406947
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04826647
134ZNF263_19887448_ChIP-Seq_K562_Human1.04459608
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.04364013
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04155813
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02978699
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02900471
139SA1_27219007_Chip-Seq_Bcells_Human1.01342427
140SPI1_23127762_ChIP-Seq_K562_Human1.00939174
141BCOR_27268052_Chip-Seq_Bcells_Human1.00285636
142CTCF_20526341_ChIP-Seq_ESCs_Human1.00198536
143MAF_26560356_Chip-Seq_TH2_Human0.99726066
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98871387
145MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98844856
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98532279
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97936781
148RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97114917
149KDM5A_27292631_Chip-Seq_BREAST_Human0.96093555
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95829080
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95177935
152PHF8_20622854_ChIP-Seq_HELA_Human0.94776494
153GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93744197
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91659806
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90965983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.31600224
2MP0005058_abnormal_lysosome_morphology3.21351272
3MP0009840_abnormal_foam_cell3.16832719
4MP0009379_abnormal_foot_pigmentation3.14800574
5MP0003172_abnormal_lysosome_physiology3.00496384
6MP0002735_abnormal_chemical_nociception2.87623897
7MP0001968_abnormal_touch/_nociception2.76767150
8MP0002638_abnormal_pupillary_reflex2.74514125
9MP0005451_abnormal_body_composition2.71663432
10MP0003806_abnormal_nucleotide_metabolis2.67866758
11MP0004858_abnormal_nervous_system2.61834442
12MP0003436_decreased_susceptibility_to2.58211510
13MP0003303_peritoneal_inflammation2.56939253
14MP0003693_abnormal_embryo_hatching2.55648392
15MP0002148_abnormal_hypersensitivity_rea2.55533134
16MP0003123_paternal_imprinting2.40139008
17MP0005084_abnormal_gallbladder_morpholo2.31401370
18MP0003329_amyloid_beta_deposits2.29311294
19MP0004859_abnormal_synaptic_plasticity2.26143904
20MP0005075_abnormal_melanosome_morpholog2.23962753
21MP0002736_abnormal_nociception_after2.23582322
22MP0003787_abnormal_imprinting2.22636658
23MP0009278_abnormal_bone_marrow2.21618475
24MP0006276_abnormal_autonomic_nervous2.18846645
25MP0002733_abnormal_thermal_nociception2.17058045
26MP0001835_abnormal_antigen_presentation2.08658232
27MP0004142_abnormal_muscle_tone2.07815479
28MP0003724_increased_susceptibility_to2.06448833
29MP0001545_abnormal_hematopoietic_system2.04003555
30MP0005397_hematopoietic_system_phenotyp2.04003555
31MP0006082_CNS_inflammation2.03813269
32MP0006036_abnormal_mitochondrial_physio2.02389849
33MP0005000_abnormal_immune_tolerance1.98953080
34MP0002837_dystrophic_cardiac_calcinosis1.98107949
35MP0003646_muscle_fatigue1.95685202
36MP0002751_abnormal_autonomic_nervous1.91228870
37MP0005025_abnormal_response_to1.86351147
38MP0001790_abnormal_immune_system1.84114381
39MP0005387_immune_system_phenotype1.84114381
40MP0001984_abnormal_olfaction1.83331702
41MP0003880_abnormal_central_pattern1.83046219
42MP0000465_gastrointestinal_hemorrhage1.81363793
43MP0001970_abnormal_pain_threshold1.80990701
44MP0002723_abnormal_immune_serum1.80470712
45MP0002419_abnormal_innate_immunity1.79734857
46MP0002653_abnormal_ependyma_morphology1.77725425
47MP0000749_muscle_degeneration1.76454207
48MP0004957_abnormal_blastocyst_morpholog1.76029907
49MP0009764_decreased_sensitivity_to1.71472440
50MP0001800_abnormal_humoral_immune1.69989313
51MP0002272_abnormal_nervous_system1.69497475
52MP0003879_abnormal_hair_cell1.68418104
53MP0004133_heterotaxia1.68299884
54MP0004270_analgesia1.67902714
55MP0002420_abnormal_adaptive_immunity1.64763358
56MP0005310_abnormal_salivary_gland1.63214906
57MP0002452_abnormal_antigen_presenting1.60785911
58MP0003718_maternal_effect1.59438359
59MP0001819_abnormal_immune_cell1.59073161
60MP0000681_abnormal_thyroid_gland1.58556431
61MP0002734_abnormal_mechanical_nocicepti1.57651841
62MP0008932_abnormal_embryonic_tissue1.55534931
63MP0001529_abnormal_vocalization1.54544779
64MP0006035_abnormal_mitochondrial_morpho1.53709496
65MP0003656_abnormal_erythrocyte_physiolo1.51809226
66MP0003279_aneurysm1.50848760
67MP0001533_abnormal_skeleton_physiology1.49985855
68MP0002254_reproductive_system_inflammat1.44740911
69MP0008789_abnormal_olfactory_epithelium1.41000476
70MP0003866_abnormal_defecation1.40240435
71MP0001986_abnormal_taste_sensitivity1.38256564
72MP0002184_abnormal_innervation1.38141103
73MP0002138_abnormal_hepatobiliary_system1.37735850
74MP0004510_myositis1.36143669
75MP0003635_abnormal_synaptic_transmissio1.36115992
76MP0004147_increased_porphyrin_level1.34056456
77MP0000716_abnormal_immune_system1.33416730
78MP0002160_abnormal_reproductive_system1.32167173
79MP0002822_catalepsy1.31636673
80MP0005464_abnormal_platelet_physiology1.31494545
81MP0001873_stomach_inflammation1.29260905
82MP0000358_abnormal_cell_content/1.29025154
83MP0003075_altered_response_to1.28974623
84MP0005167_abnormal_blood-brain_barrier1.28193832
85MP0008469_abnormal_protein_level1.27752286
86MP0003122_maternal_imprinting1.27505141
87MP0005379_endocrine/exocrine_gland_phen1.27284567
88MP0002405_respiratory_system_inflammati1.27071191
89MP0005410_abnormal_fertilization1.24579415
90MP0001845_abnormal_inflammatory_respons1.24195045
91MP0002064_seizures1.23423625
92MP0004145_abnormal_muscle_electrophysio1.22837003
93MP0000685_abnormal_immune_system1.22376299
94MP0005670_abnormal_white_adipose1.17100591
95MP0008260_abnormal_autophagy1.16591393
96MP0008875_abnormal_xenobiotic_pharmacok1.14797827
97MP0004947_skin_inflammation1.14746998
98MP0001905_abnormal_dopamine_level1.14740053
99MP0000955_abnormal_spinal_cord1.14449221
100MP0005394_taste/olfaction_phenotype1.11636439
101MP0005499_abnormal_olfactory_system1.11636439
102MP0009333_abnormal_splenocyte_physiolog1.10725033
103MP0002429_abnormal_blood_cell1.10506330
104MP0005636_abnormal_mineral_homeostasis1.10460890
105MP0000604_amyloidosis1.09805433
106MP0004811_abnormal_neuron_physiology1.07613502
107MP0000343_altered_response_to1.05994797
108MP0008007_abnormal_cellular_replicative1.05805287
109MP0001919_abnormal_reproductive_system1.05303623
110MP0001663_abnormal_digestive_system1.03363340
111MP0002909_abnormal_adrenal_gland1.01589725
112MP0003077_abnormal_cell_cycle1.01339315
113MP0010030_abnormal_orbit_morphology1.01218515
114MP0002067_abnormal_sensory_capabilities0.99898887
115MP0002933_joint_inflammation0.99375917
116MP0001542_abnormal_bone_strength0.98101103
117MP0009745_abnormal_behavioral_response0.96939060
118MP0005083_abnormal_biliary_tract0.96471075
119MP0005551_abnormal_eye_electrophysiolog0.96372972
120MP0002876_abnormal_thyroid_physiology0.92416712
121MP0005165_increased_susceptibility_to0.91864779
122MP0000015_abnormal_ear_pigmentation0.90343205
123MP0008569_lethality_at_weaning0.88959252
124MP0002998_abnormal_bone_remodeling0.88647471
125MP0005390_skeleton_phenotype0.88433411
126MP0006072_abnormal_retinal_apoptosis0.88217819
127MP0002163_abnormal_gland_morphology0.87991270
128MP0005389_reproductive_system_phenotype0.85474888
129MP0009765_abnormal_xenobiotic_induced0.85427263
130MP0002089_abnormal_postnatal_growth/wei0.85209731
131MP0008872_abnormal_physiological_respon0.84270795
132MP0003111_abnormal_nucleus_morphology0.82415308
133MP0005671_abnormal_response_to0.81489412
134MP0004130_abnormal_muscle_cell0.80601439
135MP0002269_muscular_atrophy0.79785596
136MP0009785_altered_susceptibility_to0.78501504
137MP0003763_abnormal_thymus_physiology0.78350168
138MP0004381_abnormal_hair_follicle0.77188878
139MP0005535_abnormal_body_temperature0.76909214
140MP0005174_abnormal_tail_pigmentation0.76739137
141MP0003221_abnormal_cardiomyocyte_apopto0.76501490
142MP0003786_premature_aging0.76165721
143MP0002332_abnormal_exercise_endurance0.75909768
144MP0001188_hyperpigmentation0.75344998
145MP0003186_abnormal_redox_activity0.74380762
146MP0003191_abnormal_cellular_cholesterol0.74018537
147MP0002063_abnormal_learning/memory/cond0.73845155
148MP0005166_decreased_susceptibility_to0.73738889
149MP0002882_abnormal_neuron_morphology0.72733751
150MP0001501_abnormal_sleep_pattern0.72540654
151MP0000490_abnormal_crypts_of0.71540449
152MP0000313_abnormal_cell_death0.70893387
153MP0002396_abnormal_hematopoietic_system0.70589531
154MP0002722_abnormal_immune_system0.70287928
155MP0010155_abnormal_intestine_physiology0.70195042
156MP0009046_muscle_twitch0.69073483
157MP0001348_abnormal_lacrimal_gland0.68805774
158MP0002752_abnormal_somatic_nervous0.67462879
159MP0000689_abnormal_spleen_morphology0.66999133
160MP0001764_abnormal_homeostasis0.66211390
161MP0002066_abnormal_motor_capabilities/c0.65837102
162MP0003315_abnormal_perineum_morphology0.65362467
163MP0000747_muscle_weakness0.65292622
164MP0004233_abnormal_muscle_weight0.65278256
165MP0002398_abnormal_bone_marrow0.65056469
166MP0000703_abnormal_thymus_morphology0.64928916
167MP0005381_digestive/alimentary_phenotyp0.64803898
168MP0002693_abnormal_pancreas_physiology0.64180714
169MP0002229_neurodegeneration0.63690762
170MP0005423_abnormal_somatic_nervous0.63494095
171MP0003121_genomic_imprinting0.62944904

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.29543038
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.75230732
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.75230732
4Mitochondrial inheritance (HP:0001427)4.73822306
5Abnormality of cells of the erythroid lineage (HP:0012130)4.66299525
6Myokymia (HP:0002411)4.61990225
7Hepatic necrosis (HP:0002605)4.59476056
8Abnormal number of erythroid precursors (HP:0012131)4.39183576
9Abnormality of liposaccharide metabolism (HP:0010968)4.38464476
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.38464476
11Abnormality of glycolipid metabolism (HP:0010969)4.38464476
12Abnormal mitochondria in muscle tissue (HP:0008316)4.16020167
13Acute necrotizing encephalopathy (HP:0006965)4.15175458
14Increased CSF lactate (HP:0002490)4.03059680
15Cerebral hypomyelination (HP:0006808)3.78993731
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.71909161
17Increased cerebral lipofuscin (HP:0011813)3.63418143
18Vacuolated lymphocytes (HP:0001922)3.60513063
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.52533958
20Emotional lability (HP:0000712)3.50417961
21Abnormality of polysaccharide metabolism (HP:0011012)3.49971410
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.49971410
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.49971410
24Increased intramyocellular lipid droplets (HP:0012240)3.37459514
25Acute encephalopathy (HP:0006846)3.34097316
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33862227
27Increased serum lactate (HP:0002151)3.32253041
28Delusions (HP:0000746)3.27520335
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.27439123
30Dysostosis multiplex (HP:0000943)3.26394844
31Aplastic anemia (HP:0001915)3.24702218
32Hyperthyroidism (HP:0000836)3.11783336
33Congenital stationary night blindness (HP:0007642)3.10361851
34Macrocytic anemia (HP:0001972)3.09403848
35Increased muscle lipid content (HP:0009058)3.06375480
36Increased hepatocellular lipid droplets (HP:0006565)3.04613976
37Mucopolysacchariduria (HP:0008155)3.03357316
38Urinary glycosaminoglycan excretion (HP:0003541)3.03357316
39Lactic acidosis (HP:0003128)3.01474511
40Mediastinal lymphadenopathy (HP:0100721)2.99465606
41Progressive macrocephaly (HP:0004481)2.98991484
42Visual hallucinations (HP:0002367)2.96113701
43Reticulocytopenia (HP:0001896)2.90331628
44Lipid accumulation in hepatocytes (HP:0006561)2.89982840
45Abnormality of macular pigmentation (HP:0008002)2.88072083
46Abnormality of macrophages (HP:0004311)2.86154620
47Chronic obstructive pulmonary disease (HP:0006510)2.84803878
48Obstructive lung disease (HP:0006536)2.84803878
49Respiratory failure (HP:0002878)2.83113402
50Unsteady gait (HP:0002317)2.80260899
51Microretrognathia (HP:0000308)2.75838498
52Severe visual impairment (HP:0001141)2.73569242
53Prolonged neonatal jaundice (HP:0006579)2.66035722
54Type I transferrin isoform profile (HP:0003642)2.64688269
55CNS demyelination (HP:0007305)2.63468854
56Exercise intolerance (HP:0003546)2.61198130
57Split foot (HP:0001839)2.57806097
58Retinal atrophy (HP:0001105)2.53884480
59Attenuation of retinal blood vessels (HP:0007843)2.50673921
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49652331
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48350674
62Hypercortisolism (HP:0001578)2.47950964
63Exertional dyspnea (HP:0002875)2.47792706
64Renal Fanconi syndrome (HP:0001994)2.44500972
65Elevated erythrocyte sedimentation rate (HP:0003565)2.42050074
66Ragged-red muscle fibers (HP:0003200)2.37444197
67Pallor (HP:0000980)2.36244060
68Protruding tongue (HP:0010808)2.35480499
69Abnormality of magnesium homeostasis (HP:0004921)2.33549334
70Thoracic kyphosis (HP:0002942)2.32749087
71Pustule (HP:0200039)2.32013153
72Axonal loss (HP:0003447)2.31178736
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30762487
74Mesangial abnormality (HP:0001966)2.28990654
75Polyphagia (HP:0002591)2.28486807
76Recurrent cutaneous fungal infections (HP:0011370)2.26678510
77Chronic mucocutaneous candidiasis (HP:0002728)2.26678510
78Abnormality of alanine metabolism (HP:0010916)2.26537098
79Hyperalaninemia (HP:0003348)2.26537098
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26537098
81Purpura (HP:0000979)2.25718009
82Macular degeneration (HP:0000608)2.25530235
83Poor suck (HP:0002033)2.22701625
84Recurrent fungal infections (HP:0002841)2.21508438
85Increased serum ferritin (HP:0003281)2.21179448
863-Methylglutaconic aciduria (HP:0003535)2.18935088
87Postnatal microcephaly (HP:0005484)2.18396202
88Loss of speech (HP:0002371)2.17435175
89Joint stiffness (HP:0001387)2.16863970
90Neuroendocrine neoplasm (HP:0100634)2.16302716
91Abnormal protein glycosylation (HP:0012346)2.16038488
92Abnormal glycosylation (HP:0012345)2.16038488
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16038488
94Abnormal protein N-linked glycosylation (HP:0012347)2.16038488
95Hyperparathyroidism (HP:0000843)2.15970580
96Pheochromocytoma (HP:0002666)2.15465731
97Petechiae (HP:0000967)2.12056798
98Hematochezia (HP:0002573)2.07612814
99Coxa valga (HP:0002673)2.06513627
100Large eyes (HP:0001090)2.06260885
101Abnormality of dental color (HP:0011073)2.03441773
102Failure to thrive in infancy (HP:0001531)2.00125297
103Limb dystonia (HP:0002451)2.00115127
104Myositis (HP:0100614)1.99317421
105Abnormality of the heme biosynthetic pathway (HP:0010472)1.97993353
106Oral leukoplakia (HP:0002745)1.97649158
107Optic disc pallor (HP:0000543)1.97540609
108Respiratory difficulties (HP:0002880)1.96182978
109Premature loss of primary teeth (HP:0006323)1.95501458
110Abolished electroretinogram (ERG) (HP:0000550)1.93169812
111Chronic hepatic failure (HP:0100626)1.91770592
112Reduced antithrombin III activity (HP:0001976)1.91685033
113Leukodystrophy (HP:0002415)1.91126459
114Cerebral edema (HP:0002181)1.90666126
115Gastrointestinal infarctions (HP:0005244)1.90519614
116Cerebral palsy (HP:0100021)1.90391460
117Cutaneous melanoma (HP:0012056)1.88791224
118Abnormality of iron homeostasis (HP:0011031)1.88255572
119Late onset (HP:0003584)1.88218902
120Vertebral compression fractures (HP:0002953)1.87689823
121Ankle clonus (HP:0011448)1.87654108
122Stomatitis (HP:0010280)1.85107433
123Hydroureter (HP:0000072)1.85059365
124Agammaglobulinemia (HP:0004432)1.83709161
125Abnormal rod and cone electroretinograms (HP:0008323)1.83309279
126Oligomenorrhea (HP:0000876)1.82523785
127Abnormality of transition element cation homeostasis (HP:0011030)1.81145727
128Progressive microcephaly (HP:0000253)1.81053370
129Abnormality of the columella (HP:0009929)1.80380305
130Stridor (HP:0010307)1.80232438
131Recurrent bacterial skin infections (HP:0005406)1.80020740
132Focal dystonia (HP:0004373)1.79925970
133Adactyly (HP:0009776)1.78544910
134Hyperphosphaturia (HP:0003109)1.77833783
135Retinal dysplasia (HP:0007973)1.77293377
136Trismus (HP:0000211)1.76589077
137Amblyopia (HP:0000646)1.75564680
138Thrombocytosis (HP:0001894)1.75435075
139Progressive neurologic deterioration (HP:0002344)1.75114154
140Peripheral hypomyelination (HP:0007182)1.73306467
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73305460
142Short femoral neck (HP:0100864)1.72783479
143Thoracolumbar scoliosis (HP:0002944)1.72546549
144Growth hormone excess (HP:0000845)1.72053399
145Limb-girdle muscle atrophy (HP:0003797)1.71676799
146Type II lissencephaly (HP:0007260)1.71602448
147Opisthotonus (HP:0002179)1.71578538
148Broad distal phalanx of finger (HP:0009836)1.71170322
149Recurrent abscess formation (HP:0002722)1.70001750
150Menstrual irregularities (HP:0000858)1.69852836
151Asymmetric septal hypertrophy (HP:0001670)1.67869975
152Recurrent skin infections (HP:0001581)1.67407334
153Progressive external ophthalmoplegia (HP:0000590)1.66557207
154Craniofacial dystonia (HP:0012179)1.66067323
155Abnormality of the aortic arch (HP:0012303)1.65993088
156Progressive muscle weakness (HP:0003323)1.65889715
157Broad face (HP:0000283)1.65756519
158Restlessness (HP:0000711)1.65297040
159Agitation (HP:0000713)1.64175368
160Death in infancy (HP:0001522)1.63760591
161Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.62782757
162Anxiety (HP:0000739)1.61586103
163CNS hypomyelination (HP:0003429)1.61564415
164Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61171608
165Panhypogammaglobulinemia (HP:0003139)1.60604778
166Pulmonary infiltrates (HP:0002113)1.60236072
167External ophthalmoplegia (HP:0000544)1.59990572
168Abnormality of the thoracic spine (HP:0100711)1.58925442
169Muscle fiber atrophy (HP:0100295)1.58900916
170Progressive visual loss (HP:0000529)1.58817104
171Hypertensive crisis (HP:0100735)1.58487519
172Abnormality of pain sensation (HP:0010832)1.57491544
173Impaired pain sensation (HP:0007328)1.57491544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.39946566
2STK164.19745075
3TESK23.55359113
4ARAF3.33082220
5NME22.90222898
6CDK192.85861526
7MAP4K22.72511479
8MAP3K112.68028203
9MAP3K102.63271849
10KDR2.63268948
11BRAF2.38279892
12IRAK32.34672358
13CAMKK22.32879054
14TLK12.17647712
15LIMK12.16558895
16PIM22.09542263
17EIF2AK12.02488212
18TESK11.99382264
19MAP3K121.97302543
20NME11.96841146
21FRK1.85083018
22SCYL21.72807344
23BCKDK1.62114557
24TXK1.55578837
25MINK11.47202126
26IKBKB1.40507540
27FES1.40078807
28DYRK31.39374612
29ERN11.36914740
30WEE11.36392938
31BLK1.33851412
32MAP3K91.33550393
33IRAK41.32364164
34PRKD21.23565749
35AURKA1.23507602
36TAOK11.21889242
37MAP4K11.19040831
38SIK21.16460976
39ZAP701.15024902
40MAP2K21.14604001
41VRK21.13900016
42PAK41.11807320
43DYRK21.09690169
44UHMK11.08397463
45CAMKK11.06335744
46ILK1.04404057
47PINK11.03446209
48KIT1.02716155
49DYRK1B1.00967629
50MAP3K41.00532671
51RPS6KL11.00474716
52RPS6KC11.00474716
53JAK30.99821816
54DAPK30.99702801
55RPS6KA60.99543035
56RAF10.99344402
57RPS6KA20.98621932
58MATK0.97731877
59GRK70.97311417
60SYK0.97216419
61SMG10.95798235
62MUSK0.93273713
63MAP2K60.91777532
64ITK0.91418444
65PAK10.89960425
66CDK140.88076066
67BRSK10.87371048
68MARK30.85688897
69EIF2AK30.85502104
70VRK10.82771091
71CDK11A0.80615555
72PRKCI0.79266169
73ABL20.77429421
74FLT30.77046389
75CSNK1A1L0.76645364
76BTK0.75830351
77DAPK10.75266779
78CSNK1G20.75080491
79MAP3K140.74957649
80PAK60.74701468
81TAOK20.74449393
82BRSK20.73427963
83CDK70.73281088
84CDK80.72681092
85CSF1R0.71557281
86NEK10.70812163
87TNK20.70703450
88CDK180.70387947
89LYN0.69547416
90KSR20.69008297
91RIPK40.68618577
92SRPK10.68372387
93MAPKAPK30.67020629
94CDK150.66973580
95IRAK10.64403336
96TIE10.63916712
97CSNK1G30.63651938
98MYLK0.63383903
99PASK0.63379010
100PKN10.63078658
101HCK0.59835501
102CSK0.59376558
103LRRK20.58509828
104CHUK0.56195216
105LCK0.55725212
106PHKG10.55593740
107PHKG20.55593740
108MAPK110.54970394
109CAMK2G0.54883707
110MARK20.54461126
111STK110.53169556
112NTRK10.52097020
113IKBKE0.51961827
114GRK60.51695074
115LATS20.50544806
116RPS6KA40.50095653
117PDPK10.49098260
118PIM10.48873507
119NTRK30.48672860
120MAP3K80.48222772
121CDC42BPA0.47745072
122TRIB30.47509561
123MAP2K40.47482335
124TAOK30.46734790
125TBK10.46401834
126CAMK10.45847742
127ADRBK10.45478799
128MAP2K30.45189850
129MARK10.45101050
130DDR20.44809835
131MAP3K10.43947284
132PRKD30.43652629
133PDK10.43640124
134MAPK40.42928450
135PRKCG0.42719278
136PRKCQ0.42568447
137MAP2K70.41886664
138CSNK1G10.41791926
139PRPF4B0.41487093
140PRKG20.40396624
141CDK40.39074052
142IRAK20.38911237
143CAMK2B0.36897363
144MAPK130.36715055
145GRK50.34724377
146ADRBK20.34521227
147CSNK2A10.33741710
148SIK30.33066588
149PLK10.32821578
150DAPK20.32819283
151HIPK20.32315678
152CSNK2A20.30026986
153CDK50.28820157
154RPS6KA50.27683860
155MAP2K10.27595915
156ACVR1B0.26980576

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.47627865
2Proteasome_Homo sapiens_hsa030504.55684534
3Oxidative phosphorylation_Homo sapiens_hsa001904.05750309
4Parkinsons disease_Homo sapiens_hsa050123.90042740
5DNA replication_Homo sapiens_hsa030303.73569798
6Allograft rejection_Homo sapiens_hsa053303.01692794
7Mismatch repair_Homo sapiens_hsa034302.82063369
8Graft-versus-host disease_Homo sapiens_hsa053322.67694600
9Huntingtons disease_Homo sapiens_hsa050162.65608589
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.62153782
11RNA polymerase_Homo sapiens_hsa030202.58898735
12Alzheimers disease_Homo sapiens_hsa050102.57261581
13Autoimmune thyroid disease_Homo sapiens_hsa053202.53824935
14Sulfur relay system_Homo sapiens_hsa041222.50108243
15Asthma_Homo sapiens_hsa053102.49572700
16Type I diabetes mellitus_Homo sapiens_hsa049402.41566484
17Pyrimidine metabolism_Homo sapiens_hsa002402.38773793
18Rheumatoid arthritis_Homo sapiens_hsa053232.14543888
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13402796
20Spliceosome_Homo sapiens_hsa030402.06931077
21Base excision repair_Homo sapiens_hsa034101.98272250
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86200109
23Nucleotide excision repair_Homo sapiens_hsa034201.82861310
24Cardiac muscle contraction_Homo sapiens_hsa042601.78834633
25Folate biosynthesis_Homo sapiens_hsa007901.76021793
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71383523
27Homologous recombination_Homo sapiens_hsa034401.70694721
28Protein export_Homo sapiens_hsa030601.67192160
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.61499917
30Osteoclast differentiation_Homo sapiens_hsa043801.59547443
31Synaptic vesicle cycle_Homo sapiens_hsa047211.57915213
32Tuberculosis_Homo sapiens_hsa051521.56808538
33Leishmaniasis_Homo sapiens_hsa051401.54772321
34Antigen processing and presentation_Homo sapiens_hsa046121.50084531
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49602567
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.49201053
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48037252
38Staphylococcus aureus infection_Homo sapiens_hsa051501.45273571
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43076369
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39730691
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39186925
42Purine metabolism_Homo sapiens_hsa002301.35288538
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31357622
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30129298
45Fatty acid elongation_Homo sapiens_hsa000621.29221971
46RNA transport_Homo sapiens_hsa030131.23422656
47Hematopoietic cell lineage_Homo sapiens_hsa046401.19795903
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13936113
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12027110
50Viral myocarditis_Homo sapiens_hsa054161.11251258
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09244355
52Pentose phosphate pathway_Homo sapiens_hsa000301.05806690
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04974051
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00438767
55Phototransduction_Homo sapiens_hsa047441.00064136
56Vibrio cholerae infection_Homo sapiens_hsa051100.97426011
57Salmonella infection_Homo sapiens_hsa051320.96637345
58Phagosome_Homo sapiens_hsa041450.95964495
59B cell receptor signaling pathway_Homo sapiens_hsa046620.95208554
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.94596670
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91209722
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89064600
63Biosynthesis of amino acids_Homo sapiens_hsa012300.89025735
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88883492
65Peroxisome_Homo sapiens_hsa041460.87879138
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87580609
67Malaria_Homo sapiens_hsa051440.87266530
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86834598
69Oocyte meiosis_Homo sapiens_hsa041140.86274551
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.86156418
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84392586
72Acute myeloid leukemia_Homo sapiens_hsa052210.83675480
73Fructose and mannose metabolism_Homo sapiens_hsa000510.83138610
74Pertussis_Homo sapiens_hsa051330.82732307
75Sulfur metabolism_Homo sapiens_hsa009200.81343031
76Cell cycle_Homo sapiens_hsa041100.80852036
77Shigellosis_Homo sapiens_hsa051310.80359640
78N-Glycan biosynthesis_Homo sapiens_hsa005100.77713213
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76762847
80Sphingolipid metabolism_Homo sapiens_hsa006000.76471512
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75196695
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72431205
83Primary immunodeficiency_Homo sapiens_hsa053400.71958877
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70764292
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69325117
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69299576
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69084419
88Alcoholism_Homo sapiens_hsa050340.67936923
89Herpes simplex infection_Homo sapiens_hsa051680.67000676
90Olfactory transduction_Homo sapiens_hsa047400.66204276
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.65615866
92Collecting duct acid secretion_Homo sapiens_hsa049660.64572992
93Carbon metabolism_Homo sapiens_hsa012000.64395950
94Toxoplasmosis_Homo sapiens_hsa051450.63718867
95TNF signaling pathway_Homo sapiens_hsa046680.63605040
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61696628
97Selenocompound metabolism_Homo sapiens_hsa004500.61139830
98Thyroid cancer_Homo sapiens_hsa052160.60751964
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60318581
100Arginine and proline metabolism_Homo sapiens_hsa003300.60136493
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.59090271
102T cell receptor signaling pathway_Homo sapiens_hsa046600.58779884
103Epstein-Barr virus infection_Homo sapiens_hsa051690.58689596
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58165579
105Fanconi anemia pathway_Homo sapiens_hsa034600.58098585
106Metabolic pathways_Homo sapiens_hsa011000.56579166
107Regulation of autophagy_Homo sapiens_hsa041400.56297608
108Ovarian steroidogenesis_Homo sapiens_hsa049130.55812655
109Basal transcription factors_Homo sapiens_hsa030220.55233561
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53829446
111Butanoate metabolism_Homo sapiens_hsa006500.53652973
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53645736
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52897000
114RNA degradation_Homo sapiens_hsa030180.52523824
115Galactose metabolism_Homo sapiens_hsa000520.52483545
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51467568
117Tryptophan metabolism_Homo sapiens_hsa003800.50307447
118Pyruvate metabolism_Homo sapiens_hsa006200.49702811
119African trypanosomiasis_Homo sapiens_hsa051430.47963623
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47852389
121Ether lipid metabolism_Homo sapiens_hsa005650.47541405
122Glutathione metabolism_Homo sapiens_hsa004800.45766201
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45446426
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.43602625
125Gap junction_Homo sapiens_hsa045400.43546257
126Bladder cancer_Homo sapiens_hsa052190.42990690
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40363107
128Insulin secretion_Homo sapiens_hsa049110.40145535
129Other glycan degradation_Homo sapiens_hsa005110.39910185
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39828276
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38845725
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36953933
133Dopaminergic synapse_Homo sapiens_hsa047280.35813371
134Influenza A_Homo sapiens_hsa051640.35691920
135ABC transporters_Homo sapiens_hsa020100.34461518
136Apoptosis_Homo sapiens_hsa042100.34401255
137VEGF signaling pathway_Homo sapiens_hsa043700.33158426
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.30771586
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30555007
140GABAergic synapse_Homo sapiens_hsa047270.30396876
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30039862
142p53 signaling pathway_Homo sapiens_hsa041150.29242317
143Prion diseases_Homo sapiens_hsa050200.25590275
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.24945417
145Circadian entrainment_Homo sapiens_hsa047130.24638588
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24066786
147Long-term potentiation_Homo sapiens_hsa047200.23117146
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22486420
149Cholinergic synapse_Homo sapiens_hsa047250.21923779
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21453952
151Systemic lupus erythematosus_Homo sapiens_hsa053220.18538245
152Arachidonic acid metabolism_Homo sapiens_hsa005900.18285915
153Morphine addiction_Homo sapiens_hsa050320.17535697
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.17428339
155Endocytosis_Homo sapiens_hsa041440.17393147
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17125079
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16273388
158Lysosome_Homo sapiens_hsa041420.15954160
159Amphetamine addiction_Homo sapiens_hsa050310.15941225
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14935045
161Taste transduction_Homo sapiens_hsa047420.12646652
162Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10157615
163One carbon pool by folate_Homo sapiens_hsa006700.09533155

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