TPGS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of peptidyl-lysine acetylation (GO:2000757)4.33627043
2negative regulation of histone acetylation (GO:0035067)4.25834531
3neuron cell-cell adhesion (GO:0007158)4.22015431
4microtubule depolymerization (GO:0007019)4.11968468
5negative regulation of protein acetylation (GO:1901984)4.03428397
6presynaptic membrane assembly (GO:0097105)3.95029692
7microtubule polymerization or depolymerization (GO:0031109)3.93790191
8postsynaptic membrane organization (GO:0001941)3.90043500
9chromatin remodeling at centromere (GO:0031055)3.84963112
10synaptic vesicle exocytosis (GO:0016079)3.79884065
11CENP-A containing nucleosome assembly (GO:0034080)3.77949895
12protein localization to synapse (GO:0035418)3.75354539
13piRNA metabolic process (GO:0034587)3.71462309
14axonemal dynein complex assembly (GO:0070286)3.70030076
15epithelial cilium movement (GO:0003351)3.66848990
16establishment of integrated proviral latency (GO:0075713)3.65258167
17vocalization behavior (GO:0071625)3.58199678
18neuronal action potential propagation (GO:0019227)3.56099002
19presynaptic membrane organization (GO:0097090)3.52394335
20negative regulation of dendrite morphogenesis (GO:0050774)3.49625180
21negative regulation of B cell apoptotic process (GO:0002903)3.47043194
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44526876
23positive regulation of mitochondrial fission (GO:0090141)3.42936021
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40908778
25cilium movement (GO:0003341)3.39970541
26pyrimidine nucleobase catabolic process (GO:0006208)3.38088265
27chaperone-mediated protein transport (GO:0072321)3.36904186
28acrosome reaction (GO:0007340)3.36027189
29DNA double-strand break processing (GO:0000729)3.34603452
30peptidyl-arginine omega-N-methylation (GO:0035247)3.31230249
31male meiosis (GO:0007140)3.30348664
32protein localization to cilium (GO:0061512)3.25319455
33histone exchange (GO:0043486)3.25075732
34DNA strand elongation involved in DNA replication (GO:0006271)3.22264584
35DNA replication-independent nucleosome assembly (GO:0006336)3.22089144
36DNA replication-independent nucleosome organization (GO:0034724)3.22089144
37regulation of podosome assembly (GO:0071801)3.21452369
38positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21443215
39telomere maintenance via semi-conservative replication (GO:0032201)3.17377932
40regulation of cilium movement (GO:0003352)3.16828273
41DNA ligation (GO:0006266)3.14280472
42histone H2A acetylation (GO:0043968)3.13302044
43DNA strand elongation (GO:0022616)3.12496868
44cilium or flagellum-dependent cell motility (GO:0001539)3.12153889
45glutamate secretion (GO:0014047)3.09635753
46SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.07498727
47intraciliary transport (GO:0042073)3.06905712
48peptidyl-arginine methylation (GO:0018216)3.04952315
49peptidyl-arginine N-methylation (GO:0035246)3.04952315
50positive regulation of organelle assembly (GO:1902117)3.03888202
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99268593
52DNA damage response, detection of DNA damage (GO:0042769)2.98859595
53histone arginine methylation (GO:0034969)2.97132715
54regulation of glutamate receptor signaling pathway (GO:1900449)2.97127982
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93999221
56righting reflex (GO:0060013)2.93651823
57neurofilament cytoskeleton organization (GO:0060052)2.92739211
58DNA methylation involved in gamete generation (GO:0043046)2.92502847
59neurotransmitter-gated ion channel clustering (GO:0072578)2.91869259
60serotonin receptor signaling pathway (GO:0007210)2.91519005
61generation of neurons (GO:0048699)2.89849200
62resolution of meiotic recombination intermediates (GO:0000712)2.89767018
63motile cilium assembly (GO:0044458)2.89187142
64negative regulation of dendrite development (GO:2000171)2.87844565
65mitotic sister chromatid segregation (GO:0000070)2.87635810
66metallo-sulfur cluster assembly (GO:0031163)2.86221768
67iron-sulfur cluster assembly (GO:0016226)2.86221768
68establishment of viral latency (GO:0019043)2.85628899
69negative regulation of homotypic cell-cell adhesion (GO:0034111)2.85501610
70regulation of synaptic vesicle exocytosis (GO:2000300)2.84913853
71startle response (GO:0001964)2.84716415
72DNA deamination (GO:0045006)2.84520751
73inositol phosphate catabolic process (GO:0071545)2.84457889
74kinetochore organization (GO:0051383)2.81857781
75ATP-dependent chromatin remodeling (GO:0043044)2.81838477
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.81231836
77ionotropic glutamate receptor signaling pathway (GO:0035235)2.79310444
78spindle checkpoint (GO:0031577)2.78924299
79multicellular organism reproduction (GO:0032504)2.78425220
80synaptic transmission, glutamatergic (GO:0035249)2.77943701
81protein deneddylation (GO:0000338)2.76930299
82sister chromatid segregation (GO:0000819)2.76846452
83cullin deneddylation (GO:0010388)2.76073611
84negative regulation of chromosome segregation (GO:0051985)2.75237682
85DNA unwinding involved in DNA replication (GO:0006268)2.74825903
86regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74558356
87negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74521238
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.74521238
89negative regulation of sister chromatid segregation (GO:0033046)2.74521238
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74521238
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74521238
92glutamate receptor signaling pathway (GO:0007215)2.73903097
93centriole replication (GO:0007099)2.73252895
94cell migration in hindbrain (GO:0021535)2.72033485
95mitotic spindle checkpoint (GO:0071174)2.71836460
96non-recombinational repair (GO:0000726)2.70655449
97double-strand break repair via nonhomologous end joining (GO:0006303)2.70655449
98kinetochore assembly (GO:0051382)2.70300267
99DNA replication checkpoint (GO:0000076)2.70064688
100protein localization to kinetochore (GO:0034501)2.69833018
101proteasome assembly (GO:0043248)2.69520238
102neuron-neuron synaptic transmission (GO:0007270)2.69415956
103calcium ion-dependent exocytosis (GO:0017156)2.69293415
104mitotic spindle assembly checkpoint (GO:0007094)2.69132936
105acrosome assembly (GO:0001675)2.68847799
106mitotic recombination (GO:0006312)2.68286815
107protein polyglutamylation (GO:0018095)2.67542848
108spindle assembly checkpoint (GO:0071173)2.67270086
109dendrite development (GO:0016358)2.67144922
110sperm motility (GO:0030317)2.66854885
111telomere maintenance via recombination (GO:0000722)2.64921492
112mitotic metaphase plate congression (GO:0007080)2.64836507
113DNA replication-dependent nucleosome assembly (GO:0006335)2.63893175
114DNA replication-dependent nucleosome organization (GO:0034723)2.63893175
115synapsis (GO:0007129)2.62950341
116negative regulation of DNA recombination (GO:0045910)2.62558068
117regulation of synaptic vesicle transport (GO:1902803)2.62281868
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61363079
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60406222
120L-serine metabolic process (GO:0006563)2.59292266
121protein localization to chromosome, centromeric region (GO:0071459)2.57105314
122de novo posttranslational protein folding (GO:0051084)2.56423726
123positive regulation of neurotransmitter transport (GO:0051590)2.56212945
124regulation of meiosis I (GO:0060631)2.55589938
125attachment of spindle microtubules to kinetochore (GO:0008608)2.55318948
126DNA replication initiation (GO:0006270)2.55004265
127mitotic spindle organization (GO:0007052)2.54903978
128positive regulation of synapse assembly (GO:0051965)2.54887408
129de novo protein folding (GO:0006458)2.54017980
130protein neddylation (GO:0045116)2.53193640
131regulation of chromosome segregation (GO:0051983)2.51984668
132base-excision repair (GO:0006284)2.50569671
133positive regulation of neurotransmitter secretion (GO:0001956)2.50210026
134purine nucleobase biosynthetic process (GO:0009113)2.50003299
135protein localization to chromosome (GO:0034502)2.49864608
136cranial nerve structural organization (GO:0021604)2.47520123
137facial nerve structural organization (GO:0021612)2.47126692
138sequestering of actin monomers (GO:0042989)2.47022119
139regulation of mitotic sister chromatid separation (GO:0010965)2.47014962
140regulation of mitotic sister chromatid segregation (GO:0033047)2.47014962
141regulation of sister chromatid segregation (GO:0033045)2.47014962
142neurotransmitter secretion (GO:0007269)2.46973903
143DNA catabolic process, exonucleolytic (GO:0000738)2.46877330
144regulation of cell maturation (GO:1903429)2.45977531
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45432205
146somatic hypermutation of immunoglobulin genes (GO:0016446)2.45125109
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45125109
148metaphase plate congression (GO:0051310)2.45118083
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45073498
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.45056078
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.44829527
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.44829527
153mitochondrial fission (GO:0000266)2.43748312
154positive regulation of synaptic transmission, GABAergic (GO:0032230)2.41585395
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41178293
156establishment of mitochondrion localization (GO:0051654)2.40765485
157microtubule severing (GO:0051013)2.40442968
158positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.40412385
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40246780
160striatum development (GO:0021756)2.39915459
161mitotic chromosome condensation (GO:0007076)2.39866560
162positive regulation of membrane potential (GO:0045838)2.39600798
163regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.39496673
164axoneme assembly (GO:0035082)2.39491138
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.39299742
166nucleobase catabolic process (GO:0046113)2.38422508
167atrial cardiac muscle cell action potential (GO:0086014)2.38272287
168photoreceptor cell differentiation (GO:0046530)2.37308551
169eye photoreceptor cell differentiation (GO:0001754)2.37308551
170peripheral nervous system neuron development (GO:0048935)2.36169786
171synaptic vesicle docking involved in exocytosis (GO:0016081)2.35885093
172nonmotile primary cilium assembly (GO:0035058)2.35600510
173cilium assembly (GO:0042384)2.35479528
174mismatch repair (GO:0006298)2.34409395
175behavioral response to ethanol (GO:0048149)2.34241228
176synapse assembly (GO:0007416)2.32966025
177cilium organization (GO:0044782)2.32136373
178synaptic vesicle maturation (GO:0016188)2.31884936
179regulation of mitochondrial fission (GO:0090140)2.31457203
180mitotic cell cycle (GO:0000278)2.31131678
181positive regulation of potassium ion transmembrane transport (GO:1901381)2.30673653
182regulation of neuronal synaptic plasticity (GO:0048168)2.30624031
183telomere maintenance via telomere lengthening (GO:0010833)2.30111410
184replication fork processing (GO:0031297)2.29992771
185meiotic chromosome segregation (GO:0045132)2.29092374
186protein K11-linked ubiquitination (GO:0070979)2.28342448
187spermatid nucleus differentiation (GO:0007289)2.27358531
188postreplication repair (GO:0006301)2.25834663
189tRNA aminoacylation for protein translation (GO:0006418)2.25731396
190regulation of nuclear cell cycle DNA replication (GO:0033262)2.24921702
191regulation of double-strand break repair via homologous recombination (GO:0010569)2.24246355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51967657
2EZH2_22144423_ChIP-Seq_EOC_Human5.44645608
3GBX2_23144817_ChIP-Seq_PC3_Human3.69157647
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64722212
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46175891
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33363304
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.94715582
8TAF15_26573619_Chip-Seq_HEK293_Human2.93939599
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85761706
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.78249427
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.77256306
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70667417
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60778886
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.59992113
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.57259416
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53849375
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48800603
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46874516
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31500215
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30456775
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26775966
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26012098
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24495800
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23675280
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.23401426
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20521122
27IGF1R_20145208_ChIP-Seq_DFB_Human2.20122293
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18173126
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12846233
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12634616
31RNF2_27304074_Chip-Seq_NSC_Mouse2.12294174
32CBX2_27304074_Chip-Seq_ESCs_Mouse2.05770819
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04935580
34VDR_22108803_ChIP-Seq_LS180_Human2.03420274
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98396871
36ELK1_19687146_ChIP-ChIP_HELA_Human1.96982403
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95101555
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.94204254
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.94145448
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92962347
41REST_21632747_ChIP-Seq_MESCs_Mouse1.92324197
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89789346
43FUS_26573619_Chip-Seq_HEK293_Human1.88247998
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87857660
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87195192
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86080833
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.85700773
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84269005
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83836914
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82191350
51P300_19829295_ChIP-Seq_ESCs_Human1.81664782
52GABP_19822575_ChIP-Seq_HepG2_Human1.81389903
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80909625
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78805198
55XRN2_22483619_ChIP-Seq_HELA_Human1.75656502
56DCP1A_22483619_ChIP-Seq_HELA_Human1.74933813
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74895297
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74157475
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73815408
60TTF2_22483619_ChIP-Seq_HELA_Human1.73095435
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71544641
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70938298
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70802320
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70802320
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70471260
66VDR_23849224_ChIP-Seq_CD4+_Human1.66305778
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65980580
68MYC_18940864_ChIP-ChIP_HL60_Human1.65067486
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64811725
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62987040
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.62461416
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61550205
73SMAD4_21799915_ChIP-Seq_A2780_Human1.61492068
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61001271
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58925373
76FOXP3_21729870_ChIP-Seq_TREG_Human1.58584861
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.56406132
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.54973960
79EWS_26573619_Chip-Seq_HEK293_Human1.54916854
80IRF1_19129219_ChIP-ChIP_H3396_Human1.54218106
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53393925
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51254498
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.50875209
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50572396
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50283077
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49807943
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49724847
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49350356
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49146830
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.49042036
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48768954
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48153331
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47515055
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47302493
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46121174
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43682857
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.43673269
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43422007
99AR_21909140_ChIP-Seq_LNCAP_Human1.43413624
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39274002
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.38016394
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.36906318
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.35432371
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.34843641
105AR_21572438_ChIP-Seq_LNCaP_Human1.34520705
106AR_25329375_ChIP-Seq_VCAP_Human1.34435761
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.33258602
108KDM2B_26808549_Chip-Seq_REH_Human1.33120118
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33079963
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32805876
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31762392
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30857420
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30512264
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30512264
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29661807
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29157127
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.28343363
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28177836
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27990443
120JUN_21703547_ChIP-Seq_K562_Human1.26368397
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25602403
122P53_22387025_ChIP-Seq_ESCs_Mouse1.25565689
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25127527
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.24553454
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.23233545
126ER_23166858_ChIP-Seq_MCF-7_Human1.23003716
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.22882269
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22675866
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22262348
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20712436
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18876051
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17955152
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17630857
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17325846
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.17145038
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16057003
137SMAD_19615063_ChIP-ChIP_OVARY_Human1.15867245
138STAT3_18555785_Chip-Seq_ESCs_Mouse1.15861307
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15587534
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15485884
141STAT3_23295773_ChIP-Seq_U87_Human1.14212048
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12376251
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12194462
144TCF4_23295773_ChIP-Seq_U87_Human1.12120302
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12052285
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10868141
147SOX2_18555785_Chip-Seq_ESCs_Mouse1.09651561
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.09484409
149P300_18555785_Chip-Seq_ESCs_Mouse1.09466683
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08622581
151ZNF274_21170338_ChIP-Seq_K562_Hela1.08066586
152HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07578936
153TP63_19390658_ChIP-ChIP_HaCaT_Human1.07534814
154NMYC_18555785_Chip-Seq_ESCs_Mouse1.06423519
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05657636
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05184618
157EZH2_27294783_Chip-Seq_NPCs_Mouse1.05175059
158WT1_19549856_ChIP-ChIP_CCG9911_Human1.05047217
159RUNX2_22187159_ChIP-Seq_PCA_Human1.03082018
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02681768
161SOX9_26525672_Chip-Seq_HEART_Mouse1.02162835
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01744650
163RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01124573
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96984431
165KDM5A_27292631_Chip-Seq_BREAST_Human0.95810535
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93088182
167TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90913595
168CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90792108
169ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90622148
170CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86647833
171NANOG_21062744_ChIP-ChIP_HESCs_Human0.84392937
172NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84382040
173SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82946821
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80101354
175SOX17_20123909_ChIP-Seq_XEN_Mouse0.80098973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia5.76612082
2MP0003880_abnormal_central_pattern4.23919804
3MP0004859_abnormal_synaptic_plasticity2.91656207
4MP0002735_abnormal_chemical_nociception2.83687407
5MP0008058_abnormal_DNA_repair2.79055956
6MP0010094_abnormal_chromosome_stability2.73226748
7MP0006276_abnormal_autonomic_nervous2.71860035
8MP0003693_abnormal_embryo_hatching2.69780718
9MP0001968_abnormal_touch/_nociception2.69287567
10MP0002734_abnormal_mechanical_nocicepti2.65374121
11MP0001986_abnormal_taste_sensitivity2.60849679
12MP0001188_hyperpigmentation2.54676136
13MP0008057_abnormal_DNA_replication2.43752634
14MP0002736_abnormal_nociception_after2.41424291
15MP0003635_abnormal_synaptic_transmissio2.38012716
16MP0008932_abnormal_embryonic_tissue2.30728225
17MP0003111_abnormal_nucleus_morphology2.30339907
18MP0003646_muscle_fatigue2.27747896
19MP0005423_abnormal_somatic_nervous2.22499267
20MP0006292_abnormal_olfactory_placode2.16801423
21MP0005410_abnormal_fertilization2.14167879
22MP0004957_abnormal_blastocyst_morpholog2.08565324
23MP0003077_abnormal_cell_cycle2.05502711
24MP0002102_abnormal_ear_morphology2.02876972
25MP0009745_abnormal_behavioral_response2.02088229
26MP0001984_abnormal_olfaction2.01620569
27MP0009379_abnormal_foot_pigmentation2.00721843
28MP0005646_abnormal_pituitary_gland2.00647658
29MP0002063_abnormal_learning/memory/cond1.98877002
30MP0002272_abnormal_nervous_system1.93286414
31MP0002572_abnormal_emotion/affect_behav1.89042916
32MP0008877_abnormal_DNA_methylation1.88479994
33MP0009046_muscle_twitch1.87921181
34MP0001905_abnormal_dopamine_level1.85493329
35MP0001486_abnormal_startle_reflex1.82220753
36MP0001529_abnormal_vocalization1.81912446
37MP0002067_abnormal_sensory_capabilities1.79299980
38MP0003787_abnormal_imprinting1.79170442
39MP0002064_seizures1.77060678
40MP0002184_abnormal_innervation1.71186196
41MP0004147_increased_porphyrin_level1.68754875
42MP0000778_abnormal_nervous_system1.64024799
43MP0001970_abnormal_pain_threshold1.63369451
44MP0005171_absent_coat_pigmentation1.62559125
45MP0001293_anophthalmia1.61437842
46MP0003937_abnormal_limbs/digits/tail_de1.50825367
47MP0002733_abnormal_thermal_nociception1.49546204
48MP0003890_abnormal_embryonic-extraembry1.48696268
49MP0001501_abnormal_sleep_pattern1.43406144
50MP0002557_abnormal_social/conspecific_i1.42878923
51MP0000372_irregular_coat_pigmentation1.40393608
52MP0002234_abnormal_pharynx_morphology1.39479386
53MP0003698_abnormal_male_reproductive1.37362724
54MP0003136_yellow_coat_color1.36517611
55MP0004133_heterotaxia1.35446634
56MP0005394_taste/olfaction_phenotype1.33614688
57MP0005499_abnormal_olfactory_system1.33614688
58MP0003119_abnormal_digestive_system1.32038271
59MP0002233_abnormal_nose_morphology1.31718245
60MP0002638_abnormal_pupillary_reflex1.31085143
61MP0000015_abnormal_ear_pigmentation1.29547230
62MP0001299_abnormal_eye_distance/1.29229370
63MP0004142_abnormal_muscle_tone1.23717661
64MP0002751_abnormal_autonomic_nervous1.23385392
65MP0001929_abnormal_gametogenesis1.22934415
66MP0002653_abnormal_ependyma_morphology1.22020251
67MP0004924_abnormal_behavior1.21497149
68MP0005386_behavior/neurological_phenoty1.21497149
69MP0003385_abnormal_body_wall1.21078291
70MP0000955_abnormal_spinal_cord1.20416436
71MP0001286_abnormal_eye_development1.18430176
72MP0002882_abnormal_neuron_morphology1.16796450
73MP0003122_maternal_imprinting1.16067665
74MP0008789_abnormal_olfactory_epithelium1.13212491
75MP0005623_abnormal_meninges_morphology1.13210397
76MP0000631_abnormal_neuroendocrine_gland1.13130266
77MP0002249_abnormal_larynx_morphology1.13066894
78MP0003121_genomic_imprinting1.12762537
79MP0002752_abnormal_somatic_nervous1.12462260
80MP0005551_abnormal_eye_electrophysiolog1.12357463
81MP0004811_abnormal_neuron_physiology1.11292140
82MP0002085_abnormal_embryonic_tissue1.11136897
83MP0001963_abnormal_hearing_physiology1.10839936
84MP0002084_abnormal_developmental_patter1.09676288
85MP0003755_abnormal_palate_morphology1.08807179
86MP0008007_abnormal_cellular_replicative1.08094409
87MP0001730_embryonic_growth_arrest1.07722829
88MP0006035_abnormal_mitochondrial_morpho1.06908237
89MP0002822_catalepsy1.06768631
90MP0003879_abnormal_hair_cell1.05979141
91MP0010386_abnormal_urinary_bladder1.05563504
92MP0003567_abnormal_fetal_cardiomyocyte1.05401555
93MP0008995_early_reproductive_senescence1.02424797
94MP0002210_abnormal_sex_determination1.01643485
95MP0001440_abnormal_grooming_behavior1.00375663
96MP0006072_abnormal_retinal_apoptosis1.00098436
97MP0003786_premature_aging0.99670666
98MP0004197_abnormal_fetal_growth/weight/0.99030821
99MP0003942_abnormal_urinary_system0.98339063
100MP0005174_abnormal_tail_pigmentation0.98291658
101MP0002938_white_spotting0.97359025
102MP0000358_abnormal_cell_content/0.95700566
103MP0005409_darkened_coat_color0.95309993
104MP0001502_abnormal_circadian_rhythm0.95301606
105MP0000026_abnormal_inner_ear0.95228568
106MP0004858_abnormal_nervous_system0.93676117
107MP0002697_abnormal_eye_size0.93591236
108MP0002282_abnormal_trachea_morphology0.92899777
109MP0001697_abnormal_embryo_size0.92545603
110MP0004742_abnormal_vestibular_system0.92513841
111MP0002095_abnormal_skin_pigmentation0.92433096
112MP0003718_maternal_effect0.92357421
113MP0005187_abnormal_penis_morphology0.91458923
114MP0009697_abnormal_copulation0.89906144
115MP0000350_abnormal_cell_proliferation0.88884971
116MP0002066_abnormal_motor_capabilities/c0.88539578
117MP0003186_abnormal_redox_activity0.88258897
118MP0008569_lethality_at_weaning0.87882884
119MP0002152_abnormal_brain_morphology0.87698475
120MP0001177_atelectasis0.87495238
121MP0003935_abnormal_craniofacial_develop0.86684738
122MP0003938_abnormal_ear_development0.86497074
123MP0005380_embryogenesis_phenotype0.85834154
124MP0001672_abnormal_embryogenesis/_devel0.85834154
125MP0000534_abnormal_ureter_morphology0.84274091
126MP0010368_abnormal_lymphatic_system0.84125484
127MP0000653_abnormal_sex_gland0.83502166
128MP0001346_abnormal_lacrimal_gland0.83398899
129MP0002161_abnormal_fertility/fecundity0.82875851
130MP0002080_prenatal_lethality0.81967134
131MP0005391_vision/eye_phenotype0.81763713
132MP0002160_abnormal_reproductive_system0.81207996
133MP0004145_abnormal_muscle_electrophysio0.80812281
134MP0000049_abnormal_middle_ear0.80459252
135MP0002177_abnormal_outer_ear0.80140761
136MP0002876_abnormal_thyroid_physiology0.79895340
137MP0002229_neurodegeneration0.79762023
138MP0005645_abnormal_hypothalamus_physiol0.79370745
139MP0002111_abnormal_tail_morphology0.79072720
140MP0010030_abnormal_orbit_morphology0.78734685
141MP0003221_abnormal_cardiomyocyte_apopto0.76851877
142MP0002081_perinatal_lethality0.76636068
143MP0000566_synostosis0.76281668
144MP0003861_abnormal_nervous_system0.74735098
145MP0001145_abnormal_male_reproductive0.74661551
146MP0009250_abnormal_appendicular_skeleto0.72483651
147MP0001919_abnormal_reproductive_system0.71916412
148MP0005253_abnormal_eye_physiology0.71161525
149MP0003315_abnormal_perineum_morphology0.71096420
150MP0000751_myopathy0.68954482
151MP0000569_abnormal_digit_pigmentation0.68835208

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)6.60159775
2Hepatoblastoma (HP:0002884)6.44542417
3Diastasis recti (HP:0001540)6.03756378
4Neonatal hypoglycemia (HP:0001998)5.54047897
5Long foot (HP:0001833)5.45158075
6Abnormal pancreas size (HP:0012094)4.88689225
7High anterior hairline (HP:0009890)4.39430319
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.22219827
9Focal motor seizures (HP:0011153)3.99505904
10Cortical dysplasia (HP:0002539)3.96068585
11Poor coordination (HP:0002370)3.88371576
12Partial agenesis of the corpus callosum (HP:0001338)3.87507702
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.82093122
14Absent/shortened dynein arms (HP:0200106)3.82093122
15Abnormality of the anterior horn cell (HP:0006802)3.63065911
16Degeneration of anterior horn cells (HP:0002398)3.63065911
17Nephroblastoma (Wilms tumor) (HP:0002667)3.58024936
18Abnormal respiratory motile cilium physiology (HP:0012261)3.55534238
19Abnormality of the lower motor neuron (HP:0002366)3.52253912
20Overgrowth (HP:0001548)3.48793221
21Myokymia (HP:0002411)3.39545684
22Embryonal renal neoplasm (HP:0011794)3.37230444
23Amyotrophic lateral sclerosis (HP:0007354)3.32281960
24Neoplasm of the adrenal gland (HP:0100631)3.25188680
25Abnormal ciliary motility (HP:0012262)3.24259642
26Abnormality of the septum pellucidum (HP:0007375)3.21136582
27Fetal akinesia sequence (HP:0001989)3.14238856
28Febrile seizures (HP:0002373)3.12169348
29Abnormal respiratory motile cilium morphology (HP:0005938)3.05896597
30Abnormal respiratory epithelium morphology (HP:0012253)3.05896597
31Medial flaring of the eyebrow (HP:0010747)2.92317431
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.88909702
33Gait imbalance (HP:0002141)2.85521660
34Abnormal glucose tolerance (HP:0001952)2.82317700
35Germ cell neoplasia (HP:0100728)2.76370700
36Broad-based gait (HP:0002136)2.74340685
37Colon cancer (HP:0003003)2.73622667
38True hermaphroditism (HP:0010459)2.66454455
39Epileptic encephalopathy (HP:0200134)2.65872929
40Nephrogenic diabetes insipidus (HP:0009806)2.64055163
41Atonic seizures (HP:0010819)2.63095809
42Congenital primary aphakia (HP:0007707)2.62817722
43Retinal dysplasia (HP:0007973)2.62496540
44Nonprogressive disorder (HP:0003680)2.60796510
45Hyperglycinemia (HP:0002154)2.58388703
46Enlarged kidneys (HP:0000105)2.56168918
47Broad foot (HP:0001769)2.54142231
48Acute myeloid leukemia (HP:0004808)2.48176620
49Abnormal lung lobation (HP:0002101)2.47610402
50Shoulder girdle muscle weakness (HP:0003547)2.47506350
51Pancreatic fibrosis (HP:0100732)2.42589585
52Chromsome breakage (HP:0040012)2.40406103
53Infertility (HP:0000789)2.39629011
54Rhinitis (HP:0012384)2.37637326
55Abnormal hair whorl (HP:0010721)2.35680718
56Hypothermia (HP:0002045)2.32601724
57Hypoplastic pelvis (HP:0008839)2.29874806
58Deep philtrum (HP:0002002)2.28542197
59Embryonal neoplasm (HP:0002898)2.27444747
60Genital tract atresia (HP:0001827)2.24561113
61Limb dystonia (HP:0002451)2.20954812
62Meckel diverticulum (HP:0002245)2.19557715
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.18088860
64Abnormality of glycolysis (HP:0004366)2.16563039
65Progressive cerebellar ataxia (HP:0002073)2.15510224
66Focal seizures (HP:0007359)2.14049028
67Ankle clonus (HP:0011448)2.13229149
68Abnormality of the ileum (HP:0001549)2.12893176
69Vaginal atresia (HP:0000148)2.12719248
70Acute encephalopathy (HP:0006846)2.08473778
71Volvulus (HP:0002580)2.01933890
72Duodenal stenosis (HP:0100867)2.00981801
73Small intestinal stenosis (HP:0012848)2.00981801
74Sclerocornea (HP:0000647)2.00735064
75Genu varum (HP:0002970)1.99918736
76Postnatal microcephaly (HP:0005484)1.99213867
77Abnormality of the labia minora (HP:0012880)1.99043370
78Patellar aplasia (HP:0006443)1.98989141
79Sleep apnea (HP:0010535)1.98784476
80Nephronophthisis (HP:0000090)1.96771518
81Increased serum pyruvate (HP:0003542)1.96651063
82Aplasia/Hypoplasia of the lens (HP:0008063)1.94462960
83Cholecystitis (HP:0001082)1.94202072
84Abnormal gallbladder physiology (HP:0012438)1.94202072
85Increased nuchal translucency (HP:0010880)1.93772386
86Occipital encephalocele (HP:0002085)1.93751265
87Oligodactyly (hands) (HP:0001180)1.91415592
88Medulloblastoma (HP:0002885)1.90523347
89Drooling (HP:0002307)1.88609782
90Aplasia/Hypoplasia of the patella (HP:0006498)1.88424796
91Poor suck (HP:0002033)1.88347379
92Postaxial foot polydactyly (HP:0001830)1.87629869
93Facial cleft (HP:0002006)1.85033085
94Gaze-evoked nystagmus (HP:0000640)1.83902692
95Abnormality of the duodenum (HP:0002246)1.83429742
96Molar tooth sign on MRI (HP:0002419)1.82235553
97Abnormality of midbrain morphology (HP:0002418)1.82235553
98Decreased testicular size (HP:0008734)1.82075998
99Chronic bronchitis (HP:0004469)1.81944933
100Oligodactyly (HP:0012165)1.81079743
101Abnormality of the hip-girdle musculature (HP:0001445)1.80632807
102Abnormality of the musculature of the pelvis (HP:0001469)1.80632807
103Ulnar claw (HP:0001178)1.80456422
104Acute necrotizing encephalopathy (HP:0006965)1.78602289
105Intestinal atresia (HP:0011100)1.78467052
106Obstructive sleep apnea (HP:0002870)1.77498655
107Hyperventilation (HP:0002883)1.76316224
108Split foot (HP:0001839)1.75844047
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.74146486
110Sloping forehead (HP:0000340)1.73862898
111Esotropia (HP:0000565)1.73478492
112Anencephaly (HP:0002323)1.73024659
113Abnormality of chromosome stability (HP:0003220)1.71703644
114Urinary urgency (HP:0000012)1.71435719
115Polyphagia (HP:0002591)1.69765412
116Pancreatic cysts (HP:0001737)1.69646637
117Large hands (HP:0001176)1.68652926
118Progressive inability to walk (HP:0002505)1.67943981
119Visual hallucinations (HP:0002367)1.67038202
120Dandy-Walker malformation (HP:0001305)1.66429140
121Oculomotor apraxia (HP:0000657)1.66114484
122Optic nerve coloboma (HP:0000588)1.65104892
123Macroglossia (HP:0000158)1.64506345
124Upper motor neuron abnormality (HP:0002127)1.64447872
125Tubulointerstitial nephritis (HP:0001970)1.63918284
126Absent forearm bone (HP:0003953)1.63559809
127Aplasia involving forearm bones (HP:0009822)1.63559809
128Micropenis (HP:0000054)1.63313491
129Severe visual impairment (HP:0001141)1.62971937
130Astigmatism (HP:0000483)1.62893171
131Triphalangeal thumb (HP:0001199)1.61385252
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61354072
133Specific learning disability (HP:0001328)1.61313311
134Bifid tongue (HP:0010297)1.61146633
135Abnormality of the corticospinal tract (HP:0002492)1.60443816
136Abnormality of the metopic suture (HP:0005556)1.60363300
137Absent radius (HP:0003974)1.60325550
138Birth length less than 3rd percentile (HP:0003561)1.59764593
139Failure to thrive in infancy (HP:0001531)1.59563262
140Male pseudohermaphroditism (HP:0000037)1.59529804
141Ependymoma (HP:0002888)1.59293125
142Pelvic girdle muscle weakness (HP:0003749)1.57699402
143Abnormal mitochondria in muscle tissue (HP:0008316)1.57525933
144Optic disc pallor (HP:0000543)1.57110308
145Supernumerary spleens (HP:0009799)1.56795280
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.56318011
147Hypoplasia of the brainstem (HP:0002365)1.56318011
148Progressive macrocephaly (HP:0004481)1.55689199
149Excessive salivation (HP:0003781)1.55623051
150Abnormality of glycine metabolism (HP:0010895)1.55337427
151Abnormality of serine family amino acid metabolism (HP:0010894)1.55337427
152Increased CSF lactate (HP:0002490)1.54954856
153Absent speech (HP:0001344)1.54945793
154Median cleft lip (HP:0000161)1.54824348
155Horseshoe kidney (HP:0000085)1.53648717
156Papillary thyroid carcinoma (HP:0002895)1.53095470
157Aganglionic megacolon (HP:0002251)1.52721758
158Postaxial hand polydactyly (HP:0001162)1.52663300
159Narrow forehead (HP:0000341)1.52523353
160Advanced eruption of teeth (HP:0006288)1.51943419
161Lissencephaly (HP:0001339)1.49769581
162Asymmetric growth (HP:0100555)1.49037448
163Decreased central vision (HP:0007663)1.48485503
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.48051242
165Abnormal sex determination (HP:0012244)1.47909566
166Sex reversal (HP:0012245)1.47909566
167Narrow nasal bridge (HP:0000446)1.47768350
168Preaxial hand polydactyly (HP:0001177)1.47162517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.98624470
2STK164.92030039
3MAP3K123.99449243
4MKNK23.76673120
5TRIM283.34981728
6MUSK3.10657669
7PRKG23.10412966
8BUB12.90827395
9MAP2K72.87536235
10MAPK132.42639947
11NEK12.30082501
12WNK32.26225508
13MKNK12.23459567
14TTK2.21330010
15VRK22.14795311
16MARK12.11742705
17MAP3K41.97388493
18MAP4K21.95072857
19TNIK1.94740775
20MINK11.94182915
21NTRK31.88632079
22SIK31.85846171
23ZAK1.83156478
24DYRK31.75252157
25CSNK1A1L1.71449407
26EPHA41.60159323
27CDK81.59811964
28PLK11.55647361
29EIF2AK11.49213912
30BCKDK1.48433426
31CAMK2B1.44777383
32MAP3K91.40082986
33BRAF1.34747657
34PLK21.32635757
35DYRK21.29884908
36SGK21.28796112
37PBK1.25009857
38NTRK21.24843774
39DAPK11.17304357
40PRKD31.17005760
41ATR1.14228111
42RPS6KA41.14123525
43CDK191.11692103
44BMPR1B1.11116819
45CAMK2A1.07031434
46TESK21.05337347
47CAMK2G1.05088815
48PRPF4B1.04816903
49SGK4941.02313405
50SGK2231.02313405
51PNCK1.01087277
52EPHB21.00066582
53CAMK2D0.99899854
54BRSK20.99176505
55MAP2K40.98901919
56PINK10.96541086
57TSSK60.95556408
58AKT30.95360182
59MAP3K60.94779008
60ADRBK20.94610718
61ARAF0.94531812
62CCNB10.94192394
63MYLK0.93319637
64AURKB0.90631050
65PLK40.89699739
66BMPR20.86166598
67BRSK10.85722238
68MAPKAPK50.82511562
69GRK70.80946407
70NUAK10.78547297
71ERBB40.78509398
72GRK50.77130952
73YES10.76976773
74NEK20.76411950
75PHKG20.74038413
76PHKG10.74038413
77SRPK10.73285031
78PRKCG0.71550602
79CDK30.70924291
80ATM0.70645475
81LATS20.70108981
82VRK10.68660203
83PAK30.67900242
84TAF10.65900187
85CHEK10.64928815
86SIK20.64792581
87FLT30.63834079
88CDC70.63716875
89KSR10.63319205
90CDK70.62820954
91LIMK10.61555074
92OXSR10.59337829
93DYRK1A0.57930002
94LMTK20.56890251
95WEE10.54906852
96MAPKAPK30.52892610
97CSNK1G20.52786712
98CDK60.52583836
99PLK30.52467417
100CDK50.51787616
101CDK10.49327426
102TESK10.48464932
103CSNK1G30.46260976
104CDK180.46143411
105ADRBK10.46098139
106STK38L0.45486661
107RAF10.45070734
108CAMKK20.44814886
109BCR0.44257887
110ACVR1B0.43992476
111CDK20.43972913
112PRKG10.43578241
113CSNK1G10.43546985
114PAK60.43521511
115PDK40.41678436
116PDK30.41678436
117PAK10.41542441
118DYRK1B0.41459494
119CSNK2A10.40715656
120MARK20.40294755
121AURKA0.39231958
122SGK30.39219773
123NME10.38409572
124UHMK10.38400309
125PTK2B0.36802335
126CDK40.36371797
127CDK140.35841581
128NEK60.35459116
129CDK150.35436689
130PRKCE0.34401142
131CHEK20.33932939
132PIM20.33556244
133PRKCI0.33163059
134DAPK20.33148829
135STK390.32970943
136TIE10.32523216
137RIPK10.32188351
138PRKDC0.32093246
139CSNK1E0.32010461
140PRKACA0.31893429
141PKN10.30832039
142CSNK1A10.30446426
143MAP2K10.28942300
144CDK11A0.27823131
145ERBB30.27443864
146CAMK10.27418440

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12067985
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88132570
3Non-homologous end-joining_Homo sapiens_hsa034502.41214251
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40689231
5Phototransduction_Homo sapiens_hsa047442.27478441
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27308877
7Olfactory transduction_Homo sapiens_hsa047402.24052510
8Circadian entrainment_Homo sapiens_hsa047132.23170708
9Serotonergic synapse_Homo sapiens_hsa047262.22095221
10Glutamatergic synapse_Homo sapiens_hsa047242.21907136
11Long-term potentiation_Homo sapiens_hsa047202.14321055
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12479481
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09340647
14Long-term depression_Homo sapiens_hsa047302.07171800
15Dopaminergic synapse_Homo sapiens_hsa047282.02526786
16RNA transport_Homo sapiens_hsa030131.89118894
17Collecting duct acid secretion_Homo sapiens_hsa049661.86416946
18Steroid biosynthesis_Homo sapiens_hsa001001.84434375
19Spliceosome_Homo sapiens_hsa030401.81000277
20Insulin secretion_Homo sapiens_hsa049111.79019493
21Salivary secretion_Homo sapiens_hsa049701.78272140
22Oxidative phosphorylation_Homo sapiens_hsa001901.73390018
23Cholinergic synapse_Homo sapiens_hsa047251.71664338
24Amphetamine addiction_Homo sapiens_hsa050311.71203999
25Huntingtons disease_Homo sapiens_hsa050161.67608351
26Propanoate metabolism_Homo sapiens_hsa006401.66667111
27African trypanosomiasis_Homo sapiens_hsa051431.65966828
28Morphine addiction_Homo sapiens_hsa050321.65551650
29Renin secretion_Homo sapiens_hsa049241.65317486
30Gastric acid secretion_Homo sapiens_hsa049711.64538012
31Taste transduction_Homo sapiens_hsa047421.57094674
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56387778
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55023317
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54414536
35GABAergic synapse_Homo sapiens_hsa047271.53309556
36Basal transcription factors_Homo sapiens_hsa030221.51906133
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51471268
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48616528
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.46973180
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46798585
41Biosynthesis of amino acids_Homo sapiens_hsa012301.46762348
42GnRH signaling pathway_Homo sapiens_hsa049121.41820037
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40848314
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.40456547
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37190978
46Alzheimers disease_Homo sapiens_hsa050101.32702073
47Fatty acid elongation_Homo sapiens_hsa000621.31061548
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29955762
49Gap junction_Homo sapiens_hsa045401.29902116
50mRNA surveillance pathway_Homo sapiens_hsa030151.29365672
51Calcium signaling pathway_Homo sapiens_hsa040201.28762225
52RNA degradation_Homo sapiens_hsa030181.28012353
53Pyruvate metabolism_Homo sapiens_hsa006201.25844869
54Parkinsons disease_Homo sapiens_hsa050121.25565605
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23357530
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23187426
57Oocyte meiosis_Homo sapiens_hsa041141.22279872
58One carbon pool by folate_Homo sapiens_hsa006701.16669431
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16586615
60Carbon metabolism_Homo sapiens_hsa012001.15970411
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13599935
62RNA polymerase_Homo sapiens_hsa030201.12644397
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11916387
64Melanogenesis_Homo sapiens_hsa049161.11514746
65Oxytocin signaling pathway_Homo sapiens_hsa049211.09709218
66Cocaine addiction_Homo sapiens_hsa050301.09477255
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06063155
68Cell cycle_Homo sapiens_hsa041101.05693892
69Proteasome_Homo sapiens_hsa030501.04549928
70Mismatch repair_Homo sapiens_hsa034301.02072424
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01330240
72Cardiac muscle contraction_Homo sapiens_hsa042601.00990007
73Wnt signaling pathway_Homo sapiens_hsa043101.00260225
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98892043
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94533297
76Vibrio cholerae infection_Homo sapiens_hsa051100.93897481
77Fanconi anemia pathway_Homo sapiens_hsa034600.93823483
78Butanoate metabolism_Homo sapiens_hsa006500.93078205
79DNA replication_Homo sapiens_hsa030300.91803192
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86476114
81Axon guidance_Homo sapiens_hsa043600.85194410
82Circadian rhythm_Homo sapiens_hsa047100.84997744
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.84415462
84Hippo signaling pathway_Homo sapiens_hsa043900.83023408
85Estrogen signaling pathway_Homo sapiens_hsa049150.82494075
86Vitamin B6 metabolism_Homo sapiens_hsa007500.81054054
87Nucleotide excision repair_Homo sapiens_hsa034200.79423620
88Sulfur relay system_Homo sapiens_hsa041220.77650284
89Homologous recombination_Homo sapiens_hsa034400.76965612
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76940740
91Thyroid hormone synthesis_Homo sapiens_hsa049180.76469369
92Basal cell carcinoma_Homo sapiens_hsa052170.74726008
93cAMP signaling pathway_Homo sapiens_hsa040240.74214920
94Purine metabolism_Homo sapiens_hsa002300.74029747
95Inositol phosphate metabolism_Homo sapiens_hsa005620.73782844
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73527707
97Ribosome_Homo sapiens_hsa030100.71436474
98p53 signaling pathway_Homo sapiens_hsa041150.71404932
99Selenocompound metabolism_Homo sapiens_hsa004500.71003852
100Ether lipid metabolism_Homo sapiens_hsa005650.70570010
101Glucagon signaling pathway_Homo sapiens_hsa049220.70086630
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68342476
103Folate biosynthesis_Homo sapiens_hsa007900.67827364
104Fatty acid metabolism_Homo sapiens_hsa012120.65351282
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65319749
106Pancreatic secretion_Homo sapiens_hsa049720.64073984
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63843367
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63713405
109Ovarian steroidogenesis_Homo sapiens_hsa049130.62956699
110Glutathione metabolism_Homo sapiens_hsa004800.62881304
111Alcoholism_Homo sapiens_hsa050340.62659233
112Metabolic pathways_Homo sapiens_hsa011000.62110580
113Rheumatoid arthritis_Homo sapiens_hsa053230.61723023
114ErbB signaling pathway_Homo sapiens_hsa040120.60625850
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60343905
116beta-Alanine metabolism_Homo sapiens_hsa004100.60281767
117Regulation of autophagy_Homo sapiens_hsa041400.57369046
118Colorectal cancer_Homo sapiens_hsa052100.56300694
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.55093182
120Pyrimidine metabolism_Homo sapiens_hsa002400.54270495
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53994004
122Peroxisome_Homo sapiens_hsa041460.52900797
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.51869380
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51270029
125TGF-beta signaling pathway_Homo sapiens_hsa043500.51031009
126N-Glycan biosynthesis_Homo sapiens_hsa005100.48850291
127Hedgehog signaling pathway_Homo sapiens_hsa043400.47639261
128Arginine and proline metabolism_Homo sapiens_hsa003300.47331626
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45075600
130Phagosome_Homo sapiens_hsa041450.44485216
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44275497
132Protein export_Homo sapiens_hsa030600.44030547
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43645375
134Ras signaling pathway_Homo sapiens_hsa040140.42745395
135MAPK signaling pathway_Homo sapiens_hsa040100.41577609
136Base excision repair_Homo sapiens_hsa034100.41138793
137Lysine degradation_Homo sapiens_hsa003100.38490993
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37749169
139Melanoma_Homo sapiens_hsa052180.36662124
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34795234
141Pentose phosphate pathway_Homo sapiens_hsa000300.34419150
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32647416
143Rap1 signaling pathway_Homo sapiens_hsa040150.32319870
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31862840
145Glioma_Homo sapiens_hsa052140.30993345
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30757274
147Prolactin signaling pathway_Homo sapiens_hsa049170.30404379
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30010416
149Adherens junction_Homo sapiens_hsa045200.28954792
150Endometrial cancer_Homo sapiens_hsa052130.28727755
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26859835
152Dorso-ventral axis formation_Homo sapiens_hsa043200.26675953
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25836934

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