TPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of leukocyte degranulation (GO:0043302)9.90648786
2regulation of podosome assembly (GO:0071801)9.52689921
3positive regulation of granulocyte differentiation (GO:0030854)9.13753791
4tyrosine phosphorylation of STAT protein (GO:0007260)8.60367023
5positive regulation of chemokine secretion (GO:0090197)8.59852554
6regulation of acute inflammatory response to antigenic stimulus (GO:0002864)8.32874467
7behavioral response to nicotine (GO:0035095)8.30927421
8positive regulation of inflammatory response to antigenic stimulus (GO:0002863)7.94423421
9positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)7.85799341
10signal peptide processing (GO:0006465)7.60171813
11regulation of mast cell degranulation (GO:0043304)7.34767285
12positive regulation of regulated secretory pathway (GO:1903307)7.17153788
13regulation of proton transport (GO:0010155)7.09305169
14leukotriene biosynthetic process (GO:0019370)7.02976681
15regulation of chemokine secretion (GO:0090196)6.94040084
16regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)6.92549121
17regulation of mast cell activation involved in immune response (GO:0033006)6.92297643
18positive regulation of megakaryocyte differentiation (GO:0045654)6.87676728
19production of molecular mediator involved in inflammatory response (GO:0002532)6.68330076
20peptide hormone processing (GO:0016486)6.42552188
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)6.27956562
22positive regulation of immunoglobulin production (GO:0002639)6.27893372
23positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)6.04175621
24regulation of immunoglobulin secretion (GO:0051023)6.00441451
25regulation of myeloid leukocyte mediated immunity (GO:0002886)5.67088267
26regulation of transforming growth factor beta production (GO:0071634)5.65065973
27regulation of granulocyte differentiation (GO:0030852)5.56884453
28regulation of leukocyte degranulation (GO:0043300)5.47011019
29regulation of transforming growth factor beta1 production (GO:0032908)5.39560930
30regulation of macrophage activation (GO:0043030)5.22572571
31regulation of mast cell activation (GO:0033003)5.20118352
32inositol phosphate-mediated signaling (GO:0048016)5.02140884
33positive regulation of B cell proliferation (GO:0030890)4.84981001
34regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.75719237
35regulation of regulated secretory pathway (GO:1903305)4.64172912
36positive regulation of acute inflammatory response (GO:0002675)4.62997639
37negative regulation of meiosis (GO:0045835)4.58482382
38regulation of immunoglobulin production (GO:0002637)4.42995134
39negative regulation of appetite (GO:0032099)4.39210853
40negative regulation of response to food (GO:0032096)4.39210853
41leukotriene metabolic process (GO:0006691)4.35031573
42water-soluble vitamin biosynthetic process (GO:0042364)4.31676723
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.18928449
44regulation of inflammatory response to antigenic stimulus (GO:0002861)4.18109853
45positive regulation of macrophage differentiation (GO:0045651)4.14898917
46monoamine transport (GO:0015844)4.14004903
47cytokine biosynthetic process (GO:0042089)3.96475298
48viral protein processing (GO:0019082)3.94806210
49membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.87773981
50negative regulation of transcription regulatory region DNA binding (GO:2000678)3.86946765
51cytokine metabolic process (GO:0042107)3.86436028
52positive regulation of organelle assembly (GO:1902117)3.86067962
53positive regulation of JAK-STAT cascade (GO:0046427)3.76802303
54membrane repolarization during action potential (GO:0086011)3.74304193
55mast cell degranulation (GO:0043303)3.73971159
56mast cell activation involved in immune response (GO:0002279)3.73971159
57regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.70588918
58positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.70588918
59positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.66915894
60protein carboxylation (GO:0018214)3.66071767
61peptidyl-glutamic acid carboxylation (GO:0017187)3.66071767
62cell proliferation in forebrain (GO:0021846)3.64848248
63regulation of B cell proliferation (GO:0030888)3.61457547
64tolerance induction (GO:0002507)3.58011449
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.50192380
66positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.46014228
67thrombin receptor signaling pathway (GO:0070493)3.43209538
68protein complex biogenesis (GO:0070271)3.42451617
69positive regulation of B cell mediated immunity (GO:0002714)3.41881369
70positive regulation of immunoglobulin mediated immune response (GO:0002891)3.41881369
71positive regulation of fatty acid oxidation (GO:0046321)3.41600510
72gamma-aminobutyric acid transport (GO:0015812)3.36456624
73actin nucleation (GO:0045010)3.34404686
74positive regulation of B cell activation (GO:0050871)3.32712577
75positive regulation of production of molecular mediator of immune response (GO:0002702)3.31420429
76cytokine production involved in immune response (GO:0002367)3.28189197
77lung lobe morphogenesis (GO:0060463)3.25744398
78mast cell activation (GO:0045576)3.25237213
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.24758689
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.24234181
81positive regulation of Rho protein signal transduction (GO:0035025)3.23850777
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.21933058
83transmission of nerve impulse (GO:0019226)3.21777177
84protein polyglutamylation (GO:0018095)3.21073106
85pyrimidine nucleobase catabolic process (GO:0006208)3.18824130
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17786361
87parturition (GO:0007567)3.11725203
88positive regulation of calcium-mediated signaling (GO:0050850)3.10570401
89negative regulation of blood pressure (GO:0045776)3.10367280
90negative regulation of calcium ion transport into cytosol (GO:0010523)3.09850584
91retinal ganglion cell axon guidance (GO:0031290)3.08666298
92regulation of response to food (GO:0032095)3.07063235
93regulation of appetite (GO:0032098)3.05994406
94magnesium ion transport (GO:0015693)3.05318842
95positive regulation of myeloid leukocyte differentiation (GO:0002763)3.04442681
96negative regulation of systemic arterial blood pressure (GO:0003085)3.04305290
97mitochondrial respiratory chain complex assembly (GO:0033108)3.03989836
98nonmotile primary cilium assembly (GO:0035058)3.03489295
99kidney morphogenesis (GO:0060993)3.03399154
100NADH dehydrogenase complex assembly (GO:0010257)3.02227579
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02227579
102mitochondrial respiratory chain complex I assembly (GO:0032981)3.02227579
103G-protein coupled receptor internalization (GO:0002031)2.99680695
104positive regulation of myeloid cell differentiation (GO:0045639)2.97359288
105regulation of JAK-STAT cascade (GO:0046425)2.94246870
106regulation of macrophage differentiation (GO:0045649)2.94073868
107epithelial cilium movement (GO:0003351)2.93859278
108detection of light stimulus involved in sensory perception (GO:0050962)2.93293357
109detection of light stimulus involved in visual perception (GO:0050908)2.93293357
110somite development (GO:0061053)2.91570813
111positive regulation of exocytosis (GO:0045921)2.91435835
112muscle organ morphogenesis (GO:0048644)2.90160586
113negative regulation of meiotic cell cycle (GO:0051447)2.89436863
114sulfation (GO:0051923)2.88616365
115fucose catabolic process (GO:0019317)2.88206663
116L-fucose metabolic process (GO:0042354)2.88206663
117L-fucose catabolic process (GO:0042355)2.88206663
118regulation of megakaryocyte differentiation (GO:0045652)2.87126038
119icosanoid biosynthetic process (GO:0046456)2.85884712
120fatty acid derivative biosynthetic process (GO:1901570)2.85884712
121axoneme assembly (GO:0035082)2.84160202
122membrane depolarization during action potential (GO:0086010)2.83964255
123nucleobase catabolic process (GO:0046113)2.83867221
124regulation of mesoderm development (GO:2000380)2.83645190
125negative regulation of membrane potential (GO:0045837)2.83584395
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83454703
127synaptic transmission, cholinergic (GO:0007271)2.82355412
128membrane repolarization (GO:0086009)2.81418400
129tryptophan catabolic process (GO:0006569)2.81380234
130indole-containing compound catabolic process (GO:0042436)2.81380234
131indolalkylamine catabolic process (GO:0046218)2.81380234
132tooth mineralization (GO:0034505)2.81373433
133positive regulation of calcium ion transport into cytosol (GO:0010524)2.79986025
134regulation of action potential (GO:0098900)2.79695523
135* indolalkylamine metabolic process (GO:0006586)2.79661627
136dentate gyrus development (GO:0021542)2.78435647
137virion assembly (GO:0019068)2.78403611
138kynurenine metabolic process (GO:0070189)2.77271066
139dendritic spine morphogenesis (GO:0060997)2.76074466
140limb development (GO:0060173)2.75489500
141appendage development (GO:0048736)2.75489500
142positive regulation of astrocyte differentiation (GO:0048711)2.74211216
143T cell migration (GO:0072678)2.72028943
144regulation of membrane repolarization (GO:0060306)2.70241500
145activation of phospholipase C activity (GO:0007202)2.68362305
146negative regulation of neurological system process (GO:0031645)2.68329048
147cornea development in camera-type eye (GO:0061303)2.66018853
148spinal cord motor neuron differentiation (GO:0021522)2.64752965
149otic vesicle formation (GO:0030916)2.64113841
150negative regulation of T cell differentiation in thymus (GO:0033085)2.64067488
151lung vasculature development (GO:0060426)2.63588466
152cellular anion homeostasis (GO:0030002)2.63525602
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61617573
154reflex (GO:0060004)2.60723881
155regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.60690107
156lipoxygenase pathway (GO:0019372)2.60597530
157positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.60276435
158cilium movement (GO:0003341)2.59836275
159neuronal action potential (GO:0019228)2.58620830
160regulation of interleukin-5 production (GO:0032674)2.55243151
161regulation of B cell mediated immunity (GO:0002712)2.55241725
162glycerophospholipid catabolic process (GO:0046475)2.54780688
163detection of temperature stimulus involved in sensory perception (GO:0050961)2.54730615
164detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.54730615
165lung secretory cell differentiation (GO:0061140)2.54498591
166regulation of cilium movement (GO:0003352)2.54052653
167multicellular organismal signaling (GO:0035637)2.53093869
168regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.52996570
169negative regulation of bone resorption (GO:0045779)2.52304706
170regulation of transcription regulatory region DNA binding (GO:2000677)2.52299665
171regulation of T-helper 1 type immune response (GO:0002825)2.51840751
172presynaptic membrane organization (GO:0097090)2.50217157
173regulation of sequestering of triglyceride (GO:0010889)2.49809144
174cytochrome complex assembly (GO:0017004)2.49777542
175DNA deamination (GO:0045006)2.49064206
176regulation of DNA endoreduplication (GO:0032875)2.46645497
177positive regulation of fatty acid transport (GO:2000193)2.45409234
178pharyngeal system development (GO:0060037)2.44713451
179regulation of neurotransmitter uptake (GO:0051580)2.44042903
180positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.43529277
181cellular response to ATP (GO:0071318)2.42837070
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42446691
183purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42446691
184nephron tubule morphogenesis (GO:0072078)2.41851031
185nephron epithelium morphogenesis (GO:0072088)2.41851031
186regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41442334
187calcium ion import (GO:0070509)2.40846179
188presynaptic membrane assembly (GO:0097105)2.39712335
189cell differentiation in spinal cord (GO:0021515)2.37686798
190piRNA metabolic process (GO:0034587)2.37181507
191neuron fate determination (GO:0048664)2.36357249
192negative regulation of response to extracellular stimulus (GO:0032105)2.33467140
193negative regulation of response to nutrient levels (GO:0032108)2.33467140
194positive regulation of mast cell activation involved in immune response (GO:0033008)13.1462040
195positive regulation of mast cell degranulation (GO:0043306)13.1462040
196angiotensin maturation (GO:0002003)12.9894955
197positive regulation of macrophage activation (GO:0043032)12.5869185
198regulation of hypersensitivity (GO:0002883)12.1546740
199positive regulation of mast cell activation (GO:0033005)10.8401481
200positive regulation of myeloid leukocyte mediated immunity (GO:0002888)10.7478439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57430978
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05441855
3SCL_19346495_ChIP-Seq_HPC-7_Human3.76349305
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.59483006
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.99985075
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97116754
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.92284755
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90465474
9RUNX_20019798_ChIP-Seq_JUKART_Human2.88892122
10ZNF274_21170338_ChIP-Seq_K562_Hela2.79086931
11EGR1_19032775_ChIP-ChIP_M12_Human2.72647208
12RUNX1_22412390_ChIP-Seq_EML_Mouse2.70658070
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.53923264
14VDR_22108803_ChIP-Seq_LS180_Human2.53223243
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52119182
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.51046057
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47580518
18GATA1_19941826_ChIP-Seq_K562_Human2.47492675
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46781441
20GBX2_23144817_ChIP-Seq_PC3_Human2.46659388
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39275084
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37986973
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35644098
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31603840
25E2F7_22180533_ChIP-Seq_HELA_Human2.28853296
26MAF_26560356_Chip-Seq_TH1_Human2.18697723
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.18653422
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17755697
29MYB_26560356_Chip-Seq_TH2_Human2.08652112
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.08072790
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08072737
32TCF7_22412390_ChIP-Seq_EML_Mouse2.07675679
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.03519623
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.01638631
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.01442702
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.01063219
37JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00974821
38BP1_19119308_ChIP-ChIP_Hs578T_Human11.0979804
39GATA2_22383799_ChIP-Seq_G1ME_Mouse1.95094801
40GATA3_26560356_Chip-Seq_TH2_Human1.93439348
41IRF1_19129219_ChIP-ChIP_H3396_Human1.93358141
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89196889
43IGF1R_20145208_ChIP-Seq_DFB_Human1.88781424
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.85599789
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84094015
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82901180
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82642373
48VDR_24763502_ChIP-Seq_THP-1_Human1.82401937
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81762973
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.77044862
51TAF15_26573619_Chip-Seq_HEK293_Human1.72509021
52VDR_21846776_ChIP-Seq_THP-1_Human1.72473281
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.71082718
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70844026
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65435670
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65399446
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62663985
58P300_19829295_ChIP-Seq_ESCs_Human1.61999309
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60687383
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.60534910
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60364876
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59953431
63RNF2_27304074_Chip-Seq_NSC_Mouse1.58577049
64KDM2B_26808549_Chip-Seq_DND41_Human1.58274210
65FUS_26573619_Chip-Seq_HEK293_Human1.56748385
66GATA2_19941826_ChIP-Seq_K562_Human1.55635810
67EWS_26573619_Chip-Seq_HEK293_Human1.53409007
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49200918
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.49003397
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48979462
71UTX_26944678_Chip-Seq_JUKART_Human1.48845695
72DROSHA_22980978_ChIP-Seq_HELA_Human1.48750105
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48296955
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46496208
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46248601
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46121316
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46121316
78MYB_26560356_Chip-Seq_TH1_Human1.46121293
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46054239
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44450696
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43389478
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43322672
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.41951902
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41096488
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39435783
86MYC_22102868_ChIP-Seq_BL_Human1.37463141
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.36087817
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35172412
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34868139
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34118337
91STAT3_23295773_ChIP-Seq_U87_Human1.32582790
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32508226
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32441887
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32441887
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32245930
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31263668
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30502400
98SMAD4_21799915_ChIP-Seq_A2780_Human1.30055952
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29994110
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29979355
101SPI1_23547873_ChIP-Seq_NB4_Human1.29814050
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28712012
103ER_23166858_ChIP-Seq_MCF-7_Human1.27655422
104CBP_20019798_ChIP-Seq_JUKART_Human1.27410402
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27410402
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.27133684
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26629555
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26019200
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25328329
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.25140461
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24793946
112MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24286509
113TP53_22573176_ChIP-Seq_HFKS_Human1.24122901
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23844687
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23748390
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23570552
117TCF4_23295773_ChIP-Seq_U87_Human1.22577660
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22409907
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22223876
120AR_25329375_ChIP-Seq_VCAP_Human1.20335210
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20191774
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18862949
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.17623952
124* NCOR_22424771_ChIP-Seq_293T_Human1.17572055
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17510785
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17136659
127SPI1_23127762_ChIP-Seq_K562_Human1.16703758
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16316106
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15821798
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15404287
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15317797
132KDM2B_26808549_Chip-Seq_JURKAT_Human1.15151046
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.13538250
134BCAT_22108803_ChIP-Seq_LS180_Human1.13075849
135LXR_22292898_ChIP-Seq_THP-1_Human1.13055430
136GATA3_27048872_Chip-Seq_THYMUS_Human1.12784194
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09959753
138NCOR1_26117541_ChIP-Seq_K562_Human1.08802574
139P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06438659
140KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06406269
141ESR2_21235772_ChIP-Seq_MCF-7_Human1.05973885
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05569629
143IRF8_27001747_Chip-Seq_BMDM_Mouse1.03366155
144RUNX2_22187159_ChIP-Seq_PCA_Human1.03161798
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02177518
146NANOG_19829295_ChIP-Seq_ESCs_Human1.01753941
147SOX2_19829295_ChIP-Seq_ESCs_Human1.01753941
148VDR_24787735_ChIP-Seq_THP-1_Human1.01159990
149MAF_26560356_Chip-Seq_TH2_Human1.01095640
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.00735466
151SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00349086
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00121213
153* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99981367
154* GATA3_21878914_ChIP-Seq_MCF-7_Human0.99852326
155* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99542825
156* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99542825
157SOX2_21211035_ChIP-Seq_LN229_Gbm0.98865346
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.98710010
159NFE2_27457419_Chip-Seq_LIVER_Mouse0.98261357
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98027773
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97067330
162POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96759339
163* TCF4_22108803_ChIP-Seq_LS180_Human0.96750672
164MYC_19829295_ChIP-Seq_ESCs_Human0.96569451
165CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96288918
166GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96044454
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95893457
168KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95673754
169NANOG_18555785_Chip-Seq_ESCs_Mouse0.95079747
170SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94260329
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93853718
172FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91568265
173VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90946643
174STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90840148
175GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90309369
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90298375
177TP53_16413492_ChIP-PET_HCT116_Human0.87688028
178CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86254340
179NANOG_20526341_ChIP-Seq_ESCs_Human0.85191309
180SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83565946
181ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83009207
182KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82621235
183PU_27001747_Chip-Seq_BMDM_Mouse0.81903372
184MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81687299
185* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81425209
186TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81109936
187GATA1_22025678_ChIP-Seq_K562_Human0.80223400
188ERG_21242973_ChIP-ChIP_JURKAT_Human0.78278280
189TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76618305
190ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76344837
191E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76254273
192CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75884677
193GATA3_26560356_Chip-Seq_TH1_Human0.74839337
194GATA6_25053715_ChIP-Seq_YYC3_Human0.74021920
195ZFP281_27345836_Chip-Seq_ESCs_Mouse0.73392381
196ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71841325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003045_fibrosis6.69620081
2MP0002877_abnormal_melanocyte_morpholog4.28264424
3MP0003646_muscle_fatigue4.06435659
4MP0005671_abnormal_response_to3.64965719
5MP0002837_dystrophic_cardiac_calcinosis3.60945109
6MP0003638_abnormal_response/metabolism_3.48145928
7MP0003300_gastrointestinal_ulcer3.37794875
8MP0005387_immune_system_phenotype3.35870369
9MP0001790_abnormal_immune_system3.35870369
10MP0000465_gastrointestinal_hemorrhage3.34255449
11MP0004510_myositis2.93557352
12MP0001800_abnormal_humoral_immune2.83381048
13MP0001835_abnormal_antigen_presentation2.75621596
14MP0002909_abnormal_adrenal_gland2.67747218
15MP0005025_abnormal_response_to2.66564638
16MP0006292_abnormal_olfactory_placode2.63289400
17MP0006276_abnormal_autonomic_nervous2.56354242
18MP0003866_abnormal_defecation2.55660686
19MP0005000_abnormal_immune_tolerance2.53847999
20MP0003436_decreased_susceptibility_to2.50989509
21MP0005166_decreased_susceptibility_to2.44094274
22MP0003724_increased_susceptibility_to2.42999009
23MP0001819_abnormal_immune_cell2.32344990
24MP0002420_abnormal_adaptive_immunity2.32154449
25MP0005464_abnormal_platelet_physiology2.30409496
26MP0002168_other_aberrant_phenotype2.26569655
27MP0004808_abnormal_hematopoietic_stem2.25875322
28MP0002148_abnormal_hypersensitivity_rea2.25485285
29MP0002723_abnormal_immune_serum2.13499918
30MP0002398_abnormal_bone_marrow2.10223622
31MP0002735_abnormal_chemical_nociception2.10066308
32MP0002160_abnormal_reproductive_system2.02647158
33MP0008877_abnormal_DNA_methylation1.97759204
34MP0005551_abnormal_eye_electrophysiolog1.95285990
35MP0005623_abnormal_meninges_morphology1.94727498
36MP0001485_abnormal_pinna_reflex1.93057094
37MP0003303_peritoneal_inflammation1.93032625
38MP0006072_abnormal_retinal_apoptosis1.92639533
39MP0009745_abnormal_behavioral_response1.86958194
40MP0005310_abnormal_salivary_gland1.86455664
41MP0002452_abnormal_antigen_presenting1.86062982
42MP0003011_delayed_dark_adaptation1.84725743
43MP0002876_abnormal_thyroid_physiology1.82269913
44MP0002272_abnormal_nervous_system1.81363471
45MP0002419_abnormal_innate_immunity1.80876061
46MP0001968_abnormal_touch/_nociception1.78339757
47MP0009765_abnormal_xenobiotic_induced1.77689869
48MP0004130_abnormal_muscle_cell1.77548482
49MP0004145_abnormal_muscle_electrophysio1.76813769
50MP0000631_abnormal_neuroendocrine_gland1.76614899
51MP0004133_heterotaxia1.70463839
52MP0003566_abnormal_cell_adhesion1.66466918
53MP0003195_calcinosis1.65950284
54MP0002638_abnormal_pupillary_reflex1.65889857
55MP0009379_abnormal_foot_pigmentation1.64973091
56MP0004947_skin_inflammation1.63585150
57MP0000716_abnormal_immune_system1.63399155
58MP0009046_muscle_twitch1.61812213
59MP0003787_abnormal_imprinting1.58004392
60MP0000477_abnormal_intestine_morphology1.57943166
61MP0003122_maternal_imprinting1.56858192
62MP0003879_abnormal_hair_cell1.55707360
63MP0005389_reproductive_system_phenotype1.54915785
64MP0002653_abnormal_ependyma_morphology1.53129866
65MP0002163_abnormal_gland_morphology1.51725227
66MP0002429_abnormal_blood_cell1.50346568
67MP0003880_abnormal_central_pattern1.50305015
68MP0004142_abnormal_muscle_tone1.50300162
69MP0002722_abnormal_immune_system1.48547969
70MP0001845_abnormal_inflammatory_respons1.47929715
71MP0005423_abnormal_somatic_nervous1.44009568
72MP0004742_abnormal_vestibular_system1.43526665
73MP0006082_CNS_inflammation1.43194729
74MP0004264_abnormal_extraembryonic_tissu1.42845750
75MP0005076_abnormal_cell_differentiation1.42511794
76MP0000026_abnormal_inner_ear1.41891923
77MP0000230_abnormal_systemic_arterial1.39299756
78MP0001533_abnormal_skeleton_physiology1.37091897
79MP0002938_white_spotting1.37026349
80MP0002184_abnormal_innervation1.35760056
81MP0008789_abnormal_olfactory_epithelium1.35643294
82MP0002736_abnormal_nociception_after1.34764895
83MP0000049_abnormal_middle_ear1.33957327
84MP0001486_abnormal_startle_reflex1.30545012
85MP0002064_seizures1.30319346
86MP0010386_abnormal_urinary_bladder1.29414166
87MP0002102_abnormal_ear_morphology1.28183260
88MP0001727_abnormal_embryo_implantation1.27819384
89MP0001440_abnormal_grooming_behavior1.27814284
90MP0008872_abnormal_physiological_respon1.26139702
91MP0008469_abnormal_protein_level1.26050695
92MP0010155_abnormal_intestine_physiology1.25923490
93MP0003121_genomic_imprinting1.25844138
94MP0001188_hyperpigmentation1.25463118
95MP0009333_abnormal_splenocyte_physiolog1.25396906
96MP0001873_stomach_inflammation1.24566833
97MP0002396_abnormal_hematopoietic_system1.23192398
98MP0010234_abnormal_vibrissa_follicle1.22522228
99MP0001542_abnormal_bone_strength1.21574886
100* MP0002572_abnormal_emotion/affect_behav1.21520011
101MP0004215_abnormal_myocardial_fiber1.21486053
102MP0010307_abnormal_tumor_latency1.21160652
103MP0000703_abnormal_thymus_morphology1.19383771
104MP0002405_respiratory_system_inflammati1.19097683
105MP0005379_endocrine/exocrine_gland_phen1.17700671
106MP0005253_abnormal_eye_physiology1.17082639
107MP0005084_abnormal_gallbladder_morpholo1.16984924
108MP0002734_abnormal_mechanical_nocicepti1.15571740
109* MP0001970_abnormal_pain_threshold1.15276547
110MP0001963_abnormal_hearing_physiology1.13813036
111MP0001501_abnormal_sleep_pattern1.13488273
112MP0002752_abnormal_somatic_nervous1.11439897
113MP0000778_abnormal_nervous_system1.10905462
114MP0003635_abnormal_synaptic_transmissio1.10438881
115MP0001905_abnormal_dopamine_level1.09357141
116MP0000249_abnormal_blood_vessel1.08045106
117MP0001986_abnormal_taste_sensitivity1.07253323
118MP0002822_catalepsy1.05861507
119MP0002063_abnormal_learning/memory/cond1.05596590
120MP0001502_abnormal_circadian_rhythm1.05371187
121MP0009785_altered_susceptibility_to1.04472336
122MP0002928_abnormal_bile_duct1.04299994
123MP0005195_abnormal_posterior_eye1.04129322
124MP0004147_increased_porphyrin_level1.03973676
125MP0002998_abnormal_bone_remodeling1.03832788
126MP0000685_abnormal_immune_system1.03810921
127MP0005448_abnormal_energy_balance1.02577383
128MP0003123_paternal_imprinting1.02484990
129MP0010329_abnormal_lipoprotein_level1.02349902
130MP0003119_abnormal_digestive_system1.00534201
131MP0000372_irregular_coat_pigmentation1.00106329
132MP0001984_abnormal_olfaction0.99467495
133MP0003938_abnormal_ear_development0.99207476
134MP0008873_increased_physiological_sensi0.99207098
135MP0001851_eye_inflammation0.99160493
136MP0003890_abnormal_embryonic-extraembry0.99013630
137MP0002067_abnormal_sensory_capabilities0.97931463
138MP0004019_abnormal_vitamin_homeostasis0.97824630
139* MP0004085_abnormal_heartbeat0.96040510
140MP0008875_abnormal_xenobiotic_pharmacok0.95384471
141MP0005395_other_phenotype0.95012591
142MP0001881_abnormal_mammary_gland0.94823487
143* MP0002733_abnormal_thermal_nociception0.93729612
144MP0004043_abnormal_pH_regulation0.92996075
145MP0008770_decreased_survivor_rate0.92944858
146MP0001919_abnormal_reproductive_system0.92826110
147MP0002277_abnormal_respiratory_mucosa0.90127683
148MP0000427_abnormal_hair_cycle0.89574081
149MP0005394_taste/olfaction_phenotype0.89320376
150MP0005499_abnormal_olfactory_system0.89320376
151MP0002229_neurodegeneration0.88763573
152* MP0008775_abnormal_heart_ventricle0.88632398
153MP0005332_abnormal_amino_acid0.88197611
154MP0009763_increased_sensitivity_to0.86216718
155MP0009780_abnormal_chondrocyte_physiolo0.85896791
156MP0002693_abnormal_pancreas_physiology0.85611232
157MP0000516_abnormal_urinary_system0.84908423
158MP0005367_renal/urinary_system_phenotyp0.84908423
159MP0002882_abnormal_neuron_morphology0.83592236
160MP0000490_abnormal_crypts_of0.83408300
161MP0003942_abnormal_urinary_system0.83392175
162MP0001853_heart_inflammation0.82335258
163MP0003283_abnormal_digestive_organ0.81873951
164MP0001765_abnormal_ion_homeostasis0.78677253
165MP0000689_abnormal_spleen_morphology0.74782976
166MP0003795_abnormal_bone_structure0.74192179
167MP0005390_skeleton_phenotype0.70721225
168MP0005646_abnormal_pituitary_gland0.70220290
169MP0005174_abnormal_tail_pigmentation0.70067300
170MP0005248_abnormal_Harderian_gland0.68862169
171MP0002933_joint_inflammation0.68119664
172MP0004885_abnormal_endolymph0.65746761
173MP0001663_abnormal_digestive_system0.62039788
174MP0002254_reproductive_system_inflammat0.60730823
175MP0003172_abnormal_lysosome_physiology0.56355188
176MP0002086_abnormal_extraembryonic_tissu0.54812840
177MP0000639_abnormal_adrenal_gland0.52863265
178MP0005645_abnormal_hypothalamus_physiol0.52741936
179MP0003763_abnormal_thymus_physiology0.52451107
180MP0004185_abnormal_adipocyte_glucose0.51191676
181MP0006054_spinal_hemorrhage0.49216937
182MP0000858_altered_metastatic_potential0.48979824
183MP0005075_abnormal_melanosome_morpholog0.46629752
184MP0002557_abnormal_social/conspecific_i0.45151516
185MP0004858_abnormal_nervous_system0.43020219
186MP0001849_ear_inflammation0.41763819
187MP0003448_altered_tumor_morphology0.41583594

Predicted human phenotypes

RankGene SetZ-score
1Purpura (HP:0000979)8.02587404
2Abnormal platelet volume (HP:0011876)7.96404928
3Increased mean platelet volume (HP:0011877)7.91135425
4Menorrhagia (HP:0000132)7.75030165
5Gingival bleeding (HP:0000225)7.59174112
6Prolonged bleeding time (HP:0003010)7.44696087
7Abnormal platelet function (HP:0011869)6.86930799
8Impaired platelet aggregation (HP:0003540)6.86930799
9IgM deficiency (HP:0002850)5.20702427
10Epistaxis (HP:0000421)4.17406131
11Papilledema (HP:0001085)4.13881519
12Pancreatic cysts (HP:0001737)3.89387241
13Chronic otitis media (HP:0000389)3.69758377
14Sex reversal (HP:0012245)3.63062358
15Abnormal sex determination (HP:0012244)3.63062358
16Pancreatic fibrosis (HP:0100732)3.56682284
17Decreased circulating renin level (HP:0003351)3.45226759
18Abnormality of midbrain morphology (HP:0002418)3.41883185
19Molar tooth sign on MRI (HP:0002419)3.41883185
20Gastrointestinal stroma tumor (HP:0100723)3.40144556
21Congenital stationary night blindness (HP:0007642)3.32532087
22True hermaphroditism (HP:0010459)3.32369907
23Nephronophthisis (HP:0000090)3.31087015
24Progressive cerebellar ataxia (HP:0002073)3.18959756
25Aplasia/Hypoplasia of the tibia (HP:0005772)3.11072232
26B lymphocytopenia (HP:0010976)3.08394425
27Abnormality of B cell number (HP:0010975)3.08394425
28Abnormality of binocular vision (HP:0011514)3.07154037
29Diplopia (HP:0000651)3.07154037
30Type II lissencephaly (HP:0007260)3.04345894
31Recurrent bronchitis (HP:0002837)2.93946051
32Abolished electroretinogram (ERG) (HP:0000550)2.92692946
33Short tibia (HP:0005736)2.90269388
34Recurrent fungal infections (HP:0002841)2.85894344
35Abnormality of the renal medulla (HP:0100957)2.83619774
36Aplastic anemia (HP:0001915)2.81129744
37Bruising susceptibility (HP:0000978)2.75361630
38Recurrent viral infections (HP:0004429)2.68586300
39Genetic anticipation (HP:0003743)2.66723801
40Medial flaring of the eyebrow (HP:0010747)2.63124525
41Pendular nystagmus (HP:0012043)2.61577063
42Inflammation of the large intestine (HP:0002037)2.59623627
43Cellulitis (HP:0100658)2.58720531
44Abnormality of T cell physiology (HP:0011840)2.58353093
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.57565866
46Panhypogammaglobulinemia (HP:0003139)2.55724852
47Recurrent bacterial skin infections (HP:0005406)2.51592318
48Cystic liver disease (HP:0006706)2.51378098
49Short 4th metacarpal (HP:0010044)2.50949758
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50949758
51Methylmalonic acidemia (HP:0002912)2.50904723
52Congenital, generalized hypertrichosis (HP:0004540)2.47717131
53Recurrent abscess formation (HP:0002722)2.46767278
54Gastrointestinal inflammation (HP:0004386)2.46258810
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45520400
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45259266
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45193028
58Methylmalonic aciduria (HP:0012120)2.42567929
59Abnormal rod and cone electroretinograms (HP:0008323)2.41994105
60Mesomelia (HP:0003027)2.41449705
61Abnormality of the renal cortex (HP:0011035)2.40346731
62Congenital sensorineural hearing impairment (HP:0008527)2.38584251
63Increased IgE level (HP:0003212)2.38177305
64IgA deficiency (HP:0002720)2.36718989
65Metabolic alkalosis (HP:0200114)2.36369348
66Vacuolated lymphocytes (HP:0001922)2.35203134
67Urinary glycosaminoglycan excretion (HP:0003541)2.33680568
68Mucopolysacchariduria (HP:0008155)2.33680568
69Hypercortisolism (HP:0001578)2.33664777
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.31629729
71Hyperventilation (HP:0002883)2.28185622
72Tubular atrophy (HP:0000092)2.27786142
73Aplasia/hypoplasia of the uterus (HP:0008684)2.23713131
74Decreased central vision (HP:0007663)2.23501631
75Abnormality of the 4th metacarpal (HP:0010012)2.23161426
76Abnormality of liposaccharide metabolism (HP:0010968)2.22436829
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.22436829
78Abnormality of glycolipid metabolism (HP:0010969)2.22436829
79Aplasia/Hypoplasia of the fibula (HP:0006492)2.21100235
80Abnormality of renin-angiotensin system (HP:0000847)2.20669699
81Chronic hepatic failure (HP:0100626)2.18928620
82Abnormal drinking behavior (HP:0030082)2.17445078
83Polydipsia (HP:0001959)2.17445078
84Cervical subluxation (HP:0003308)2.16919308
85Hyperglycinemia (HP:0002154)2.15867262
86Short femoral neck (HP:0100864)2.15389012
87Asplenia (HP:0001746)2.15034491
88Symphalangism affecting the phalanges of the hand (HP:0009773)2.14944038
89Hyperacusis (HP:0010780)2.14046727
90Increased corneal curvature (HP:0100692)2.13447532
91Keratoconus (HP:0000563)2.13447532
92Hypoplasia of the uterus (HP:0000013)2.12293204
93Heterochromia iridis (HP:0001100)2.11831816
94Fibular hypoplasia (HP:0003038)2.11237643
95Hypoplasia of the ulna (HP:0003022)2.10902655
96Clumsiness (HP:0002312)2.10788802
97White forelock (HP:0002211)2.10680587
98Anencephaly (HP:0002323)2.09678347
99Spontaneous hematomas (HP:0007420)2.08769129
100Sclerocornea (HP:0000647)2.08271297
101Abnormal ciliary motility (HP:0012262)2.07160883
102Aplasia/Hypoplasia of the patella (HP:0006498)2.06534627
103Acute myeloid leukemia (HP:0004808)2.06315530
104Insomnia (HP:0100785)2.05830205
105Gait imbalance (HP:0002141)2.04594513
106Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03610012
107Abnormality of T cells (HP:0002843)2.03045626
108Abnormality of polysaccharide metabolism (HP:0011012)2.02956716
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02956716
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02956716
111Abnormal respiratory motile cilium morphology (HP:0005938)2.01810870
112Abnormal respiratory epithelium morphology (HP:0012253)2.01810870
113Eczematoid dermatitis (HP:0000976)2.00984741
114Male pseudohermaphroditism (HP:0000037)2.00587233
115Abnormality of the renal collecting system (HP:0004742)2.00335939
116Petechiae (HP:0000967)11.1763361
117Apathy (HP:0000741)1.99836807
118Patellar aplasia (HP:0006443)1.98766787
119Megalencephaly (HP:0001355)1.98413464
120Abnormality of the middle phalanges of the toes (HP:0010183)1.97893060
121Adrenal overactivity (HP:0002717)1.97336448
122Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96294565
123Vertebral hypoplasia (HP:0008417)1.96294565
124Bony spicule pigmentary retinopathy (HP:0007737)1.95845722
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95468894
126Nasal polyposis (HP:0100582)1.95158086
127Facial shape deformation (HP:0011334)1.94592364
128Potter facies (HP:0002009)1.94592364
129Gaze-evoked nystagmus (HP:0000640)1.93985421
130Severe short stature (HP:0003510)1.93101246
131Abnormality of the phalanges of the 5th finger (HP:0004213)1.93067409
132Congenital primary aphakia (HP:0007707)1.93065125
133Interstitial pulmonary disease (HP:0006530)1.91982516
134Abnormal respiratory motile cilium physiology (HP:0012261)1.91570810
135Stenosis of the external auditory canal (HP:0000402)1.90980795
136Fibular aplasia (HP:0002990)1.88960237
137Slender build (HP:0001533)1.88529302
138Progressive hearing impairment (HP:0001730)1.87129008
139Genital tract atresia (HP:0001827)1.86884957
140Attenuation of retinal blood vessels (HP:0007843)1.86713554
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.85848966
142Absent/shortened dynein arms (HP:0200106)1.85848966
143Cerebellar dysplasia (HP:0007033)1.85506279
144Vaginal atresia (HP:0000148)1.84791720
145Abnormality of alanine metabolism (HP:0010916)1.84754352
146Hyperalaninemia (HP:0003348)1.84754352
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84754352
148Germ cell neoplasia (HP:0100728)1.84078263
149Chorioretinal atrophy (HP:0000533)1.83322367
150Retinal dysplasia (HP:0007973)1.83270642
151Morphological abnormality of the middle ear (HP:0008609)1.82971481
152Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.82630473
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.82400300
154Urticaria (HP:0001025)1.82081951
155Neoplasm of the rectum (HP:0100743)1.81934538
156Abnormality of renal excretion (HP:0011036)1.81732161
157Pachygyria (HP:0001302)1.80651451
158Furrowed tongue (HP:0000221)1.80479341
159Aplasia/Hypoplasia of the ulna (HP:0006495)1.80377562
160Adrenal hypoplasia (HP:0000835)1.80279356
161Concave nail (HP:0001598)1.79171349
162Short hallux (HP:0010109)1.78731178
163Diminished motivation (HP:0000745)1.78518886
164Confusion (HP:0001289)1.77991028
165Colitis (HP:0002583)1.77900071
166Neoplasm of head and neck (HP:0012288)1.77675474
167Esophageal neoplasm (HP:0100751)1.77675474
168Congenital hepatic fibrosis (HP:0002612)1.75975030
169Thyroid-stimulating hormone excess (HP:0002925)1.75725697
170Nephrogenic diabetes insipidus (HP:0009806)1.75626886
171Abnormality of the gastric mucosa (HP:0004295)1.75378792
172Patchy hypopigmentation of hair (HP:0011365)1.74976876
173Poikilocytosis (HP:0004447)1.74890406
174Neoplasm of the peripheral nervous system (HP:0100007)1.74306199
175Agitation (HP:0000713)1.69922049
176Recurrent sinusitis (HP:0011108)1.68071309
177Increased density of long bones (HP:0006392)1.64975873
178Abnormality of oral frenula (HP:0000190)1.62692194
179Vasculitis (HP:0002633)1.62649875
180Neoplasm of the small intestine (HP:0100833)1.61426435
181Supranuclear gaze palsy (HP:0000605)1.61066321
182Hyperaldosteronism (HP:0000859)1.61008120
183Leukocytosis (HP:0001974)1.58770297
184Posterior subcapsular cataract (HP:0007787)1.56316759
185Disproportionate tall stature (HP:0001519)1.53339558
186Chest pain (HP:0100749)1.53296843
187Cerebral aneurysm (HP:0004944)1.53116107
188Bronchitis (HP:0012387)1.52939266
189T lymphocytopenia (HP:0005403)1.51636978
190Recurrent skin infections (HP:0001581)1.50771610
191Hyperparathyroidism (HP:0000843)1.46646851
192Chronic obstructive pulmonary disease (HP:0006510)1.45826703
193Obstructive lung disease (HP:0006536)1.45826703
194Lymphopenia (HP:0001888)1.42870732
195Abnormality of eosinophils (HP:0001879)1.42426856
196Abnormality of the fingertips (HP:0001211)1.42413305
197Progressive neurologic deterioration (HP:0002344)1.41867792
198Abnormality of the nasal mucosa (HP:0000433)1.40958035
199Restrictive lung disease (HP:0002091)1.40759215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.10353848
2TAOK35.60559975
3KIT4.56825282
4MAP4K14.05390795
5FES3.33167194
6TLK13.15226175
7ADRBK23.11640985
8MATK2.84724408
9PINK12.70285114
10EEF2K2.68213160
11GRK12.64120611
12GRK62.51212414
13WNK42.43247822
14TXK2.38347816
15MAP4K22.33207989
16CDK62.31371918
17WNK32.31224764
18TRIB32.25474760
19PKN22.24805412
20ZAK2.24293865
21JAK12.16268750
22CASK2.16226342
23ZAP702.13068598
24BLK2.12771493
25BMPR1B2.02031659
26ACVR1B2.00545608
27ALK1.97166078
28FGFR21.92327095
29MAP3K41.89527952
30SYK1.89031361
31INSRR1.77581728
32RIPK41.68257573
33NUAK11.65311889
34SIK21.64219918
35DYRK21.61531222
36PIK3CA1.60030631
37HIPK21.57104644
38MAPK131.52064990
39TYK21.48299145
40JAK21.48112211
41JAK31.43754737
42STK391.42137207
43NTRK21.41177579
44NTRK31.38366264
45DMPK1.35122612
46SIK11.33398321
47NME11.30698195
48MARK11.27464096
49MAP2K71.24921734
50SGK2231.22824043
51SGK4941.22824043
52PTK61.21344055
53ADRBK11.15811859
54TEC1.15473407
55LYN1.15171079
56BMX1.13433934
57PAK31.12572628
58OXSR11.12300172
59PRKCG1.11053741
60PASK1.09442256
61TNK21.08203238
62TGFBR21.08093272
63EPHB21.07878923
64MAPK151.05778738
65BTK1.04745366
66ITK1.04699154
67TIE11.04005424
68FGFR41.02768639
69PTK21.02732115
70SGK21.02661253
71PRKCE1.01690561
72STK111.01457553
73PHKG11.01415013
74PHKG21.01415013
75MAPKAPK21.00411039
76BCKDK1.00265595
77LRRK20.99764599
78MAPKAPK30.99688657
79HCK0.99396365
80MAPKAPK50.98507571
81PIK3CG0.97094593
82EPHA40.95170532
83STK160.93049516
84EPHB10.91831502
85UHMK10.91703803
86SCYL20.91369131
87RPS6KB20.91029251
88NME20.90718754
89CDK40.85282269
90MAP3K90.84444147
91PIM20.84379518
92STK100.84320549
93MAP2K60.82673711
94LCK0.81533946
95TNIK0.81263629
96PRKD20.81135413
97RPS6KA60.78052755
98ERBB20.76713035
99NEK20.76610384
100STK38L0.75497704
101CAMK1G0.74061197
102PLK20.73275277
103PIM10.72452333
104NEK90.71633193
105PRKCQ0.68828326
106TBK10.68544441
107MKNK20.67640220
108SGK10.67019326
109CSNK1A10.66322643
110PRKCZ0.66121309
111RPS6KA20.65676176
112* PRKACA0.65001948
113CSNK1G20.62567330
114PDK10.62214089
115MINK10.60598527
116CAMK2A0.58965315
117DYRK30.58042466
118MAP2K40.57490685
119MAP2K20.56828317
120MAP3K140.55372168
121IKBKB0.55031410
122PRKACB0.54668428
123CAMK10.54066584
124PRKCB0.53365109
125PRKCA0.52996614
126RPS6KA50.51782650
127SRC0.51353564
128CSNK1G10.50784105
129MUSK0.50263218
130CDK90.50252352
131PRKCI0.50074242
132VRK10.49691774
133CAMKK10.49455029
134FGFR30.48128554
135* PRKACG0.47925962
136TAOK10.45726268
137BRSK20.45589107
138CLK10.45304988
139DYRK1A0.45291357
140ILK0.44747155
141CSNK1G30.44405806
142TGFBR10.43203599
143PDPK10.42403779
144PKN10.40976280
145GRK70.40546259
146CSF1R0.40497772
147NLK0.39563552
148EPHA30.39306196
149PAK20.39186526
150PRKG10.39143808
151PRKG20.38665325
152RET0.37727694
153GRK50.36454723
154MAPK110.36149969
155FYN0.35601712
156FGR0.35042387
157TYRO30.34018847
158OBSCN0.33625369
159CAMK2D0.32936778
160GSK3A0.32724522
161MAPK40.32614453
162PRKCH0.32611649
163PNCK0.32383993
164ABL20.31685970
165DAPK20.31425707
166STK30.30832637
167FGFR10.30801812
168PRKAA10.30257783
169SGK30.29885632
170MAP2K10.27552079
171PDGFRB0.26957845
172IRAK30.25059223
173MAP3K20.25056818
174CAMK1D0.24992611
175TRPM70.24990688
176MAP3K70.24719129
177CAMKK20.24127882
178LIMK10.23892680
179RPS6KL10.23300483
180RPS6KC10.23300483

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046144.99335835
2Allograft rejection_Homo sapiens_hsa053303.65600059
3Fc epsilon RI signaling pathway_Homo sapiens_hsa046643.45748151
4Autoimmune thyroid disease_Homo sapiens_hsa053202.80094682
5Phototransduction_Homo sapiens_hsa047442.67402357
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61495174
7Oxidative phosphorylation_Homo sapiens_hsa001902.58330108
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.54670075
9Nicotine addiction_Homo sapiens_hsa050332.37325081
10Linoleic acid metabolism_Homo sapiens_hsa005912.22776661
11Hematopoietic cell lineage_Homo sapiens_hsa046402.08593018
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04141846
13Asthma_Homo sapiens_hsa0531013.0516822
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94686901
15Parkinsons disease_Homo sapiens_hsa050121.93986776
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88335501
17Cardiac muscle contraction_Homo sapiens_hsa042601.85610810
18Ribosome_Homo sapiens_hsa030101.76718691
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71347197
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.66153472
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62475258
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62340112
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58277114
24Butanoate metabolism_Homo sapiens_hsa006501.57515978
25Caffeine metabolism_Homo sapiens_hsa002321.49188529
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47946370
27* Tryptophan metabolism_Homo sapiens_hsa003801.46706262
28Olfactory transduction_Homo sapiens_hsa047401.45436419
29Taste transduction_Homo sapiens_hsa047421.43458956
30Alzheimers disease_Homo sapiens_hsa050101.42887072
31Retinol metabolism_Homo sapiens_hsa008301.41146014
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39930039
33Chemical carcinogenesis_Homo sapiens_hsa052041.39893418
34Ether lipid metabolism_Homo sapiens_hsa005651.39136362
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38237961
36Circadian entrainment_Homo sapiens_hsa047131.36802064
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35917985
38GABAergic synapse_Homo sapiens_hsa047271.34521885
39Sulfur relay system_Homo sapiens_hsa041221.29346626
40Huntingtons disease_Homo sapiens_hsa050161.28944963
41Glutamatergic synapse_Homo sapiens_hsa047241.28551900
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25580907
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.20665742
44Peroxisome_Homo sapiens_hsa041461.17040224
45Vitamin digestion and absorption_Homo sapiens_hsa049771.14544338
46Glycerolipid metabolism_Homo sapiens_hsa005611.12184616
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08395545
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05808694
49Fat digestion and absorption_Homo sapiens_hsa049751.02263701
50Selenocompound metabolism_Homo sapiens_hsa004501.00530709
51RNA polymerase_Homo sapiens_hsa030201.00370037
52RNA degradation_Homo sapiens_hsa030180.92552609
53Collecting duct acid secretion_Homo sapiens_hsa049660.91275946
54Basal transcription factors_Homo sapiens_hsa030220.88191141
55Dorso-ventral axis formation_Homo sapiens_hsa043200.87236393
56Renin secretion_Homo sapiens_hsa049240.86130559
57Calcium signaling pathway_Homo sapiens_hsa040200.85876066
58T cell receptor signaling pathway_Homo sapiens_hsa046600.85146429
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.83365055
60Regulation of autophagy_Homo sapiens_hsa041400.83016888
61Arachidonic acid metabolism_Homo sapiens_hsa005900.82575646
62ABC transporters_Homo sapiens_hsa020100.80669225
63Fanconi anemia pathway_Homo sapiens_hsa034600.76376240
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75364651
65Platelet activation_Homo sapiens_hsa046110.74728844
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74110810
67Homologous recombination_Homo sapiens_hsa034400.74107364
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72932695
69Measles_Homo sapiens_hsa051620.67816265
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.67742614
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.67590294
72Nitrogen metabolism_Homo sapiens_hsa009100.64438679
73Salivary secretion_Homo sapiens_hsa049700.62042161
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61947660
75Type I diabetes mellitus_Homo sapiens_hsa049400.61721565
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60610345
77Axon guidance_Homo sapiens_hsa043600.60216365
78Cocaine addiction_Homo sapiens_hsa050300.58715133
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57163982
80Synaptic vesicle cycle_Homo sapiens_hsa047210.56342143
81Mineral absorption_Homo sapiens_hsa049780.56053205
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.55993758
83Basal cell carcinoma_Homo sapiens_hsa052170.55278661
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54256262
85Long-term depression_Homo sapiens_hsa047300.53815515
86Osteoclast differentiation_Homo sapiens_hsa043800.53614064
87Hedgehog signaling pathway_Homo sapiens_hsa043400.52285044
88Ovarian steroidogenesis_Homo sapiens_hsa049130.52172594
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51902582
90Toxoplasmosis_Homo sapiens_hsa051450.51103610
91B cell receptor signaling pathway_Homo sapiens_hsa046620.49101811
92beta-Alanine metabolism_Homo sapiens_hsa004100.46856904
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46834856
94Other glycan degradation_Homo sapiens_hsa005110.46022185
95* Metabolic pathways_Homo sapiens_hsa011000.45477575
96Propanoate metabolism_Homo sapiens_hsa006400.44910431
97Acute myeloid leukemia_Homo sapiens_hsa052210.44713899
98Type II diabetes mellitus_Homo sapiens_hsa049300.43950156
99Sulfur metabolism_Homo sapiens_hsa009200.42896470
100Chronic myeloid leukemia_Homo sapiens_hsa052200.42752083
101Pancreatic secretion_Homo sapiens_hsa049720.42569531
102Amphetamine addiction_Homo sapiens_hsa050310.40050172
103Oxytocin signaling pathway_Homo sapiens_hsa049210.39267959
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.39229416
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39019250
106Apoptosis_Homo sapiens_hsa042100.38966463
107Melanoma_Homo sapiens_hsa052180.38651459
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37892742
109Protein export_Homo sapiens_hsa030600.35568942
110Leishmaniasis_Homo sapiens_hsa051400.35259830
111Prolactin signaling pathway_Homo sapiens_hsa049170.34508375
112TNF signaling pathway_Homo sapiens_hsa046680.34106118
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.33873474
114* Serotonergic synapse_Homo sapiens_hsa047260.32858172
115Non-small cell lung cancer_Homo sapiens_hsa052230.32792975
116Vibrio cholerae infection_Homo sapiens_hsa051100.31859953
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31563437
118Dilated cardiomyopathy_Homo sapiens_hsa054140.30889889
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30763801
120Primary immunodeficiency_Homo sapiens_hsa053400.27860297
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27100371
122Protein digestion and absorption_Homo sapiens_hsa049740.26542871
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25420670
124Insulin secretion_Homo sapiens_hsa049110.25313535
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24954468
126ECM-receptor interaction_Homo sapiens_hsa045120.24882839
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24672311
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24556664
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24530474
130Hepatitis B_Homo sapiens_hsa051610.23767099
131Chemokine signaling pathway_Homo sapiens_hsa040620.23236323
132Renal cell carcinoma_Homo sapiens_hsa052110.22075480
133Pancreatic cancer_Homo sapiens_hsa052120.21882130
134Rap1 signaling pathway_Homo sapiens_hsa040150.21587734
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.21364383
136Estrogen signaling pathway_Homo sapiens_hsa049150.19170010
137Viral carcinogenesis_Homo sapiens_hsa052030.17798417
138Influenza A_Homo sapiens_hsa051640.17335349
139Long-term potentiation_Homo sapiens_hsa047200.17150831
140p53 signaling pathway_Homo sapiens_hsa041150.16488118
141Glioma_Homo sapiens_hsa052140.16424502
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15550659
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15266655
144Small cell lung cancer_Homo sapiens_hsa052220.13148451
145MAPK signaling pathway_Homo sapiens_hsa040100.13031531
146Cholinergic synapse_Homo sapiens_hsa047250.12838489
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12129190
148Prion diseases_Homo sapiens_hsa050200.11899540
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11751103
150Dopaminergic synapse_Homo sapiens_hsa047280.11683691
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.11599854
152Colorectal cancer_Homo sapiens_hsa052100.11201463
153FoxO signaling pathway_Homo sapiens_hsa040680.10830329
154Shigellosis_Homo sapiens_hsa051310.10289446
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.09834769
156Insulin resistance_Homo sapiens_hsa049310.09646011
157Amoebiasis_Homo sapiens_hsa051460.08692224
158Inositol phosphate metabolism_Homo sapiens_hsa005620.08249825
159Thyroid hormone synthesis_Homo sapiens_hsa049180.08149862
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08087236
161VEGF signaling pathway_Homo sapiens_hsa043700.07906290
162Focal adhesion_Homo sapiens_hsa045100.07873910
163Morphine addiction_Homo sapiens_hsa050320.07263507
164PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06766354
165cAMP signaling pathway_Homo sapiens_hsa040240.06246565
166NF-kappa B signaling pathway_Homo sapiens_hsa040640.05795720
167Gastric acid secretion_Homo sapiens_hsa049710.05562828
168Histidine metabolism_Homo sapiens_hsa003400.05459938
169Proteoglycans in cancer_Homo sapiens_hsa052050.05362039
170Bladder cancer_Homo sapiens_hsa052190.04976884
171Endocytosis_Homo sapiens_hsa041440.04784565
172Glucagon signaling pathway_Homo sapiens_hsa049220.04707826
173Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04690245
174HIF-1 signaling pathway_Homo sapiens_hsa040660.04625509
175MicroRNAs in cancer_Homo sapiens_hsa052060.04546485

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