TPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuromuscular process controlling posture (GO:0050884)9.17175540
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.43706005
3neurotransmitter uptake (GO:0001504)7.37188588
4synaptic vesicle maturation (GO:0016188)6.76870346
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42063264
6neurotransmitter catabolic process (GO:0042135)6.39157284
7synaptic vesicle exocytosis (GO:0016079)6.20843704
8* serotonin metabolic process (GO:0042428)6.18098154
9regulation of catecholamine metabolic process (GO:0042069)6.00010799
10regulation of dopamine metabolic process (GO:0042053)6.00010799
11righting reflex (GO:0060013)5.91508359
12regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.86946671
13startle response (GO:0001964)5.69028829
14proline transport (GO:0015824)5.65606320
15monoamine transport (GO:0015844)5.58054400
16phenol-containing compound catabolic process (GO:0019336)5.50685287
17regulation of synaptic transmission, dopaminergic (GO:0032225)5.46396633
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.30806515
19thalamus development (GO:0021794)5.27989475
20neurotransmitter secretion (GO:0007269)5.24894515
21tryptophan catabolic process (GO:0006569)5.24142801
22indole-containing compound catabolic process (GO:0042436)5.24142801
23indolalkylamine catabolic process (GO:0046218)5.24142801
24* primary amino compound metabolic process (GO:1901160)5.17307101
25brain morphogenesis (GO:0048854)5.16972471
26regulation of neurotransmitter levels (GO:0001505)5.10947544
27cerebellar Purkinje cell differentiation (GO:0021702)4.98988953
28vocalization behavior (GO:0071625)4.97945328
29neurotransmitter transport (GO:0006836)4.96413886
30kynurenine metabolic process (GO:0070189)4.83214856
31dopamine transport (GO:0015872)4.77967941
32exploration behavior (GO:0035640)4.75859424
33glutamate secretion (GO:0014047)4.75558263
34regulation of respiratory system process (GO:0044065)4.74121653
35regulation of transmission of nerve impulse (GO:0051969)4.68523014
36regulation of synaptic vesicle exocytosis (GO:2000300)4.58003912
37negative regulation of neural precursor cell proliferation (GO:2000178)4.53335255
38tryptophan metabolic process (GO:0006568)4.52601541
39catecholamine transport (GO:0051937)4.43994871
40regulation of synapse structural plasticity (GO:0051823)4.43639602
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.39182383
42neuron maturation (GO:0042551)4.37100775
43detection of light stimulus involved in visual perception (GO:0050908)4.32273630
44detection of light stimulus involved in sensory perception (GO:0050962)4.32273630
45regulation of synaptic vesicle transport (GO:1902803)4.28965216
46neurotransmitter metabolic process (GO:0042133)4.27679609
47negative regulation of neurotransmitter transport (GO:0051589)4.26273859
48regulation of glutamate receptor signaling pathway (GO:1900449)4.13615631
49neuron cell-cell adhesion (GO:0007158)4.08233578
50cilium or flagellum-dependent cell motility (GO:0001539)4.04732228
51signal peptide processing (GO:0006465)4.04670552
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03034348
53* indolalkylamine metabolic process (GO:0006586)3.99000593
54locomotory exploration behavior (GO:0035641)3.98495366
55intraspecies interaction between organisms (GO:0051703)3.97158334
56social behavior (GO:0035176)3.97158334
57response to histamine (GO:0034776)3.96858239
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96507497
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.92414484
60behavioral response to cocaine (GO:0048148)3.90658028
61regulation of vesicle fusion (GO:0031338)3.89517370
62alkaloid metabolic process (GO:0009820)3.85508536
63cerebellar Purkinje cell layer development (GO:0021680)3.85367515
64regulation of respiratory gaseous exchange (GO:0043576)3.83423214
65photoreceptor cell maintenance (GO:0045494)3.82507860
66tachykinin receptor signaling pathway (GO:0007217)3.81488355
67vasoconstriction (GO:0042310)3.79456360
68monoubiquitinated protein deubiquitination (GO:0035520)3.72846658
69behavioral response to nicotine (GO:0035095)3.68419493
70regulation of neuronal synaptic plasticity (GO:0048168)3.67863326
71negative regulation of glycogen metabolic process (GO:0070874)3.63753060
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61462724
73positive regulation of vesicle fusion (GO:0031340)3.60555921
74synaptic vesicle endocytosis (GO:0048488)3.59618308
75neural tube formation (GO:0001841)3.59006746
76positive regulation of developmental pigmentation (GO:0048087)3.58417835
77synaptic vesicle transport (GO:0048489)3.57609730
78establishment of synaptic vesicle localization (GO:0097480)3.57609730
79cellular biogenic amine catabolic process (GO:0042402)3.55454290
80amine catabolic process (GO:0009310)3.55454290
81DNA methylation involved in gamete generation (GO:0043046)3.52806014
82piRNA metabolic process (GO:0034587)3.50990171
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50433749
84cellular response to ammonium ion (GO:0071242)3.50166359
85cell communication by electrical coupling (GO:0010644)3.49893539
86activation of protein kinase A activity (GO:0034199)3.44806059
87serotonin receptor signaling pathway (GO:0007210)3.44385965
88reflex (GO:0060004)3.43934943
89dopamine biosynthetic process (GO:0042416)3.43004739
90retinal cone cell development (GO:0046549)3.42890731
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41733822
92cellular potassium ion homeostasis (GO:0030007)3.40116587
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39776129
94membrane hyperpolarization (GO:0060081)3.37134868
95calcium ion-dependent exocytosis (GO:0017156)3.36755440
96regulation of hippo signaling (GO:0035330)3.34581326
97establishment of protein localization to Golgi (GO:0072600)3.34379372
98neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.34180880
99protein localization to synapse (GO:0035418)3.33215272
100adult walking behavior (GO:0007628)3.32236861
101regulation of calcium ion-dependent exocytosis (GO:0017158)3.30406122
102oxygen transport (GO:0015671)3.29679484
103alanine transport (GO:0032328)3.28217025
104regulation of pigment cell differentiation (GO:0050932)3.27550038
105layer formation in cerebral cortex (GO:0021819)3.27367606
106positive regulation of cellular amine metabolic process (GO:0033240)3.27223435
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26712233
108regulation of Rac protein signal transduction (GO:0035020)3.25512054
109dopamine metabolic process (GO:0042417)3.24607786
110response to parathyroid hormone (GO:0071107)3.24382097
111regulation of gene silencing by RNA (GO:0060966)3.23276776
112regulation of posttranscriptional gene silencing (GO:0060147)3.23276776
113regulation of gene silencing by miRNA (GO:0060964)3.23276776
114neuromuscular process (GO:0050905)3.22297685
115L-fucose metabolic process (GO:0042354)3.22156054
116L-fucose catabolic process (GO:0042355)3.22156054
117fucose catabolic process (GO:0019317)3.22156054
118acrosome reaction (GO:0007340)3.21362504
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21265508
120protein K11-linked deubiquitination (GO:0035871)3.20900511
121postsynaptic membrane organization (GO:0001941)3.20233210
122dendritic spine morphogenesis (GO:0060997)3.19754407
123* indole-containing compound metabolic process (GO:0042430)3.17418548
124auditory receptor cell stereocilium organization (GO:0060088)3.17286685
125gamma-aminobutyric acid transport (GO:0015812)3.16984426
126positive regulation of potassium ion transmembrane transport (GO:1901381)3.16812114
127regulation of sarcomere organization (GO:0060297)3.15737881
128benzene-containing compound metabolic process (GO:0042537)3.13489741
129behavioral response to ethanol (GO:0048149)3.13366483
130regulation of NFAT protein import into nucleus (GO:0051532)3.12411490
131sodium ion export (GO:0071436)3.09818636
132cochlea development (GO:0090102)3.09321294
133snRNA transcription (GO:0009301)3.08446259
134NAD biosynthetic process (GO:0009435)3.07015621
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06962021
136transmission of nerve impulse (GO:0019226)3.05752510
137aromatic amino acid family catabolic process (GO:0009074)3.05672552
138cellular ketone body metabolic process (GO:0046950)3.01484183
139positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01160059
140cell migration in hindbrain (GO:0021535)3.01153263
141regulation of acrosome reaction (GO:0060046)3.00031486
142negative regulation of microtubule polymerization (GO:0031115)2.98540700
143response to pheromone (GO:0019236)2.97576144
144response to cocaine (GO:0042220)2.95755273
145signal release (GO:0023061)2.95413134
146multicellular organism reproduction (GO:0032504)2.93026303
147prenylation (GO:0097354)2.92171441
148protein prenylation (GO:0018342)2.92171441
149neuromuscular synaptic transmission (GO:0007274)2.91199338
150negative regulation of calcium ion transport into cytosol (GO:0010523)2.90756239
151negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87335760
152neuronal action potential (GO:0019228)2.87192516
153epithelial cilium movement (GO:0003351)2.86502112
154sphingoid metabolic process (GO:0046519)2.86143466
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.85975196
156regulation of translation, ncRNA-mediated (GO:0045974)2.85975196
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85975196
158protein K63-linked deubiquitination (GO:0070536)2.85424807
159methionine biosynthetic process (GO:0009086)2.84166227
160detection of mechanical stimulus involved in sensory perception (GO:0050974)2.83925665
161protein K48-linked deubiquitination (GO:0071108)2.83461327
162ketone body metabolic process (GO:1902224)2.78684936
163cilium movement (GO:0003341)2.76075424
164sulfation (GO:0051923)2.75961296
165regulation of meiosis I (GO:0060631)2.74533265
166cAMP catabolic process (GO:0006198)2.73620434
167negative regulation of mast cell activation (GO:0033004)2.73081393
168axoneme assembly (GO:0035082)2.70918031
169thyroid hormone metabolic process (GO:0042403)2.69066338
170reciprocal DNA recombination (GO:0035825)2.68779012
171reciprocal meiotic recombination (GO:0007131)2.68779012
172oxidative demethylation (GO:0070989)2.65503223
173amino acid salvage (GO:0043102)2.62024369
174L-methionine salvage (GO:0071267)2.62024369
175L-methionine biosynthetic process (GO:0071265)2.62024369
176cyclic nucleotide catabolic process (GO:0009214)2.60925843
177cellular response to sterol (GO:0036315)2.60917184
178regulation of establishment of cell polarity (GO:2000114)2.60530882
179interkinetic nuclear migration (GO:0022027)2.60366956
180DNA deamination (GO:0045006)2.58054437
181cilium organization (GO:0044782)2.55606672
182microtubule anchoring (GO:0034453)2.55604899
183negative regulation of systemic arterial blood pressure (GO:0003085)2.54265343
184regulation of collateral sprouting (GO:0048670)2.53813835
185inner ear receptor stereocilium organization (GO:0060122)2.53310189
186photoreceptor cell development (GO:0042461)2.52625339
187recombinational repair (GO:0000725)2.51817191
188double-strand break repair via homologous recombination (GO:0000724)2.51731161
189flavonoid metabolic process (GO:0009812)2.50393708
190cilium assembly (GO:0042384)2.50090283
191cilium morphogenesis (GO:0060271)2.47089894
192nonmotile primary cilium assembly (GO:0035058)2.46969796
193protein polyglutamylation (GO:0018095)2.44301550
194adaptation of signaling pathway (GO:0023058)2.43828742
195rhodopsin mediated signaling pathway (GO:0016056)2.43390381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58874279
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.19755571
3GBX2_23144817_ChIP-Seq_PC3_Human3.72959960
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12225977
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01610329
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89937123
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83950227
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65454397
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65454397
10REST_21632747_ChIP-Seq_MESCs_Mouse2.59661613
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48317601
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47739054
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46599714
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39233985
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38967321
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38536007
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35899741
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33415105
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27843293
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.26672808
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.25855503
22DROSHA_22980978_ChIP-Seq_HELA_Human2.19847992
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18774336
24ZNF274_21170338_ChIP-Seq_K562_Hela2.12691782
25AR_21572438_ChIP-Seq_LNCaP_Human2.07812031
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.07223906
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02801482
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.95633532
29FUS_26573619_Chip-Seq_HEK293_Human1.93532244
30EWS_26573619_Chip-Seq_HEK293_Human1.87927133
31SMAD4_21799915_ChIP-Seq_A2780_Human1.85196784
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81506128
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80465716
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.79989394
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.79780769
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78870513
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77028632
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74729545
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74186525
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.74177995
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.72312601
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70081047
43BCAT_22108803_ChIP-Seq_LS180_Human1.67352944
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.65753078
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63599655
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63599655
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63220310
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61051852
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59418085
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59312174
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58007222
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57834581
53* P300_19829295_ChIP-Seq_ESCs_Human1.57037758
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.56236635
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51389669
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50294148
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45573446
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44805134
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43999738
60TAF15_26573619_Chip-Seq_HEK293_Human1.43584210
61TCF4_22108803_ChIP-Seq_LS180_Human1.43417650
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42423709
63IGF1R_20145208_ChIP-Seq_DFB_Human1.42310072
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.38634101
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38434335
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.38161637
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.37879509
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36897822
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34233559
70SOX2_19829295_ChIP-Seq_ESCs_Human1.33347819
71NANOG_19829295_ChIP-Seq_ESCs_Human1.33347819
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.32397745
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.30258171
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30208138
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30084987
76AR_25329375_ChIP-Seq_VCAP_Human1.29320251
77* STAT3_23295773_ChIP-Seq_U87_Human1.29279142
78* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29062347
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28349342
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.27618238
81* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27309337
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25721815
83TP53_16413492_ChIP-PET_HCT116_Human1.25377421
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25217477
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24831895
86TP53_22573176_ChIP-Seq_HFKS_Human1.24671939
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24456116
88CDX2_22108803_ChIP-Seq_LS180_Human1.21326619
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19815095
90IRF1_19129219_ChIP-ChIP_H3396_Human1.19694592
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19660744
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.19426406
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18905941
94* AR_19668381_ChIP-Seq_PC3_Human1.17932140
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17546820
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17177762
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17170258
98* RNF2_27304074_Chip-Seq_NSC_Mouse1.16561887
99RXR_22108803_ChIP-Seq_LS180_Human1.16503703
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16430721
101* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16407774
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15234404
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.14965581
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14753811
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14629657
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14475846
107EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12592792
108VDR_22108803_ChIP-Seq_LS180_Human1.12376381
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.11870871
110* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11721252
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10907060
112ER_23166858_ChIP-Seq_MCF-7_Human1.09861650
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07973743
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07742867
115P53_22387025_ChIP-Seq_ESCs_Mouse1.06746532
116* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06290456
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.05913763
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.05348035
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05348035
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.05270375
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04987863
122KDM2B_26808549_Chip-Seq_REH_Human1.02955415
123* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02151940
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01854119
125TCF4_23295773_ChIP-Seq_U87_Human1.01725402
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01498162
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.00965780
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.00480508
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00056973
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.99912874
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99821847
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99766582
133TP53_18474530_ChIP-ChIP_U2OS_Human0.99309970
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99254691
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99075892
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98519868
137* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97986315
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97738947
139AHR_22903824_ChIP-Seq_MCF-7_Human0.97059718
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96736052
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.96188547
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96031886
143CBP_20019798_ChIP-Seq_JUKART_Human0.96031289
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96031289
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.96007259
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.94125798
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93702910
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92612501
149RUNX2_22187159_ChIP-Seq_PCA_Human0.92073987
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90413106
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89833820
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89245960
153JUN_21703547_ChIP-Seq_K562_Human0.89116389
154* FLI1_21867929_ChIP-Seq_TH2_Mouse0.88832386
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.88620974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.12546892
2MP0005645_abnormal_hypothalamus_physiol4.25048339
3MP0009046_muscle_twitch4.12377759
4MP0003123_paternal_imprinting4.09455292
5MP0003195_calcinosis3.88473371
6MP0004859_abnormal_synaptic_plasticity3.83817251
7* MP0006276_abnormal_autonomic_nervous3.66326406
8* MP0001501_abnormal_sleep_pattern3.33183565
9MP0003635_abnormal_synaptic_transmissio3.28245928
10MP0003787_abnormal_imprinting3.13732341
11MP0008057_abnormal_DNA_replication2.91082213
12MP0002272_abnormal_nervous_system2.88681869
13* MP0002572_abnormal_emotion/affect_behav2.83773049
14MP0002064_seizures2.80587736
15MP0005646_abnormal_pituitary_gland2.76541732
16MP0000569_abnormal_digit_pigmentation2.68633468
17MP0009745_abnormal_behavioral_response2.64282483
18MP0005423_abnormal_somatic_nervous2.61223537
19MP0002909_abnormal_adrenal_gland2.51487942
20MP0002733_abnormal_thermal_nociception2.46340946
21MP0002063_abnormal_learning/memory/cond2.43612709
22MP0003121_genomic_imprinting2.36852925
23MP0003136_yellow_coat_color2.36068816
24MP0004270_analgesia2.34601687
25MP0004142_abnormal_muscle_tone2.26673042
26MP0002102_abnormal_ear_morphology2.22284496
27MP0003880_abnormal_central_pattern2.21397121
28MP0001905_abnormal_dopamine_level2.19732730
29MP0004147_increased_porphyrin_level2.15696132
30MP0001486_abnormal_startle_reflex2.13398219
31MP0002138_abnormal_hepatobiliary_system2.02338751
32MP0004924_abnormal_behavior1.97923659
33MP0005386_behavior/neurological_phenoty1.97923659
34MP0000372_irregular_coat_pigmentation1.91557774
35MP0008877_abnormal_DNA_methylation1.87011431
36MP0002734_abnormal_mechanical_nocicepti1.80175328
37MP0003950_abnormal_plasma_membrane1.75248386
38MP0000427_abnormal_hair_cycle1.74341422
39MP0005253_abnormal_eye_physiology1.73458388
40MP0008775_abnormal_heart_ventricle1.72907598
41MP0004043_abnormal_pH_regulation1.72162853
42* MP0002557_abnormal_social/conspecific_i1.70855071
43MP0008872_abnormal_physiological_respon1.70015753
44MP0005174_abnormal_tail_pigmentation1.69065342
45MP0001188_hyperpigmentation1.68152269
46MP0002184_abnormal_innervation1.66172559
47* MP0005535_abnormal_body_temperature1.65567193
48MP0006054_spinal_hemorrhage1.64622102
49MP0003045_fibrosis1.64044216
50MP0005085_abnormal_gallbladder_physiolo1.56634384
51MP0003718_maternal_effect1.52531815
52MP0001968_abnormal_touch/_nociception1.50807770
53MP0002067_abnormal_sensory_capabilities1.40951910
54MP0000383_abnormal_hair_follicle1.40700679
55MP0002876_abnormal_thyroid_physiology1.40631867
56MP0003329_amyloid_beta_deposits1.40358610
57MP0005171_absent_coat_pigmentation1.36866827
58MP0003252_abnormal_bile_duct1.35389291
59MP0005167_abnormal_blood-brain_barrier1.28825718
60MP0001984_abnormal_olfaction1.27771469
61MP0006072_abnormal_retinal_apoptosis1.27681655
62MP0001440_abnormal_grooming_behavior1.26953656
63MP0001970_abnormal_pain_threshold1.26800228
64MP0005330_cardiomyopathy1.25073333
65MP0001485_abnormal_pinna_reflex1.24846689
66MP0001986_abnormal_taste_sensitivity1.24104344
67* MP0002066_abnormal_motor_capabilities/c1.23483620
68MP0003879_abnormal_hair_cell1.22893926
69MP0010386_abnormal_urinary_bladder1.22833443
70MP0005670_abnormal_white_adipose1.22741931
71MP0008875_abnormal_xenobiotic_pharmacok1.20990217
72MP0004811_abnormal_neuron_physiology1.20958234
73MP0004885_abnormal_endolymph1.19687738
74MP0005075_abnormal_melanosome_morpholog1.19090355
75MP0004145_abnormal_muscle_electrophysio1.18743312
76MP0006292_abnormal_olfactory_placode1.16141834
77* MP0002882_abnormal_neuron_morphology1.16110570
78MP0009780_abnormal_chondrocyte_physiolo1.15011495
79MP0000015_abnormal_ear_pigmentation1.14855746
80MP0002938_white_spotting1.14324128
81MP0005647_abnormal_sex_gland1.13006272
82MP0003890_abnormal_embryonic-extraembry1.11169686
83MP0005310_abnormal_salivary_gland1.10140053
84MP0002928_abnormal_bile_duct1.09906558
85MP0003172_abnormal_lysosome_physiology1.09805433
86MP0003698_abnormal_male_reproductive1.09052394
87MP0005395_other_phenotype1.08696095
88MP0002168_other_aberrant_phenotype1.07519986
89MP0008874_decreased_physiological_sensi1.06230218
90MP0000751_myopathy1.05261670
91MP0005409_darkened_coat_color1.03339738
92MP0004233_abnormal_muscle_weight1.03116118
93MP0002095_abnormal_skin_pigmentation1.02994498
94MP0008569_lethality_at_weaning1.02980294
95MP0002837_dystrophic_cardiac_calcinosis1.02240246
96MP0003878_abnormal_ear_physiology1.01634767
97MP0005377_hearing/vestibular/ear_phenot1.01634767
98MP0002653_abnormal_ependyma_morphology1.01589267
99MP0005503_abnormal_tendon_morphology0.98739382
100MP0001929_abnormal_gametogenesis0.97137754
101MP0002877_abnormal_melanocyte_morpholog0.95709648
102MP0001348_abnormal_lacrimal_gland0.94068863
103MP0004381_abnormal_hair_follicle0.93737496
104MP0004742_abnormal_vestibular_system0.93630043
105MP0000579_abnormal_nail_morphology0.93170817
106MP0008058_abnormal_DNA_repair0.90739385
107MP0003632_abnormal_nervous_system0.89889501
108* MP0000230_abnormal_systemic_arterial0.89658421
109MP0001299_abnormal_eye_distance/0.88739261
110MP0005389_reproductive_system_phenotype0.88624442
111MP0005266_abnormal_metabolism0.88346739
112MP0003690_abnormal_glial_cell0.87376942
113MP0000778_abnormal_nervous_system0.87239294
114MP0001529_abnormal_vocalization0.86904461
115MP0001502_abnormal_circadian_rhythm0.86552033
116MP0002736_abnormal_nociception_after0.83958301
117MP0001324_abnormal_eye_pigmentation0.83933153
118MP0000371_diluted_coat_color0.82522849
119MP0000955_abnormal_spinal_cord0.81394269
120MP0001764_abnormal_homeostasis0.80626936
121MP0009697_abnormal_copulation0.79932819
122MP0002229_neurodegeneration0.79198532
123MP0002693_abnormal_pancreas_physiology0.78268502
124MP0002210_abnormal_sex_determination0.77510819
125MP0001664_abnormal_digestion0.77391367
126* MP0003953_abnormal_hormone_level0.77314126
127MP0002152_abnormal_brain_morphology0.75800117
128MP0002160_abnormal_reproductive_system0.75575761
129MP0005195_abnormal_posterior_eye0.75142929
130MP0003137_abnormal_impulse_conducting0.74275162
131MP0003631_nervous_system_phenotype0.74028015
132MP0002638_abnormal_pupillary_reflex0.69688825
133MP0003633_abnormal_nervous_system0.69598013
134MP0004215_abnormal_myocardial_fiber0.67833600
135MP0010769_abnormal_survival0.66204703
136MP0010770_preweaning_lethality0.65056418
137MP0002082_postnatal_lethality0.65056418
138MP0000631_abnormal_neuroendocrine_gland0.64683891
139MP0005076_abnormal_cell_differentiation0.64052728
140MP0000639_abnormal_adrenal_gland0.63501765
141MP0002972_abnormal_cardiac_muscle0.63491878
142MP0004858_abnormal_nervous_system0.61765671
143MP0010768_mortality/aging0.61392733
144MP0000747_muscle_weakness0.61354321
145* MP0004085_abnormal_heartbeat0.59252778
146MP0003634_abnormal_glial_cell0.58910474
147MP0003646_muscle_fatigue0.58378965
148MP0000538_abnormal_urinary_bladder0.57686601
149MP0004883_abnormal_blood_vessel0.57406440
150MP0000604_amyloidosis0.56841656
151MP0005410_abnormal_fertilization0.56242024
152MP0002735_abnormal_chemical_nociception0.54950317
153MP0005620_abnormal_muscle_contractility0.53531566
154MP0003075_altered_response_to0.53253212
155MP0004130_abnormal_muscle_cell0.53004406
156* MP0001943_abnormal_respiration0.52350267
157MP0005551_abnormal_eye_electrophysiolog0.52185277
158MP0005084_abnormal_gallbladder_morpholo0.51442944
159MP0002108_abnormal_muscle_morphology0.51437610
160MP0005623_abnormal_meninges_morphology0.49547583

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.88453384
2Focal seizures (HP:0007359)4.97500958
3Myokymia (HP:0002411)4.74428081
4Pancreatic cysts (HP:0001737)4.68666824
5Hyperthyroidism (HP:0000836)4.66378889
6Frequent falls (HP:0002359)4.62285220
7Visual hallucinations (HP:0002367)4.59214843
8Progressive cerebellar ataxia (HP:0002073)4.37463041
9Limb dystonia (HP:0002451)4.32929132
10Hypokinesia (HP:0002375)4.28928240
11Limb hypertonia (HP:0002509)4.24623698
12Focal motor seizures (HP:0011153)4.17293143
13Action tremor (HP:0002345)4.15424759
14Postural instability (HP:0002172)4.09550820
15Pancreatic fibrosis (HP:0100732)4.07487677
16Agitation (HP:0000713)4.06308805
17Absence seizures (HP:0002121)3.93936101
18True hermaphroditism (HP:0010459)3.87163276
19Generalized tonic-clonic seizures (HP:0002069)3.86621629
20Attenuation of retinal blood vessels (HP:0007843)3.79418624
21Papilledema (HP:0001085)3.66955968
22Abnormality of midbrain morphology (HP:0002418)3.62840153
23Molar tooth sign on MRI (HP:0002419)3.62840153
24Congenital stationary night blindness (HP:0007642)3.59123933
25Pheochromocytoma (HP:0002666)3.58520927
26Atonic seizures (HP:0010819)3.57070127
27Ankle clonus (HP:0011448)3.56609657
28Supranuclear gaze palsy (HP:0000605)3.55172852
29Diminished movement (HP:0002374)3.48015681
30Spontaneous abortion (HP:0005268)3.46433939
31Genetic anticipation (HP:0003743)3.43498364
32Anxiety (HP:0000739)3.39646466
33Urinary bladder sphincter dysfunction (HP:0002839)3.36527575
34Abnormal pupillary function (HP:0007686)3.34870373
35Dialeptic seizures (HP:0011146)3.33069435
36Abnormality of the renal cortex (HP:0011035)3.28975160
37Torticollis (HP:0000473)3.18468315
38Choreoathetosis (HP:0001266)3.16062933
39Postural tremor (HP:0002174)3.11030512
40Epileptic encephalopathy (HP:0200134)3.08900656
41Mutism (HP:0002300)3.07261375
42Nephronophthisis (HP:0000090)3.06065600
43Neuroendocrine neoplasm (HP:0100634)3.02347998
44Abnormality of the corticospinal tract (HP:0002492)2.98203928
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.96034745
46Bony spicule pigmentary retinopathy (HP:0007737)2.95646443
47Cystic liver disease (HP:0006706)2.95378355
48Abnormality of the renal medulla (HP:0100957)2.90723361
49Truncal ataxia (HP:0002078)2.88830175
50Chronic hepatic failure (HP:0100626)2.88421314
51Abolished electroretinogram (ERG) (HP:0000550)2.87237509
52Drooling (HP:0002307)2.86075422
53Excessive salivation (HP:0003781)2.86075422
54Menstrual irregularities (HP:0000858)2.85014927
55Febrile seizures (HP:0002373)2.84040460
56Protruding tongue (HP:0010808)2.79398955
57Type II lissencephaly (HP:0007260)2.78596060
58Medial flaring of the eyebrow (HP:0010747)2.78198411
59Clumsiness (HP:0002312)2.73414432
60Macroorchidism (HP:0000053)2.72439852
61Congenital sensorineural hearing impairment (HP:0008527)2.68500564
62Hypercortisolism (HP:0001578)2.68126839
63Broad-based gait (HP:0002136)2.67210612
64Fetal akinesia sequence (HP:0001989)2.66756113
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62829662
66Akinesia (HP:0002304)2.62731872
67Status epilepticus (HP:0002133)2.62218541
68Urinary urgency (HP:0000012)2.59282287
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58986717
70Bowel incontinence (HP:0002607)2.57624207
71Craniofacial dystonia (HP:0012179)2.57134147
72Poor suck (HP:0002033)2.54684530
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54239474
74Depression (HP:0000716)2.53961389
75Central scotoma (HP:0000603)2.52089800
76Decreased central vision (HP:0007663)2.51694823
77Abnormal rod and cone electroretinograms (HP:0008323)2.49115980
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.47185272
79Fair hair (HP:0002286)2.46842426
80Spastic gait (HP:0002064)2.46178437
81Psychosis (HP:0000709)2.46032929
82Inability to walk (HP:0002540)2.45410250
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44913770
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.44717064
85Absent/shortened dynein arms (HP:0200106)2.44717064
86Focal dystonia (HP:0004373)2.43013006
87Aqueductal stenosis (HP:0002410)2.40032316
88Stomach cancer (HP:0012126)2.39067602
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38403725
90Abnormality of alanine metabolism (HP:0010916)2.38403725
91Hyperalaninemia (HP:0003348)2.38403725
92Increased corneal curvature (HP:0100692)2.37864986
93Keratoconus (HP:0000563)2.37864986
94Abnormal large intestine physiology (HP:0012700)2.36944995
95Progressive inability to walk (HP:0002505)2.36713074
96Impaired social interactions (HP:0000735)2.31558731
97Abnormal social behavior (HP:0012433)2.31558731
98Abnormal drinking behavior (HP:0030082)2.31448517
99Polydipsia (HP:0001959)2.31448517
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.31060416
101Gait imbalance (HP:0002141)2.30689766
102Lower limb muscle weakness (HP:0007340)2.28798480
103Abnormal ciliary motility (HP:0012262)2.28094569
104Tubular atrophy (HP:0000092)2.27771721
105Truncus arteriosus (HP:0001660)2.26502884
106Congenital primary aphakia (HP:0007707)2.26400565
107Renal cortical cysts (HP:0000803)2.24911230
108Constricted visual fields (HP:0001133)2.21145551
109Congenital hepatic fibrosis (HP:0002612)2.20383438
110Dysmetric saccades (HP:0000641)2.20328483
111EEG with generalized epileptiform discharges (HP:0011198)2.18520011
112Hypsarrhythmia (HP:0002521)2.18442186
113Impaired smooth pursuit (HP:0007772)2.18280612
114Hemiplegia (HP:0002301)2.18256466
115Gaze-evoked nystagmus (HP:0000640)2.17628479
116Decreased circulating renin level (HP:0003351)2.17236437
117Bradykinesia (HP:0002067)2.16420556
118Poor eye contact (HP:0000817)2.16247464
119Anencephaly (HP:0002323)2.15879393
120Abnormality of macular pigmentation (HP:0008002)2.14441808
121Epileptiform EEG discharges (HP:0011182)2.14399559
122Dysmetria (HP:0001310)2.13915334
123Neoplasm of the peripheral nervous system (HP:0100007)2.13205701
124Sclerocornea (HP:0000647)2.13122104
125Cerebellar dysplasia (HP:0007033)2.12518003
126Abnormal biliary tract physiology (HP:0012439)2.12135388
127Bile duct proliferation (HP:0001408)2.12135388
128Absent speech (HP:0001344)2.11343940
129Furrowed tongue (HP:0000221)2.11305765
130Dysdiadochokinesis (HP:0002075)2.10346383
131Generalized myoclonic seizures (HP:0002123)2.10310299
132Impaired vibration sensation in the lower limbs (HP:0002166)2.09650026
133Aplasia of the musculature (HP:0100854)2.09480229
134Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08356627
135Genital tract atresia (HP:0001827)2.06914313
136Hyperventilation (HP:0002883)2.06857728
137Nephrogenic diabetes insipidus (HP:0009806)2.05190501
138Scotoma (HP:0000575)2.04939382
139Generalized hypopigmentation of hair (HP:0011358)2.04791287
140Clonus (HP:0002169)2.02513953
141Restlessness (HP:0000711)2.01955332
142Myoclonus (HP:0001336)1.99980929
143Severe visual impairment (HP:0001141)1.98913473
144Concave nail (HP:0001598)1.97699410
145Pendular nystagmus (HP:0012043)1.96984371
146Abnormality of salivation (HP:0100755)1.96559347
147Abnormal eating behavior (HP:0100738)1.96067613
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95746177
149Insidious onset (HP:0003587)1.95618899
150Termporal pattern (HP:0011008)1.95618899
151Heterochromia iridis (HP:0001100)1.94973287
152Failure to thrive in infancy (HP:0001531)1.94198387
153Vaginal atresia (HP:0000148)1.93917541
154Male pseudohermaphroditism (HP:0000037)1.93399778
155Atelectasis (HP:0100750)1.92080934
156Intestinal atresia (HP:0011100)1.90849404
157Enlarged kidneys (HP:0000105)1.90812249
158Lissencephaly (HP:0001339)1.90158758
159Patellar dislocation (HP:0002999)1.89061656
160Postaxial foot polydactyly (HP:0001830)1.88619180
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.88573755
162Polyphagia (HP:0002591)1.88564531
163Retinitis pigmentosa (HP:0000510)1.88454216
164Abnormality of pain sensation (HP:0010832)1.87921236
165Impaired pain sensation (HP:0007328)1.87921236
166Exotropia (HP:0000577)1.87369219
167Ventricular fibrillation (HP:0001663)1.86264582
168Large for gestational age (HP:0001520)1.85651968
169Rigidity (HP:0002063)1.85168257
170Abnormal respiratory motile cilium morphology (HP:0005938)1.84601999
171Abnormal respiratory epithelium morphology (HP:0012253)1.84601999
172Small hand (HP:0200055)1.82638004
173Polyuria (HP:0000103)1.81943040
174Ketosis (HP:0001946)1.80257120
175Widely spaced teeth (HP:0000687)1.79798543
176Poor coordination (HP:0002370)1.79121417
177Thyroid-stimulating hormone excess (HP:0002925)1.78521699
178Abnormal respiratory motile cilium physiology (HP:0012261)1.77866184
179Volvulus (HP:0002580)1.75517482
180Aplasia/Hypoplasia of the fovea (HP:0008060)1.74991165
181Hypoplasia of the fovea (HP:0007750)1.74991165
182Albinism (HP:0001022)1.67938287
183Astigmatism (HP:0000483)1.67906256
184Facial diplegia (HP:0001349)1.66964697
185Increased cerebral lipofuscin (HP:0011813)1.66937348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.87010964
2NTRK37.49353818
3ACVR1B4.29073492
4MAP3K43.71307889
5MAP3K93.68146572
6PAK63.28639952
7PNCK2.91461343
8BMPR1B2.82614528
9ADRBK22.54490294
10MAP3K122.53883965
11MAP2K72.51717148
12ZAK2.50384160
13WNK32.43654088
14MINK12.32935212
15CSNK1G22.32761651
16CSNK1G32.28072732
17MAP4K22.21116259
18MAP2K42.15973226
19TAOK32.13569782
20PAK32.04682489
21UHMK12.04428314
22CDK191.93918260
23NTRK21.89248078
24MARK11.87493924
25GRK11.84257788
26NEK11.78436660
27NUAK11.74327505
28PINK11.72733227
29STK38L1.72228251
30TAOK11.67570503
31LATS21.66193668
32CSNK1G11.62469622
33GRK51.61738801
34LATS11.55120713
35TXK1.49494774
36MKNK21.47328168
37TEC1.46678501
38PIK3CG1.44023304
39MST41.41784135
40CASK1.39260015
41ALK1.35199040
42STK381.33399212
43* CAMK2A1.27046330
44CAMK1G1.20716588
45MAPK131.18133259
46CDK51.14684652
47PRKCG1.09187351
48TRIM281.09018304
49DAPK21.08325430
50PLK21.06537017
51TLK11.03795661
52FES1.03392969
53PTK2B1.02825254
54AKT30.99880930
55TNIK0.91637189
56OXSR10.89495476
57SIK10.88660655
58ICK0.87134574
59PRKCE0.87133376
60CAMK10.86829491
61PHKG10.85859918
62PHKG20.85859918
63PRKCH0.85699836
64PRKG10.83588393
65STK30.83282043
66WNK10.81228698
67GRK70.80757634
68MARK30.78409093
69LMTK20.76174863
70FER0.75834703
71NTRK10.75156731
72BCR0.74474917
73CDK140.74126725
74SCYL20.71899735
75CAMKK10.71006328
76ITK0.70688575
77CSNK1A1L0.68625274
78STK110.68056211
79NLK0.67621750
80CDK150.66865877
81MAP3K130.66778139
82CDK180.66488667
83KSR20.66175136
84IRAK10.65585221
85MAPK90.65526033
86ADRBK10.64708139
87CAMK2G0.64300827
88DAPK10.62533085
89TGFBR10.62230190
90TNK20.59308409
91MKNK10.58992092
92OBSCN0.58017640
93CDC42BPA0.58005814
94CDK11A0.57851159
95EIF2AK30.57343028
96RPS6KA30.57032777
97CSNK1A10.56774612
98IKBKB0.56464170
99TIE10.56113947
100MUSK0.55579276
101PRKAA20.54812592
102PKN10.54294931
103BRSK20.54148683
104SGK10.53440588
105BMX0.51967186
106PDK10.51931631
107LIMK10.51743681
108EPHA40.50389809
109KSR10.49935676
110FLT30.49926748
111PRKCA0.49668614
112CSNK1D0.48875671
113PLK40.48060020
114MAPK100.47650940
115PIK3CA0.46772118
116MOS0.46367367
117RET0.46189876
118ERBB30.45106462
119KIT0.44935394
120SYK0.44682702
121MAP3K70.44182528
122PRKAA10.43234804
123PRKACG0.43080866
124SGK20.42013834
125RPS6KA20.40816479
126FYN0.40753265
127PRKCQ0.40575435
128STK390.40523143
129CAMKK20.40113181
130BRD40.39816617
131CSNK1E0.39629730
132PRKCZ0.38165246
133INSRR0.37662610
134* PRKACA0.37474962
135MELK0.37414172
136PDPK10.37405533
137SIK20.37113962
138SGK30.37069983
139CHUK0.36562776
140MAP2K10.36467693
141JAK10.36176192
142MAP3K60.35747770
143MARK20.35747440
144MAPK40.35706163
145RPS6KA50.34721131
146MAP3K20.34615131
147PRKACB0.34329880
148BTK0.33980356
149PRKD20.33075252
150MAP3K10.32394491
151WNK40.32260052
152MAPKAPK50.31297754
153PRKCB0.31103816
154CAMK40.30536741
155ROCK10.30204702
156ERBB20.29999131
157VRK10.29897208
158MAP2K60.29534857
159TRPM70.29365683
160MAPK80.29110250
161PIM10.28542663
162ATM0.28375627
163PAK20.27516207
164DYRK20.27515867
165ABL10.26886391
166CHEK20.26837092
167DYRK1A0.25385592

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.08818734
2* Serotonergic synapse_Homo sapiens_hsa047263.30071799
3Nicotine addiction_Homo sapiens_hsa050333.22687077
4Phototransduction_Homo sapiens_hsa047443.02756001
5Cocaine addiction_Homo sapiens_hsa050303.02445052
6GABAergic synapse_Homo sapiens_hsa047272.82079660
7Amphetamine addiction_Homo sapiens_hsa050312.70711415
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49157965
9Dopaminergic synapse_Homo sapiens_hsa047282.47056017
10Phenylalanine metabolism_Homo sapiens_hsa003602.46518187
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46258677
12ABC transporters_Homo sapiens_hsa020102.41693406
13Insulin secretion_Homo sapiens_hsa049112.26332414
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.20880857
15Homologous recombination_Homo sapiens_hsa034402.20813709
16Salivary secretion_Homo sapiens_hsa049702.14466927
17Linoleic acid metabolism_Homo sapiens_hsa005912.11806963
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10634574
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09355614
20Morphine addiction_Homo sapiens_hsa050322.08307978
21Taste transduction_Homo sapiens_hsa047422.05109025
22Primary bile acid biosynthesis_Homo sapiens_hsa001202.00064932
23Olfactory transduction_Homo sapiens_hsa047401.98719810
24Circadian entrainment_Homo sapiens_hsa047131.92559008
25Tyrosine metabolism_Homo sapiens_hsa003501.85706768
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82566975
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.81724847
28Glutamatergic synapse_Homo sapiens_hsa047241.74465931
29Propanoate metabolism_Homo sapiens_hsa006401.69963129
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66970275
31Fanconi anemia pathway_Homo sapiens_hsa034601.57647115
32Butanoate metabolism_Homo sapiens_hsa006501.54787981
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54683102
34Selenocompound metabolism_Homo sapiens_hsa004501.49039721
35Collecting duct acid secretion_Homo sapiens_hsa049661.48843749
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48520547
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48351715
38Ether lipid metabolism_Homo sapiens_hsa005651.47855574
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46777916
40Histidine metabolism_Homo sapiens_hsa003401.46522278
41Renin secretion_Homo sapiens_hsa049241.44828546
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44800819
43Long-term potentiation_Homo sapiens_hsa047201.43521660
44Chemical carcinogenesis_Homo sapiens_hsa052041.41986520
45Type II diabetes mellitus_Homo sapiens_hsa049301.41351440
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40867553
47Cholinergic synapse_Homo sapiens_hsa047251.38986691
48Basal transcription factors_Homo sapiens_hsa030221.35356631
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33355191
50Vibrio cholerae infection_Homo sapiens_hsa051101.31988958
51Gastric acid secretion_Homo sapiens_hsa049711.27991675
52Retinol metabolism_Homo sapiens_hsa008301.23278495
53Gap junction_Homo sapiens_hsa045401.22880995
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.21305303
55Long-term depression_Homo sapiens_hsa047301.19257676
56Cardiac muscle contraction_Homo sapiens_hsa042601.10271879
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09610301
58Oxytocin signaling pathway_Homo sapiens_hsa049211.08950389
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08803902
60Dorso-ventral axis formation_Homo sapiens_hsa043201.08143318
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06721479
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06606658
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04978764
64GnRH signaling pathway_Homo sapiens_hsa049121.01733503
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00795131
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98148048
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.97602186
68Non-homologous end-joining_Homo sapiens_hsa034500.96105499
69Nitrogen metabolism_Homo sapiens_hsa009100.94062373
70One carbon pool by folate_Homo sapiens_hsa006700.93519444
71Caffeine metabolism_Homo sapiens_hsa002320.93088949
72Thyroid hormone synthesis_Homo sapiens_hsa049180.92597278
73Calcium signaling pathway_Homo sapiens_hsa040200.90062940
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89590207
75Estrogen signaling pathway_Homo sapiens_hsa049150.88370836
76Arachidonic acid metabolism_Homo sapiens_hsa005900.88072931
77Sphingolipid metabolism_Homo sapiens_hsa006000.86803753
78cAMP signaling pathway_Homo sapiens_hsa040240.86189941
79Dilated cardiomyopathy_Homo sapiens_hsa054140.86111020
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84725567
81Bile secretion_Homo sapiens_hsa049760.83261978
82* Tryptophan metabolism_Homo sapiens_hsa003800.81598118
83Type I diabetes mellitus_Homo sapiens_hsa049400.81134062
84RNA polymerase_Homo sapiens_hsa030200.80914938
85Primary immunodeficiency_Homo sapiens_hsa053400.78132940
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77296192
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73759619
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73561318
89Alcoholism_Homo sapiens_hsa050340.72559088
90Prion diseases_Homo sapiens_hsa050200.70617571
91Peroxisome_Homo sapiens_hsa041460.70338500
92MAPK signaling pathway_Homo sapiens_hsa040100.70278818
93Graft-versus-host disease_Homo sapiens_hsa053320.69916216
94Choline metabolism in cancer_Homo sapiens_hsa052310.69285643
95Melanogenesis_Homo sapiens_hsa049160.67615047
96Circadian rhythm_Homo sapiens_hsa047100.65517089
97ErbB signaling pathway_Homo sapiens_hsa040120.63420768
98Lysine degradation_Homo sapiens_hsa003100.63125306
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61225442
100Steroid biosynthesis_Homo sapiens_hsa001000.60882779
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.60419451
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60342108
103Regulation of autophagy_Homo sapiens_hsa041400.58727043
104Axon guidance_Homo sapiens_hsa043600.58269286
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57242832
106Protein export_Homo sapiens_hsa030600.56667586
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.55731608
108Asthma_Homo sapiens_hsa053100.55217364
109Platelet activation_Homo sapiens_hsa046110.54774035
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54633898
111Fatty acid degradation_Homo sapiens_hsa000710.54569724
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.53098477
113Ovarian steroidogenesis_Homo sapiens_hsa049130.53033289
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52991211
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51687228
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50886063
117RNA degradation_Homo sapiens_hsa030180.50765923
118Oocyte meiosis_Homo sapiens_hsa041140.49972641
119Purine metabolism_Homo sapiens_hsa002300.49947047
120Arginine biosynthesis_Homo sapiens_hsa002200.49644792
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.49628785
122beta-Alanine metabolism_Homo sapiens_hsa004100.48065033
123Insulin signaling pathway_Homo sapiens_hsa049100.46818097
124Glucagon signaling pathway_Homo sapiens_hsa049220.46576201
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46093247
126Fat digestion and absorption_Homo sapiens_hsa049750.42362049
127Ras signaling pathway_Homo sapiens_hsa040140.42232365
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42112125
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40814386
130Glioma_Homo sapiens_hsa052140.39149195
131Fatty acid biosynthesis_Homo sapiens_hsa000610.37611062
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37163829
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36665998
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36488167
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36472633
136Pancreatic secretion_Homo sapiens_hsa049720.35915953
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35537178
138* Metabolic pathways_Homo sapiens_hsa011000.33555453
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31859382
140Hematopoietic cell lineage_Homo sapiens_hsa046400.31485660
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.31372128
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31353040
143mTOR signaling pathway_Homo sapiens_hsa041500.30809030
144African trypanosomiasis_Homo sapiens_hsa051430.28124320
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27341402
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24922167
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21522984
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21181059
149Glycerolipid metabolism_Homo sapiens_hsa005610.20672853
150Phagosome_Homo sapiens_hsa041450.18548729
151Parkinsons disease_Homo sapiens_hsa050120.18236751
152Endocytosis_Homo sapiens_hsa041440.18153951
153Fatty acid metabolism_Homo sapiens_hsa012120.17513926
154Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15976964
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.15770707

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