TPI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.90646651
2tricarboxylic acid cycle (GO:0006099)5.89792095
3ATP synthesis coupled proton transport (GO:0015986)5.33669178
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.33669178
5NADH metabolic process (GO:0006734)5.21847631
6* glycolytic process (GO:0006096)5.02490757
7oxaloacetate metabolic process (GO:0006107)4.84323990
8proteasome assembly (GO:0043248)4.74906853
9regulation of cofactor metabolic process (GO:0051193)4.71479653
10regulation of coenzyme metabolic process (GO:0051196)4.71479653
11establishment of integrated proviral latency (GO:0075713)4.65121367
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.59286744
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.46413804
14* gluconeogenesis (GO:0006094)4.37427601
15cullin deneddylation (GO:0010388)4.31505217
16oxidative phosphorylation (GO:0006119)4.27864725
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.27537400
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.23970874
19regulation of acyl-CoA biosynthetic process (GO:0050812)4.21179541
20synaptic vesicle exocytosis (GO:0016079)4.18461298
21* pyruvate metabolic process (GO:0006090)4.17499493
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.12623955
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12070605
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.09651668
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07989010
26negative regulation of ligase activity (GO:0051352)4.07989010
27sodium ion export (GO:0071436)4.06019704
28cell communication by electrical coupling (GO:0010644)4.05015889
29respiratory electron transport chain (GO:0022904)4.04570463
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.03748928
31muscle filament sliding (GO:0030049)4.01141573
32actin-myosin filament sliding (GO:0033275)4.01141573
33protein deneddylation (GO:0000338)3.97213414
34establishment of viral latency (GO:0019043)3.96019591
35regulation of cellular amino acid metabolic process (GO:0006521)3.95129436
36electron transport chain (GO:0022900)3.94916309
37* hexose biosynthetic process (GO:0019319)3.92939913
38succinate metabolic process (GO:0006105)3.92211142
39positive regulation of synapse maturation (GO:0090129)3.90893522
40DNA strand elongation involved in DNA replication (GO:0006271)3.89166681
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.80120762
42ATP biosynthetic process (GO:0006754)3.79486256
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.79418278
44cardiac muscle contraction (GO:0060048)3.77076451
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75886800
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75886800
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75886800
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74561919
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74561919
50telomere maintenance via semi-conservative replication (GO:0032201)3.74217376
51cellular potassium ion homeostasis (GO:0030007)3.72709985
52sarcomere organization (GO:0045214)3.70832012
53DNA strand elongation (GO:0022616)3.70524500
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65755958
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64552102
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.64552102
57* monosaccharide biosynthetic process (GO:0046364)3.63408205
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.61104896
59regulation of mitochondrial translation (GO:0070129)3.59587037
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57071455
61cardiac myofibril assembly (GO:0055003)3.55038014
62regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.53249420
63galactose catabolic process (GO:0019388)3.52943918
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.51691624
65L-serine metabolic process (GO:0006563)3.50438661
66DNA damage response, detection of DNA damage (GO:0042769)3.46235782
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44720045
68energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.43611100
69ATP hydrolysis coupled proton transport (GO:0015991)3.43611100
70tRNA aminoacylation for protein translation (GO:0006418)3.39999036
71positive regulation of ligase activity (GO:0051351)3.38642021
72chaperone-mediated protein transport (GO:0072321)3.37691080
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.37637588
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.37107472
754-hydroxyproline metabolic process (GO:0019471)3.35297261
76IMP biosynthetic process (GO:0006188)3.34606895
77amino acid activation (GO:0043038)3.34295574
78tRNA aminoacylation (GO:0043039)3.34295574
792-oxoglutarate metabolic process (GO:0006103)3.34245026
80regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.32302265
81purine nucleobase biosynthetic process (GO:0009113)3.31876885
82regulation of ubiquitin-protein transferase activity (GO:0051438)3.30601099
83CENP-A containing nucleosome assembly (GO:0034080)3.27111330
84aspartate family amino acid catabolic process (GO:0009068)3.25567911
85chromatin remodeling at centromere (GO:0031055)3.25376294
86lysine catabolic process (GO:0006554)3.24246481
87lysine metabolic process (GO:0006553)3.24246481
88ribosome assembly (GO:0042255)3.23222450
89spliceosomal snRNP assembly (GO:0000387)3.23029946
90striated muscle contraction (GO:0006941)3.17837403
91plasma membrane repair (GO:0001778)3.16682397
92DNA ligation (GO:0006266)3.16536118
93regulation of ligase activity (GO:0051340)3.16164401
94purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.14005079
95purine nucleoside monophosphate biosynthetic process (GO:0009127)3.14005079
96nucleobase biosynthetic process (GO:0046112)3.14002159
97mitotic metaphase plate congression (GO:0007080)3.13994322
98glutamate secretion (GO:0014047)3.13851319
99mitotic sister chromatid segregation (GO:0000070)3.11361590
100regulation of sulfur metabolic process (GO:0042762)3.09280045
101actin-mediated cell contraction (GO:0070252)3.08728613
102metaphase plate congression (GO:0051310)3.08579841
103telomere maintenance via recombination (GO:0000722)3.07804643
104purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.06687987
105protein targeting to mitochondrion (GO:0006626)3.05999533
106rRNA modification (GO:0000154)3.05445794
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05302132
108cell communication involved in cardiac conduction (GO:0086065)3.04282446
109protein complex biogenesis (GO:0070271)3.04136026
110purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03531865
111mitochondrial respiratory chain complex assembly (GO:0033108)3.01799829
112inner mitochondrial membrane organization (GO:0007007)3.01792014
113regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.01263926
114non-recombinational repair (GO:0000726)3.00527877
115double-strand break repair via nonhomologous end joining (GO:0006303)3.00527877
116mitotic recombination (GO:0006312)3.00316762
117DNA replication checkpoint (GO:0000076)2.99869437
118negative regulation of microtubule polymerization (GO:0031115)2.99719515
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.99532058
120termination of RNA polymerase III transcription (GO:0006386)2.99532058
121protein localization to kinetochore (GO:0034501)2.98770570
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97323936
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.97323936
124DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94917777
125respiratory chain complex IV assembly (GO:0008535)2.94404215
126regulation of cellular respiration (GO:0043457)2.94231995
127tricarboxylic acid metabolic process (GO:0072350)2.93945120
128synaptic vesicle maturation (GO:0016188)2.93395570
129aldehyde catabolic process (GO:0046185)2.93209285
130regulation of cellular amine metabolic process (GO:0033238)2.90790856
131regulation of skeletal muscle contraction (GO:0014819)2.90363560
132glycogen catabolic process (GO:0005980)2.90359251
133lactate metabolic process (GO:0006089)2.90233731
134protein localization to mitochondrion (GO:0070585)2.89974597
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.89797783
136negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89205260
137transcription-coupled nucleotide-excision repair (GO:0006283)2.89117453
138DNA double-strand break processing (GO:0000729)2.88486003
139protein hydroxylation (GO:0018126)2.88482862
140myofibril assembly (GO:0030239)2.88316632
141ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87426445
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.86386270
143establishment of protein localization to mitochondrion (GO:0072655)2.86161132
144vocalization behavior (GO:0071625)2.85869683
145neurotransmitter secretion (GO:0007269)2.84253084
146negative regulation of protein ubiquitination (GO:0031397)2.83276248
147cell cycle G1/S phase transition (GO:0044843)2.83248432
148G1/S transition of mitotic cell cycle (GO:0000082)2.83248432
1497-methylguanosine mRNA capping (GO:0006370)2.82184498
150DNA catabolic process, exonucleolytic (GO:0000738)2.81039237
151membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80979453
152regulation of synapse structural plasticity (GO:0051823)2.80139329
153IMP metabolic process (GO:0046040)2.79984708
154protein localization to synapse (GO:0035418)2.79293649
155peptidyl-histidine modification (GO:0018202)2.79278606
156positive regulation of cell cycle arrest (GO:0071158)2.78705836
157NADH dehydrogenase complex assembly (GO:0010257)2.77235213
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77235213
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.77235213
160formation of translation preinitiation complex (GO:0001731)2.77198049
161regulation of cell communication by electrical coupling (GO:0010649)2.76123863
162protein K6-linked ubiquitination (GO:0085020)2.74853350
163hydrogen ion transmembrane transport (GO:1902600)2.74647522
164glucan catabolic process (GO:0009251)2.74308755
165sister chromatid segregation (GO:0000819)2.73556318
166RNA capping (GO:0036260)2.73237303
1677-methylguanosine RNA capping (GO:0009452)2.73237303
168histone exchange (GO:0043486)2.72045367
169DNA replication-dependent nucleosome assembly (GO:0006335)2.71184469
170DNA replication-dependent nucleosome organization (GO:0034723)2.71184469
171ketone body metabolic process (GO:1902224)2.71081127
172peptidyl-proline hydroxylation (GO:0019511)2.70937218
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70004247
174peptidyl-arginine omega-N-methylation (GO:0035247)2.69726209
175* glucose metabolic process (GO:0006006)2.68582548
176striatum development (GO:0021756)2.68437362
177regulation of synaptic vesicle exocytosis (GO:2000300)2.66013231
178cellular sodium ion homeostasis (GO:0006883)2.63184565
179sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63101133
180muscle cell cellular homeostasis (GO:0046716)2.61465544
181regulation of membrane repolarization (GO:0060306)2.60833741
182regulation of calcium ion transmembrane transport (GO:1903169)2.60829262
183regulation of calcium ion transmembrane transporter activity (GO:1901019)2.60829262
184negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.60584708
185negative regulation of calcium ion transmembrane transport (GO:1903170)2.60584708
186positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.58453515
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57891355
188cellular polysaccharide catabolic process (GO:0044247)2.57112774
189gamma-aminobutyric acid signaling pathway (GO:0007214)2.56388106
190ribonucleoside monophosphate biosynthetic process (GO:0009156)2.55627772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.82285430
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.25694293
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.00509983
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.69175921
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21616618
6GABP_17652178_ChIP-ChIP_JURKAT_Human4.14616366
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.94778507
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35973823
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26057582
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88677125
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84572788
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.79447392
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78568204
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.68995388
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.53315302
16ELK1_19687146_ChIP-ChIP_HELA_Human2.51097783
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35582330
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34729781
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23825094
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.22550670
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.21055203
22ZNF263_19887448_ChIP-Seq_K562_Human2.20406316
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17676197
24VDR_23849224_ChIP-Seq_CD4+_Human2.15864055
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.12540253
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11082838
27FOXP3_21729870_ChIP-Seq_TREG_Human2.06867944
28GABP_19822575_ChIP-Seq_HepG2_Human2.06644794
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05931095
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04434678
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02573234
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.02335865
33* TTF2_22483619_ChIP-Seq_HELA_Human1.97317915
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95790884
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94842812
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.94394746
37CLOCK_20551151_ChIP-Seq_293T_Human1.90018800
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87148053
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86465137
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.85654780
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84113030
42LXR_22292898_ChIP-Seq_THP-1_Human1.81682587
43EZH2_22144423_ChIP-Seq_EOC_Human1.80970409
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77973758
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77220228
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76801704
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.73324559
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72553602
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72292845
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.72075453
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70799039
52* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69474178
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67535338
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67205520
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65140452
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63349018
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59120735
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58763075
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.58223831
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56491649
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53434909
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51500589
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49627200
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47830321
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47549376
66MYC_18940864_ChIP-ChIP_HL60_Human1.47178310
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46542238
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.45591611
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42854360
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42056653
71REST_21632747_ChIP-Seq_MESCs_Mouse1.40726393
72* XRN2_22483619_ChIP-Seq_HELA_Human1.38545901
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38468673
74CTCF_27219007_Chip-Seq_Bcells_Human1.36356663
75ZNF274_21170338_ChIP-Seq_K562_Hela1.36186965
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35370315
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35370315
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34688972
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33620026
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32745951
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31437755
82* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28369474
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28217100
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26741858
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25106444
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24358543
87KDM5A_27292631_Chip-Seq_BREAST_Human1.24162672
88P68_20966046_ChIP-Seq_HELA_Human1.21894501
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21196412
90ATF3_27146783_Chip-Seq_COLON_Human1.20830408
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.19917325
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19532751
93* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18380666
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18214452
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17461844
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17136083
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.17123769
98BCL6_27268052_Chip-Seq_Bcells_Human1.16844426
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15601025
100* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15396489
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.15028090
102DROSHA_22980978_ChIP-Seq_HELA_Human1.13799708
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13638460
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12286951
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.11987930
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.11932710
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11778531
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11656068
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11412550
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.11308345
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10848415
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10141623
113CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09993418
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09352241
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09259675
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.08912539
117PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07694783
118* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07477261
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06612327
120AR_21909140_ChIP-Seq_LNCAP_Human1.06218543
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06006353
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05868260
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05747584
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05738950
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05290575
126SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04190159
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.04016468
128JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03842702
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03135994
130SMC4_20622854_ChIP-Seq_HELA_Human1.02661963
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01791075
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01301637
133DCP1A_22483619_ChIP-Seq_HELA_Human1.01230553
134RACK7_27058665_Chip-Seq_MCF-7_Human1.01180992
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00865507
136* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00533239
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98666081
138CREB1_26743006_Chip-Seq_LNCaP_Human0.98181811
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.97895491
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97743400
141* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97002820
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96865571
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96506453
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95711883
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.94994510
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94812783
147TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94541799
148RXR_22158963_ChIP-Seq_LIVER_Mouse0.92967582
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92694789
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91824225
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91085132
152CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90319324
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90045613
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87446629
155ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85568006
156SALL1_21062744_ChIP-ChIP_HESCs_Human0.83631455
157EWS_26573619_Chip-Seq_HEK293_Human0.81375045
158CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80368039
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78269155
160IRF1_19129219_ChIP-ChIP_H3396_Human0.77604194
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76487831
162CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75182312
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72404275
164FUS_26573619_Chip-Seq_HEK293_Human0.70748118
165EOMES_21245162_ChIP-Seq_HESCs_Human0.70287779
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69923029
167ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68800430
168TFEB_21752829_ChIP-Seq_HELA_Human0.67946363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.61879373
2MP0000751_myopathy3.94181711
3MP0010094_abnormal_chromosome_stability3.81145036
4MP0004084_abnormal_cardiac_muscle3.79672555
5MP0008058_abnormal_DNA_repair3.77187293
6MP0003646_muscle_fatigue3.51241738
7MP0003693_abnormal_embryo_hatching3.25060917
8MP0004036_abnormal_muscle_relaxation3.20626066
9MP0004957_abnormal_blastocyst_morpholog3.03882094
10MP0004215_abnormal_myocardial_fiber2.95957276
11MP0003111_abnormal_nucleus_morphology2.94026019
12MP0004859_abnormal_synaptic_plasticity2.93061303
13MP0004233_abnormal_muscle_weight2.91505557
14MP0000749_muscle_degeneration2.83609521
15MP0003077_abnormal_cell_cycle2.79130124
16MP0008932_abnormal_embryonic_tissue2.75098379
17MP0002938_white_spotting2.43982805
18MP0004145_abnormal_muscle_electrophysio2.41823950
19MP0008007_abnormal_cellular_replicative2.15410731
20MP0005330_cardiomyopathy2.11820438
21MP0005620_abnormal_muscle_contractility2.08394164
22MP0002269_muscular_atrophy2.07562508
23MP0003635_abnormal_synaptic_transmissio2.05260906
24MP0000747_muscle_weakness2.04663845
25MP0003786_premature_aging2.03734959
26MP0008775_abnormal_heart_ventricle2.03235960
27MP0003880_abnormal_central_pattern2.00869818
28MP0003718_maternal_effect1.99885930
29MP0003186_abnormal_redox_activity1.99823550
30MP0004087_abnormal_muscle_fiber1.96217847
31MP0002822_catalepsy1.93538859
32MP0003136_yellow_coat_color1.89336971
33MP0006036_abnormal_mitochondrial_physio1.84083230
34MP0002972_abnormal_cardiac_muscle1.80537040
35MP0008789_abnormal_olfactory_epithelium1.78589789
36MP0000750_abnormal_muscle_regeneration1.78224178
37MP0002909_abnormal_adrenal_gland1.77531178
38MP0002106_abnormal_muscle_physiology1.77338343
39MP0006292_abnormal_olfactory_placode1.76798603
40MP0009697_abnormal_copulation1.75971341
41MP0002090_abnormal_vision1.73280768
42MP0005551_abnormal_eye_electrophysiolog1.72311213
43MP0005499_abnormal_olfactory_system1.70407450
44MP0005394_taste/olfaction_phenotype1.70407450
45MP0004484_altered_response_of1.65640016
46MP0002064_seizures1.65174622
47MP0009745_abnormal_behavioral_response1.64981333
48MP0003122_maternal_imprinting1.64077729
49MP0004147_increased_porphyrin_level1.63807632
50MP0002332_abnormal_exercise_endurance1.63323262
51MP0009046_muscle_twitch1.63231784
52MP0000759_abnormal_skeletal_muscle1.63071149
53MP0001293_anophthalmia1.62533019
54MP0002102_abnormal_ear_morphology1.61992937
55MP0002234_abnormal_pharynx_morphology1.61663736
56MP0004130_abnormal_muscle_cell1.61642069
57MP0003221_abnormal_cardiomyocyte_apopto1.59593033
58MP0005171_absent_coat_pigmentation1.58871859
59MP0002736_abnormal_nociception_after1.58035943
60MP0006035_abnormal_mitochondrial_morpho1.56911365
61MP0003123_paternal_imprinting1.56112670
62MP0001968_abnormal_touch/_nociception1.54597905
63MP0002063_abnormal_learning/memory/cond1.54297528
64MP0003137_abnormal_impulse_conducting1.51045988
65MP0003329_amyloid_beta_deposits1.50820095
66MP0001529_abnormal_vocalization1.47909466
67MP0005369_muscle_phenotype1.42327171
68MP0005385_cardiovascular_system_phenoty1.36651228
69MP0001544_abnormal_cardiovascular_syste1.36651228
70MP0003705_abnormal_hypodermis_morpholog1.36000061
71MP0004858_abnormal_nervous_system1.35446034
72MP0004085_abnormal_heartbeat1.34575407
73MP0005360_urolithiasis1.33317455
74MP0008877_abnormal_DNA_methylation1.27842533
75MP0006138_congestive_heart_failure1.27733133
76MP0000372_irregular_coat_pigmentation1.26841769
77MP0005408_hypopigmentation1.23553350
78MP0003937_abnormal_limbs/digits/tail_de1.23290308
79MP0002272_abnormal_nervous_system1.19352997
80MP0002233_abnormal_nose_morphology1.18774383
81MP0001346_abnormal_lacrimal_gland1.18254668
82MP0003567_abnormal_fetal_cardiomyocyte1.17958723
83MP0004043_abnormal_pH_regulation1.14180380
84MP0001764_abnormal_homeostasis1.12758178
85MP0010630_abnormal_cardiac_muscle1.12069511
86MP0010234_abnormal_vibrissa_follicle1.08551805
87MP0002572_abnormal_emotion/affect_behav1.07787584
88MP0001697_abnormal_embryo_size1.07733735
89MP0006072_abnormal_retinal_apoptosis1.07635640
90MP0001730_embryonic_growth_arrest1.06290823
91MP0000647_abnormal_sebaceous_gland1.05557729
92MP0004924_abnormal_behavior1.05356612
93MP0005386_behavior/neurological_phenoty1.05356612
94MP0002751_abnormal_autonomic_nervous1.04524361
95MP0000350_abnormal_cell_proliferation1.04142695
96MP0005266_abnormal_metabolism1.02693791
97MP0002067_abnormal_sensory_capabilities1.02234511
98MP0001440_abnormal_grooming_behavior1.02230834
99MP0001984_abnormal_olfaction1.02221884
100MP0002734_abnormal_mechanical_nocicepti1.01139662
101MP0000013_abnormal_adipose_tissue1.00773682
102MP0004270_analgesia0.99953400
103MP0000566_synostosis0.98655526
104MP0001501_abnormal_sleep_pattern0.98065070
105MP0002210_abnormal_sex_determination0.97832311
106MP0002089_abnormal_postnatal_growth/wei0.97736168
107MP0008872_abnormal_physiological_respon0.97690970
108MP0003121_genomic_imprinting0.96045138
109MP0002085_abnormal_embryonic_tissue0.95910188
110MP0003941_abnormal_skin_development0.95310309
111MP0002697_abnormal_eye_size0.91324899
112MP0003315_abnormal_perineum_morphology0.90875545
113MP0004133_heterotaxia0.90821386
114MP0001672_abnormal_embryogenesis/_devel0.90778613
115MP0005380_embryogenesis_phenotype0.90778613
116* MP0002080_prenatal_lethality0.90335001
117MP0003283_abnormal_digestive_organ0.89504592
118MP0001286_abnormal_eye_development0.89256429
119MP0002282_abnormal_trachea_morphology0.87855126
120MP0005084_abnormal_gallbladder_morpholo0.86955934
121MP0003806_abnormal_nucleotide_metabolis0.86705395
122MP0004811_abnormal_neuron_physiology0.86147695
123MP0002163_abnormal_gland_morphology0.86120923
124MP0001929_abnormal_gametogenesis0.84867413
125MP0002735_abnormal_chemical_nociception0.84638095
126MP0002084_abnormal_developmental_patter0.84200190
127MP0002638_abnormal_pupillary_reflex0.83245233
128MP0000579_abnormal_nail_morphology0.82409236
129MP0002184_abnormal_innervation0.82000981
130MP0005623_abnormal_meninges_morphology0.81484515
131MP0003755_abnormal_palate_morphology0.80522488
132MP0010030_abnormal_orbit_morphology0.79760941
133MP0000537_abnormal_urethra_morphology0.79392277
134MP0002127_abnormal_cardiovascular_syste0.79128625
135MP0005391_vision/eye_phenotype0.78919870
136MP0001299_abnormal_eye_distance/0.78839221
137MP0008569_lethality_at_weaning0.78738773
138MP0008057_abnormal_DNA_replication0.78223914
139MP0000653_abnormal_sex_gland0.77729235
140MP0008995_early_reproductive_senescence0.77247026
141MP0000358_abnormal_cell_content/0.76441598
142MP0004272_abnormal_basement_membrane0.75712453
143MP0005332_abnormal_amino_acid0.75516157
144MP0001324_abnormal_eye_pigmentation0.74994242
145MP0004142_abnormal_muscle_tone0.74944858
146MP0009672_abnormal_birth_weight0.74644774
147MP0001145_abnormal_male_reproductive0.74211851
148MP0000313_abnormal_cell_death0.73944645
149MP0005253_abnormal_eye_physiology0.72434681
150MP0000049_abnormal_middle_ear0.72350071
151MP0002066_abnormal_motor_capabilities/c0.72223333
152MP0003984_embryonic_growth_retardation0.71754921
153MP0003938_abnormal_ear_development0.71515905
154MP0005187_abnormal_penis_morphology0.71357942
155MP0003879_abnormal_hair_cell0.69767056
156MP0002088_abnormal_embryonic_growth/wei0.69557921
157MP0010329_abnormal_lipoprotein_level0.69088297
158MP0002111_abnormal_tail_morphology0.68679664
159MP0005670_abnormal_white_adipose0.66916381
160MP0005367_renal/urinary_system_phenotyp0.66901541
161MP0000516_abnormal_urinary_system0.66901541
162MP0000230_abnormal_systemic_arterial0.66608893
163MP0005666_abnormal_adipose_tissue0.65861178
164MP0002139_abnormal_hepatobiliary_system0.65736859
165MP0001727_abnormal_embryo_implantation0.65577280
166MP0003011_delayed_dark_adaptation0.64461715
167MP0005535_abnormal_body_temperature0.64023693
168MP0006276_abnormal_autonomic_nervous0.63129882
169MP0001970_abnormal_pain_threshold0.62511517
170MP0001502_abnormal_circadian_rhythm0.61214494
171MP0000604_amyloidosis0.60552902
172MP0008961_abnormal_basal_metabolism0.59897216

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.63174559
2Myoglobinuria (HP:0002913)5.36458424
3Exercise-induced myalgia (HP:0003738)4.77382574
4Abnormality of glycolysis (HP:0004366)4.22925132
5Increased serum pyruvate (HP:0003542)4.22925132
6Rhabdomyolysis (HP:0003201)4.22897109
7Sudden death (HP:0001699)4.13372342
8Abnormal mitochondria in muscle tissue (HP:0008316)3.86522100
9Acute necrotizing encephalopathy (HP:0006965)3.59085807
10Central scotoma (HP:0000603)3.51138892
11Calf muscle hypertrophy (HP:0008981)3.50681578
12Muscle hypertrophy of the lower extremities (HP:0008968)3.44623021
13Congenital stationary night blindness (HP:0007642)3.39388262
14Muscle stiffness (HP:0003552)3.35862986
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29286420
16Abnormality of the labia minora (HP:0012880)3.25450240
17Visual hallucinations (HP:0002367)3.24894429
18Abnormality of the calf musculature (HP:0001430)3.21522306
19Increased hepatocellular lipid droplets (HP:0006565)3.20701337
20Mitochondrial inheritance (HP:0001427)3.18722022
21Acute encephalopathy (HP:0006846)3.15380248
22Hepatocellular necrosis (HP:0001404)3.14391831
23Ragged-red muscle fibers (HP:0003200)3.10322700
24Palpitations (HP:0001962)3.09448909
25Type 1 muscle fiber predominance (HP:0003803)3.06058410
26Meckel diverticulum (HP:0002245)3.05022731
27Increased CSF lactate (HP:0002490)3.02010020
28Pheochromocytoma (HP:0002666)3.00737925
29Exercise intolerance (HP:0003546)2.95099527
30Progressive macrocephaly (HP:0004481)2.95079993
31Chromsome breakage (HP:0040012)2.93144600
32Abnormality of the ileum (HP:0001549)2.91980196
33EMG: myopathic abnormalities (HP:0003458)2.91158806
34Lipid accumulation in hepatocytes (HP:0006561)2.88640389
35Abnormality of the anterior horn cell (HP:0006802)2.87680125
36Degeneration of anterior horn cells (HP:0002398)2.87680125
37Colon cancer (HP:0003003)2.85048901
38Focal motor seizures (HP:0011153)2.84872856
39Myokymia (HP:0002411)2.84856065
40Hepatic necrosis (HP:0002605)2.84059866
41Myotonia (HP:0002486)2.74239165
42Neuroendocrine neoplasm (HP:0100634)2.73867952
43Microvesicular hepatic steatosis (HP:0001414)2.68356646
44Type I transferrin isoform profile (HP:0003642)2.65531820
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.64635271
46Increased muscle lipid content (HP:0009058)2.63517347
47Asymmetric septal hypertrophy (HP:0001670)2.62548833
48Cerebral edema (HP:0002181)2.61108802
49Conjunctival hamartoma (HP:0100780)2.60805190
50Increased intramyocellular lipid droplets (HP:0012240)2.59527384
51Abnormality of the preputium (HP:0100587)2.58306536
52Emotional lability (HP:0000712)2.53579141
53Renal Fanconi syndrome (HP:0001994)2.53033476
54Ependymoma (HP:0002888)2.50415972
55Lactic acidosis (HP:0003128)2.47621706
56Muscle fiber inclusion bodies (HP:0100299)2.46747001
57Absence seizures (HP:0002121)2.43532023
58Reticulocytopenia (HP:0001896)2.41724159
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39534664
60Increased connective tissue (HP:0009025)2.38884542
61Atrial fibrillation (HP:0005110)2.37995105
62Hyperglycinemia (HP:0002154)2.35556380
63Angiofibromas (HP:0010615)2.34794793
64Adenoma sebaceum (HP:0009720)2.34794793
65Limb-girdle muscle atrophy (HP:0003797)2.34514699
66Ventricular fibrillation (HP:0001663)2.33357489
67Dysmetric saccades (HP:0000641)2.33194091
68Supraventricular tachycardia (HP:0004755)2.33134900
69Ventricular tachycardia (HP:0004756)2.32403378
70Abnormality of methionine metabolism (HP:0010901)2.31401083
71Hypoplastic pelvis (HP:0008839)2.30920549
72Primary atrial arrhythmia (HP:0001692)2.30825387
73Scotoma (HP:0000575)2.30178667
74Supraventricular arrhythmia (HP:0005115)2.29070440
75Lipoatrophy (HP:0100578)2.28761685
76Difficulty climbing stairs (HP:0003551)2.25361560
77Postnatal microcephaly (HP:0005484)2.24017177
78Syncope (HP:0001279)2.23894660
79Ketoacidosis (HP:0001993)2.23031704
80Abnormality of chromosome stability (HP:0003220)2.22806919
81Ventricular arrhythmia (HP:0004308)2.22629713
82Respiratory failure (HP:0002878)2.22607525
83Gout (HP:0001997)2.21175681
84* Abnormal gallbladder physiology (HP:0012438)2.20814072
85* Cholecystitis (HP:0001082)2.20814072
86Muscle fiber splitting (HP:0003555)2.18692440
87Increased variability in muscle fiber diameter (HP:0003557)2.17311241
88Shoulder girdle muscle weakness (HP:0003547)2.16999212
89Cerebral hypomyelination (HP:0006808)2.16671905
90Abnormal lung lobation (HP:0002101)2.16515606
91Neoplasm of the peripheral nervous system (HP:0100007)2.14527881
92Prolonged QT interval (HP:0001657)2.12886005
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12856095
94Abnormal protein N-linked glycosylation (HP:0012347)2.12856095
95Abnormal protein glycosylation (HP:0012346)2.12856095
96Abnormal glycosylation (HP:0012345)2.12856095
97Resting tremor (HP:0002322)2.11287870
98Hamartoma of the eye (HP:0010568)2.11031206
99Myopathic facies (HP:0002058)2.10822268
100Methylmalonic aciduria (HP:0012120)2.10636852
101Leukodystrophy (HP:0002415)2.10113594
102Hyporeflexia of lower limbs (HP:0002600)2.09438283
103Difficulty running (HP:0009046)2.09089549
104Increased serum lactate (HP:0002151)2.08566170
105Neoplasm of the adrenal gland (HP:0100631)2.06632174
106Abnormality of the lower motor neuron (HP:0002366)2.05903105
107Rimmed vacuoles (HP:0003805)2.05569934
108Duodenal stenosis (HP:0100867)2.05459665
109Small intestinal stenosis (HP:0012848)2.05459665
110Distal arthrogryposis (HP:0005684)2.04950381
111Athetosis (HP:0002305)2.04266229
112Centrally nucleated skeletal muscle fibers (HP:0003687)2.04081135
113Epileptic encephalopathy (HP:0200134)2.04071395
114Abnormality of skeletal muscle fiber size (HP:0012084)2.03934755
115Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03571652
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03571652
117Subaortic stenosis (HP:0001682)2.02571337
118Abnormality of the left ventricular outflow tract (HP:0011103)2.02571337
119Reticulocytosis (HP:0001923)2.02163188
120Right ventricular cardiomyopathy (HP:0011663)2.01831726
121Horseshoe kidney (HP:0000085)2.01694272
122True hermaphroditism (HP:0010459)1.99474635
123Nemaline bodies (HP:0003798)1.99167814
124Methylmalonic acidemia (HP:0002912)1.98506782
125Lethargy (HP:0001254)1.97753637
126CNS demyelination (HP:0007305)1.97665042
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96467660
128Bifid tongue (HP:0010297)1.96266337
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94969769
130Abnormality of alanine metabolism (HP:0010916)1.94969769
131Hyperalaninemia (HP:0003348)1.94969769
132Focal seizures (HP:0007359)1.93780973
133Round ear (HP:0100830)1.93406322
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92999400
1353-Methylglutaconic aciduria (HP:0003535)1.92912040
136Achilles tendon contracture (HP:0001771)1.91471228
137Dialeptic seizures (HP:0011146)1.90921920
138Atonic seizures (HP:0010819)1.90543311
139Depression (HP:0000716)1.90371003
140Generalized tonic-clonic seizures (HP:0002069)1.90172651
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89428157
142Ketosis (HP:0001946)1.89328434
143Abnormality of glycine metabolism (HP:0010895)1.88593150
144Abnormality of serine family amino acid metabolism (HP:0010894)1.88593150
145Abnormality of serum amino acid levels (HP:0003112)1.87814709
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85438174
147Pancreatic fibrosis (HP:0100732)1.85107043
148* Optic disc pallor (HP:0000543)1.84029869
149Abnormality of the duodenum (HP:0002246)1.83746513
150X-linked dominant inheritance (HP:0001423)1.81323595
151Pancreatic cysts (HP:0001737)1.80954838
152Hyperglycinuria (HP:0003108)1.78110054
153Poor suck (HP:0002033)1.77677009
154Preaxial hand polydactyly (HP:0001177)1.77516791
155CNS hypomyelination (HP:0003429)1.77441563
156Absent radius (HP:0003974)1.76441164
157Abnormality of placental membranes (HP:0011409)1.74971356
158Amniotic constriction ring (HP:0009775)1.74971356
159Sclerocornea (HP:0000647)1.74780372
160Respiratory difficulties (HP:0002880)1.74687128
161Reduced antithrombin III activity (HP:0001976)1.73164331
162Sloping forehead (HP:0000340)1.72641363
163Birth length less than 3rd percentile (HP:0003561)1.72415135
164Pancytopenia (HP:0001876)1.71920621
165Astrocytoma (HP:0009592)1.70643052
166Abnormality of the astrocytes (HP:0100707)1.70643052
167Triphalangeal thumb (HP:0001199)1.69503070
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.69424076
169Absent forearm bone (HP:0003953)1.68873626
170Aplasia involving forearm bones (HP:0009822)1.68873626
171Abnormality of the carotid arteries (HP:0005344)1.66972055
172Secondary amenorrhea (HP:0000869)1.66016497
173Cortical dysplasia (HP:0002539)1.64799032
174Medial flaring of the eyebrow (HP:0010747)1.62886110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.77023913
2PKN24.33243579
3VRK24.01562489
4PBK3.08470684
5NME12.98431958
6SRPK12.87047937
7TRIM282.84930483
8EIF2AK12.65145884
9TRIB32.63387895
10OBSCN2.57178967
11TTN2.51587123
12MAP3K92.41619065
13CDC72.31359113
14STK162.24781253
15KSR22.18638640
16TTK2.16567774
17MAP3K42.16074095
18PLK32.14550424
19PDK32.13833887
20PDK42.13833887
21PHKG22.13702437
22PHKG12.13702437
23EIF2AK32.10315959
24ZAK2.06091911
25MST42.06055530
26VRK12.05798360
27MINK11.98570787
28BCKDK1.94302456
29MAP3K121.93911085
30LMTK21.90108309
31ARAF1.81279096
32NTRK31.80540392
33EPHA41.76239999
34MAP2K41.75636647
35PAK61.71909902
36NME21.66417340
37MYLK1.59036636
38KSR11.58105010
39PLK41.57681561
40MAP4K21.52030184
41NUAK11.48870763
42BCR1.43246159
43BRSK21.40811859
44SCYL21.40715353
45PLK11.38191591
46MST1R1.36962833
47FLT31.32209370
48DAPK11.31949705
49MKNK11.30527354
50RIPK11.23615568
51DAPK31.23313259
52CDK191.21290839
53CSNK1G31.18160845
54TAF11.16322579
55BMPR1B1.14582926
56EEF2K1.12545137
57DAPK21.11639034
58MKNK21.11105201
59CAMKK11.09890376
60PLK21.06202985
61PTK2B1.05901586
62TAOK21.04816081
63CSNK1G11.04695218
64LATS20.99374478
65ILK0.97043515
66SIK30.96065481
67STK380.95320781
68CSNK1A1L0.93988968
69TSSK60.93896438
70MAP3K110.92743817
71CSNK1G20.91937782
72MAP3K70.91561637
73AURKB0.90559752
74ATR0.90439931
75DYRK20.88972894
76PAK40.86250358
77RAF10.84027583
78TESK10.83641449
79CHEK20.83603206
80CDK140.83053883
81CDK150.82807922
82CDK180.82310616
83MAP2K70.81622888
84TNIK0.80835591
85ERBB40.78096859
86CDK80.77770391
87CASK0.77092030
88FGFR10.76553752
89ERBB30.75750750
90FER0.75459400
91MAP2K30.73224892
92WEE10.73149157
93BMX0.72752890
94EIF2AK20.72410753
95MAP2K10.72081005
96PDK20.72080597
97CDK11A0.71741905
98AKT20.70272905
99GRK60.70124449
100LIMK10.69761296
101WNK40.69102009
102CCNB10.69020519
103RET0.68840683
104STK38L0.68594930
105PRKCG0.68448972
106NTRK10.66707953
107AURKA0.66485368
108GRK50.66113826
109PAK30.64232284
110PINK10.60563032
111NEK20.59510786
112ROCK20.58881912
113CDK50.57996513
114CDK70.57906342
115CAMKK20.56811910
116BRAF0.56295144
117CAMK2A0.55316667
118CAMK2D0.53604755
119TLK10.52902762
120PIM20.52448254
121CHEK10.52418061
122BUB10.51934026
123MAP3K50.51334042
124ATM0.49691393
125BRSK10.49410371
126PRKD30.49276883
127CSNK2A10.49191565
128LRRK20.47830798
129CAMK10.47180612
130PRKCI0.47112333
131MOS0.47092685
132PASK0.45226412
133STK40.45030880
134CSNK2A20.44921980
135MAP3K130.44706796
136EPHA20.43253358
137MAP2K60.43095314
138ROCK10.39740474
139STK390.38712462
140RPS6KB20.38546505
141INSRR0.38096501
142RPS6KA40.37300203
143WNK30.36848741
144MAPK120.35999137
145OXSR10.35360018
146MAPKAPK50.34729067
147MAP3K10.34572533
148EPHB20.33565254
149TAOK10.33394703
150ADRBK10.32164193
151TGFBR10.32057090
152PTK60.31932925
153ALK0.31549719
154PRKG20.31138066
155CDK10.30558432
156RPS6KA50.30312059
157MAPKAPK30.29964231
158PAK10.29456842
159MET0.27847002
160TESK20.27580270
161MAP3K80.27122737
162CAMK2G0.26746969
163RIPK40.25701711

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.65213200
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81213788
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19877537
4Mismatch repair_Homo sapiens_hsa034303.04339271
5DNA replication_Homo sapiens_hsa030303.03754408
6Oxidative phosphorylation_Homo sapiens_hsa001903.01330786
7Cardiac muscle contraction_Homo sapiens_hsa042602.87849246
8* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.80664887
9Parkinsons disease_Homo sapiens_hsa050122.74627291
10* Carbon metabolism_Homo sapiens_hsa012002.70538815
11Synaptic vesicle cycle_Homo sapiens_hsa047212.62383029
12* Biosynthesis of amino acids_Homo sapiens_hsa012302.54515277
13Pyruvate metabolism_Homo sapiens_hsa006202.48256704
14Protein export_Homo sapiens_hsa030602.33487164
15Base excision repair_Homo sapiens_hsa034102.31222710
16RNA polymerase_Homo sapiens_hsa030202.26550594
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22082038
18Alzheimers disease_Homo sapiens_hsa050102.08410183
19Non-homologous end-joining_Homo sapiens_hsa034502.07609194
20Homologous recombination_Homo sapiens_hsa034402.07339276
21Nicotine addiction_Homo sapiens_hsa050331.84341819
22Fatty acid elongation_Homo sapiens_hsa000621.83936640
23Collecting duct acid secretion_Homo sapiens_hsa049661.77837567
24Fanconi anemia pathway_Homo sapiens_hsa034601.76865358
25Ribosome_Homo sapiens_hsa030101.76731959
26Nucleotide excision repair_Homo sapiens_hsa034201.74483165
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74092877
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72794234
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71047068
30Propanoate metabolism_Homo sapiens_hsa006401.67762595
31Spliceosome_Homo sapiens_hsa030401.67584719
32One carbon pool by folate_Homo sapiens_hsa006701.66364532
33Huntingtons disease_Homo sapiens_hsa050161.65838917
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64166159
35Pyrimidine metabolism_Homo sapiens_hsa002401.64031992
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.60675542
37RNA transport_Homo sapiens_hsa030131.58952487
38Galactose metabolism_Homo sapiens_hsa000521.53084077
39Steroid biosynthesis_Homo sapiens_hsa001001.50161731
40Dilated cardiomyopathy_Homo sapiens_hsa054141.45347358
41GABAergic synapse_Homo sapiens_hsa047271.42864663
42Pentose phosphate pathway_Homo sapiens_hsa000301.42521400
43* Fructose and mannose metabolism_Homo sapiens_hsa000511.37053829
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37022786
45RNA degradation_Homo sapiens_hsa030181.34120965
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33814496
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33747929
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33740906
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33246210
50Vitamin B6 metabolism_Homo sapiens_hsa007501.27594550
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24886511
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.21854941
53Cell cycle_Homo sapiens_hsa041101.21845381
54Arginine biosynthesis_Homo sapiens_hsa002201.21501410
55Circadian entrainment_Homo sapiens_hsa047131.21167973
56Glutathione metabolism_Homo sapiens_hsa004801.19570498
57Purine metabolism_Homo sapiens_hsa002301.19156110
58Glucagon signaling pathway_Homo sapiens_hsa049221.16977498
59Basal transcription factors_Homo sapiens_hsa030221.16872304
60Vibrio cholerae infection_Homo sapiens_hsa051101.12927652
61Fatty acid degradation_Homo sapiens_hsa000711.12116831
62Olfactory transduction_Homo sapiens_hsa047401.11280407
63Folate biosynthesis_Homo sapiens_hsa007901.11082197
64HIF-1 signaling pathway_Homo sapiens_hsa040661.06680213
65Morphine addiction_Homo sapiens_hsa050321.04236599
66Butanoate metabolism_Homo sapiens_hsa006501.01354796
67Long-term potentiation_Homo sapiens_hsa047201.00901767
68Oxytocin signaling pathway_Homo sapiens_hsa049210.99805425
69Phenylalanine metabolism_Homo sapiens_hsa003600.99083411
70Salivary secretion_Homo sapiens_hsa049700.93799751
71Dopaminergic synapse_Homo sapiens_hsa047280.92762303
72Sulfur relay system_Homo sapiens_hsa041220.91954512
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.90610113
74Selenocompound metabolism_Homo sapiens_hsa004500.90531232
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90430144
76Renin secretion_Homo sapiens_hsa049240.90414041
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89484664
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89333649
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88867967
80Insulin secretion_Homo sapiens_hsa049110.87022280
81Fatty acid metabolism_Homo sapiens_hsa012120.85942771
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85718157
83Starch and sucrose metabolism_Homo sapiens_hsa005000.84093934
84Tyrosine metabolism_Homo sapiens_hsa003500.83777775
85Gastric acid secretion_Homo sapiens_hsa049710.82806520
86Amphetamine addiction_Homo sapiens_hsa050310.81616181
87Calcium signaling pathway_Homo sapiens_hsa040200.79589900
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74008627
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72873334
90N-Glycan biosynthesis_Homo sapiens_hsa005100.70127467
91Peroxisome_Homo sapiens_hsa041460.69701312
92Bile secretion_Homo sapiens_hsa049760.69567310
93Proteasome_Homo sapiens_hsa030500.69076467
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67813023
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66460077
96Cholinergic synapse_Homo sapiens_hsa047250.65460675
97Gap junction_Homo sapiens_hsa045400.63054316
98Glutamatergic synapse_Homo sapiens_hsa047240.60756844
99Phototransduction_Homo sapiens_hsa047440.60383860
100Sulfur metabolism_Homo sapiens_hsa009200.59625161
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59307958
102Insulin signaling pathway_Homo sapiens_hsa049100.59210506
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58984010
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58028214
105mRNA surveillance pathway_Homo sapiens_hsa030150.54364611
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53488669
107GnRH signaling pathway_Homo sapiens_hsa049120.52991730
108Arginine and proline metabolism_Homo sapiens_hsa003300.50801162
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48006220
110Oocyte meiosis_Homo sapiens_hsa041140.47900970
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47406544
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47251782
113Nitrogen metabolism_Homo sapiens_hsa009100.44679829
114Taste transduction_Homo sapiens_hsa047420.43922316
115Long-term depression_Homo sapiens_hsa047300.43860642
116p53 signaling pathway_Homo sapiens_hsa041150.43049400
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42501840
118beta-Alanine metabolism_Homo sapiens_hsa004100.41548585
119PPAR signaling pathway_Homo sapiens_hsa033200.39927367
120AMPK signaling pathway_Homo sapiens_hsa041520.39847136
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39262147
122Serotonergic synapse_Homo sapiens_hsa047260.39056550
123Melanogenesis_Homo sapiens_hsa049160.38743020
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37382292
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36508859
126Glioma_Homo sapiens_hsa052140.35807806
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.35240564
128* Metabolic pathways_Homo sapiens_hsa011000.32933202
129Type II diabetes mellitus_Homo sapiens_hsa049300.31170808
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.30754143
131Thyroid hormone synthesis_Homo sapiens_hsa049180.30591772
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30431088
133Alcoholism_Homo sapiens_hsa050340.30019956
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29060800
135Estrogen signaling pathway_Homo sapiens_hsa049150.27823677
136mTOR signaling pathway_Homo sapiens_hsa041500.27784883
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26799231
138Basal cell carcinoma_Homo sapiens_hsa052170.26651788
139Tryptophan metabolism_Homo sapiens_hsa003800.26600666
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.26457542
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25170470
142Bladder cancer_Homo sapiens_hsa052190.25151489
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.22419771
144Fat digestion and absorption_Homo sapiens_hsa049750.21910348
145Hedgehog signaling pathway_Homo sapiens_hsa043400.21809499
146Cocaine addiction_Homo sapiens_hsa050300.21069436
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20627647
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19982656
149Lysine degradation_Homo sapiens_hsa003100.19121040
150Mineral absorption_Homo sapiens_hsa049780.18353283
151Hippo signaling pathway_Homo sapiens_hsa043900.18023275
152Vitamin digestion and absorption_Homo sapiens_hsa049770.15584740
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15355533
154Epstein-Barr virus infection_Homo sapiens_hsa051690.13342034

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