TPI1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.61890683
2cytidine deamination (GO:0009972)6.02937144
3cytidine metabolic process (GO:0046087)6.02937144
4cytidine catabolic process (GO:0006216)6.02937144
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.87347114
6proteasome assembly (GO:0043248)5.25660597
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.15556813
8regulation of cellular amino acid metabolic process (GO:0006521)4.63575379
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.48124998
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.30172080
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25910867
12water-soluble vitamin biosynthetic process (GO:0042364)4.22654703
13signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.19864184
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.19864184
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.19864184
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.19106927
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.19106927
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.09545050
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.08678715
20signal transduction involved in DNA integrity checkpoint (GO:0072401)4.02275789
21signal transduction involved in DNA damage checkpoint (GO:0072422)4.02275789
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01919173
23negative regulation of ligase activity (GO:0051352)4.00131456
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.00131456
25signal transduction involved in cell cycle checkpoint (GO:0072395)3.98265278
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96944745
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96944745
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.96736442
29regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.87581927
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83908151
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.76474305
32protein complex biogenesis (GO:0070271)3.73586864
33ATP synthesis coupled proton transport (GO:0015986)3.71444064
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71444064
35regulation of chronic inflammatory response (GO:0002676)3.65627184
36chaperone-mediated protein transport (GO:0072321)3.63830579
37GTP biosynthetic process (GO:0006183)3.58539274
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.54314874
39cellular response to interleukin-15 (GO:0071350)3.52018286
40mitochondrial respiratory chain complex assembly (GO:0033108)3.48860359
41antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.45611999
42positive regulation of ligase activity (GO:0051351)3.43523301
43regulation of isotype switching to IgG isotypes (GO:0048302)3.40125128
44regulation of cellular amine metabolic process (GO:0033238)3.39170531
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34100047
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.34100047
47NADH dehydrogenase complex assembly (GO:0010257)3.34100047
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32880697
49platelet dense granule organization (GO:0060155)3.30145357
50positive regulation of cell cycle arrest (GO:0071158)3.28955691
51DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.27174650
52protein deneddylation (GO:0000338)3.24690318
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23506583
54regulation of activation of Janus kinase activity (GO:0010533)3.20025272
55cullin deneddylation (GO:0010388)3.18637221
56respiratory chain complex IV assembly (GO:0008535)3.14668442
57response to pheromone (GO:0019236)3.08750066
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05148920
59electron transport chain (GO:0022900)3.04503267
60respiratory electron transport chain (GO:0022904)3.03954667
61pseudouridine synthesis (GO:0001522)3.01977492
62antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.96452753
63cytochrome complex assembly (GO:0017004)2.95546320
64DNA double-strand break processing (GO:0000729)2.95204089
65regulation of ubiquitin-protein transferase activity (GO:0051438)2.94858027
66termination of RNA polymerase III transcription (GO:0006386)2.94324287
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.94324287
68UTP biosynthetic process (GO:0006228)2.93920647
69rRNA modification (GO:0000154)2.91394007
70regulation of ligase activity (GO:0051340)2.88458504
71regulation of immunoglobulin secretion (GO:0051023)2.84242575
72DNA catabolic process, exonucleolytic (GO:0000738)2.84185563
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79576243
74pyrimidine ribonucleoside metabolic process (GO:0046131)2.79021441
75Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77269516
76negative regulation of protein ubiquitination (GO:0031397)2.75329878
77negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.70964892
78negative regulation of cell cycle G1/S phase transition (GO:1902807)2.70964892
79regulation of cell cycle arrest (GO:0071156)2.70751613
80negative regulation by host of viral transcription (GO:0043922)2.69573839
81maturation of 5.8S rRNA (GO:0000460)2.69000163
82response to interleukin-15 (GO:0070672)2.68767325
83amino acid salvage (GO:0043102)2.65422159
84L-methionine salvage (GO:0071267)2.65422159
85L-methionine biosynthetic process (GO:0071265)2.65422159
86tRNA processing (GO:0008033)2.65365180
87protein targeting to mitochondrion (GO:0006626)2.64938911
88base-excision repair, AP site formation (GO:0006285)2.63158509
89signal transduction in response to DNA damage (GO:0042770)2.63148577
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63073777
91rRNA methylation (GO:0031167)2.61006808
92protein neddylation (GO:0045116)2.60638506
93aldehyde catabolic process (GO:0046185)2.60028081
94purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58630875
95signal peptide processing (GO:0006465)2.58362881
96tRNA metabolic process (GO:0006399)2.57728242
97negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.57369304
98mannosylation (GO:0097502)2.56199288
99UTP metabolic process (GO:0046051)2.54922684
100positive regulation of defense response to virus by host (GO:0002230)2.54742600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12296444
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.33034249
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.85082063
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84321953
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.83025883
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80614898
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.59663538
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33251937
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12966755
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81586997
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72010470
12VDR_23849224_ChIP-Seq_CD4+_Human2.68245162
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.63360801
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60265447
15ELK1_19687146_ChIP-ChIP_HELA_Human2.53574898
16ZNF274_21170338_ChIP-Seq_K562_Hela2.47975262
17VDR_22108803_ChIP-Seq_LS180_Human2.35017555
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31924606
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29608578
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.28575627
21FOXP3_21729870_ChIP-Seq_TREG_Human2.23028385
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.16771528
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.07711398
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04762237
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92458835
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.89777486
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87588713
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78190759
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.71248719
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71091678
31MYC_18940864_ChIP-ChIP_HL60_Human1.70622640
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63580851
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60636693
34IGF1R_20145208_ChIP-Seq_DFB_Human1.60487302
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60402098
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.56234594
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55988126
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54415121
39DCP1A_22483619_ChIP-Seq_HELA_Human1.47694993
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44342784
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41742790
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.40665570
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39664909
44GABP_19822575_ChIP-Seq_HepG2_Human1.38679569
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38078454
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35165390
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33863759
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32995855
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30095481
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29479306
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29032098
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28155393
53TP53_22573176_ChIP-Seq_HFKS_Human1.26768229
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23719501
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22000536
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21914962
57EWS_26573619_Chip-Seq_HEK293_Human1.21161054
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19820682
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18642558
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18259765
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.14856786
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14620216
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.14619182
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14619182
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13781798
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11817519
67GATA3_26560356_Chip-Seq_TH2_Human1.11789467
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.10232620
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10038606
70AR_20517297_ChIP-Seq_VCAP_Human1.09820524
71MYB_26560356_Chip-Seq_TH2_Human1.09674903
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09587090
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08206276
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07046239
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04766777
76IRF1_19129219_ChIP-ChIP_H3396_Human1.04267920
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04139945
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02673686
79NANOG_19829295_ChIP-Seq_ESCs_Human1.02323439
80SOX2_19829295_ChIP-Seq_ESCs_Human1.02323439
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02004602
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01883091
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00391853
84TTF2_22483619_ChIP-Seq_HELA_Human0.99238739
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98758418
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97225770
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.96545127
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95822736
89P300_19829295_ChIP-Seq_ESCs_Human0.95739844
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.94446273
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93508957
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92907709
93E2F7_22180533_ChIP-Seq_HELA_Human0.92252748
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91478927
95ERG_20517297_ChIP-Seq_VCAP_Human0.90217718
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89152813
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85739452
98NCOR_22424771_ChIP-Seq_293T_Human0.85689247
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.81832738
100HTT_18923047_ChIP-ChIP_STHdh_Human0.80391485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.12096107
2MP0005671_abnormal_response_to3.70957075
3MP0000372_irregular_coat_pigmentation3.16956422
4MP0001835_abnormal_antigen_presentation2.79333982
5MP0003806_abnormal_nucleotide_metabolis2.69073509
6MP0008875_abnormal_xenobiotic_pharmacok2.48574589
7MP0002138_abnormal_hepatobiliary_system2.25815100
8MP0009785_altered_susceptibility_to2.25412682
9MP0003786_premature_aging2.24623783
10MP0001873_stomach_inflammation2.23252333
11MP0008872_abnormal_physiological_respon2.21335610
12MP0003195_calcinosis2.05809654
13MP0004147_increased_porphyrin_level2.00982220
14MP0005084_abnormal_gallbladder_morpholo1.97436926
15MP0009333_abnormal_splenocyte_physiolog1.92907471
16MP0003878_abnormal_ear_physiology1.92529020
17MP0005377_hearing/vestibular/ear_phenot1.92529020
18MP0008058_abnormal_DNA_repair1.89874504
19MP0005645_abnormal_hypothalamus_physiol1.88796763
20MP0002148_abnormal_hypersensitivity_rea1.85962398
21MP0006072_abnormal_retinal_apoptosis1.83309245
22MP0006036_abnormal_mitochondrial_physio1.83302690
23MP0001348_abnormal_lacrimal_gland1.79011558
24MP0002736_abnormal_nociception_after1.75798552
25MP0001529_abnormal_vocalization1.73001681
26MP0003718_maternal_effect1.68145548
27MP0003186_abnormal_redox_activity1.61692703
28MP0001919_abnormal_reproductive_system1.60785582
29MP0001800_abnormal_humoral_immune1.55775688
30MP0010094_abnormal_chromosome_stability1.55733339
31MP0002876_abnormal_thyroid_physiology1.52642970
32MP0002166_altered_tumor_susceptibility1.50486903
33MP0006082_CNS_inflammation1.48514487
34MP0002006_tumorigenesis1.47714058
35MP0006292_abnormal_olfactory_placode1.46002551
36MP0005000_abnormal_immune_tolerance1.45558013
37MP0001853_heart_inflammation1.45465418
38MP0005387_immune_system_phenotype1.43588465
39MP0001790_abnormal_immune_system1.43588465
40MP0004145_abnormal_muscle_electrophysio1.42791753
41MP0003763_abnormal_thymus_physiology1.40922669
42MP0008877_abnormal_DNA_methylation1.40838877
43MP0006054_spinal_hemorrhage1.40568136
44MP0005075_abnormal_melanosome_morpholog1.39671391
45MP0001905_abnormal_dopamine_level1.38343481
46MP0005253_abnormal_eye_physiology1.35613859
47MP0003693_abnormal_embryo_hatching1.34089516
48MP0000685_abnormal_immune_system1.32704504
49MP0002163_abnormal_gland_morphology1.32371828
50MP0001968_abnormal_touch/_nociception1.27602723
51MP0002723_abnormal_immune_serum1.27381642
52MP0003646_muscle_fatigue1.23533948
53MP0002277_abnormal_respiratory_mucosa1.22407946
54MP0003011_delayed_dark_adaptation1.21388192
55MP0006035_abnormal_mitochondrial_morpho1.21086369
56MP0003567_abnormal_fetal_cardiomyocyte1.21038764
57MP0002234_abnormal_pharynx_morphology1.15813464
58MP0002420_abnormal_adaptive_immunity1.14672417
59MP0005389_reproductive_system_phenotype1.12264374
60MP0005551_abnormal_eye_electrophysiolog1.11967502
61MP0004957_abnormal_blastocyst_morpholog1.08257155
62MP0005410_abnormal_fertilization1.08238849
63MP0001819_abnormal_immune_cell1.08193295
64MP0003866_abnormal_defecation1.07414257
65MP0005379_endocrine/exocrine_gland_phen1.03005093
66MP0005360_urolithiasis1.02220955
67MP0002405_respiratory_system_inflammati1.01939362
68MP0002452_abnormal_antigen_presenting1.01728817
69MP0001984_abnormal_olfaction0.98730204
70MP0005025_abnormal_response_to0.98187354
71MP0003283_abnormal_digestive_organ0.98132823
72MP0003137_abnormal_impulse_conducting0.95345209
73MP0002139_abnormal_hepatobiliary_system0.93674112
74MP0005408_hypopigmentation0.93163304
75MP0001845_abnormal_inflammatory_respons0.92725149
76MP0001764_abnormal_homeostasis0.91234328
77MP0005085_abnormal_gallbladder_physiolo0.90416835
78MP0004742_abnormal_vestibular_system0.89697400
79MP0000689_abnormal_spleen_morphology0.88186852
80MP0005332_abnormal_amino_acid0.87061948
81MP0002398_abnormal_bone_marrow0.86977235
82MP0004782_abnormal_surfactant_physiolog0.85430219
83MP0000716_abnormal_immune_system0.84794628
84MP0000465_gastrointestinal_hemorrhage0.84360825
85MP0005636_abnormal_mineral_homeostasis0.84029162
86MP0005395_other_phenotype0.83979589
87MP0008007_abnormal_cellular_replicative0.83880545
88MP0002938_white_spotting0.79130109
89MP0010386_abnormal_urinary_bladder0.78178965
90MP0005310_abnormal_salivary_gland0.76237918
91MP0001485_abnormal_pinna_reflex0.74094719
92MP0002429_abnormal_blood_cell0.73654173
93MP0001119_abnormal_female_reproductive0.73008491
94MP0002722_abnormal_immune_system0.72773011
95MP0001501_abnormal_sleep_pattern0.72109417
96MP0009745_abnormal_behavioral_response0.71703421
97MP0008995_early_reproductive_senescence0.71606669
98MP0003111_abnormal_nucleus_morphology0.70742007
99MP0004142_abnormal_muscle_tone0.70359111
100MP0004215_abnormal_myocardial_fiber0.69099054

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.61043545
2Mitochondrial inheritance (HP:0001427)4.38361943
3Abnormal mitochondria in muscle tissue (HP:0008316)4.27211843
4Acute encephalopathy (HP:0006846)4.24135018
5Increased CSF lactate (HP:0002490)4.13306597
6Increased hepatocellular lipid droplets (HP:0006565)3.97437160
7Hepatocellular necrosis (HP:0001404)3.87018108
8Progressive macrocephaly (HP:0004481)3.82754418
9Lipid accumulation in hepatocytes (HP:0006561)3.73548668
10Hepatic necrosis (HP:0002605)3.58344155
11IgG deficiency (HP:0004315)3.50068979
12Renal Fanconi syndrome (HP:0001994)3.34834057
13Cerebral edema (HP:0002181)3.21234995
14Increased intramyocellular lipid droplets (HP:0012240)3.19146446
15Increased serum lactate (HP:0002151)3.16323898
16Aplastic anemia (HP:0001915)3.12526434
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04810880
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04810880
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03551897
20Hypoproteinemia (HP:0003075)3.00673819
21Lactic acidosis (HP:0003128)2.79195177
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78093342
23Abnormality of T cell number (HP:0011839)2.77209173
24Chronic diarrhea (HP:0002028)2.76663595
25T lymphocytopenia (HP:0005403)2.65658373
26Increased muscle lipid content (HP:0009058)2.65464159
27Increased IgM level (HP:0003496)2.63247408
28Type I transferrin isoform profile (HP:0003642)2.62717390
29Stomatitis (HP:0010280)2.58343453
30Aplasia/hypoplasia of the uterus (HP:0008684)2.56935779
31Optic disc pallor (HP:0000543)2.55188776
32Exercise intolerance (HP:0003546)2.52300766
333-Methylglutaconic aciduria (HP:0003535)2.50186284
34Severe combined immunodeficiency (HP:0004430)2.48668691
35Methylmalonic acidemia (HP:0002912)2.43317576
36Lethargy (HP:0001254)2.37126502
37Methylmalonic aciduria (HP:0012120)2.36860979
38Abnormality of midbrain morphology (HP:0002418)2.35375000
39Molar tooth sign on MRI (HP:0002419)2.35375000
40Abnormality of T cells (HP:0002843)2.34887925
41Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34818637
42Exertional dyspnea (HP:0002875)2.33297604
43Elevated erythrocyte sedimentation rate (HP:0003565)2.30926065
44Respiratory failure (HP:0002878)2.30641109
45CNS demyelination (HP:0007305)2.30615623
46Oral leukoplakia (HP:0002745)2.26977982
47Type 2 muscle fiber atrophy (HP:0003554)2.25732402
48Pancreatic cysts (HP:0001737)2.24949400
49Hyperglycinemia (HP:0002154)2.22069721
50Abolished electroretinogram (ERG) (HP:0000550)2.21670738
51Pancytopenia (HP:0001876)2.18978528
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18155539
53Abnormal protein N-linked glycosylation (HP:0012347)2.18155539
54Abnormal protein glycosylation (HP:0012346)2.18155539
55Abnormal glycosylation (HP:0012345)2.18155539
56Microvesicular hepatic steatosis (HP:0001414)2.16361665
57Renal cortical cysts (HP:0000803)2.14364191
58Abnormality of placental membranes (HP:0011409)2.14131492
59Amniotic constriction ring (HP:0009775)2.14131492
60Generalized aminoaciduria (HP:0002909)2.13871172
61Reduced antithrombin III activity (HP:0001976)2.12068061
62Abnormality of eosinophils (HP:0001879)2.11399925
63Cerebral hypomyelination (HP:0006808)2.09093863
64Congenital stationary night blindness (HP:0007642)2.08616038
65Hypoplasia of the uterus (HP:0000013)2.08323957
66Leukodystrophy (HP:0002415)2.07130916
67Thyroiditis (HP:0100646)2.06929206
68Abnormality of serum amino acid levels (HP:0003112)2.05546413
69Abnormality of serine family amino acid metabolism (HP:0010894)2.05401432
70Abnormality of glycine metabolism (HP:0010895)2.05401432
71Increased serum pyruvate (HP:0003542)2.02010065
72Abnormality of alanine metabolism (HP:0010916)2.01159601
73Hyperalaninemia (HP:0003348)2.01159601
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01159601
75Abnormality of the renal cortex (HP:0011035)2.00448973
76Hyperglycinuria (HP:0003108)2.00111857
77Abnormality of the anterior horn cell (HP:0006802)1.99803657
78Degeneration of anterior horn cells (HP:0002398)1.99803657
79Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98179619
80Abnormality of the labia minora (HP:0012880)1.96287253
81Muscle fiber atrophy (HP:0100295)1.96098930
82Abnormality of the prostate (HP:0008775)1.94010520
83Glycosuria (HP:0003076)1.92657259
84Abnormality of urine glucose concentration (HP:0011016)1.92657259
85Respiratory difficulties (HP:0002880)1.92608929
86Abnormal albumin level (HP:0012116)1.92599041
87Hypoalbuminemia (HP:0003073)1.92599041
88Keratoconus (HP:0000563)1.88306231
89Increased corneal curvature (HP:0100692)1.88306231
90Abnormality of glycolysis (HP:0004366)1.86997023
91Abnormality of methionine metabolism (HP:0010901)1.85508202
92Abnormality of renal resorption (HP:0011038)1.85235586
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84900301
94True hermaphroditism (HP:0010459)1.84093096
95Combined immunodeficiency (HP:0005387)1.84060851
96Progressive microcephaly (HP:0000253)1.83938365
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80041960
98Dicarboxylic aciduria (HP:0003215)1.80041960
99Emotional lability (HP:0000712)1.79799301
100Pendular nystagmus (HP:0012043)1.78935253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.54992922
2TXK3.40657102
3BUB13.20332767
4ZAK3.05608391
5TLK12.68069801
6VRK12.61526628
7EIF2AK32.57207984
8MAP3K122.52108621
9BCKDK2.51066288
10EIF2AK12.39571322
11PBK2.24021453
12MST42.21218556
13TSSK62.10838346
14KDR2.10272800
15NUAK12.07110772
16MAP4K21.98663533
17TRIM281.85351454
18ADRBK21.81283860
19SRPK11.72497911
20PINK11.61539880
21NEK11.60423029
22INSRR1.59948184
23NME11.51385602
24PDK21.51352912
25GRK11.48717594
26TESK21.45189502
27PLK31.39634957
28BCR1.33034626
29WEE11.30984076
30TAF11.28016251
31MAPKAPK31.22962162
32BMPR1B1.20360511
33CSNK1G31.17414238
34STK161.16720944
35TIE11.11451080
36PLK21.09802431
37MAP4K11.09461669
38CCNB11.08189311
39STK391.07404835
40DAPK11.00808964
41FRK0.99652168
42CSNK1G20.97404411
43TNIK0.94019296
44TAOK30.93502836
45EIF2AK20.92245423
46CSNK1G10.90834413
47WNK30.90468491
48TEC0.89660333
49DYRK20.89110505
50OXSR10.88421251
51SCYL20.87479548
52ITK0.86710847
53WNK40.84017204
54CSNK1A1L0.82255760
55PLK40.78508309
56MYLK0.77977955
57MAP2K60.76654149
58IKBKB0.74580858
59RPS6KA50.71181870
60BRSK20.70449215
61PRKCQ0.68387380
62MAPK130.64129543
63FES0.63647359
64LIMK10.61597659
65PAK30.59354362
66SYK0.55982065
67GRK60.54116384
68TESK10.53831096
69MAPKAPK50.53197307
70PLK10.52059322
71PAK40.51940417
72KIT0.51850186
73ATR0.51584853
74ERBB30.46651499
75DAPK30.46420626
76GRK50.45645363
77AURKA0.45094957
78AURKB0.44643499
79PIK3CG0.44289703
80STK38L0.43736519
81LCK0.42271852
82CSNK2A10.41649125
83MKNK20.39395247
84CDC70.38335382
85PRKCE0.37185254
86CAMKK20.34734668
87CSNK2A20.34100034
88OBSCN0.34056048
89LYN0.32745146
90MKNK10.31296379
91IGF1R0.30565797
92CASK0.29625077
93PASK0.29527303
94PAK60.28950635
95PRKCG0.27654335
96CSNK1A10.26139337
97PRKCI0.26066380
98MAP3K110.25960152
99IKBKE0.25324328
100NLK0.24932090

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.52407753
2Oxidative phosphorylation_Homo sapiens_hsa001902.93744663
3Protein export_Homo sapiens_hsa030602.91737906
4Parkinsons disease_Homo sapiens_hsa050122.62599757
5Primary immunodeficiency_Homo sapiens_hsa053402.57251495
6RNA polymerase_Homo sapiens_hsa030202.40079765
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33828886
8Allograft rejection_Homo sapiens_hsa053302.16376535
9Autoimmune thyroid disease_Homo sapiens_hsa053202.06518888
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78913525
11Graft-versus-host disease_Homo sapiens_hsa053321.77737989
12One carbon pool by folate_Homo sapiens_hsa006701.71040189
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68197981
14Type I diabetes mellitus_Homo sapiens_hsa049401.66705183
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.66457298
16Asthma_Homo sapiens_hsa053101.65036793
17Non-homologous end-joining_Homo sapiens_hsa034501.64367278
18Systemic lupus erythematosus_Homo sapiens_hsa053221.64199209
19Alzheimers disease_Homo sapiens_hsa050101.58170352
20Huntingtons disease_Homo sapiens_hsa050161.57712690
21Homologous recombination_Homo sapiens_hsa034401.57569361
22Mismatch repair_Homo sapiens_hsa034301.42229081
23DNA replication_Homo sapiens_hsa030301.41649345
24Antigen processing and presentation_Homo sapiens_hsa046121.41037970
25Pyrimidine metabolism_Homo sapiens_hsa002401.38422290
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38078923
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37899284
28Basal transcription factors_Homo sapiens_hsa030221.37588751
29Propanoate metabolism_Homo sapiens_hsa006401.32278036
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30786482
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29001562
32Sulfur metabolism_Homo sapiens_hsa009201.28959475
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28891500
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27251539
35RNA degradation_Homo sapiens_hsa030181.22791276
36Nitrogen metabolism_Homo sapiens_hsa009101.20559390
37Base excision repair_Homo sapiens_hsa034101.17821238
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16916901
39Spliceosome_Homo sapiens_hsa030401.16236183
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14316950
41Selenocompound metabolism_Homo sapiens_hsa004501.13454336
42RNA transport_Homo sapiens_hsa030131.05329063
43Caffeine metabolism_Homo sapiens_hsa002321.05294079
44Fanconi anemia pathway_Homo sapiens_hsa034601.05139214
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04785928
46Phototransduction_Homo sapiens_hsa047441.03177474
47Rheumatoid arthritis_Homo sapiens_hsa053231.03071093
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.03017673
49Nucleotide excision repair_Homo sapiens_hsa034201.01284449
50Hematopoietic cell lineage_Homo sapiens_hsa046401.00372027
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00022875
52Peroxisome_Homo sapiens_hsa041460.99664966
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97356953
54Purine metabolism_Homo sapiens_hsa002300.95783797
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92362022
56Butanoate metabolism_Homo sapiens_hsa006500.88528292
57Glutathione metabolism_Homo sapiens_hsa004800.87612552
58Cardiac muscle contraction_Homo sapiens_hsa042600.87427956
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85858545
60Biosynthesis of amino acids_Homo sapiens_hsa012300.82273439
61Pyruvate metabolism_Homo sapiens_hsa006200.80688922
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79298313
63Linoleic acid metabolism_Homo sapiens_hsa005910.77369862
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75559901
65Ribosome_Homo sapiens_hsa030100.74086766
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.71323574
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.71183607
68Alcoholism_Homo sapiens_hsa050340.69796225
69Tryptophan metabolism_Homo sapiens_hsa003800.67842206
70Carbon metabolism_Homo sapiens_hsa012000.66441741
71Fatty acid elongation_Homo sapiens_hsa000620.65757816
72Metabolic pathways_Homo sapiens_hsa011000.61287304
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60972190
74Steroid biosynthesis_Homo sapiens_hsa001000.60936038
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56523561
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54241998
77Chemical carcinogenesis_Homo sapiens_hsa052040.53001252
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52389409
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50239423
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.50133064
81T cell receptor signaling pathway_Homo sapiens_hsa046600.47670884
82Viral myocarditis_Homo sapiens_hsa054160.46074779
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44251653
84Measles_Homo sapiens_hsa051620.42994005
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42555095
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42369175
87Vitamin B6 metabolism_Homo sapiens_hsa007500.41439249
88Folate biosynthesis_Homo sapiens_hsa007900.41098902
89Regulation of autophagy_Homo sapiens_hsa041400.40548024
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40274620
91Collecting duct acid secretion_Homo sapiens_hsa049660.39559735
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.39545788
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39368755
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.39166479
95N-Glycan biosynthesis_Homo sapiens_hsa005100.38989783
96Fatty acid metabolism_Homo sapiens_hsa012120.38539702
97Epstein-Barr virus infection_Homo sapiens_hsa051690.37107599
98Retinol metabolism_Homo sapiens_hsa008300.36331002
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35788382
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.33725349

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