ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.57503139
2	cytidine deamination (GO:0009972)	5.45567208
3	cytidine metabolic process (GO:0046087)	5.45567208
4	cytidine catabolic process (GO:0006216)	5.45567208
5	rRNA modification (GO:0000154)	5.28537553
6	piRNA metabolic process (GO:0034587)	5.12765041
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.82181075
8	rRNA methylation (GO:0031167)	4.74335611
9	regulation of isotype switching to IgG isotypes (GO:0048302)	4.66908133
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.53949297
11	DNA methylation involved in gamete generation (GO:0043046)	4.16328173
12	regulation of immunoglobulin secretion (GO:0051023)	3.87685077
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.74890466
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.74890466
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.74104979
16	positive regulation of isotype switching (GO:0045830)	3.74074780
17	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.72763128
18	proteasome assembly (GO:0043248)	3.71478598
19	centriole replication (GO:0007099)	3.62417529
20	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.55503272
21	positive regulation of DNA recombination (GO:0045911)	3.48572381
22	signal peptide processing (GO:0006465)	3.34758343
23	auditory receptor cell stereocilium organization (GO:0060088)	3.28203398
24	regulation of chronic inflammatory response (GO:0002676)	3.27133772
25	sperm motility (GO:0030317)	3.25582284
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.22697240
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20905578
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.18751792
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.18116938
30	ribosome biogenesis (GO:0042254)	3.15519977
31	regulation of cellular amino acid metabolic process (GO:0006521)	3.04025950
32	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.03710607
33	negative regulation of ligase activity (GO:0051352)	3.03710607
34	behavioral response to nicotine (GO:0035095)	3.01604139
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.00593735
36	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.98944783
37	isotype switching (GO:0045190)	2.98944783
38	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.98944783
39	viral mRNA export from host cell nucleus (GO:0046784)	2.98718822
40	ribosome assembly (GO:0042255)	2.97729327
41	tRNA processing (GO:0008033)	2.97114623
42	RNA destabilization (GO:0050779)	2.95481896
43	termination of RNA polymerase I transcription (GO:0006363)	2.94603340
44	pseudouridine synthesis (GO:0001522)	2.94081752
45	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93081070
46	GTP biosynthetic process (GO:0006183)	2.92516905
47	sperm-egg recognition (GO:0035036)	2.91733883
48	protein neddylation (GO:0045116)	2.91510745
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.87004635
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.85118881
51	L-fucose catabolic process (GO:0042355)	2.84806709
52	fucose catabolic process (GO:0019317)	2.84806709
53	L-fucose metabolic process (GO:0042354)	2.84806709
54	multicellular organism reproduction (GO:0032504)	2.84581529
55	fusion of sperm to egg plasma membrane (GO:0007342)	2.81744905
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.80299696
57	ATP synthesis coupled proton transport (GO:0015986)	2.80299696
58	tRNA metabolic process (GO:0006399)	2.79451134
59	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.74587221
60	folic acid-containing compound biosynthetic process (GO:0009396)	2.74114559
61	DNA double-strand break processing (GO:0000729)	2.71089691
62	rRNA processing (GO:0006364)	2.69886031
63	peptidyl-histidine modification (GO:0018202)	2.69756634
64	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.68541595
65	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.68541595
66	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.68541595
67	tRNA modification (GO:0006400)	2.68111728
68	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.66735904
69	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.66735904
70	centriole assembly (GO:0098534)	2.66411781
71	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.65746476
72	positive regulation of B cell mediated immunity (GO:0002714)	2.65275387
73	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.65275387
74	DNA integration (GO:0015074)	2.64803993
75	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.64788223
76	rRNA metabolic process (GO:0016072)	2.64577521
77	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.61138236
78	ncRNA metabolic process (GO:0034660)	2.60897377
79	UTP biosynthetic process (GO:0006228)	2.60041245
80	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59457731
81	termination of RNA polymerase III transcription (GO:0006386)	2.59457731
82	positive regulation of immunoglobulin production (GO:0002639)	2.59323537
83	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.58448800
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.58448800
85	regulation of isotype switching (GO:0045191)	2.57744282
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.56401589
87	protein K6-linked ubiquitination (GO:0085020)	2.54240431
88	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.53881302
89	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.53881302
90	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.53881302
91	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53838950
92	NADH dehydrogenase complex assembly (GO:0010257)	2.53838950
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53838950
94	protein complex biogenesis (GO:0070271)	2.53522974
95	water-soluble vitamin biosynthetic process (GO:0042364)	2.53382579
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.53253036
97	response to interferon-beta (GO:0035456)	2.53157216
98	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.52938115
99	tRNA methylation (GO:0030488)	2.49103991
100	ncRNA processing (GO:0034470)	2.49074629

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.88588036
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.24594318
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.55158180
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.31465116
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.71555507
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.38578673
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.23763398
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06733290
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.06400304
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.99063581
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86912294
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73470092
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.60686758
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.58744602
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.47847060
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44331534
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40784646
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.25974571
19	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.22760803
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.11234881
21	VDR_22108803_ChIP-Seq_LS180_Human	2.02235140
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00735556
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.98744227
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92504580
25	DCP1A_22483619_ChIP-Seq_HELA_Human	1.88735517
26	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.85089342
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84176205
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.83375368
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.79733905
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.77392732
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.75914482
32	E2F7_22180533_ChIP-Seq_HELA_Human	1.74161172
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.73678382
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.72703261
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.72393611
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.62303039
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.61886676
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61610746
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.61515040
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.57639309
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48918486
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46309257
43	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.42765119
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40658415
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40556640
46	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.36557531
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34668650
48	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.34437363
49	GATA3_26560356_Chip-Seq_TH2_Human	1.34254569
50	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.30324440
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29885716
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27840384
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27267121
54	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.27014782
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26638382
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.23630286
57	EWS_26573619_Chip-Seq_HEK293_Human	1.22361883
58	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.19957653
59	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.19549448
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19436299
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15849074
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15716912
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.14759474
64	MYB_26560356_Chip-Seq_TH2_Human	1.14694012
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.14358235
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13988589
67	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10141246
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10125153
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07051419
70	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.04549454
71	ELF5_23300383_ChIP-Seq_T47D_Human	1.03214315
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.02297374
73	FUS_26573619_Chip-Seq_HEK293_Human	0.99765489
74	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97962255
75	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.96399815
76	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96232650
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95264146
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95107412
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94803238
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94803238
81	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92702580
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92232918
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90224328
84	NCOR_22424771_ChIP-Seq_293T_Human	0.87905937
85	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87266146
86	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.86471479
87	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.85872818
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.85700302
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85033006
90	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.84256503
91	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.84214827
92	ER_23166858_ChIP-Seq_MCF-7_Human	0.83558080
93	AR_20517297_ChIP-Seq_VCAP_Human	0.82138065
94	GATA3_26560356_Chip-Seq_TH1_Human	0.80944470
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.80604928
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.80604928
97	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.80570470
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.80124571
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.79605442
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.79562604

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.58719381
2	MP0005671_abnormal_response_to	3.43329997
3	MP0002009_preneoplasia	3.33365884
4	MP0002166_altered_tumor_susceptibility	3.29554276
5	MP0001835_abnormal_antigen_presentation	3.23306391
6	MP0000685_abnormal_immune_system	3.00097557
7	MP0008877_abnormal_DNA_methylation	2.99189980
8	MP0002006_tumorigenesis	2.86822357
9	MP0005360_urolithiasis	2.78014507
10	MP0003693_abnormal_embryo_hatching	2.45813969
11	MP0002138_abnormal_hepatobiliary_system	2.24889191
12	MP0003786_premature_aging	2.18563727
13	MP0001348_abnormal_lacrimal_gland	2.12406300
14	MP0001873_stomach_inflammation	2.03420042
15	MP0002148_abnormal_hypersensitivity_rea	2.03391185
16	MP0010094_abnormal_chromosome_stability	1.98481087
17	MP0003718_maternal_effect	1.97452251
18	MP0009333_abnormal_splenocyte_physiolog	1.95885021
19	MP0006072_abnormal_retinal_apoptosis	1.92356103
20	MP0004957_abnormal_blastocyst_morpholog	1.78463114
21	MP0009697_abnormal_copulation	1.74143444
22	MP0001800_abnormal_humoral_immune	1.71116572
23	MP0005387_immune_system_phenotype	1.70556740
24	MP0001790_abnormal_immune_system	1.70556740
25	MP0005000_abnormal_immune_tolerance	1.70359502
26	MP0004147_increased_porphyrin_level	1.70156887
27	MP0003763_abnormal_thymus_physiology	1.69186879
28	MP0008058_abnormal_DNA_repair	1.67583517
29	MP0008875_abnormal_xenobiotic_pharmacok	1.61214021
30	MP0002877_abnormal_melanocyte_morpholog	1.57220937
31	MP0005377_hearing/vestibular/ear_phenot	1.57074661
32	MP0003878_abnormal_ear_physiology	1.57074661
33	MP0001853_heart_inflammation	1.56952515
34	MP0001929_abnormal_gametogenesis	1.54961769
35	MP0002163_abnormal_gland_morphology	1.54646241
36	MP0000372_irregular_coat_pigmentation	1.52388489
37	MP0008872_abnormal_physiological_respon	1.49944379
38	MP0005379_endocrine/exocrine_gland_phen	1.49688881
39	MP0001919_abnormal_reproductive_system	1.48233594
40	MP0002736_abnormal_nociception_after	1.47215806
41	MP0003436_decreased_susceptibility_to	1.36714463
42	MP0003698_abnormal_male_reproductive	1.33091725
43	MP0000538_abnormal_urinary_bladder	1.32510579
44	MP0002723_abnormal_immune_serum	1.30742440
45	MP0003186_abnormal_redox_activity	1.30284768
46	MP0002653_abnormal_ependyma_morphology	1.28079481
47	MP0005551_abnormal_eye_electrophysiolog	1.22057713
48	MP0003077_abnormal_cell_cycle	1.21244717
49	MP0000689_abnormal_spleen_morphology	1.20110241
50	MP0009785_altered_susceptibility_to	1.19607248
51	MP0002398_abnormal_bone_marrow	1.19547445
52	MP0005253_abnormal_eye_physiology	1.18818913
53	MP0002452_abnormal_antigen_presenting	1.18171907
54	MP0004742_abnormal_vestibular_system	1.16563018
55	MP0003111_abnormal_nucleus_morphology	1.16168472
56	MP0001968_abnormal_touch/_nociception	1.15585847
57	MP0002420_abnormal_adaptive_immunity	1.14956506
58	MP0005389_reproductive_system_phenotype	1.14130921
59	MP0008057_abnormal_DNA_replication	1.12724657
60	MP0002210_abnormal_sex_determination	1.12387948
61	MP0002876_abnormal_thyroid_physiology	1.10968033
62	MP0000703_abnormal_thymus_morphology	1.10055218
63	MP0004264_abnormal_extraembryonic_tissu	1.09865900
64	MP0005310_abnormal_salivary_gland	1.09213384
65	MP0001819_abnormal_immune_cell	1.08509097
66	MP0005332_abnormal_amino_acid	1.08309947
67	MP0003806_abnormal_nucleotide_metabolis	1.08251998
68	MP0002722_abnormal_immune_system	0.99016443
69	MP0002405_respiratory_system_inflammati	0.97138779
70	MP0000653_abnormal_sex_gland	0.96989899
71	MP0001145_abnormal_male_reproductive	0.96638444
72	MP0002019_abnormal_tumor_incidence	0.95160460
73	MP0001845_abnormal_inflammatory_respons	0.95008251
74	MP0006292_abnormal_olfactory_placode	0.94823500
75	MP0003045_fibrosis	0.94753726
76	MP0000716_abnormal_immune_system	0.93334615
77	MP0001502_abnormal_circadian_rhythm	0.91610297
78	MP0002160_abnormal_reproductive_system	0.91040956
79	MP0000490_abnormal_crypts_of	0.90864400
80	MP0003866_abnormal_defecation	0.90317895
81	MP0006036_abnormal_mitochondrial_physio	0.89812195
82	MP0004145_abnormal_muscle_electrophysio	0.88220403
83	MP0001986_abnormal_taste_sensitivity	0.85406655
84	MP0005075_abnormal_melanosome_morpholog	0.84352295
85	MP0001984_abnormal_olfaction	0.84296213
86	MP0010155_abnormal_intestine_physiology	0.84279974
87	MP0004142_abnormal_muscle_tone	0.84239665
88	MP0001905_abnormal_dopamine_level	0.83501458
89	MP0002429_abnormal_blood_cell	0.83069195
90	MP0008932_abnormal_embryonic_tissue	0.81564429
91	MP0000604_amyloidosis	0.81201283
92	MP0006082_CNS_inflammation	0.79800899
93	MP0005645_abnormal_hypothalamus_physiol	0.77504813
94	MP0003646_muscle_fatigue	0.77070129
95	MP0005084_abnormal_gallbladder_morpholo	0.76481471
96	MP0002933_joint_inflammation	0.76392197
97	MP0008007_abnormal_cellular_replicative	0.74485190
98	MP0002161_abnormal_fertility/fecundity	0.72694906
99	MP0008995_early_reproductive_senescence	0.72135027
100	MP0006276_abnormal_autonomic_nervous	0.70493542

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.29983955
2	Stomatitis (HP:0010280)	4.00800113
3	Azoospermia (HP:0000027)	3.87727362
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.82959106
5	Absent/shortened dynein arms (HP:0200106)	3.82959106
6	Acute necrotizing encephalopathy (HP:0006965)	3.62046766
7	Abnormal spermatogenesis (HP:0008669)	3.52444984
8	Acute encephalopathy (HP:0006846)	3.38381710
9	Mitochondrial inheritance (HP:0001427)	3.21733998
10	Increased CSF lactate (HP:0002490)	3.16288204
11	Progressive macrocephaly (HP:0004481)	3.13600979
12	Pendular nystagmus (HP:0012043)	3.12852269
13	Abnormality of the pons (HP:0007361)	3.10243476
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.08421386
15	Increased hepatocellular lipid droplets (HP:0006565)	3.07519071
16	Renal Fanconi syndrome (HP:0001994)	3.04637678
17	Cerebral edema (HP:0002181)	2.96001326
18	Pancreatic cysts (HP:0001737)	2.95702990
19	Lipid accumulation in hepatocytes (HP:0006561)	2.91281629
20	Severe combined immunodeficiency (HP:0004430)	2.89757237
21	Increased IgM level (HP:0003496)	2.84354378
22	Pancreatic fibrosis (HP:0100732)	2.84340641
23	Cutaneous melanoma (HP:0012056)	2.82285481
24	Hypoplasia of the pons (HP:0012110)	2.80186583
25	Prostate neoplasm (HP:0100787)	2.79139660
26	Hypoproteinemia (HP:0003075)	2.70998150
27	Abnormality of T cell physiology (HP:0011840)	2.68510219
28	Nephronophthisis (HP:0000090)	2.65159259
29	Bile duct proliferation (HP:0001408)	2.62237526
30	Abnormal biliary tract physiology (HP:0012439)	2.62237526
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.61862729
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.61862729
33	Abnormality of the prostate (HP:0008775)	2.59043827
34	Panhypogammaglobulinemia (HP:0003139)	2.58998427
35	Abnormal ciliary motility (HP:0012262)	2.57787313
36	Supernumerary spleens (HP:0009799)	2.55695154
37	Abnormality of T cells (HP:0002843)	2.54779178
38	Aplastic anemia (HP:0001915)	2.53333208
39	Hepatocellular necrosis (HP:0001404)	2.53174553
40	Combined immunodeficiency (HP:0005387)	2.52569632
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51532753
42	Thyroiditis (HP:0100646)	2.47751608
43	Squamous cell carcinoma (HP:0002860)	2.47722499
44	Hypothermia (HP:0002045)	2.46976312
45	3-Methylglutaconic aciduria (HP:0003535)	2.46629734
46	Attenuation of retinal blood vessels (HP:0007843)	2.44441128
47	Testicular atrophy (HP:0000029)	2.44068497
48	Pancytopenia (HP:0001876)	2.43381896
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.42687229
50	True hermaphroditism (HP:0010459)	2.41852481
51	IgA deficiency (HP:0002720)	2.39370538
52	Elevated erythrocyte sedimentation rate (HP:0003565)	2.29859092
53	Hepatic necrosis (HP:0002605)	2.29437199
54	Abnormality of the renal collecting system (HP:0004742)	2.29248165
55	Increased serum lactate (HP:0002151)	2.28933742
56	Type 2 muscle fiber atrophy (HP:0003554)	2.27813225
57	Abnormality of the renal medulla (HP:0100957)	2.27358169
58	Duplicated collecting system (HP:0000081)	2.26236979
59	Abnormality of DNA repair (HP:0003254)	2.24025994
60	Hypoplasia of the thymus (HP:0000778)	2.22670056
61	Optic disc pallor (HP:0000543)	2.21769237
62	Chorioretinal atrophy (HP:0000533)	2.19760528
63	Molar tooth sign on MRI (HP:0002419)	2.18397627
64	Abnormality of midbrain morphology (HP:0002418)	2.18397627
65	Chronic diarrhea (HP:0002028)	2.17071093
66	Abnormality of the renal cortex (HP:0011035)	2.10799320
67	Hyperglycinuria (HP:0003108)	2.10051679
68	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.09610071
69	Abnormality of T cell number (HP:0011839)	2.09559004
70	Tongue fasciculations (HP:0001308)	2.09037286
71	T lymphocytopenia (HP:0005403)	2.08065011
72	Chronic hepatic failure (HP:0100626)	2.03337667
73	Type II lissencephaly (HP:0007260)	2.02617585
74	Lactic acidosis (HP:0003128)	2.02036632
75	Congenital stationary night blindness (HP:0007642)	2.01797094
76	Keratoconus (HP:0000563)	2.01213488
77	Increased corneal curvature (HP:0100692)	2.01213488
78	Tubular atrophy (HP:0000092)	2.01164176
79	Muscle fiber atrophy (HP:0100295)	2.01031954
80	Oral leukoplakia (HP:0002745)	2.00098334
81	Gonadotropin excess (HP:0000837)	1.99064438
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.98818395
83	Infertility (HP:0000789)	1.97247458
84	Congenital, generalized hypertrichosis (HP:0004540)	1.95762725
85	Abolished electroretinogram (ERG) (HP:0000550)	1.95701491
86	Lethargy (HP:0001254)	1.89932687
87	Methylmalonic acidemia (HP:0002912)	1.88547632
88	Microvesicular hepatic steatosis (HP:0001414)	1.88168578
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86402561
90	Methylmalonic aciduria (HP:0012120)	1.85592602
91	Abnormality of the labia minora (HP:0012880)	1.84196379
92	Exertional dyspnea (HP:0002875)	1.83488677
93	Large for gestational age (HP:0001520)	1.82773895
94	Abnormal drinking behavior (HP:0030082)	1.82604187
95	Polydipsia (HP:0001959)	1.82604187
96	Abnormality of the anterior horn cell (HP:0006802)	1.81974540
97	Degeneration of anterior horn cells (HP:0002398)	1.81974540
98	Abnormality of glycine metabolism (HP:0010895)	1.80605226
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80605226
100	Decreased central vision (HP:0007663)	1.80302644

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.53753873
2	VRK2	3.44475867
3	BUB1	3.14719934
4	TLK1	3.13407100
5	ACVR1B	3.03049065
6	PLK4	2.98134871
7	FRK	2.81431951
8	VRK1	2.80753057
9	EIF2AK3	2.72641989
10	TXK	2.59816830
11	MST4	2.51030778
12	SRPK1	2.50917234
13	TSSK6	2.37894978
14	PBK	2.19859309
15	MAPKAPK3	2.04495220
16	STK16	1.89303885
17	NUAK1	1.83497948
18	TAF1	1.78941214
19	EIF2AK1	1.75822364
20	TAOK3	1.58693655
21	PLK3	1.56392096
22	WNK4	1.52779387
23	TEC	1.51660038
24	PLK2	1.47324749
25	PINK1	1.39094096
26	ITK	1.37223975
27	GRK1	1.30982648
28	BRD4	1.28804263
29	ADRBK2	1.22904490
30	STK39	1.18876590
31	IKBKB	1.17355751
32	TNK2	1.16569177
33	TRIM28	1.15620996
34	MAP4K2	1.11364173
35	FER	1.10627603
36	INSRR	1.00734825
37	PDK2	0.99921330
38	NME1	0.98474967
39	ALK	0.96823937
40	ERBB3	0.94905711
41	CSNK1G3	0.91023608
42	BMPR1B	0.90736401
43	AURKA	0.90138227
44	PHKG2	0.85196412
45	PHKG1	0.85196412
46	CDK7	0.83273155
47	RPS6KA5	0.82392371
48	PLK1	0.82068410
49	MAP4K1	0.81490288
50	DAPK1	0.76722749
51	TTK	0.76056886
52	NLK	0.72027768
53	CSNK1G1	0.70291599
54	TIE1	0.68899021
55	CDC7	0.68573911
56	MAP2K6	0.68306603
57	MKNK2	0.68306205
58	NEK1	0.67581576
59	RPS6KA4	0.66133066
60	PIK3CG	0.64582862
61	PRKCQ	0.62950617
62	DYRK2	0.62464379
63	ATR	0.61348328
64	OXSR1	0.61095164
65	BMPR2	0.61022026
66	MAPK13	0.60054065
67	KDR	0.60035824
68	NEK2	0.57905842
69	BCKDK	0.56968136
70	SCYL2	0.54661510
71	CSNK1G2	0.51683642
72	SYK	0.50995129
73	EPHA3	0.48993639
74	EIF2AK2	0.48182564
75	PIM1	0.47984979
76	CHEK2	0.47188287
77	MKNK1	0.46996580
78	CHEK1	0.46934039
79	CSNK1A1L	0.45963341
80	AURKB	0.45843064
81	CDK9	0.45511856
82	CSNK2A2	0.43213019
83	PRKCI	0.41440352
84	PRKG2	0.39428907
85	WEE1	0.38620374
86	MAP3K11	0.37296476
87	MAP3K4	0.36604005
88	MAP3K5	0.34221483
89	WNK3	0.33912382
90	CSNK2A1	0.32727105
91	MELK	0.32068010
92	CCNB1	0.31770072
93	JAK3	0.31003823
94	BRSK2	0.30372545
95	GRK6	0.29731754
96	TESK2	0.29652271
97	CDK8	0.29083785
98	KIT	0.26739235
99	IRAK1	0.25750963
100	CSNK1A1	0.24110302

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.23469630
2	RNA polymerase_Homo sapiens_hsa03020	3.24359975
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.00696707
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.73320201
5	Allograft rejection_Homo sapiens_hsa05330	2.49222648
6	Basal transcription factors_Homo sapiens_hsa03022	2.47387897
7	Protein export_Homo sapiens_hsa03060	2.44233234
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33142879
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.30497548
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.28610011
11	RNA transport_Homo sapiens_hsa03013	2.21402901
12	Asthma_Homo sapiens_hsa05310	2.13002585
13	Parkinsons disease_Homo sapiens_hsa05012	2.12914784
14	Homologous recombination_Homo sapiens_hsa03440	2.01060935
15	One carbon pool by folate_Homo sapiens_hsa00670	1.99020349
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.97281986
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96441154
18	RNA degradation_Homo sapiens_hsa03018	1.91832864
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91762474
20	DNA replication_Homo sapiens_hsa03030	1.90178605
21	Ribosome_Homo sapiens_hsa03010	1.80699336
22	Sulfur relay system_Homo sapiens_hsa04122	1.77292100
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.70619402
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.65183662
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63537411
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.63439117
27	Mismatch repair_Homo sapiens_hsa03430	1.63330676
28	Spliceosome_Homo sapiens_hsa03040	1.60804528
29	Huntingtons disease_Homo sapiens_hsa05016	1.56929864
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.45308077
31	Propanoate metabolism_Homo sapiens_hsa00640	1.43069119
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.36676708
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33750396
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.28867902
35	Base excision repair_Homo sapiens_hsa03410	1.26586490
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.26132216
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22414385
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22391430
39	Phototransduction_Homo sapiens_hsa04744	1.21586503
40	Purine metabolism_Homo sapiens_hsa00230	1.13486470
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13350927
42	Alzheimers disease_Homo sapiens_hsa05010	1.12991294
43	Caffeine metabolism_Homo sapiens_hsa00232	1.06914089
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05219958
45	Folate biosynthesis_Homo sapiens_hsa00790	1.02023155
46	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.01681933
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00268885
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99633446
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99144602
50	Peroxisome_Homo sapiens_hsa04146	0.96278246
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94363850
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92335372
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88702706
54	Butanoate metabolism_Homo sapiens_hsa00650	0.86552327
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.86467919
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.83912375
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.81556807
58	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75109444
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73869655
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.71079912
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.70830666
62	Regulation of autophagy_Homo sapiens_hsa04140	0.70776741
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69367429
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65777116
65	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.64579831
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63802454
67	p53 signaling pathway_Homo sapiens_hsa04115	0.62970934
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62509992
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59179601
70	Olfactory transduction_Homo sapiens_hsa04740	0.58351170
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57460502
72	Mineral absorption_Homo sapiens_hsa04978	0.56629893
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.56033621
74	Measles_Homo sapiens_hsa05162	0.55569137
75	Metabolic pathways_Homo sapiens_hsa01100	0.55194110
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.53278505
77	Sulfur metabolism_Homo sapiens_hsa00920	0.53146704
78	Glutathione metabolism_Homo sapiens_hsa00480	0.52139016
79	Cell cycle_Homo sapiens_hsa04110	0.51450401
80	Alcoholism_Homo sapiens_hsa05034	0.44293925
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43518377
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43075138
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41204177
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36820141
85	Fatty acid degradation_Homo sapiens_hsa00071	0.34676547
86	Carbon metabolism_Homo sapiens_hsa01200	0.32589523
87	Viral carcinogenesis_Homo sapiens_hsa05203	0.31288051
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.30614159
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.28460531
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28140684
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27016090
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26534646
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26314199
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.25131708
95	Oocyte meiosis_Homo sapiens_hsa04114	0.25083395
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23421033
97	Fatty acid elongation_Homo sapiens_hsa00062	0.22701227
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.21942723
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.21793342
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.21354264

TPI1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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