TPI1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.57573423
2positive regulation of interleukin-17 production (GO:0032740)4.44714257
3fucose catabolic process (GO:0019317)3.99389432
4L-fucose metabolic process (GO:0042354)3.99389432
5L-fucose catabolic process (GO:0042355)3.99389432
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.97910655
7positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.92322876
8positive regulation of natural killer cell mediated immunity (GO:0002717)3.86640749
9water-soluble vitamin biosynthetic process (GO:0042364)3.84262858
10positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71580561
11positive regulation of cell killing (GO:0031343)3.58316604
12DNA catabolic process, exonucleolytic (GO:0000738)3.56057003
13regulation of cellular amino acid metabolic process (GO:0006521)3.55527424
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52518919
15signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49017981
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49017981
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49017981
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45423606
19regulation of isotype switching to IgG isotypes (GO:0048302)3.44562213
20cullin deneddylation (GO:0010388)3.42863614
21regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42711476
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41746761
23signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41746761
24pseudouridine synthesis (GO:0001522)3.40280193
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.37414509
26regulation of T cell mediated cytotoxicity (GO:0001914)3.36799023
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.35883416
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31465676
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.31465676
30protein deneddylation (GO:0000338)3.30824163
31signal transduction involved in cell cycle checkpoint (GO:0072395)3.27450758
32lactate metabolic process (GO:0006089)3.26669960
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23424253
34regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.21857101
35positive regulation of natural killer cell differentiation (GO:0032825)3.20288941
36DNA double-strand break processing (GO:0000729)3.20032038
37axoneme assembly (GO:0035082)3.17416802
38proteasome assembly (GO:0043248)3.16948451
39regulation of cell killing (GO:0031341)3.16107024
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13507300
41negative regulation of ligase activity (GO:0051352)3.13507300
42protein complex biogenesis (GO:0070271)3.12839898
43DNA ligation (GO:0006266)3.09399037
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09173578
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07393709
46ATP synthesis coupled proton transport (GO:0015986)3.07393709
47respiratory chain complex IV assembly (GO:0008535)3.04190730
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00142274
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00142274
50peptidyl-histidine modification (GO:0018202)2.99966685
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99387516
52mitochondrial respiratory chain complex I assembly (GO:0032981)2.96771573
53NADH dehydrogenase complex assembly (GO:0010257)2.96771573
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96771573
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95417255
56regulation of natural killer cell mediated immunity (GO:0002715)2.95417255
57positive regulation of defense response to virus by host (GO:0002230)2.93701141
58folic acid-containing compound biosynthetic process (GO:0009396)2.93012630
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89902228
60mitochondrial respiratory chain complex assembly (GO:0033108)2.89184182
61maturation of 5.8S rRNA (GO:0000460)2.87729517
62positive regulation of T-helper 1 type immune response (GO:0002827)2.85271720
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83358428
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81244857
65preassembly of GPI anchor in ER membrane (GO:0016254)2.80932904
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79424382
67regulation of interleukin-17 production (GO:0032660)2.79253436
68protein neddylation (GO:0045116)2.78923390
69protein K6-linked ubiquitination (GO:0085020)2.77720741
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76941661
71regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.76531583
72regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.73070085
73DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72343002
74tRNA processing (GO:0008033)2.70777369
75positive regulation of ligase activity (GO:0051351)2.70325783
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70106579
77negative regulation of neurological system process (GO:0031645)2.69163079
78tRNA modification (GO:0006400)2.68347373
79double-strand break repair via nonhomologous end joining (GO:0006303)2.67603284
80non-recombinational repair (GO:0000726)2.67603284
81cellular response to interleukin-15 (GO:0071350)2.65594281
82chaperone-mediated protein transport (GO:0072321)2.64901340
83positive regulation of cell cycle arrest (GO:0071158)2.64738108
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.64505299
85isotype switching (GO:0045190)2.64505299
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.64505299
87indolalkylamine metabolic process (GO:0006586)2.64188996
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62029208
89establishment of integrated proviral latency (GO:0075713)2.61871232
90piRNA metabolic process (GO:0034587)2.61331985
91tRNA metabolic process (GO:0006399)2.60901427
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60502335
93mismatch repair (GO:0006298)2.58984575
94positive regulation of lymphocyte mediated immunity (GO:0002708)2.58640127
95cytochrome complex assembly (GO:0017004)2.57744890
96antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55074381
97protein-cofactor linkage (GO:0018065)2.52771213
98positive regulation of DNA recombination (GO:0045911)2.52728876
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52063756
100protein targeting to mitochondrion (GO:0006626)2.51355097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.52368789
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24018591
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.80200680
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.38634714
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17030600
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07781479
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91298432
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88339325
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75363586
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.65561317
11VDR_23849224_ChIP-Seq_CD4+_Human2.55657094
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53083773
13ZNF274_21170338_ChIP-Seq_K562_Hela2.51172236
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35215469
15* VDR_22108803_ChIP-Seq_LS180_Human2.35074878
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.32656494
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27166146
18ELK1_19687146_ChIP-ChIP_HELA_Human2.19901841
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.15838415
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.04975712
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.02864234
22FOXP3_21729870_ChIP-Seq_TREG_Human2.01169929
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97503621
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94016353
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87453766
26IGF1R_20145208_ChIP-Seq_DFB_Human1.79272556
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76422676
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70006221
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.62461615
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60905609
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60584531
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57074123
33IRF1_19129219_ChIP-ChIP_H3396_Human1.56935197
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56824064
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56018200
36MYC_18940864_ChIP-ChIP_HL60_Human1.55826388
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54585219
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.53023240
39EWS_26573619_Chip-Seq_HEK293_Human1.49971446
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49535646
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47867684
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47339508
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47277765
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47213200
45ER_23166858_ChIP-Seq_MCF-7_Human1.46324306
46TP53_22573176_ChIP-Seq_HFKS_Human1.44232920
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41970739
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40874066
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.40673986
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34469284
51GATA3_26560356_Chip-Seq_TH2_Human1.33035249
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27010200
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26949748
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22307205
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.22115189
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.20809404
57* P300_19829295_ChIP-Seq_ESCs_Human1.20104647
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18073897
59GABP_19822575_ChIP-Seq_HepG2_Human1.15865349
60HOXB7_26014856_ChIP-Seq_BT474_Human1.15797542
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15340375
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14706492
63MYB_26560356_Chip-Seq_TH2_Human1.13720731
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12769387
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.12769387
66FUS_26573619_Chip-Seq_HEK293_Human1.12714147
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09526350
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.07508889
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07467908
70NANOG_19829295_ChIP-Seq_ESCs_Human1.06437816
71SOX2_19829295_ChIP-Seq_ESCs_Human1.06437816
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05588176
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05463267
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.05225203
75TAF15_26573619_Chip-Seq_HEK293_Human1.04740384
76AR_20517297_ChIP-Seq_VCAP_Human1.04276756
77CIITA_25753668_ChIP-Seq_RAJI_Human1.02322089
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01773506
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01390857
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97264338
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97022141
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96218010
83MYC_18555785_ChIP-Seq_MESCs_Mouse0.96014022
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95971224
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95674910
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93445297
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93351929
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93146901
89* NCOR_22424771_ChIP-Seq_293T_Human0.92340362
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90965573
91TCF4_22108803_ChIP-Seq_LS180_Human0.90328458
92DCP1A_22483619_ChIP-Seq_HELA_Human0.88863286
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88349178
94CBP_20019798_ChIP-Seq_JUKART_Human0.88349178
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87767861
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87096259
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.86996684
98RBPJ_21746931_ChIP-Seq_IB4_Human0.86352880
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86232181
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.86206173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.39485032
2MP0001835_abnormal_antigen_presentation3.21773236
3MP0003786_premature_aging2.84216623
4MP0005671_abnormal_response_to2.78129052
5MP0008877_abnormal_DNA_methylation2.60714828
6MP0003011_delayed_dark_adaptation2.57524810
7MP0001501_abnormal_sleep_pattern2.37097298
8MP0005084_abnormal_gallbladder_morpholo2.26218292
9MP0009333_abnormal_splenocyte_physiolog2.22785842
10MP0008058_abnormal_DNA_repair2.21545437
11MP0001984_abnormal_olfaction2.14343682
12MP0002876_abnormal_thyroid_physiology2.10288008
13MP0009785_altered_susceptibility_to2.07378222
14MP0010386_abnormal_urinary_bladder1.99437588
15MP0001790_abnormal_immune_system1.97678894
16MP0005387_immune_system_phenotype1.97678894
17MP0008872_abnormal_physiological_respon1.95522623
18MP0002006_tumorigenesis1.94118429
19MP0006072_abnormal_retinal_apoptosis1.92547079
20MP0005085_abnormal_gallbladder_physiolo1.88226053
21MP0003195_calcinosis1.86879423
22MP0008875_abnormal_xenobiotic_pharmacok1.86428131
23MP0000685_abnormal_immune_system1.83472308
24MP0002138_abnormal_hepatobiliary_system1.82390117
25MP0005310_abnormal_salivary_gland1.80561429
26MP0006036_abnormal_mitochondrial_physio1.78108588
27MP0001873_stomach_inflammation1.74755342
28MP0005075_abnormal_melanosome_morpholog1.73989503
29MP0000372_irregular_coat_pigmentation1.72410846
30MP0005551_abnormal_eye_electrophysiolog1.71770561
31MP0003646_muscle_fatigue1.70653828
32MP0005083_abnormal_biliary_tract1.67004167
33MP0004145_abnormal_muscle_electrophysio1.65735534
34MP0002166_altered_tumor_susceptibility1.63152223
35MP0005000_abnormal_immune_tolerance1.53378071
36MP0002693_abnormal_pancreas_physiology1.52258886
37MP0001764_abnormal_homeostasis1.51117234
38MP0005645_abnormal_hypothalamus_physiol1.50819689
39MP0006035_abnormal_mitochondrial_morpho1.47255259
40MP0005379_endocrine/exocrine_gland_phen1.37123255
41MP0005253_abnormal_eye_physiology1.36904336
42MP0001968_abnormal_touch/_nociception1.36480997
43MP0001800_abnormal_humoral_immune1.34597370
44MP0002148_abnormal_hypersensitivity_rea1.34216651
45MP0010094_abnormal_chromosome_stability1.31759131
46MP0001348_abnormal_lacrimal_gland1.30405897
47MP0001853_heart_inflammation1.29970056
48MP0000427_abnormal_hair_cycle1.29342578
49MP0003693_abnormal_embryo_hatching1.15701224
50MP0008775_abnormal_heart_ventricle1.14044489
51MP0002723_abnormal_immune_serum1.13283360
52MP0001502_abnormal_circadian_rhythm1.12055572
53MP0005646_abnormal_pituitary_gland1.10952387
54MP0002837_dystrophic_cardiac_calcinosis1.10766432
55MP0003806_abnormal_nucleotide_metabolis1.10747626
56MP0002736_abnormal_nociception_after1.09847998
57MP0002420_abnormal_adaptive_immunity1.09534220
58MP0003866_abnormal_defecation1.09426518
59MP0004215_abnormal_myocardial_fiber1.06400455
60MP0004147_increased_porphyrin_level1.06396487
61MP0002638_abnormal_pupillary_reflex1.05734227
62MP0001819_abnormal_immune_cell1.04107240
63MP0006082_CNS_inflammation1.04047531
64MP0001845_abnormal_inflammatory_respons1.01195700
65MP0000689_abnormal_spleen_morphology0.97926204
66MP0003186_abnormal_redox_activity0.97911597
67MP0002452_abnormal_antigen_presenting0.97900794
68MP0000538_abnormal_urinary_bladder0.96923095
69MP0008007_abnormal_cellular_replicative0.94354007
70MP0001986_abnormal_taste_sensitivity0.93076813
71MP0003763_abnormal_thymus_physiology0.91479102
72MP0003950_abnormal_plasma_membrane0.91254904
73MP0002398_abnormal_bone_marrow0.90924666
74MP0005365_abnormal_bile_salt0.90699939
75MP0001905_abnormal_dopamine_level0.89774405
76MP0004957_abnormal_blastocyst_morpholog0.88185636
77MP0002272_abnormal_nervous_system0.87918789
78MP0009046_muscle_twitch0.87573659
79MP0001881_abnormal_mammary_gland0.87290575
80MP0000465_gastrointestinal_hemorrhage0.85764437
81MP0005025_abnormal_response_to0.85151855
82MP0009745_abnormal_behavioral_response0.84844858
83MP0003718_maternal_effect0.82657879
84MP0004142_abnormal_muscle_tone0.82455922
85MP0000716_abnormal_immune_system0.82027630
86MP0005389_reproductive_system_phenotype0.78933461
87MP0005167_abnormal_blood-brain_barrier0.78184240
88MP0002163_abnormal_gland_morphology0.77346611
89MP0004885_abnormal_endolymph0.75478412
90MP0001661_extended_life_span0.74827257
91MP0002429_abnormal_blood_cell0.72119674
92MP0005332_abnormal_amino_acid0.71159575
93MP0008469_abnormal_protein_level0.70538070
94MP0002277_abnormal_respiratory_mucosa0.70509604
95MP0002722_abnormal_immune_system0.70287301
96MP0010155_abnormal_intestine_physiology0.70267956
97MP0003137_abnormal_impulse_conducting0.69863706
98MP0001765_abnormal_ion_homeostasis0.69752999
99MP0003567_abnormal_fetal_cardiomyocyte0.69498205
100MP0008995_early_reproductive_senescence0.69020783

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)3.92964191
2Retrobulbar optic neuritis (HP:0100654)3.92964191
3Acute necrotizing encephalopathy (HP:0006965)3.72469275
4Mitochondrial inheritance (HP:0001427)3.50514158
5Increased CSF lactate (HP:0002490)3.43863118
6Abnormal mitochondria in muscle tissue (HP:0008316)3.29892322
7Progressive macrocephaly (HP:0004481)3.21951986
8Orchitis (HP:0100796)3.18830896
9Hepatocellular necrosis (HP:0001404)3.18184976
10Acute encephalopathy (HP:0006846)3.17517180
113-Methylglutaconic aciduria (HP:0003535)3.14624529
12IgG deficiency (HP:0004315)2.99098454
13Lipid accumulation in hepatocytes (HP:0006561)2.93749183
14Keratoconjunctivitis (HP:0001096)2.93743921
15Cerebral edema (HP:0002181)2.91302511
16Myositis (HP:0100614)2.90106940
17Abnormality of the renal cortex (HP:0011035)2.88883889
18Hepatic necrosis (HP:0002605)2.87706353
19Keratoconjunctivitis sicca (HP:0001097)2.84702529
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75992908
21Increased hepatocellular lipid droplets (HP:0006565)2.71440836
22Renal cortical cysts (HP:0000803)2.69351804
23Stomatitis (HP:0010280)2.67401089
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66534735
25Abnormality of the labia minora (HP:0012880)2.65625687
26Increased serum lactate (HP:0002151)2.63547566
27Progressive inability to walk (HP:0002505)2.59106099
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57799948
29Congenital stationary night blindness (HP:0007642)2.57332976
30Thyroiditis (HP:0100646)2.54545535
31Optic disc pallor (HP:0000543)2.53723158
32Severe combined immunodeficiency (HP:0004430)2.46288425
33Elevated erythrocyte sedimentation rate (HP:0003565)2.45624202
34Methylmalonic acidemia (HP:0002912)2.42742484
35Abolished electroretinogram (ERG) (HP:0000550)2.38501439
36Chronic diarrhea (HP:0002028)2.37342727
37Pancreatic cysts (HP:0001737)2.37311568
38Gaze-evoked nystagmus (HP:0000640)2.36883238
39Hypothermia (HP:0002045)2.31761168
40Constricted visual fields (HP:0001133)2.31108517
41Abnormality of methionine metabolism (HP:0010901)2.26296538
42Hypoproteinemia (HP:0003075)2.26172017
43Pulmonary infiltrates (HP:0002113)2.22577308
44Abnormality of the anterior horn cell (HP:0006802)2.22512955
45Degeneration of anterior horn cells (HP:0002398)2.22512955
46Abnormality of T cell physiology (HP:0011840)2.21315674
47Adactyly (HP:0009776)2.19096872
48Colon cancer (HP:0003003)2.17926030
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17740267
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.17300459
51Abnormality of T cells (HP:0002843)2.16175668
52Lactic acidosis (HP:0003128)2.16167457
53Inability to walk (HP:0002540)2.14549108
54Increased IgM level (HP:0003496)2.11452744
55Attenuation of retinal blood vessels (HP:0007843)2.09965888
56Respiratory failure (HP:0002878)2.07346367
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06615385
58Abnormality of B cell number (HP:0010975)2.05448236
59Dyschromatopsia (HP:0007641)2.04969006
60Abnormality of T cell number (HP:0011839)2.04858395
61Large for gestational age (HP:0001520)2.03882177
62Type I transferrin isoform profile (HP:0003642)2.02657757
63Renal Fanconi syndrome (HP:0001994)2.01780962
64Increased intramyocellular lipid droplets (HP:0012240)2.00269373
65Molar tooth sign on MRI (HP:0002419)1.98648387
66Abnormality of midbrain morphology (HP:0002418)1.98648387
67Sensory axonal neuropathy (HP:0003390)1.98209644
68Nephronophthisis (HP:0000090)1.98126259
69Abnormal rod and cone electroretinograms (HP:0008323)1.97847452
70Exercise intolerance (HP:0003546)1.97720503
71Methylmalonic aciduria (HP:0012120)1.96535370
72Encephalitis (HP:0002383)1.96333630
73Pendular nystagmus (HP:0012043)1.94779494
74Exertional dyspnea (HP:0002875)1.94576525
75Abnormal albumin level (HP:0012116)1.93048844
76Hypoalbuminemia (HP:0003073)1.93048844
77Volvulus (HP:0002580)1.91553587
78Abnormality of eosinophils (HP:0001879)1.91447372
79Leukodystrophy (HP:0002415)1.89576704
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88658461
81Abnormality of alanine metabolism (HP:0010916)1.88658461
82Hyperalaninemia (HP:0003348)1.88658461
83Tongue fasciculations (HP:0001308)1.88362712
84Joint swelling (HP:0001386)1.87814310
85Lethargy (HP:0001254)1.87448851
86Aplasia/hypoplasia of the uterus (HP:0008684)1.87396397
87Abnormality of renal resorption (HP:0011038)1.86369216
88Chronic hepatic failure (HP:0100626)1.86325680
89Increased muscle lipid content (HP:0009058)1.85845835
90Neoplasm of the adrenal gland (HP:0100631)1.84909803
91Prostate neoplasm (HP:0100787)1.84604142
92Ketoacidosis (HP:0001993)1.81997397
93B lymphocytopenia (HP:0010976)1.81937650
94Ependymoma (HP:0002888)1.81300784
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80897883
96Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80897883
97T lymphocytopenia (HP:0005403)1.78734085
98Progressive microcephaly (HP:0000253)1.78688322
99Palpitations (HP:0001962)1.75643943
100Anorexia (HP:0002039)1.73916836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.01278936
2VRK23.75328822
3TSSK63.36129461
4MST43.27649632
5ZAK3.22299317
6FRK2.90853381
7NUAK12.69390013
8BCKDK2.51171139
9TXK2.50129779
10MAP2K62.47121590
11TLK12.20502283
12EIF2AK12.14983176
13VRK11.96480130
14GRK11.93175197
15BRSK21.84975508
16ADRBK21.80506977
17BUB11.77683409
18MAP4K21.76587618
19NEK11.65145692
20MAPKAPK31.64217586
21TAOK31.54879148
22CAMKK21.54765080
23PLK31.51208109
24TAF11.46796810
25NME11.42602846
26BMPR1B1.41690411
27BCR1.37427271
28CSNK1G31.37279745
29PIK3CG1.31848650
30CSNK1A1L1.25808735
31TIE11.24439186
32CSNK1G11.22977622
33SRPK11.19183187
34TNK21.16754419
35MAP4K11.09228057
36STK391.08978730
37ACVR1B1.08430637
38OXSR11.06650408
39STK161.04336395
40CSNK1G21.03065768
41SCYL20.99491859
42EIF2AK20.97617048
43BRSK10.97522679
44DAPK10.95305643
45INSRR0.95200555
46PAK30.95114750
47TEC0.94640386
48MAP2K70.91111785
49FES0.88066329
50ITK0.87137168
51MAP3K120.81767753
52PINK10.81341471
53TESK20.78101026
54KDR0.76926268
55WNK40.75455258
56TRIM280.74398583
57WNK30.71997244
58NLK0.71242056
59MAPKAPK50.69904199
60PHKG10.69820917
61PHKG20.69820917
62IKBKB0.68632133
63STK38L0.66963232
64PDK20.66864095
65ALK0.60285981
66PLK20.58733093
67ATR0.57143584
68PLK40.56843378
69MKNK20.56524808
70PRKCQ0.54735772
71GRK50.52857788
72CSNK1A10.49821503
73JAK30.46402541
74KIT0.45587101
75FER0.45437079
76SYK0.43442497
77MAPK130.43379829
78LIMK10.42719812
79RPS6KA50.40790158
80MAP3K40.39256347
81PRKCE0.39218306
82PASK0.36918437
83EPHA30.36065935
84TYK20.35340417
85ERBB30.34434521
86PLK10.34278382
87LCK0.32389940
88WEE10.31594785
89PAK60.30909045
90BTK0.30286068
91RPS6KA40.29241569
92SIK30.28983917
93IGF1R0.28924393
94LYN0.28254928
95JAK10.28157110
96CSNK2A10.27832620
97STK40.26920160
98PRKCI0.25693955
99CSNK2A20.25135685
100ADRBK10.25000020

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.89186918
2Non-homologous end-joining_Homo sapiens_hsa034502.83695764
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48805534
4One carbon pool by folate_Homo sapiens_hsa006702.45687981
5Oxidative phosphorylation_Homo sapiens_hsa001902.45192103
6Allograft rejection_Homo sapiens_hsa053302.41642975
7Protein export_Homo sapiens_hsa030602.41237681
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38671735
9Type I diabetes mellitus_Homo sapiens_hsa049402.12779072
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.10933012
11Parkinsons disease_Homo sapiens_hsa050122.10804940
12Autoimmune thyroid disease_Homo sapiens_hsa053202.08717200
13Asthma_Homo sapiens_hsa053102.04489927
14Primary immunodeficiency_Homo sapiens_hsa053402.04153080
15Graft-versus-host disease_Homo sapiens_hsa053322.03426506
16RNA polymerase_Homo sapiens_hsa030201.90771704
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80624698
18Propanoate metabolism_Homo sapiens_hsa006401.80071940
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63826628
20Base excision repair_Homo sapiens_hsa034101.63421796
21Homologous recombination_Homo sapiens_hsa034401.53873363
22Basal transcription factors_Homo sapiens_hsa030221.50319566
23RNA degradation_Homo sapiens_hsa030181.47054287
24Sulfur metabolism_Homo sapiens_hsa009201.43351894
25Phototransduction_Homo sapiens_hsa047441.41366040
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34847652
27Butanoate metabolism_Homo sapiens_hsa006501.31945892
28Antigen processing and presentation_Homo sapiens_hsa046121.30717880
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29169685
30Huntingtons disease_Homo sapiens_hsa050161.27917449
31Mismatch repair_Homo sapiens_hsa034301.22996117
32Tryptophan metabolism_Homo sapiens_hsa003801.22287234
33Linoleic acid metabolism_Homo sapiens_hsa005911.21389751
34Selenocompound metabolism_Homo sapiens_hsa004501.21198379
35Pyrimidine metabolism_Homo sapiens_hsa002401.17358711
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16718925
37DNA replication_Homo sapiens_hsa030301.15439314
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13837559
39Alzheimers disease_Homo sapiens_hsa050101.13291232
40RNA transport_Homo sapiens_hsa030131.06397336
41Fatty acid elongation_Homo sapiens_hsa000621.02936706
42Fanconi anemia pathway_Homo sapiens_hsa034601.01761359
43Purine metabolism_Homo sapiens_hsa002300.98733080
44Caffeine metabolism_Homo sapiens_hsa002320.98484786
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97333748
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96760637
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.96069692
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95373744
49Systemic lupus erythematosus_Homo sapiens_hsa053220.95267720
50Nucleotide excision repair_Homo sapiens_hsa034200.94826359
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.94650144
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93206518
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88393261
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87853407
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.87440454
56Rheumatoid arthritis_Homo sapiens_hsa053230.86494128
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84538991
58Regulation of autophagy_Homo sapiens_hsa041400.83992144
59Peroxisome_Homo sapiens_hsa041460.82869176
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77654478
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.76405534
62Hematopoietic cell lineage_Homo sapiens_hsa046400.75469245
63Measles_Homo sapiens_hsa051620.73659032
64Nitrogen metabolism_Homo sapiens_hsa009100.72659381
65Vitamin B6 metabolism_Homo sapiens_hsa007500.72645434
66Ether lipid metabolism_Homo sapiens_hsa005650.72298877
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72055154
68Spliceosome_Homo sapiens_hsa030400.69591599
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67971597
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67777233
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64375028
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64278057
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61856608
74Metabolic pathways_Homo sapiens_hsa011000.61807695
75Herpes simplex infection_Homo sapiens_hsa051680.61478733
76Chemical carcinogenesis_Homo sapiens_hsa052040.61216855
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.60586641
78Circadian rhythm_Homo sapiens_hsa047100.60067848
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57930092
80Retinol metabolism_Homo sapiens_hsa008300.57237579
81Viral myocarditis_Homo sapiens_hsa054160.53598984
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52975200
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51404092
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51174930
85Fatty acid metabolism_Homo sapiens_hsa012120.50287900
86T cell receptor signaling pathway_Homo sapiens_hsa046600.49468148
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48531983
88Fatty acid biosynthesis_Homo sapiens_hsa000610.43472369
89Epstein-Barr virus infection_Homo sapiens_hsa051690.41907345
90Fatty acid degradation_Homo sapiens_hsa000710.41348905
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.41085099
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.41033851
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.40717267
94Collecting duct acid secretion_Homo sapiens_hsa049660.39146536
95Cardiac muscle contraction_Homo sapiens_hsa042600.36514478
96Pyruvate metabolism_Homo sapiens_hsa006200.35612256
97Fat digestion and absorption_Homo sapiens_hsa049750.35331659
98Starch and sucrose metabolism_Homo sapiens_hsa005000.34626234
99Sulfur relay system_Homo sapiens_hsa041220.33126061
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31205789

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