

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.94776672 |
| 2 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.93689376 |
| 3 | DNA deamination (GO:0045006) | 5.81981668 |
| 4 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 5.30315298 |
| 5 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.88028073 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.40639858 |
| 7 | positive regulation of DNA recombination (GO:0045911) | 4.39398613 |
| 8 | positive regulation of isotype switching (GO:0045830) | 4.36701768 |
| 9 | regulation of chronic inflammatory response (GO:0002676) | 4.35772098 |
| 10 | rRNA modification (GO:0000154) | 4.27163096 |
| 11 | rRNA methylation (GO:0031167) | 4.15912974 |
| 12 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.97987147 |
| 13 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.97987147 |
| 14 | T cell differentiation involved in immune response (GO:0002292) | 3.97987147 |
| 15 | protein complex biogenesis (GO:0070271) | 3.90037393 |
| 16 | cullin deneddylation (GO:0010388) | 3.81000212 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.77727431 |
| 18 | regulation of immunoglobulin secretion (GO:0051023) | 3.76536932 |
| 19 | proteasome assembly (GO:0043248) | 3.74187713 |
| 20 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.70436248 |
| 21 | maturation of 5.8S rRNA (GO:0000460) | 3.68091295 |
| 22 | regulation of podosome assembly (GO:0071801) | 3.66165954 |
| 23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.63760535 |
| 24 | NADH dehydrogenase complex assembly (GO:0010257) | 3.63760535 |
| 25 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.63760535 |
| 26 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.62954865 |
| 27 | regulation of regulatory T cell differentiation (GO:0045589) | 3.62928596 |
| 28 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.62119775 |
| 29 | protein deneddylation (GO:0000338) | 3.59111141 |
| 30 | protein neddylation (GO:0045116) | 3.58626032 |
| 31 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.58531835 |
| 32 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.57490864 |
| 33 | regulation of response to tumor cell (GO:0002834) | 3.52224125 |
| 34 | positive regulation of response to tumor cell (GO:0002836) | 3.52224125 |
| 35 | positive regulation of immune response to tumor cell (GO:0002839) | 3.52224125 |
| 36 | regulation of immune response to tumor cell (GO:0002837) | 3.52224125 |
| 37 | pseudouridine synthesis (GO:0001522) | 3.50668547 |
| 38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.49163853 |
| 39 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.46889580 |
| 40 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.46889580 |
| 41 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.46889580 |
| 42 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.45929674 |
| 43 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.45929674 |
| 44 | signal peptide processing (GO:0006465) | 3.45439314 |
| 45 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.45431822 |
| 46 | positive regulation of B cell mediated immunity (GO:0002714) | 3.45431822 |
| 47 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.44554031 |
| 48 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.44554031 |
| 49 | isotype switching (GO:0045190) | 3.44554031 |
| 50 | GTP biosynthetic process (GO:0006183) | 3.44217454 |
| 51 | chaperone-mediated protein transport (GO:0072321) | 3.33281888 |
| 52 | amino acid activation (GO:0043038) | 3.33268280 |
| 53 | tRNA aminoacylation (GO:0043039) | 3.33268280 |
| 54 | cytidine deamination (GO:0009972) | 3.32851709 |
| 55 | cytidine metabolic process (GO:0046087) | 3.32851709 |
| 56 | cytidine catabolic process (GO:0006216) | 3.32851709 |
| 57 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.28345386 |
| 58 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.28345386 |
| 59 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.27232726 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.24079761 |
| 61 | regulation of MHC class II biosynthetic process (GO:0045346) | 3.21614472 |
| 62 | tRNA aminoacylation for protein translation (GO:0006418) | 3.19954677 |
| 63 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.19719435 |
| 64 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.19719435 |
| 65 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.17031681 |
| 66 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.14199796 |
| 67 | negative regulation of ligase activity (GO:0051352) | 3.12064499 |
| 68 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.12064499 |
| 69 | respiratory chain complex IV assembly (GO:0008535) | 3.09546290 |
| 70 | ATP synthesis coupled proton transport (GO:0015986) | 3.06331161 |
| 71 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.06331161 |
| 72 | tRNA processing (GO:0008033) | 3.05656709 |
| 73 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.05218399 |
| 74 | T-helper cell differentiation (GO:0042093) | 3.05218399 |
| 75 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.04720297 |
| 76 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.04720297 |
| 77 | alpha-beta T cell differentiation (GO:0046632) | 3.03687172 |
| 78 | tRNA metabolic process (GO:0006399) | 3.00102288 |
| 79 | UTP biosynthetic process (GO:0006228) | 3.00039766 |
| 80 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.98246562 |
| 81 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.96407412 |
| 82 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.95169339 |
| 83 | negative regulation of acute inflammatory response (GO:0002674) | 2.92638988 |
| 84 | activated T cell proliferation (GO:0050798) | 2.92461452 |
| 85 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.88282857 |
| 86 | positive regulation of immunoglobulin production (GO:0002639) | 2.88008243 |
| 87 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.82657740 |
| 88 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.81165881 |
| 89 | cytochrome complex assembly (GO:0017004) | 2.79581985 |
| 90 | peptidyl-histidine modification (GO:0018202) | 2.77207185 |
| 91 | response to pheromone (GO:0019236) | 2.75899239 |
| 92 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.75695891 |
| 93 | CTP metabolic process (GO:0046036) | 2.74660367 |
| 94 | CTP biosynthetic process (GO:0006241) | 2.74660367 |
| 95 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.74055205 |
| 96 | protein targeting to mitochondrion (GO:0006626) | 2.73817462 |
| 97 | mitochondrial RNA metabolic process (GO:0000959) | 2.73797694 |
| 98 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.72536887 |
| 99 | positive regulation of ligase activity (GO:0051351) | 2.72148784 |
| 100 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.70550027 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.21165989 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.64808720 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.14585690 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.98562689 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.43576456 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.29698848 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.97821465 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.93933024 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.85931175 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.70420402 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.66749382 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.55180474 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.46638227 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.30889486 |
| 15 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.30168320 |
| 16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.22593322 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.22271181 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.19745557 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.18472600 |
| 20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.16210383 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.02262359 |
| 22 | EWS_26573619_Chip-Seq_HEK293_Human | 1.94581255 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.93160833 |
| 24 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.91191112 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.88707709 |
| 26 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.86417676 |
| 27 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.80336688 |
| 28 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.79622456 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.76477193 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.74152593 |
| 31 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.72831274 |
| 32 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.72112366 |
| 33 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.67950963 |
| 34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.65860623 |
| 35 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.61662312 |
| 36 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53909845 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.53205352 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.52657406 |
| 39 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.45811090 |
| 40 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.45153384 |
| 41 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.44876794 |
| 42 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.43879378 |
| 43 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.41427409 |
| 44 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.39111619 |
| 45 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.38112574 |
| 46 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.38044510 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.37566889 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.32230830 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.31966181 |
| 50 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.30464933 |
| 51 | P300_19829295_ChIP-Seq_ESCs_Human | 1.28245793 |
| 52 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.26225287 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.26225287 |
| 54 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.25874843 |
| 55 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.24470447 |
| 56 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.23247294 |
| 57 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.20717395 |
| 58 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20078008 |
| 59 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19850747 |
| 60 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.19301425 |
| 61 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.18761558 |
| 62 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16910346 |
| 63 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.16600308 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14795152 |
| 65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.13021412 |
| 66 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.11176252 |
| 67 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.11176252 |
| 68 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.08615459 |
| 69 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.08377757 |
| 70 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.07942292 |
| 71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05858163 |
| 72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04076306 |
| 73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.03974903 |
| 74 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.03866861 |
| 75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02792825 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.02458338 |
| 77 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.01670422 |
| 78 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.99778596 |
| 79 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99426231 |
| 80 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99335027 |
| 81 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.99122771 |
| 82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.98795760 |
| 83 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98685377 |
| 84 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.96365410 |
| 85 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.92370573 |
| 86 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92314037 |
| 87 | AR_20517297_ChIP-Seq_VCAP_Human | 0.92238403 |
| 88 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.91820210 |
| 89 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.91619199 |
| 90 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.89064127 |
| 91 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.88725285 |
| 92 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88180080 |
| 93 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.86504182 |
| 94 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86031974 |
| 95 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85727416 |
| 96 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.85334798 |
| 97 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.83698185 |
| 98 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83462945 |
| 99 | GATA1_22025678_ChIP-Seq_K562_Human | 0.83249320 |
| 100 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82144905 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.72551167 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.70237136 |
| 3 | MP0001873_stomach_inflammation | 3.55270492 |
| 4 | MP0001348_abnormal_lacrimal_gland | 3.26238579 |
| 5 | MP0000685_abnormal_immune_system | 2.94789855 |
| 6 | MP0002102_abnormal_ear_morphology | 2.81509017 |
| 7 | MP0003646_muscle_fatigue | 2.81002577 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.65668407 |
| 9 | MP0005387_immune_system_phenotype | 2.44117547 |
| 10 | MP0001790_abnormal_immune_system | 2.44117547 |
| 11 | MP0008872_abnormal_physiological_respon | 2.38888262 |
| 12 | MP0001984_abnormal_olfaction | 2.38638458 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.22564768 |
| 14 | MP0002163_abnormal_gland_morphology | 2.08981128 |
| 15 | MP0008058_abnormal_DNA_repair | 2.07935714 |
| 16 | MP0005379_endocrine/exocrine_gland_phen | 2.07140021 |
| 17 | MP0000372_irregular_coat_pigmentation | 2.03477455 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 2.03091038 |
| 19 | MP0003186_abnormal_redox_activity | 1.97884167 |
| 20 | MP0009785_altered_susceptibility_to | 1.93136503 |
| 21 | MP0002148_abnormal_hypersensitivity_rea | 1.87268569 |
| 22 | MP0001968_abnormal_touch/_nociception | 1.86532623 |
| 23 | MP0010094_abnormal_chromosome_stability | 1.82388159 |
| 24 | MP0002736_abnormal_nociception_after | 1.78290444 |
| 25 | MP0003195_calcinosis | 1.78035065 |
| 26 | MP0005310_abnormal_salivary_gland | 1.76425523 |
| 27 | MP0002138_abnormal_hepatobiliary_system | 1.70788957 |
| 28 | MP0004885_abnormal_endolymph | 1.67891542 |
| 29 | MP0002837_dystrophic_cardiac_calcinosis | 1.63215534 |
| 30 | MP0004145_abnormal_muscle_electrophysio | 1.61744577 |
| 31 | MP0004782_abnormal_surfactant_physiolog | 1.61378589 |
| 32 | MP0005551_abnormal_eye_electrophysiolog | 1.59997041 |
| 33 | MP0002938_white_spotting | 1.59205262 |
| 34 | MP0003786_premature_aging | 1.57352417 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.51189459 |
| 36 | MP0001800_abnormal_humoral_immune | 1.50074730 |
| 37 | MP0002166_altered_tumor_susceptibility | 1.46832100 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.46474953 |
| 39 | MP0005645_abnormal_hypothalamus_physiol | 1.45260113 |
| 40 | MP0005167_abnormal_blood-brain_barrier | 1.40893594 |
| 41 | MP0002876_abnormal_thyroid_physiology | 1.39249167 |
| 42 | MP0001986_abnormal_taste_sensitivity | 1.30868949 |
| 43 | MP0003011_delayed_dark_adaptation | 1.26794092 |
| 44 | MP0005000_abnormal_immune_tolerance | 1.26750095 |
| 45 | MP0002006_tumorigenesis | 1.22918313 |
| 46 | MP0004142_abnormal_muscle_tone | 1.22059254 |
| 47 | MP0002277_abnormal_respiratory_mucosa | 1.18842623 |
| 48 | MP0002405_respiratory_system_inflammati | 1.18553993 |
| 49 | MP0005083_abnormal_biliary_tract | 1.17559916 |
| 50 | MP0001853_heart_inflammation | 1.17121723 |
| 51 | MP0003866_abnormal_defecation | 1.16878945 |
| 52 | MP0006082_CNS_inflammation | 1.15893897 |
| 53 | MP0002693_abnormal_pancreas_physiology | 1.15464432 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07920401 |
| 55 | MP0004742_abnormal_vestibular_system | 1.06781631 |
| 56 | MP0002723_abnormal_immune_serum | 1.06602208 |
| 57 | MP0006035_abnormal_mitochondrial_morpho | 1.03456805 |
| 58 | MP0003718_maternal_effect | 1.02406204 |
| 59 | MP0008775_abnormal_heart_ventricle | 1.02205255 |
| 60 | MP0009764_decreased_sensitivity_to | 1.00608686 |
| 61 | MP0010155_abnormal_intestine_physiology | 1.00593432 |
| 62 | MP0004147_increased_porphyrin_level | 0.97246002 |
| 63 | MP0002234_abnormal_pharynx_morphology | 0.96976480 |
| 64 | MP0003806_abnormal_nucleotide_metabolis | 0.91898694 |
| 65 | MP0004957_abnormal_blastocyst_morpholog | 0.89557134 |
| 66 | MP0001501_abnormal_sleep_pattern | 0.88845544 |
| 67 | MP0001905_abnormal_dopamine_level | 0.88489833 |
| 68 | MP0002272_abnormal_nervous_system | 0.87985348 |
| 69 | MP0001663_abnormal_digestive_system | 0.86549607 |
| 70 | MP0001845_abnormal_inflammatory_respons | 0.85965089 |
| 71 | MP0002420_abnormal_adaptive_immunity | 0.84424641 |
| 72 | MP0005075_abnormal_melanosome_morpholog | 0.84244012 |
| 73 | MP0006292_abnormal_olfactory_placode | 0.83120991 |
| 74 | MP0006072_abnormal_retinal_apoptosis | 0.82885868 |
| 75 | MP0004215_abnormal_myocardial_fiber | 0.81408536 |
| 76 | MP0001819_abnormal_immune_cell | 0.80971364 |
| 77 | MP0001764_abnormal_homeostasis | 0.80597151 |
| 78 | MP0009046_muscle_twitch | 0.79257570 |
| 79 | MP0000427_abnormal_hair_cycle | 0.78366041 |
| 80 | MP0002933_joint_inflammation | 0.74819137 |
| 81 | MP0005389_reproductive_system_phenotype | 0.73475462 |
| 82 | MP0001529_abnormal_vocalization | 0.73340259 |
| 83 | MP0002452_abnormal_antigen_presenting | 0.73273703 |
| 84 | MP0001919_abnormal_reproductive_system | 0.71940083 |
| 85 | MP0009745_abnormal_behavioral_response | 0.71276386 |
| 86 | MP0005319_abnormal_enzyme/_coenzyme | 0.69663407 |
| 87 | MP0000689_abnormal_spleen_morphology | 0.67194891 |
| 88 | MP0005025_abnormal_response_to | 0.65201404 |
| 89 | MP0005332_abnormal_amino_acid | 0.65111866 |
| 90 | MP0003045_fibrosis | 0.64579170 |
| 91 | MP0005636_abnormal_mineral_homeostasis | 0.63040654 |
| 92 | MP0003077_abnormal_cell_cycle | 0.62893033 |
| 93 | MP0002210_abnormal_sex_determination | 0.60892370 |
| 94 | MP0008789_abnormal_olfactory_epithelium | 0.58617961 |
| 95 | MP0000490_abnormal_crypts_of | 0.58524190 |
| 96 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.56656445 |
| 97 | MP0009697_abnormal_copulation | 0.55246826 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.54727177 |
| 99 | MP0003936_abnormal_reproductive_system | 0.54446328 |
| 100 | MP0008007_abnormal_cellular_replicative | 0.54278847 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.57903799 |
| 2 | Progressive macrocephaly (HP:0004481) | 4.15910824 |
| 3 | Increased CSF lactate (HP:0002490) | 4.02686568 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.01987523 |
| 5 | Acute encephalopathy (HP:0006846) | 3.98825614 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.90368404 |
| 7 | Stomatitis (HP:0010280) | 3.63013991 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.60351721 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.45920612 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.33976488 |
| 11 | Colon cancer (HP:0003003) | 3.19734189 |
| 12 | Increased serum lactate (HP:0002151) | 3.19067114 |
| 13 | Methylmalonic acidemia (HP:0002912) | 3.18562548 |
| 14 | Progressive inability to walk (HP:0002505) | 3.17138298 |
| 15 | Increased IgM level (HP:0003496) | 3.15643046 |
| 16 | Hepatic necrosis (HP:0002605) | 3.15151758 |
| 17 | Optic disc pallor (HP:0000543) | 3.06630796 |
| 18 | Pancreatic cysts (HP:0001737) | 3.05726025 |
| 19 | Increased serum pyruvate (HP:0003542) | 3.05526042 |
| 20 | Hypoproteinemia (HP:0003075) | 3.04327014 |
| 21 | Lipid accumulation in hepatocytes (HP:0006561) | 3.01932049 |
| 22 | IgG deficiency (HP:0004315) | 2.87741712 |
| 23 | Cerebral edema (HP:0002181) | 2.85105809 |
| 24 | Methylmalonic aciduria (HP:0012120) | 2.81526044 |
| 25 | Abnormality of glycolysis (HP:0004366) | 2.75749398 |
| 26 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.60597648 |
| 27 | Abnormal biliary tract physiology (HP:0012439) | 2.59902434 |
| 28 | Bile duct proliferation (HP:0001408) | 2.59902434 |
| 29 | Abnormality of the renal cortex (HP:0011035) | 2.56540152 |
| 30 | Abnormality of midbrain morphology (HP:0002418) | 2.55671814 |
| 31 | Molar tooth sign on MRI (HP:0002419) | 2.55671814 |
| 32 | Abnormality of alanine metabolism (HP:0010916) | 2.52431517 |
| 33 | Hyperalaninemia (HP:0003348) | 2.52431517 |
| 34 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.52431517 |
| 35 | Neoplasm of the adrenal cortex (HP:0100641) | 2.50599461 |
| 36 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.42265209 |
| 37 | Lactic acidosis (HP:0003128) | 2.42078437 |
| 38 | Cutaneous melanoma (HP:0012056) | 2.39803173 |
| 39 | Ependymoma (HP:0002888) | 2.39550573 |
| 40 | Congenital stationary night blindness (HP:0007642) | 2.37583356 |
| 41 | Neoplasm of the adrenal gland (HP:0100631) | 2.36048862 |
| 42 | Abolished electroretinogram (ERG) (HP:0000550) | 2.35712080 |
| 43 | Exercise intolerance (HP:0003546) | 2.35471350 |
| 44 | Respiratory failure (HP:0002878) | 2.35230749 |
| 45 | Inability to walk (HP:0002540) | 2.31116810 |
| 46 | Hypoplasia of the uterus (HP:0000013) | 2.29322468 |
| 47 | Renal Fanconi syndrome (HP:0001994) | 2.27527989 |
| 48 | Exertional dyspnea (HP:0002875) | 2.26217050 |
| 49 | Dyschromatopsia (HP:0007641) | 2.22068688 |
| 50 | Abnormality of T cell number (HP:0011839) | 2.21359569 |
| 51 | Abnormality of the anterior horn cell (HP:0006802) | 2.21291600 |
| 52 | Degeneration of anterior horn cells (HP:0002398) | 2.21291600 |
| 53 | Lethargy (HP:0001254) | 2.18097761 |
| 54 | True hermaphroditism (HP:0010459) | 2.17844361 |
| 55 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08168759 |
| 56 | Leukodystrophy (HP:0002415) | 2.06953008 |
| 57 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.06802741 |
| 58 | Abnormality of the labia minora (HP:0012880) | 2.06021462 |
| 59 | Nephronophthisis (HP:0000090) | 2.05002733 |
| 60 | Progressive microcephaly (HP:0000253) | 2.02267125 |
| 61 | Pancreatic fibrosis (HP:0100732) | 2.00036363 |
| 62 | Type I transferrin isoform profile (HP:0003642) | 1.99328588 |
| 63 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.97834650 |
| 64 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.97834650 |
| 65 | Chronic diarrhea (HP:0002028) | 1.97659997 |
| 66 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.96027383 |
| 67 | Autoimmune hemolytic anemia (HP:0001890) | 1.95731905 |
| 68 | Abnormality of vitamin B metabolism (HP:0004340) | 1.95612189 |
| 69 | Attenuation of retinal blood vessels (HP:0007843) | 1.94961867 |
| 70 | Microvesicular hepatic steatosis (HP:0001414) | 1.93737679 |
| 71 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.91219502 |
| 72 | Abnormality of the renal medulla (HP:0100957) | 1.91155422 |
| 73 | Hyperglycinemia (HP:0002154) | 1.89594654 |
| 74 | Large for gestational age (HP:0001520) | 1.89448577 |
| 75 | IgA deficiency (HP:0002720) | 1.89200018 |
| 76 | Abnormality of the pons (HP:0007361) | 1.86047530 |
| 77 | X-linked dominant inheritance (HP:0001423) | 1.84560407 |
| 78 | Respiratory difficulties (HP:0002880) | 1.84251342 |
| 79 | Delayed CNS myelination (HP:0002188) | 1.82940080 |
| 80 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.82131365 |
| 81 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.80994394 |
| 82 | CNS demyelination (HP:0007305) | 1.80990736 |
| 83 | Amniotic constriction ring (HP:0009775) | 1.80924259 |
| 84 | Abnormality of placental membranes (HP:0011409) | 1.80924259 |
| 85 | Abnormality of T cells (HP:0002843) | 1.80793693 |
| 86 | Abnormal albumin level (HP:0012116) | 1.78263255 |
| 87 | Hypoalbuminemia (HP:0003073) | 1.78263255 |
| 88 | Clubbing of toes (HP:0100760) | 1.75332128 |
| 89 | Hypoplasia of the pons (HP:0012110) | 1.74658682 |
| 90 | Biliary tract neoplasm (HP:0100574) | 1.73625809 |
| 91 | Amaurosis fugax (HP:0100576) | 1.73551566 |
| 92 | Constricted visual fields (HP:0001133) | 1.73310739 |
| 93 | T lymphocytopenia (HP:0005403) | 1.73174035 |
| 94 | Conjunctival hamartoma (HP:0100780) | 1.73162713 |
| 95 | Tongue fasciculations (HP:0001308) | 1.71323183 |
| 96 | Pancytopenia (HP:0001876) | 1.70051465 |
| 97 | Glioma (HP:0009733) | 1.69579258 |
| 98 | Limb hypertonia (HP:0002509) | 1.68856423 |
| 99 | Pendular nystagmus (HP:0012043) | 1.67943215 |
| 100 | Poor head control (HP:0002421) | 1.67436451 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.99181471 |
| 2 | TIE1 | 3.59728011 |
| 3 | NUAK1 | 3.49932793 |
| 4 | TSSK6 | 3.48032865 |
| 5 | FRK | 3.00410107 |
| 6 | TAF1 | 2.88422943 |
| 7 | TXK | 2.75379099 |
| 8 | MST4 | 2.45419917 |
| 9 | EIF2AK3 | 2.41450406 |
| 10 | PBK | 2.27204532 |
| 11 | BMPR1B | 2.25384720 |
| 12 | TRIM28 | 2.22328405 |
| 13 | VRK1 | 2.13110162 |
| 14 | GRK1 | 2.08351063 |
| 15 | NME1 | 2.08312382 |
| 16 | EIF2AK1 | 2.03581753 |
| 17 | BCR | 1.98586888 |
| 18 | ADRBK2 | 1.84974865 |
| 19 | MAP3K12 | 1.79317495 |
| 20 | NEK1 | 1.77368200 |
| 21 | BUB1 | 1.72452898 |
| 22 | PLK3 | 1.70234467 |
| 23 | SRPK1 | 1.52932154 |
| 24 | CSNK1G3 | 1.51506879 |
| 25 | TEC | 1.47851707 |
| 26 | DAPK1 | 1.44896096 |
| 27 | MAPKAPK3 | 1.44226385 |
| 28 | TNIK | 1.43057086 |
| 29 | ZAK | 1.41183887 |
| 30 | CSNK1A1L | 1.36817702 |
| 31 | CSNK1G1 | 1.29283549 |
| 32 | EIF2AK2 | 1.23692687 |
| 33 | ACVR1B | 1.17694413 |
| 34 | MAPKAPK5 | 1.17276744 |
| 35 | CSNK1G2 | 1.14944196 |
| 36 | BCKDK | 1.10988987 |
| 37 | SIK3 | 1.07408665 |
| 38 | OXSR1 | 1.03576464 |
| 39 | PLK2 | 1.02394853 |
| 40 | TGFBR1 | 1.00778933 |
| 41 | PDK2 | 1.00514724 |
| 42 | TAOK3 | 0.94761143 |
| 43 | GRK5 | 0.82497303 |
| 44 | MAP4K1 | 0.82426004 |
| 45 | DYRK2 | 0.81095255 |
| 46 | TLK1 | 0.80854307 |
| 47 | CASK | 0.78902274 |
| 48 | CDK19 | 0.75547531 |
| 49 | MYLK | 0.73671487 |
| 50 | WNK3 | 0.72529993 |
| 51 | MAP2K6 | 0.69407891 |
| 52 | PAK3 | 0.69316921 |
| 53 | PAK4 | 0.68788249 |
| 54 | CCNB1 | 0.67173106 |
| 55 | WNK4 | 0.66108510 |
| 56 | IKBKB | 0.64521772 |
| 57 | MAPK13 | 0.60471104 |
| 58 | INSRR | 0.60057221 |
| 59 | SMG1 | 0.59246054 |
| 60 | MKNK1 | 0.57337488 |
| 61 | PHKG2 | 0.56129353 |
| 62 | PHKG1 | 0.56129353 |
| 63 | CAMKK2 | 0.55918046 |
| 64 | FGFR2 | 0.54314468 |
| 65 | STK39 | 0.53552875 |
| 66 | DAPK3 | 0.52134211 |
| 67 | PRKCG | 0.51608693 |
| 68 | FES | 0.50938352 |
| 69 | AKT3 | 0.50219320 |
| 70 | PASK | 0.48249238 |
| 71 | PRKCE | 0.48178901 |
| 72 | STK3 | 0.47842608 |
| 73 | TGFBR2 | 0.47648197 |
| 74 | MAP3K4 | 0.46298784 |
| 75 | STK4 | 0.46107493 |
| 76 | FER | 0.45572939 |
| 77 | ATR | 0.44931262 |
| 78 | PLK1 | 0.44302049 |
| 79 | ITK | 0.42612737 |
| 80 | KDR | 0.39115882 |
| 81 | NLK | 0.39055531 |
| 82 | PLK4 | 0.38701143 |
| 83 | MKNK2 | 0.37068634 |
| 84 | STK38L | 0.35596596 |
| 85 | PRKCI | 0.35577497 |
| 86 | DAPK2 | 0.34048440 |
| 87 | MARK3 | 0.32458980 |
| 88 | CSNK1A1 | 0.32404127 |
| 89 | STK16 | 0.32242750 |
| 90 | ADRBK1 | 0.32064587 |
| 91 | PIM2 | 0.31442083 |
| 92 | CDC7 | 0.29120997 |
| 93 | TTK | 0.28926706 |
| 94 | MAP4K2 | 0.28181652 |
| 95 | PINK1 | 0.28015223 |
| 96 | ERBB3 | 0.27745882 |
| 97 | CSNK2A2 | 0.27134247 |
| 98 | CDK8 | 0.25492731 |
| 99 | CAMK2A | 0.24371586 |
| 100 | CSNK2A1 | 0.23291619 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.26140892 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.85315163 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.68383493 |
| 4 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.62250327 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.60625769 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.47456936 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.28614591 |
| 8 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.22930302 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.13355157 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.05683398 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.04070893 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.03280757 |
| 13 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.93731720 |
| 14 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.91809170 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.91778768 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.87897156 |
| 17 | Mismatch repair_Homo sapiens_hsa03430 | 1.85488146 |
| 18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.78120007 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75589887 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.58359535 |
| 21 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.50534348 |
| 22 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.48288901 |
| 23 | Homologous recombination_Homo sapiens_hsa03440 | 1.40120414 |
| 24 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.36891807 |
| 25 | Phototransduction_Homo sapiens_hsa04744 | 1.36564362 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.35168105 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.34197100 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.31555031 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.30898415 |
| 30 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.30322748 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29686351 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.25313582 |
| 33 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.23047335 |
| 34 | RNA transport_Homo sapiens_hsa03013 | 1.21881929 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.21093906 |
| 36 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.18740126 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.12443227 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.12169613 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 1.12057479 |
| 40 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.09127021 |
| 41 | Spliceosome_Homo sapiens_hsa03040 | 1.08145909 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.03671481 |
| 43 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.03415103 |
| 44 | Base excision repair_Homo sapiens_hsa03410 | 0.97480046 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 0.96693349 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.95907984 |
| 47 | Ribosome_Homo sapiens_hsa03010 | 0.94420437 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91814517 |
| 49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.88721669 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.87188153 |
| 51 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84000348 |
| 52 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.80937522 |
| 53 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.80006616 |
| 54 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.79609475 |
| 55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79606970 |
| 56 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.79546887 |
| 57 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.79444979 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78691568 |
| 59 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77683036 |
| 60 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.77293078 |
| 61 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.76984523 |
| 62 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.75543406 |
| 63 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.74390118 |
| 64 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.72869424 |
| 65 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.70377187 |
| 66 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.67952508 |
| 67 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.67200845 |
| 68 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.66649937 |
| 69 | Sulfur relay system_Homo sapiens_hsa04122 | 0.64405848 |
| 70 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.64072401 |
| 71 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62748129 |
| 72 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.61669507 |
| 73 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61354318 |
| 74 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.60242341 |
| 75 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60123991 |
| 76 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59853458 |
| 77 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.59121848 |
| 78 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.59084870 |
| 79 | Measles_Homo sapiens_hsa05162 | 0.58405995 |
| 80 | Carbon metabolism_Homo sapiens_hsa01200 | 0.56332501 |
| 81 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.55796084 |
| 82 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54477317 |
| 83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53284963 |
| 84 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.50211266 |
| 85 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47571049 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.47247218 |
| 87 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46749471 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45972127 |
| 89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44918113 |
| 90 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43932817 |
| 91 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.43412597 |
| 92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.40836674 |
| 93 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37663077 |
| 94 | Mineral absorption_Homo sapiens_hsa04978 | 0.36154932 |
| 95 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.35616592 |
| 96 | Retinol metabolism_Homo sapiens_hsa00830 | 0.34401725 |
| 97 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.32925783 |
| 98 | Nicotine addiction_Homo sapiens_hsa05033 | 0.31820598 |
| 99 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.30551523 |
| 100 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.30186210 |

