TPI1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)5.94776672
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.93689376
3DNA deamination (GO:0045006)5.81981668
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.30315298
5water-soluble vitamin biosynthetic process (GO:0042364)4.88028073
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.40639858
7positive regulation of DNA recombination (GO:0045911)4.39398613
8positive regulation of isotype switching (GO:0045830)4.36701768
9regulation of chronic inflammatory response (GO:0002676)4.35772098
10rRNA modification (GO:0000154)4.27163096
11rRNA methylation (GO:0031167)4.15912974
12alpha-beta T cell differentiation involved in immune response (GO:0002293)3.97987147
13alpha-beta T cell activation involved in immune response (GO:0002287)3.97987147
14T cell differentiation involved in immune response (GO:0002292)3.97987147
15protein complex biogenesis (GO:0070271)3.90037393
16cullin deneddylation (GO:0010388)3.81000212
17mitochondrial respiratory chain complex assembly (GO:0033108)3.77727431
18regulation of immunoglobulin secretion (GO:0051023)3.76536932
19proteasome assembly (GO:0043248)3.74187713
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.70436248
21maturation of 5.8S rRNA (GO:0000460)3.68091295
22regulation of podosome assembly (GO:0071801)3.66165954
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.63760535
24NADH dehydrogenase complex assembly (GO:0010257)3.63760535
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63760535
26regulation of cellular amino acid metabolic process (GO:0006521)3.62954865
27regulation of regulatory T cell differentiation (GO:0045589)3.62928596
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62119775
29protein deneddylation (GO:0000338)3.59111141
30protein neddylation (GO:0045116)3.58626032
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58531835
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.57490864
33regulation of response to tumor cell (GO:0002834)3.52224125
34positive regulation of response to tumor cell (GO:0002836)3.52224125
35positive regulation of immune response to tumor cell (GO:0002839)3.52224125
36regulation of immune response to tumor cell (GO:0002837)3.52224125
37pseudouridine synthesis (GO:0001522)3.50668547
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49163853
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46889580
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46889580
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46889580
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45929674
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45929674
44signal peptide processing (GO:0006465)3.45439314
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.45431822
46positive regulation of B cell mediated immunity (GO:0002714)3.45431822
47somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.44554031
48somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.44554031
49isotype switching (GO:0045190)3.44554031
50GTP biosynthetic process (GO:0006183)3.44217454
51chaperone-mediated protein transport (GO:0072321)3.33281888
52amino acid activation (GO:0043038)3.33268280
53tRNA aminoacylation (GO:0043039)3.33268280
54cytidine deamination (GO:0009972)3.32851709
55cytidine metabolic process (GO:0046087)3.32851709
56cytidine catabolic process (GO:0006216)3.32851709
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28345386
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.28345386
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27232726
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.24079761
61regulation of MHC class II biosynthetic process (GO:0045346)3.21614472
62tRNA aminoacylation for protein translation (GO:0006418)3.19954677
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.19719435
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19719435
65regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.17031681
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14199796
67negative regulation of ligase activity (GO:0051352)3.12064499
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12064499
69respiratory chain complex IV assembly (GO:0008535)3.09546290
70ATP synthesis coupled proton transport (GO:0015986)3.06331161
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06331161
72tRNA processing (GO:0008033)3.05656709
73CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.05218399
74T-helper cell differentiation (GO:0042093)3.05218399
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04720297
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04720297
77alpha-beta T cell differentiation (GO:0046632)3.03687172
78tRNA metabolic process (GO:0006399)3.00102288
79UTP biosynthetic process (GO:0006228)3.00039766
80pyrimidine ribonucleoside catabolic process (GO:0046133)2.98246562
81positive regulation of chemokine biosynthetic process (GO:0045080)2.96407412
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95169339
83negative regulation of acute inflammatory response (GO:0002674)2.92638988
84activated T cell proliferation (GO:0050798)2.92461452
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88282857
86positive regulation of immunoglobulin production (GO:0002639)2.88008243
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82657740
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81165881
89cytochrome complex assembly (GO:0017004)2.79581985
90peptidyl-histidine modification (GO:0018202)2.77207185
91response to pheromone (GO:0019236)2.75899239
92CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.75695891
93CTP metabolic process (GO:0046036)2.74660367
94CTP biosynthetic process (GO:0006241)2.74660367
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74055205
96protein targeting to mitochondrion (GO:0006626)2.73817462
97mitochondrial RNA metabolic process (GO:0000959)2.73797694
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72536887
99positive regulation of ligase activity (GO:0051351)2.72148784
100negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.70550027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.21165989
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.64808720
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.14585690
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98562689
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43576456
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29698848
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.97821465
8ZNF274_21170338_ChIP-Seq_K562_Hela2.93933024
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85931175
10VDR_22108803_ChIP-Seq_LS180_Human2.70420402
11VDR_23849224_ChIP-Seq_CD4+_Human2.66749382
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55180474
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46638227
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30889486
15FOXP3_21729870_ChIP-Seq_TREG_Human2.30168320
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.22593322
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22271181
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.19745557
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.18472600
20ELK1_19687146_ChIP-ChIP_HELA_Human2.16210383
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02262359
22EWS_26573619_Chip-Seq_HEK293_Human1.94581255
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93160833
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.91191112
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88707709
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.86417676
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80336688
28IGF1R_20145208_ChIP-Seq_DFB_Human1.79622456
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76477193
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74152593
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72831274
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72112366
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.67950963
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65860623
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61662312
36MYC_18940864_ChIP-ChIP_HL60_Human1.53909845
37DCP1A_22483619_ChIP-Seq_HELA_Human1.53205352
38GABP_19822575_ChIP-Seq_HepG2_Human1.52657406
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45811090
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45153384
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44876794
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43879378
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41427409
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39111619
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38112574
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38044510
47TP53_22573176_ChIP-Seq_HFKS_Human1.37566889
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32230830
49TAF15_26573619_Chip-Seq_HEK293_Human1.31966181
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30464933
51P300_19829295_ChIP-Seq_ESCs_Human1.28245793
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26225287
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.26225287
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25874843
55TTF2_22483619_ChIP-Seq_HELA_Human1.24470447
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23247294
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20717395
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.20078008
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19850747
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19301425
61IRF1_19129219_ChIP-ChIP_H3396_Human1.18761558
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16910346
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16600308
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14795152
65GATA3_26560356_Chip-Seq_TH2_Human1.13021412
66SOX2_19829295_ChIP-Seq_ESCs_Human1.11176252
67NANOG_19829295_ChIP-Seq_ESCs_Human1.11176252
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08615459
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08377757
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07942292
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05858163
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04076306
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03974903
74HOXB7_26014856_ChIP-Seq_BT474_Human1.03866861
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.02792825
76NCOR_22424771_ChIP-Seq_293T_Human1.02458338
77ER_23166858_ChIP-Seq_MCF-7_Human1.01670422
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99778596
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99426231
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99335027
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99122771
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.98795760
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98685377
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.96365410
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.92370573
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.92314037
87AR_20517297_ChIP-Seq_VCAP_Human0.92238403
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91820210
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91619199
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.89064127
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.88725285
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88180080
93CDX2_22108803_ChIP-Seq_LS180_Human0.86504182
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86031974
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85727416
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85334798
97TCF4_22108803_ChIP-Seq_LS180_Human0.83698185
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83462945
99GATA1_22025678_ChIP-Seq_K562_Human0.83249320
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82144905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.72551167
2MP0001835_abnormal_antigen_presentation3.70237136
3MP0001873_stomach_inflammation3.55270492
4MP0001348_abnormal_lacrimal_gland3.26238579
5MP0000685_abnormal_immune_system2.94789855
6MP0002102_abnormal_ear_morphology2.81509017
7MP0003646_muscle_fatigue2.81002577
8MP0008875_abnormal_xenobiotic_pharmacok2.65668407
9MP0005387_immune_system_phenotype2.44117547
10MP0001790_abnormal_immune_system2.44117547
11MP0008872_abnormal_physiological_respon2.38888262
12MP0001984_abnormal_olfaction2.38638458
13MP0009333_abnormal_splenocyte_physiolog2.22564768
14MP0002163_abnormal_gland_morphology2.08981128
15MP0008058_abnormal_DNA_repair2.07935714
16MP0005379_endocrine/exocrine_gland_phen2.07140021
17MP0000372_irregular_coat_pigmentation2.03477455
18MP0005084_abnormal_gallbladder_morpholo2.03091038
19MP0003186_abnormal_redox_activity1.97884167
20MP0009785_altered_susceptibility_to1.93136503
21MP0002148_abnormal_hypersensitivity_rea1.87268569
22MP0001968_abnormal_touch/_nociception1.86532623
23MP0010094_abnormal_chromosome_stability1.82388159
24MP0002736_abnormal_nociception_after1.78290444
25MP0003195_calcinosis1.78035065
26MP0005310_abnormal_salivary_gland1.76425523
27MP0002138_abnormal_hepatobiliary_system1.70788957
28MP0004885_abnormal_endolymph1.67891542
29MP0002837_dystrophic_cardiac_calcinosis1.63215534
30MP0004145_abnormal_muscle_electrophysio1.61744577
31MP0004782_abnormal_surfactant_physiolog1.61378589
32MP0005551_abnormal_eye_electrophysiolog1.59997041
33MP0002938_white_spotting1.59205262
34MP0003786_premature_aging1.57352417
35MP0006036_abnormal_mitochondrial_physio1.51189459
36MP0001800_abnormal_humoral_immune1.50074730
37MP0002166_altered_tumor_susceptibility1.46832100
38MP0008877_abnormal_DNA_methylation1.46474953
39MP0005645_abnormal_hypothalamus_physiol1.45260113
40MP0005167_abnormal_blood-brain_barrier1.40893594
41MP0002876_abnormal_thyroid_physiology1.39249167
42MP0001986_abnormal_taste_sensitivity1.30868949
43MP0003011_delayed_dark_adaptation1.26794092
44MP0005000_abnormal_immune_tolerance1.26750095
45MP0002006_tumorigenesis1.22918313
46MP0004142_abnormal_muscle_tone1.22059254
47MP0002277_abnormal_respiratory_mucosa1.18842623
48MP0002405_respiratory_system_inflammati1.18553993
49MP0005083_abnormal_biliary_tract1.17559916
50MP0001853_heart_inflammation1.17121723
51MP0003866_abnormal_defecation1.16878945
52MP0006082_CNS_inflammation1.15893897
53MP0002693_abnormal_pancreas_physiology1.15464432
54MP0003567_abnormal_fetal_cardiomyocyte1.07920401
55MP0004742_abnormal_vestibular_system1.06781631
56MP0002723_abnormal_immune_serum1.06602208
57MP0006035_abnormal_mitochondrial_morpho1.03456805
58MP0003718_maternal_effect1.02406204
59MP0008775_abnormal_heart_ventricle1.02205255
60MP0009764_decreased_sensitivity_to1.00608686
61MP0010155_abnormal_intestine_physiology1.00593432
62MP0004147_increased_porphyrin_level0.97246002
63MP0002234_abnormal_pharynx_morphology0.96976480
64MP0003806_abnormal_nucleotide_metabolis0.91898694
65MP0004957_abnormal_blastocyst_morpholog0.89557134
66MP0001501_abnormal_sleep_pattern0.88845544
67MP0001905_abnormal_dopamine_level0.88489833
68MP0002272_abnormal_nervous_system0.87985348
69MP0001663_abnormal_digestive_system0.86549607
70MP0001845_abnormal_inflammatory_respons0.85965089
71MP0002420_abnormal_adaptive_immunity0.84424641
72MP0005075_abnormal_melanosome_morpholog0.84244012
73MP0006292_abnormal_olfactory_placode0.83120991
74MP0006072_abnormal_retinal_apoptosis0.82885868
75MP0004215_abnormal_myocardial_fiber0.81408536
76MP0001819_abnormal_immune_cell0.80971364
77MP0001764_abnormal_homeostasis0.80597151
78MP0009046_muscle_twitch0.79257570
79MP0000427_abnormal_hair_cycle0.78366041
80MP0002933_joint_inflammation0.74819137
81MP0005389_reproductive_system_phenotype0.73475462
82MP0001529_abnormal_vocalization0.73340259
83MP0002452_abnormal_antigen_presenting0.73273703
84MP0001919_abnormal_reproductive_system0.71940083
85MP0009745_abnormal_behavioral_response0.71276386
86MP0005319_abnormal_enzyme/_coenzyme0.69663407
87MP0000689_abnormal_spleen_morphology0.67194891
88MP0005025_abnormal_response_to0.65201404
89MP0005332_abnormal_amino_acid0.65111866
90MP0003045_fibrosis0.64579170
91MP0005636_abnormal_mineral_homeostasis0.63040654
92MP0003077_abnormal_cell_cycle0.62893033
93MP0002210_abnormal_sex_determination0.60892370
94MP0008789_abnormal_olfactory_epithelium0.58617961
95MP0000490_abnormal_crypts_of0.58524190
96MP0005584_abnormal_enzyme/coenzyme_acti0.56656445
97MP0009697_abnormal_copulation0.55246826
98MP0001485_abnormal_pinna_reflex0.54727177
99MP0003936_abnormal_reproductive_system0.54446328
100MP0008007_abnormal_cellular_replicative0.54278847

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57903799
2Progressive macrocephaly (HP:0004481)4.15910824
3Increased CSF lactate (HP:0002490)4.02686568
4Abnormal mitochondria in muscle tissue (HP:0008316)4.01987523
5Acute encephalopathy (HP:0006846)3.98825614
6Mitochondrial inheritance (HP:0001427)3.90368404
7Stomatitis (HP:0010280)3.63013991
8Hepatocellular necrosis (HP:0001404)3.60351721
93-Methylglutaconic aciduria (HP:0003535)3.45920612
10Increased hepatocellular lipid droplets (HP:0006565)3.33976488
11Colon cancer (HP:0003003)3.19734189
12Increased serum lactate (HP:0002151)3.19067114
13Methylmalonic acidemia (HP:0002912)3.18562548
14Progressive inability to walk (HP:0002505)3.17138298
15Increased IgM level (HP:0003496)3.15643046
16Hepatic necrosis (HP:0002605)3.15151758
17Optic disc pallor (HP:0000543)3.06630796
18Pancreatic cysts (HP:0001737)3.05726025
19Increased serum pyruvate (HP:0003542)3.05526042
20Hypoproteinemia (HP:0003075)3.04327014
21Lipid accumulation in hepatocytes (HP:0006561)3.01932049
22IgG deficiency (HP:0004315)2.87741712
23Cerebral edema (HP:0002181)2.85105809
24Methylmalonic aciduria (HP:0012120)2.81526044
25Abnormality of glycolysis (HP:0004366)2.75749398
26Aplasia/hypoplasia of the uterus (HP:0008684)2.60597648
27Abnormal biliary tract physiology (HP:0012439)2.59902434
28Bile duct proliferation (HP:0001408)2.59902434
29Abnormality of the renal cortex (HP:0011035)2.56540152
30Abnormality of midbrain morphology (HP:0002418)2.55671814
31Molar tooth sign on MRI (HP:0002419)2.55671814
32Abnormality of alanine metabolism (HP:0010916)2.52431517
33Hyperalaninemia (HP:0003348)2.52431517
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52431517
35Neoplasm of the adrenal cortex (HP:0100641)2.50599461
36Elevated erythrocyte sedimentation rate (HP:0003565)2.42265209
37Lactic acidosis (HP:0003128)2.42078437
38Cutaneous melanoma (HP:0012056)2.39803173
39Ependymoma (HP:0002888)2.39550573
40Congenital stationary night blindness (HP:0007642)2.37583356
41Neoplasm of the adrenal gland (HP:0100631)2.36048862
42Abolished electroretinogram (ERG) (HP:0000550)2.35712080
43Exercise intolerance (HP:0003546)2.35471350
44Respiratory failure (HP:0002878)2.35230749
45Inability to walk (HP:0002540)2.31116810
46Hypoplasia of the uterus (HP:0000013)2.29322468
47Renal Fanconi syndrome (HP:0001994)2.27527989
48Exertional dyspnea (HP:0002875)2.26217050
49Dyschromatopsia (HP:0007641)2.22068688
50Abnormality of T cell number (HP:0011839)2.21359569
51Abnormality of the anterior horn cell (HP:0006802)2.21291600
52Degeneration of anterior horn cells (HP:0002398)2.21291600
53Lethargy (HP:0001254)2.18097761
54True hermaphroditism (HP:0010459)2.17844361
55Increased intramyocellular lipid droplets (HP:0012240)2.08168759
56Leukodystrophy (HP:0002415)2.06953008
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06802741
58Abnormality of the labia minora (HP:0012880)2.06021462
59Nephronophthisis (HP:0000090)2.05002733
60Progressive microcephaly (HP:0000253)2.02267125
61Pancreatic fibrosis (HP:0100732)2.00036363
62Type I transferrin isoform profile (HP:0003642)1.99328588
63Abnormal respiratory motile cilium morphology (HP:0005938)1.97834650
64Abnormal respiratory epithelium morphology (HP:0012253)1.97834650
65Chronic diarrhea (HP:0002028)1.97659997
66Abnormality of the vitamin B12 metabolism (HP:0004341)1.96027383
67Autoimmune hemolytic anemia (HP:0001890)1.95731905
68Abnormality of vitamin B metabolism (HP:0004340)1.95612189
69Attenuation of retinal blood vessels (HP:0007843)1.94961867
70Microvesicular hepatic steatosis (HP:0001414)1.93737679
71Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91219502
72Abnormality of the renal medulla (HP:0100957)1.91155422
73Hyperglycinemia (HP:0002154)1.89594654
74Large for gestational age (HP:0001520)1.89448577
75IgA deficiency (HP:0002720)1.89200018
76Abnormality of the pons (HP:0007361)1.86047530
77X-linked dominant inheritance (HP:0001423)1.84560407
78Respiratory difficulties (HP:0002880)1.84251342
79Delayed CNS myelination (HP:0002188)1.82940080
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82131365
81Abnormal rod and cone electroretinograms (HP:0008323)1.80994394
82CNS demyelination (HP:0007305)1.80990736
83Amniotic constriction ring (HP:0009775)1.80924259
84Abnormality of placental membranes (HP:0011409)1.80924259
85Abnormality of T cells (HP:0002843)1.80793693
86Abnormal albumin level (HP:0012116)1.78263255
87Hypoalbuminemia (HP:0003073)1.78263255
88Clubbing of toes (HP:0100760)1.75332128
89Hypoplasia of the pons (HP:0012110)1.74658682
90Biliary tract neoplasm (HP:0100574)1.73625809
91Amaurosis fugax (HP:0100576)1.73551566
92Constricted visual fields (HP:0001133)1.73310739
93T lymphocytopenia (HP:0005403)1.73174035
94Conjunctival hamartoma (HP:0100780)1.73162713
95Tongue fasciculations (HP:0001308)1.71323183
96Pancytopenia (HP:0001876)1.70051465
97Glioma (HP:0009733)1.69579258
98Limb hypertonia (HP:0002509)1.68856423
99Pendular nystagmus (HP:0012043)1.67943215
100Poor head control (HP:0002421)1.67436451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.99181471
2TIE13.59728011
3NUAK13.49932793
4TSSK63.48032865
5FRK3.00410107
6TAF12.88422943
7TXK2.75379099
8MST42.45419917
9EIF2AK32.41450406
10PBK2.27204532
11BMPR1B2.25384720
12TRIM282.22328405
13VRK12.13110162
14GRK12.08351063
15NME12.08312382
16EIF2AK12.03581753
17BCR1.98586888
18ADRBK21.84974865
19MAP3K121.79317495
20NEK11.77368200
21BUB11.72452898
22PLK31.70234467
23SRPK11.52932154
24CSNK1G31.51506879
25TEC1.47851707
26DAPK11.44896096
27MAPKAPK31.44226385
28TNIK1.43057086
29ZAK1.41183887
30CSNK1A1L1.36817702
31CSNK1G11.29283549
32EIF2AK21.23692687
33ACVR1B1.17694413
34MAPKAPK51.17276744
35CSNK1G21.14944196
36BCKDK1.10988987
37SIK31.07408665
38OXSR11.03576464
39PLK21.02394853
40TGFBR11.00778933
41PDK21.00514724
42TAOK30.94761143
43GRK50.82497303
44MAP4K10.82426004
45DYRK20.81095255
46TLK10.80854307
47CASK0.78902274
48CDK190.75547531
49MYLK0.73671487
50WNK30.72529993
51MAP2K60.69407891
52PAK30.69316921
53PAK40.68788249
54CCNB10.67173106
55WNK40.66108510
56IKBKB0.64521772
57MAPK130.60471104
58INSRR0.60057221
59SMG10.59246054
60MKNK10.57337488
61PHKG20.56129353
62PHKG10.56129353
63CAMKK20.55918046
64FGFR20.54314468
65STK390.53552875
66DAPK30.52134211
67PRKCG0.51608693
68FES0.50938352
69AKT30.50219320
70PASK0.48249238
71PRKCE0.48178901
72STK30.47842608
73TGFBR20.47648197
74MAP3K40.46298784
75STK40.46107493
76FER0.45572939
77ATR0.44931262
78PLK10.44302049
79ITK0.42612737
80KDR0.39115882
81NLK0.39055531
82PLK40.38701143
83MKNK20.37068634
84STK38L0.35596596
85PRKCI0.35577497
86DAPK20.34048440
87MARK30.32458980
88CSNK1A10.32404127
89STK160.32242750
90ADRBK10.32064587
91PIM20.31442083
92CDC70.29120997
93TTK0.28926706
94MAP4K20.28181652
95PINK10.28015223
96ERBB30.27745882
97CSNK2A20.27134247
98CDK80.25492731
99CAMK2A0.24371586
100CSNK2A10.23291619

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.26140892
2Protein export_Homo sapiens_hsa030603.85315163
3Oxidative phosphorylation_Homo sapiens_hsa001902.68383493
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62250327
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60625769
6Allograft rejection_Homo sapiens_hsa053302.47456936
7Asthma_Homo sapiens_hsa053102.28614591
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22930302
9Parkinsons disease_Homo sapiens_hsa050122.13355157
10RNA polymerase_Homo sapiens_hsa030202.05683398
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.04070893
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03280757
13Autoimmune thyroid disease_Homo sapiens_hsa053201.93731720
14Type I diabetes mellitus_Homo sapiens_hsa049401.91809170
15RNA degradation_Homo sapiens_hsa030181.91778768
16Non-homologous end-joining_Homo sapiens_hsa034501.87897156
17Mismatch repair_Homo sapiens_hsa034301.85488146
18Propanoate metabolism_Homo sapiens_hsa006401.78120007
19Basal transcription factors_Homo sapiens_hsa030221.75589887
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58359535
21Sulfur metabolism_Homo sapiens_hsa009201.50534348
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48288901
23Homologous recombination_Homo sapiens_hsa034401.40120414
24Regulation of autophagy_Homo sapiens_hsa041401.36891807
25Phototransduction_Homo sapiens_hsa047441.36564362
26Huntingtons disease_Homo sapiens_hsa050161.35168105
27One carbon pool by folate_Homo sapiens_hsa006701.34197100
28Nucleotide excision repair_Homo sapiens_hsa034201.31555031
29Fanconi anemia pathway_Homo sapiens_hsa034601.30898415
30Graft-versus-host disease_Homo sapiens_hsa053321.30322748
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29686351
32Alzheimers disease_Homo sapiens_hsa050101.25313582
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23047335
34RNA transport_Homo sapiens_hsa030131.21881929
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21093906
36Hematopoietic cell lineage_Homo sapiens_hsa046401.18740126
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12443227
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12169613
39DNA replication_Homo sapiens_hsa030301.12057479
40Pyrimidine metabolism_Homo sapiens_hsa002401.09127021
41Spliceosome_Homo sapiens_hsa030401.08145909
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03671481
43Primary immunodeficiency_Homo sapiens_hsa053401.03415103
44Base excision repair_Homo sapiens_hsa034100.97480046
45Purine metabolism_Homo sapiens_hsa002300.96693349
46Pyruvate metabolism_Homo sapiens_hsa006200.95907984
47Ribosome_Homo sapiens_hsa030100.94420437
48Butanoate metabolism_Homo sapiens_hsa006500.91814517
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88721669
50Peroxisome_Homo sapiens_hsa041460.87188153
51Rheumatoid arthritis_Homo sapiens_hsa053230.84000348
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80937522
53Fatty acid elongation_Homo sapiens_hsa000620.80006616
54Caffeine metabolism_Homo sapiens_hsa002320.79609475
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79606970
56Collecting duct acid secretion_Homo sapiens_hsa049660.79546887
57Steroid biosynthesis_Homo sapiens_hsa001000.79444979
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.78691568
59Linoleic acid metabolism_Homo sapiens_hsa005910.77683036
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77293078
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76984523
62Nitrogen metabolism_Homo sapiens_hsa009100.75543406
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74390118
64Vitamin B6 metabolism_Homo sapiens_hsa007500.72869424
65Folate biosynthesis_Homo sapiens_hsa007900.70377187
66Selenocompound metabolism_Homo sapiens_hsa004500.67952508
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.67200845
68T cell receptor signaling pathway_Homo sapiens_hsa046600.66649937
69Sulfur relay system_Homo sapiens_hsa041220.64405848
70Antigen processing and presentation_Homo sapiens_hsa046120.64072401
71Metabolic pathways_Homo sapiens_hsa011000.62748129
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61669507
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61354318
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60242341
75Cardiac muscle contraction_Homo sapiens_hsa042600.60123991
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59853458
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59121848
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.59084870
79Measles_Homo sapiens_hsa051620.58405995
80Carbon metabolism_Homo sapiens_hsa012000.56332501
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.55796084
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54477317
83Tryptophan metabolism_Homo sapiens_hsa003800.53284963
84Glutathione metabolism_Homo sapiens_hsa004800.50211266
85N-Glycan biosynthesis_Homo sapiens_hsa005100.47571049
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.47247218
87Biosynthesis of amino acids_Homo sapiens_hsa012300.46749471
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.45972127
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44918113
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.43932817
91Ether lipid metabolism_Homo sapiens_hsa005650.43412597
92Fatty acid metabolism_Homo sapiens_hsa012120.40836674
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37663077
94Mineral absorption_Homo sapiens_hsa049780.36154932
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35616592
96Retinol metabolism_Homo sapiens_hsa008300.34401725
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32925783
98Nicotine addiction_Homo sapiens_hsa050330.31820598
99Chemical carcinogenesis_Homo sapiens_hsa052040.30551523
100Fructose and mannose metabolism_Homo sapiens_hsa000510.30186210

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