TPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.16496061
2indole-containing compound catabolic process (GO:0042436)5.16496061
3indolalkylamine catabolic process (GO:0046218)5.16496061
4aromatic amino acid family catabolic process (GO:0009074)4.98773439
5urate metabolic process (GO:0046415)4.90127053
6tryptophan metabolic process (GO:0006568)4.84527367
7L-phenylalanine metabolic process (GO:0006558)4.84512018
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.84512018
9L-phenylalanine catabolic process (GO:0006559)4.73582661
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.73582661
11drug transmembrane transport (GO:0006855)4.66322808
12homocysteine metabolic process (GO:0050667)4.62637606
13protein K11-linked deubiquitination (GO:0035871)4.46715004
14cysteine metabolic process (GO:0006534)4.39820155
15serine family amino acid catabolic process (GO:0009071)4.38880757
16glyoxylate metabolic process (GO:0046487)4.37048275
17regulation of B cell receptor signaling pathway (GO:0050855)4.29898192
18drug transport (GO:0015893)4.14247986
19glycine metabolic process (GO:0006544)4.11380370
20serine family amino acid metabolic process (GO:0009069)4.06378793
21piRNA metabolic process (GO:0034587)4.04500814
22kynurenine metabolic process (GO:0070189)3.99497044
23cellular biogenic amine catabolic process (GO:0042402)3.95978852
24amine catabolic process (GO:0009310)3.95978852
25lysine catabolic process (GO:0006554)3.89148220
26lysine metabolic process (GO:0006553)3.89148220
27amino-acid betaine metabolic process (GO:0006577)3.88264752
28interferon-gamma production (GO:0032609)3.84118373
29aromatic amino acid family metabolic process (GO:0009072)3.77773570
30positive regulation of gamma-delta T cell activation (GO:0046645)3.76771949
31proline metabolic process (GO:0006560)3.74916390
32serine family amino acid biosynthetic process (GO:0009070)3.73422161
33indolalkylamine metabolic process (GO:0006586)3.72371253
34imidazole-containing compound metabolic process (GO:0052803)3.70950097
35NAD biosynthetic process (GO:0009435)3.59103492
36drug catabolic process (GO:0042737)3.57797708
37tetrahydrofolate metabolic process (GO:0046653)3.46491702
38branched-chain amino acid catabolic process (GO:0009083)3.34573885
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34400629
40multicellular organism reproduction (GO:0032504)3.32423769
41alpha-amino acid catabolic process (GO:1901606)3.32204962
42organic cation transport (GO:0015695)3.27102937
43aminoglycoside antibiotic metabolic process (GO:0030647)3.26365912
44adaptation of signaling pathway (GO:0023058)3.23818897
45bile acid metabolic process (GO:0008206)3.22615140
46pteridine-containing compound biosynthetic process (GO:0042559)3.20273651
47bile acid biosynthetic process (GO:0006699)3.19316238
48folic acid-containing compound metabolic process (GO:0006760)3.18920402
49neutrophil activation involved in immune response (GO:0002283)3.18427306
50detection of light stimulus involved in sensory perception (GO:0050962)3.18212280
51detection of light stimulus involved in visual perception (GO:0050908)3.18212280
52folic acid metabolic process (GO:0046655)3.17394008
53pteridine-containing compound metabolic process (GO:0042558)3.16605572
54branched-chain amino acid metabolic process (GO:0009081)3.16512762
55bile acid and bile salt transport (GO:0015721)3.15889387
56pyridine nucleotide biosynthetic process (GO:0019363)3.15571440
57nicotinamide nucleotide biosynthetic process (GO:0019359)3.15571440
58DNA methylation involved in gamete generation (GO:0043046)3.14798420
59carnitine metabolic process (GO:0009437)3.12712895
60exogenous drug catabolic process (GO:0042738)3.12389662
61cellular amino acid catabolic process (GO:0009063)3.11126494
62negative regulation of interleukin-1 beta production (GO:0032691)3.09969305
63DNA deamination (GO:0045006)3.08090474
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03893972
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03882366
66glucocorticoid biosynthetic process (GO:0006704)3.01724135
67regulation of bile acid biosynthetic process (GO:0070857)3.00743339
68regulation of gamma-delta T cell activation (GO:0046643)3.00206467
69regulation of acrosome reaction (GO:0060046)2.99315138
70sulfur amino acid biosynthetic process (GO:0000097)2.99093493
71cell wall macromolecule metabolic process (GO:0044036)2.98545369
72urea cycle (GO:0000050)2.97936988
73urea metabolic process (GO:0019627)2.97936988
74folic acid-containing compound biosynthetic process (GO:0009396)2.97603891
75sulfur amino acid catabolic process (GO:0000098)2.96738300
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94913018
77neural tube formation (GO:0001841)2.92667437
78negative regulation of interleukin-1 production (GO:0032692)2.91978301
79cell wall macromolecule catabolic process (GO:0016998)2.91821844
80positive regulation of cellular amine metabolic process (GO:0033240)2.91416114
81cellular modified amino acid catabolic process (GO:0042219)2.91316855
82short-chain fatty acid metabolic process (GO:0046459)2.91126657
83one-carbon metabolic process (GO:0006730)2.90049979
84DNA integration (GO:0015074)2.89819017
85indole-containing compound metabolic process (GO:0042430)2.86878988
86nitrogen cycle metabolic process (GO:0071941)2.85082781
87RNA destabilization (GO:0050779)2.83591038
88adenosine metabolic process (GO:0046085)2.82106193
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.81559548
90kinetochore assembly (GO:0051382)2.81272349
91positive regulation of mast cell activation (GO:0033005)2.80356785
92negative regulation of cell killing (GO:0031342)2.79985435
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79985435
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.79826520
95glycerophospholipid catabolic process (GO:0046475)2.79575496
96sulfur amino acid metabolic process (GO:0000096)2.79436752
97aldehyde catabolic process (GO:0046185)2.79085321
98regulation of female gonad development (GO:2000194)2.78540110
99phosphate ion transport (GO:0006817)2.78367183
100proline biosynthetic process (GO:0006561)2.78212911
101regulation of meiosis I (GO:0060631)2.77450627
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77293783
103pyrimidine nucleoside catabolic process (GO:0046135)2.77106240
104carboxylic acid catabolic process (GO:0046395)2.75538584
105organic acid catabolic process (GO:0016054)2.75538584
106valine metabolic process (GO:0006573)2.74076465
107regulation of memory T cell differentiation (GO:0043380)2.73204864
108establishment of protein localization to Golgi (GO:0072600)2.72931080
109regulation of mast cell activation (GO:0033003)2.72742680
110detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.71031717
111reciprocal DNA recombination (GO:0035825)2.70793187
112reciprocal meiotic recombination (GO:0007131)2.70793187
113negative regulation of mast cell activation (GO:0033004)2.70341439
114microglial cell activation (GO:0001774)2.70319550
115blood coagulation, intrinsic pathway (GO:0007597)2.68937394
116pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.68694089
117negative regulation of cholesterol transport (GO:0032375)2.68667322
118negative regulation of sterol transport (GO:0032372)2.68667322
119regulation of helicase activity (GO:0051095)2.67071819
120benzene-containing compound metabolic process (GO:0042537)2.66383963
121regulation of cholesterol esterification (GO:0010872)2.65752107
122activated T cell proliferation (GO:0050798)2.65601571
123retinal cone cell development (GO:0046549)2.64945433
124immunoglobulin mediated immune response (GO:0016064)2.63753139
125ribosomal small subunit assembly (GO:0000028)2.63296126
126triglyceride homeostasis (GO:0070328)2.63288410
127acylglycerol homeostasis (GO:0055090)2.63288410
128basic amino acid transport (GO:0015802)2.63134916
129platelet dense granule organization (GO:0060155)2.61578362
130tachykinin receptor signaling pathway (GO:0007217)2.61365726
131tyrosine metabolic process (GO:0006570)2.60597677
132negative regulation of execution phase of apoptosis (GO:1900118)2.60449108
133photoreceptor cell maintenance (GO:0045494)2.60036258
134positive regulation of DNA recombination (GO:0045911)2.59840812
135sulfation (GO:0051923)2.59243944
136triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58935530
137negative regulation of T cell mediated immunity (GO:0002710)2.58631892
138polyol transport (GO:0015791)2.57932695
139regulation of gamma-delta T cell differentiation (GO:0045586)2.57808259
140response to nitrosative stress (GO:0051409)2.57561344
141aspartate family amino acid catabolic process (GO:0009068)2.57377081
142cytokine biosynthetic process (GO:0042089)2.56359112
143neutrophil activation (GO:0042119)2.55922974
144fatty acid beta-oxidation (GO:0006635)2.55913045
145signal peptide processing (GO:0006465)2.55866330
146xenobiotic catabolic process (GO:0042178)2.55427508
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55017880
148phosphate ion transmembrane transport (GO:0035435)2.53434832
149toxin transport (GO:1901998)2.53335955
150mast cell activation (GO:0045576)2.53222504
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52659292
152preassembly of GPI anchor in ER membrane (GO:0016254)2.52543099
153positive regulation of defense response to virus by host (GO:0002230)2.52323604
154linoleic acid metabolic process (GO:0043651)2.51414346
155high-density lipoprotein particle remodeling (GO:0034375)2.51144626
156serotonin receptor signaling pathway (GO:0007210)2.49018298
157positive regulation of isotype switching (GO:0045830)2.48831364
158macrophage activation involved in immune response (GO:0002281)2.47194275
159negative regulation of cAMP-mediated signaling (GO:0043951)2.45887949
160positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45702371
161positive regulation of histone H3-K4 methylation (GO:0051571)2.44656157
162negative regulation of interleukin-12 production (GO:0032695)2.43804128
163superoxide anion generation (GO:0042554)2.43465419
164response to peptidoglycan (GO:0032494)2.42552293
165cellular response to interleukin-15 (GO:0071350)2.41562263
166regulation of alpha-beta T cell proliferation (GO:0046640)2.40768319
167positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40444413
168positive regulation of mast cell activation involved in immune response (GO:0033008)2.40100084
169positive regulation of mast cell degranulation (GO:0043306)2.40100084
170synapsis (GO:0007129)2.39860282
171L-fucose catabolic process (GO:0042355)2.36237108
172fucose catabolic process (GO:0019317)2.36237108
173L-fucose metabolic process (GO:0042354)2.36237108
174meiotic cell cycle (GO:0051321)2.35954938
175response to pheromone (GO:0019236)2.35462233
176cilium or flagellum-dependent cell motility (GO:0001539)2.35242484
177myeloid cell activation involved in immune response (GO:0002275)2.34714634
178I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.34107162
179regulation of T cell receptor signaling pathway (GO:0050856)2.33113788
180nucleotide transmembrane transport (GO:1901679)2.32484669
181cellular ketone body metabolic process (GO:0046950)2.30701878
182modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30609114
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.30609114
184modulation by symbiont of host immune response (GO:0052553)2.30609114
185positive regulation by symbiont of host defense response (GO:0052509)2.30609114
186modulation by symbiont of host defense response (GO:0052031)2.30609114
187modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30609114
188cytokine metabolic process (GO:0042107)2.30479757
189RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.30316165
190positive regulation of humoral immune response (GO:0002922)2.29855080
191negative regulation of calcium ion transport into cytosol (GO:0010523)2.27899165
192negative T cell selection (GO:0043383)2.27524387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91619156
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.01539316
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.82171767
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.70680553
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.57794641
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.47321705
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.17534419
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.03258477
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02398963
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00250503
11EZH2_22144423_ChIP-Seq_EOC_Human2.79729881
12VDR_22108803_ChIP-Seq_LS180_Human2.73145202
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.67298187
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.64217311
15* GBX2_23144817_ChIP-Seq_PC3_Human2.62693399
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43293116
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37662665
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31614070
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.30028155
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23928266
21ZNF274_21170338_ChIP-Seq_K562_Hela2.23625126
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18495790
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16362983
24IGF1R_20145208_ChIP-Seq_DFB_Human2.11565137
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10481684
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08194941
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.06731829
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05528986
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03041207
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98764464
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98705892
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98705892
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98705892
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96935047
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96529015
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96400108
37TAF15_26573619_Chip-Seq_HEK293_Human1.94485585
38P300_19829295_ChIP-Seq_ESCs_Human1.89050338
39ER_23166858_ChIP-Seq_MCF-7_Human1.88356082
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87841486
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86789849
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78973420
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78472767
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.76903084
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76755976
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73575995
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70254266
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68178963
49BCAT_22108803_ChIP-Seq_LS180_Human1.67768090
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66432026
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66067639
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64672950
53IRF1_19129219_ChIP-ChIP_H3396_Human1.63983768
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63969081
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.63450429
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63153651
57NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61989497
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59185581
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58604115
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58585688
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58425979
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.57995107
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57310391
64CBP_20019798_ChIP-Seq_JUKART_Human1.57310391
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56020571
66EWS_26573619_Chip-Seq_HEK293_Human1.54628980
67RUNX_20019798_ChIP-Seq_JUKART_Human1.53098322
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.52323211
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50302182
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50110282
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49741577
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.48528507
73SMAD4_21799915_ChIP-Seq_A2780_Human1.46585513
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.45890842
75* STAT3_23295773_ChIP-Seq_U87_Human1.45862542
76* AR_25329375_ChIP-Seq_VCAP_Human1.43641126
77* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43538801
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43086915
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.42944313
80GATA3_26560356_Chip-Seq_TH2_Human1.41841147
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41160286
82FUS_26573619_Chip-Seq_HEK293_Human1.39432987
83* TCF4_23295773_ChIP-Seq_U87_Human1.38381731
84* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38021655
85* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36312305
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.35815160
87VDR_24787735_ChIP-Seq_THP-1_Human1.35675914
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35638044
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34673128
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34022510
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33253206
92NANOG_19829295_ChIP-Seq_ESCs_Human1.33216940
93SOX2_19829295_ChIP-Seq_ESCs_Human1.33216940
94AR_21909140_ChIP-Seq_LNCAP_Human1.32627776
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32563172
96* FOXP3_21729870_ChIP-Seq_TREG_Human1.31134529
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30454589
98TCF4_22108803_ChIP-Seq_LS180_Human1.30257345
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30154373
100TP53_22573176_ChIP-Seq_HFKS_Human1.28247925
101* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28157906
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27325541
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27237053
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26838322
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26778189
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26483600
107* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25889035
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.25369685
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24554522
110CDX2_22108803_ChIP-Seq_LS180_Human1.24351183
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.23975404
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23598839
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23575685
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20635389
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20569925
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.20499189
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20214355
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18562462
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.17667114
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.17574731
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.17277444
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.16953180
123SMRT_27268052_Chip-Seq_Bcells_Human1.16714314
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.16353941
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15992648
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15154309
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14316676
128YY1_21170310_ChIP-Seq_MESCs_Mouse1.14224493
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.14203873
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13989522
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.13929808
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13929808
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13774853
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.13302187
135CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13166934
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12018510
137RUNX2_22187159_ChIP-Seq_PCA_Human1.11633794
138* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11423341
139MYB_26560356_Chip-Seq_TH2_Human1.11198898
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10184504
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09269480
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09241119
143GATA3_27048872_Chip-Seq_THYMUS_Human1.09177380
144* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07433697
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06804679
146TP53_16413492_ChIP-PET_HCT116_Human1.06103045
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06032469
148MYC_18940864_ChIP-ChIP_HL60_Human1.05646745
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05602101
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04481965
151ETS1_20019798_ChIP-Seq_JURKAT_Human1.04118121
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04110643
153GATA3_21878914_ChIP-Seq_MCF-7_Human1.02971013
154NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02859101
155MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02474885
156FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02109468
157P53_22387025_ChIP-Seq_ESCs_Mouse1.02030647
158KAP1_27257070_Chip-Seq_ESCs_Mouse1.00670294
159IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00474477
160* AR_20517297_ChIP-Seq_VCAP_Human0.96922412
161RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95491928
162NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93480470
163YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93400753
164ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92887653
165GATA1_22025678_ChIP-Seq_K562_Human0.92854495
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92623141
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90640473
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88875652
169* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88351359
170VDR_23849224_ChIP-Seq_CD4+_Human0.88053853
171NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87972975
172TP63_19390658_ChIP-ChIP_HaCaT_Human0.87573721
173SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86345030
174GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84843740
175* GATA4_25053715_ChIP-Seq_YYC3_Human0.83874046
176POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83812962
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83509077
178RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83466270
179E2F1_21310950_ChIP-Seq_MCF-7_Human0.83417364
180EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83063411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.91907609
2MP0002139_abnormal_hepatobiliary_system5.17958279
3MP0005365_abnormal_bile_salt4.41236629
4MP0005085_abnormal_gallbladder_physiolo4.11957331
5MP0003806_abnormal_nucleotide_metabolis3.97113689
6MP0004019_abnormal_vitamin_homeostasis3.81095142
7MP0008875_abnormal_xenobiotic_pharmacok3.40993709
8MP0006082_CNS_inflammation3.12388854
9MP0003724_increased_susceptibility_to3.06875167
10MP0003252_abnormal_bile_duct2.90878866
11MP0002138_abnormal_hepatobiliary_system2.82976414
12MP0003195_calcinosis2.75071226
13MP0005332_abnormal_amino_acid2.61698886
14MP0005671_abnormal_response_to2.57597241
15MP0008058_abnormal_DNA_repair2.47908802
16MP0003011_delayed_dark_adaptation2.41394141
17MP0003183_abnormal_peptide_metabolism2.34692090
18MP0008877_abnormal_DNA_methylation2.34323184
19MP0000569_abnormal_digit_pigmentation2.21390448
20MP0005310_abnormal_salivary_gland2.20765219
21MP0002254_reproductive_system_inflammat2.19837123
22MP0005451_abnormal_body_composition2.18871770
23MP0001835_abnormal_antigen_presentation2.18318942
24MP0001666_abnormal_nutrient_absorption2.09793304
25MP0001764_abnormal_homeostasis2.01561060
26MP0003693_abnormal_embryo_hatching1.97491646
27MP0006292_abnormal_olfactory_placode1.95518749
28MP0001800_abnormal_humoral_immune1.93585831
29MP0001790_abnormal_immune_system1.92992223
30MP0005387_immune_system_phenotype1.92992223
31MP0009785_altered_susceptibility_to1.90157009
32MP0000685_abnormal_immune_system1.87722803
33MP0003868_abnormal_feces_composition1.86526570
34MP0003186_abnormal_redox_activity1.82673640
35MP0002419_abnormal_innate_immunity1.82505481
36MP0005670_abnormal_white_adipose1.82413637
37MP0003941_abnormal_skin_development1.81124405
38MP0002723_abnormal_immune_serum1.81002482
39MP0002452_abnormal_antigen_presenting1.77739547
40MP0005000_abnormal_immune_tolerance1.77304044
41MP0009643_abnormal_urine_homeostasis1.76923635
42MP0002148_abnormal_hypersensitivity_rea1.73351322
43MP0010094_abnormal_chromosome_stability1.69963702
44MP0004133_heterotaxia1.68563238
45MP0001501_abnormal_sleep_pattern1.67301630
46MP0003718_maternal_effect1.65413692
47MP0003111_abnormal_nucleus_morphology1.63032361
48MP0002420_abnormal_adaptive_immunity1.62345267
49MP0001819_abnormal_immune_cell1.61592774
50MP0010329_abnormal_lipoprotein_level1.61024415
51MP0005025_abnormal_response_to1.58934635
52MP0001188_hyperpigmentation1.53532158
53MP0005410_abnormal_fertilization1.52183375
54MP0004147_increased_porphyrin_level1.49032317
55MP0005551_abnormal_eye_electrophysiolog1.42420456
56MP0004043_abnormal_pH_regulation1.38873133
57MP0009840_abnormal_foam_cell1.36650522
58MP0005636_abnormal_mineral_homeostasis1.32430962
59MP0003786_premature_aging1.30841026
60MP0000490_abnormal_crypts_of1.30790010
61MP0000566_synostosis1.30443621
62MP0005075_abnormal_melanosome_morpholog1.29734215
63MP0002837_dystrophic_cardiac_calcinosis1.26804568
64MP0003436_decreased_susceptibility_to1.26670659
65MP0005377_hearing/vestibular/ear_phenot1.25237888
66MP0003878_abnormal_ear_physiology1.25237888
67MP0004264_abnormal_extraembryonic_tissu1.25202025
68MP0001845_abnormal_inflammatory_respons1.24472205
69MP0002405_respiratory_system_inflammati1.24344793
70MP0009697_abnormal_copulation1.24025931
71MP0005319_abnormal_enzyme/_coenzyme1.23927442
72MP0003646_muscle_fatigue1.19416389
73MP0000015_abnormal_ear_pigmentation1.19400741
74MP0003191_abnormal_cellular_cholesterol1.17935900
75MP0000716_abnormal_immune_system1.16463909
76MP0000372_irregular_coat_pigmentation1.16061173
77MP0001984_abnormal_olfaction1.14300030
78MP0000689_abnormal_spleen_morphology1.13979714
79MP0002102_abnormal_ear_morphology1.13889826
80MP0001765_abnormal_ion_homeostasis1.12299925
81MP0003950_abnormal_plasma_membrane1.12033509
82MP0003303_peritoneal_inflammation1.10927628
83MP0002136_abnormal_kidney_physiology1.10213643
84MP0000465_gastrointestinal_hemorrhage1.10020559
85MP0000609_abnormal_liver_physiology1.09854543
86MP0005220_abnormal_exocrine_pancreas1.09274026
87MP0003879_abnormal_hair_cell1.07645344
88MP0003656_abnormal_erythrocyte_physiolo1.03942035
89MP0002396_abnormal_hematopoietic_system1.03677667
90MP0004381_abnormal_hair_follicle1.02365930
91MP0003283_abnormal_digestive_organ1.00794555
92MP0002398_abnormal_bone_marrow0.98966641
93MP0005464_abnormal_platelet_physiology0.97647968
94MP0002277_abnormal_respiratory_mucosa0.97603873
95MP0010155_abnormal_intestine_physiology0.95607765
96MP0002876_abnormal_thyroid_physiology0.95334783
97MP0005395_other_phenotype0.94910400
98MP0009764_decreased_sensitivity_to0.94895581
99MP0005646_abnormal_pituitary_gland0.93886892
100MP0003763_abnormal_thymus_physiology0.92455509
101MP0002118_abnormal_lipid_homeostasis0.90975681
102MP0003077_abnormal_cell_cycle0.90250507
103MP0005083_abnormal_biliary_tract0.89589847
104MP0008872_abnormal_physiological_respon0.89127774
105MP0004142_abnormal_muscle_tone0.88745434
106MP0002928_abnormal_bile_duct0.88435398
107MP0001756_abnormal_urination0.88281807
108MP0000371_diluted_coat_color0.88194225
109MP0004782_abnormal_surfactant_physiolog0.87427976
110MP0002163_abnormal_gland_morphology0.86800134
111MP0001968_abnormal_touch/_nociception0.86549033
112MP0001293_anophthalmia0.86367493
113MP0002722_abnormal_immune_system0.85447658
114MP0002693_abnormal_pancreas_physiology0.84946770
115MP0001533_abnormal_skeleton_physiology0.84848226
116MP0001929_abnormal_gametogenesis0.84694991
117MP0005647_abnormal_sex_gland0.84175753
118MP0005167_abnormal_blood-brain_barrier0.83347867
119MP0008004_abnormal_stomach_pH0.82845221
120MP0001661_extended_life_span0.81561175
121MP0001986_abnormal_taste_sensitivity0.80857186
122MP0008057_abnormal_DNA_replication0.80835941
123MP0004957_abnormal_blastocyst_morpholog0.80574694
124MP0009745_abnormal_behavioral_response0.79867670
125MP0003300_gastrointestinal_ulcer0.79782155
126MP0003866_abnormal_defecation0.78704469
127MP0005253_abnormal_eye_physiology0.77634827
128MP0002429_abnormal_blood_cell0.77323536
129MP0000230_abnormal_systemic_arterial0.76896620
130MP0005379_endocrine/exocrine_gland_phen0.76511610
131MP0006036_abnormal_mitochondrial_physio0.76282967
132MP0001119_abnormal_female_reproductive0.74577257
133MP0002272_abnormal_nervous_system0.73458823
134MP0010386_abnormal_urinary_bladder0.73335614
135MP0009046_muscle_twitch0.73035936
136MP0005584_abnormal_enzyme/coenzyme_acti0.72887654
137MP0000538_abnormal_urinary_bladder0.71463165
138MP0002132_abnormal_respiratory_system0.71108394
139MP0009765_abnormal_xenobiotic_induced0.71094230
140MP0002736_abnormal_nociception_after0.71040882
141MP0003698_abnormal_male_reproductive0.70989692
142MP0005389_reproductive_system_phenotype0.70838209
143MP0005266_abnormal_metabolism0.70524119
144MP0000579_abnormal_nail_morphology0.70021215
145MP0005174_abnormal_tail_pigmentation0.69400671
146MP0000598_abnormal_liver_morphology0.69132561
147MP0009763_increased_sensitivity_to0.68528759
148MP0009379_abnormal_foot_pigmentation0.67497887
149MP0006072_abnormal_retinal_apoptosis0.66466931
150MP0008260_abnormal_autophagy0.66378872
151MP0000427_abnormal_hair_cycle0.66370934
152MP0008469_abnormal_protein_level0.65426151
153MP0001324_abnormal_eye_pigmentation0.64655297
154MP0008995_early_reproductive_senescence0.64282272
155MP0005501_abnormal_skin_physiology0.64234268
156MP0001873_stomach_inflammation0.63084761
157MP0009642_abnormal_blood_homeostasis0.60950135
158MP0005084_abnormal_gallbladder_morpholo0.60741640
159MP0008007_abnormal_cellular_replicative0.60164109
160MP0002938_white_spotting0.57496481
161MP0005376_homeostasis/metabolism_phenot0.56160892
162MP0000383_abnormal_hair_follicle0.55963753
163MP0003638_abnormal_response/metabolism_0.55802195
164MP0000462_abnormal_digestive_system0.55241635
165MP0000477_abnormal_intestine_morphology0.54444685

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.50257075
2Abnormality of pyrimidine metabolism (HP:0004353)4.49926745
3Chromsome breakage (HP:0040012)4.06287103
4Stomatitis (HP:0010280)4.00776504
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.95585730
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.87551960
7Intrahepatic cholestasis (HP:0001406)3.87423031
8Hyperglycinuria (HP:0003108)3.79686745
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.52535193
10Congenital stationary night blindness (HP:0007642)3.46957412
11Optic neuritis (HP:0100653)3.43261078
12Retrobulbar optic neuritis (HP:0100654)3.43261078
13Proximal tubulopathy (HP:0000114)3.35375427
14Abnormality of nucleobase metabolism (HP:0010932)3.28326671
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24824562
16Reticulocytopenia (HP:0001896)3.23989326
17Generalized aminoaciduria (HP:0002909)3.23479653
18Abnormality of glycine metabolism (HP:0010895)3.17645895
19Abnormality of serine family amino acid metabolism (HP:0010894)3.17645895
20Pancreatic cysts (HP:0001737)3.05802413
21Hyperglycinemia (HP:0002154)3.02877988
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.01161267
23Myositis (HP:0100614)3.00810569
24Microvesicular hepatic steatosis (HP:0001414)2.99431075
25Attenuation of retinal blood vessels (HP:0007843)2.96344134
26Orchitis (HP:0100796)2.92520506
27Conjugated hyperbilirubinemia (HP:0002908)2.89327687
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88041216
29Abnormality of alanine metabolism (HP:0010916)2.88041216
30Hyperalaninemia (HP:0003348)2.88041216
31Hypomagnesemia (HP:0002917)2.87618527
32Hyperactive renin-angiotensin system (HP:0000841)2.87425990
33Abnormality of serum amino acid levels (HP:0003112)2.86070809
34Stomach cancer (HP:0012126)2.83085888
35Prolonged partial thromboplastin time (HP:0003645)2.80965991
36Gout (HP:0001997)2.80069326
37Increased circulating renin level (HP:0000848)2.76098333
38Hyperammonemia (HP:0001987)2.70268661
39Abnormality of macrophages (HP:0004311)2.69593747
40Keratoconjunctivitis (HP:0001096)2.69478083
41Abnormality of purine metabolism (HP:0004352)2.67526634
42True hermaphroditism (HP:0010459)2.64397748
43Congenital sensorineural hearing impairment (HP:0008527)2.60674833
44Abnormality of midbrain morphology (HP:0002418)2.59722302
45Molar tooth sign on MRI (HP:0002419)2.59722302
46Increased purine levels (HP:0004368)2.59572025
47Hyperuricemia (HP:0002149)2.59572025
48Polyuria (HP:0000103)2.55590075
49Renal cortical cysts (HP:0000803)2.55270975
50Delayed CNS myelination (HP:0002188)2.54721712
51Recurrent bacterial skin infections (HP:0005406)2.52232591
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.51739402
53Abnormality of the preputium (HP:0100587)2.50090038
54Abnormality of methionine metabolism (HP:0010901)2.49384215
55Gaze-evoked nystagmus (HP:0000640)2.48574055
56Abnormality of urine glucose concentration (HP:0011016)2.48282476
57Glycosuria (HP:0003076)2.48282476
58Abnormal urine output (HP:0012590)2.47765577
59Elevated erythrocyte sedimentation rate (HP:0003565)2.47084694
60Pancreatic fibrosis (HP:0100732)2.46708888
61Abolished electroretinogram (ERG) (HP:0000550)2.46626908
62Dicarboxylic aciduria (HP:0003215)2.46508764
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46508764
64Hypoglycemic coma (HP:0001325)2.46080833
65Chronic hepatic failure (HP:0100626)2.44600562
66Ketosis (HP:0001946)2.44599121
67Alkalosis (HP:0001948)2.42596206
68Duplicated collecting system (HP:0000081)2.41973973
69Abnormality of magnesium homeostasis (HP:0004921)2.39811911
70Joint hemorrhage (HP:0005261)2.38487849
71Hypobetalipoproteinemia (HP:0003563)2.36717954
72Recurrent abscess formation (HP:0002722)2.35476331
73Fat malabsorption (HP:0002630)2.35054268
74Widely patent fontanelles and sutures (HP:0004492)2.34859711
75Xanthomatosis (HP:0000991)2.34490357
76Prostate neoplasm (HP:0100787)2.34186369
77Abnormality of chromosome stability (HP:0003220)2.34101646
78Meckel diverticulum (HP:0002245)2.32893923
79Osteomalacia (HP:0002749)2.31597292
80Abnormality of the renal collecting system (HP:0004742)2.31489956
81Abnormality of renal excretion (HP:0011036)2.31265660
82Metabolic alkalosis (HP:0200114)2.31161951
83Decreased circulating renin level (HP:0003351)2.29956473
84Hypothermia (HP:0002045)2.28671295
85Recurrent fungal infections (HP:0002841)2.28587698
86Medial flaring of the eyebrow (HP:0010747)2.27863355
87Abnormal rod and cone electroretinograms (HP:0008323)2.27770425
88Nephronophthisis (HP:0000090)2.27281816
89Hypokalemic alkalosis (HP:0001949)2.25118264
90Nausea (HP:0002018)2.24475523
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.24374114
92Renal tubular acidosis (HP:0001947)2.24182425
93Recurrent cutaneous fungal infections (HP:0011370)2.23736448
94Chronic mucocutaneous candidiasis (HP:0002728)2.23736448
95Abnormality of fatty-acid metabolism (HP:0004359)2.23463420
96Rickets (HP:0002748)2.20517444
97Vacuolated lymphocytes (HP:0001922)2.20410640
98Abnormality of the ileum (HP:0001549)2.20149044
99Hemoptysis (HP:0002105)2.19535063
100Hematochezia (HP:0002573)2.19457017
101IgG deficiency (HP:0004315)2.18815986
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.18642106
103Albinism (HP:0001022)2.18270489
104Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18111525
105Thyroiditis (HP:0100646)2.17486791
106Abnormality of T cell number (HP:0011839)2.17380991
107Keratoconjunctivitis sicca (HP:0001097)2.17317721
108Distal lower limb muscle weakness (HP:0009053)2.15347520
109Abnormality of DNA repair (HP:0003254)2.14899397
110Bony spicule pigmentary retinopathy (HP:0007737)2.14794597
111Abnormality of macular pigmentation (HP:0008002)2.14731319
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.14517297
113Anal stenosis (HP:0002025)2.13935982
114Birth length less than 3rd percentile (HP:0003561)2.12959896
115Abnormality of chloride homeostasis (HP:0011422)2.11576749
116Abnormality of B cell number (HP:0010975)2.11301418
117Vasculitis (HP:0002633)2.09045794
118Abnormality of the prostate (HP:0008775)2.08932534
119Decreased central vision (HP:0007663)2.08288631
120Metabolic acidosis (HP:0001942)2.08247914
121Lethargy (HP:0001254)2.07689375
122Autoimmune thrombocytopenia (HP:0001973)2.07656620
123Constricted visual fields (HP:0001133)2.07105598
124Renal salt wasting (HP:0000127)2.07079449
125Vascular calcification (HP:0004934)2.05974123
126Reduced antithrombin III activity (HP:0001976)2.05552480
127Confusion (HP:0001289)2.04113670
128Increased IgM level (HP:0003496)2.02648785
129Tetany (HP:0001281)2.02438950
130Abnormality of liposaccharide metabolism (HP:0010968)2.02389375
131Abnormality of glycosphingolipid metabolism (HP:0004343)2.02389375
132Abnormality of glycolipid metabolism (HP:0010969)2.02389375
133Chronic diarrhea (HP:0002028)2.02203040
134Ketoacidosis (HP:0001993)2.01470598
135Aplasia/Hypoplasia of the fovea (HP:0008060)2.01226061
136Hypoplasia of the fovea (HP:0007750)2.01226061
137Encephalitis (HP:0002383)2.00758684
138Severe visual impairment (HP:0001141)1.99851237
139Dyschromatopsia (HP:0007641)1.99040885
140Increased cerebral lipofuscin (HP:0011813)1.98840360
141Abnormality of the renal medulla (HP:0100957)1.98752351
142Severe combined immunodeficiency (HP:0004430)1.97439285
143Pulmonary infiltrates (HP:0002113)1.96787490
144Type I transferrin isoform profile (HP:0003642)1.95858040
145Recurrent skin infections (HP:0001581)1.95378002
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95327828
147Abnormality of eosinophils (HP:0001879)1.95004725
148Gastrointestinal infarctions (HP:0005244)1.94666158
149Macular degeneration (HP:0000608)1.93342169
150Clubbing of toes (HP:0100760)1.92642881
151Leukocytosis (HP:0001974)1.91227781
152Hyperaldosteronism (HP:0000859)1.90565323
153Mediastinal lymphadenopathy (HP:0100721)1.90132923
154Pustule (HP:0200039)1.89580165
155Abnormality of the renal cortex (HP:0011035)1.88560799
156Steatorrhea (HP:0002570)1.88014408
157Abnormality of T cells (HP:0002843)1.86202641
158Opisthotonus (HP:0002179)1.85806646
159Abnormality of T cell physiology (HP:0011840)1.84295630
160Autoimmune hemolytic anemia (HP:0001890)1.84126949
161Abnormality of the fovea (HP:0000493)1.84121418
162Bile duct proliferation (HP:0001408)1.83958720
163Abnormal biliary tract physiology (HP:0012439)1.83958720
164Epidermoid cyst (HP:0200040)1.83290968
165Hyperventilation (HP:0002883)1.82379015
166Hyponatremia (HP:0002902)1.82112163
167Eczematoid dermatitis (HP:0000976)1.82104683
168Keratitis (HP:0000491)1.81164705
169Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81118105
170Enlarged kidneys (HP:0000105)1.80487471
171Polydipsia (HP:0001959)1.79008492
172Abnormal drinking behavior (HP:0030082)1.79008492
173Abnormal spermatogenesis (HP:0008669)1.77963273
174Nephrocalcinosis (HP:0000121)1.77841402
175Eosinophilia (HP:0001880)1.77777407
176Congenital hepatic fibrosis (HP:0002612)1.77242890
177T lymphocytopenia (HP:0005403)1.77236040
178Megaloblastic anemia (HP:0001889)1.76249494
179Breast hypoplasia (HP:0003187)1.76245464
180Renal tubular dysfunction (HP:0000124)1.76044177
181Combined immunodeficiency (HP:0005387)1.75202858
182Anorexia (HP:0002039)1.74264284
183Episodic fever (HP:0001954)1.72246667
184Photophobia (HP:0000613)1.71127562
185Progressive cerebellar ataxia (HP:0002073)1.68576894
186Polyneuropathy (HP:0001271)1.64613816
187Oligodactyly (hands) (HP:0001180)1.63176944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.59324945
2BCKDK3.45117538
3WNK33.16292500
4EPHA23.09096959
5STK163.05706425
6MAP4K22.94573430
7TNIK2.73471094
8EIF2AK22.51952850
9TTK2.42747335
10WEE12.15223344
11VRK12.11318563
12GRK12.10084947
13BUB12.08833892
14AKT31.99663552
15INSRR1.99604987
16PLK41.96787954
17NUAK11.92775918
18TLK11.91803873
19FLT31.90424254
20RPS6KB21.88858888
21IRAK31.88766053
22MAP3K131.81294463
23BMPR1B1.76770717
24STK38L1.72993606
25SRPK11.69242755
26TAOK31.66943578
27OXSR11.63537013
28TAOK21.60339186
29EIF2AK11.50984061
30TRIM281.44403104
31NEK11.43927702
32BMPR21.43205680
33EIF2AK31.42119420
34FRK1.34904022
35TEC1.30684193
36PASK1.30062631
37GRK61.27410655
38WNK41.27341405
39MUSK1.26001468
40FES1.24796195
41PLK11.24656285
42ATR1.17690563
43CDK71.17640486
44MAPK131.14580695
45CDK191.10741681
46NEK21.09993960
47PBK1.09611323
48STK241.08660103
49MAPKAPK31.07478074
50ITK1.07094434
51STK41.07074731
52DYRK31.06402785
53MAP2K61.04669166
54CSK1.03587243
55SYK0.98939211
56TYK20.97911713
57CAMKK20.97590970
58TGFBR20.95856955
59JAK10.95534207
60PIK3CG0.95251532
61AURKB0.93077786
62BRD40.91991779
63MAP3K40.91781119
64CHEK20.90032248
65NLK0.89355960
66CDK120.88143357
67GRK70.86985212
68BLK0.85284299
69MARK30.85158977
70MAP3K140.85127021
71ADRBK20.84049447
72STK390.83363637
73PRKCQ0.83302238
74IRAK10.81482909
75RIPK40.81187022
76SIK30.80636182
77MST40.80368572
78TRPM70.80096494
79MAPK150.79244066
80PRKCI0.76358516
81PDK20.75590734
82YES10.72907708
83TXK0.71185343
84NTRK30.71104118
85PTK2B0.70977290
86CDC70.69574064
87LCK0.69274302
88PRKAA20.68872533
89FER0.68545087
90AURKA0.68520819
91IKBKB0.68020496
92PLK30.65823411
93KIT0.65681368
94MAP3K120.65647562
95ERBB40.65250946
96IRAK40.64914414
97TGFBR10.64581659
98FGFR40.64348024
99NEK60.63947055
100MAPK110.63268077
101DAPK20.62378818
102IRAK20.62036448
103ACVR1B0.62035560
104ADRBK10.61720952
105MAP4K10.60070289
106BRSK20.59912896
107STK30.59888674
108FGR0.58264738
109PRKCE0.56229108
110TBK10.55813513
111KDR0.55557879
112BTK0.54298076
113PDK10.53393803
114MAP2K30.53179682
115JAK30.52988519
116HCK0.52719750
117MATK0.52606021
118AKT20.51176292
119PINK10.50881480
120LATS10.50264661
121RPS6KA50.50152209
122DYRK20.49222531
123PIK3CA0.46910014
124CHUK0.46025227
125JAK20.45329292
126ATM0.45086860
127PLK20.44258721
128PIM10.43946642
129SIK10.43112669
130ZAP700.42975127
131CDK40.41772391
132MAP3K80.41004309
133LYN0.40375928
134ABL10.40275410
135MAP3K110.39930960
136MAP3K30.39837332
137PKN10.38851225
138TIE10.38569155
139MAPK70.38424566
140CDK30.38127809
141TNK20.38100250
142CSNK2A10.37709765
143IKBKE0.36814554
144CSNK2A20.35690371
145CSF1R0.33995803
146NME20.33941919
147IGF1R0.32310567
148ERBB20.31241842
149ERBB30.31074573
150STK100.30825056
151MAP3K60.30215687

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68562746
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.60069409
3Tryptophan metabolism_Homo sapiens_hsa003802.50121547
4One carbon pool by folate_Homo sapiens_hsa006702.45738024
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.45301840
6Graft-versus-host disease_Homo sapiens_hsa053322.43760409
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.36369042
8Folate biosynthesis_Homo sapiens_hsa007902.29169224
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25950657
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24153242
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23648984
12Allograft rejection_Homo sapiens_hsa053302.20077418
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18081165
14Primary immunodeficiency_Homo sapiens_hsa053402.12367704
15Asthma_Homo sapiens_hsa053102.11533579
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11063729
17Autoimmune thyroid disease_Homo sapiens_hsa053202.08761531
18Peroxisome_Homo sapiens_hsa041462.01936832
19Fatty acid degradation_Homo sapiens_hsa000711.99272581
20Vitamin digestion and absorption_Homo sapiens_hsa049771.98889917
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.96935192
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89844365
23beta-Alanine metabolism_Homo sapiens_hsa004101.89833033
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.87723727
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87597807
26Type I diabetes mellitus_Homo sapiens_hsa049401.83514767
27Propanoate metabolism_Homo sapiens_hsa006401.82766911
28Mismatch repair_Homo sapiens_hsa034301.81693671
29Selenocompound metabolism_Homo sapiens_hsa004501.81433862
30Butanoate metabolism_Homo sapiens_hsa006501.77681931
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.77536766
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73321895
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70365081
34Retinol metabolism_Homo sapiens_hsa008301.68012387
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.67681078
36DNA replication_Homo sapiens_hsa030301.65252787
37Histidine metabolism_Homo sapiens_hsa003401.62367477
38Rheumatoid arthritis_Homo sapiens_hsa053231.61099217
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55615524
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54276789
41Fanconi anemia pathway_Homo sapiens_hsa034601.52363106
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52010545
43Leishmaniasis_Homo sapiens_hsa051401.51153991
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49390591
45Ether lipid metabolism_Homo sapiens_hsa005651.49223031
46Chemical carcinogenesis_Homo sapiens_hsa052041.44624350
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.40881751
48Homologous recombination_Homo sapiens_hsa034401.39948042
49Hematopoietic cell lineage_Homo sapiens_hsa046401.35806806
50Collecting duct acid secretion_Homo sapiens_hsa049661.35501293
51Osteoclast differentiation_Homo sapiens_hsa043801.34794796
52Arginine biosynthesis_Homo sapiens_hsa002201.34541329
53Fatty acid metabolism_Homo sapiens_hsa012121.34071774
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33942006
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31939416
56Olfactory transduction_Homo sapiens_hsa047401.30554615
57ABC transporters_Homo sapiens_hsa020101.30336609
58Base excision repair_Homo sapiens_hsa034101.29734490
59Glutathione metabolism_Homo sapiens_hsa004801.29346878
60Pyrimidine metabolism_Homo sapiens_hsa002401.28951483
61Caffeine metabolism_Homo sapiens_hsa002321.27175548
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27105502
63Fatty acid elongation_Homo sapiens_hsa000621.26356890
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26170320
65Arginine and proline metabolism_Homo sapiens_hsa003301.25687113
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25494868
67Pyruvate metabolism_Homo sapiens_hsa006201.25300199
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24746525
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24666531
70Tuberculosis_Homo sapiens_hsa051521.23804962
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23101457
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22441141
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.21616329
74Non-homologous end-joining_Homo sapiens_hsa034501.19417503
75Lysine degradation_Homo sapiens_hsa003101.17557707
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17466899
77Phenylalanine metabolism_Homo sapiens_hsa003601.16443504
78Dorso-ventral axis formation_Homo sapiens_hsa043201.15651122
79Phototransduction_Homo sapiens_hsa047441.14897469
80Ribosome_Homo sapiens_hsa030101.14525423
81Complement and coagulation cascades_Homo sapiens_hsa046101.12197720
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11101830
83Lysosome_Homo sapiens_hsa041421.09135413
84Legionellosis_Homo sapiens_hsa051341.08519298
85Antigen processing and presentation_Homo sapiens_hsa046121.08147027
86Ovarian steroidogenesis_Homo sapiens_hsa049131.07453221
87Steroid biosynthesis_Homo sapiens_hsa001001.07314303
88Nucleotide excision repair_Homo sapiens_hsa034201.05142344
89Biosynthesis of amino acids_Homo sapiens_hsa012301.04696223
90Glycosaminoglycan degradation_Homo sapiens_hsa005311.04569827
91RNA polymerase_Homo sapiens_hsa030201.01884935
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01844076
93Starch and sucrose metabolism_Homo sapiens_hsa005001.01647769
94Fat digestion and absorption_Homo sapiens_hsa049751.00386199
95T cell receptor signaling pathway_Homo sapiens_hsa046600.99817275
96Regulation of autophagy_Homo sapiens_hsa041400.99099673
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98707770
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97659653
99PPAR signaling pathway_Homo sapiens_hsa033200.97033930
100Bile secretion_Homo sapiens_hsa049760.96941685
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95288401
102Carbon metabolism_Homo sapiens_hsa012000.91211745
103Tyrosine metabolism_Homo sapiens_hsa003500.90864037
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90320140
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.89575601
106Linoleic acid metabolism_Homo sapiens_hsa005910.87208255
107Arachidonic acid metabolism_Homo sapiens_hsa005900.86928009
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84893944
109Serotonergic synapse_Homo sapiens_hsa047260.83415060
110Sulfur metabolism_Homo sapiens_hsa009200.83343107
111Nitrogen metabolism_Homo sapiens_hsa009100.80954171
112Measles_Homo sapiens_hsa051620.80737001
113Sphingolipid metabolism_Homo sapiens_hsa006000.80694125
114B cell receptor signaling pathway_Homo sapiens_hsa046620.80629464
115* Metabolic pathways_Homo sapiens_hsa011000.79385219
116Chemokine signaling pathway_Homo sapiens_hsa040620.78584519
117Pentose phosphate pathway_Homo sapiens_hsa000300.76003070
118Sulfur relay system_Homo sapiens_hsa041220.75580912
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72511891
120Other glycan degradation_Homo sapiens_hsa005110.72441196
121African trypanosomiasis_Homo sapiens_hsa051430.69445451
122Mineral absorption_Homo sapiens_hsa049780.68006638
123Purine metabolism_Homo sapiens_hsa002300.67568176
124Taste transduction_Homo sapiens_hsa047420.65778030
125Systemic lupus erythematosus_Homo sapiens_hsa053220.65735851
126Pertussis_Homo sapiens_hsa051330.65175784
127Fructose and mannose metabolism_Homo sapiens_hsa000510.64341807
128TNF signaling pathway_Homo sapiens_hsa046680.64151537
129Oxidative phosphorylation_Homo sapiens_hsa001900.62163572
130Renin-angiotensin system_Homo sapiens_hsa046140.61048501
131Phagosome_Homo sapiens_hsa041450.60540480
132Salivary secretion_Homo sapiens_hsa049700.60514874
133Malaria_Homo sapiens_hsa051440.60199466
134Herpes simplex infection_Homo sapiens_hsa051680.58600722
135Morphine addiction_Homo sapiens_hsa050320.57907619
136Glycerolipid metabolism_Homo sapiens_hsa005610.56895359
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56627942
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56237987
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.55749590
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55571975
141Vitamin B6 metabolism_Homo sapiens_hsa007500.55560223
142Nicotine addiction_Homo sapiens_hsa050330.55421705
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54776887
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54049017
145Proteasome_Homo sapiens_hsa030500.53632196
146Platelet activation_Homo sapiens_hsa046110.53432642
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53140859
148Circadian rhythm_Homo sapiens_hsa047100.52831886
149Staphylococcus aureus infection_Homo sapiens_hsa051500.52601657
150Protein export_Homo sapiens_hsa030600.51424822
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50685913
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50310947
153Basal transcription factors_Homo sapiens_hsa030220.49645016
154Influenza A_Homo sapiens_hsa051640.48592096
155p53 signaling pathway_Homo sapiens_hsa041150.47967292
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46995677
157Toxoplasmosis_Homo sapiens_hsa051450.45173805
158Protein digestion and absorption_Homo sapiens_hsa049740.42278229
159Galactose metabolism_Homo sapiens_hsa000520.39297068
160Cell cycle_Homo sapiens_hsa041100.30360798
161Spliceosome_Homo sapiens_hsa030400.29858433
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29656268
163RNA degradation_Homo sapiens_hsa030180.29366078
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28055066
165Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19237279

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