TPM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)8.55744293
2* muscle filament sliding (GO:0030049)8.35155587
3* actin-myosin filament sliding (GO:0033275)8.35155587
4cardiac myofibril assembly (GO:0055003)7.92074009
5myofibril assembly (GO:0030239)7.30058515
6* actin-mediated cell contraction (GO:0070252)7.07847605
7plasma membrane repair (GO:0001778)6.82377307
8regulation of skeletal muscle contraction (GO:0014819)6.78905865
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.45870053
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.28740273
11cardiac muscle cell development (GO:0055013)5.94840795
12* actomyosin structure organization (GO:0031032)5.90137146
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.70369482
14* cardiac muscle contraction (GO:0060048)5.65261130
15cardiac cell development (GO:0055006)5.61223373
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.54674781
17* actin filament-based movement (GO:0030048)5.41741163
18* cardiac muscle tissue morphogenesis (GO:0055008)5.14601818
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.09032614
20regulation of relaxation of muscle (GO:1901077)4.99302489
21* striated muscle contraction (GO:0006941)4.92912827
22regulation of actin filament-based movement (GO:1903115)4.84823170
23tricarboxylic acid cycle (GO:0006099)4.81380255
24* muscle tissue morphogenesis (GO:0060415)4.73992088
25adult heart development (GO:0007512)4.72408545
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.71039802
27cardiac muscle hypertrophy (GO:0003300)4.64145123
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.63390813
29sarcoplasmic reticulum calcium ion transport (GO:0070296)4.62410191
30heart trabecula formation (GO:0060347)4.61185797
31* ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.60258269
32ventricular cardiac muscle cell action potential (GO:0086005)4.51317410
33striated muscle hypertrophy (GO:0014897)4.45156855
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.42249017
35heart contraction (GO:0060047)4.39881549
36heart process (GO:0003015)4.39881549
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.39432352
38regulation of cell communication by electrical coupling (GO:0010649)4.29305559
39regulation of striated muscle contraction (GO:0006942)4.25828951
40negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.19415487
41regulation of cardioblast differentiation (GO:0051890)4.17279590
42regulation of sarcomere organization (GO:0060297)4.17249888
43carnitine shuttle (GO:0006853)4.08342726
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.98783254
45skeletal muscle contraction (GO:0003009)3.97485577
46regulation of the force of heart contraction (GO:0002026)3.94866268
47negative regulation of striated muscle cell apoptotic process (GO:0010664)3.88682219
48muscle hypertrophy (GO:0014896)3.88548692
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.85214622
50* muscle contraction (GO:0006936)3.83072806
51striated muscle cell development (GO:0055002)3.74559471
52ventricular cardiac muscle cell development (GO:0055015)3.72715146
53regulation of membrane repolarization (GO:0060306)3.56867520
54epithelial cell-cell adhesion (GO:0090136)3.55509720
55endodermal cell differentiation (GO:0035987)3.55436978
56collagen fibril organization (GO:0030199)3.55101261
57regulation of acyl-CoA biosynthetic process (GO:0050812)3.55017343
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54266512
59* muscle system process (GO:0003012)3.50350922
60trabecula formation (GO:0060343)3.48889915
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.48259441
62cell communication involved in cardiac conduction (GO:0086065)3.45216344
63regulation of cardiac muscle cell apoptotic process (GO:0010665)3.42902625
64paraxial mesoderm development (GO:0048339)3.39384786
65regulation of cofactor metabolic process (GO:0051193)3.38102464
66regulation of coenzyme metabolic process (GO:0051196)3.38102464
67desmosome organization (GO:0002934)3.36120460
68fatty acid transmembrane transport (GO:1902001)3.35334399
69response to inactivity (GO:0014854)3.32159308
70bone trabecula formation (GO:0060346)3.29700640
71cardiac muscle adaptation (GO:0014887)3.29453215
72cardiac muscle hypertrophy in response to stress (GO:0014898)3.29453215
73muscle hypertrophy in response to stress (GO:0003299)3.29453215
74skeletal muscle adaptation (GO:0043501)3.28375201
75muscle cell development (GO:0055001)3.26039097
76cardiac muscle cell action potential involved in contraction (GO:0086002)3.24825785
77cell migration involved in heart development (GO:0060973)3.22095975
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21968106
79cardiac muscle cell action potential (GO:0086001)3.21773478
80atrial septum morphogenesis (GO:0060413)3.19963334
81negative regulation of protein localization to cell surface (GO:2000009)3.18861801
82regulation of tight junction assembly (GO:2000810)3.18180432
83striated muscle adaptation (GO:0014888)3.17874675
84positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16406049
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16172020
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15752004
87atrioventricular valve morphogenesis (GO:0003181)3.15659213
88cell communication by electrical coupling (GO:0010644)3.15393873
89* regulation of muscle contraction (GO:0006937)3.15311719
90regulation of cardiac muscle contraction (GO:0055117)3.15234001
91* regulation of ATP catabolic process (GO:1903289)3.15051160
92* regulation of ATPase activity (GO:0043462)3.15051160
93regulation of transforming growth factor beta2 production (GO:0032909)3.14232564
94notochord development (GO:0030903)3.13476490
95muscle fiber development (GO:0048747)3.13222083
96cardiac chamber formation (GO:0003207)3.12185957
97regulation of striated muscle cell apoptotic process (GO:0010662)3.09494947
98gap junction assembly (GO:0016264)3.08246931
99actin filament depolymerization (GO:0030042)3.07239811
100negative regulation of potassium ion transport (GO:0043267)3.06836704
101outflow tract septum morphogenesis (GO:0003148)3.03675547
102* regulation of heart rate (GO:0002027)3.03564654
103chondrocyte proliferation (GO:0035988)3.00311065
104negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00240847
105creatine metabolic process (GO:0006600)2.99264299
106sequestering of extracellular ligand from receptor (GO:0035581)2.96559162
107negative regulation of cardiac muscle tissue growth (GO:0055022)2.94971406
108negative regulation of heart growth (GO:0061117)2.94971406
109protein hydroxylation (GO:0018126)2.94614848
110* regulation of heart contraction (GO:0008016)2.90769536
111endocardial cushion development (GO:0003197)2.90689866
112positive regulation of cardiac muscle cell differentiation (GO:2000727)2.89051473
113* regulation of muscle system process (GO:0090257)2.88854769
114positive regulation of cardiac muscle tissue development (GO:0055025)2.88683649
115negative regulation of chondrocyte differentiation (GO:0032331)2.87619775
116adherens junction assembly (GO:0034333)2.86180386
117cell-substrate adherens junction assembly (GO:0007045)2.85190197
118focal adhesion assembly (GO:0048041)2.85190197
119carnitine transmembrane transport (GO:1902603)2.85131747
120ATP synthesis coupled proton transport (GO:0015986)2.84871709
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84871709
122regulation of cardiac muscle cell contraction (GO:0086004)2.81538545
123cell-substrate junction assembly (GO:0007044)2.81002451
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79678677
125positive regulation of catenin import into nucleus (GO:0035413)2.78097180
126convergent extension (GO:0060026)2.76741735
127hippo signaling (GO:0035329)2.73823059
128cardiac ventricle formation (GO:0003211)2.72409524
129regulation of cardiac muscle tissue development (GO:0055024)2.72270956
130substrate adhesion-dependent cell spreading (GO:0034446)2.68459695
131retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68290808
132regulation of cardiac muscle cell differentiation (GO:2000725)2.67236915
133lymphangiogenesis (GO:0001946)2.67085061
134positive regulation of cardiac muscle cell proliferation (GO:0060045)2.66781513
135regulation of establishment of planar polarity (GO:0090175)2.66657029
136cell adhesion mediated by integrin (GO:0033627)2.62970808
137kidney mesenchyme development (GO:0072074)2.62671133
138cell migration involved in sprouting angiogenesis (GO:0002042)2.60247051
139muscle cell fate commitment (GO:0042693)2.56728209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse4.62957027
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59055615
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.51649719
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.51620061
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.79806261
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.34266219
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.34266219
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.24515170
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.17947797
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.06462021
11CLOCK_20551151_ChIP-Seq_293T_Human2.83238497
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.81513431
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.54825961
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43645115
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.41813250
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.38922904
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.37089084
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33091110
19ZNF263_19887448_ChIP-Seq_K562_Human2.31826219
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27595439
21GATA4_21415370_ChIP-Seq_HL-1_Mouse2.23661716
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16778705
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13250183
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.02771319
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.01061776
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83384830
27* CJUN_26792858_Chip-Seq_BT549_Human1.81118649
28TP53_18474530_ChIP-ChIP_U2OS_Human1.81045451
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75863668
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74628740
31ATF3_27146783_Chip-Seq_COLON_Human1.70720675
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.68249673
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.66709848
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66669915
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.64879498
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64799575
37* EED_16625203_ChIP-ChIP_MESCs_Mouse1.63139500
38* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60851321
39* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60851321
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59093466
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.58567938
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56899389
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56815311
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56212622
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55778626
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51049641
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51049641
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49774521
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47836338
50* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47711051
51RACK7_27058665_Chip-Seq_MCF-7_Human1.41712269
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40720757
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.40217520
54BRD4_25478319_ChIP-Seq_HGPS_Human1.39534651
55* ISL1_27105846_Chip-Seq_CPCs_Mouse1.37676815
56* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37378632
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37231309
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34701990
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34667270
60* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34618696
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32378299
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31482593
63* EZH2_27304074_Chip-Seq_ESCs_Mouse1.30864476
64SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30416735
65TP53_23651856_ChIP-Seq_MEFs_Mouse1.30166958
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29573117
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28413049
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28092881
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27834490
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27447367
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26951762
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24935634
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23244668
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23060027
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22563462
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21327757
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.20867155
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20292130
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19966462
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19800125
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19766472
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19410286
83TP53_22127205_ChIP-Seq_IMR90_Human1.18857432
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17599052
85* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16502912
86GBX2_23144817_ChIP-Seq_PC3_Human1.15904699
87* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15588121
88* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15547400
89* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15473871
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.13098433
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12732235
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12640716
93AR_21909140_ChIP-Seq_LNCAP_Human1.11489770
94* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11257360
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11257360
96* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11119377
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11056997
98* SMAD3_21741376_ChIP-Seq_HESCs_Human1.10810405
99* TP53_20018659_ChIP-ChIP_R1E_Mouse1.10663117
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10049452
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.09665035
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08320696
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07602341
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06810316
105ZNF274_21170338_ChIP-Seq_K562_Hela1.06672459
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06393057
107* KDM2B_26808549_Chip-Seq_DND41_Human1.06167291
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05086565
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03541533
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03483626
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03442300
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03357571
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.03236982
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03093326
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02736940
116* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02691361
117* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02637470
118SA1_22415368_ChIP-Seq_MEFs_Mouse1.02600847
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01544839
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00706381
121AHR_22903824_ChIP-Seq_MCF-7_Human0.99833929
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98255982
123TP53_16413492_ChIP-PET_HCT116_Human0.96815115
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96797358
125* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96275409
126EZH2_22144423_ChIP-Seq_EOC_Human0.95899910
127* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95837277
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95717763
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.95381280
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95202718
131SMAD4_21799915_ChIP-Seq_A2780_Human0.93804159
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93320636
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93287928
134* RING1B_27294783_Chip-Seq_ESCs_Mouse0.91841575
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.91550906
136* TP63_22573176_ChIP-Seq_HFKS_Human0.91469529
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90861397
138LXR_22292898_ChIP-Seq_THP-1_Human0.90765485
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90437465
140SOX2_20726797_ChIP-Seq_SW620_Human0.89450962
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88012399
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87400065
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.81954435
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81496149
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79427741
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78523548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.23261339
2MP0004084_abnormal_cardiac_muscle5.03444892
3MP0000751_myopathy4.56858387
4MP0000749_muscle_degeneration4.25856570
5MP0003646_muscle_fatigue4.05861154
6MP0004036_abnormal_muscle_relaxation3.93105725
7MP0004215_abnormal_myocardial_fiber3.48849924
8MP0005330_cardiomyopathy3.36207419
9MP0004087_abnormal_muscle_fiber3.09157549
10MP0000750_abnormal_muscle_regeneration2.91766707
11MP0004145_abnormal_muscle_electrophysio2.89585590
12MP0008438_abnormal_cutaneous_collagen2.81205037
13MP0002972_abnormal_cardiac_muscle2.78935175
14MP0005620_abnormal_muscle_contractility2.74414889
15MP0002106_abnormal_muscle_physiology2.52620592
16MP0008775_abnormal_heart_ventricle2.50052661
17MP0010630_abnormal_cardiac_muscle2.40622113
18MP0002269_muscular_atrophy2.38854533
19MP0000747_muscle_weakness2.27423775
20MP0006138_congestive_heart_failure2.24480071
21MP0001544_abnormal_cardiovascular_syste2.23143356
22MP0005385_cardiovascular_system_phenoty2.23143356
23MP0000759_abnormal_skeletal_muscle2.22988038
24MP0003705_abnormal_hypodermis_morpholog2.21501164
25MP0003137_abnormal_impulse_conducting2.19232963
26MP0005369_muscle_phenotype2.14895028
27MP0005275_abnormal_skin_tensile2.11286878
28MP0003279_aneurysm2.07890906
29MP0004484_altered_response_of2.03970411
30MP0004233_abnormal_muscle_weight1.98179196
31MP0004130_abnormal_muscle_cell1.95240604
32MP0003828_pulmonary_edema1.85867613
33MP0005623_abnormal_meninges_morphology1.76076445
34MP0003950_abnormal_plasma_membrane1.75972522
35MP0003566_abnormal_cell_adhesion1.68576559
36MP0005503_abnormal_tendon_morphology1.66093803
37MP0003221_abnormal_cardiomyocyte_apopto1.64630197
38MP0004272_abnormal_basement_membrane1.61595008
39MP0004085_abnormal_heartbeat1.60693027
40MP0000733_abnormal_muscle_development1.46571625
41MP0002127_abnormal_cardiovascular_syste1.42616975
42MP0009384_cardiac_valve_regurgitation1.40136372
43MP0009379_abnormal_foot_pigmentation1.32880116
44MP0003567_abnormal_fetal_cardiomyocyte1.29658940
45MP0002108_abnormal_muscle_morphology1.29069518
46MP0003937_abnormal_limbs/digits/tail_de1.28663855
47MP0004510_myositis1.28397732
48MP0003942_abnormal_urinary_system1.27874262
49MP0010368_abnormal_lymphatic_system1.23312553
50MP0002332_abnormal_exercise_endurance1.22522358
51MP0000266_abnormal_heart_morphology1.18346638
52MP0003755_abnormal_palate_morphology1.13491330
53MP0002234_abnormal_pharynx_morphology1.10423042
54MP0001958_emphysema1.09844609
55MP0005666_abnormal_adipose_tissue1.09526964
56MP0000013_abnormal_adipose_tissue1.09459780
57MP0002697_abnormal_eye_size1.08462016
58MP0002233_abnormal_nose_morphology1.08311659
59MP0000767_abnormal_smooth_muscle1.02213769
60MP0005248_abnormal_Harderian_gland1.00617020
61MP0003941_abnormal_skin_development0.99331550
62MP0002128_abnormal_blood_circulation0.98431334
63MP0006036_abnormal_mitochondrial_physio0.97394650
64MP0000462_abnormal_digestive_system0.96758126
65MP0000343_altered_response_to0.94868870
66MP0000049_abnormal_middle_ear0.94791249
67MP0003385_abnormal_body_wall0.93170558
68MP0004185_abnormal_adipocyte_glucose0.91915681
69MP0010352_gastrointestinal_tract_polyps0.91575260
70MP0001542_abnormal_bone_strength0.89868845
71MP0005375_adipose_tissue_phenotype0.88559220
72MP0001293_anophthalmia0.87904652
73MP0004858_abnormal_nervous_system0.87253859
74MP0005165_increased_susceptibility_to0.84786787
75MP0000432_abnormal_head_morphology0.84311232
76MP0005197_abnormal_uvea_morphology0.82929174
77MP0003091_abnormal_cell_migration0.81750900
78MP0010030_abnormal_orbit_morphology0.80912636
79MP0001879_abnormal_lymphatic_vessel0.79352658
80MP0005023_abnormal_wound_healing0.76960223
81MP0002925_abnormal_cardiovascular_devel0.76548218
82MP0006054_spinal_hemorrhage0.75869184
83MP0001661_extended_life_span0.75800805
84MP0001299_abnormal_eye_distance/0.74523027
85MP0001286_abnormal_eye_development0.74387467
86MP0000003_abnormal_adipose_tissue0.74094365
87MP0005670_abnormal_white_adipose0.73763272
88MP0002116_abnormal_craniofacial_bone0.72718759
89MP0009250_abnormal_appendicular_skeleto0.72556782
90MP0002295_abnormal_pulmonary_circulatio0.69520202
91MP0000163_abnormal_cartilage_morphology0.69411315
92MP0004134_abnormal_chest_morphology0.67484414
93MP0002092_abnormal_eye_morphology0.67404900
94MP0002114_abnormal_axial_skeleton0.65793191
95MP0001614_abnormal_blood_vessel0.65559851
96MP0005193_abnormal_anterior_eye0.65246637
97MP0002877_abnormal_melanocyte_morpholog0.63797074
98MP0000579_abnormal_nail_morphology0.61908176
99MP0000230_abnormal_systemic_arterial0.61176921
100MP0003984_embryonic_growth_retardation0.61023807
101MP0003283_abnormal_digestive_organ0.60995684
102MP0002088_abnormal_embryonic_growth/wei0.60297820
103MP0002896_abnormal_bone_mineralization0.60163695
104MP0005508_abnormal_skeleton_morphology0.59840834
105MP0000537_abnormal_urethra_morphology0.55511075
106MP0000762_abnormal_tongue_morphology0.55237014
107MP0003045_fibrosis0.54568432
108MP0005266_abnormal_metabolism0.53250052
109MP0006035_abnormal_mitochondrial_morpho0.51602046
110MP0001784_abnormal_fluid_regulation0.51389321
111MP0002060_abnormal_skin_morphology0.51364209
112MP0009053_abnormal_anal_canal0.51300215
113MP0000428_abnormal_craniofacial_morphol0.51095599
114MP0000534_abnormal_ureter_morphology0.48596985
115MP0005595_abnormal_vascular_smooth0.48136856
116MP0005187_abnormal_penis_morphology0.47336721
117MP0003115_abnormal_respiratory_system0.45365270
118MP0003935_abnormal_craniofacial_develop0.45241904
119MP0005257_abnormal_intraocular_pressure0.45161437
120MP0009780_abnormal_chondrocyte_physiolo0.41787398
121MP0001672_abnormal_embryogenesis/_devel0.40538910
122MP0005380_embryogenesis_phenotype0.40538910
123MP0003806_abnormal_nucleotide_metabolis0.39182920
124MP0000516_abnormal_urinary_system0.39051883

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.61163771
2Exercise-induced muscle cramps (HP:0003710)6.29260570
3Exercise-induced myalgia (HP:0003738)5.84240920
4Calf muscle hypertrophy (HP:0008981)5.77486952
5Muscle fiber splitting (HP:0003555)5.56957334
6Muscle hypertrophy of the lower extremities (HP:0008968)5.51939853
7Hyporeflexia of lower limbs (HP:0002600)5.16484358
8Abnormality of the calf musculature (HP:0001430)5.05797548
9* Ventricular tachycardia (HP:0004756)4.96147710
10Right ventricular cardiomyopathy (HP:0011663)4.86336848
11Type 1 muscle fiber predominance (HP:0003803)4.72697955
12Atrial fibrillation (HP:0005110)4.71400806
13Increased connective tissue (HP:0009025)4.70692077
14Subaortic stenosis (HP:0001682)4.65980431
15Abnormality of the left ventricular outflow tract (HP:0011103)4.65980431
16* Lipoatrophy (HP:0100578)4.44124231
17Primary atrial arrhythmia (HP:0001692)4.41034139
18EMG: myopathic abnormalities (HP:0003458)4.39120631
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.33042663
20Muscle fiber inclusion bodies (HP:0100299)4.27146836
21Myoglobinuria (HP:0002913)4.25600796
22Supraventricular tachycardia (HP:0004755)4.24773110
23Supraventricular arrhythmia (HP:0005115)4.21509944
24Difficulty running (HP:0009046)3.76429441
25Nemaline bodies (HP:0003798)3.68503701
26Asymmetric septal hypertrophy (HP:0001670)3.53278235
27Difficulty climbing stairs (HP:0003551)3.50498126
28* Dilated cardiomyopathy (HP:0001644)3.50461017
29Myotonia (HP:0002486)3.47591737
30Rhabdomyolysis (HP:0003201)3.44150085
31Palpitations (HP:0001962)3.31900494
32Protrusio acetabuli (HP:0003179)3.31803966
33Syncope (HP:0001279)3.31001043
34Ventricular arrhythmia (HP:0004308)3.28200815
35Round ear (HP:0100830)3.28141370
36Bundle branch block (HP:0011710)3.26497342
37Prolonged QT interval (HP:0001657)3.24278526
38Arterial tortuosity (HP:0005116)3.20274005
39Vascular tortuosity (HP:0004948)3.18981626
40Premature rupture of membranes (HP:0001788)3.17648692
41Increased variability in muscle fiber diameter (HP:0003557)3.13042934
42Distal arthrogryposis (HP:0005684)3.09585947
43Distal lower limb muscle weakness (HP:0009053)3.08005289
44Abnormality of skeletal muscle fiber size (HP:0012084)3.05825034
45Cervical subluxation (HP:0003308)2.93130178
46Neck muscle weakness (HP:0000467)2.87339286
47Mildly elevated creatine phosphokinase (HP:0008180)2.84899877
48Abnormal atrioventricular conduction (HP:0005150)2.80701155
49Heart block (HP:0012722)2.76647562
50Muscle stiffness (HP:0003552)2.76015998
51Scapular winging (HP:0003691)2.74113740
52Atrioventricular block (HP:0001678)2.67056399
53Spinal rigidity (HP:0003306)2.64461791
54Mitral valve prolapse (HP:0001634)2.58092872
55Myopathic facies (HP:0002058)2.55977975
56Limited hip movement (HP:0008800)2.55023355
57Limb-girdle muscle atrophy (HP:0003797)2.51055924
58Neonatal short-limb short stature (HP:0008921)2.47422913
59Aortic aneurysm (HP:0004942)2.44590147
60Ventricular fibrillation (HP:0001663)2.43891569
61Broad metatarsal (HP:0001783)2.42764511
62Areflexia of lower limbs (HP:0002522)2.42688660
63Aortic dissection (HP:0002647)2.40374487
64Distal lower limb amyotrophy (HP:0008944)2.39984141
65Cerebral aneurysm (HP:0004944)2.38676441
66Bladder diverticulum (HP:0000015)2.33213155
67Ulnar deviation of the wrist (HP:0003049)2.31577183
68Rimmed vacuoles (HP:0003805)2.31485855
69Muscular dystrophy (HP:0003560)2.22493197
70Abnormal EKG (HP:0003115)2.21391049
71Ankle contracture (HP:0006466)2.19822659
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.17359091
73Calcaneovalgus deformity (HP:0001848)2.17067306
74Generalized muscle weakness (HP:0003324)2.15391268
75Abnormality of dentin (HP:0010299)2.14459659
76Hypoplastic ischia (HP:0003175)2.12761465
77Wide anterior fontanel (HP:0000260)2.06038405
78Left ventricular hypertrophy (HP:0001712)2.05931820
79Abnormality of the foot musculature (HP:0001436)2.05469306
80* Palmoplantar keratoderma (HP:0000982)2.04842535
81Absent phalangeal crease (HP:0006109)2.03530010
82Facial diplegia (HP:0001349)2.03371441
83Mitral regurgitation (HP:0001653)2.01815305
84Deformed tarsal bones (HP:0008119)2.00442498
85EMG: neuropathic changes (HP:0003445)1.98958818
86Conjunctival hamartoma (HP:0100780)1.96269832
87Gowers sign (HP:0003391)1.96181496
88Shallow orbits (HP:0000586)1.95827662
89Vitreoretinal degeneration (HP:0000655)1.95028671
90Foot dorsiflexor weakness (HP:0009027)1.94786369
91Limb-girdle muscle weakness (HP:0003325)1.93982829
92Partial duplication of thumb phalanx (HP:0009944)1.92964986
93Hip contracture (HP:0003273)1.92578188
94Coronal craniosynostosis (HP:0004440)1.92488507
95Infantile muscular hypotonia (HP:0008947)1.92282363
96Abnormality of the shoulder girdle musculature (HP:0001435)1.91719934
97Overgrowth (HP:0001548)1.91291273
98Partial duplication of the phalanx of hand (HP:0009999)1.91258731
99Wrist flexion contracture (HP:0001239)1.91042973
100Wormian bones (HP:0002645)1.89205375
101Ectopia lentis (HP:0001083)1.86895127
102Frequent falls (HP:0002359)1.86440178
103Abnormality of the calcaneus (HP:0008364)1.85713350
104Blue sclerae (HP:0000592)1.84906368
105Lower limb amyotrophy (HP:0007210)1.84114003
106Atrophic scars (HP:0001075)1.83993583
107Genu recurvatum (HP:0002816)1.81935051
108Thin ribs (HP:0000883)1.81526420
109Aneurysm (HP:0002617)1.81483598
110Abnormality of the ischium (HP:0003174)1.81395989
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79514711
112Fragile skin (HP:0001030)1.78094595
113Pulmonary artery stenosis (HP:0004415)1.78038502
114Bowel diverticulosis (HP:0005222)1.73916854
115Mesomelia (HP:0003027)1.72588941
116Abnormality of the tricuspid valve (HP:0001702)1.71935442
117Aortic regurgitation (HP:0001659)1.71293045
118Slender build (HP:0001533)1.70851050
119Ulnar bowing (HP:0003031)1.70778783
120Disproportionate tall stature (HP:0001519)1.70711948
121Pterygium (HP:0001059)1.70681134
122Sudden cardiac death (HP:0001645)1.68215488
123* Congestive heart failure (HP:0001635)1.67851196
124Patent foramen ovale (HP:0001655)1.65871390
125Ragged-red muscle fibers (HP:0003200)1.64248696
126Proximal amyotrophy (HP:0007126)1.62776920
127Testicular atrophy (HP:0000029)1.59203194
128Increased density of long bones (HP:0006392)1.58698438
129Dilatation of the ascending aorta (HP:0005111)1.58436895
130Abnormal finger flexion creases (HP:0006143)1.58356096
131Soft skin (HP:0000977)1.53414204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.82070283
2OBSCN5.09229886
3MYLK4.24630900
4PHKG23.30095588
5PHKG13.30095588
6DMPK3.11155715
7TRIB33.10505118
8PKN22.91892393
9LMTK22.57725885
10PDK32.39019065
11PDK42.39019065
12NEK12.24978154
13PAK31.75153278
14STK241.73826179
15LIMK11.59434857
16ILK1.54756578
17ZAK1.52499692
18PDK21.50175911
19TRPM71.50153032
20PIK3CG1.48957282
21PDGFRA1.48671281
22STK38L1.42563943
23RIPK11.37469843
24TESK11.35185457
25LATS21.34955187
26ROCK11.31657179
27LATS11.29083169
28MAP2K31.26375405
29MAPKAPK31.26031966
30CDC42BPA1.21333765
31BCKDK1.20938897
32MUSK1.18690903
33DDR21.18669121
34NTRK11.16123373
35PAK21.15029245
36TIE11.09169590
37DAPK31.08498027
38EPHB21.05972369
39PTK2B1.02310125
40PRKD11.01573134
41MAP3K30.95953497
42CAMK2D0.90846487
43MAP3K70.88581110
44FER0.85930703
45MAP3K50.84567190
46NME10.83492946
47NEK90.77500518
48PTK60.77409958
49AKT30.76906935
50PINK10.76092226
51LRRK20.75358490
52ROCK20.74018056
53MAPK120.73618408
54EPHA20.71382887
55FLT30.69342189
56STK390.69107733
57PTK20.68640742
58SIK10.66162158
59MAP3K120.65377319
60DYRK1B0.63710278
61TNIK0.63672477
62MELK0.63591004
63KDR0.60282305
64MAPK70.58632061
65CAMK1G0.58179661
66PLK40.57518599
67ARAF0.56097173
68ERBB40.55965782
69PRKAA20.55746390
70MAP3K60.55468046
71PRKAA10.55342539
72FGFR10.53480976
73STK40.52719451
74CAMK2B0.51184048
75PRKD20.50969135
76TGFBR20.49684839
77MTOR0.49600049
78PRKG20.48818734
79GRK70.48736611
80STK380.45687645
81MAP2K10.45408761
82STK30.44190114
83MET0.40041698
84PAK40.39711255
85AKT20.39380418
86MAP3K100.38018919
87CAMK2G0.37801393
88RPS6KC10.37258217
89RPS6KL10.37258217
90PRKACB0.37231623
91WNK10.37179939
92WNK40.37073997
93ERBB30.36960669
94BCR0.35368741
95RPS6KB20.34578233
96NME20.33928837
97PRKD30.33088064
98ADRBK10.31732093
99BMX0.31265423
100KSR10.30783393
101MAP3K110.30348703
102FGFR20.30132127
103TAOK10.30008443
104PDGFRB0.29560085
105CAMK10.29513377
106CAMK2A0.28655877
107RPS6KA60.28639193
108MARK10.28035768
109AURKB0.27898262
110MAP2K60.26092854
111EPHB10.25695331
112PRKCE0.23054951
113CAMK40.22547320
114MOS0.22158341
115RET0.22029632
116TGFBR10.21943098
117EEF2K0.21797881
118MAPKAPK20.21670323
119TAOK20.20591285
120PAK10.19305590
121ERN10.19150591
122RPS6KA20.18899273
123MAP3K80.16314846

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.12715278
2* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.60909784
3* Dilated cardiomyopathy_Homo sapiens_hsa054144.43392321
4* Cardiac muscle contraction_Homo sapiens_hsa042604.14843668
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.52680745
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.51047217
7Parkinsons disease_Homo sapiens_hsa050122.46286868
8Oxidative phosphorylation_Homo sapiens_hsa001902.14660168
9Carbon metabolism_Homo sapiens_hsa012002.10166688
10Viral myocarditis_Homo sapiens_hsa054162.10067133
11Focal adhesion_Homo sapiens_hsa045102.04177395
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02539998
13Propanoate metabolism_Homo sapiens_hsa006401.95100942
14ECM-receptor interaction_Homo sapiens_hsa045121.83581140
15* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83492485
16Alzheimers disease_Homo sapiens_hsa050101.79692183
17Fatty acid degradation_Homo sapiens_hsa000711.70839703
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63297604
19Tight junction_Homo sapiens_hsa045301.58720561
20Adherens junction_Homo sapiens_hsa045201.50075405
21Huntingtons disease_Homo sapiens_hsa050161.49642500
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45405099
23Proteoglycans in cancer_Homo sapiens_hsa052051.28384132
24Pyruvate metabolism_Homo sapiens_hsa006201.22439830
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22233405
26Glucagon signaling pathway_Homo sapiens_hsa049221.18704557
27Fatty acid metabolism_Homo sapiens_hsa012121.18438282
28HIF-1 signaling pathway_Homo sapiens_hsa040661.13970800
29Insulin resistance_Homo sapiens_hsa049311.13140132
30Insulin signaling pathway_Homo sapiens_hsa049101.10479047
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.07898758
32Amoebiasis_Homo sapiens_hsa051461.07765989
33Biosynthesis of amino acids_Homo sapiens_hsa012301.06263259
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05758519
35Starch and sucrose metabolism_Homo sapiens_hsa005001.05327125
36Oxytocin signaling pathway_Homo sapiens_hsa049211.04200494
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03142505
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.00483778
39Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97922921
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.96791623
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.91078757
42Axon guidance_Homo sapiens_hsa043600.90981276
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90925652
44Hippo signaling pathway_Homo sapiens_hsa043900.89624792
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86363469
46Galactose metabolism_Homo sapiens_hsa000520.85291042
47Small cell lung cancer_Homo sapiens_hsa052220.84164677
48AMPK signaling pathway_Homo sapiens_hsa041520.83906700
49Bladder cancer_Homo sapiens_hsa052190.74928149
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74856252
51Pentose phosphate pathway_Homo sapiens_hsa000300.68803784
52Calcium signaling pathway_Homo sapiens_hsa040200.67444491
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66717120
54Sulfur relay system_Homo sapiens_hsa041220.65758651
55TGF-beta signaling pathway_Homo sapiens_hsa043500.63681487
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61983451
57Platelet activation_Homo sapiens_hsa046110.61452405
58Arginine biosynthesis_Homo sapiens_hsa002200.60261609
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59739028
60Thyroid hormone synthesis_Homo sapiens_hsa049180.58472105
61Basal cell carcinoma_Homo sapiens_hsa052170.58051252
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56445796
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55963679
64Fructose and mannose metabolism_Homo sapiens_hsa000510.55294410
65Protein digestion and absorption_Homo sapiens_hsa049740.54566412
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53475401
67Pancreatic secretion_Homo sapiens_hsa049720.51521071
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51318689
69PPAR signaling pathway_Homo sapiens_hsa033200.50998898
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49891829
71Notch signaling pathway_Homo sapiens_hsa043300.49767888
72Arginine and proline metabolism_Homo sapiens_hsa003300.49349309
73Insulin secretion_Homo sapiens_hsa049110.48550805
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48538777
75Renal cell carcinoma_Homo sapiens_hsa052110.48253934
76Gastric acid secretion_Homo sapiens_hsa049710.45489318
77Melanoma_Homo sapiens_hsa052180.44965188
78Gap junction_Homo sapiens_hsa045400.43885192
79* MicroRNAs in cancer_Homo sapiens_hsa052060.43693440
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42963412
81VEGF signaling pathway_Homo sapiens_hsa043700.42651350
82Prostate cancer_Homo sapiens_hsa052150.42263179
83GnRH signaling pathway_Homo sapiens_hsa049120.41363372
84mTOR signaling pathway_Homo sapiens_hsa041500.41103036
85Rap1 signaling pathway_Homo sapiens_hsa040150.41027486
86Hedgehog signaling pathway_Homo sapiens_hsa043400.40142406
87Lysine degradation_Homo sapiens_hsa003100.39789867
88Circadian rhythm_Homo sapiens_hsa047100.38419773
89Melanogenesis_Homo sapiens_hsa049160.38258939
90FoxO signaling pathway_Homo sapiens_hsa040680.37883766
91Chronic myeloid leukemia_Homo sapiens_hsa052200.37837465
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37610369
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36983272
94Pathways in cancer_Homo sapiens_hsa052000.36849551
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33850801
96cAMP signaling pathway_Homo sapiens_hsa040240.32003490
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.31501607
98Type II diabetes mellitus_Homo sapiens_hsa049300.31054610
99Salmonella infection_Homo sapiens_hsa051320.30791848
100Toxoplasmosis_Homo sapiens_hsa051450.29683679
101Ribosome_Homo sapiens_hsa030100.29476587
102Bile secretion_Homo sapiens_hsa049760.29190768
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28988062
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28574611
105Renin secretion_Homo sapiens_hsa049240.28071763
106HTLV-I infection_Homo sapiens_hsa051660.27961324
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27740273
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26413979
109Butanoate metabolism_Homo sapiens_hsa006500.24850698
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24352263
111Wnt signaling pathway_Homo sapiens_hsa043100.23576669
112Colorectal cancer_Homo sapiens_hsa052100.23549420
113Glioma_Homo sapiens_hsa052140.22841177
114MAPK signaling pathway_Homo sapiens_hsa040100.22325036
115Endometrial cancer_Homo sapiens_hsa052130.22117059
116Thyroid cancer_Homo sapiens_hsa052160.19929759
117p53 signaling pathway_Homo sapiens_hsa041150.19740426
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17064353
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16737559
120Fatty acid elongation_Homo sapiens_hsa000620.16373376

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