TPM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72869965
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72869965
3ribosomal small subunit assembly (GO:0000028)3.63785877
4positive regulation of gamma-delta T cell activation (GO:0046645)3.50566262
5antigen processing and presentation of endogenous antigen (GO:0019883)3.39565364
6DNA strand elongation involved in DNA replication (GO:0006271)3.39009450
7Arp2/3 complex-mediated actin nucleation (GO:0034314)3.36813362
8telomere maintenance via semi-conservative replication (GO:0032201)3.32726506
9DNA unwinding involved in DNA replication (GO:0006268)3.28804694
10IMP biosynthetic process (GO:0006188)3.27433410
11DNA strand elongation (GO:0022616)3.25085528
12negative regulation of phagocytosis (GO:0050765)3.22335779
13definitive hemopoiesis (GO:0060216)3.19033939
14megakaryocyte development (GO:0035855)3.18696722
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15019541
16response to peptidoglycan (GO:0032494)3.11237890
17IMP metabolic process (GO:0046040)3.08742371
18telomere maintenance via recombination (GO:0000722)3.07316224
19DNA replication initiation (GO:0006270)3.03710240
20* muscle filament sliding (GO:0030049)3.00506426
21* actin-myosin filament sliding (GO:0033275)3.00506426
22establishment of integrated proviral latency (GO:0075713)2.95539428
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93061680
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87883812
25negative regulation of cell killing (GO:0031342)2.87883812
26regulation of B cell receptor signaling pathway (GO:0050855)2.87657926
27ribosome assembly (GO:0042255)2.85041019
28mitotic recombination (GO:0006312)2.84378995
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80219469
30skeletal muscle contraction (GO:0003009)2.78015157
31hepatocyte apoptotic process (GO:0097284)2.76973507
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76045242
33positive regulation of lamellipodium assembly (GO:0010592)2.72817736
34protein localization to kinetochore (GO:0034501)2.71442061
35regulation of gamma-delta T cell differentiation (GO:0045586)2.70442549
36establishment of viral latency (GO:0019043)2.68109452
37negative regulation of necroptotic process (GO:0060546)2.67885317
38maturation of SSU-rRNA (GO:0030490)2.66115893
39mitotic nuclear envelope disassembly (GO:0007077)2.64885303
403-UTR-mediated mRNA stabilization (GO:0070935)2.63892290
41telomere maintenance via telomere lengthening (GO:0010833)2.61454881
42membrane raft organization (GO:0031579)2.61136456
43positive regulation of B cell differentiation (GO:0045579)2.60728242
44immunoglobulin mediated immune response (GO:0016064)2.60534804
45regulation of interleukin-12 biosynthetic process (GO:0045075)2.60333062
46B cell mediated immunity (GO:0019724)2.57840568
47viral transcription (GO:0019083)2.57579574
48formation of translation preinitiation complex (GO:0001731)2.56983300
49nuclear pore organization (GO:0006999)2.55349386
50regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54383127
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54164561
52regulation of gamma-delta T cell activation (GO:0046643)2.53887404
53translational termination (GO:0006415)2.52601070
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52325823
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.52325823
56modulation by symbiont of host immune response (GO:0052553)2.52325823
57positive regulation by symbiont of host defense response (GO:0052509)2.52325823
58modulation by symbiont of host defense response (GO:0052031)2.52325823
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52325823
60NIK/NF-kappaB signaling (GO:0038061)2.51498994
61myeloid dendritic cell activation (GO:0001773)2.51417639
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48103426
63COPI coating of Golgi vesicle (GO:0048205)2.47887205
64Golgi transport vesicle coating (GO:0048200)2.47887205
65DNA replication checkpoint (GO:0000076)2.47652448
66pinocytosis (GO:0006907)2.47559957
67nuclear pore complex assembly (GO:0051292)2.46989736
68positive thymic T cell selection (GO:0045059)2.46023902
69interferon-gamma production (GO:0032609)2.45902429
70pentose-phosphate shunt (GO:0006098)2.45717968
71nucleobase biosynthetic process (GO:0046112)2.45708943
72cellular hyperosmotic response (GO:0071474)2.45295690
73leukocyte aggregation (GO:0070486)2.45084786
74chaperone mediated protein folding requiring cofactor (GO:0051085)2.45070780
75NADH metabolic process (GO:0006734)2.44522089
76mast cell activation (GO:0045576)2.43019913
77nuclear envelope disassembly (GO:0051081)2.42772422
78membrane disassembly (GO:0030397)2.42772422
79antigen processing and presentation via MHC class Ib (GO:0002475)2.36997669
80purine nucleotide salvage (GO:0032261)2.36827094
81* actin-mediated cell contraction (GO:0070252)2.35897612
82sarcoplasmic reticulum calcium ion transport (GO:0070296)2.35552582
83cellular extravasation (GO:0045123)2.35493505
84actin nucleation (GO:0045010)2.35491288
85regulation of B cell differentiation (GO:0045577)2.35342146
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.34991909
87ribosomal large subunit biogenesis (GO:0042273)2.34327699
88negative regulation of ligase activity (GO:0051352)2.33972774
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.33972774
90detection of other organism (GO:0098543)2.33721355
91positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.31203222
92protein maturation by protein folding (GO:0022417)2.30150937
93T cell apoptotic process (GO:0070231)2.29405247
94telomere maintenance (GO:0000723)2.29152041
95DNA duplex unwinding (GO:0032508)2.28947663
96regulation of response to interferon-gamma (GO:0060330)2.28839012
97negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.28659037
98DNA geometric change (GO:0032392)2.28253436
99positive regulation of protein import into nucleus, translocation (GO:0033160)2.27978235
100mitotic chromosome condensation (GO:0007076)2.27919606
101regulation of spindle organization (GO:0090224)2.26878567
102negative regulation of erythrocyte differentiation (GO:0045647)2.26794676
103angiogenesis involved in wound healing (GO:0060055)2.26637858
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.26573735
105response to interferon-beta (GO:0035456)2.26321256
106telomere organization (GO:0032200)2.26303713
107ribosomal small subunit biogenesis (GO:0042274)2.26133466
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.25973704
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.25304828
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.25246692
111translational elongation (GO:0006414)2.25027055
112purine nucleobase metabolic process (GO:0006144)2.24515301
113response to protozoan (GO:0001562)2.24318089
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.24075804
115positive regulation of interferon-alpha production (GO:0032727)2.23672973
116detection of bacterium (GO:0016045)2.23453691
117protein localization to chromosome, centromeric region (GO:0071459)2.23257335
118B cell receptor signaling pathway (GO:0050853)2.23193504
119response to type I interferon (GO:0034340)2.22780065
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.22397463
121NADPH regeneration (GO:0006740)2.21495839
122negative thymic T cell selection (GO:0045060)2.21362657
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.21361427
124AMP metabolic process (GO:0046033)2.21330733
125cellular response to type I interferon (GO:0071357)2.21033494
126type I interferon signaling pathway (GO:0060337)2.21033494
127negative T cell selection (GO:0043383)2.20005342
128respiratory burst (GO:0045730)2.19787762
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.19380889
130T cell homeostasis (GO:0043029)2.18999886
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.18988248
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.18869112
133negative regulation of interleukin-12 production (GO:0032695)2.18208979
134regulation of mast cell degranulation (GO:0043304)2.18073224
135DNA topological change (GO:0006265)2.17650967
136translational initiation (GO:0006413)2.17219511
137purine nucleobase biosynthetic process (GO:0009113)2.16249892
138myeloid cell activation involved in immune response (GO:0002275)2.15709035
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.15392018
140regulation of necroptotic process (GO:0060544)2.15057687
141neutrophil activation (GO:0042119)2.15014062
142morphogenesis of an endothelium (GO:0003159)2.14944045
143endothelial tube morphogenesis (GO:0061154)2.14944045
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.14660402
145regulation of translational termination (GO:0006449)2.14456745
146regulation of cellular amino acid metabolic process (GO:0006521)2.13773836
147neutrophil activation involved in immune response (GO:0002283)2.12822339
148regulation of T cell receptor signaling pathway (GO:0050856)2.12742386
149positive regulation of macrophage differentiation (GO:0045651)2.12461849
150T cell migration (GO:0072678)2.12014625
151defense response to protozoan (GO:0042832)2.11867894
152regulation of interferon-alpha production (GO:0032647)2.11802737
153ribonucleoprotein complex biogenesis (GO:0022613)2.11566365
154G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.11175665
155regulation of superoxide anion generation (GO:0032928)2.10471906
156folic acid-containing compound biosynthetic process (GO:0009396)2.10034545
157intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.09969352
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.09969352
159tricarboxylic acid cycle (GO:0006099)2.09826098
160protein targeting to ER (GO:0045047)2.09606616
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.09359599
162pore complex assembly (GO:0046931)2.09144429
163cotranslational protein targeting to membrane (GO:0006613)2.09014823
164positive regulation of interferon-beta production (GO:0032728)2.08566276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83596859
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.50291797
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.14456468
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.85315163
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78947575
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76660401
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.68653388
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65613651
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50156116
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.41347482
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40437388
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38253752
13MYC_22102868_ChIP-Seq_BL_Human2.36121793
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35255916
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34288608
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.33179819
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30608090
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08128425
19SCL_19346495_ChIP-Seq_HPC-7_Human2.05452983
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04413096
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95513891
22* SPI1_23547873_ChIP-Seq_NB4_Human1.94151658
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92601055
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89812589
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86740027
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85915938
27VDR_21846776_ChIP-Seq_THP-1_Human1.82911853
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78289235
29MYB_26560356_Chip-Seq_TH2_Human1.77589639
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77321296
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72654092
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.72538367
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.70449713
34MAF_26560356_Chip-Seq_TH1_Human1.70280548
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70137887
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66906249
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65668204
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65294519
39* E2F1_21310950_ChIP-Seq_MCF-7_Human1.64317685
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63851396
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63109291
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62800111
43* MYB_26560356_Chip-Seq_TH1_Human1.60799495
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.58067518
45VDR_23849224_ChIP-Seq_CD4+_Human1.57205844
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56304600
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.54491985
48XRN2_22483619_ChIP-Seq_HELA_Human1.53906000
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49889836
50* ELK1_19687146_ChIP-ChIP_HELA_Human1.49524890
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.48759408
52CIITA_25753668_ChIP-Seq_RAJI_Human1.46110398
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45989898
54FOXP3_21729870_ChIP-Seq_TREG_Human1.45795507
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43370451
56UTX_26944678_Chip-Seq_JUKART_Human1.43042204
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40328364
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38847041
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.38095934
60AR_21909140_ChIP-Seq_LNCAP_Human1.38030126
61* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37410877
62VDR_24763502_ChIP-Seq_THP-1_Human1.36715411
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35569057
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33926424
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33200351
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29310911
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29001042
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28746774
69RUNX_20019798_ChIP-Seq_JUKART_Human1.25889201
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.25481129
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24877443
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24486569
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23780365
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21813573
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.21007248
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19377585
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.18565257
78ZNF263_19887448_ChIP-Seq_K562_Human1.18399670
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17197626
80TFEB_21752829_ChIP-Seq_HELA_Human1.16766497
81DCP1A_22483619_ChIP-Seq_HELA_Human1.16626283
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16159308
83TTF2_22483619_ChIP-Seq_HELA_Human1.15553319
84* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14199947
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14118018
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13831925
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12636821
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11688325
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11590336
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11363265
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10396679
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09242980
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08981576
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07817922
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06461710
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06024917
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05402918
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04241988
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.04095109
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03965094
101* MAF_26560356_Chip-Seq_TH2_Human1.03812021
102* GABP_19822575_ChIP-Seq_HepG2_Human1.03624130
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01597728
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00916344
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99822738
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99815973
107* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99615669
108GATA1_22025678_ChIP-Seq_K562_Human0.98900151
109SRF_21415370_ChIP-Seq_HL-1_Mouse0.97937172
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97729182
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97585084
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97547267
113PU_27001747_Chip-Seq_BMDM_Mouse0.97457114
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96914541
115* KDM5A_27292631_Chip-Seq_BREAST_Human0.95179354
116* SPI1_23127762_ChIP-Seq_K562_Human0.94433312
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93182517
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90589768
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89269094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.36725610
2MP0002396_abnormal_hematopoietic_system3.11458216
3MP0001835_abnormal_antigen_presentation2.97806131
4MP0003693_abnormal_embryo_hatching2.48081987
5MP0005671_abnormal_response_to2.47161725
6MP0003763_abnormal_thymus_physiology2.47087082
7MP0010094_abnormal_chromosome_stability2.34164156
8MP0004808_abnormal_hematopoietic_stem2.32683466
9MP0009785_altered_susceptibility_to2.25413133
10MP0003806_abnormal_nucleotide_metabolis2.24147564
11MP0003436_decreased_susceptibility_to2.20725928
12MP0000685_abnormal_immune_system2.12871248
13MP0001800_abnormal_humoral_immune2.11848724
14MP0002452_abnormal_antigen_presenting2.11832564
15MP0003111_abnormal_nucleus_morphology2.10183235
16MP0003077_abnormal_cell_cycle2.08579482
17MP0008007_abnormal_cellular_replicative2.08276846
18MP0002398_abnormal_bone_marrow2.03865869
19MP0009333_abnormal_splenocyte_physiolog2.03672066
20MP0002420_abnormal_adaptive_immunity2.02563765
21MP0001819_abnormal_immune_cell2.01324626
22MP0005000_abnormal_immune_tolerance1.99213195
23MP0005025_abnormal_response_to1.93101197
24MP0003191_abnormal_cellular_cholesterol1.92736374
25MP0008057_abnormal_DNA_replication1.92016251
26MP0002723_abnormal_immune_serum1.90841707
27MP0002148_abnormal_hypersensitivity_rea1.89957568
28MP0010352_gastrointestinal_tract_polyps1.89589672
29MP0006054_spinal_hemorrhage1.89502742
30MP0005397_hematopoietic_system_phenotyp1.88793629
31MP0001545_abnormal_hematopoietic_system1.88793629
32MP0002419_abnormal_innate_immunity1.87422222
33MP0004957_abnormal_blastocyst_morpholog1.86030956
34MP0000749_muscle_degeneration1.85174657
35MP0003646_muscle_fatigue1.84652946
36MP0000490_abnormal_crypts_of1.84564786
37MP0004233_abnormal_muscle_weight1.82726396
38MP0005464_abnormal_platelet_physiology1.80951845
39MP0001790_abnormal_immune_system1.75224124
40MP0005387_immune_system_phenotype1.75224124
41MP0002722_abnormal_immune_system1.73204739
42MP0002405_respiratory_system_inflammati1.73101937
43MP0000689_abnormal_spleen_morphology1.71874215
44MP0000716_abnormal_immune_system1.71792375
45MP0003303_peritoneal_inflammation1.71023297
46MP0002877_abnormal_melanocyte_morpholog1.70833052
47MP0002166_altered_tumor_susceptibility1.69356046
48MP0010155_abnormal_intestine_physiology1.69115318
49MP0003724_increased_susceptibility_to1.66746948
50MP0010307_abnormal_tumor_latency1.64368875
51MP0000751_myopathy1.64301615
52MP0000703_abnormal_thymus_morphology1.59718051
53MP0001853_heart_inflammation1.59443765
54MP0009278_abnormal_bone_marrow1.59197745
55MP0002429_abnormal_blood_cell1.58700978
56MP0008260_abnormal_autophagy1.54516675
57MP0000858_altered_metastatic_potential1.50945269
58MP0005058_abnormal_lysosome_morphology1.49779471
59MP0005174_abnormal_tail_pigmentation1.48539379
60MP0001873_stomach_inflammation1.47141902
61MP0002006_tumorigenesis1.46423958
62MP0004036_abnormal_muscle_relaxation1.46268429
63MP0000465_gastrointestinal_hemorrhage1.46256404
64MP0002332_abnormal_exercise_endurance1.43020641
65MP0008058_abnormal_DNA_repair1.42759835
66MP0000747_muscle_weakness1.38411586
67MP0004185_abnormal_adipocyte_glucose1.35273612
68MP0004145_abnormal_muscle_electrophysio1.32948031
69MP0004087_abnormal_muscle_fiber1.32217200
70MP0002019_abnormal_tumor_incidence1.30982867
71MP0000759_abnormal_skeletal_muscle1.29446873
72MP0006082_CNS_inflammation1.28554649
73MP0006036_abnormal_mitochondrial_physio1.27946266
74MP0003221_abnormal_cardiomyocyte_apopto1.27872503
75MP0003300_gastrointestinal_ulcer1.26825762
76MP0003448_altered_tumor_morphology1.25334730
77MP0003566_abnormal_cell_adhesion1.25140486
78MP0001845_abnormal_inflammatory_respons1.25037479
79MP0005330_cardiomyopathy1.22119627
80MP0004947_skin_inflammation1.21957162
81MP0000350_abnormal_cell_proliferation1.18858354
82MP0003656_abnormal_erythrocyte_physiolo1.18037343
83MP0002132_abnormal_respiratory_system1.17493003
84MP0002269_muscular_atrophy1.13988070
85MP0002106_abnormal_muscle_physiology1.13734498
86MP0002095_abnormal_skin_pigmentation1.12848115
87MP0005023_abnormal_wound_healing1.11569895
88MP0000015_abnormal_ear_pigmentation1.10193641
89MP0001533_abnormal_skeleton_physiology1.07436460
90MP0003950_abnormal_plasma_membrane1.05689763
91MP0002796_impaired_skin_barrier1.04275846
92MP0001915_intracranial_hemorrhage1.04198048
93MP0003866_abnormal_defecation1.02145012
94MP0001730_embryonic_growth_arrest1.00226014
95MP0005165_increased_susceptibility_to0.99936195
96MP0003943_abnormal_hepatobiliary_system0.99840201
97MP0003279_aneurysm0.99495080
98MP0008932_abnormal_embryonic_tissue0.99237049
99MP0000343_altered_response_to0.99127023
100MP0005075_abnormal_melanosome_morpholog0.98705383
101MP0000313_abnormal_cell_death0.98013628
102MP0003828_pulmonary_edema0.96352258
103MP0005076_abnormal_cell_differentiation0.93784456
104MP0003567_abnormal_fetal_cardiomyocyte0.93100595
105MP0003075_altered_response_to0.92248396
106MP0003786_premature_aging0.91182890
107MP0005166_decreased_susceptibility_to0.91120235
108MP0001879_abnormal_lymphatic_vessel0.89955896
109MP0002933_joint_inflammation0.89624509
110MP0002998_abnormal_bone_remodeling0.87267057
111MP0000750_abnormal_muscle_regeneration0.87198597
112MP0004084_abnormal_cardiac_muscle0.86683560
113MP0001727_abnormal_embryo_implantation0.86085019
114MP0002086_abnormal_extraembryonic_tissu0.85057828
115MP0001851_eye_inflammation0.84976352
116MP0010630_abnormal_cardiac_muscle0.84676516
117MP0009697_abnormal_copulation0.82418138
118MP0003984_embryonic_growth_retardation0.82187212
119MP0002088_abnormal_embryonic_growth/wei0.79383888
120MP0001672_abnormal_embryogenesis/_devel0.79151042
121MP0005380_embryogenesis_phenotype0.79151042
122MP0008469_abnormal_protein_level0.77969628
123MP0000767_abnormal_smooth_muscle0.75632948
124MP0001697_abnormal_embryo_size0.74153982
125* MP0002080_prenatal_lethality0.72750213
126MP0000477_abnormal_intestine_morphology0.70274104
127MP0004782_abnormal_surfactant_physiolog0.68686617
128MP0005390_skeleton_phenotype0.67760852
129MP0000249_abnormal_blood_vessel0.65290445
130MP0001191_abnormal_skin_condition0.63941685
131MP0003091_abnormal_cell_migration0.63580213
132MP0004197_abnormal_fetal_growth/weight/0.61824337
133MP0000733_abnormal_muscle_development0.61543678

Predicted human phenotypes

RankGene SetZ-score
1* Muscle fiber inclusion bodies (HP:0100299)6.23398723
2* Nemaline bodies (HP:0003798)6.13150583
3* Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.08786060
4Exercise-induced myalgia (HP:0003738)4.58654958
5Type 1 muscle fiber predominance (HP:0003803)4.25779888
6Exercise-induced muscle cramps (HP:0003710)4.12797739
7Rhabdomyolysis (HP:0003201)3.82765920
8Recurrent abscess formation (HP:0002722)3.67583193
9Increased connective tissue (HP:0009025)3.66451118
10Elevated erythrocyte sedimentation rate (HP:0003565)3.64977320
11Thrombocytosis (HP:0001894)3.53789207
12Eczematoid dermatitis (HP:0000976)3.50954472
13Myositis (HP:0100614)3.39505787
14Myopathic facies (HP:0002058)3.37581346
15IgM deficiency (HP:0002850)3.31432833
16* Centrally nucleated skeletal muscle fibers (HP:0003687)3.31258530
17Recurrent viral infections (HP:0004429)3.17414880
18Recurrent fungal infections (HP:0002841)3.11713058
19Recurrent bacterial skin infections (HP:0005406)3.05607911
20Chronic otitis media (HP:0000389)3.03862113
21Myoglobinuria (HP:0002913)2.97314612
22Progressive muscle weakness (HP:0003323)2.96145810
23* EMG: myopathic abnormalities (HP:0003458)2.94040601
24Distal arthrogryposis (HP:0005684)2.90144369
25Aplastic anemia (HP:0001915)2.89163283
26Muscle stiffness (HP:0003552)2.84790067
27Fatigue (HP:0012378)2.79545355
28* Neck muscle weakness (HP:0000467)2.79231906
29Cellulitis (HP:0100658)2.72759026
30Reticulocytopenia (HP:0001896)2.70107173
31* Abnormality of skeletal muscle fiber size (HP:0012084)2.69375178
32Recurrent bronchitis (HP:0002837)2.68954125
33Abnormality of T cells (HP:0002843)2.66824703
34Cutaneous melanoma (HP:0012056)2.66764229
35Petechiae (HP:0000967)2.62867349
36Mediastinal lymphadenopathy (HP:0100721)2.60979706
37Muscle fiber splitting (HP:0003555)2.60410509
38Abnormality of T cell physiology (HP:0011840)2.55128657
39Orchitis (HP:0100796)2.54284999
40Agnosia (HP:0010524)2.53230001
41T lymphocytopenia (HP:0005403)2.51160968
42Chromsome breakage (HP:0040012)2.50293816
43Abnormality of T cell number (HP:0011839)2.48228859
44Abnormality of the fingertips (HP:0001211)2.42614687
45Ulnar deviation of the wrist (HP:0003049)2.41326016
46Amaurosis fugax (HP:0100576)2.40532110
47Ragged-red muscle fibers (HP:0003200)2.37821129
48Increased variability in muscle fiber diameter (HP:0003557)2.36607221
49Acute myeloid leukemia (HP:0004808)2.35533817
50Areflexia of lower limbs (HP:0002522)2.35533420
51Abnormality of the left ventricular outflow tract (HP:0011103)2.33697519
52Subaortic stenosis (HP:0001682)2.33697519
53Myelodysplasia (HP:0002863)2.33424180
54Abnormality of the prostate (HP:0008775)2.32483643
55Spontaneous hematomas (HP:0007420)2.31569810
56Pelvic girdle muscle weakness (HP:0003749)2.31568644
57Pustule (HP:0200039)2.31183637
58Lymphoma (HP:0002665)2.29568016
59Prolonged bleeding time (HP:0003010)2.28471451
60Entropion (HP:0000621)2.28302706
61Leukocytosis (HP:0001974)2.27204781
62Autoimmune thrombocytopenia (HP:0001973)2.27134885
63Meningitis (HP:0001287)2.26988735
64Hyporeflexia of lower limbs (HP:0002600)2.26579874
65Rimmed vacuoles (HP:0003805)2.25774850
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.24827383
67Difficulty climbing stairs (HP:0003551)2.24359589
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.23897550
69Abnormality of macrophages (HP:0004311)2.22434248
70Lymphopenia (HP:0001888)2.22107341
71Retrobulbar optic neuritis (HP:0100654)2.21883908
72Optic neuritis (HP:0100653)2.21883908
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21817781
74* Distal lower limb muscle weakness (HP:0009053)2.21518835
75Chronic obstructive pulmonary disease (HP:0006510)2.21497544
76Obstructive lung disease (HP:0006536)2.21497544
77Prostate neoplasm (HP:0100787)2.21109695
78Eosinophilia (HP:0001880)2.20486121
79Granulocytopenia (HP:0001913)2.20315961
80Round ear (HP:0100830)2.20214004
81Muscle hypertrophy of the lower extremities (HP:0008968)2.19109651
82Autoimmune hemolytic anemia (HP:0001890)2.18289934
8311 pairs of ribs (HP:0000878)2.18092840
84Interstitial pulmonary disease (HP:0006530)2.16603424
85Multiple enchondromatosis (HP:0005701)2.16379963
86Abnormality of eosinophils (HP:0001879)2.15786350
87Basal cell carcinoma (HP:0002671)2.15620832
88Birth length less than 3rd percentile (HP:0003561)2.13256883
89IgA deficiency (HP:0002720)2.13031842
90Panhypogammaglobulinemia (HP:0003139)2.11418565
91Increased IgM level (HP:0003496)2.11284280
92Abnormality of the anterior horn cell (HP:0006802)2.10411441
93Degeneration of anterior horn cells (HP:0002398)2.10411441
94Poikiloderma (HP:0001029)2.10167642
95IgG deficiency (HP:0004315)2.06738971
96B lymphocytopenia (HP:0010976)2.06316422
97Abnormality of B cell number (HP:0010975)2.06316422
98Asymmetric septal hypertrophy (HP:0001670)2.06073959
99Progressive external ophthalmoplegia (HP:0000590)2.04992016
100Spinal cord lesions (HP:0100561)2.04923754
101Syringomyelia (HP:0003396)2.04923754
102Osteolytic defects of the hand bones (HP:0009699)2.04609543
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.04609543
104Recurrent skin infections (HP:0001581)2.02952906
105Trismus (HP:0000211)2.02792130
106Recurrent cutaneous fungal infections (HP:0011370)2.01944121
107Chronic mucocutaneous candidiasis (HP:0002728)2.01944121
108Difficulty running (HP:0009046)2.01636238
109Abnormality of the calcaneus (HP:0008364)1.98292519
110Vasculitis (HP:0002633)1.97647859
111Gastrointestinal inflammation (HP:0004386)1.96236344
112Periodontitis (HP:0000704)1.95807157
113Increased mean platelet volume (HP:0011877)1.94611089
114Inflammation of the large intestine (HP:0002037)1.94456117
115Vacuolated lymphocytes (HP:0001922)1.93997669
116Arterial thrombosis (HP:0004420)1.92945649
117Paralysis (HP:0003470)1.92330388
118Reduced subcutaneous adipose tissue (HP:0003758)1.91884686
119Hepatosplenomegaly (HP:0001433)1.91616022
120Stomatitis (HP:0010280)1.91268408
121Calcaneovalgus deformity (HP:0001848)1.90670147
122Shoulder girdle muscle weakness (HP:0003547)1.90650558
123Abnormality of cells of the erythroid lineage (HP:0012130)1.89933990
124Epistaxis (HP:0000421)1.88623378
125Osteomyelitis (HP:0002754)1.88398305
126Abnormal platelet volume (HP:0011876)1.88248984
127Selective tooth agenesis (HP:0001592)1.88182060
128* Distal lower limb amyotrophy (HP:0008944)1.87884129
129Abnormal number of erythroid precursors (HP:0012131)1.86027175
130Urticaria (HP:0001025)1.85525338
131Abnormality of the nasal mucosa (HP:0000433)1.84952139
132Abnormality of chromosome stability (HP:0003220)1.84515250
133Gingival bleeding (HP:0000225)1.84065057
134Abnormal platelet function (HP:0011869)1.84039343
135Impaired platelet aggregation (HP:0003540)1.84039343
136Agammaglobulinemia (HP:0004432)1.82019619
137Keratoconjunctivitis sicca (HP:0001097)1.79977308
138Abnormality of the hip-girdle musculature (HP:0001445)1.79932976
139Abnormality of the musculature of the pelvis (HP:0001469)1.79932976
140Nasal polyposis (HP:0100582)1.79272329
141Thyroiditis (HP:0100646)1.78768284
142Chest pain (HP:0100749)1.78494718
143Basal ganglia calcification (HP:0002135)1.77839549
144Increased density of long bones (HP:0006392)1.77674972
145Severe combined immunodeficiency (HP:0004430)1.76527423
146Encephalitis (HP:0002383)1.76168709
147Achilles tendon contracture (HP:0001771)1.76105723
148Hematochezia (HP:0002573)1.75792421
149Pulmonary infiltrates (HP:0002113)1.75528713
150Reduced antithrombin III activity (HP:0001976)1.74995171
151Skin ulcer (HP:0200042)1.74600144
152Clubbing of toes (HP:0100760)1.72973869
153Spinal rigidity (HP:0003306)1.72743321
154Menorrhagia (HP:0000132)1.72589710
155Bone marrow hypocellularity (HP:0005528)1.72269873
156Increased IgE level (HP:0003212)1.72015687
157Chronic diarrhea (HP:0002028)1.71602514
158Increased intramyocellular lipid droplets (HP:0012240)1.71422559
159Myocardial infarction (HP:0001658)1.71383751
160Rough bone trabeculation (HP:0100670)1.71331310
161Vertebral compression fractures (HP:0002953)1.70439292
162Calf muscle hypertrophy (HP:0008981)1.70276088
163Colitis (HP:0002583)1.68256490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.32227347
2OBSCN3.28601097
3KIT2.37956696
4TXK2.29147450
5STK102.24087155
6MAP3K142.13945108
7JAK32.09439176
8IRAK42.04168148
9CDC72.03615573
10RIPK41.99355228
11WEE11.97162005
12PRPF4B1.96703287
13NME21.90380863
14VRK21.86137922
15ZAP701.84353999
16TSSK61.79464800
17BTK1.79043115
18RPS6KA41.78575548
19PIM21.78172625
20EEF2K1.72847931
21TGFBR11.71183843
22TEC1.70184798
23MAP2K31.65659464
24TYK21.64831222
25BUB11.61467140
26NEK91.60809003
27CLK11.49854080
28PBK1.47050318
29BLK1.45278506
30TBK11.44671422
31ACVR1B1.41272453
32RPS6KB21.41129136
33MAP3K131.40884217
34TESK21.35785696
35FLT31.35778467
36NEK11.33341439
37KDR1.32942308
38PIM11.29185283
39LRRK21.27296707
40BRSK21.26753284
41NEK21.26576385
42FES1.26026130
43IKBKE1.25976417
44MKNK11.25366366
45BMPR21.24011359
46PKN21.22622069
47PAK41.21847714
48IKBKB1.20956851
49ITK1.20355783
50IRAK31.19703536
51MATK1.16527454
52TGFBR21.16013671
53PASK1.15414407
54SRPK11.11108643
55ATR1.09745335
56CSF1R1.08856162
57EIF2AK11.07549293
58MAP3K81.04628377
59SMG11.04338922
60CDK41.04017629
61STK41.01000441
62MOS1.00150978
63MAP3K100.99427118
64CDK70.98720706
65ARAF0.98360059
66CHUK0.98060687
67LCK0.97066130
68SYK0.96201488
69MST1R0.95166653
70PHKG20.94639438
71PHKG10.94639438
72EPHA20.92801467
73EIF2AK30.91913361
74MST40.90181338
75CDK120.89922081
76VRK10.89169202
77CDK60.87523801
78HCK0.86814532
79TTN0.86283730
80TRPM70.86055521
81AURKB0.83492324
82GRK60.82531313
83LYN0.80486892
84CSK0.79914157
85MAP3K30.79173592
86MKNK20.78313109
87TIE10.77565700
88NLK0.77285184
89FGFR30.76031721
90TESK10.75860828
91ERN10.75688731
92MAP3K10.75429688
93PLK40.73668714
94EPHB10.73192498
95CDK80.72143933
96DYRK30.69689124
97LIMK10.68891344
98PIK3CG0.68008069
99MAP3K110.67198778
100PLK10.67127493
101JAK10.66051846
102TAOK20.64820007
103ALK0.63562817
104FGR0.62502850
105STK240.62464463
106TRIB30.60214915
107TAOK30.59720409
108SCYL20.56710714
109PTK60.56564664
110MAPK120.55294817
111MAPKAPK20.54793958
112NME10.54163213
113MARK30.52440417
114FGFR40.51992207
115EIF2AK20.51653609
116CDK90.51597088
117PAK10.50914647
118KSR20.50588109
119PLK30.50188596
120SIK30.49542654
121BMX0.48851387
122BCKDK0.48760094
123MAPK110.48217687
124DAPK10.47228173
125RPS6KA60.47145516
126TTK0.46114539
127MAP3K120.45989208
128MAPKAPK30.45963340
129ZAK0.45625160
130STK160.42517280
131RAF10.40575446
132ILK0.40004558

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.43506970
2Mismatch repair_Homo sapiens_hsa034302.65396258
3Base excision repair_Homo sapiens_hsa034102.25198794
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13300888
5Primary immunodeficiency_Homo sapiens_hsa053402.03021653
6Antigen processing and presentation_Homo sapiens_hsa046121.97566771
7Spliceosome_Homo sapiens_hsa030401.96749949
8Ribosome_Homo sapiens_hsa030101.90913084
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87908988
10Leishmaniasis_Homo sapiens_hsa051401.86601390
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86263470
12Homologous recombination_Homo sapiens_hsa034401.81780019
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.81076940
14Measles_Homo sapiens_hsa051621.78356706
15Cell cycle_Homo sapiens_hsa041101.73220994
16Nucleotide excision repair_Homo sapiens_hsa034201.63033854
17Herpes simplex infection_Homo sapiens_hsa051681.62612888
18RNA polymerase_Homo sapiens_hsa030201.58590703
19Legionellosis_Homo sapiens_hsa051341.57894205
20RNA transport_Homo sapiens_hsa030131.57351624
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51965416
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48857565
23Proteasome_Homo sapiens_hsa030501.47822164
24One carbon pool by folate_Homo sapiens_hsa006701.44485266
25B cell receptor signaling pathway_Homo sapiens_hsa046621.44004639
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42312200
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.41372862
28Hematopoietic cell lineage_Homo sapiens_hsa046401.41371064
29p53 signaling pathway_Homo sapiens_hsa041151.40267031
30Shigellosis_Homo sapiens_hsa051311.36414789
31Fanconi anemia pathway_Homo sapiens_hsa034601.34637236
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34396746
33Pyrimidine metabolism_Homo sapiens_hsa002401.34295967
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33807282
35Non-homologous end-joining_Homo sapiens_hsa034501.32684906
36Osteoclast differentiation_Homo sapiens_hsa043801.31938005
37Allograft rejection_Homo sapiens_hsa053301.28741766
38Graft-versus-host disease_Homo sapiens_hsa053321.27147810
39Apoptosis_Homo sapiens_hsa042101.26701950
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24957119
41Epstein-Barr virus infection_Homo sapiens_hsa051691.24879530
42Influenza A_Homo sapiens_hsa051641.21969378
43Viral myocarditis_Homo sapiens_hsa054161.21260705
44Carbon metabolism_Homo sapiens_hsa012001.18896336
45Hepatitis B_Homo sapiens_hsa051611.17612919
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.17543468
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.17298780
48Toxoplasmosis_Homo sapiens_hsa051451.15758917
49Acute myeloid leukemia_Homo sapiens_hsa052211.15242148
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14559750
51RNA degradation_Homo sapiens_hsa030181.12493214
52Viral carcinogenesis_Homo sapiens_hsa052031.11373467
53Galactose metabolism_Homo sapiens_hsa000521.09347791
54T cell receptor signaling pathway_Homo sapiens_hsa046601.09296112
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08294190
56Pertussis_Homo sapiens_hsa051331.07827568
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06989203
58HTLV-I infection_Homo sapiens_hsa051661.06842145
59Chronic myeloid leukemia_Homo sapiens_hsa052201.06351818
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05884374
61Small cell lung cancer_Homo sapiens_hsa052221.03167956
62Malaria_Homo sapiens_hsa051440.99816961
63TNF signaling pathway_Homo sapiens_hsa046680.97881365
64Other glycan degradation_Homo sapiens_hsa005110.94742391
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94344567
66Basal transcription factors_Homo sapiens_hsa030220.92481198
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89742549
68Biosynthesis of amino acids_Homo sapiens_hsa012300.89439778
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88486467
70Salmonella infection_Homo sapiens_hsa051320.88118857
71Rheumatoid arthritis_Homo sapiens_hsa053230.86353761
72Platelet activation_Homo sapiens_hsa046110.84019827
73Phagosome_Homo sapiens_hsa041450.83837547
74Tuberculosis_Homo sapiens_hsa051520.83566465
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83440659
76Fructose and mannose metabolism_Homo sapiens_hsa000510.82976284
77Bladder cancer_Homo sapiens_hsa052190.81242156
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80233334
79mRNA surveillance pathway_Homo sapiens_hsa030150.77331841
80Pancreatic cancer_Homo sapiens_hsa052120.76377791
81MicroRNAs in cancer_Homo sapiens_hsa052060.75950989
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75896769
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75430321
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.70405869
85Hepatitis C_Homo sapiens_hsa051600.68794492
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68401851
87Asthma_Homo sapiens_hsa053100.68327769
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65481039
89Chemokine signaling pathway_Homo sapiens_hsa040620.64403773
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63501091
91Colorectal cancer_Homo sapiens_hsa052100.62314749
92Non-small cell lung cancer_Homo sapiens_hsa052230.61732225
93Autoimmune thyroid disease_Homo sapiens_hsa053200.61337443
94Purine metabolism_Homo sapiens_hsa002300.60077089
95Renal cell carcinoma_Homo sapiens_hsa052110.58979061
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56505272
97Lysosome_Homo sapiens_hsa041420.55534468
98Notch signaling pathway_Homo sapiens_hsa043300.55139963
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.54730522
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54630667
101HIF-1 signaling pathway_Homo sapiens_hsa040660.54340829
102Insulin signaling pathway_Homo sapiens_hsa049100.53929822
103Systemic lupus erythematosus_Homo sapiens_hsa053220.53290981
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.53112212
105* Thyroid cancer_Homo sapiens_hsa052160.52117891
106Adherens junction_Homo sapiens_hsa045200.52112349
107Fatty acid elongation_Homo sapiens_hsa000620.52016117
108N-Glycan biosynthesis_Homo sapiens_hsa005100.50757953
109Endocytosis_Homo sapiens_hsa041440.49287512
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49249393
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47803436
112Staphylococcus aureus infection_Homo sapiens_hsa051500.47293220
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47249486
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43370622
115Prostate cancer_Homo sapiens_hsa052150.43335101
116* Pathways in cancer_Homo sapiens_hsa052000.43283558
117Type I diabetes mellitus_Homo sapiens_hsa049400.42708944
118Proteoglycans in cancer_Homo sapiens_hsa052050.42604572
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42228003
120VEGF signaling pathway_Homo sapiens_hsa043700.42211337
121Prolactin signaling pathway_Homo sapiens_hsa049170.41573265
122Pentose phosphate pathway_Homo sapiens_hsa000300.39725556
123Focal adhesion_Homo sapiens_hsa045100.38472703

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