TPM3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.60026600
2Arp2/3 complex-mediated actin nucleation (GO:0034314)6.38860020
3actin nucleation (GO:0045010)6.08922555
4DNA deamination (GO:0045006)5.93497649
5cytidine metabolic process (GO:0046087)5.91419306
6cytidine catabolic process (GO:0006216)5.91419306
7cytidine deamination (GO:0009972)5.91419306
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.05708742
9cytolysis (GO:0019835)4.79077172
10kynurenine metabolic process (GO:0070189)4.54922521
11protein deneddylation (GO:0000338)4.41967447
12tryptophan catabolic process (GO:0006569)4.20786871
13indole-containing compound catabolic process (GO:0042436)4.20786871
14indolalkylamine catabolic process (GO:0046218)4.20786871
15metallo-sulfur cluster assembly (GO:0031163)3.97918286
16iron-sulfur cluster assembly (GO:0016226)3.97918286
17chaperone mediated protein folding requiring cofactor (GO:0051085)3.81238783
18positive regulation of defense response to virus by host (GO:0002230)3.78168822
19tryptophan metabolic process (GO:0006568)3.63665680
20negative regulation by host of viral transcription (GO:0043922)3.62380169
21DNA dealkylation (GO:0035510)3.56037291
22DNA demethylation (GO:0080111)3.50943326
23negative regulation of stress fiber assembly (GO:0051497)3.47782558
24regulation of activation of Janus kinase activity (GO:0010533)3.45960135
25indolalkylamine metabolic process (GO:0006586)3.40667376
26phosphorylated carbohydrate dephosphorylation (GO:0046838)3.40087837
27inositol phosphate dephosphorylation (GO:0046855)3.40087837
28regulation of B cell receptor signaling pathway (GO:0050855)3.34206829
29positive regulation of uterine smooth muscle contraction (GO:0070474)3.34064393
30mannosylation (GO:0097502)3.33481248
31ubiquinone biosynthetic process (GO:0006744)3.27537878
32regulation of ruffle assembly (GO:1900027)3.27131217
33inositol phosphate catabolic process (GO:0071545)3.25099733
34platelet dense granule organization (GO:0060155)3.23205989
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22310901
36negative T cell selection (GO:0043383)3.21279878
37cytochrome complex assembly (GO:0017004)3.20203022
38proteasome assembly (GO:0043248)3.19642623
39intestinal cholesterol absorption (GO:0030299)3.17816317
40regulation of defense response to virus by host (GO:0050691)3.14488279
41positive regulation of tolerance induction (GO:0002645)3.13349091
42negative regulation of viral genome replication (GO:0045071)3.11220468
43multicellular organism reproduction (GO:0032504)3.10127316
44gonadal mesoderm development (GO:0007506)3.04148803
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03227533
46cellular response to interleukin-15 (GO:0071350)3.03218641
47regulation of cellular amino acid metabolic process (GO:0006521)3.02486958
48positive regulation of prostaglandin secretion (GO:0032308)3.01826626
49ubiquinone metabolic process (GO:0006743)2.97624716
50positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93267638
51protein complex biogenesis (GO:0070271)2.91589868
52protein K63-linked deubiquitination (GO:0070536)2.88379307
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88370901
54negative regulation of actin filament bundle assembly (GO:0032232)2.85897701
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84179675
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84179675
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84179675
58fucose catabolic process (GO:0019317)2.83802845
59L-fucose metabolic process (GO:0042354)2.83802845
60L-fucose catabolic process (GO:0042355)2.83802845
61adaptation of signaling pathway (GO:0023058)2.83383996
62positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80656258
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79386836
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79386836
65base-excision repair, AP site formation (GO:0006285)2.79147692
66preassembly of GPI anchor in ER membrane (GO:0016254)2.78518685
67quinone biosynthetic process (GO:1901663)2.78016661
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77291121
69negative thymic T cell selection (GO:0045060)2.76208566
70positive thymic T cell selection (GO:0045059)2.75954560
71S-adenosylmethionine metabolic process (GO:0046500)2.75931670
72mitochondrial respiratory chain complex assembly (GO:0033108)2.74045510
73respiratory chain complex IV assembly (GO:0008535)2.73212190
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72465761
75pyrimidine nucleoside catabolic process (GO:0046135)2.71686458
76cullin deneddylation (GO:0010388)2.71406614
77regulation of T cell mediated cytotoxicity (GO:0001914)2.68364942
78signal transduction involved in DNA damage checkpoint (GO:0072422)2.67866211
79signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67866211
80positive regulation of cell killing (GO:0031343)2.67651201
81positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.67467186
82positive regulation of natural killer cell mediated immunity (GO:0002717)2.66664658
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.65864108
84protein heterotetramerization (GO:0051290)2.65582223
85regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64716840
86GPI anchor biosynthetic process (GO:0006506)2.64329653
87positive regulation of calcium-mediated signaling (GO:0050850)2.64059364
88T cell migration (GO:0072678)2.64053509
89negative regulation of mast cell activation (GO:0033004)2.63709761
90negative regulation of T cell apoptotic process (GO:0070233)2.63117743
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58844904
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58641283
93piRNA metabolic process (GO:0034587)2.58561064
94GPI anchor metabolic process (GO:0006505)2.57945555
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57438431
96deoxyribonucleotide catabolic process (GO:0009264)2.57206162
97male meiosis (GO:0007140)2.56814784
98deoxyribose phosphate catabolic process (GO:0046386)2.54636948
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54152752
100positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.53198980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57450886
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.54458632
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42490632
4VDR_22108803_ChIP-Seq_LS180_Human3.34856229
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.17840448
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87229932
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.75983301
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58017075
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.52540734
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48937992
11IGF1R_20145208_ChIP-Seq_DFB_Human2.40254154
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39019196
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09912851
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07662274
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.04653383
16MYB_26560356_Chip-Seq_TH2_Human1.99948325
17GATA3_26560356_Chip-Seq_TH2_Human1.99665502
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.98863459
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97088926
20ZNF274_21170338_ChIP-Seq_K562_Hela1.90450235
21VDR_23849224_ChIP-Seq_CD4+_Human1.83042775
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80796596
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78594323
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71220364
25HTT_18923047_ChIP-ChIP_STHdh_Human1.70234221
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69105589
27IRF1_19129219_ChIP-ChIP_H3396_Human1.68365259
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.68055331
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.67549830
30EZH2_22144423_ChIP-Seq_EOC_Human1.66079873
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.64617540
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64201486
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.58269565
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58150969
35AR_20517297_ChIP-Seq_VCAP_Human1.57623213
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56546948
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55856573
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55307372
39GBX2_23144817_ChIP-Seq_PC3_Human1.55213709
40GATA3_27048872_Chip-Seq_THYMUS_Human1.53885246
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53153343
42P300_19829295_ChIP-Seq_ESCs_Human1.50308302
43ER_23166858_ChIP-Seq_MCF-7_Human1.50232122
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47423009
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47144909
46EWS_26573619_Chip-Seq_HEK293_Human1.45784883
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44376670
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44143206
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.43927531
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43484928
51TP53_22573176_ChIP-Seq_HFKS_Human1.41770894
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41498315
53CBP_20019798_ChIP-Seq_JUKART_Human1.38877468
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38877468
55TAF15_26573619_Chip-Seq_HEK293_Human1.38416473
56BCAT_22108803_ChIP-Seq_LS180_Human1.36387166
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.34774646
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33956989
59NANOG_19829295_ChIP-Seq_ESCs_Human1.28413931
60SOX2_19829295_ChIP-Seq_ESCs_Human1.28413931
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28302052
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27146699
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.27146699
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.26633328
65GATA3_26560356_Chip-Seq_TH1_Human1.26428668
66NCOR_22424771_ChIP-Seq_293T_Human1.26165058
67HOXB7_26014856_ChIP-Seq_BT474_Human1.25739990
68ERG_20517297_ChIP-Seq_VCAP_Human1.25543060
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21048374
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.18224866
71TCF4_22108803_ChIP-Seq_LS180_Human1.17335551
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17100840
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16868390
74ELK1_19687146_ChIP-ChIP_HELA_Human1.15477320
75AR_25329375_ChIP-Seq_VCAP_Human1.14222242
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13608971
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13327035
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11277627
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.10932756
80CDX2_22108803_ChIP-Seq_LS180_Human1.10105551
81RXR_22108803_ChIP-Seq_LS180_Human1.09891802
82MYB_26560356_Chip-Seq_TH1_Human1.09284904
83MYC_18940864_ChIP-ChIP_HL60_Human1.07949749
84TCF4_23295773_ChIP-Seq_U87_Human1.07802248
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.06516531
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05189832
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04877219
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03978685
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03656202
90FUS_26573619_Chip-Seq_HEK293_Human1.03175485
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03117836
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03033266
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02872587
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00730554
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.00532380
96AR_21572438_ChIP-Seq_LNCaP_Human1.00510295
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99355806
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98404064
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98308745
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97941953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.23766129
2MP0006072_abnormal_retinal_apoptosis3.63312420
3MP0002102_abnormal_ear_morphology3.37958921
4MP0008875_abnormal_xenobiotic_pharmacok2.79096326
5MP0002166_altered_tumor_susceptibility2.79088625
6MP0004147_increased_porphyrin_level2.73377322
7MP0009785_altered_susceptibility_to2.60629030
8MP0000569_abnormal_digit_pigmentation2.59356203
9MP0002138_abnormal_hepatobiliary_system2.44981770
10MP0003763_abnormal_thymus_physiology2.41344720
11MP0001666_abnormal_nutrient_absorption2.39694894
12MP0003866_abnormal_defecation2.34853386
13MP0002006_tumorigenesis2.22339686
14MP0003950_abnormal_plasma_membrane2.22105524
15MP0001835_abnormal_antigen_presentation2.16345793
16MP0003045_fibrosis2.15465526
17MP0003878_abnormal_ear_physiology2.00915192
18MP0005377_hearing/vestibular/ear_phenot2.00915192
19MP0005387_immune_system_phenotype1.98870143
20MP0001790_abnormal_immune_system1.98870143
21MP0003646_muscle_fatigue1.95628328
22MP0002876_abnormal_thyroid_physiology1.87592817
23MP0005253_abnormal_eye_physiology1.76942094
24MP0001800_abnormal_humoral_immune1.71079044
25MP0005551_abnormal_eye_electrophysiolog1.68685817
26MP0003806_abnormal_nucleotide_metabolis1.65108873
27MP0006292_abnormal_olfactory_placode1.59481688
28MP0000685_abnormal_immune_system1.55160271
29MP0008877_abnormal_DNA_methylation1.54141997
30MP0004145_abnormal_muscle_electrophysio1.50901259
31MP0005025_abnormal_response_to1.48071578
32MP0005645_abnormal_hypothalamus_physiol1.47491832
33MP0002420_abnormal_adaptive_immunity1.46324136
34MP0002723_abnormal_immune_serum1.45262057
35MP0001819_abnormal_immune_cell1.42850068
36MP0005000_abnormal_immune_tolerance1.36161473
37MP0002095_abnormal_skin_pigmentation1.28967270
38MP0002452_abnormal_antigen_presenting1.28413886
39MP0005365_abnormal_bile_salt1.26206567
40MP0003252_abnormal_bile_duct1.26020310
41MP0001905_abnormal_dopamine_level1.25609817
42MP0005410_abnormal_fertilization1.25211088
43MP0005360_urolithiasis1.24169502
44MP0008058_abnormal_DNA_repair1.23790155
45MP0008057_abnormal_DNA_replication1.23687220
46MP0002148_abnormal_hypersensitivity_rea1.20398965
47MP0005075_abnormal_melanosome_morpholog1.20108087
48MP0000372_irregular_coat_pigmentation1.19626213
49MP0003868_abnormal_feces_composition1.18197300
50MP0003195_calcinosis1.16290368
51MP0004134_abnormal_chest_morphology1.15937962
52MP0000427_abnormal_hair_cycle1.13408637
53MP0001501_abnormal_sleep_pattern1.12796482
54MP0005083_abnormal_biliary_tract1.08823178
55MP0003283_abnormal_digestive_organ1.07162722
56MP0001529_abnormal_vocalization1.04791881
57MP0005389_reproductive_system_phenotype1.04060641
58MP0000716_abnormal_immune_system1.01037978
59MP0008872_abnormal_physiological_respon0.99234201
60MP0003786_premature_aging0.97514951
61MP0002653_abnormal_ependyma_morphology0.96648089
62MP0003724_increased_susceptibility_to0.96504111
63MP0005220_abnormal_exocrine_pancreas0.96176762
64MP0002837_dystrophic_cardiac_calcinosis0.94886072
65MP0003448_altered_tumor_morphology0.94314066
66MP0002160_abnormal_reproductive_system0.94196052
67MP0002234_abnormal_pharynx_morphology0.93197599
68MP0010329_abnormal_lipoprotein_level0.93160318
69MP0005085_abnormal_gallbladder_physiolo0.92331183
70MP0005266_abnormal_metabolism0.90924151
71MP0000689_abnormal_spleen_morphology0.90460087
72MP0002736_abnormal_nociception_after0.89534220
73MP0001119_abnormal_female_reproductive0.86917629
74MP0004885_abnormal_endolymph0.86556408
75MP0001485_abnormal_pinna_reflex0.85798573
76MP0002398_abnormal_bone_marrow0.82823750
77MP0001919_abnormal_reproductive_system0.82236945
78MP0002722_abnormal_immune_system0.80908061
79MP0001845_abnormal_inflammatory_respons0.80010613
80MP0009697_abnormal_copulation0.79185555
81MP0005636_abnormal_mineral_homeostasis0.78374561
82MP0006276_abnormal_autonomic_nervous0.77681900
83MP0002419_abnormal_innate_immunity0.77075244
84MP0002009_preneoplasia0.75777453
85MP0001968_abnormal_touch/_nociception0.74772777
86MP0002693_abnormal_pancreas_physiology0.74527105
87MP0002405_respiratory_system_inflammati0.73259027
88MP0010386_abnormal_urinary_bladder0.73220648
89MP0010368_abnormal_lymphatic_system0.72609048
90MP0006054_spinal_hemorrhage0.71350065
91MP0009333_abnormal_splenocyte_physiolog0.71168870
92MP0009763_increased_sensitivity_to0.70771745
93MP0000749_muscle_degeneration0.70121769
94MP0003638_abnormal_response/metabolism_0.69682836
95MP0000703_abnormal_thymus_morphology0.68796870
96MP0002429_abnormal_blood_cell0.68446780
97MP0001502_abnormal_circadian_rhythm0.67362694
98MP0006082_CNS_inflammation0.66634385
99MP0001986_abnormal_taste_sensitivity0.66589645
100MP0001765_abnormal_ion_homeostasis0.66332299

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.93163729
2Aplastic anemia (HP:0001915)3.99626495
3T lymphocytopenia (HP:0005403)3.88068991
4Abnormality of the prostate (HP:0008775)3.73953723
5Abnormality of T cell number (HP:0011839)3.65458915
6IgG deficiency (HP:0004315)3.65297045
7Hepatocellular necrosis (HP:0001404)3.56479116
8Congenital stationary night blindness (HP:0007642)3.55213389
9Amyotrophic lateral sclerosis (HP:0007354)3.50543739
10Hypoproteinemia (HP:0003075)3.41091120
11Hepatic necrosis (HP:0002605)3.37051431
12Elevated erythrocyte sedimentation rate (HP:0003565)3.16978971
13Renal cortical cysts (HP:0000803)3.04393425
14Mitochondrial inheritance (HP:0001427)3.02852051
15True hermaphroditism (HP:0010459)2.94075878
16Pancreatic fibrosis (HP:0100732)2.93490386
17Abnormality of midbrain morphology (HP:0002418)2.91404010
18Molar tooth sign on MRI (HP:0002419)2.91404010
19Abnormality of the renal cortex (HP:0011035)2.85512347
20Pancreatic cysts (HP:0001737)2.85306895
213-Methylglutaconic aciduria (HP:0003535)2.73847729
22Medial flaring of the eyebrow (HP:0010747)2.71206595
23Increased intramyocellular lipid droplets (HP:0012240)2.70884532
24Increased serum lactate (HP:0002151)2.69056775
25Increased CSF lactate (HP:0002490)2.66696831
26Nephronophthisis (HP:0000090)2.66673437
27Recurrent bronchitis (HP:0002837)2.65657450
28Generalized aminoaciduria (HP:0002909)2.63115464
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60488434
30Abnormality of alanine metabolism (HP:0010916)2.60488434
31Hyperalaninemia (HP:0003348)2.60488434
32Abolished electroretinogram (ERG) (HP:0000550)2.60044057
33IgM deficiency (HP:0002850)2.54033916
34Abnormality of the proximal phalanges of the hand (HP:0009834)2.51431739
35Renal Fanconi syndrome (HP:0001994)2.48350938
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.47600596
37Absent/shortened dynein arms (HP:0200106)2.47600596
38Severe combined immunodeficiency (HP:0004430)2.46762630
39Abnormal albumin level (HP:0012116)2.43705377
40Hypoalbuminemia (HP:0003073)2.43705377
41Autoimmune hemolytic anemia (HP:0001890)2.43603988
42Abnormality of T cells (HP:0002843)2.42186089
43Facial diplegia (HP:0001349)2.41171738
44Chronic diarrhea (HP:0002028)2.38685831
45Thyroiditis (HP:0100646)2.34753116
46Increased IgM level (HP:0003496)2.33887280
47Colon cancer (HP:0003003)2.30851762
48Abnormality of the renal medulla (HP:0100957)2.28322354
49Abnormal mitochondria in muscle tissue (HP:0008316)2.27198172
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26522926
51Supernumerary spleens (HP:0009799)2.25748385
52Congenital primary aphakia (HP:0007707)2.25660345
53Chronic hepatic failure (HP:0100626)2.25626315
54Agammaglobulinemia (HP:0004432)2.24802493
55Acute hepatic failure (HP:0006554)2.24236025
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23770029
57Abnormality of male internal genitalia (HP:0000022)2.19979758
58Polydipsia (HP:0001959)2.19196910
59Abnormal drinking behavior (HP:0030082)2.19196910
60Autoimmune thrombocytopenia (HP:0001973)2.16179488
61Bronchitis (HP:0012387)2.15414976
62Anhidrosis (HP:0000970)2.13884952
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.13875638
64Gait imbalance (HP:0002141)2.13833977
65Hypoplasia of the uterus (HP:0000013)2.13269974
66Acute necrotizing encephalopathy (HP:0006965)2.10551085
67Cellular immunodeficiency (HP:0005374)2.08190462
68Pancytopenia (HP:0001876)2.06102772
69Premature graying of hair (HP:0002216)1.96678826
70Nephrogenic diabetes insipidus (HP:0009806)1.96649512
71Abnormal spermatogenesis (HP:0008669)1.95538662
72Increased muscle lipid content (HP:0009058)1.95273462
73Stomach cancer (HP:0012126)1.95128803
74Abnormality of B cell number (HP:0010975)1.94291197
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93994299
76Tongue fasciculations (HP:0001308)1.91478502
77Encephalitis (HP:0002383)1.91001542
78Tubulointerstitial nephritis (HP:0001970)1.90021177
79Abnormal protein glycosylation (HP:0012346)1.89277847
80Abnormal glycosylation (HP:0012345)1.89277847
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89277847
82Abnormal protein N-linked glycosylation (HP:0012347)1.89277847
83Oral leukoplakia (HP:0002745)1.89195776
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86726270
85Chronic sinusitis (HP:0011109)1.85077233
86Abnormality of urine glucose concentration (HP:0011016)1.85056950
87Glycosuria (HP:0003076)1.85056950
88Attenuation of retinal blood vessels (HP:0007843)1.84653479
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.83761859
90Lactic acidosis (HP:0003128)1.82625584
91Tubular atrophy (HP:0000092)1.81627975
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81057066
93Genital tract atresia (HP:0001827)1.80464185
94Nemaline bodies (HP:0003798)1.79205720
95Combined immunodeficiency (HP:0005387)1.77131850
96Abnormal respiratory motile cilium physiology (HP:0012261)1.76987582
97Type I transferrin isoform profile (HP:0003642)1.76184666
98Glucose intolerance (HP:0000833)1.75929157
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74570951
100Conical tooth (HP:0000698)1.74134935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK28.17938718
2KDR4.96101003
3GRK13.10203363
4ZAK3.02887550
5VRK22.56498169
6FRK2.55697593
7BCKDK2.48694550
8TLK12.27870019
9MUSK2.10401472
10TESK12.06638813
11TIE11.97140330
12STK161.94927597
13ITK1.91230753
14NUAK11.80152831
15TAOK31.79540530
16MAPKAPK31.79104717
17VRK11.74054057
18LIMK11.73745033
19TEC1.55197517
20TXK1.52970575
21EIF2AK31.52635893
22EIF2AK11.48476252
23SCYL21.47855658
24MAP4K11.46980973
25ACVR1B1.44898073
26PIK3CA1.33162588
27MAP3K121.30557421
28WNK31.16180405
29ADRBK21.13762275
30SYK1.11457384
31TNIK1.03201441
32BMPR1B1.00003662
33BRSK20.97948511
34DAPK10.95999333
35ERBB30.93683571
36MAP4K20.88975278
37TRPM70.84833614
38TNK20.84274498
39CAMKK20.79801955
40OBSCN0.76120110
41MYLK0.75992882
42IKBKE0.70935684
43AKT30.69509066
44LCK0.68904442
45PIK3CG0.68903780
46TBK10.67337762
47CSNK1A1L0.63683328
48CSNK1G30.63562425
49PRKD30.61159701
50PRKCQ0.60161805
51MAPK130.59230773
52BLK0.59218251
53BMPR20.58740619
54GRK70.57231173
55ROCK10.56598174
56BTK0.56402524
57INSRR0.55746481
58CAMK1D0.54525521
59CSNK1G10.54135948
60MST40.52892682
61IKBKB0.52249016
62ADRBK10.50794955
63WNK40.49185246
64LYN0.48745400
65MAPKAPK50.47503679
66GRK50.46198318
67FES0.44523674
68MAPKAPK20.44055403
69PTK2B0.43871263
70PLK40.43476030
71BUB10.43209583
72RPS6KA50.42845178
73TGFBR20.41586256
74IGF1R0.41512462
75MAP3K110.41494686
76CSK0.40524855
77PDK20.40509728
78GRK60.40216832
79EIF2AK20.39386846
80ZAP700.36413967
81AURKA0.35021652
82CHEK20.33829726
83PLK20.33755660
84HCK0.33531498
85CSNK1G20.31134094
86NEK10.30776362
87PRKACA0.29928213
88PLK30.29403504
89CHUK0.29095265
90ATR0.28954520
91AURKB0.28806448
92CSNK1A10.28163226
93INSR0.26880397
94TAF10.26142669
95PRKCA0.25147218
96PRKAA20.24439392
97TGFBR10.24092193
98FYN0.23575768
99MKNK20.22924457
100MAP3K140.21849199

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.55823197
2Primary immunodeficiency_Homo sapiens_hsa053404.07448896
3Proteasome_Homo sapiens_hsa030504.04740863
4Sulfur metabolism_Homo sapiens_hsa009202.59352205
5Graft-versus-host disease_Homo sapiens_hsa053322.50586184
6Antigen processing and presentation_Homo sapiens_hsa046122.35265416
7Protein export_Homo sapiens_hsa030602.33214080
8Autoimmune thyroid disease_Homo sapiens_hsa053202.32589197
9Allograft rejection_Homo sapiens_hsa053302.30876329
10Phototransduction_Homo sapiens_hsa047442.21707908
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11002355
12Oxidative phosphorylation_Homo sapiens_hsa001902.00517146
13Hematopoietic cell lineage_Homo sapiens_hsa046401.99624111
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.86961333
15Type I diabetes mellitus_Homo sapiens_hsa049401.81681672
16Parkinsons disease_Homo sapiens_hsa050121.66525750
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64090832
18RNA polymerase_Homo sapiens_hsa030201.63491364
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57029718
20Selenocompound metabolism_Homo sapiens_hsa004501.53738329
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51472073
22Linoleic acid metabolism_Homo sapiens_hsa005911.46902700
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42870801
24Asthma_Homo sapiens_hsa053101.40207952
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.36612285
26Chemical carcinogenesis_Homo sapiens_hsa052041.26497286
27Tryptophan metabolism_Homo sapiens_hsa003801.24329318
28Huntingtons disease_Homo sapiens_hsa050161.18216899
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17700665
30Rheumatoid arthritis_Homo sapiens_hsa053231.17308950
31Pancreatic secretion_Homo sapiens_hsa049721.16395823
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09122840
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07936640
34Fat digestion and absorption_Homo sapiens_hsa049751.07501974
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05878071
36Fanconi anemia pathway_Homo sapiens_hsa034601.05640998
37Nitrogen metabolism_Homo sapiens_hsa009101.00664936
38Butanoate metabolism_Homo sapiens_hsa006501.00336370
39RNA degradation_Homo sapiens_hsa030181.00012069
40Systemic lupus erythematosus_Homo sapiens_hsa053220.99620668
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98045654
42T cell receptor signaling pathway_Homo sapiens_hsa046600.96783111
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94969465
44One carbon pool by folate_Homo sapiens_hsa006700.94747606
45Propanoate metabolism_Homo sapiens_hsa006400.93337471
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93061390
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.92276684
48Steroid biosynthesis_Homo sapiens_hsa001000.91104112
49Regulation of autophagy_Homo sapiens_hsa041400.90886417
50Alzheimers disease_Homo sapiens_hsa050100.89467063
51Peroxisome_Homo sapiens_hsa041460.89359966
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89140367
53Cardiac muscle contraction_Homo sapiens_hsa042600.87870188
54Retinol metabolism_Homo sapiens_hsa008300.87280979
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84685441
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83753128
57Non-homologous end-joining_Homo sapiens_hsa034500.82185523
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.81496816
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.81302878
60Purine metabolism_Homo sapiens_hsa002300.81282418
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80788845
62Shigellosis_Homo sapiens_hsa051310.80635655
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80262786
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77751105
65Arachidonic acid metabolism_Homo sapiens_hsa005900.77603002
66Pyrimidine metabolism_Homo sapiens_hsa002400.75990868
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68010845
68Renin-angiotensin system_Homo sapiens_hsa046140.67637823
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67447162
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.67344819
71Homologous recombination_Homo sapiens_hsa034400.62974629
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61003657
73Herpes simplex infection_Homo sapiens_hsa051680.58667270
74Basal transcription factors_Homo sapiens_hsa030220.56155467
75Viral myocarditis_Homo sapiens_hsa054160.54182088
76Measles_Homo sapiens_hsa051620.50711700
77Metabolic pathways_Homo sapiens_hsa011000.50282569
78Ether lipid metabolism_Homo sapiens_hsa005650.48377258
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.47573602
80Circadian rhythm_Homo sapiens_hsa047100.47284222
81Protein digestion and absorption_Homo sapiens_hsa049740.46736907
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43830109
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42834011
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40932166
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40503382
86Olfactory transduction_Homo sapiens_hsa047400.39275434
87Fatty acid elongation_Homo sapiens_hsa000620.39256034
88N-Glycan biosynthesis_Homo sapiens_hsa005100.38306036
89Glycerolipid metabolism_Homo sapiens_hsa005610.37353818
90Sulfur relay system_Homo sapiens_hsa041220.36588287
91Mismatch repair_Homo sapiens_hsa034300.33666359
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32668992
93Vitamin digestion and absorption_Homo sapiens_hsa049770.32153169
94Starch and sucrose metabolism_Homo sapiens_hsa005000.31676444
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.31144792
96Lysosome_Homo sapiens_hsa041420.30494669
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29500732
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25884680
99Staphylococcus aureus infection_Homo sapiens_hsa051500.24138263
100Fatty acid degradation_Homo sapiens_hsa000710.23029237

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