TPM3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)8.46070563
2DNA unwinding involved in DNA replication (GO:0006268)8.12618048
3tryptophan catabolic process (GO:0006569)8.01734525
4indole-containing compound catabolic process (GO:0042436)8.01734525
5indolalkylamine catabolic process (GO:0046218)8.01734525
6kynurenine metabolic process (GO:0070189)7.77082689
7negative regulation of DNA-templated transcription, elongation (GO:0032785)7.19935967
8tryptophan metabolic process (GO:0006568)7.05887649
9terpenoid biosynthetic process (GO:0016114)6.59281269
10diterpenoid biosynthetic process (GO:0016102)6.24894943
11indolalkylamine metabolic process (GO:0006586)5.33025729
12lysine metabolic process (GO:0006553)5.11592253
13lysine catabolic process (GO:0006554)5.11592253
14embryonic camera-type eye development (GO:0031076)5.10870314
15regulation of cilium movement (GO:0003352)4.89140293
16cellular biogenic amine catabolic process (GO:0042402)4.80257118
17amine catabolic process (GO:0009310)4.80257118
18negative regulation of cAMP-mediated signaling (GO:0043951)4.74468339
19regulation of microtubule-based movement (GO:0060632)4.67242178
20positive regulation of circadian rhythm (GO:0042753)4.53401095
21DNA strand elongation involved in DNA replication (GO:0006271)4.51157896
22aromatic amino acid family catabolic process (GO:0009074)4.38462691
23autophagic vacuole fusion (GO:0000046)4.33093220
24DNA strand elongation (GO:0022616)4.18418615
25regulation of inclusion body assembly (GO:0090083)4.13847702
26organelle membrane fusion (GO:0090174)4.13799306
27regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)4.01452683
28cAMP catabolic process (GO:0006198)4.00817260
29histone H2B ubiquitination (GO:0033523)3.86391761
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.83037770
31isotype switching (GO:0045190)3.83037770
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.83037770
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62957926
34DNA replication initiation (GO:0006270)3.59719109
35regulation of memory T cell differentiation (GO:0043380)3.52970580
36positive regulation of histone H3-K4 methylation (GO:0051571)3.52783736
37DNA deamination (GO:0045006)3.52130689
38DNA catabolic process, exonucleolytic (GO:0000738)3.51240558
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.45081350
40nucleotide transmembrane transport (GO:1901679)3.43770561
41indole-containing compound metabolic process (GO:0042430)3.43169126
42benzene-containing compound metabolic process (GO:0042537)3.41898410
43aspartate family amino acid catabolic process (GO:0009068)3.40863952
44alternative mRNA splicing, via spliceosome (GO:0000380)3.40364238
45mammary gland epithelial cell proliferation (GO:0033598)3.34001874
46cyclic nucleotide catabolic process (GO:0009214)3.31270198
47morphogenesis of an epithelial fold (GO:0060571)3.30766410
48negative regulation of epidermal cell differentiation (GO:0045605)3.28471083
49hypotonic response (GO:0006971)3.26250839
50L-fucose catabolic process (GO:0042355)3.25570828
51fucose catabolic process (GO:0019317)3.25570828
52L-fucose metabolic process (GO:0042354)3.25570828
53SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.25549690
54regulation of timing of cell differentiation (GO:0048505)3.25477036
55response to folic acid (GO:0051593)3.22054119
56response to misfolded protein (GO:0051788)3.21319624
57cell fate commitment involved in formation of primary germ layer (GO:0060795)3.18075389
58retinal metabolic process (GO:0042574)3.17847303
59positive regulation of DNA repair (GO:0045739)3.13783982
60organ formation (GO:0048645)3.08086316
61protein K11-linked deubiquitination (GO:0035871)3.07815614
62non-recombinational repair (GO:0000726)3.07554157
63double-strand break repair via nonhomologous end joining (GO:0006303)3.07554157
64negative regulation of reactive oxygen species metabolic process (GO:2000378)3.05476790
65phosphorelay signal transduction system (GO:0000160)3.04215183
66negative regulation of potassium ion transmembrane transport (GO:1901380)2.98910910
67acrosome reaction (GO:0007340)2.98352682
68cytochrome complex assembly (GO:0017004)2.97514956
69regulation of development, heterochronic (GO:0040034)2.97210388
70piRNA metabolic process (GO:0034587)2.96408681
71mitotic sister chromatid segregation (GO:0000070)2.95474817
72Golgi to endosome transport (GO:0006895)2.94798678
73aromatic amino acid family metabolic process (GO:0009072)2.94072502
74positive regulation of cAMP-mediated signaling (GO:0043950)2.92315096
75positive regulation of prostaglandin secretion (GO:0032308)2.87925970
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87127638
77mannosylation (GO:0097502)2.86956477
78histone mRNA catabolic process (GO:0071044)2.86395635
79positive regulation of defense response to virus by host (GO:0002230)2.84533681
80ganglion development (GO:0061548)2.79057889
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77356275
82protein-cofactor linkage (GO:0018065)2.72990283
83lateral sprouting from an epithelium (GO:0060601)2.72851564
84regulation of hydrogen peroxide metabolic process (GO:0010310)2.71065194
85type B pancreatic cell proliferation (GO:0044342)2.71058578
86oxidative phosphorylation (GO:0006119)2.70289859
87negative regulation of smoothened signaling pathway (GO:0045879)2.69165928
88histone H2A ubiquitination (GO:0033522)2.68261974
89preassembly of GPI anchor in ER membrane (GO:0016254)2.68164803
90regulation of prostaglandin secretion (GO:0032306)2.68121863
91respiratory chain complex IV assembly (GO:0008535)2.63723025
92mitochondrial DNA replication (GO:0006264)2.60783412
93branch elongation of an epithelium (GO:0060602)2.56652538
94retinol metabolic process (GO:0042572)2.56517172
95macroautophagy (GO:0016236)2.53448210
96retina layer formation (GO:0010842)2.53360595
97magnesium ion transport (GO:0015693)2.52986726
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52117202
99somite development (GO:0061053)2.48127754
100recombinational repair (GO:0000725)2.47707424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14457605
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.45215054
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.77407043
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.42742743
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.40214131
6ZNF274_21170338_ChIP-Seq_K562_Hela2.86108812
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.64461412
8PCGF2_27294783_Chip-Seq_NPCs_Mouse2.54927964
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.33980729
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.32617718
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18259471
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15404913
13VDR_22108803_ChIP-Seq_LS180_Human2.11762173
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08081335
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.05614413
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04494777
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99653915
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95328453
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94921851
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91524155
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86446219
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78971727
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.77728708
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.75060532
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74071443
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.62819120
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60669088
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58378012
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.54091809
30CIITA_25753668_ChIP-Seq_RAJI_Human1.50776787
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.48388368
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44840611
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43573004
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.41544852
35VDR_23849224_ChIP-Seq_CD4+_Human1.40543801
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37982195
37TP53_22573176_ChIP-Seq_HFKS_Human1.37169713
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36718647
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36348386
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.33612125
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.30201544
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28626604
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.28567377
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28567377
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25959422
46RUNX_20019798_ChIP-Seq_JUKART_Human1.25305725
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22779988
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22485040
49MYC_18940864_ChIP-ChIP_HL60_Human1.22071566
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18872877
51IGF1R_20145208_ChIP-Seq_DFB_Human1.18627474
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.18619539
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18247297
54FOXP3_21729870_ChIP-Seq_TREG_Human1.16135961
55PHF8_20622853_ChIP-Seq_HELA_Human1.15489769
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14867432
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.12425225
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.11303880
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10396018
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10199333
61EWS_26573619_Chip-Seq_HEK293_Human1.09810865
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09561324
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.08987737
64NCOR_22424771_ChIP-Seq_293T_Human1.08525256
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08486373
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08086901
67KLF4_18555785_Chip-Seq_ESCs_Mouse1.06988604
68ETV1_20927104_ChIP-Seq_GIST48_Human1.06686343
69HNFA_21074721_ChIP-Seq_CACO-2_Human1.06365087
70GATA3_27048872_Chip-Seq_THYMUS_Human1.04510758
71FUS_26573619_Chip-Seq_HEK293_Human1.04437022
72SCL_19346495_ChIP-Seq_HPC-7_Human1.02926498
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.01022722
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.00588372
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00147555
76RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99380981
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99028049
78NFYA_21822215_ChIP-Seq_K562_Human0.98961922
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98718869
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98642355
81SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98575133
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.97624787
83NANOG_20526341_ChIP-Seq_ESCs_Human0.96321229
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96008806
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95944893
86OCT4_20526341_ChIP-Seq_ESCs_Human0.95587690
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95120920
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94765737
89P53_22387025_ChIP-Seq_ESCs_Mouse0.94380202
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93751798
91GATA3_26560356_Chip-Seq_TH1_Human0.93067746
92ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92670291
93RBPJ_21746931_ChIP-Seq_IB4_Human0.92014398
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.91936059
95ELK1_19687146_ChIP-ChIP_HELA_Human0.91785272
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91626367
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91555498
98NFYB_21822215_ChIP-Seq_K562_Human0.90904298
99HOXB7_26014856_ChIP-Seq_BT474_Human0.90368142
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88783830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.40312955
2MP0008875_abnormal_xenobiotic_pharmacok3.35449099
3MP0003011_delayed_dark_adaptation2.98749364
4MP0010094_abnormal_chromosome_stability2.97948059
5MP0003172_abnormal_lysosome_physiology2.87095385
6MP0004215_abnormal_myocardial_fiber2.42737163
7MP0003763_abnormal_thymus_physiology2.34777314
8MP0008260_abnormal_autophagy2.34409423
9MP0003786_premature_aging2.30842507
10MP0004147_increased_porphyrin_level2.16610599
11MP0006072_abnormal_retinal_apoptosis1.92188757
12MP0005645_abnormal_hypothalamus_physiol1.90253278
13MP0005671_abnormal_response_to1.89051618
14MP0008877_abnormal_DNA_methylation1.88432005
15MP0002876_abnormal_thyroid_physiology1.78390520
16MP0001984_abnormal_olfaction1.77775578
17MP0005379_endocrine/exocrine_gland_phen1.73080134
18MP0000013_abnormal_adipose_tissue1.71208920
19MP0002909_abnormal_adrenal_gland1.71143244
20MP0003111_abnormal_nucleus_morphology1.68394901
21MP0008058_abnormal_DNA_repair1.67740952
22MP0000538_abnormal_urinary_bladder1.67629144
23MP0000358_abnormal_cell_content/1.66259688
24MP0006035_abnormal_mitochondrial_morpho1.61251719
25MP0003646_muscle_fatigue1.57291600
26MP0005167_abnormal_blood-brain_barrier1.48694402
27MP0001835_abnormal_antigen_presentation1.47227054
28MP0002102_abnormal_ear_morphology1.46805133
29MP0002733_abnormal_thermal_nociception1.45534626
30MP0006276_abnormal_autonomic_nervous1.38941102
31MP0005646_abnormal_pituitary_gland1.38479597
32MP0005253_abnormal_eye_physiology1.38114246
33MP0003186_abnormal_redox_activity1.34791350
34MP0001800_abnormal_humoral_immune1.32420714
35MP0000631_abnormal_neuroendocrine_gland1.30018054
36MP0005551_abnormal_eye_electrophysiolog1.28576535
37MP0008872_abnormal_physiological_respon1.25282884
38MP0005058_abnormal_lysosome_morphology1.22105055
39MP0001958_emphysema1.21584462
40MP0009764_decreased_sensitivity_to1.20319258
41MP0004043_abnormal_pH_regulation1.19600131
42MP0001501_abnormal_sleep_pattern1.17264530
43MP0001440_abnormal_grooming_behavior1.17226816
44MP0002210_abnormal_sex_determination1.12122742
45MP0003638_abnormal_response/metabolism_1.09950396
46MP0003878_abnormal_ear_physiology1.09601127
47MP0005377_hearing/vestibular/ear_phenot1.09601127
48MP0008057_abnormal_DNA_replication1.07956250
49MP0001727_abnormal_embryo_implantation1.07534864
50MP0001529_abnormal_vocalization1.05568076
51MP0003938_abnormal_ear_development1.01967781
52MP0010386_abnormal_urinary_bladder1.01800270
53MP0002148_abnormal_hypersensitivity_rea1.01045417
54MP0000639_abnormal_adrenal_gland1.00657688
55MP0000230_abnormal_systemic_arterial0.98417342
56MP0001905_abnormal_dopamine_level0.97083808
57MP0003724_increased_susceptibility_to0.97055626
58MP0003937_abnormal_limbs/digits/tail_de0.96555723
59MP0004142_abnormal_muscle_tone0.95236437
60MP0002067_abnormal_sensory_capabilities0.90880902
61MP0001968_abnormal_touch/_nociception0.89698689
62MP0001929_abnormal_gametogenesis0.89506695
63MP0002006_tumorigenesis0.89329044
64MP0002163_abnormal_gland_morphology0.88971112
65MP0004145_abnormal_muscle_electrophysio0.87852833
66MP0002837_dystrophic_cardiac_calcinosis0.87509654
67MP0000015_abnormal_ear_pigmentation0.87234135
68MP0005410_abnormal_fertilization0.86883706
69MP0008789_abnormal_olfactory_epithelium0.86499118
70MP0002095_abnormal_skin_pigmentation0.84206328
71MP0002166_altered_tumor_susceptibility0.81933398
72MP0009384_cardiac_valve_regurgitation0.81214314
73MP0005319_abnormal_enzyme/_coenzyme0.80130725
74MP0001970_abnormal_pain_threshold0.79876066
75MP0002723_abnormal_immune_serum0.79063035
76MP0002452_abnormal_antigen_presenting0.76903841
77MP0000372_irregular_coat_pigmentation0.75420068
78MP0010329_abnormal_lipoprotein_level0.74662352
79MP0002638_abnormal_pupillary_reflex0.71970425
80MP0003136_yellow_coat_color0.71930858
81MP0000566_synostosis0.71382432
82MP0002736_abnormal_nociception_after0.69736323
83MP0002420_abnormal_adaptive_immunity0.68734050
84MP0000689_abnormal_spleen_morphology0.68366569
85MP0004924_abnormal_behavior0.68275333
86MP0005386_behavior/neurological_phenoty0.68275333
87MP0002277_abnormal_respiratory_mucosa0.67643863
88MP0005174_abnormal_tail_pigmentation0.67152587
89MP0001765_abnormal_ion_homeostasis0.66785886
90MP0002115_abnormal_skeleton_extremities0.66739992
91MP0008770_decreased_survivor_rate0.66581239
92MP0001270_distended_abdomen0.66457733
93MP0001819_abnormal_immune_cell0.65787044
94MP0000427_abnormal_hair_cycle0.64657260
95MP0003698_abnormal_male_reproductive0.63105292
96MP0008873_increased_physiological_sensi0.62902524
97MP0006138_congestive_heart_failure0.62734730
98MP0005000_abnormal_immune_tolerance0.62442632
99MP0005332_abnormal_amino_acid0.62163332
100MP0000653_abnormal_sex_gland0.59793425

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)5.38030041
2Poor speech (HP:0002465)4.65699339
3Abnormality of lateral ventricle (HP:0030047)4.59112992
4Conical tooth (HP:0000698)4.05560665
5Morphological abnormality of the inner ear (HP:0011390)3.98755848
6IgG deficiency (HP:0004315)3.93328300
7Abnormality of the proximal phalanges of the hand (HP:0009834)3.87705711
8Absent hand (HP:0004050)3.47601218
9Tongue fasciculations (HP:0001308)3.44771981
103-Methylglutaconic aciduria (HP:0003535)3.39424359
11Hypoplasia of the capital femoral epiphysis (HP:0003090)3.32475381
12Tetraparesis (HP:0002273)3.13346097
13Flat capital femoral epiphysis (HP:0003370)3.10503440
14Hypoplastic iliac wings (HP:0002866)3.10270900
15Abnormality of the phalanges of the 2nd finger (HP:0009541)2.91874623
16Diastasis recti (HP:0001540)2.91821906
17Abnormality of the renal cortex (HP:0011035)2.88469863
18Muscle fibrillation (HP:0010546)2.87673928
19Chin dimple (HP:0010751)2.84871520
20Deep palmar crease (HP:0006191)2.83697611
21Progressive inability to walk (HP:0002505)2.83492187
22Calcaneovalgus deformity (HP:0001848)2.82437727
23Absent septum pellucidum (HP:0001331)2.79463283
24Absent epiphyses (HP:0010577)2.71962555
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.71962555
26Nephronophthisis (HP:0000090)2.71230455
27Congenital stationary night blindness (HP:0007642)2.66869325
28Deformed tarsal bones (HP:0008119)2.62914409
29Abnormality of the labia minora (HP:0012880)2.62299573
30Acute myeloid leukemia (HP:0004808)2.56211423
31Mitochondrial inheritance (HP:0001427)2.54890936
32Large eyes (HP:0001090)2.54833296
3311 pairs of ribs (HP:0000878)2.54652590
34Carpal bone hypoplasia (HP:0001498)2.54555582
35Optic nerve hypoplasia (HP:0000609)2.53113331
36Type II lissencephaly (HP:0007260)2.49832335
37Severe muscular hypotonia (HP:0006829)2.46947922
38Sensory axonal neuropathy (HP:0003390)2.42235251
39Stomatitis (HP:0010280)2.39454445
40Abnormality of the fingertips (HP:0001211)2.39240340
41Severe visual impairment (HP:0001141)2.34926856
42Abnormality of the renal medulla (HP:0100957)2.30726201
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29412595
44Spastic paraparesis (HP:0002313)2.25662622
45Type I transferrin isoform profile (HP:0003642)2.24714633
46Abnormality of the calcaneus (HP:0008364)2.24679304
47Hyperglycinuria (HP:0003108)2.24136741
48Pustule (HP:0200039)2.23782780
49Hepatic necrosis (HP:0002605)2.16870607
50Abnormality of the septum pellucidum (HP:0007375)2.16655973
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13967748
52Aplasia/hypoplasia of the uterus (HP:0008684)2.13504974
53Cerebellar dysplasia (HP:0007033)2.13165438
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12666912
55Abnormality of midbrain morphology (HP:0002418)2.11431250
56Molar tooth sign on MRI (HP:0002419)2.11431250
57Ketoacidosis (HP:0001993)2.09668464
58Renal cortical cysts (HP:0000803)2.09607243
59Medial flaring of the eyebrow (HP:0010747)2.08708739
60Small epiphyses (HP:0010585)2.08502336
61Mutism (HP:0002300)2.07787982
62Facial cleft (HP:0002006)2.07250121
63Stomach cancer (HP:0012126)2.06575272
64Type 2 muscle fiber atrophy (HP:0003554)2.02581135
65Vacuolated lymphocytes (HP:0001922)2.02297626
66Abolished electroretinogram (ERG) (HP:0000550)1.95602647
67Attenuation of retinal blood vessels (HP:0007843)1.92360866
68Overlapping toe (HP:0001845)1.90098129
69Hepatocellular necrosis (HP:0001404)1.89674069
70Abnormality of eosinophils (HP:0001879)1.89345567
71Erythema (HP:0010783)1.88129388
72True hermaphroditism (HP:0010459)1.87328202
73Tubulointerstitial fibrosis (HP:0005576)1.86839398
74Congenital sensorineural hearing impairment (HP:0008527)1.86524300
75Abnormality of the middle phalanges of the toes (HP:0010183)1.86186708
76Pancreatic cysts (HP:0001737)1.86105851
77Paraparesis (HP:0002385)1.82977460
78Muscle fiber atrophy (HP:0100295)1.82305079
79Inability to walk (HP:0002540)1.81875819
80Brittle hair (HP:0002299)1.80813276
81Hypoplasia of the pons (HP:0012110)1.80098214
82T lymphocytopenia (HP:0005403)1.78789827
83CNS hypomyelination (HP:0003429)1.78573125
84Generalized aminoaciduria (HP:0002909)1.78056816
85Broad distal phalanx of finger (HP:0009836)1.76059402
86Tracheomalacia (HP:0002779)1.75968183
87Hypergonadotropic hypogonadism (HP:0000815)1.75542338
88Agammaglobulinemia (HP:0004432)1.75216903
89Increased serum lactate (HP:0002151)1.73884206
90Opisthotonus (HP:0002179)1.73755211
91Panhypogammaglobulinemia (HP:0003139)1.73628532
92Abnormality of macular pigmentation (HP:0008002)1.72940406
93Abnormality of T cells (HP:0002843)1.72604836
94Menstrual irregularities (HP:0000858)1.70257821
95Disinhibition (HP:0000734)1.69005105
96Eosinophilia (HP:0001880)1.68831352
97Patellar aplasia (HP:0006443)1.66918825
98Congenital, generalized hypertrichosis (HP:0004540)1.65990536
99Vertebral arch anomaly (HP:0008438)1.65770864
100Gaze-evoked nystagmus (HP:0000640)1.65459301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.69946683
2STK38L7.21680193
3ZAK3.54922156
4BLK3.20885972
5TXK3.12755624
6CDC72.91475466
7EIF2AK12.70102601
8WNK12.20882725
9STK381.97122537
10BMPR1B1.86738449
11PHKG11.85652884
12PHKG21.85652884
13MAP4K21.68369990
14ZAP701.63527970
15KIT1.54193711
16PINK11.48183620
17MAP4K11.41798550
18FRK1.41484421
19MST41.29000558
20TLK11.21748955
21EPHA21.16537437
22ADRBK21.14184754
23SYK1.08450698
24FES1.06170641
25BRSK20.99916455
26CSNK1G30.96814579
27TESK20.95500120
28GRK10.94738280
29NUAK10.94211851
30CSNK1A1L0.88582996
31CSF1R0.87743017
32CDK80.86893007
33CSNK1G20.86800979
34KDR0.86386922
35TGFBR10.86377249
36CDK190.83985410
37MAPKAPK50.83745838
38IKBKB0.81558950
39VRK10.80714342
40MKNK10.78349870
41NEK10.77909800
42BCKDK0.76767572
43CSNK1G10.75790481
44MAPKAPK30.75190713
45LYN0.74813116
46IKBKE0.72535916
47ITK0.72398727
48TAF10.71372873
49TIE10.69818761
50CDK30.65522605
51CHEK20.64209626
52CSNK1D0.63814487
53JAK30.60404177
54EIF2AK30.56547239
55PTK2B0.50545982
56TNK20.50197597
57MARK30.50186040
58LIMK10.46759713
59PAK60.46637087
60TEC0.45566403
61PLK30.44747152
62FLT30.44427347
63TESK10.43537597
64PLK20.40990679
65FGFR20.40874005
66WNK40.40219429
67EIF2AK20.39325804
68GRK50.38942932
69MAPK110.37920846
70DYRK20.37894043
71IGF1R0.37809363
72IRAK30.37408231
73NME10.37221960
74RPS6KA50.36343553
75STK390.34894236
76PRKG20.34387911
77INSRR0.34110788
78MAP2K20.33807917
79MAP3K140.30574517
80MAPK90.29899912
81PLK10.29463338
82CASK0.29426086
83MAP3K40.28293267
84LCK0.27851522
85OXSR10.27802212
86PRKG10.27354294
87FYN0.25368149
88PRKACB0.25048230
89CSNK2A10.23575296
90ATR0.22944623
91VRK20.21973253
92JAK20.21689583
93OBSCN0.20885674
94ATM0.20817479
95ADRBK10.20530540
96EPHA40.20347630
97NEK60.19668584
98ABL10.19520688
99MAPK80.19285150
100MAPK130.19278696

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.61441820
2DNA replication_Homo sapiens_hsa030303.46605512
3Tryptophan metabolism_Homo sapiens_hsa003803.34484464
4Proteasome_Homo sapiens_hsa030503.18482152
5Nitrogen metabolism_Homo sapiens_hsa009102.41705248
6Selenocompound metabolism_Homo sapiens_hsa004502.36982553
7Phototransduction_Homo sapiens_hsa047442.31602750
8Primary immunodeficiency_Homo sapiens_hsa053402.26621695
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88613854
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.85902149
11SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84990451
12Linoleic acid metabolism_Homo sapiens_hsa005911.75435432
13Circadian rhythm_Homo sapiens_hsa047101.73054132
14Regulation of autophagy_Homo sapiens_hsa041401.71271854
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71106262
16Sulfur metabolism_Homo sapiens_hsa009201.60795342
17Non-homologous end-joining_Homo sapiens_hsa034501.49211416
18Oxidative phosphorylation_Homo sapiens_hsa001901.40507583
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40136952
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38386282
21Fanconi anemia pathway_Homo sapiens_hsa034601.37317355
22Retinol metabolism_Homo sapiens_hsa008301.36957513
23Sulfur relay system_Homo sapiens_hsa041221.29290927
24Chemical carcinogenesis_Homo sapiens_hsa052041.27706456
25Asthma_Homo sapiens_hsa053101.24568193
26Basal transcription factors_Homo sapiens_hsa030221.23573094
27Protein export_Homo sapiens_hsa030601.22521076
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22224558
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.21922565
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21836858
31Olfactory transduction_Homo sapiens_hsa047401.15699429
32Morphine addiction_Homo sapiens_hsa050321.13965342
33Mismatch repair_Homo sapiens_hsa034301.13886344
34Parkinsons disease_Homo sapiens_hsa050121.12431620
35RNA degradation_Homo sapiens_hsa030181.11085782
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05497126
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04238051
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04088808
39Antigen processing and presentation_Homo sapiens_hsa046121.02293436
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01540507
41Arachidonic acid metabolism_Homo sapiens_hsa005901.01521953
42Renin-angiotensin system_Homo sapiens_hsa046141.01289377
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99804086
44Allograft rejection_Homo sapiens_hsa053300.99515569
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97364285
46Starch and sucrose metabolism_Homo sapiens_hsa005000.97228217
47Autoimmune thyroid disease_Homo sapiens_hsa053200.96215116
48Peroxisome_Homo sapiens_hsa041460.96199035
49Cardiac muscle contraction_Homo sapiens_hsa042600.95756464
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93887695
51Homologous recombination_Homo sapiens_hsa034400.93680857
52Nucleotide excision repair_Homo sapiens_hsa034200.93497116
53Graft-versus-host disease_Homo sapiens_hsa053320.92930557
54Hedgehog signaling pathway_Homo sapiens_hsa043400.92899056
55Ether lipid metabolism_Homo sapiens_hsa005650.90679925
56RNA polymerase_Homo sapiens_hsa030200.85977598
57Lysine degradation_Homo sapiens_hsa003100.85775814
58Shigellosis_Homo sapiens_hsa051310.84379157
59Purine metabolism_Homo sapiens_hsa002300.77940401
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68952974
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67341492
62Protein digestion and absorption_Homo sapiens_hsa049740.67158995
63Huntingtons disease_Homo sapiens_hsa050160.66978986
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.65275071
65N-Glycan biosynthesis_Homo sapiens_hsa005100.64319541
66Propanoate metabolism_Homo sapiens_hsa006400.63383580
67Alzheimers disease_Homo sapiens_hsa050100.62309100
68Type I diabetes mellitus_Homo sapiens_hsa049400.62012869
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60515819
70Butanoate metabolism_Homo sapiens_hsa006500.60137674
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60042524
72Systemic lupus erythematosus_Homo sapiens_hsa053220.59111448
73Spliceosome_Homo sapiens_hsa030400.57352730
74Glycerolipid metabolism_Homo sapiens_hsa005610.56690314
75Rheumatoid arthritis_Homo sapiens_hsa053230.55214056
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54901208
77Metabolic pathways_Homo sapiens_hsa011000.53882603
78Pancreatic secretion_Homo sapiens_hsa049720.52096951
79Salivary secretion_Homo sapiens_hsa049700.49678024
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49393399
81Base excision repair_Homo sapiens_hsa034100.47493056
82Ovarian steroidogenesis_Homo sapiens_hsa049130.45811859
83ABC transporters_Homo sapiens_hsa020100.45747001
84Hematopoietic cell lineage_Homo sapiens_hsa046400.44404680
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.43185703
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43026237
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.42610613
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41846534
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39105148
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39041885
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36523470
92p53 signaling pathway_Homo sapiens_hsa041150.36231474
93Lysosome_Homo sapiens_hsa041420.35009958
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33666968
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.31424910
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30283891
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29663905
98Fat digestion and absorption_Homo sapiens_hsa049750.28353144
99Fatty acid degradation_Homo sapiens_hsa000710.25456252
100Taste transduction_Homo sapiens_hsa047420.25248158

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