TPM3P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.21958957
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.78169602
3rRNA modification (GO:0000154)5.85877991
4respiratory chain complex IV assembly (GO:0008535)5.76197025
5cytidine deamination (GO:0009972)5.43984116
6cytidine metabolic process (GO:0046087)5.43984116
7cytidine catabolic process (GO:0006216)5.43984116
8positive regulation of T cell differentiation in thymus (GO:0033089)5.05049794
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.99480331
10regulation of memory T cell differentiation (GO:0043380)4.94283103
11negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.89101958
12negative regulation of T-helper cell differentiation (GO:0045623)4.89101958
13rRNA methylation (GO:0031167)4.77135443
14maturation of 5.8S rRNA (GO:0000460)4.57568942
15cytochrome complex assembly (GO:0017004)4.55280185
16preassembly of GPI anchor in ER membrane (GO:0016254)4.45838302
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.43446808
18DNA catabolic process, exonucleolytic (GO:0000738)4.42906941
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32121845
20pseudouridine synthesis (GO:0001522)4.25493832
21positive regulation of isotype switching (GO:0045830)4.13434082
22regulation of regulatory T cell differentiation (GO:0045589)4.12682664
23short-chain fatty acid metabolic process (GO:0046459)4.09521984
24positive regulation of DNA recombination (GO:0045911)3.97027142
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.94544299
26regulation of T-helper 1 cell differentiation (GO:0045625)3.94033292
27DNA double-strand break processing (GO:0000729)3.89512881
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88021473
29ATP synthesis coupled proton transport (GO:0015986)3.88021473
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.87958430
31negative regulation of alpha-beta T cell differentiation (GO:0046639)3.82403087
32cellular response to interferon-beta (GO:0035458)3.78607113
33GPI anchor metabolic process (GO:0006505)3.60283900
34regulation of immunoglobulin secretion (GO:0051023)3.58873744
35negative regulation of mRNA processing (GO:0050686)3.57478671
36platelet dense granule organization (GO:0060155)3.55338646
37negative regulation of RNA splicing (GO:0033119)3.53836247
38water-soluble vitamin biosynthetic process (GO:0042364)3.41048793
39regulation of cilium movement (GO:0003352)3.38709947
40positive regulation of T cell cytokine production (GO:0002726)3.38709238
41establishment of integrated proviral latency (GO:0075713)3.32155159
42resolution of meiotic recombination intermediates (GO:0000712)3.31146943
43protein polyglutamylation (GO:0018095)3.29089302
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.26328116
45proteasome assembly (GO:0043248)3.25852324
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.21426098
47NADH dehydrogenase complex assembly (GO:0010257)3.21426098
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21426098
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.21423324
50mitochondrial respiratory chain complex assembly (GO:0033108)3.18781347
51GPI anchor biosynthetic process (GO:0006506)3.15847172
52protein complex biogenesis (GO:0070271)3.14427820
53autophagic vacuole fusion (GO:0000046)3.11437823
54response to pheromone (GO:0019236)3.10982349
55negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09221999
56adaptation of signaling pathway (GO:0023058)3.09154253
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03031965
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03031965
59amino acid activation (GO:0043038)3.00197652
60tRNA aminoacylation (GO:0043039)3.00197652
61tRNA aminoacylation for protein translation (GO:0006418)2.99392874
62regulation of translational elongation (GO:0006448)2.97890519
63glycine transport (GO:0015816)2.94934015
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91782934
65positive regulation of granulocyte differentiation (GO:0030854)2.89664888
66negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.87969988
67DNA demethylation (GO:0080111)2.87699608
68response to interferon-beta (GO:0035456)2.87339691
69protein neddylation (GO:0045116)2.86159292
70negative regulation of interleukin-17 production (GO:0032700)2.85262952
71kidney morphogenesis (GO:0060993)2.81327878
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80125037
73negative regulation of mRNA metabolic process (GO:1903312)2.78502936
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78256835
75isotype switching (GO:0045190)2.78256835
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78256835
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78132485
78regulation of mitochondrial translation (GO:0070129)2.77494294
79regulation of cellular amino acid metabolic process (GO:0006521)2.77123044
80proline transport (GO:0015824)2.77118995
81artery smooth muscle contraction (GO:0014824)2.76831404
82response to gravity (GO:0009629)2.75527147
83positive regulation of defense response to virus by host (GO:0002230)2.73556203
84mismatch repair (GO:0006298)2.72616779
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71334497
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70786212
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70786212
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69593602
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69593602
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69593602
91regulation of T cell receptor signaling pathway (GO:0050856)2.69272715
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68872809
93negative regulation of cell killing (GO:0031342)2.65784939
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65784939
95protein K6-linked ubiquitination (GO:0085020)2.65115174
96ER overload response (GO:0006983)2.64175059
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63533427
98positive regulation of growth hormone secretion (GO:0060124)2.61893662
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61099159
100negative regulation of telomere maintenance (GO:0032205)2.60044873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.68442514
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62632947
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82420455
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53182414
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13497339
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93118002
7ELK1_19687146_ChIP-ChIP_HELA_Human2.90460297
8VDR_22108803_ChIP-Seq_LS180_Human2.88054065
9FOXP3_21729870_ChIP-Seq_TREG_Human2.72852192
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69320866
11VDR_23849224_ChIP-Seq_CD4+_Human2.68206259
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.65711226
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63876754
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55027535
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54049279
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46885165
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43166346
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.28736504
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.15191694
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.08286919
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.02268946
22HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98315851
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96502305
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95566892
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95363818
26MYC_18940864_ChIP-ChIP_HL60_Human1.92355209
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88011575
28EWS_26573619_Chip-Seq_HEK293_Human1.87912497
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73277643
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71116762
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70761202
32GABP_19822575_ChIP-Seq_HepG2_Human1.70646013
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53392516
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51534096
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49086192
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.47826084
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47013619
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46781563
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46720888
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.45042804
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44514101
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43334119
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42506515
44TP53_22573176_ChIP-Seq_HFKS_Human1.41840192
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40758883
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40253847
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37644103
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37456424
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35556985
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35199204
51CBP_20019798_ChIP-Seq_JUKART_Human1.35188835
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35188835
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33980938
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.33348122
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33043297
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32693297
57IRF1_19129219_ChIP-ChIP_H3396_Human1.31684484
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22531443
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20545002
60DCP1A_22483619_ChIP-Seq_HELA_Human1.19117243
61HOXB7_26014856_ChIP-Seq_BT474_Human1.16444008
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15443418
63ER_23166858_ChIP-Seq_MCF-7_Human1.15420748
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11240709
65SOX2_19829295_ChIP-Seq_ESCs_Human1.10345840
66NANOG_19829295_ChIP-Seq_ESCs_Human1.10345840
67P300_19829295_ChIP-Seq_ESCs_Human1.08630987
68ELF5_23300383_ChIP-Seq_T47D_Human1.08342827
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07867806
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07728130
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07560103
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04424351
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.04424351
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03989530
75KDM5A_27292631_Chip-Seq_BREAST_Human1.03358836
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.03244662
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02526172
78TTF2_22483619_ChIP-Seq_HELA_Human1.01955468
79GATA3_26560356_Chip-Seq_TH2_Human1.01379808
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01001904
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98865461
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97340670
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96608649
84HTT_18923047_ChIP-ChIP_STHdh_Human0.96244583
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95165480
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94697479
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94140955
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93742068
89GBX2_23144817_ChIP-Seq_PC3_Human0.93716365
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93546246
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93384019
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93349287
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93204951
94CIITA_25753668_ChIP-Seq_RAJI_Human0.91565662
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89918955
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.88124858
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88075747
98AR_20517297_ChIP-Seq_VCAP_Human0.87926015
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87785750
100NCOR_22424771_ChIP-Seq_293T_Human0.85062355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.22964616
2MP0004147_increased_porphyrin_level4.11525148
3MP0003806_abnormal_nucleotide_metabolis4.06439384
4MP0001853_heart_inflammation3.23146291
5MP0002102_abnormal_ear_morphology2.83588627
6MP0005084_abnormal_gallbladder_morpholo2.75693731
7MP0008877_abnormal_DNA_methylation2.74500500
8MP0008058_abnormal_DNA_repair2.62506469
9MP0002254_reproductive_system_inflammat2.54700876
10MP0005671_abnormal_response_to2.27969493
11MP0008789_abnormal_olfactory_epithelium2.13153794
12MP0003646_muscle_fatigue2.11650731
13MP0001835_abnormal_antigen_presentation2.06927474
14MP0001727_abnormal_embryo_implantation1.95045168
15MP0005646_abnormal_pituitary_gland1.94857602
16MP0004381_abnormal_hair_follicle1.94513943
17MP0005167_abnormal_blood-brain_barrier1.87806662
18MP0005636_abnormal_mineral_homeostasis1.77574113
19MP0008057_abnormal_DNA_replication1.74318338
20MP0003186_abnormal_redox_activity1.73570526
21MP0002837_dystrophic_cardiac_calcinosis1.68243574
22MP0003693_abnormal_embryo_hatching1.65066439
23MP0001529_abnormal_vocalization1.62253126
24MP0005360_urolithiasis1.62134757
25MP0006072_abnormal_retinal_apoptosis1.61845709
26MP0005075_abnormal_melanosome_morpholog1.60206859
27MP0009780_abnormal_chondrocyte_physiolo1.55588464
28MP0002148_abnormal_hypersensitivity_rea1.53931813
29MP0002736_abnormal_nociception_after1.53354889
30MP0010094_abnormal_chromosome_stability1.52237041
31MP0003718_maternal_effect1.51890119
32MP0005085_abnormal_gallbladder_physiolo1.49695575
33MP0006036_abnormal_mitochondrial_physio1.49218976
34MP0002127_abnormal_cardiovascular_syste1.45523628
35MP0005551_abnormal_eye_electrophysiolog1.44729482
36MP0002938_white_spotting1.43612891
37MP0004957_abnormal_blastocyst_morpholog1.40924286
38MP0005253_abnormal_eye_physiology1.38576743
39MP0008007_abnormal_cellular_replicative1.38188000
40MP0003786_premature_aging1.37487109
41MP0003283_abnormal_digestive_organ1.35075410
42MP0002396_abnormal_hematopoietic_system1.31802205
43MP0005394_taste/olfaction_phenotype1.26450117
44MP0005499_abnormal_olfactory_system1.26450117
45MP0003077_abnormal_cell_cycle1.23992013
46MP0000516_abnormal_urinary_system1.22454571
47MP0005367_renal/urinary_system_phenotyp1.22454571
48MP0000689_abnormal_spleen_morphology1.21742594
49MP0001542_abnormal_bone_strength1.21334926
50MP0000372_irregular_coat_pigmentation1.19317338
51MP0006035_abnormal_mitochondrial_morpho1.18342623
52MP0005464_abnormal_platelet_physiology1.12626422
53MP0000639_abnormal_adrenal_gland1.10732654
54MP0005000_abnormal_immune_tolerance1.09714304
55MP0001968_abnormal_touch/_nociception1.06493025
56MP0003763_abnormal_thymus_physiology1.05415711
57MP0009785_altered_susceptibility_to1.04418525
58MP0003252_abnormal_bile_duct1.04374378
59MP0002398_abnormal_bone_marrow1.01084087
60MP0003866_abnormal_defecation1.00164133
61MP0001764_abnormal_homeostasis0.99921288
62MP0004019_abnormal_vitamin_homeostasis0.99841456
63MP0004145_abnormal_muscle_electrophysio0.99680817
64MP0001765_abnormal_ion_homeostasis0.99626528
65MP0002723_abnormal_immune_serum0.99018735
66MP0005332_abnormal_amino_acid0.98418357
67MP0001486_abnormal_startle_reflex0.98274139
68MP0010329_abnormal_lipoprotein_level0.97959137
69MP0002452_abnormal_antigen_presenting0.96884214
70MP0000015_abnormal_ear_pigmentation0.95482096
71MP0001819_abnormal_immune_cell0.94476130
72MP0001485_abnormal_pinna_reflex0.93262634
73MP0001919_abnormal_reproductive_system0.92596562
74MP0002420_abnormal_adaptive_immunity0.89774379
75MP0004742_abnormal_vestibular_system0.88266696
76MP0004947_skin_inflammation0.87151860
77MP0001800_abnormal_humoral_immune0.86817469
78MP0009697_abnormal_copulation0.85711879
79MP0005330_cardiomyopathy0.85198190
80MP0000013_abnormal_adipose_tissue0.84377315
81MP0004885_abnormal_endolymph0.84034663
82MP0000358_abnormal_cell_content/0.82671943
83MP0001119_abnormal_female_reproductive0.82600561
84MP0005410_abnormal_fertilization0.82301192
85MP0002019_abnormal_tumor_incidence0.82212034
86MP0001984_abnormal_olfaction0.80887030
87MP0008872_abnormal_physiological_respon0.77601713
88MP0002693_abnormal_pancreas_physiology0.77550194
89MP0003111_abnormal_nucleus_morphology0.77133323
90MP0005266_abnormal_metabolism0.76935238
91MP0006292_abnormal_olfactory_placode0.75909871
92MP0000685_abnormal_immune_system0.75392129
93MP0001790_abnormal_immune_system0.75071610
94MP0005387_immune_system_phenotype0.75071610
95MP0000703_abnormal_thymus_morphology0.74866417
96MP0003195_calcinosis0.74759811
97MP0008873_increased_physiological_sensi0.73414853
98MP0009053_abnormal_anal_canal0.73106947
99MP0005645_abnormal_hypothalamus_physiol0.70996934
100MP0001873_stomach_inflammation0.69687969

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)6.88108764
2Methylmalonic aciduria (HP:0012120)4.92535424
3Abnormality of the vitamin B12 metabolism (HP:0004341)4.54591190
4Abnormality of vitamin B metabolism (HP:0004340)4.44514126
5Elevated erythrocyte sedimentation rate (HP:0003565)4.11235842
6Petechiae (HP:0000967)3.86782739
7Aplastic anemia (HP:0001915)3.82546221
8Meckel diverticulum (HP:0002245)3.66885583
9Abnormality of the ileum (HP:0001549)3.49163353
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.46695034
11Increased hepatocellular lipid droplets (HP:0006565)3.39022925
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.35894395
13Hepatocellular necrosis (HP:0001404)3.32798656
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.25748429
15Lipid accumulation in hepatocytes (HP:0006561)3.25281428
16Abnormality of vitamin metabolism (HP:0100508)3.23200391
17Increased serum lactate (HP:0002151)3.22318983
18Increased CSF lactate (HP:0002490)3.18713003
19Mitochondrial inheritance (HP:0001427)3.18145015
20Hepatic necrosis (HP:0002605)3.13603742
213-Methylglutaconic aciduria (HP:0003535)3.12619982
22Renal cortical cysts (HP:0000803)3.11259173
23Abnormality of the preputium (HP:0100587)3.10717579
24Acute necrotizing encephalopathy (HP:0006965)3.06191931
25Acute encephalopathy (HP:0006846)3.02788508
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00190545
27Abnormality of alanine metabolism (HP:0010916)3.00190545
28Hyperalaninemia (HP:0003348)3.00190545
29Abnormality of the carotid arteries (HP:0005344)2.94878154
30Clubbing of toes (HP:0100760)2.90581567
31Poor head control (HP:0002421)2.79633091
32Pigmentary retinal degeneration (HP:0001146)2.77798346
33Hyperglycinuria (HP:0003108)2.75256576
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.74629365
35Hypoplasia of the fovea (HP:0007750)2.74629365
36Renal Fanconi syndrome (HP:0001994)2.71564231
37Abnormality of chromosome stability (HP:0003220)2.71368658
38Abnormal mitochondria in muscle tissue (HP:0008316)2.69617776
39Severe combined immunodeficiency (HP:0004430)2.67642153
40Dicarboxylic aciduria (HP:0003215)2.59182625
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59182625
42Abnormality of glycine metabolism (HP:0010895)2.56583316
43Abnormality of serine family amino acid metabolism (HP:0010894)2.56583316
44IgG deficiency (HP:0004315)2.56164291
45Progressive macrocephaly (HP:0004481)2.53945139
46Pancytopenia (HP:0001876)2.53732022
47Facial diplegia (HP:0001349)2.52597512
48Prolonged neonatal jaundice (HP:0006579)2.49035030
49Hemiparesis (HP:0001269)2.48447460
50Duodenal stenosis (HP:0100867)2.47270920
51Small intestinal stenosis (HP:0012848)2.47270920
52Lactic acidosis (HP:0003128)2.45371411
53Cleft eyelid (HP:0000625)2.45217794
54Abnormal number of erythroid precursors (HP:0012131)2.43756065
55Testicular atrophy (HP:0000029)2.38576181
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37659116
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37659116
58Curly hair (HP:0002212)2.31122092
59B lymphocytopenia (HP:0010976)2.25874939
60Combined immunodeficiency (HP:0005387)2.25210537
61Leukopenia (HP:0001882)2.22755576
62Abnormality of the fovea (HP:0000493)2.22479823
63Progressive microcephaly (HP:0000253)2.20916688
64Abnormality of the duodenum (HP:0002246)2.20328377
65Thyroiditis (HP:0100646)2.17049356
66Septate vagina (HP:0001153)2.16512214
67Hyperglycinemia (HP:0002154)2.12403729
68Increased intramyocellular lipid droplets (HP:0012240)2.11927869
69Myelodysplasia (HP:0002863)2.11915139
70Cerebral edema (HP:0002181)2.09330887
71Pancreatic cysts (HP:0001737)2.08388528
72Abnormality of the renal cortex (HP:0011035)2.05841007
73Oral leukoplakia (HP:0002745)2.02681323
74Abnormality of serum amino acid levels (HP:0003112)2.02523660
75Prolonged bleeding time (HP:0003010)1.99469104
76Micronodular cirrhosis (HP:0001413)1.99254256
77Abnormality of B cell number (HP:0010975)1.93031244
78Generalized aminoaciduria (HP:0002909)1.89126744
79Acute hepatic failure (HP:0006554)1.88486041
80Cerebral palsy (HP:0100021)1.85610727
81Elfin facies (HP:0004428)1.84636866
82Abnormality of cells of the erythroid lineage (HP:0012130)1.83959191
83Exertional dyspnea (HP:0002875)1.83102792
84Neutropenia (HP:0001875)1.82469766
85Medial flaring of the eyebrow (HP:0010747)1.82329439
86Pendular nystagmus (HP:0012043)1.81358571
87Hydroxyprolinuria (HP:0003080)1.79871153
88Abnormality of proline metabolism (HP:0010907)1.79871153
89Purpura (HP:0000979)1.79793254
90Abnormality of the renal collecting system (HP:0004742)1.79367352
91Porencephaly (HP:0002132)1.79175561
92Increased muscle lipid content (HP:0009058)1.78978202
93High anterior hairline (HP:0009890)1.78022080
94Progressive inability to walk (HP:0002505)1.77863713
95Chromsome breakage (HP:0040012)1.77381964
96Respiratory failure (HP:0002878)1.76562302
97Abnormality of urine glucose concentration (HP:0011016)1.75773144
98Glycosuria (HP:0003076)1.75773144
99Duplicated collecting system (HP:0000081)1.73618565
100Congenital stationary night blindness (HP:0007642)1.73120810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.76046234
2MST44.44984482
3TXK3.20168886
4BMPR1B2.67378842
5NUAK12.64426762
6MAP4K12.55323485
7TESK22.52453303
8KDR2.45895882
9TAF12.37845931
10MAP3K122.26896451
11STK102.04346791
12TLK11.94616843
13BUB11.92277072
14EIF2AK11.90719209
15VRK11.83894303
16EIF2AK31.81794331
17EIF2AK21.80471901
18SRPK11.73231257
19PBK1.73145506
20GRK11.71540682
21GRK71.67237329
22TIE11.62373921
23NEK11.50117345
24RPS6KA41.45474851
25GRK51.36567953
26TGFBR21.34763969
27DAPK11.32052385
28TGFBR11.27130488
29CSNK1G21.26259338
30WNK31.22302952
31PDK21.18096773
32MKNK21.16018681
33ADRBK21.11222300
34NME11.10061339
35MKNK11.08612673
36CSNK1G31.07928626
37DYRK21.03586133
38ATR1.02308324
39IRAK11.02216457
40TNK21.01646514
41KIT0.93454969
42TRIM280.90893505
43IKBKB0.89543052
44DAPK20.87229832
45CSNK1G10.85147318
46TNIK0.84337838
47MAP3K50.82253688
48PLK30.81488478
49CDC70.81088535
50PAK30.80837062
51TEC0.78672535
52CSNK1A1L0.76341299
53CCNB10.71818445
54STK160.70585572
55PIM20.70543214
56PLK40.69685923
57CDK80.69218854
58TSSK60.69003936
59STK40.68028135
60TESK10.67424995
61STK38L0.67007884
62INSRR0.61235462
63MAPK130.60669152
64FRK0.59515218
65WEE10.58197076
66ACVR1B0.57808922
67AKT30.57685240
68DAPK30.57617996
69MYLK0.56775398
70AURKB0.56079541
71JAK10.55369569
72MELK0.53394601
73MOS0.53092093
74CDK60.52930975
75PRKCI0.52526189
76PRKCQ0.51131490
77CDK90.50365366
78ITK0.49834529
79CHUK0.49455664
80CDK70.48442835
81BCKDK0.48335838
82ILK0.47105205
83MAPKAPK50.46116361
84SYK0.45798311
85RPS6KA50.45492416
86MAP3K40.44479979
87PRKCH0.42952022
88PLK20.42932261
89SCYL20.41990361
90CSNK2A10.41445378
91ZAK0.40837344
92PRKCE0.34583399
93ATM0.33483195
94NME20.33468077
95STK390.33381653
96ADRBK10.32123472
97CSNK1E0.32008664
98MAP2K70.31452093
99NEK20.31086656
100MAPKAPK30.30180600

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.68692287
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.90370632
3Protein export_Homo sapiens_hsa030603.84438885
4Oxidative phosphorylation_Homo sapiens_hsa001903.08512095
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05608387
6Propanoate metabolism_Homo sapiens_hsa006402.90754261
7RNA polymerase_Homo sapiens_hsa030202.48994118
8Non-homologous end-joining_Homo sapiens_hsa034502.48094276
9Parkinsons disease_Homo sapiens_hsa050122.41503827
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33625547
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32269710
12Basal transcription factors_Homo sapiens_hsa030222.31386584
13Fanconi anemia pathway_Homo sapiens_hsa034602.26273090
14RNA degradation_Homo sapiens_hsa030182.08236338
15Spliceosome_Homo sapiens_hsa030402.03807990
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98657867
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82276489
18Antigen processing and presentation_Homo sapiens_hsa046121.79600168
19Huntingtons disease_Homo sapiens_hsa050161.77811713
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76446153
21Primary immunodeficiency_Homo sapiens_hsa053401.75122566
22Alzheimers disease_Homo sapiens_hsa050101.60618283
23Mismatch repair_Homo sapiens_hsa034301.55663511
24Homologous recombination_Homo sapiens_hsa034401.50056601
25One carbon pool by folate_Homo sapiens_hsa006701.45215264
26Pyrimidine metabolism_Homo sapiens_hsa002401.43710885
27RNA transport_Homo sapiens_hsa030131.37696604
28Nucleotide excision repair_Homo sapiens_hsa034201.36182641
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23218940
30Graft-versus-host disease_Homo sapiens_hsa053321.21749993
31Ribosome_Homo sapiens_hsa030101.18837022
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13091593
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.04285774
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04082314
35DNA replication_Homo sapiens_hsa030301.03993196
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02913596
37Phototransduction_Homo sapiens_hsa047441.02562818
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02374068
39Pyruvate metabolism_Homo sapiens_hsa006201.01749915
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.98791410
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94331177
42Asthma_Homo sapiens_hsa053100.93907853
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.92508087
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91804859
45Purine metabolism_Homo sapiens_hsa002300.88861129
46Sulfur metabolism_Homo sapiens_hsa009200.87545641
47Autoimmune thyroid disease_Homo sapiens_hsa053200.86247607
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.82518979
49Legionellosis_Homo sapiens_hsa051340.81945826
50Glutathione metabolism_Homo sapiens_hsa004800.80226136
51Peroxisome_Homo sapiens_hsa041460.79801359
52Allograft rejection_Homo sapiens_hsa053300.79026532
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77306805
54Regulation of autophagy_Homo sapiens_hsa041400.74604846
55beta-Alanine metabolism_Homo sapiens_hsa004100.73171031
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70713202
57Caffeine metabolism_Homo sapiens_hsa002320.68774613
58Butanoate metabolism_Homo sapiens_hsa006500.68147277
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.66702230
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65932275
61Carbon metabolism_Homo sapiens_hsa012000.63999317
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63222306
63Tryptophan metabolism_Homo sapiens_hsa003800.63080262
64Hematopoietic cell lineage_Homo sapiens_hsa046400.60116263
65Metabolic pathways_Homo sapiens_hsa011000.60017602
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59643844
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57986538
68Olfactory transduction_Homo sapiens_hsa047400.57571073
69Epstein-Barr virus infection_Homo sapiens_hsa051690.56070132
70Fatty acid degradation_Homo sapiens_hsa000710.51648789
71Base excision repair_Homo sapiens_hsa034100.51533770
72Collecting duct acid secretion_Homo sapiens_hsa049660.50288941
73Vitamin digestion and absorption_Homo sapiens_hsa049770.49433693
74Dorso-ventral axis formation_Homo sapiens_hsa043200.46603094
75Type I diabetes mellitus_Homo sapiens_hsa049400.46136930
76Nicotine addiction_Homo sapiens_hsa050330.45983455
77mRNA surveillance pathway_Homo sapiens_hsa030150.45729297
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41210795
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40598055
80Chemical carcinogenesis_Homo sapiens_hsa052040.39711363
81Sulfur relay system_Homo sapiens_hsa041220.39237155
82Selenocompound metabolism_Homo sapiens_hsa004500.37740784
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35772559
84Linoleic acid metabolism_Homo sapiens_hsa005910.33005910
85Vitamin B6 metabolism_Homo sapiens_hsa007500.32915817
86Herpes simplex infection_Homo sapiens_hsa051680.32755553
87Nitrogen metabolism_Homo sapiens_hsa009100.32727888
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.30089352
89Cardiac muscle contraction_Homo sapiens_hsa042600.29438554
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27743331
91Fatty acid elongation_Homo sapiens_hsa000620.27033877
92Mineral absorption_Homo sapiens_hsa049780.26816122
93Rheumatoid arthritis_Homo sapiens_hsa053230.26243044
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26010458
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25462967
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24916741
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24577585
98Retinol metabolism_Homo sapiens_hsa008300.20289643
99Shigellosis_Homo sapiens_hsa051310.19530073
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.19327732

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