TPM3P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.73652942
2regulation of germinal center formation (GO:0002634)5.55060429
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.37975211
4axoneme assembly (GO:0035082)5.10957992
5cilium movement (GO:0003341)4.83791448
6peptidyl-histidine modification (GO:0018202)4.80859809
7epithelial cilium movement (GO:0003351)4.71544852
8retinal cone cell development (GO:0046549)4.49370864
9phosphatidylglycerol biosynthetic process (GO:0006655)4.16788644
10hemidesmosome assembly (GO:0031581)4.14648465
11retinal rod cell development (GO:0046548)4.10862584
12regulation of DNA endoreduplication (GO:0032875)3.95560510
13DNA deamination (GO:0045006)3.93022198
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79947609
15axonemal dynein complex assembly (GO:0070286)3.78889164
16estrogen biosynthetic process (GO:0006703)3.62985134
17regulation of B cell receptor signaling pathway (GO:0050855)3.62556682
18mature B cell differentiation (GO:0002335)3.60772762
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60062630
20actin nucleation (GO:0045010)3.50439359
21transcription elongation from RNA polymerase I promoter (GO:0006362)3.49752467
22response to inactivity (GO:0014854)3.45924059
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.44664307
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42224182
25rRNA catabolic process (GO:0016075)3.41630735
26negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.35229525
27negative regulation of thymocyte apoptotic process (GO:0070244)3.28719914
28positive regulation of defense response to virus by host (GO:0002230)3.25704127
29positive regulation of protein sumoylation (GO:0033235)3.24604691
30regulation of defense response to virus by host (GO:0050691)3.24209912
31cell differentiation involved in metanephros development (GO:0072202)3.21599746
32motile cilium assembly (GO:0044458)3.17406394
33negative regulation of B cell proliferation (GO:0030889)3.16461345
34mucosal-associated lymphoid tissue development (GO:0048537)3.11732316
35Peyers patch development (GO:0048541)3.11732316
36termination of RNA polymerase I transcription (GO:0006363)3.11308223
37regulation of cilium movement (GO:0003352)3.10724696
38cardiolipin metabolic process (GO:0032048)3.09014698
39S-adenosylmethionine metabolic process (GO:0046500)3.04007434
40cytidine deamination (GO:0009972)3.03844793
41cytidine metabolic process (GO:0046087)3.03844793
42cytidine catabolic process (GO:0006216)3.03844793
43ubiquinone biosynthetic process (GO:0006744)2.99245070
44regulation of B cell proliferation (GO:0030888)2.99237259
45ribosome assembly (GO:0042255)2.98769831
46positive regulation of B cell proliferation (GO:0030890)2.97216714
47mannosylation (GO:0097502)2.94217284
48mesenchymal cell differentiation involved in kidney development (GO:0072161)2.91460333
49mesenchymal cell differentiation involved in renal system development (GO:2001012)2.91460333
50organelle membrane fusion (GO:0090174)2.90706511
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89010003
52intraciliary transport (GO:0042073)2.87157232
53DNA double-strand break processing (GO:0000729)2.86821556
54protein K11-linked deubiquitination (GO:0035871)2.86687369
55transcription initiation from RNA polymerase I promoter (GO:0006361)2.86012380
56B cell activation (GO:0042113)2.81447542
57positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.81225346
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80822755
59spliceosomal complex assembly (GO:0000245)2.72732731
60negative regulation of sodium ion transport (GO:0010766)2.71970078
61preassembly of GPI anchor in ER membrane (GO:0016254)2.71554024
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71369137
63negative regulation of DNA-templated transcription, elongation (GO:0032785)2.70813453
64mature B cell differentiation involved in immune response (GO:0002313)2.69460286
65regulation of memory T cell differentiation (GO:0043380)2.68915423
66purine deoxyribonucleotide catabolic process (GO:0009155)2.68768747
67mast cell activation (GO:0045576)2.68309170
68response to xenobiotic stimulus (GO:0009410)2.67189599
69positive regulation of B cell differentiation (GO:0045579)2.64030128
70positive regulation of meiotic cell cycle (GO:0051446)2.64014232
71magnesium ion transport (GO:0015693)2.63619037
72B cell activation involved in immune response (GO:0002312)2.61846503
73negative regulation of alpha-beta T cell activation (GO:0046636)2.61117690
74regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.60338629
75indolalkylamine metabolic process (GO:0006586)2.60314611
76ubiquinone metabolic process (GO:0006743)2.59695986
77regulation of action potential (GO:0098900)2.59330128
78recombinational repair (GO:0000725)2.59118863
79regulation of interleukin-6 biosynthetic process (GO:0045408)2.58464192
80double-strand break repair via homologous recombination (GO:0000724)2.55093622
81ribonucleoprotein complex disassembly (GO:0032988)2.54794123
82purine nucleotide salvage (GO:0032261)2.53395938
83pyrimidine ribonucleoside catabolic process (GO:0046133)2.53205325
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53180097
85autophagic vacuole fusion (GO:0000046)2.52595504
86B cell differentiation (GO:0030183)2.52369600
87inner mitochondrial membrane organization (GO:0007007)2.51221156
88tryptophan metabolic process (GO:0006568)2.49158328
89left/right axis specification (GO:0070986)2.48866150
90retina homeostasis (GO:0001895)2.48044362
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.47109717
92histone mRNA catabolic process (GO:0071044)2.47014739
93mitochondrial DNA replication (GO:0006264)2.46924135
94spliceosomal snRNP assembly (GO:0000387)2.46844659
95regulation of alpha-beta T cell proliferation (GO:0046640)2.46421960
96transcription from RNA polymerase I promoter (GO:0006360)2.45843479
97positive regulation of heat generation (GO:0031652)2.45781786
98B cell homeostasis (GO:0001782)2.44850750
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44064918
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42209651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.17901390
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02225687
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71831858
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01428877
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80353881
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78001686
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.66506970
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.64265125
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.59785001
10IGF1R_20145208_ChIP-Seq_DFB_Human2.37802193
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37391994
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20982440
13TAF15_26573619_Chip-Seq_HEK293_Human2.10537341
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06776697
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04072427
16VDR_23849224_ChIP-Seq_CD4+_Human1.91482451
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.90884764
18CBP_20019798_ChIP-Seq_JUKART_Human1.90884764
19VDR_22108803_ChIP-Seq_LS180_Human1.89606830
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88084444
21GATA1_22025678_ChIP-Seq_K562_Human1.84492815
22EWS_26573619_Chip-Seq_HEK293_Human1.78429436
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.78251967
24ELK1_19687146_ChIP-ChIP_HELA_Human1.75856327
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.67647689
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61444892
27ER_23166858_ChIP-Seq_MCF-7_Human1.60253027
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58057135
29CIITA_25753668_ChIP-Seq_RAJI_Human1.57878882
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.57354733
31BCAT_22108803_ChIP-Seq_LS180_Human1.46646367
32GATA3_26560356_Chip-Seq_TH2_Human1.45353646
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45194248
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44696406
35TCF4_22108803_ChIP-Seq_LS180_Human1.43332623
36ZNF274_21170338_ChIP-Seq_K562_Hela1.42767446
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.42253930
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41942467
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41359367
40AR_21572438_ChIP-Seq_LNCaP_Human1.39736995
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.39627598
42TP53_16413492_ChIP-PET_HCT116_Human1.39194171
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38670694
44FOXP3_21729870_ChIP-Seq_TREG_Human1.37052104
45TP53_22573176_ChIP-Seq_HFKS_Human1.35402967
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.32684087
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32325375
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29712078
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28881074
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.28625946
51FOXH1_21741376_ChIP-Seq_EPCs_Human1.28277495
52SMAD4_21799915_ChIP-Seq_A2780_Human1.27910860
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23664977
54EZH2_22144423_ChIP-Seq_EOC_Human1.21414772
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19889993
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19590941
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18418190
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17711819
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17541495
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17337085
61P300_19829295_ChIP-Seq_ESCs_Human1.16408203
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15480519
63NCOR_22424771_ChIP-Seq_293T_Human1.15064602
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14677181
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13574416
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12898442
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12712758
68SOX2_19829295_ChIP-Seq_ESCs_Human1.12712758
69STAT3_23295773_ChIP-Seq_U87_Human1.09582221
70GBX2_23144817_ChIP-Seq_PC3_Human1.09084621
71TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08806019
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06176451
73NFYA_21822215_ChIP-Seq_K562_Human1.04584067
74RXR_22108803_ChIP-Seq_LS180_Human1.03432160
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03360329
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03360329
77SMRT_27268052_Chip-Seq_Bcells_Human1.02977615
78ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02495749
79FUS_26573619_Chip-Seq_HEK293_Human1.01065507
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.00118908
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.99442095
82MYC_18940864_ChIP-ChIP_HL60_Human0.99316122
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98448458
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98408694
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.98408694
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98359415
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97590724
88TBL1_22424771_ChIP-Seq_293T_Human0.97530626
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97503347
90TCF4_23295773_ChIP-Seq_U87_Human0.97065183
91P53_22387025_ChIP-Seq_ESCs_Mouse0.96417243
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95189228
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94513944
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93948528
95AHR_22903824_ChIP-Seq_MCF-7_Human0.93530427
96NFYB_21822215_ChIP-Seq_K562_Human0.92683664
97AR_20517297_ChIP-Seq_VCAP_Human0.92303484
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92205284
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92204126
100MYB_26560356_Chip-Seq_TH2_Human0.91574487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.72300606
2MP0006292_abnormal_olfactory_placode3.69985637
3MP0002166_altered_tumor_susceptibility3.62424327
4MP0008057_abnormal_DNA_replication3.14681880
5MP0004147_increased_porphyrin_level3.13001375
6MP0001835_abnormal_antigen_presentation3.02692706
7MP0005671_abnormal_response_to2.98664004
8MP0002006_tumorigenesis2.86367033
9MP0000569_abnormal_digit_pigmentation2.82863130
10MP0008877_abnormal_DNA_methylation2.40298211
11MP0009697_abnormal_copulation2.31795676
12MP0002332_abnormal_exercise_endurance2.12370450
13MP0003011_delayed_dark_adaptation2.11487003
14MP0002876_abnormal_thyroid_physiology2.06882421
15MP0003787_abnormal_imprinting1.99461686
16MP0001800_abnormal_humoral_immune1.97068166
17MP0003878_abnormal_ear_physiology1.85083314
18MP0005377_hearing/vestibular/ear_phenot1.85083314
19MP0000685_abnormal_immune_system1.81785706
20MP0010094_abnormal_chromosome_stability1.80580409
21MP0003045_fibrosis1.80052920
22MP0004142_abnormal_muscle_tone1.79325387
23MP0000383_abnormal_hair_follicle1.74704842
24MP0000013_abnormal_adipose_tissue1.72456761
25MP0002909_abnormal_adrenal_gland1.68947439
26MP0004145_abnormal_muscle_electrophysio1.66967867
27MP0003763_abnormal_thymus_physiology1.54805731
28MP0008058_abnormal_DNA_repair1.50472153
29MP0009764_decreased_sensitivity_to1.48001329
30MP0005253_abnormal_eye_physiology1.47638843
31MP0008789_abnormal_olfactory_epithelium1.44972203
32MP0002138_abnormal_hepatobiliary_system1.42995026
33MP0003252_abnormal_bile_duct1.41327263
34MP0005310_abnormal_salivary_gland1.38721806
35MP0009785_altered_susceptibility_to1.37725900
36MP0003183_abnormal_peptide_metabolism1.37049568
37MP0005645_abnormal_hypothalamus_physiol1.36162377
38MP0001790_abnormal_immune_system1.34655879
39MP0005387_immune_system_phenotype1.34655879
40MP0002452_abnormal_antigen_presenting1.32486087
41MP0005075_abnormal_melanosome_morpholog1.31829180
42MP0005266_abnormal_metabolism1.24958221
43MP0003786_premature_aging1.24430587
44MP0002723_abnormal_immune_serum1.22515240
45MP0005000_abnormal_immune_tolerance1.20106541
46MP0000427_abnormal_hair_cycle1.20103240
47MP0005451_abnormal_body_composition1.19761439
48MP0008872_abnormal_physiological_respon1.19067303
49MP0006072_abnormal_retinal_apoptosis1.18832027
50MP0008875_abnormal_xenobiotic_pharmacok1.15145458
51MP0002398_abnormal_bone_marrow1.14735702
52MP0002405_respiratory_system_inflammati1.12807233
53MP0002420_abnormal_adaptive_immunity1.12450624
54MP0002168_other_aberrant_phenotype1.10481218
55MP0001819_abnormal_immune_cell1.09634236
56MP0004043_abnormal_pH_regulation1.08505270
57MP0008007_abnormal_cellular_replicative1.07728991
58MP0000751_myopathy1.06131328
59MP0009046_muscle_twitch1.03693087
60MP0005167_abnormal_blood-brain_barrier1.03318002
61MP0000372_irregular_coat_pigmentation1.02966579
62MP0000716_abnormal_immune_system0.99929032
63MP0003121_genomic_imprinting0.99129714
64MP0003646_muscle_fatigue0.97971329
65MP0006035_abnormal_mitochondrial_morpho0.90805797
66MP0000689_abnormal_spleen_morphology0.90181296
67MP0000749_muscle_degeneration0.89193308
68MP0005084_abnormal_gallbladder_morpholo0.88472291
69MP0001986_abnormal_taste_sensitivity0.88129877
70MP0001666_abnormal_nutrient_absorption0.86682734
71MP0005379_endocrine/exocrine_gland_phen0.86389485
72MP0002148_abnormal_hypersensitivity_rea0.85448152
73MP0004264_abnormal_extraembryonic_tissu0.84831761
74MP0002653_abnormal_ependyma_morphology0.84797759
75MP0003866_abnormal_defecation0.83905378
76MP0003806_abnormal_nucleotide_metabolis0.83259220
77MP0001853_heart_inflammation0.82832350
78MP0008995_early_reproductive_senescence0.81951265
79MP0001765_abnormal_ion_homeostasis0.81433083
80MP0002095_abnormal_skin_pigmentation0.81004362
81MP0000703_abnormal_thymus_morphology0.80226839
82MP0001177_atelectasis0.77802802
83MP0005551_abnormal_eye_electrophysiolog0.77560981
84MP0001501_abnormal_sleep_pattern0.77536108
85MP0002163_abnormal_gland_morphology0.77280241
86MP0002269_muscular_atrophy0.76784099
87MP0005394_taste/olfaction_phenotype0.76369933
88MP0005499_abnormal_olfactory_system0.76369933
89MP0000613_abnormal_salivary_gland0.76325005
90MP0004133_heterotaxia0.76304846
91MP0001873_stomach_inflammation0.76078291
92MP0006276_abnormal_autonomic_nervous0.75629789
93MP0002429_abnormal_blood_cell0.75160261
94MP0002139_abnormal_hepatobiliary_system0.74909309
95MP0010678_abnormal_skin_adnexa0.71882476
96MP0002796_impaired_skin_barrier0.71393866
97MP0003195_calcinosis0.70624876
98MP0000631_abnormal_neuroendocrine_gland0.69236539
99MP0002938_white_spotting0.67238545
100MP0003077_abnormal_cell_cycle0.66795893

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)5.70828230
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.63394761
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.56475205
4Absent/shortened dynein arms (HP:0200106)4.56475205
5Chronic hepatic failure (HP:0100626)4.34279316
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28596458
7Urethral obstruction (HP:0000796)4.24011326
8Alopecia of scalp (HP:0002293)4.23965156
9Thick nail (HP:0001805)4.04997943
10Abnormal rod and cone electroretinograms (HP:0008323)3.52186889
11Increased connective tissue (HP:0009025)3.34345519
12Recurrent cutaneous fungal infections (HP:0011370)3.24638174
13Chronic mucocutaneous candidiasis (HP:0002728)3.24638174
14Fatigable weakness (HP:0003473)3.23457255
15Abnormality of the neuromuscular junction (HP:0003398)3.23457255
16Oligomenorrhea (HP:0000876)3.23135529
17Chronic bronchitis (HP:0004469)3.21564995
18Microretrognathia (HP:0000308)3.18444174
19Abnormal respiratory motile cilium morphology (HP:0005938)3.14588747
20Abnormal respiratory epithelium morphology (HP:0012253)3.14588747
21Thyroiditis (HP:0100646)3.10903247
22Abnormal respiratory motile cilium physiology (HP:0012261)3.10753145
23Keratitis (HP:0000491)3.00437891
24Severe combined immunodeficiency (HP:0004430)2.98513457
25Volvulus (HP:0002580)2.92181149
26Abnormal ciliary motility (HP:0012262)2.86954962
27T lymphocytopenia (HP:0005403)2.86709067
28Bronchitis (HP:0012387)2.85655432
29Rhinitis (HP:0012384)2.85304957
30B lymphocytopenia (HP:0010976)2.82504211
31IgG deficiency (HP:0004315)2.77191961
32Molar tooth sign on MRI (HP:0002419)2.76785817
33Abnormality of midbrain morphology (HP:0002418)2.76785817
34Recurrent bronchitis (HP:0002837)2.60967607
35Bony spicule pigmentary retinopathy (HP:0007737)2.58221008
36Partial agenesis of the corpus callosum (HP:0001338)2.56502929
37Abnormality of T cell number (HP:0011839)2.55205218
38Menstrual irregularities (HP:0000858)2.53548834
39Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.51162180
40Short 1st metacarpal (HP:0010034)2.51162180
41Abnormality of B cell number (HP:0010975)2.49690661
42Sex reversal (HP:0012245)2.45835992
43Abnormal sex determination (HP:0012244)2.45835992
44Short chin (HP:0000331)2.39297459
45Chronic sinusitis (HP:0011109)2.35454131
46Attenuation of retinal blood vessels (HP:0007843)2.30230820
47Agammaglobulinemia (HP:0004432)2.27298080
48Abolished electroretinogram (ERG) (HP:0000550)2.26228660
49Tubulointerstitial nephritis (HP:0001970)2.19004574
50Supernumerary spleens (HP:0009799)2.17108543
51Clumsiness (HP:0002312)2.16795274
52Bronchiectasis (HP:0002110)2.16204330
53Abnormality of the 1st metacarpal (HP:0010009)2.14642446
54Supernumerary nipples (HP:0002558)2.13843967
55Keratoconjunctivitis (HP:0001096)2.13770736
56Combined immunodeficiency (HP:0005387)2.13078360
57Panhypogammaglobulinemia (HP:0003139)2.11980900
58Difficulty climbing stairs (HP:0003551)2.11138011
59Milia (HP:0001056)2.08084133
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.07439861
61Encephalitis (HP:0002383)2.06609052
62Prominent nose (HP:0000448)2.06214995
63Abnormality of eosinophils (HP:0001879)2.04861094
64Fatigue (HP:0012378)2.04683360
65Abnormal tarsal ossification (HP:0008369)2.03856573
66Recurrent fungal infections (HP:0002841)2.02932536
67Retrobulbar optic neuritis (HP:0100654)2.00226434
68Optic neuritis (HP:0100653)2.00226434
69Recurrent viral infections (HP:0004429)1.99202770
70Constricted visual fields (HP:0001133)1.97490756
71Neoplasm of the tracheobronchial system (HP:0100552)1.95396220
72Pancreatic cysts (HP:0001737)1.93906406
73Asplenia (HP:0001746)1.93399061
74Facial diplegia (HP:0001349)1.92976873
75Recurrent sinusitis (HP:0011108)1.90276495
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.90266409
77Keratoconjunctivitis sicca (HP:0001097)1.89268779
78Autoimmune thrombocytopenia (HP:0001973)1.81612502
79Hypokalemic alkalosis (HP:0001949)1.75886248
80Hypoplastic scapulae (HP:0000882)1.73005099
81Aplasia/Hypoplasia of the scapulae (HP:0006713)1.73005099
82Autoimmune hemolytic anemia (HP:0001890)1.72092285
83Short metatarsal (HP:0010743)1.72050826
84Median cleft lip (HP:0000161)1.71912613
85Abnormality of T cells (HP:0002843)1.71570586
86Truncal obesity (HP:0001956)1.71396204
87Optic nerve coloboma (HP:0000588)1.69620111
88Increased hepatocellular lipid droplets (HP:0006565)1.67168641
89Recurrent otitis media (HP:0000403)1.67129814
90Infertility (HP:0000789)1.67088148
91Pancreatic fibrosis (HP:0100732)1.66007620
92Abnormality of the fingertips (HP:0001211)1.65499041
93Type II lissencephaly (HP:0007260)1.64628132
94Broad face (HP:0000283)1.63238062
95Exertional dyspnea (HP:0002875)1.62933046
96Elevated erythrocyte sedimentation rate (HP:0003565)1.62839865
97Recurrent pneumonia (HP:0006532)1.61211608
98Orchitis (HP:0100796)1.60846516
99Aplasia/hypoplasia of the uterus (HP:0008684)1.59863618
100Unilateral renal agenesis (HP:0000122)1.59057055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.61576191
2EIF2AK14.07100224
3CDK193.57919821
4MST43.54687330
5NEK13.20915642
6WNK42.97102180
7AKT32.81615185
8IRAK12.56176478
9ZAK2.45201369
10TRPM72.35357470
11GRK12.28587082
12MUSK1.97919460
13BMPR21.90852289
14TXK1.86147972
15TAOK31.81029314
16OXSR11.72664997
17FRK1.70706453
18ADRBK21.65127057
19IRAK21.63297340
20TYK21.60876783
21CSF1R1.53466772
22RIPK41.48659706
23IKBKE1.40347631
24VRK21.37289385
25PHKG21.35267757
26PHKG11.35267757
27CDK121.26404749
28MAP3K71.24874027
29KIT1.19571864
30BMPR1B1.13363801
31AURKB1.13079570
32NUAK11.09471583
33IKBKB1.09406623
34MARK21.09364552
35SGK21.04195447
36CAMK41.02180902
37BCR0.98698388
38TLK10.91622128
39MAPK110.91438802
40CAMK10.90650196
41EIF2AK20.90035513
42RPS6KA60.89882946
43RPS6KL10.86048302
44RPS6KC10.86048302
45STK110.85194772
46STK160.83796860
47TNIK0.82909834
48STK390.82545685
49MAP4K10.80754581
50CHEK20.79757669
51MAP3K140.78149390
52TSSK60.73940308
53JAK30.73278470
54CDK90.72148016
55SIK20.71348491
56SYK0.68496767
57MKNK10.67524779
58PLK10.66095797
59PAK30.63149557
60ATR0.60507586
61CHUK0.58758928
62MAPK70.58589091
63MAPKAPK50.58444885
64IRAK40.58077955
65ATM0.57429573
66MKNK20.55263199
67WNK10.54590207
68NME10.51635868
69PLK40.50151951
70SGK30.44451676
71WNK30.43513180
72STK40.42997239
73SGK10.42322351
74TEC0.41815993
75LRRK20.41166521
76TTK0.40757023
77MAP4K20.40677579
78NEK60.40623811
79PRKACB0.40524050
80RPS6KB10.40419546
81MYLK0.39710449
82PLK30.39145571
83CDK40.38395854
84EGFR0.38083910
85TBK10.37905404
86BUB10.37233801
87SGK2230.37171363
88SGK4940.37171363
89PRKCE0.35252070
90STK30.34339933
91CDC70.33632515
92HCK0.33334194
93STK100.33311642
94FES0.30706687
95IGF1R0.29687460
96JAK10.29366757
97TRIM280.28963052
98CSNK2A20.28653412
99CHEK10.28248707
100INSRR0.26665290

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.97702285
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.46504091
3Allograft rejection_Homo sapiens_hsa053303.02735114
4Non-homologous end-joining_Homo sapiens_hsa034503.01276275
5Primary immunodeficiency_Homo sapiens_hsa053402.99111499
6Autoimmune thyroid disease_Homo sapiens_hsa053202.96034286
7Type I diabetes mellitus_Homo sapiens_hsa049402.94858392
8Graft-versus-host disease_Homo sapiens_hsa053322.93559717
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65122200
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48873747
11Proteasome_Homo sapiens_hsa030502.39418420
12Antigen processing and presentation_Homo sapiens_hsa046122.38433574
13RNA degradation_Homo sapiens_hsa030182.24637406
14Basal transcription factors_Homo sapiens_hsa030222.08305275
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05265545
16Spliceosome_Homo sapiens_hsa030401.90869820
17RNA polymerase_Homo sapiens_hsa030201.86200261
18Homologous recombination_Homo sapiens_hsa034401.75984641
19Protein export_Homo sapiens_hsa030601.66890245
20Linoleic acid metabolism_Homo sapiens_hsa005911.63757333
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.56649606
22One carbon pool by folate_Homo sapiens_hsa006701.49857581
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49125124
24Rheumatoid arthritis_Homo sapiens_hsa053231.48053525
25Leishmaniasis_Homo sapiens_hsa051401.44032860
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43694806
27Staphylococcus aureus infection_Homo sapiens_hsa051501.39217670
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36629398
29Nitrogen metabolism_Homo sapiens_hsa009101.30558392
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29126368
31Viral myocarditis_Homo sapiens_hsa054161.26987211
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22265636
33Ribosome_Homo sapiens_hsa030101.12217214
34Hematopoietic cell lineage_Homo sapiens_hsa046401.10644694
35Fanconi anemia pathway_Homo sapiens_hsa034601.06257590
36Olfactory transduction_Homo sapiens_hsa047401.02864974
37Herpes simplex infection_Homo sapiens_hsa051681.00720605
38RNA transport_Homo sapiens_hsa030130.98739867
39Circadian rhythm_Homo sapiens_hsa047100.98288502
40Caffeine metabolism_Homo sapiens_hsa002320.97990700
41Systemic lupus erythematosus_Homo sapiens_hsa053220.95251769
42Nucleotide excision repair_Homo sapiens_hsa034200.94691891
43Phototransduction_Homo sapiens_hsa047440.93615916
44Ether lipid metabolism_Homo sapiens_hsa005650.85728193
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.85092751
46Oxidative phosphorylation_Homo sapiens_hsa001900.84992615
47Huntingtons disease_Homo sapiens_hsa050160.82624691
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79592768
49Measles_Homo sapiens_hsa051620.79028825
50Chemical carcinogenesis_Homo sapiens_hsa052040.77420344
51Retinol metabolism_Homo sapiens_hsa008300.77206788
52Influenza A_Homo sapiens_hsa051640.77031261
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.76696384
54Butanoate metabolism_Homo sapiens_hsa006500.74451993
55Tuberculosis_Homo sapiens_hsa051520.74076045
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74051690
57Epstein-Barr virus infection_Homo sapiens_hsa051690.73834179
58Pyrimidine metabolism_Homo sapiens_hsa002400.73485940
59Fatty acid biosynthesis_Homo sapiens_hsa000610.73297296
60Purine metabolism_Homo sapiens_hsa002300.71456859
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68297276
62Parkinsons disease_Homo sapiens_hsa050120.68189087
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68127975
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.65130961
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65104782
66Selenocompound metabolism_Homo sapiens_hsa004500.63846440
67Propanoate metabolism_Homo sapiens_hsa006400.63000785
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61594082
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60260628
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58014840
71p53 signaling pathway_Homo sapiens_hsa041150.56452417
72Toxoplasmosis_Homo sapiens_hsa051450.55652379
73Tryptophan metabolism_Homo sapiens_hsa003800.55312486
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54152470
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51536111
76B cell receptor signaling pathway_Homo sapiens_hsa046620.48996785
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48524760
78Arachidonic acid metabolism_Homo sapiens_hsa005900.48188085
79Base excision repair_Homo sapiens_hsa034100.47003209
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44173326
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44041040
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43700966
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42841279
84Lysine degradation_Homo sapiens_hsa003100.42656264
85HTLV-I infection_Homo sapiens_hsa051660.40819236
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40372802
87Taste transduction_Homo sapiens_hsa047420.39096623
88Mismatch repair_Homo sapiens_hsa034300.34323564
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34144858
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30836411
91Fat digestion and absorption_Homo sapiens_hsa049750.30225296
92Legionellosis_Homo sapiens_hsa051340.29161498
93Hedgehog signaling pathway_Homo sapiens_hsa043400.27107180
94Metabolic pathways_Homo sapiens_hsa011000.26494845
95beta-Alanine metabolism_Homo sapiens_hsa004100.26030322
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25910606
97T cell receptor signaling pathway_Homo sapiens_hsa046600.22712799
98Vitamin digestion and absorption_Homo sapiens_hsa049770.22496412
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.21827321
100mRNA surveillance pathway_Homo sapiens_hsa030150.21077292

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