TPM3P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.35754492
2cytidine deamination (GO:0009972)5.75536946
3cytidine metabolic process (GO:0046087)5.75536946
4cytidine catabolic process (GO:0006216)5.75536946
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.62101666
6regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.32404375
7pyrimidine ribonucleoside catabolic process (GO:0046133)4.98683952
8negative regulation of T-helper cell differentiation (GO:0045623)4.48718017
9negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.48718017
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.40461850
11negative regulation of heart rate (GO:0010459)4.16676292
12T-helper cell differentiation (GO:0042093)4.16081988
13CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.16081988
14positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.13329070
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.06975375
16regulation of regulatory T cell differentiation (GO:0045589)3.94898640
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.86858857
18lymphocyte costimulation (GO:0031294)3.78527659
19T cell differentiation involved in immune response (GO:0002292)3.78376953
20alpha-beta T cell differentiation involved in immune response (GO:0002293)3.78376953
21alpha-beta T cell activation involved in immune response (GO:0002287)3.78376953
22cellular response to interleukin-15 (GO:0071350)3.69374090
23negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66108023
24regulation of immunoglobulin secretion (GO:0051023)3.65106244
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63266388
26positive regulation of granulocyte differentiation (GO:0030854)3.62059617
27T cell costimulation (GO:0031295)3.53600261
28positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.50125021
29interferon-gamma-mediated signaling pathway (GO:0060333)3.48074068
30protein neddylation (GO:0045116)3.42559285
31regulation of isotype switching to IgG isotypes (GO:0048302)3.41146792
32regulation of hypersensitivity (GO:0002883)3.37290402
33response to interleukin-15 (GO:0070672)3.34044590
34regulation of chronic inflammatory response (GO:0002676)3.29585250
35CD4-positive, alpha-beta T cell activation (GO:0035710)3.23741794
36regulation of T-helper 1 cell differentiation (GO:0045625)3.21358680
37CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.19219994
38S-adenosylmethionine metabolic process (GO:0046500)3.17893741
39regulation of cytokine production involved in inflammatory response (GO:1900015)3.15270371
40respiratory chain complex IV assembly (GO:0008535)3.13817132
41cellular response to interferon-beta (GO:0035458)3.09784955
42negative regulation of alpha-beta T cell differentiation (GO:0046639)3.07090702
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04494523
44T cell activation involved in immune response (GO:0002286)3.04429351
45alpha-beta T cell differentiation (GO:0046632)3.01306827
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00102257
47T cell receptor signaling pathway (GO:0050852)2.99998740
48antigen receptor-mediated signaling pathway (GO:0050851)2.98784747
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97936038
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97936038
51negative T cell selection (GO:0043383)2.96596594
52alpha-beta T cell activation (GO:0046631)2.93317639
53cellular response to interferon-gamma (GO:0071346)2.91558089
54immunoglobulin mediated immune response (GO:0016064)2.90541040
55rRNA modification (GO:0000154)2.90391532
56termination of RNA polymerase III transcription (GO:0006386)2.89266331
57transcription elongation from RNA polymerase III promoter (GO:0006385)2.89266331
58T cell lineage commitment (GO:0002360)2.88476123
59positive regulation of immunoglobulin production (GO:0002639)2.86631088
60B cell mediated immunity (GO:0019724)2.85156723
61chaperone-mediated protein transport (GO:0072321)2.84747715
62positive regulation of DNA recombination (GO:0045911)2.84635138
63positive regulation of activated T cell proliferation (GO:0042104)2.84331304
64positive regulation of isotype switching (GO:0045830)2.83562670
65cytokine biosynthetic process (GO:0042089)2.83225634
66positive T cell selection (GO:0043368)2.81706070
67regulation of interleukin-2 biosynthetic process (GO:0045076)2.81364689
68negative regulation of acute inflammatory response (GO:0002674)2.80766347
69chaperone mediated protein folding requiring cofactor (GO:0051085)2.79319397
70regulation of MHC class II biosynthetic process (GO:0045346)2.77357230
71rRNA methylation (GO:0031167)2.76834943
72positive regulation of B cell mediated immunity (GO:0002714)2.76290971
73positive regulation of immunoglobulin mediated immune response (GO:0002891)2.76290971
74positive regulation of chemokine biosynthetic process (GO:0045080)2.73691257
75actin nucleation (GO:0045010)2.73687079
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.73118615
77mannosylation (GO:0097502)2.70611802
78regulation of B cell proliferation (GO:0030888)2.70350638
79energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70280154
80ATP synthesis coupled proton transport (GO:0015986)2.70280154
81regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.69703139
82mast cell activation involved in immune response (GO:0002279)2.68311527
83mast cell degranulation (GO:0043303)2.68311527
84positive regulation of B cell proliferation (GO:0030890)2.67716157
85piRNA metabolic process (GO:0034587)2.65834062
86negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63851713
87response to interferon-beta (GO:0035456)2.63501482
88negative regulation of T cell differentiation (GO:0045581)2.61244399
89positive regulation of natural killer cell differentiation (GO:0032825)2.60504199
90mast cell activation (GO:0045576)2.59302718
91Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56800555
92positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.56164706
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55645929
94neutrophil activation involved in immune response (GO:0002283)2.55550069
95regulation of B cell receptor signaling pathway (GO:0050855)2.55257847
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55095866
97positive regulation of B cell differentiation (GO:0045579)2.54587009
98G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.53174364
99pseudouridine synthesis (GO:0001522)2.52434836
100positive regulation of T cell proliferation (GO:0042102)2.52025995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.05600462
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.63342536
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.46109407
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79511239
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50884853
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.30576702
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18716725
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09664263
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88956168
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.63899131
11VDR_22108803_ChIP-Seq_LS180_Human2.46392869
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.34187117
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32182856
14VDR_23849224_ChIP-Seq_CD4+_Human2.24711151
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18057063
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15494332
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13124538
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10679526
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.02693269
20MYB_26560356_Chip-Seq_TH2_Human1.96504945
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94824856
22IRF1_19129219_ChIP-ChIP_H3396_Human1.91349824
23FOXP3_21729870_ChIP-Seq_TREG_Human1.89857817
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.88917678
25CIITA_25753668_ChIP-Seq_RAJI_Human1.75309408
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71469059
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69883506
28GATA3_26560356_Chip-Seq_TH2_Human1.68223439
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66653877
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64447042
31ELK1_19687146_ChIP-ChIP_HELA_Human1.64327913
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62748201
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51365844
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49276460
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47390763
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.44597520
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.40747890
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36367863
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36259878
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35408550
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31584567
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30173854
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29976846
44TAF15_26573619_Chip-Seq_HEK293_Human1.27069164
45GATA3_27048872_Chip-Seq_THYMUS_Human1.26315399
46SOX2_19829295_ChIP-Seq_ESCs_Human1.26223838
47NANOG_19829295_ChIP-Seq_ESCs_Human1.26223838
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.23926618
49HTT_18923047_ChIP-ChIP_STHdh_Human1.22091191
50AR_20517297_ChIP-Seq_VCAP_Human1.19581301
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17980583
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17762240
53EZH2_22144423_ChIP-Seq_EOC_Human1.12963628
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12466057
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11229247
56RBPJ_21746931_ChIP-Seq_IB4_Human1.11035894
57FUS_26573619_Chip-Seq_HEK293_Human1.10616304
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.08983255
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08983255
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.08738417
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07209628
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06702938
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.06243344
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.06166875
65ZNF274_21170338_ChIP-Seq_K562_Hela1.05812102
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.05158859
67DCP1A_22483619_ChIP-Seq_HELA_Human1.03929338
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.03810985
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03314212
70RUNX_20019798_ChIP-Seq_JUKART_Human1.02940377
71GATA3_26560356_Chip-Seq_TH1_Human1.02643438
72MYC_18940864_ChIP-ChIP_HL60_Human1.01561550
73FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99898620
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99561280
75OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97491530
76MYB_26560356_Chip-Seq_TH1_Human0.97254179
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95888019
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95596805
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.94983491
80EWS_26573619_Chip-Seq_HEK293_Human0.94646247
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94567694
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92933335
83SPI1_23547873_ChIP-Seq_NB4_Human0.92810092
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92474571
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91685678
86IGF1R_20145208_ChIP-Seq_DFB_Human0.89843909
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88760057
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88168109
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88000944
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87432161
91TP53_22573176_ChIP-Seq_HFKS_Human0.87225232
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86751970
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86684922
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86393568
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85414682
96HOXB7_26014856_ChIP-Seq_BT474_Human0.84677661
97MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84368173
98ERG_20517297_ChIP-Seq_VCAP_Human0.82525717
99P300_19829295_ChIP-Seq_ESCs_Human0.80933158
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80858502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.96917910
2MP0005671_abnormal_response_to4.20861089
3MP0001873_stomach_inflammation3.94255744
4MP0002166_altered_tumor_susceptibility3.06549641
5MP0002148_abnormal_hypersensitivity_rea3.03358233
6MP0001800_abnormal_humoral_immune2.72413415
7MP0005451_abnormal_body_composition2.59782543
8MP0006072_abnormal_retinal_apoptosis2.58977220
9MP0000372_irregular_coat_pigmentation2.54118311
10MP0005000_abnormal_immune_tolerance2.48634046
11MP0008875_abnormal_xenobiotic_pharmacok2.46413662
12MP0002006_tumorigenesis2.36809151
13MP0005387_immune_system_phenotype2.32139826
14MP0001790_abnormal_immune_system2.32139826
15MP0000685_abnormal_immune_system2.22086131
16MP0003724_increased_susceptibility_to2.20247937
17MP0003806_abnormal_nucleotide_metabolis2.16694784
18MP0005075_abnormal_melanosome_morpholog2.16111472
19MP0009785_altered_susceptibility_to2.15487112
20MP0002723_abnormal_immune_serum2.10133429
21MP0001348_abnormal_lacrimal_gland2.09314978
22MP0009333_abnormal_splenocyte_physiolog1.95215310
23MP0002452_abnormal_antigen_presenting1.92540406
24MP0002102_abnormal_ear_morphology1.89889290
25MP0006082_CNS_inflammation1.82799589
26MP0002420_abnormal_adaptive_immunity1.82097527
27MP0001853_heart_inflammation1.81467316
28MP0001819_abnormal_immune_cell1.78324976
29MP0005408_hypopigmentation1.74895277
30MP0001905_abnormal_dopamine_level1.70369244
31MP0002009_preneoplasia1.70134872
32MP0009764_decreased_sensitivity_to1.68958519
33MP0008872_abnormal_physiological_respon1.68256985
34MP0003763_abnormal_thymus_physiology1.65690437
35MP0006036_abnormal_mitochondrial_physio1.63514723
36MP0003866_abnormal_defecation1.63425709
37MP0010155_abnormal_intestine_physiology1.62139741
38MP0005025_abnormal_response_to1.58988037
39MP0008877_abnormal_DNA_methylation1.57862859
40MP0005464_abnormal_platelet_physiology1.52333316
41MP0002398_abnormal_bone_marrow1.52107560
42MP0001845_abnormal_inflammatory_respons1.48922762
43MP0000716_abnormal_immune_system1.44952730
44MP0003186_abnormal_redox_activity1.41394592
45MP0000689_abnormal_spleen_morphology1.40161666
46MP0002933_joint_inflammation1.36181944
47MP0004043_abnormal_pH_regulation1.27906248
48MP0005310_abnormal_salivary_gland1.24714502
49MP0006035_abnormal_mitochondrial_morpho1.22791182
50MP0002429_abnormal_blood_cell1.21792552
51MP0002693_abnormal_pancreas_physiology1.20503229
52MP0005253_abnormal_eye_physiology1.18243467
53MP0008995_early_reproductive_senescence1.16460785
54MP0005397_hematopoietic_system_phenotyp1.15786609
55MP0001545_abnormal_hematopoietic_system1.15786609
56MP0004381_abnormal_hair_follicle1.14371566
57MP0002234_abnormal_pharynx_morphology1.14055042
58MP0002419_abnormal_innate_immunity1.11533883
59MP0002722_abnormal_immune_system1.10955173
60MP0002396_abnormal_hematopoietic_system1.04065499
61MP0002876_abnormal_thyroid_physiology1.01389986
62MP0003880_abnormal_central_pattern1.01383312
63MP0003718_maternal_effect1.00116217
64MP0001502_abnormal_circadian_rhythm0.98775406
65MP0008469_abnormal_protein_level0.97875925
66MP0003786_premature_aging0.97841596
67MP0001663_abnormal_digestive_system0.91928165
68MP0005636_abnormal_mineral_homeostasis0.86346253
69MP0000703_abnormal_thymus_morphology0.86074068
70MP0003221_abnormal_cardiomyocyte_apopto0.85785560
71MP0008058_abnormal_DNA_repair0.84842131
72MP0005166_decreased_susceptibility_to0.84815757
73MP0002019_abnormal_tumor_incidence0.83322090
74MP0003137_abnormal_impulse_conducting0.82552685
75MP0005645_abnormal_hypothalamus_physiol0.81634495
76MP0004142_abnormal_muscle_tone0.80773502
77MP0004145_abnormal_muscle_electrophysio0.80649122
78MP0006054_spinal_hemorrhage0.79303825
79MP0009765_abnormal_xenobiotic_induced0.76480230
80MP0003638_abnormal_response/metabolism_0.76168475
81MP0003646_muscle_fatigue0.75948675
82MP0009763_increased_sensitivity_to0.75641361
83MP0005410_abnormal_fertilization0.72301488
84MP0006276_abnormal_autonomic_nervous0.70736097
85MP0004947_skin_inflammation0.68150879
86MP0001765_abnormal_ion_homeostasis0.66432304
87MP0005551_abnormal_eye_electrophysiolog0.65744136
88MP0002163_abnormal_gland_morphology0.64144003
89MP0008873_increased_physiological_sensi0.63634814
90MP0003172_abnormal_lysosome_physiology0.63600417
91MP0002277_abnormal_respiratory_mucosa0.63335782
92MP0003075_altered_response_to0.63207648
93MP0003436_decreased_susceptibility_to0.63069799
94MP0001919_abnormal_reproductive_system0.61670527
95MP0001188_hyperpigmentation0.60096527
96MP0005646_abnormal_pituitary_gland0.59644597
97MP0003693_abnormal_embryo_hatching0.57949196
98MP0000015_abnormal_ear_pigmentation0.57919973
99MP0009643_abnormal_urine_homeostasis0.57518224
100MP0000858_altered_metastatic_potential0.56283569

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.23599363
2Abnormality of the prostate (HP:0008775)3.99584372
3Facial diplegia (HP:0001349)3.87006317
4Increased hepatocellular lipid droplets (HP:0006565)3.85244248
5Chronic mucocutaneous candidiasis (HP:0002728)3.66395526
6Recurrent cutaneous fungal infections (HP:0011370)3.66395526
7Lipid accumulation in hepatocytes (HP:0006561)3.66133972
8Mitochondrial inheritance (HP:0001427)3.48166494
9Elevated erythrocyte sedimentation rate (HP:0003565)3.40565089
10Aplastic anemia (HP:0001915)3.37915958
11Alveolar cell carcinoma (HP:0006519)3.37753471
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33031585
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33031585
14Stomatitis (HP:0010280)3.32004907
15Increased intramyocellular lipid droplets (HP:0012240)3.30297102
16Acute necrotizing encephalopathy (HP:0006965)3.19686123
17Hepatocellular necrosis (HP:0001404)3.15708968
18Chronic diarrhea (HP:0002028)3.13179563
193-Methylglutaconic aciduria (HP:0003535)3.09047547
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06587198
21Increased CSF lactate (HP:0002490)3.02821971
22Increased serum lactate (HP:0002151)2.98510586
23Acute encephalopathy (HP:0006846)2.89818613
24Neoplasm of the tracheobronchial system (HP:0100552)2.81401504
25Progressive macrocephaly (HP:0004481)2.81312348
26Hepatic necrosis (HP:0002605)2.80923459
27Increased muscle lipid content (HP:0009058)2.80258120
28Exertional dyspnea (HP:0002875)2.80009921
29IgA deficiency (HP:0002720)2.78639284
30Abnormal mitochondria in muscle tissue (HP:0008316)2.76483055
31Hemoptysis (HP:0002105)2.72394544
32Progressive inability to walk (HP:0002505)2.71416036
33Neoplasm of the adrenal cortex (HP:0100641)2.70294551
34Renal Fanconi syndrome (HP:0001994)2.69560530
35Pulmonary infiltrates (HP:0002113)2.63772083
36T lymphocytopenia (HP:0005403)2.59245843
37Nemaline bodies (HP:0003798)2.54386863
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53913191
39IgM deficiency (HP:0002850)2.53757093
40Pulmonary fibrosis (HP:0002206)2.53370806
41Increased IgM level (HP:0003496)2.53324109
42Pancreatic cysts (HP:0001737)2.52230173
43Lactic acidosis (HP:0003128)2.45536997
44Hypoproteinemia (HP:0003075)2.43595429
45Abnormality of T cell number (HP:0011839)2.41671132
46Aplasia/hypoplasia of the uterus (HP:0008684)2.40946244
47Abnormality of male internal genitalia (HP:0000022)2.39340030
48Oral leukoplakia (HP:0002745)2.33101871
49Dyschromatopsia (HP:0007641)2.32816258
50Hypoalbuminemia (HP:0003073)2.22298347
51Abnormal albumin level (HP:0012116)2.22298347
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18257192
53Microvesicular hepatic steatosis (HP:0001414)2.12746726
54Abnormality of T cells (HP:0002843)2.12532048
55Recurrent skin infections (HP:0001581)2.11612721
56Clubbing of toes (HP:0100760)2.08865261
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06393232
58Abolished electroretinogram (ERG) (HP:0000550)2.03941309
59Colon cancer (HP:0003003)2.03201739
60Cerebral edema (HP:0002181)2.03111210
61Palpitations (HP:0001962)2.02278435
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02176247
63Abnormality of alanine metabolism (HP:0010916)2.02176247
64Hyperalaninemia (HP:0003348)2.02176247
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.02150541
66Meningitis (HP:0001287)2.01670329
67Meckel diverticulum (HP:0002245)2.01068655
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.00799181
69Petechiae (HP:0000967)2.00549630
70Abnormality of the preputium (HP:0100587)2.00530315
71Agammaglobulinemia (HP:0004432)1.99939253
72Abnormality of the ileum (HP:0001549)1.96587153
73Abnormality of T cell physiology (HP:0011840)1.96161114
74Retrobulbar optic neuritis (HP:0100654)1.95975309
75Optic neuritis (HP:0100653)1.95975309
76Hypoplasia of the uterus (HP:0000013)1.95381819
77Recurrent fungal infections (HP:0002841)1.94840516
78Joint swelling (HP:0001386)1.92485378
79Polyneuropathy (HP:0001271)1.92008902
80Progressive microcephaly (HP:0000253)1.90709680
81Type 2 muscle fiber atrophy (HP:0003554)1.90296409
82Congenital stationary night blindness (HP:0007642)1.88128484
83Exercise intolerance (HP:0003546)1.87635495
84Muscle fiber inclusion bodies (HP:0100299)1.87607642
85Pancreatic fibrosis (HP:0100732)1.86662498
86Posterior subcapsular cataract (HP:0007787)1.83569799
87Spastic paraparesis (HP:0002313)1.82791344
88Amyotrophic lateral sclerosis (HP:0007354)1.82371897
89Large for gestational age (HP:0001520)1.82085473
90Gangrene (HP:0100758)1.81420018
91Abnormality of the anterior horn cell (HP:0006802)1.81235193
92Degeneration of anterior horn cells (HP:0002398)1.81235193
93Prostate neoplasm (HP:0100787)1.80544548
94Fatigue (HP:0012378)1.77236800
95Hypothermia (HP:0002045)1.77180462
96Congenital, generalized hypertrichosis (HP:0004540)1.75114643
97Leukodystrophy (HP:0002415)1.74877205
98Neoplasm of the respiratory system (HP:0100606)1.74739298
99Nuclear cataract (HP:0100018)1.74646129
100Ureteral stenosis (HP:0000071)1.73835444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.20511704
2TAOK34.70067170
3NUAK13.82813043
4MST43.29933937
5CDK192.89620101
6ZAK2.81180345
7BMPR22.40662863
8TLK12.34562213
9MAP4K22.11985412
10ADRBK22.07677141
11MKNK11.94924134
12VRK21.90761480
13CSF1R1.89117523
14MAP4K11.83606795
15MAPKAPK31.83011691
16MAPKAPK51.82362515
17PBK1.76515218
18KIT1.69794812
19MAP2K61.64994759
20TEC1.62237451
21IKBKB1.60896409
22TSSK61.57673442
23LATS11.54435743
24KDR1.43056149
25ITK1.40966896
26MAP3K141.39284072
27TRIM281.33291167
28OXSR11.31958428
29JAK31.31739067
30RIPK41.21412485
31BCKDK1.18807088
32BTK1.08479727
33SIK31.06129919
34FES1.03413336
35EIF2AK11.01743118
36VRK11.01615974
37MYLK1.00910030
38SRPK11.00803553
39GRK71.00782925
40CSNK1G20.99380567
41CSNK1G30.95629131
42SYK0.95352791
43AKT30.94479093
44MAP3K120.94429122
45IKBKE0.93966796
46EIF2AK30.93359076
47MAP3K130.92298574
48BMPR1B0.91652343
49DAPK30.87005490
50LCK0.84651469
51WNK10.80861939
52WNK40.79153021
53LYN0.78255775
54DAPK10.77766626
55CSNK1G10.74716516
56TNK20.72104335
57CCNB10.68807799
58GRK10.68059126
59FRK0.67919754
60PRKCQ0.63364284
61BUB10.63184102
62PIK3CG0.63175025
63TAF10.61034130
64IRAK40.60214226
65STK390.58827110
66TIE10.57546098
67GRK60.57217353
68CSNK1A1L0.56722868
69RPS6KA50.55899273
70CHUK0.53499597
71FLT30.53102371
72PIM10.51099713
73JAK20.48951012
74STK40.48456508
75BCR0.46787960
76TRPM70.46298793
77INSRR0.46052066
78GRK50.44487961
79IGF1R0.43187782
80PLK40.42854579
81DYRK30.42109616
82OBSCN0.40043575
83NME20.39529465
84TBK10.36901033
85JAK10.35463581
86ABL10.35324312
87MARK30.33886784
88TNIK0.33878727
89ADRBK10.33862237
90MAPKAPK20.33511168
91STK30.32182169
92MKNK20.29942602
93CSNK1A10.27782099
94CAMKK20.26458807
95CAMK2A0.25863211
96STK100.25702248
97HCK0.25606178
98TYK20.25543133
99DYRK20.23687630
100PLK30.23061284

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.28370385
2Autoimmune thyroid disease_Homo sapiens_hsa053205.16132985
3Allograft rejection_Homo sapiens_hsa053305.10904306
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.11706350
5Graft-versus-host disease_Homo sapiens_hsa053323.83811349
6Type I diabetes mellitus_Homo sapiens_hsa049403.56437245
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.48930683
8Proteasome_Homo sapiens_hsa030502.40506507
9Viral myocarditis_Homo sapiens_hsa054162.34372201
10Antigen processing and presentation_Homo sapiens_hsa046122.29757258
11RNA polymerase_Homo sapiens_hsa030202.04818245
12Rheumatoid arthritis_Homo sapiens_hsa053232.02248460
13Staphylococcus aureus infection_Homo sapiens_hsa051501.85321126
14Leishmaniasis_Homo sapiens_hsa051401.83551605
15Hematopoietic cell lineage_Homo sapiens_hsa046401.76389964
16Primary immunodeficiency_Homo sapiens_hsa053401.69733178
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68723311
18Oxidative phosphorylation_Homo sapiens_hsa001901.61656971
19One carbon pool by folate_Homo sapiens_hsa006701.53502631
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33617326
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27698284
22Systemic lupus erythematosus_Homo sapiens_hsa053221.26162552
23Parkinsons disease_Homo sapiens_hsa050121.23549331
24Selenocompound metabolism_Homo sapiens_hsa004501.22424069
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13801139
26Linoleic acid metabolism_Homo sapiens_hsa005911.03717376
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00860550
28Toxoplasmosis_Homo sapiens_hsa051450.99435558
29Ribosome_Homo sapiens_hsa030100.96668670
30Epstein-Barr virus infection_Homo sapiens_hsa051690.93476481
31Regulation of autophagy_Homo sapiens_hsa041400.92431343
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91710510
33Herpes simplex infection_Homo sapiens_hsa051680.91265959
34Phototransduction_Homo sapiens_hsa047440.91236783
35T cell receptor signaling pathway_Homo sapiens_hsa046600.90058256
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89514239
37Protein export_Homo sapiens_hsa030600.87768292
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.79580947
39Nitrogen metabolism_Homo sapiens_hsa009100.78776822
40Measles_Homo sapiens_hsa051620.75449546
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.69209038
42RNA degradation_Homo sapiens_hsa030180.65519923
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65292591
44Influenza A_Homo sapiens_hsa051640.64943329
45Collecting duct acid secretion_Homo sapiens_hsa049660.63671621
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62392325
47Tuberculosis_Homo sapiens_hsa051520.61180544
48Spliceosome_Homo sapiens_hsa030400.59763073
49Mismatch repair_Homo sapiens_hsa034300.57932742
50Fatty acid elongation_Homo sapiens_hsa000620.57023076
51Alzheimers disease_Homo sapiens_hsa050100.56647454
52Purine metabolism_Homo sapiens_hsa002300.56534358
53Pyrimidine metabolism_Homo sapiens_hsa002400.53485032
54Arachidonic acid metabolism_Homo sapiens_hsa005900.52003856
55Homologous recombination_Homo sapiens_hsa034400.49560952
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49199917
57Cardiac muscle contraction_Homo sapiens_hsa042600.48608982
58Huntingtons disease_Homo sapiens_hsa050160.47557276
59Phagosome_Homo sapiens_hsa041450.46453119
60Fanconi anemia pathway_Homo sapiens_hsa034600.44101451
61Tryptophan metabolism_Homo sapiens_hsa003800.41853329
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41108744
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40525974
64Ether lipid metabolism_Homo sapiens_hsa005650.39246053
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36850197
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.36136857
67Basal transcription factors_Homo sapiens_hsa030220.36022594
68RNA transport_Homo sapiens_hsa030130.33916738
69Legionellosis_Homo sapiens_hsa051340.30161453
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28941161
71Chemical carcinogenesis_Homo sapiens_hsa052040.28299713
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28050169
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.27289921
74Nucleotide excision repair_Homo sapiens_hsa034200.27198758
75Propanoate metabolism_Homo sapiens_hsa006400.26592827
76Peroxisome_Homo sapiens_hsa041460.24759696
77Platelet activation_Homo sapiens_hsa046110.24354024
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23216563
79Sulfur metabolism_Homo sapiens_hsa009200.22416554
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19443624
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19029416
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18478614
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18219482
84HTLV-I infection_Homo sapiens_hsa051660.18181577
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17991663
86Shigellosis_Homo sapiens_hsa051310.16882798
87Retinol metabolism_Homo sapiens_hsa008300.16650931
88Chemokine signaling pathway_Homo sapiens_hsa040620.16130156
89Non-homologous end-joining_Homo sapiens_hsa034500.15627594
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13952372
91Ovarian steroidogenesis_Homo sapiens_hsa049130.13363854
92Base excision repair_Homo sapiens_hsa034100.11272297
93Butanoate metabolism_Homo sapiens_hsa006500.09810234
94Metabolic pathways_Homo sapiens_hsa011000.09561639
95Vitamin digestion and absorption_Homo sapiens_hsa049770.09221279
96p53 signaling pathway_Homo sapiens_hsa041150.07683122
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07682572
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07466547
99Taste transduction_Homo sapiens_hsa047420.07086338
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06843489

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