TPM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)4.62685790
2cell adhesion mediated by integrin (GO:0033627)4.41110989
3protein localization to endosome (GO:0036010)4.32325590
4wound healing, spreading of epidermal cells (GO:0035313)4.21440049
5collagen fibril organization (GO:0030199)4.01378124
6barbed-end actin filament capping (GO:0051016)3.96319487
7endodermal cell differentiation (GO:0035987)3.73475426
8wound healing, spreading of cells (GO:0044319)3.63584674
9protein retention in ER lumen (GO:0006621)3.59618933
10hypotonic response (GO:0006971)3.53296686
11extracellular fibril organization (GO:0043206)3.46299169
12positive regulation of endothelial cell apoptotic process (GO:2000353)3.40297242
13axon extension involved in axon guidance (GO:0048846)3.40049113
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.40049113
15vascular endothelial growth factor signaling pathway (GO:0038084)3.33016991
16adherens junction assembly (GO:0034333)3.31581309
17hippo signaling (GO:0035329)3.28729067
18regulation of tight junction assembly (GO:2000810)3.27306796
19sequestering of extracellular ligand from receptor (GO:0035581)3.27010980
20cellular response to interferon-alpha (GO:0035457)3.25692074
21type B pancreatic cell proliferation (GO:0044342)3.23517136
22protein heterotrimerization (GO:0070208)3.22504932
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21135252
24fibril organization (GO:0097435)3.19509742
25mesodermal cell differentiation (GO:0048333)3.17334085
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16547657
27regulation of early endosome to late endosome transport (GO:2000641)3.15649167
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.15582732
29skin morphogenesis (GO:0043589)3.15499697
30cell-substrate adherens junction assembly (GO:0007045)3.14547180
31focal adhesion assembly (GO:0048041)3.14547180
32negative regulation of fatty acid transport (GO:2000192)3.14086936
33substrate-dependent cell migration (GO:0006929)3.12225244
34positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11321471
35pinocytosis (GO:0006907)3.07809434
36basement membrane organization (GO:0071711)3.03162186
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99281958
38vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.98646119
39regulation of integrin-mediated signaling pathway (GO:2001044)2.97547862
40kidney mesenchyme development (GO:0072074)2.96961101
41retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96109127
42COPI coating of Golgi vesicle (GO:0048205)2.95821422
43Golgi transport vesicle coating (GO:0048200)2.95821422
44morphogenesis of an endothelium (GO:0003159)2.94379254
45endothelial tube morphogenesis (GO:0061154)2.94379254
46heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.91782082
47adhesion of symbiont to host cell (GO:0044650)2.90594964
48virion attachment to host cell (GO:0019062)2.90594964
49cortical actin cytoskeleton organization (GO:0030866)2.87780752
50extracellular matrix assembly (GO:0085029)2.85762702
51regulation of SMAD protein import into nucleus (GO:0060390)2.82714008
52epithelial cell-cell adhesion (GO:0090136)2.81728525
53endothelial cell morphogenesis (GO:0001886)2.81445468
54hyaluronan catabolic process (GO:0030214)2.80390019
55cell migration involved in sprouting angiogenesis (GO:0002042)2.78796034
56sprouting angiogenesis (GO:0002040)2.77520147
57apoptotic cell clearance (GO:0043277)2.76593662
58substrate adhesion-dependent cell spreading (GO:0034446)2.76554355
59actin filament depolymerization (GO:0030042)2.76073099
60adhesion of symbiont to host (GO:0044406)2.71176940
61chondrocyte development (GO:0002063)2.70001745
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69948038
63negative regulation of chondrocyte differentiation (GO:0032331)2.66333759
64endocytic recycling (GO:0032456)2.66326889
65regulation of anoikis (GO:2000209)2.64388400
66positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.62450561
67protein localization to cell surface (GO:0034394)2.61594756
68cellular response to vitamin D (GO:0071305)2.60744591
69muscle cell migration (GO:0014812)2.59745014
70positive regulation of endothelial cell migration (GO:0010595)2.59510754
71positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58025091
72regulation of extracellular matrix disassembly (GO:0010715)2.57264866
73mesenchymal-epithelial cell signaling (GO:0060638)2.56866385
74venous blood vessel morphogenesis (GO:0048845)2.56633688
75positive regulation of receptor recycling (GO:0001921)2.56329916
76collagen metabolic process (GO:0032963)2.55627871
77cortical cytoskeleton organization (GO:0030865)2.55198070
78membrane protein ectodomain proteolysis (GO:0006509)2.54678644
79cellular response to vitamin (GO:0071295)2.54550497
80extracellular matrix organization (GO:0030198)2.53257425
81protein maturation by protein folding (GO:0022417)2.52975456
82regulation of integrin activation (GO:0033623)2.52854331
83extracellular structure organization (GO:0043062)2.52154746
84vesicle coating (GO:0006901)2.51471798
85negative regulation of adherens junction organization (GO:1903392)2.51388498
86negative regulation of focal adhesion assembly (GO:0051895)2.51388498
87negative regulation of cell junction assembly (GO:1901889)2.51388498
88SMAD protein complex assembly (GO:0007183)2.51378739
89bone trabecula formation (GO:0060346)2.51216262
90negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.50927707
91peptidyl-proline hydroxylation (GO:0019511)2.50796930
92nuclear pore complex assembly (GO:0051292)2.50731897
93lymphangiogenesis (GO:0001946)2.50030988
94cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48687432
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46629902
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.46095165
97endocardial cushion development (GO:0003197)2.42920139
98membrane raft organization (GO:0031579)2.42465466
99blood vessel endothelial cell migration (GO:0043534)2.41801684
100epithelial to mesenchymal transition (GO:0001837)2.41277312
101cell migration involved in heart development (GO:0060973)2.39865930
102regulation of protein heterodimerization activity (GO:0043497)2.39088867
103renal filtration (GO:0097205)2.38704053
104collagen catabolic process (GO:0030574)2.38566568
105hemidesmosome assembly (GO:0031581)2.36116968
106extracellular matrix disassembly (GO:0022617)2.35825068
107lymph vessel development (GO:0001945)2.35464740
108stress fiber assembly (GO:0043149)2.34862874
109multicellular organismal macromolecule metabolic process (GO:0044259)2.34806256
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34380131
111protein hydroxylation (GO:0018126)2.31326194
112regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.31092623
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30796529
114positive regulation of actin filament depolymerization (GO:0030836)2.29121324
115platelet aggregation (GO:0070527)2.28539143
116regulation of transforming growth factor beta2 production (GO:0032909)2.28178419
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.27804875
118nuclear pore organization (GO:0006999)2.27516671
119positive regulation of macrophage activation (GO:0043032)2.26515039
120maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26352352
121craniofacial suture morphogenesis (GO:0097094)2.25986125
122endothelial cell proliferation (GO:0001935)2.25871268
123response to laminar fluid shear stress (GO:0034616)2.25790242
124establishment of endothelial barrier (GO:0061028)2.25274902
125regulation of mitotic spindle organization (GO:0060236)2.21858437
126negative regulation of smooth muscle cell migration (GO:0014912)2.21805720
127paraxial mesoderm development (GO:0048339)2.21444859
128cell-substrate junction assembly (GO:0007044)2.20404119
129germ cell migration (GO:0008354)2.19717815
130multicellular organismal metabolic process (GO:0044236)2.19687403
131negative regulation of cartilage development (GO:0061037)2.19561300
132negative regulation of anoikis (GO:2000811)2.19459387
133regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.18509526
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.17907525
135positive regulation of osteoblast proliferation (GO:0033690)2.17463936
136positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.17139453
137response to fluid shear stress (GO:0034405)2.16846165
138wound healing (GO:0042060)2.16767081
139multicellular organismal catabolic process (GO:0044243)2.16144795
140plasma membrane repair (GO:0001778)2.16070079
141cell proliferation involved in metanephros development (GO:0072203)2.15905271
142regulation of heart morphogenesis (GO:2000826)2.15408869
143glomerular basement membrane development (GO:0032836)2.14704988
144histone-serine phosphorylation (GO:0035404)2.14323600
145atrioventricular valve morphogenesis (GO:0003181)2.14147991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.19758048
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.86290832
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.24609281
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.00704619
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.83477599
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68389519
7E2F7_22180533_ChIP-Seq_HELA_Human3.56998997
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37309546
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.07049767
10CLOCK_20551151_ChIP-Seq_293T_Human3.01986945
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.58361347
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.42633794
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39627773
14* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.15900499
15* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.15900499
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.15264559
17* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14194200
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12838733
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.10243115
20BRD4_25478319_ChIP-Seq_HGPS_Human2.07863665
21* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04096825
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03893384
23AR_21909140_ChIP-Seq_LNCAP_Human1.99643957
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92259763
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.91769221
26* CJUN_26792858_Chip-Seq_BT549_Human1.87785491
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75320355
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73677481
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69946784
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67180062
31* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66887377
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65966418
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62971126
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59583417
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56547665
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.53215914
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.52638979
38ATF3_27146783_Chip-Seq_COLON_Human1.50307089
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50270054
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49697661
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49090171
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48304916
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47473397
44ELK1_19687146_ChIP-ChIP_HELA_Human1.47359897
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45867665
46* UBF1/2_26484160_Chip-Seq_HMECs_Human1.45069625
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44861910
48* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43472293
49* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42740011
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38543403
51* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37250452
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.37118240
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36293135
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34858172
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34768252
56ZNF263_19887448_ChIP-Seq_K562_Human1.34527120
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34337953
58SOX2_20726797_ChIP-Seq_SW620_Human1.33629362
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31238518
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29985123
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29633751
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28820114
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28054826
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.27905503
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.27810425
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26099675
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.25599902
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.24564640
69* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24236542
70* LXR_22292898_ChIP-Seq_THP-1_Human1.22627171
71* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22243142
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22155378
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20884001
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20050881
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.18704091
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18357584
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17869473
78* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17050084
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16183945
80TCF7_22412390_ChIP-Seq_EML_Mouse1.15993779
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.15153592
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.15153592
83KDM2B_26808549_Chip-Seq_K562_Human1.14498577
84* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13890055
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13344195
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13321668
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11485382
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11485382
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11469329
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10784887
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10170564
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.10113871
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09293034
94MYC_22102868_ChIP-Seq_BL_Human1.08888214
95TFEB_21752829_ChIP-Seq_HELA_Human1.08551710
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07292838
97* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05553946
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.04755185
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04447433
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04124199
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02235206
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.02188259
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.01966830
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01773030
105TP53_22127205_ChIP-Seq_IMR90_Human1.01626525
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01100514
107KDM2B_26808549_Chip-Seq_DND41_Human0.99125423
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98178253
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.98027809
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97159549
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97113766
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.96318803
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96257189
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96166378
115* MAF_26560356_Chip-Seq_TH1_Human0.95331970
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94610654
117* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94335673
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93882969
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93164266
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93066858
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93021311
122* RACK7_27058665_Chip-Seq_MCF-7_Human0.92746923
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91693200
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91560177
125* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91124851
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90918582
127* MYB_26560356_Chip-Seq_TH2_Human0.89299392
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88170858
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86660157
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.86117368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.37672491
2MP0003705_abnormal_hypodermis_morpholog4.09092833
3MP0005275_abnormal_skin_tensile3.63001185
4MP0005503_abnormal_tendon_morphology3.15992686
5MP0003279_aneurysm2.91708964
6MP0010352_gastrointestinal_tract_polyps2.80711499
7MP0004272_abnormal_basement_membrane2.74929178
8MP0003566_abnormal_cell_adhesion2.50587874
9MP0006054_spinal_hemorrhage2.49259768
10MP0001958_emphysema2.42315088
11MP0005623_abnormal_meninges_morphology2.32831878
12MP0005023_abnormal_wound_healing2.15668211
13MP0010368_abnormal_lymphatic_system2.01768341
14MP0010030_abnormal_orbit_morphology1.94687340
15MP0003091_abnormal_cell_migration1.93204922
16MP0009384_cardiac_valve_regurgitation1.91125355
17MP0001879_abnormal_lymphatic_vessel1.80720576
18MP0009053_abnormal_anal_canal1.74111458
19MP0001849_ear_inflammation1.72548415
20MP0005076_abnormal_cell_differentiation1.53127683
21MP0002060_abnormal_skin_morphology1.51828122
22MP0000767_abnormal_smooth_muscle1.51087465
23MP0000733_abnormal_muscle_development1.50460295
24MP0005508_abnormal_skeleton_morphology1.48927498
25MP0005257_abnormal_intraocular_pressure1.43352575
26MP0003385_abnormal_body_wall1.43071245
27MP0003300_gastrointestinal_ulcer1.32193200
28MP0002877_abnormal_melanocyte_morpholog1.32031304
29MP0003941_abnormal_skin_development1.31850877
30MP0002295_abnormal_pulmonary_circulatio1.30599160
31MP0000537_abnormal_urethra_morphology1.27900408
32MP0001243_abnormal_dermal_layer1.26650299
33MP0010234_abnormal_vibrissa_follicle1.24959666
34MP0002282_abnormal_trachea_morphology1.24374891
35MP0009250_abnormal_appendicular_skeleto1.22259049
36MP0000858_altered_metastatic_potential1.18065801
37MP0003448_altered_tumor_morphology1.17136204
38MP0005409_darkened_coat_color1.14691427
39MP0008007_abnormal_cellular_replicative1.14520286
40MP0005595_abnormal_vascular_smooth1.13020344
41MP0004858_abnormal_nervous_system1.12264707
42MP0004808_abnormal_hematopoietic_stem1.12120748
43MP0003191_abnormal_cellular_cholesterol1.11714895
44MP0005390_skeleton_phenotype1.10724629
45MP0002896_abnormal_bone_mineralization1.09785994
46MP0001542_abnormal_bone_strength1.08826585
47MP0000762_abnormal_tongue_morphology1.07503210
48MP0005058_abnormal_lysosome_morphology1.06494457
49MP0010307_abnormal_tumor_latency1.04876088
50MP0001533_abnormal_skeleton_physiology1.03406785
51MP0003453_abnormal_keratinocyte_physiol1.02430953
52MP0003942_abnormal_urinary_system1.01542424
53MP0009278_abnormal_bone_marrow1.00260177
54MP0003828_pulmonary_edema0.99993277
55MP0002933_joint_inflammation0.99139809
56MP0001915_intracranial_hemorrhage0.98122685
57MP0001299_abnormal_eye_distance/0.95830895
58MP0002796_impaired_skin_barrier0.95434319
59MP0002925_abnormal_cardiovascular_devel0.94338003
60MP0009840_abnormal_foam_cell0.93400711
61MP0000003_abnormal_adipose_tissue0.93075478
62MP0003115_abnormal_respiratory_system0.92838000
63MP0001614_abnormal_blood_vessel0.92576956
64MP0002113_abnormal_skeleton_development0.92528823
65MP0000751_myopathy0.92461912
66MP0000428_abnormal_craniofacial_morphol0.91984685
67MP0005165_increased_susceptibility_to0.91972732
68MP0002128_abnormal_blood_circulation0.91198237
69MP0000343_altered_response_to0.90894814
70MP0009780_abnormal_chondrocyte_physiolo0.90706205
71MP0000163_abnormal_cartilage_morphology0.90500316
72MP0005197_abnormal_uvea_morphology0.90364655
73MP0005464_abnormal_platelet_physiology0.90146573
74MP0005501_abnormal_skin_physiology0.89957080
75MP0002115_abnormal_skeleton_extremities0.88740836
76MP0000516_abnormal_urinary_system0.88243384
77MP0005367_renal/urinary_system_phenotyp0.88243384
78MP0003950_abnormal_plasma_membrane0.88011269
79MP0005621_abnormal_cell_physiology0.87712176
80MP0003755_abnormal_palate_morphology0.85964642
81MP0004947_skin_inflammation0.85446340
82MP0000750_abnormal_muscle_regeneration0.85307065
83MP0000534_abnormal_ureter_morphology0.84960209
84MP0004197_abnormal_fetal_growth/weight/0.83685067
85MP0003937_abnormal_limbs/digits/tail_de0.83616621
86MP0004233_abnormal_muscle_weight0.83520254
87MP0002932_abnormal_joint_morphology0.83503942
88MP0002998_abnormal_bone_remodeling0.82898769
89MP0008004_abnormal_stomach_pH0.82771629
90MP0004510_myositis0.82596601
91MP0002086_abnormal_extraembryonic_tissu0.81873926
92MP0000013_abnormal_adipose_tissue0.80972544
93MP0003045_fibrosis0.80816474
94MP0004084_abnormal_cardiac_muscle0.80278203
95MP0003436_decreased_susceptibility_to0.78222490
96MP0000467_abnormal_esophagus_morphology0.77701856
97MP0001175_abnormal_lung_morphology0.77614653
98MP0001216_abnormal_epidermal_layer0.77002341
99MP0003935_abnormal_craniofacial_develop0.76973278
100MP0003984_embryonic_growth_retardation0.76804348
101MP0002088_abnormal_embryonic_growth/wei0.76328661
102MP0005164_abnormal_response_to0.75916886
103MP0002168_other_aberrant_phenotype0.75731984
104MP0003795_abnormal_bone_structure0.75616789
105MP0000350_abnormal_cell_proliferation0.74812520
106MP0000432_abnormal_head_morphology0.74628466
107MP0002166_altered_tumor_susceptibility0.73446436
108MP0004957_abnormal_blastocyst_morpholog0.72684995
109MP0000627_abnormal_mammary_gland0.72175818
110MP0001730_embryonic_growth_arrest0.72060179
111MP0003303_peritoneal_inflammation0.71616175
112MP0002006_tumorigenesis0.71165222
113MP0005193_abnormal_anterior_eye0.70941432
114MP0000249_abnormal_blood_vessel0.70480290
115MP0008932_abnormal_embryonic_tissue0.70026816
116MP0003077_abnormal_cell_cycle0.69045491
117MP0001672_abnormal_embryogenesis/_devel0.68808387
118MP0005380_embryogenesis_phenotype0.68808387
119MP0002108_abnormal_muscle_morphology0.68516283
120MP0002396_abnormal_hematopoietic_system0.68096601
121MP0002109_abnormal_limb_morphology0.67541148
122MP0003567_abnormal_fetal_cardiomyocyte0.66489918
123MP0001348_abnormal_lacrimal_gland0.65923129
124MP0010630_abnormal_cardiac_muscle0.65794973
125MP0000759_abnormal_skeletal_muscle0.65579702
126MP0006138_congestive_heart_failure0.65086318
127MP0010771_integument_phenotype0.65068735
128MP0000462_abnormal_digestive_system0.64816311
129MP0002089_abnormal_postnatal_growth/wei0.63887879
130MP0002133_abnormal_respiratory_system0.60772652
131MP0005388_respiratory_system_phenotype0.60772652
132MP0004134_abnormal_chest_morphology0.60597491

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.32650487
2Premature rupture of membranes (HP:0001788)6.07641253
3Aortic aneurysm (HP:0004942)4.30275806
4Aortic dissection (HP:0002647)4.15345072
5Shallow orbits (HP:0000586)3.93232507
6Cerebral aneurysm (HP:0004944)3.90514304
7Dilatation of the ascending aorta (HP:0005111)3.68878695
8Atrophic scars (HP:0001075)3.59496241
9Soft skin (HP:0000977)3.56241658
10Peritonitis (HP:0002586)3.54186693
11Cervical subluxation (HP:0003308)3.50297024
12Ankle contracture (HP:0006466)3.46763986
13Vertebral compression fractures (HP:0002953)3.08439637
14Wormian bones (HP:0002645)3.07649918
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.97364590
16Osteolytic defects of the hand bones (HP:0009699)2.97364590
17Abnormality of dentin (HP:0010299)2.95534973
18Bladder diverticulum (HP:0000015)2.94381824
19Vascular tortuosity (HP:0004948)2.90309426
20Wrist flexion contracture (HP:0001239)2.79902344
21Increased density of long bones (HP:0006392)2.78301298
22Blue sclerae (HP:0000592)2.75998857
23Fragile skin (HP:0001030)2.68468536
24Spinal rigidity (HP:0003306)2.62965468
25Mitral valve prolapse (HP:0001634)2.61507123
26Arterial tortuosity (HP:0005116)2.59543454
27Spinal cord lesions (HP:0100561)2.59264800
28Syringomyelia (HP:0003396)2.59264800
29Increased connective tissue (HP:0009025)2.58178764
30Broad metatarsal (HP:0001783)2.54970700
31Short 4th metacarpal (HP:0010044)2.53781363
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53781363
33Genu recurvatum (HP:0002816)2.52275766
34Short nail (HP:0001799)2.41254894
35Slender build (HP:0001533)2.40779819
36Biconcave vertebral bodies (HP:0004586)2.39557163
37Hyperacusis (HP:0010780)2.39539030
38Mesomelia (HP:0003027)2.39005374
39Aneurysm (HP:0002617)2.33356490
40Neonatal short-limb short stature (HP:0008921)2.32737145
41Distal lower limb amyotrophy (HP:0008944)2.28043822
42Ulnar bowing (HP:0003031)2.27068603
43Camptodactyly of toe (HP:0001836)2.26902237
44Mildly elevated creatine phosphokinase (HP:0008180)2.26260513
45Hematochezia (HP:0002573)2.25949370
46Abnormality of the calcaneus (HP:0008364)2.25832784
47Disproportionate tall stature (HP:0001519)2.25567845
48Increased variability in muscle fiber diameter (HP:0003557)2.25489002
49Radial bowing (HP:0002986)2.22693163
50Persistence of primary teeth (HP:0006335)2.20233470
51Achilles tendon contracture (HP:0001771)2.17914118
52Follicular hyperkeratosis (HP:0007502)2.17281719
53Bowel diverticulosis (HP:0005222)2.15976746
54Abnormality of the acetabulum (HP:0003170)2.15013140
55Abnormality of the peritoneum (HP:0002585)2.14345740
56Asymmetry of the thorax (HP:0001555)2.14312296
57Abnormality of skeletal muscle fiber size (HP:0012084)2.12660527
58Thin bony cortex (HP:0002753)2.11766165
59Elbow flexion contracture (HP:0002987)2.11409746
60Subacute progressive viral hepatitis (HP:0006572)2.08483103
61Increased mean platelet volume (HP:0011877)2.07757324
62Type 1 muscle fiber predominance (HP:0003803)2.03230529
63Selective tooth agenesis (HP:0001592)2.02881541
64Renal duplication (HP:0000075)2.01804302
65Overgrowth (HP:0001548)2.00377629
66Spondylolisthesis (HP:0003302)1.98590949
67Deviation of the hallux (HP:0010051)1.98495047
68Scapular winging (HP:0003691)1.97045573
69Abnormality of the Achilles tendon (HP:0005109)1.93909866
70Mitral regurgitation (HP:0001653)1.93552833
71Hallux valgus (HP:0001822)1.91713730
72Mitral stenosis (HP:0001718)1.91082920
73Long toe (HP:0010511)1.90141035
74Aortic valve stenosis (HP:0001650)1.89169953
75Hyperextensible skin (HP:0000974)1.87576123
76Abnormality of the 4th metacarpal (HP:0010012)1.87103735
77Joint laxity (HP:0001388)1.85792105
78Right ventricular cardiomyopathy (HP:0011663)1.84904688
79Broad face (HP:0000283)1.84532823
80Lower limb amyotrophy (HP:0007210)1.84275071
81Flexion contracture of toe (HP:0005830)1.83994948
82Joint contractures involving the joints of the feet (HP:0100492)1.83994948
83Bowed forearm bones (HP:0003956)1.83225372
84Bowing of the arm (HP:0006488)1.83225372
85Abnormal platelet volume (HP:0011876)1.82208033
86Thoracolumbar scoliosis (HP:0002944)1.81212237
87Abnormality of the distal phalanges of the toes (HP:0010182)1.80906796
88Generalized amyotrophy (HP:0003700)1.80784190
89Coxa vara (HP:0002812)1.80706093
90Absent frontal sinuses (HP:0002688)1.78856986
91Distal lower limb muscle weakness (HP:0009053)1.78497664
92Protruding ear (HP:0000411)1.77171317
93Fused cervical vertebrae (HP:0002949)1.77097358
94Abnormality of oral frenula (HP:0000190)1.77014652
95Tibial bowing (HP:0002982)1.76142698
96Cardiovascular calcification (HP:0011915)1.76075656
97Hypoventilation (HP:0002791)1.75535442
98Cupped ribs (HP:0000887)1.75026076
99Abnormal delivery (HP:0001787)1.74504184
100Deviation of the thumb (HP:0009603)1.72059128
101Joint stiffness (HP:0001387)1.71568307
102Bicuspid aortic valve (HP:0001647)1.70338031
103Abnormal ossification of hand bones (HP:0005921)1.70226992
104Coronal craniosynostosis (HP:0004440)1.69976339
105Abnormality of skull ossification (HP:0002703)1.69726338
106Delayed cranial suture closure (HP:0000270)1.69535360
107Broad long bones (HP:0005622)1.69058423
108Buphthalmos (HP:0000557)1.67993859
109Mild short stature (HP:0003502)1.67868625
110Long palpebral fissure (HP:0000637)1.67632193
111Nonimmune hydrops fetalis (HP:0001790)1.67393684
112Wide anterior fontanel (HP:0000260)1.67377472
113Broad ribs (HP:0000885)1.66550292
114Platyspondyly (HP:0000926)1.65902420
115Breech presentation (HP:0001623)1.65843808
116Myocardial infarction (HP:0001658)1.65752944
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64936363
118Back pain (HP:0003418)1.64868003
119Flat cornea (HP:0007720)1.64012734
120Tarsal synostosis (HP:0008368)1.63797090
121Knee flexion contracture (HP:0006380)1.62414070
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.61409648
123Spinal cord compression (HP:0002176)1.58424072
124Natal tooth (HP:0000695)1.58267057
125Delayed closure of the anterior fontanelle (HP:0001476)1.57160455
126Ectopia lentis (HP:0001083)1.57061843
127Aortic regurgitation (HP:0001659)1.56440034
128Round ear (HP:0100830)1.55948276
129Venous abnormality (HP:0002624)1.54164363
130Limited elbow extension (HP:0001377)1.53892856
131Rectal prolapse (HP:0002035)1.53471367
132Upper limb amyotrophy (HP:0009129)1.52828939
133Distal upper limb amyotrophy (HP:0007149)1.52828939
134Trismus (HP:0000211)1.52087596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.46933972
2TESK12.99040993
3TRIB32.91126772
4DDR22.55610043
5IRAK32.35921796
6RPS6KA42.33388020
7LATS12.26220642
8PDGFRA2.23376075
9NTRK12.17765001
10LIMK12.17466498
11KDR2.15416684
12LRRK22.04781928
13EPHA22.04331257
14STK101.94214016
15PKN21.93280061
16LATS21.92292126
17TGFBR11.79286028
18PRPF4B1.73375404
19NEK91.70706385
20TESK21.67762864
21EPHB21.66133999
22SMG11.62008416
23PAK41.60154588
24ERBB41.59194903
25TRPM71.57892035
26CDK121.57470142
27STK31.57361908
28ERBB31.57106180
29ERN11.55736512
30PAK21.53376233
31PTK61.49366731
32ICK1.47461799
33PIM21.45734441
34TGFBR21.45570814
35PTK21.39566681
36FER1.39480703
37RIPK11.34483528
38MST1R1.33144938
39EPHA31.32728516
40CDC42BPA1.32316809
41MAP3K31.30986515
42FRK1.27808242
43TIE11.13840918
44FGFR11.13399478
45MAP3K101.12145799
46MAP3K81.10176268
47JAK31.10108609
48BMX1.08998765
49DMPK1.05986073
50NME21.05533428
51SCYL21.04793318
52CDK61.03683376
53ILK1.02419557
54ARAF1.00140715
55TBK10.99563529
56ROCK20.98135957
57PIK3CA0.97942915
58PAK30.97495243
59MET0.94827666
60STK380.91496071
61PRKD20.91131165
62MAP2K30.90876671
63NUAK10.90773317
64NEK20.90566249
65ABL20.89024576
66PTK2B0.88458230
67PDGFRB0.88176577
68RPS6KA20.86548002
69MAP3K60.85519287
70MAP3K140.83857355
71RPS6KB20.80267049
72BRSK20.80172915
73LMTK20.79123302
74ZAK0.78304389
75FGFR30.78166437
76TYK20.77646190
77MOS0.76396404
78SIK10.73178759
79FGFR40.72970844
80PBK0.72968088
81ROCK10.72642601
82MYLK0.72527008
83CDC70.71503227
84MAP3K130.71499001
85CDK80.69094995
86BUB10.69088157
87AURKB0.67968643
88CHUK0.66966232
89PIK3CG0.64772586
90CLK10.64755808
91EEF2K0.64047104
92PLK30.63460319
93STK38L0.63244308
94MTOR0.62915729
95NEK10.62451626
96EIF2AK10.61994779
97JAK10.61596699
98PAK10.59995304
99FLT30.59971119
100STK240.58586178
101PRKG20.58539510
102MAP2K10.57423768
103DAPK30.57218701
104INSR0.55916537
105IKBKB0.54433292
106PASK0.53337773
107MST40.52792200
108TAOK20.52184094
109PLK20.50649825
110MAPKAPK20.50101248
111GSK3A0.49889627
112DYRK1B0.49621542
113EPHB10.49528632
114MKNK10.49394924
115KSR20.48010888
116ACVR1B0.46753289
117ZAP700.46015987
118MAP3K120.45950242
119CSK0.44692033
120MARK30.43863184
121PIM10.43778167
122MAPKAPK30.42978113
123MAP3K110.41823216
124CDK90.40751676
125STK40.40741267
126SIK30.39918978
127CDK140.39417331
128KSR10.39374634
129CDK150.39240645
130CDK180.39212643
131MELK0.39057953
132PAK60.38978982
133CDK70.38922585
134MAPK70.38116402
135CDK11A0.35390360
136BRAF0.31978766
137AKT30.31757258

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.55602445
2Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.48118883
3Focal adhesion_Homo sapiens_hsa045102.28299845
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.26202880
5Adherens junction_Homo sapiens_hsa045202.25923794
6Small cell lung cancer_Homo sapiens_hsa052222.06974271
7Proteoglycans in cancer_Homo sapiens_hsa052052.03629519
8Shigellosis_Homo sapiens_hsa051311.99709853
9Viral myocarditis_Homo sapiens_hsa054161.93327608
10Malaria_Homo sapiens_hsa051441.89671414
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85674528
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.84296172
13p53 signaling pathway_Homo sapiens_hsa041151.83387344
14MicroRNAs in cancer_Homo sapiens_hsa052061.78070621
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.77459718
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.73061709
17TGF-beta signaling pathway_Homo sapiens_hsa043501.65566393
18Hippo signaling pathway_Homo sapiens_hsa043901.60941336
19Leishmaniasis_Homo sapiens_hsa051401.60376357
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.55259776
21Chronic myeloid leukemia_Homo sapiens_hsa052201.54098619
22Bladder cancer_Homo sapiens_hsa052191.51846421
23Legionellosis_Homo sapiens_hsa051341.50836922
24Amoebiasis_Homo sapiens_hsa051461.48344754
25Toxoplasmosis_Homo sapiens_hsa051451.46141613
26TNF signaling pathway_Homo sapiens_hsa046681.45907899
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45590422
28Cell cycle_Homo sapiens_hsa041101.43307361
29Salmonella infection_Homo sapiens_hsa051321.34003804
30Apoptosis_Homo sapiens_hsa042101.33143902
31Viral carcinogenesis_Homo sapiens_hsa052031.31612499
32HTLV-I infection_Homo sapiens_hsa051661.31448279
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30204264
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27026652
35Pancreatic cancer_Homo sapiens_hsa052121.25362126
36Other glycan degradation_Homo sapiens_hsa005111.25177826
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.22796199
38Prion diseases_Homo sapiens_hsa050201.20585022
39Antigen processing and presentation_Homo sapiens_hsa046121.18496334
40Hepatitis B_Homo sapiens_hsa051611.16652270
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16156304
42* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12982424
43Measles_Homo sapiens_hsa051621.12893498
44Pertussis_Homo sapiens_hsa051331.11124345
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07239837
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06542558
47Osteoclast differentiation_Homo sapiens_hsa043801.05830347
48Tight junction_Homo sapiens_hsa045301.04420946
49Prostate cancer_Homo sapiens_hsa052151.02062331
50Basal cell carcinoma_Homo sapiens_hsa052171.00566300
51Pathways in cancer_Homo sapiens_hsa052001.00566091
52Platelet activation_Homo sapiens_hsa046110.99906925
53Phagosome_Homo sapiens_hsa041450.99173926
54HIF-1 signaling pathway_Homo sapiens_hsa040660.99147870
55Vibrio cholerae infection_Homo sapiens_hsa051100.97753224
56Melanoma_Homo sapiens_hsa052180.94678287
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94210904
58Non-small cell lung cancer_Homo sapiens_hsa052230.93802554
59Gap junction_Homo sapiens_hsa045400.93419620
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92795854
61Lysosome_Homo sapiens_hsa041420.92064299
62Colorectal cancer_Homo sapiens_hsa052100.91625893
63* Dilated cardiomyopathy_Homo sapiens_hsa054140.90937005
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89366185
65RNA transport_Homo sapiens_hsa030130.89305010
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87790409
67Epstein-Barr virus infection_Homo sapiens_hsa051690.87654325
68Hematopoietic cell lineage_Homo sapiens_hsa046400.87310659
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87240578
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87126941
71Rap1 signaling pathway_Homo sapiens_hsa040150.86891516
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.86532974
73Herpes simplex infection_Homo sapiens_hsa051680.86328126
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86311094
75Influenza A_Homo sapiens_hsa051640.84490355
76Protein digestion and absorption_Homo sapiens_hsa049740.83946960
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83453850
78Graft-versus-host disease_Homo sapiens_hsa053320.83431761
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83180541
80Proteasome_Homo sapiens_hsa030500.82551563
81Pentose phosphate pathway_Homo sapiens_hsa000300.81344557
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80709302
83Galactose metabolism_Homo sapiens_hsa000520.79851910
84Thyroid cancer_Homo sapiens_hsa052160.79846345
85Tuberculosis_Homo sapiens_hsa051520.77431917
86ErbB signaling pathway_Homo sapiens_hsa040120.76362082
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.75343027
88Renal cell carcinoma_Homo sapiens_hsa052110.75293178
89Hedgehog signaling pathway_Homo sapiens_hsa043400.73555751
90DNA replication_Homo sapiens_hsa030300.71446874
91VEGF signaling pathway_Homo sapiens_hsa043700.69836512
92Axon guidance_Homo sapiens_hsa043600.69612596
93Allograft rejection_Homo sapiens_hsa053300.67547387
94Systemic lupus erythematosus_Homo sapiens_hsa053220.67523463
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67269610
96Estrogen signaling pathway_Homo sapiens_hsa049150.67151527
97Endocytosis_Homo sapiens_hsa041440.66020631
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.65136790
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.65000918
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64745038
101GnRH signaling pathway_Homo sapiens_hsa049120.62607398
102Endometrial cancer_Homo sapiens_hsa052130.62055922
103Melanogenesis_Homo sapiens_hsa049160.62015488
104Glioma_Homo sapiens_hsa052140.61357577
105Prolactin signaling pathway_Homo sapiens_hsa049170.61110321
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.60061223
107N-Glycan biosynthesis_Homo sapiens_hsa005100.59439308
108Rheumatoid arthritis_Homo sapiens_hsa053230.59368369
109Ras signaling pathway_Homo sapiens_hsa040140.58335596
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56804333
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.56766523
112B cell receptor signaling pathway_Homo sapiens_hsa046620.56451366
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56149012
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56123371
115Wnt signaling pathway_Homo sapiens_hsa043100.55551700
116One carbon pool by folate_Homo sapiens_hsa006700.55178757
117FoxO signaling pathway_Homo sapiens_hsa040680.54116270
118Spliceosome_Homo sapiens_hsa030400.53393163
119Base excision repair_Homo sapiens_hsa034100.52816872
120Notch signaling pathway_Homo sapiens_hsa043300.52748633
121Hepatitis C_Homo sapiens_hsa051600.52094702
122Acute myeloid leukemia_Homo sapiens_hsa052210.51759652
123Chemokine signaling pathway_Homo sapiens_hsa040620.51006564
124Renin-angiotensin system_Homo sapiens_hsa046140.50718759
125Nucleotide excision repair_Homo sapiens_hsa034200.49354964
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49162445
127mTOR signaling pathway_Homo sapiens_hsa041500.48459678
128MAPK signaling pathway_Homo sapiens_hsa040100.48032864
129Choline metabolism in cancer_Homo sapiens_hsa052310.47376456
130Insulin signaling pathway_Homo sapiens_hsa049100.46494576
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43646222
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42059230

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