ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.16467499
2	gamma-aminobutyric acid transport (GO:0015812)	3.84170708
3	somite development (GO:0061053)	3.67239545
4	water-soluble vitamin biosynthetic process (GO:0042364)	3.60509548
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.56929038
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.56929038
7	NADH dehydrogenase complex assembly (GO:0010257)	3.56929038
8	protein complex biogenesis (GO:0070271)	3.34426153
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.30804932
10	sulfation (GO:0051923)	3.29425604
11	cell proliferation in forebrain (GO:0021846)	3.28515773
12	postsynaptic membrane organization (GO:0001941)	3.14769093
13	otic vesicle formation (GO:0030916)	3.12480739
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.10920781
15	indolalkylamine metabolic process (GO:0006586)	3.09672786
16	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.08178903
17	nonmotile primary cilium assembly (GO:0035058)	3.07610490
18	protein polyglutamylation (GO:0018095)	3.07081941
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.06431117
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.05457678
21	dendritic spine morphogenesis (GO:0060997)	3.05428034
22	protein neddylation (GO:0045116)	3.03755015
23	response to pheromone (GO:0019236)	3.02306200
24	detection of light stimulus involved in visual perception (GO:0050908)	3.00297436
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.00297436
26	regulation of cilium movement (GO:0003352)	2.99059448
27	lateral sprouting from an epithelium (GO:0060601)	2.98167335
28	pseudouridine synthesis (GO:0001522)	2.95029420
29	negative regulation of astrocyte differentiation (GO:0048712)	2.93813945
30	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90915184
31	parturition (GO:0007567)	2.90561154
32	startle response (GO:0001964)	2.90176547
33	presynaptic membrane assembly (GO:0097105)	2.88614030
34	DNA deamination (GO:0045006)	2.88359677
35	platelet dense granule organization (GO:0060155)	2.83235019
36	ATP synthesis coupled proton transport (GO:0015986)	2.77738973
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.77738973
38	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.77467968
39	synaptic transmission, cholinergic (GO:0007271)	2.76458477
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75356524
41	rhodopsin mediated signaling pathway (GO:0016056)	2.73510253
42	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.72045994
43	reflex (GO:0060004)	2.71986751
44	regulation of neurotransmitter uptake (GO:0051580)	2.71907236
45	nucleobase catabolic process (GO:0046113)	2.69804685
46	positive regulation of meiosis (GO:0045836)	2.68204083
47	kynurenine metabolic process (GO:0070189)	2.65424020
48	head development (GO:0060322)	2.65207665
49	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.63716468
50	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.63716468
51	primary amino compound metabolic process (GO:1901160)	2.63130822
52	regulation of male gonad development (GO:2000018)	2.61658730
53	presynaptic membrane organization (GO:0097090)	2.61255799
54	piRNA metabolic process (GO:0034587)	2.59714542
55	DNA methylation involved in gamete generation (GO:0043046)	2.59482911
56	membrane depolarization during action potential (GO:0086010)	2.56888676
57	serotonin metabolic process (GO:0042428)	2.56876195
58	indole-containing compound metabolic process (GO:0042430)	2.55529717
59	positive regulation of fatty acid transport (GO:2000193)	2.55175506
60	regulation of posttranscriptional gene silencing (GO:0060147)	2.54267894
61	regulation of gene silencing by miRNA (GO:0060964)	2.54267894
62	regulation of gene silencing by RNA (GO:0060966)	2.54267894
63	transmission of nerve impulse (GO:0019226)	2.53806075
64	neuronal action potential propagation (GO:0019227)	2.52735737
65	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.51819988
66	positive regulation of meiotic cell cycle (GO:0051446)	2.49573138
67	ovulation cycle (GO:0042698)	2.46730491
68	peristalsis (GO:0030432)	2.45179904
69	ubiquinone biosynthetic process (GO:0006744)	2.44759151
70	retinal ganglion cell axon guidance (GO:0031290)	2.42874272
71	protein localization to cilium (GO:0061512)	2.42682424
72	negative regulation of appetite (GO:0032099)	2.42548674
73	negative regulation of response to food (GO:0032096)	2.42548674
74	male meiosis I (GO:0007141)	2.42303783
75	rRNA catabolic process (GO:0016075)	2.42090555
76	epithelial cilium movement (GO:0003351)	2.42004074
77	auditory behavior (GO:0031223)	2.40373842
78	regulation of microtubule-based movement (GO:0060632)	2.39923555
79	behavioral response to ethanol (GO:0048149)	2.39675042
80	mechanosensory behavior (GO:0007638)	2.39475766
81	chaperone-mediated protein transport (GO:0072321)	2.36216007
82	positive regulation of cAMP-mediated signaling (GO:0043950)	2.35905599
83	fucose catabolic process (GO:0019317)	2.33349409
84	L-fucose metabolic process (GO:0042354)	2.33349409
85	L-fucose catabolic process (GO:0042355)	2.33349409
86	adaptation of signaling pathway (GO:0023058)	2.33147264
87	regulation of glomerulus development (GO:0090192)	2.32821917
88	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.31903186
89	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.31903186
90	regulation of collateral sprouting (GO:0048670)	2.31898283
91	cellular response to ATP (GO:0071318)	2.31612259
92	indole-containing compound catabolic process (GO:0042436)	2.31502622
93	indolalkylamine catabolic process (GO:0046218)	2.31502622
94	tryptophan catabolic process (GO:0006569)	2.31502622
95	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.31500096
96	embryonic epithelial tube formation (GO:0001838)	2.31100013
97	resolution of meiotic recombination intermediates (GO:0000712)	2.30574515
98	spinal cord motor neuron differentiation (GO:0021522)	2.30465385
99	limb bud formation (GO:0060174)	2.29928506
100	cellular anion homeostasis (GO:0030002)	2.29477476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.12285770
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.12653499
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.90556935
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.79624076
5	VDR_22108803_ChIP-Seq_LS180_Human	2.68061142
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.67521830
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55767521
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46408816
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42547425
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27553487
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20579832
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17744147
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.12098013
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.07582571
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.05593170
16	FUS_26573619_Chip-Seq_HEK293_Human	2.03349681
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99217456
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99037608
19	EWS_26573619_Chip-Seq_HEK293_Human	1.96591489
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90921627
21	P300_19829295_ChIP-Seq_ESCs_Human	1.90745826
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.85813689
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78350034
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.74585940
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74263819
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.73586179
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69539415
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68507473
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67319116
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65741686
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.58841457
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56758877
33	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.54124847
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50766559
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50675864
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50208257
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.49685260
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.45367329
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45116703
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43751709
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41136414
42	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.38601991
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38507348
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37565199
45	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.37073290
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.36736737
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.36610968
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34483435
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34483435
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33462630
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.33126558
52	STAT3_23295773_ChIP-Seq_U87_Human	1.33060606
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32355114
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31462865
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.31386145
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27050431
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26868054
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.26868054
59	TCF4_23295773_ChIP-Seq_U87_Human	1.26600342
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.25651551
61	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.24486883
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24441901
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24138399
64	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.23572154
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23039660
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22171486
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21505616
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20996049
69	AR_25329375_ChIP-Seq_VCAP_Human	1.19803825
70	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17620932
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17602354
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16191052
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.14996396
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14978642
75	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.14116364
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13802718
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.12935698
78	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12822497
79	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12822497
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11233614
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11233614
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10997247
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10437978
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09775828
85	NCOR_22424771_ChIP-Seq_293T_Human	1.08871579
86	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.08757900
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.07493157
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07355634
89	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.05876137
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04938286
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03822728
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02880861
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02826780
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02770230
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02423880
96	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02212573
97	RXR_22108803_ChIP-Seq_LS180_Human	1.01967805
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00969839
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99902856
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99902856

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.72388632
2	MP0000569_abnormal_digit_pigmentation	2.65200356
3	MP0003646_muscle_fatigue	2.61955393
4	MP0001485_abnormal_pinna_reflex	2.47084219
5	MP0000566_synostosis	2.32232829
6	MP0003122_maternal_imprinting	2.27457973
7	MP0004142_abnormal_muscle_tone	2.18266631
8	MP0001968_abnormal_touch/_nociception	2.10288433
9	MP0003136_yellow_coat_color	2.06530562
10	MP0005551_abnormal_eye_electrophysiolog	2.05359102
11	MP0008877_abnormal_DNA_methylation	2.05016328
12	MP0004145_abnormal_muscle_electrophysio	2.04136067
13	MP0002102_abnormal_ear_morphology	2.02304158
14	MP0008872_abnormal_physiological_respon	1.99776030
15	MP0006276_abnormal_autonomic_nervous	1.94195324
16	MP0002160_abnormal_reproductive_system	1.91935383
17	MP0004742_abnormal_vestibular_system	1.89845033
18	MP0000631_abnormal_neuroendocrine_gland	1.88242219
19	MP0009046_muscle_twitch	1.85007074
20	MP0004885_abnormal_endolymph	1.83395457
21	MP0002837_dystrophic_cardiac_calcinosis	1.80759743
22	MP0002735_abnormal_chemical_nociception	1.74555155
23	MP0005646_abnormal_pituitary_gland	1.71219940
24	MP0002272_abnormal_nervous_system	1.69042374
25	MP0009745_abnormal_behavioral_response	1.67259817
26	MP0002876_abnormal_thyroid_physiology	1.63012240
27	MP0002736_abnormal_nociception_after	1.62678123
28	MP0000049_abnormal_middle_ear	1.62537732
29	MP0008789_abnormal_olfactory_epithelium	1.62127326
30	MP0005084_abnormal_gallbladder_morpholo	1.61251938
31	MP0002938_white_spotting	1.60811371
32	MP0003011_delayed_dark_adaptation	1.59148277
33	MP0009379_abnormal_foot_pigmentation	1.57991547
34	MP0002733_abnormal_thermal_nociception	1.57633645
35	MP0003787_abnormal_imprinting	1.47341293
36	MP0004130_abnormal_muscle_cell	1.46624666
37	MP0003121_genomic_imprinting	1.46257728
38	MP0002638_abnormal_pupillary_reflex	1.45463922
39	MP0005389_reproductive_system_phenotype	1.44895509
40	MP0003880_abnormal_central_pattern	1.42319036
41	MP0001440_abnormal_grooming_behavior	1.41953198
42	MP0005174_abnormal_tail_pigmentation	1.40937717
43	MP0001986_abnormal_taste_sensitivity	1.40820118
44	MP0001970_abnormal_pain_threshold	1.40706396
45	MP0002572_abnormal_emotion/affect_behav	1.40457696
46	MP0003567_abnormal_fetal_cardiomyocyte	1.37993890
47	MP0002653_abnormal_ependyma_morphology	1.37252808
48	MP0008875_abnormal_xenobiotic_pharmacok	1.37212668
49	MP0003195_calcinosis	1.35690272
50	MP0004133_heterotaxia	1.34400625
51	MP0006072_abnormal_retinal_apoptosis	1.34372194
52	MP0001984_abnormal_olfaction	1.34033343
53	MP0001486_abnormal_startle_reflex	1.33675449
54	MP0001529_abnormal_vocalization	1.33570995
55	MP0002557_abnormal_social/conspecific_i	1.33290986
56	MP0002734_abnormal_mechanical_nocicepti	1.32996147
57	MP0003878_abnormal_ear_physiology	1.30032415
58	MP0005377_hearing/vestibular/ear_phenot	1.30032415
59	MP0002928_abnormal_bile_duct	1.29996752
60	MP0003635_abnormal_synaptic_transmissio	1.27969262
61	MP0000026_abnormal_inner_ear	1.26847344
62	MP0000778_abnormal_nervous_system	1.24434932
63	MP0001963_abnormal_hearing_physiology	1.23296926
64	MP0003119_abnormal_digestive_system	1.20355995
65	MP0002067_abnormal_sensory_capabilities	1.19902567
66	MP0002063_abnormal_learning/memory/cond	1.16793012
67	MP0002064_seizures	1.16628066
68	MP0000383_abnormal_hair_follicle	1.14352885
69	MP0003937_abnormal_limbs/digits/tail_de	1.13393340
70	MP0000427_abnormal_hair_cycle	1.12679792
71	MP0002138_abnormal_hepatobiliary_system	1.12025799
72	MP0005253_abnormal_eye_physiology	1.09852214
73	MP0005670_abnormal_white_adipose	1.08288532
74	MP0002277_abnormal_respiratory_mucosa	1.07559232
75	MP0002184_abnormal_innervation	1.07328717
76	MP0005195_abnormal_posterior_eye	1.06088162
77	MP0000537_abnormal_urethra_morphology	1.05344966
78	MP0002752_abnormal_somatic_nervous	1.04394606
79	MP0004859_abnormal_synaptic_plasticity	0.99543029
80	MP0002095_abnormal_skin_pigmentation	0.98592636
81	MP0005386_behavior/neurological_phenoty	0.97855185
82	MP0004924_abnormal_behavior	0.97855185
83	MP0001905_abnormal_dopamine_level	0.97714133
84	MP0003890_abnormal_embryonic-extraembry	0.97709153
85	MP0001293_anophthalmia	0.96650068
86	MP0005423_abnormal_somatic_nervous	0.95204317
87	MP0001348_abnormal_lacrimal_gland	0.94421173
88	MP0005645_abnormal_hypothalamus_physiol	0.93622254
89	MP0003938_abnormal_ear_development	0.93061114
90	MP0000955_abnormal_spinal_cord	0.92175279
91	MP0005499_abnormal_olfactory_system	0.90576743
92	MP0005394_taste/olfaction_phenotype	0.90576743
93	MP0000230_abnormal_systemic_arterial	0.90228978
94	MP0005410_abnormal_fertilization	0.87444078
95	MP0003942_abnormal_urinary_system	0.85943951
96	MP0002882_abnormal_neuron_morphology	0.82327249
97	MP0003879_abnormal_hair_cell	0.81201501
98	MP0002229_neurodegeneration	0.79730289
99	MP0010030_abnormal_orbit_morphology	0.78353823
100	MP0000372_irregular_coat_pigmentation	0.77179898

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.52768083
2	True hermaphroditism (HP:0010459)	4.08081194
3	Pancreatic fibrosis (HP:0100732)	3.80067403
4	Molar tooth sign on MRI (HP:0002419)	3.71059262
5	Abnormality of midbrain morphology (HP:0002418)	3.71059262
6	Pancreatic cysts (HP:0001737)	3.59203166
7	Nephronophthisis (HP:0000090)	3.51678791
8	Reticulocytopenia (HP:0001896)	2.93780167
9	Abnormality of the renal medulla (HP:0100957)	2.93379521
10	Type II lissencephaly (HP:0007260)	2.90235570
11	Abnormal rod and cone electroretinograms (HP:0008323)	2.90080787
12	Pendular nystagmus (HP:0012043)	2.86463811
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79091169
14	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.70664542
15	Abnormality of the renal collecting system (HP:0004742)	2.68793081
16	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.67865729
17	Abolished electroretinogram (ERG) (HP:0000550)	2.61367186
18	Genetic anticipation (HP:0003743)	2.58395151
19	Progressive cerebellar ataxia (HP:0002073)	2.54416524
20	Congenital, generalized hypertrichosis (HP:0004540)	2.53998657
21	Asplenia (HP:0001746)	2.53198208
22	Ectopic kidney (HP:0000086)	2.50954250
23	Stenosis of the external auditory canal (HP:0000402)	2.47316198
24	Abnormality of the labia minora (HP:0012880)	2.45991859
25	Septo-optic dysplasia (HP:0100842)	2.45187603
26	Cystic liver disease (HP:0006706)	2.44600278
27	Medial flaring of the eyebrow (HP:0010747)	2.44010359
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.39280141
29	Attenuation of retinal blood vessels (HP:0007843)	2.38096511
30	Hyperventilation (HP:0002883)	2.37911860
31	Optic nerve hypoplasia (HP:0000609)	2.36496933
32	Male pseudohermaphroditism (HP:0000037)	2.32689641
33	Increased corneal curvature (HP:0100692)	2.32302533
34	Keratoconus (HP:0000563)	2.32302533
35	Sclerocornea (HP:0000647)	2.31284368
36	Abnormality of the middle phalanges of the toes (HP:0010183)	2.27996012
37	Gait imbalance (HP:0002141)	2.24210448
38	Bile duct proliferation (HP:0001408)	2.23467654
39	Abnormal biliary tract physiology (HP:0012439)	2.23467654
40	Colon cancer (HP:0003003)	2.20973362
41	Duplicated collecting system (HP:0000081)	2.20262465
42	Absent thumb (HP:0009777)	2.16545286
43	Short hallux (HP:0010109)	2.14999367
44	Abnormality of the renal cortex (HP:0011035)	2.14529866
45	Acute necrotizing encephalopathy (HP:0006965)	2.13281046
46	Furrowed tongue (HP:0000221)	2.12863817
47	Vaginal atresia (HP:0000148)	2.12853231
48	Agitation (HP:0000713)	2.12852539
49	Genital tract atresia (HP:0001827)	2.10324838
50	Congenital sensorineural hearing impairment (HP:0008527)	2.10230467
51	Anencephaly (HP:0002323)	2.09842781
52	Hemiparesis (HP:0001269)	2.09263224
53	Congenital primary aphakia (HP:0007707)	2.08156999
54	Febrile seizures (HP:0002373)	2.07641953
55	Abnormality of DNA repair (HP:0003254)	2.06470997
56	Abnormal number of incisors (HP:0011064)	2.06011570
57	Optic nerve coloboma (HP:0000588)	2.05140922
58	Decreased central vision (HP:0007663)	2.04068993
59	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.99903873
60	Broad-based gait (HP:0002136)	1.98932823
61	Nephrogenic diabetes insipidus (HP:0009806)	1.96133857
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95270348
63	Lissencephaly (HP:0001339)	1.93675902
64	Osteomalacia (HP:0002749)	1.91645279
65	Chronic hepatic failure (HP:0100626)	1.88824655
66	Confusion (HP:0001289)	1.86444521
67	Abnormality of cells of the erythroid lineage (HP:0012130)	1.85912936
68	Abnormal number of erythroid precursors (HP:0012131)	1.85614923
69	Tubular atrophy (HP:0000092)	1.85424286
70	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.84971460
71	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83810052
72	Progressive macrocephaly (HP:0004481)	1.83318686
73	Acute encephalopathy (HP:0006846)	1.81115196
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.80157199
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78922089
76	2-3 toe syndactyly (HP:0004691)	1.78885938
77	Rib fusion (HP:0000902)	1.78820212
78	Mitochondrial inheritance (HP:0001427)	1.78627359
79	Optic disc pallor (HP:0000543)	1.77839581
80	Polyphagia (HP:0002591)	1.76373156
81	Chorioretinal atrophy (HP:0000533)	1.74649744
82	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73832748
83	Absent/shortened dynein arms (HP:0200106)	1.73832748
84	Congenital hepatic fibrosis (HP:0002612)	1.73459150
85	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.71882623
86	Limb dystonia (HP:0002451)	1.71616401
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71488593
88	Abnormality of alanine metabolism (HP:0010916)	1.71488593
89	Hyperalaninemia (HP:0003348)	1.71488593
90	Horseshoe kidney (HP:0000085)	1.71263736
91	Hyperglycinemia (HP:0002154)	1.70596306
92	Inability to walk (HP:0002540)	1.70229038
93	Gaze-evoked nystagmus (HP:0000640)	1.70070805
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69915708
95	Methylmalonic aciduria (HP:0012120)	1.69672843
96	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.68863000
97	Postaxial foot polydactyly (HP:0001830)	1.67759072
98	Hypoplasia of the pons (HP:0012110)	1.67548338
99	Preaxial hand polydactyly (HP:0001177)	1.66296509
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.65766930

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.67415530
2	ADRBK2	3.98138474
3	GRK1	3.70876052
4	CASK	2.87536834
5	WNK3	2.79447657
6	NUAK1	2.78600668
7	WNK4	2.65119165
8	BMPR1B	2.58593004
9	PINK1	2.34424818
10	INSRR	2.28106409
11	PNCK	1.98507296
12	ZAK	1.97788417
13	DYRK2	1.83313597
14	FGFR2	1.80799865
15	NTRK3	1.74920233
16	MAP3K4	1.62301465
17	MUSK	1.61067507
18	STK39	1.59563208
19	MAPK13	1.55370267
20	ACVR1B	1.43392081
21	TNIK	1.32124800
22	MARK1	1.31845416
23	ADRBK1	1.31418416
24	NTRK2	1.21531200
25	TLK1	1.21515692
26	PLK2	1.19229895
27	TAF1	1.17712073
28	PRKCG	1.16560706
29	PAK3	1.14708837
30	VRK1	1.12810508
31	MKNK2	1.12272177
32	TIE1	1.08311139
33	EPHB2	1.04829469
34	MAP2K7	1.02726704
35	DAPK2	0.98982269
36	MAP4K2	0.98010182
37	NLK	0.96720748
38	OXSR1	0.94631650
39	SIK2	0.93969786
40	LATS1	0.92317466
41	VRK2	0.91411034
42	CAMKK1	0.90112426
43	DYRK1A	0.85248462
44	PRKCE	0.83573862
45	WEE1	0.72404639
46	PTK2B	0.71874897
47	CAMK2A	0.70595248
48	CSNK1G2	0.69435855
49	CAMKK2	0.69166002
50	TXK	0.69009018
51	TAOK3	0.68758850
52	DYRK1B	0.66777722
53	PRKACA	0.65735709
54	CSNK1G1	0.65447190
55	RPS6KA6	0.65261706
56	GRK5	0.65221853
57	STK11	0.64429145
58	CAMK1	0.64422052
59	TGFBR1	0.61542415
60	MAPK15	0.61508084
61	MAP3K9	0.60635085
62	PRKCQ	0.59732279
63	PRKCH	0.58281669
64	PDK2	0.57353122
65	CDK19	0.55581030
66	CSNK1A1	0.54195982
67	PLK1	0.53131023
68	STK38L	0.52978787
69	NME1	0.52747324
70	TYRO3	0.52585010
71	PIK3CA	0.52023529
72	DYRK3	0.50851302
73	PLK3	0.50662853
74	GRK7	0.49511671
75	CDC7	0.48577300
76	PKN1	0.48432351
77	SGK1	0.45859889
78	CSNK1G3	0.44734214
79	IRAK1	0.43824975
80	ERBB2	0.43272234
81	CAMK1G	0.42033652
82	CSNK1A1L	0.40725621
83	NEK2	0.40489636
84	PRKCZ	0.39969157
85	IKBKB	0.38765107
86	PRKCA	0.37889716
87	RPS6KA5	0.36655679
88	MKNK1	0.36468265
89	CAMK1D	0.35763999
90	BCKDK	0.35719467
91	PRKG1	0.35641130
92	ABL2	0.35422273
93	PASK	0.34700634
94	STK3	0.34571685
95	SGK494	0.34075438
96	SGK223	0.34075438
97	SGK2	0.33709997
98	MINK1	0.29916876
99	CDK5	0.29829989
100	WNK1	0.29168691

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.12630976
2	Ribosome_Homo sapiens_hsa03010	2.62876559
3	Nicotine addiction_Homo sapiens_hsa05033	2.57787519
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56113446
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51421917
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38933508
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.10349429
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.07047714
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.04397563
10	Parkinsons disease_Homo sapiens_hsa05012	2.01916130
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99726960
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98436368
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94865328
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85051968
15	Morphine addiction_Homo sapiens_hsa05032	1.77715950
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.76606246
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.73442477
18	Taste transduction_Homo sapiens_hsa04742	1.67007481
19	Olfactory transduction_Homo sapiens_hsa04740	1.64626772
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62450905
21	Alzheimers disease_Homo sapiens_hsa05010	1.57286718
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56173521
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54632275
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52083148
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51453398
26	Huntingtons disease_Homo sapiens_hsa05016	1.48936659
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.43864620
28	Basal transcription factors_Homo sapiens_hsa03022	1.43359300
29	Butanoate metabolism_Homo sapiens_hsa00650	1.40478349
30	Retinol metabolism_Homo sapiens_hsa00830	1.39684177
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.38283802
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.35387779
33	Caffeine metabolism_Homo sapiens_hsa00232	1.32508319
34	RNA degradation_Homo sapiens_hsa03018	1.32401784
35	Circadian entrainment_Homo sapiens_hsa04713	1.31441052
36	RNA polymerase_Homo sapiens_hsa03020	1.29558467
37	Serotonergic synapse_Homo sapiens_hsa04726	1.28897496
38	Peroxisome_Homo sapiens_hsa04146	1.28450445
39	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.27569857
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.26223567
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25200997
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.23126665
43	GABAergic synapse_Homo sapiens_hsa04727	1.21904899
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19706873
45	Homologous recombination_Homo sapiens_hsa03440	1.19674265
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18818645
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18694525
48	Basal cell carcinoma_Homo sapiens_hsa05217	1.16111536
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11643638
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10561060
51	Sulfur metabolism_Homo sapiens_hsa00920	1.05067951
52	Fat digestion and absorption_Homo sapiens_hsa04975	1.04863479
53	Insulin secretion_Homo sapiens_hsa04911	1.02656867
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02648581
55	Protein export_Homo sapiens_hsa03060	1.02057434
56	Glycerolipid metabolism_Homo sapiens_hsa00561	1.00895622
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92853444
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91431822
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87412064
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85779706
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.85077604
62	Histidine metabolism_Homo sapiens_hsa00340	0.81815341
63	Asthma_Homo sapiens_hsa05310	0.76751767
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76404317
65	Cholinergic synapse_Homo sapiens_hsa04725	0.75180704
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.74642615
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69904594
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68541374
69	Sulfur relay system_Homo sapiens_hsa04122	0.64551054
70	Long-term depression_Homo sapiens_hsa04730	0.63850404
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.62182004
72	ABC transporters_Homo sapiens_hsa02010	0.62023430
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59014762
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55263123
75	Propanoate metabolism_Homo sapiens_hsa00640	0.54625165
76	One carbon pool by folate_Homo sapiens_hsa00670	0.53043087
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52547009
78	Metabolic pathways_Homo sapiens_hsa01100	0.52368590
79	Salivary secretion_Homo sapiens_hsa04970	0.51371894
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50483917
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48451503
82	Axon guidance_Homo sapiens_hsa04360	0.48244595
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46687901
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45938737
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45238989
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43157435
87	Purine metabolism_Homo sapiens_hsa00230	0.41907331
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41590992
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40789514
90	Cocaine addiction_Homo sapiens_hsa05030	0.38627987
91	Regulation of autophagy_Homo sapiens_hsa04140	0.37860210
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37846376
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.36986586
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.36420842
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35548096
96	Gastric acid secretion_Homo sapiens_hsa04971	0.34796561
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34514121
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34124393
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.33976183
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.32898655

TPM4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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