TPMTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)6.45855745
2cytidine catabolic process (GO:0006216)6.45855745
3cytidine deamination (GO:0009972)6.45855745
4DNA deamination (GO:0045006)6.25518539
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.52643554
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.46063943
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93438562
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62487053
9ATP synthesis coupled proton transport (GO:0015986)4.56636137
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56636137
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.22749247
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.22749247
13proteasome assembly (GO:0043248)4.06631481
14respiratory electron transport chain (GO:0022904)3.79786265
15protein neddylation (GO:0045116)3.78802775
16electron transport chain (GO:0022900)3.74509018
17regulation of cellular amino acid metabolic process (GO:0006521)3.54200860
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.45700975
19regulation of mitotic spindle checkpoint (GO:1903504)3.45700975
20negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45000772
21protein complex biogenesis (GO:0070271)3.41436438
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38864932
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.36753229
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31006887
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28641969
26respiratory chain complex IV assembly (GO:0008535)3.27929747
27regulation of regulatory T cell differentiation (GO:0045589)3.27204653
28regulation of T cell receptor signaling pathway (GO:0050856)3.25380763
29positive regulation of defense response to virus by host (GO:0002230)3.24049831
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23407242
31cullin deneddylation (GO:0010388)3.22259177
32regulation of memory T cell differentiation (GO:0043380)3.21815447
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21450257
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19232953
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.18076384
36termination of RNA polymerase III transcription (GO:0006386)3.18076384
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17418175
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17418175
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16055275
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16055275
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16055275
42cell wall macromolecule catabolic process (GO:0016998)3.15392787
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14013931
44mitochondrial respiratory chain complex assembly (GO:0033108)3.12086321
45actin nucleation (GO:0045010)3.10844839
46negative regulation of ligase activity (GO:0051352)3.03381700
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03381700
48cytochrome complex assembly (GO:0017004)3.03235406
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.00952523
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00952523
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00395661
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.00395661
53NADH dehydrogenase complex assembly (GO:0010257)3.00395661
54protein deneddylation (GO:0000338)2.98928741
55signal transduction involved in cell cycle checkpoint (GO:0072395)2.98179609
56pseudouridine synthesis (GO:0001522)2.97722752
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97558475
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95251723
59antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.94860827
60pyrimidine nucleoside catabolic process (GO:0046135)2.94713137
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.94694266
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94470209
63aldehyde catabolic process (GO:0046185)2.94064024
64negative regulation of heart rate (GO:0010459)2.91916322
65positive regulation of monocyte chemotaxis (GO:0090026)2.88873734
66response to testosterone (GO:0033574)2.88445807
67hydrogen ion transmembrane transport (GO:1902600)2.85770853
68GPI anchor biosynthetic process (GO:0006506)2.85326536
69DNA demethylation (GO:0080111)2.84527076
70regulation of cilium movement (GO:0003352)2.83605603
71GPI anchor metabolic process (GO:0006505)2.79142544
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75849569
73proton transport (GO:0015992)2.74582842
74hydrogen transport (GO:0006818)2.74080148
75rRNA catabolic process (GO:0016075)2.71261735
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70589338
77oxidative phosphorylation (GO:0006119)2.70262006
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67314940
79signal peptide processing (GO:0006465)2.66250615
80peptidyl-histidine modification (GO:0018202)2.65082458
81eosinophil chemotaxis (GO:0048245)2.64731455
82negative regulation of mast cell activation (GO:0033004)2.64572324
83positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64037694
84negative regulation of T cell receptor signaling pathway (GO:0050860)2.63691016
85cell wall macromolecule metabolic process (GO:0044036)2.63546827
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61145608
87preassembly of GPI anchor in ER membrane (GO:0016254)2.60887385
88platelet dense granule organization (GO:0060155)2.60442565
89positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.60111750
90mannosylation (GO:0097502)2.60035053
91response to pheromone (GO:0019236)2.59734110
92regulation of cellular respiration (GO:0043457)2.56413257
93synapsis (GO:0007129)2.54568620
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53766594
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53157947
96ATP biosynthetic process (GO:0006754)2.53048351
97T cell costimulation (GO:0031295)2.53029332
98S-adenosylmethionine metabolic process (GO:0046500)2.52677986
99regulation of cellular amine metabolic process (GO:0033238)2.52120881
100regulation of alpha-beta T cell proliferation (GO:0046640)2.50789102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.17384103
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.07986188
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.99780103
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83153105
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.42598357
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75469862
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72488342
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71308101
9VDR_22108803_ChIP-Seq_LS180_Human2.70047359
10VDR_23849224_ChIP-Seq_CD4+_Human2.68063976
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.62917888
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46361430
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45371100
14ELK1_19687146_ChIP-ChIP_HELA_Human2.42058163
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39812281
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37685578
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.27305025
18FOXP3_21729870_ChIP-Seq_TREG_Human2.26166114
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.25348475
20ZNF274_21170338_ChIP-Seq_K562_Hela2.24278845
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11804322
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.08346160
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04765652
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87960280
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84228085
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75748022
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73079969
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72536608
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72191457
30IGF1R_20145208_ChIP-Seq_DFB_Human1.64223024
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63165995
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63094802
33IRF1_19129219_ChIP-ChIP_H3396_Human1.53513923
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52353878
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.51242069
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51235535
37MYC_18940864_ChIP-ChIP_HL60_Human1.50470447
38TP53_22573176_ChIP-Seq_HFKS_Human1.49821094
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44164536
40EWS_26573619_Chip-Seq_HEK293_Human1.43192025
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.41474053
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41474053
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41140022
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36141288
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33359805
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32880980
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32092237
48AR_20517297_ChIP-Seq_VCAP_Human1.31296410
49GATA3_26560356_Chip-Seq_TH2_Human1.27954291
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27385791
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26423963
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25694686
53NANOG_19829295_ChIP-Seq_ESCs_Human1.25609447
54SOX2_19829295_ChIP-Seq_ESCs_Human1.25609447
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25362260
56FUS_26573619_Chip-Seq_HEK293_Human1.21906668
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.21828082
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20142480
59P300_19829295_ChIP-Seq_ESCs_Human1.19906806
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19514286
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18753218
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16945704
63CBP_20019798_ChIP-Seq_JUKART_Human1.16945704
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12340350
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11638806
66DCP1A_22483619_ChIP-Seq_HELA_Human1.11487061
67MYB_26560356_Chip-Seq_TH2_Human1.10866313
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.09508326
69SPI1_23547873_ChIP-Seq_NB4_Human1.09359966
70HTT_18923047_ChIP-ChIP_STHdh_Human1.08698997
71TAF15_26573619_Chip-Seq_HEK293_Human1.08679872
72ERG_20517297_ChIP-Seq_VCAP_Human1.07248910
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07167369
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05981096
75GABP_19822575_ChIP-Seq_HepG2_Human1.05841643
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04404373
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.02307316
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02290950
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02283964
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.02213781
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01341185
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01009184
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00291991
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99910153
85NCOR_22424771_ChIP-Seq_293T_Human0.99717143
86BCAT_22108803_ChIP-Seq_LS180_Human0.98897526
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97729305
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97599184
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96206470
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94954119
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94823243
92TTF2_22483619_ChIP-Seq_HELA_Human0.94333036
93MYC_18555785_ChIP-Seq_MESCs_Mouse0.94260650
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94005144
95GATA3_26560356_Chip-Seq_TH1_Human0.93881750
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92543084
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92096335
98ER_23166858_ChIP-Seq_MCF-7_Human0.91442116
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91424019
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.90967257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis9.21708169
2MP0005671_abnormal_response_to3.80598135
3MP0001835_abnormal_antigen_presentation3.75113674
4MP0009785_altered_susceptibility_to2.32664895
5MP0002148_abnormal_hypersensitivity_rea2.18395995
6MP0001529_abnormal_vocalization2.14209288
7MP0003787_abnormal_imprinting2.11012266
8MP0002837_dystrophic_cardiac_calcinosis2.09852536
9MP0002102_abnormal_ear_morphology2.05885977
10MP0006072_abnormal_retinal_apoptosis2.03351661
11MP0003195_calcinosis2.02476561
12MP0000372_irregular_coat_pigmentation1.92090541
13MP0008877_abnormal_DNA_methylation1.79791442
14MP0003718_maternal_effect1.73518847
15MP0006036_abnormal_mitochondrial_physio1.68802289
16MP0001984_abnormal_olfaction1.67452120
17MP0003186_abnormal_redox_activity1.66566890
18MP0008875_abnormal_xenobiotic_pharmacok1.62841805
19MP0005253_abnormal_eye_physiology1.60643560
20MP0008058_abnormal_DNA_repair1.59739071
21MP0005075_abnormal_melanosome_morpholog1.57468030
22MP0005000_abnormal_immune_tolerance1.54430352
23MP0001800_abnormal_humoral_immune1.54074235
24MP0003866_abnormal_defecation1.49278004
25MP0002166_altered_tumor_susceptibility1.49157112
26MP0002452_abnormal_antigen_presenting1.46179100
27MP0002723_abnormal_immune_serum1.45430664
28MP0009764_decreased_sensitivity_to1.44368805
29MP0004147_increased_porphyrin_level1.40588013
30MP0005646_abnormal_pituitary_gland1.40411447
31MP0008789_abnormal_olfactory_epithelium1.39756107
32MP0001853_heart_inflammation1.38085237
33MP0005645_abnormal_hypothalamus_physiol1.36679907
34MP0002876_abnormal_thyroid_physiology1.36257985
35MP0003011_delayed_dark_adaptation1.35633979
36MP0003786_premature_aging1.34783166
37MP0006054_spinal_hemorrhage1.34189131
38MP0005551_abnormal_eye_electrophysiolog1.34155486
39MP0001986_abnormal_taste_sensitivity1.31588112
40MP0001819_abnormal_immune_cell1.31327794
41MP0009697_abnormal_copulation1.30399402
42MP0002420_abnormal_adaptive_immunity1.27759691
43MP0009765_abnormal_xenobiotic_induced1.27332749
44MP0008007_abnormal_cellular_replicative1.27229058
45MP0008872_abnormal_physiological_respon1.25658730
46MP0003880_abnormal_central_pattern1.23813650
47MP0002006_tumorigenesis1.22676452
48MP0010386_abnormal_urinary_bladder1.18685210
49MP0010155_abnormal_intestine_physiology1.17887566
50MP0005636_abnormal_mineral_homeostasis1.15962798
51MP0001764_abnormal_homeostasis1.13371489
52MP0005332_abnormal_amino_acid1.13357176
53MP0006035_abnormal_mitochondrial_morpho1.11769698
54MP0009333_abnormal_splenocyte_physiolog1.11346191
55MP0001845_abnormal_inflammatory_respons1.10776887
56MP0001968_abnormal_touch/_nociception1.09906501
57MP0006082_CNS_inflammation1.09183969
58MP0005025_abnormal_response_to1.05230068
59MP0002139_abnormal_hepatobiliary_system1.04841991
60MP0004145_abnormal_muscle_electrophysio1.02743867
61MP0001905_abnormal_dopamine_level1.00150938
62MP0003252_abnormal_bile_duct0.95315876
63MP0003724_increased_susceptibility_to0.94955380
64MP0005266_abnormal_metabolism0.94000657
65MP0002736_abnormal_nociception_after0.91457084
66MP0008469_abnormal_protein_level0.90079952
67MP0004142_abnormal_muscle_tone0.88421954
68MP0002163_abnormal_gland_morphology0.88302164
69MP0008873_increased_physiological_sensi0.87121279
70MP0002090_abnormal_vision0.86604965
71MP0003172_abnormal_lysosome_physiology0.86604329
72MP0002693_abnormal_pancreas_physiology0.86599610
73MP0002398_abnormal_bone_marrow0.85223625
74MP0000716_abnormal_immune_system0.84614856
75MP0005499_abnormal_olfactory_system0.84472165
76MP0005394_taste/olfaction_phenotype0.84472165
77MP0009745_abnormal_behavioral_response0.84456745
78MP0002419_abnormal_innate_immunity0.83998100
79MP0001790_abnormal_immune_system0.83718872
80MP0005387_immune_system_phenotype0.83718872
81MP0005410_abnormal_fertilization0.83670020
82MP0001873_stomach_inflammation0.83649895
83MP0005085_abnormal_gallbladder_physiolo0.83100438
84MP0009763_increased_sensitivity_to0.82391727
85MP0002822_catalepsy0.79538305
86MP0001542_abnormal_bone_strength0.78388887
87MP0001919_abnormal_reproductive_system0.77988659
88MP0000689_abnormal_spleen_morphology0.74592747
89MP0009379_abnormal_foot_pigmentation0.73878332
90MP0000685_abnormal_immune_system0.73198175
91MP0003137_abnormal_impulse_conducting0.70265116
92MP0005379_endocrine/exocrine_gland_phen0.70091259
93MP0008995_early_reproductive_senescence0.69947251
94MP0002429_abnormal_blood_cell0.68815017
95MP0001666_abnormal_nutrient_absorption0.68782251
96MP0000427_abnormal_hair_cycle0.67727107
97MP0006276_abnormal_autonomic_nervous0.67226654
98MP0005389_reproductive_system_phenotype0.66491369
99MP0001486_abnormal_startle_reflex0.66422835
100MP0002019_abnormal_tumor_incidence0.66199935

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.22632176
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01310797
3Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01310797
4Mitochondrial inheritance (HP:0001427)3.91873483
5Aplastic anemia (HP:0001915)3.85445242
6Abnormal mitochondria in muscle tissue (HP:0008316)3.76123067
7Hepatocellular necrosis (HP:0001404)3.73857832
8Methylmalonic acidemia (HP:0002912)3.67376291
9Progressive macrocephaly (HP:0004481)3.65545849
10Increased CSF lactate (HP:0002490)3.63732004
11Congenital, generalized hypertrichosis (HP:0004540)3.59694266
12Acute encephalopathy (HP:0006846)3.43664168
13Hypothermia (HP:0002045)3.42601874
14Hypoproteinemia (HP:0003075)3.38502703
15Abnormality of the prostate (HP:0008775)3.34174384
16IgG deficiency (HP:0004315)3.29868542
17Hepatic necrosis (HP:0002605)3.22384672
183-Methylglutaconic aciduria (HP:0003535)3.20615562
19Increased hepatocellular lipid droplets (HP:0006565)3.11244384
20Lipid accumulation in hepatocytes (HP:0006561)3.07183423
21Elevated erythrocyte sedimentation rate (HP:0003565)3.06414346
22Renal Fanconi syndrome (HP:0001994)2.99538099
23Pancreatic cysts (HP:0001737)2.99040054
24Cerebral edema (HP:0002181)2.78732247
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75744375
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73789737
27Abolished electroretinogram (ERG) (HP:0000550)2.71563654
28Methylmalonic aciduria (HP:0012120)2.69089180
29Abnormality of alanine metabolism (HP:0010916)2.68461682
30Hyperalaninemia (HP:0003348)2.68461682
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68461682
32Increased intramyocellular lipid droplets (HP:0012240)2.68391158
33Increased serum lactate (HP:0002151)2.67455611
34Optic disc pallor (HP:0000543)2.59215287
35Severe combined immunodeficiency (HP:0004430)2.56019978
36Thyroiditis (HP:0100646)2.49638538
37Abnormality of vitamin B metabolism (HP:0004340)2.46286765
38T lymphocytopenia (HP:0005403)2.44085460
39Abnormality of T cell number (HP:0011839)2.43027621
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42048673
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.41801144
42Lactic acidosis (HP:0003128)2.40831781
43Chronic diarrhea (HP:0002028)2.40801781
44Exertional dyspnea (HP:0002875)2.37453951
45Renal cortical cysts (HP:0000803)2.36045870
46Increased muscle lipid content (HP:0009058)2.30551651
47Medial flaring of the eyebrow (HP:0010747)2.30022546
48Type I transferrin isoform profile (HP:0003642)2.25467043
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17218010
50Leukodystrophy (HP:0002415)2.16194732
51Hyperglycinuria (HP:0003108)2.16033266
52IgM deficiency (HP:0002850)2.15770767
53Abnormality of the renal cortex (HP:0011035)2.14321793
54Abnormality of eosinophils (HP:0001879)2.12230537
55Pancreatic fibrosis (HP:0100732)2.12130133
56Respiratory failure (HP:0002878)2.10123983
57Pancytopenia (HP:0001876)2.05183191
58Abnormality of T cells (HP:0002843)2.03413756
59Abnormality of methionine metabolism (HP:0010901)1.98780789
60Combined immunodeficiency (HP:0005387)1.97878362
61Alveolar cell carcinoma (HP:0006519)1.95777505
62Stomatitis (HP:0010280)1.95514458
63Abnormality of male internal genitalia (HP:0000022)1.95395098
64Abnormality of B cell number (HP:0010975)1.93753905
65Ureteral obstruction (HP:0006000)1.91781551
66Pulmonary fibrosis (HP:0002206)1.91732839
67Hemoptysis (HP:0002105)1.90772377
68Congenital primary aphakia (HP:0007707)1.89541189
69Hypoplasia of the fovea (HP:0007750)1.89329361
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.89329361
71Congenital stationary night blindness (HP:0007642)1.88880544
72Progressive microcephaly (HP:0000253)1.86813499
73B lymphocytopenia (HP:0010976)1.86264398
74Lethargy (HP:0001254)1.85732265
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83146841
76Nephrogenic diabetes insipidus (HP:0009806)1.82627180
77Parakeratosis (HP:0001036)1.82357006
78Eosinophilia (HP:0001880)1.80411486
79True hermaphroditism (HP:0010459)1.80335562
80Gait imbalance (HP:0002141)1.79610943
81Abnormality of serum amino acid levels (HP:0003112)1.79593466
82Dicarboxylic aciduria (HP:0003215)1.79361039
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79361039
84Petechiae (HP:0000967)1.78903456
85CNS demyelination (HP:0007305)1.76824444
86Insulin-resistant diabetes mellitus (HP:0000831)1.76614978
87Abnormality of the fovea (HP:0000493)1.76245695
88Facial diplegia (HP:0001349)1.75652258
89Exercise intolerance (HP:0003546)1.72459671
90Bile duct proliferation (HP:0001408)1.72456542
91Abnormal biliary tract physiology (HP:0012439)1.72456542
92Abnormality of the pleura (HP:0002103)1.72141024
93Spontaneous abortion (HP:0005268)1.71090723
94Amaurosis fugax (HP:0100576)1.70743755
95Nephronophthisis (HP:0000090)1.70339813
96Ureteral stenosis (HP:0000071)1.69607292
97Hypoglycemic seizures (HP:0002173)1.68834933
98Acute hepatic failure (HP:0006554)1.68582713
99Abnormal glycosylation (HP:0012345)1.67966703
100Abnormal protein N-linked glycosylation (HP:0012347)1.67966703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.98203351
2TXK3.71250655
3BMPR23.13493788
4MAP4K23.03344831
5TAOK32.82532074
6TLK12.78164790
7MAP3K122.50365937
8EIF2AK32.38241163
9FRK2.35311032
10KDR2.27674201
11NUAK11.83046099
12GRK11.79842813
13BCKDK1.79386668
14SRPK11.65326910
15MYLK1.63682480
16ADRBK21.63225004
17GRK71.58689492
18TEC1.57809561
19WNK31.46473139
20WNK41.43153576
21CDK191.39325856
22OXSR11.35029309
23CSNK1G21.30916368
24TSSK61.30350572
25VRK21.28474598
26ZAK1.24761281
27ITK1.23447136
28STK161.21946910
29CSNK1G31.17872422
30KIT1.15379415
31CSF1R1.11703075
32SCYL21.07032879
33TESK21.06754828
34NEK11.05107254
35SYK1.03601829
36IKBKB1.01065983
37RPS6KA41.00760910
38FES1.00599964
39BUB10.98411066
40ERBB30.97235347
41TESK10.94425306
42BMPR1B0.93985073
43DAPK20.89899773
44EIF2AK10.89892037
45INSRR0.88991630
46TRIM280.88682117
47CSNK1G10.88281212
48TGFBR20.87887416
49BTK0.87519322
50CSNK1A1L0.86593281
51STK38L0.85534244
52PRKCE0.83809548
53LYN0.83652261
54PLK20.82038380
55TIE10.82037439
56STK390.79715564
57DAPK10.78507009
58MAP4K10.76430511
59LIMK10.76169763
60PHKG20.73482494
61PHKG10.73482494
62MATK0.73271968
63VRK10.72990659
64LCK0.72547030
65PLK40.72013572
66PLK30.70021709
67CLK10.69884725
68RIPK40.68295748
69TNK20.65342032
70ATR0.64498032
71RPS6KA50.64471037
72FLT30.64366427
73PRKCQ0.63398610
74ILK0.62523668
75OBSCN0.53066062
76MAP2K60.52433734
77PRKCI0.51806448
78MAPKAPK50.51189356
79EIF2AK20.51110310
80PDK20.48008307
81DYRK20.47480600
82MAPK130.47414061
83AURKB0.47001609
84STK100.45915734
85GRK50.45246480
86BCR0.44566362
87ABL10.44202761
88EGFR0.43710928
89IGF1R0.42380035
90CSNK2A10.41292572
91PRKCA0.39250837
92DAPK30.37884360
93CSNK1A10.36941366
94HCK0.35560126
95CSNK2A20.34896824
96EPHA30.33944917
97PRKACA0.33930350
98CHEK20.33457856
99PLK10.33257582
100CAMK2A0.33210532

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.02787962
2Asthma_Homo sapiens_hsa053103.81880309
3Graft-versus-host disease_Homo sapiens_hsa053323.58188077
4Protein export_Homo sapiens_hsa030603.42736594
5Oxidative phosphorylation_Homo sapiens_hsa001903.39401863
6Allograft rejection_Homo sapiens_hsa053303.23197955
7Autoimmune thyroid disease_Homo sapiens_hsa053203.15508207
8Type I diabetes mellitus_Homo sapiens_hsa049403.08812436
9Antigen processing and presentation_Homo sapiens_hsa046122.80504792
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.74455228
11Parkinsons disease_Homo sapiens_hsa050122.73632732
12Primary immunodeficiency_Homo sapiens_hsa053402.10312268
13RNA polymerase_Homo sapiens_hsa030202.07349038
14Alzheimers disease_Homo sapiens_hsa050101.88288745
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87946869
16Rheumatoid arthritis_Homo sapiens_hsa053231.87027314
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78334370
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70057519
19Huntingtons disease_Homo sapiens_hsa050161.65324761
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59280493
21Ribosome_Homo sapiens_hsa030101.43832399
22Non-homologous end-joining_Homo sapiens_hsa034501.43178350
23Phototransduction_Homo sapiens_hsa047441.41853706
24Regulation of autophagy_Homo sapiens_hsa041401.36992805
25Viral myocarditis_Homo sapiens_hsa054161.35746195
26Staphylococcus aureus infection_Homo sapiens_hsa051501.33642964
27Homologous recombination_Homo sapiens_hsa034401.30398247
28Propanoate metabolism_Homo sapiens_hsa006401.28918887
29One carbon pool by folate_Homo sapiens_hsa006701.21546769
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20505575
31RNA degradation_Homo sapiens_hsa030181.15798328
32Cardiac muscle contraction_Homo sapiens_hsa042601.15653577
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.15318413
34Hematopoietic cell lineage_Homo sapiens_hsa046401.13948862
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12592536
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00717372
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92893373
38Spliceosome_Homo sapiens_hsa030400.90218483
39Leishmaniasis_Homo sapiens_hsa051400.85399371
40Linoleic acid metabolism_Homo sapiens_hsa005910.82301139
41Fanconi anemia pathway_Homo sapiens_hsa034600.81141076
42Pyrimidine metabolism_Homo sapiens_hsa002400.80837692
43Peroxisome_Homo sapiens_hsa041460.80583085
44Collecting duct acid secretion_Homo sapiens_hsa049660.78700556
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.77715797
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75407391
47Nitrogen metabolism_Homo sapiens_hsa009100.71191013
48Mismatch repair_Homo sapiens_hsa034300.70602031
49Purine metabolism_Homo sapiens_hsa002300.69315162
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68732314
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66528218
52Systemic lupus erythematosus_Homo sapiens_hsa053220.64220556
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.63406250
54Ether lipid metabolism_Homo sapiens_hsa005650.61058671
55Olfactory transduction_Homo sapiens_hsa047400.58366437
56DNA replication_Homo sapiens_hsa030300.58107730
57Tryptophan metabolism_Homo sapiens_hsa003800.57633271
58Sulfur metabolism_Homo sapiens_hsa009200.56584546
59Nucleotide excision repair_Homo sapiens_hsa034200.55453188
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55036677
61Arachidonic acid metabolism_Homo sapiens_hsa005900.54594368
62Chemical carcinogenesis_Homo sapiens_hsa052040.54259863
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.53660383
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52719600
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52608133
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52195284
67Legionellosis_Homo sapiens_hsa051340.52040621
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51231203
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51056008
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49976042
71Basal transcription factors_Homo sapiens_hsa030220.49607964
72Herpes simplex infection_Homo sapiens_hsa051680.49588377
73Epstein-Barr virus infection_Homo sapiens_hsa051690.49299487
74Caffeine metabolism_Homo sapiens_hsa002320.49249804
75Metabolic pathways_Homo sapiens_hsa011000.48078983
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46472252
77RNA transport_Homo sapiens_hsa030130.43359822
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42012110
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40693382
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38187966
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37753987
82Retinol metabolism_Homo sapiens_hsa008300.37616295
83Phagosome_Homo sapiens_hsa041450.37173728
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36689762
85Fatty acid elongation_Homo sapiens_hsa000620.36391943
86Butanoate metabolism_Homo sapiens_hsa006500.35652325
87Glutathione metabolism_Homo sapiens_hsa004800.33755500
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.33609226
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33464819
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31865547
91Fat digestion and absorption_Homo sapiens_hsa049750.30879488
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30364760
93Taste transduction_Homo sapiens_hsa047420.29310606
94Influenza A_Homo sapiens_hsa051640.28291522
95Salmonella infection_Homo sapiens_hsa051320.26165659
96Tuberculosis_Homo sapiens_hsa051520.26027516
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.26007650
98Toxoplasmosis_Homo sapiens_hsa051450.22898543
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22721251
100Pyruvate metabolism_Homo sapiens_hsa006200.22282322

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