TPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lead ion (GO:0010288)9.50711401
2sulfate transmembrane transport (GO:1902358)9.17021668
3regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)7.75711079
4positive regulation of glycogen biosynthetic process (GO:0045725)7.73997014
5sulfate transport (GO:0008272)7.60679539
6regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033397.59950603
7nephron tubule formation (GO:0072079)7.24983703
8phosphorelay signal transduction system (GO:0000160)7.23805739
9negative regulation of microtubule polymerization (GO:0031115)7.09866882
10regulation of apoptotic process involved in morphogenesis (GO:1902337)6.90565158
11negative regulation of metanephros development (GO:0072217)6.72731135
12positive regulation of glycogen metabolic process (GO:0070875)6.71228634
13pattern specification involved in kidney development (GO:0061004)6.64951356
14female gonad development (GO:0008585)6.54014561
15bicarbonate transport (GO:0015701)6.20308612
16bone resorption (GO:0045453)5.66969237
17metanephric tubule development (GO:0072170)5.47835626
18metanephric nephron tubule development (GO:0072234)5.47835626
19mesonephros development (GO:0001823)5.44820986
20urogenital system development (GO:0001655)5.39428327
21positive regulation of cellular amine metabolic process (GO:0033240)5.23289124
22* phenol-containing compound metabolic process (GO:0018958)5.12214169
23metanephric nephron epithelium development (GO:0072243)5.04173828
24response to vitamin D (GO:0033280)4.84597635
25regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.84326489
26regulation of mesenchymal cell apoptotic process (GO:2001053)4.71230624
27positive regulation of extracellular matrix organization (GO:1903055)4.67008667
28negative regulation of hormone metabolic process (GO:0032351)4.64754300
29negative regulation of hormone biosynthetic process (GO:0032353)4.64754300
30metanephric epithelium development (GO:0072207)4.62285727
31regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.45242393
32sodium ion export (GO:0071436)4.42222165
33regulation of stem cell maintenance (GO:2000036)4.39540553
34specification of organ identity (GO:0010092)4.32625774
35mesenchymal to epithelial transition (GO:0060231)4.32356037
36negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.30061691
37positive regulation of metanephros development (GO:0072216)4.24048605
38regulation of glucocorticoid metabolic process (GO:0031943)4.19493222
39phosphatidylinositol dephosphorylation (GO:0046856)4.16860700
40regulation of myelination (GO:0031641)4.13754680
41regulation of glycogen biosynthetic process (GO:0005979)4.06863615
42regulation of glucan biosynthetic process (GO:0010962)4.06863615
43phospholipid dephosphorylation (GO:0046839)4.02451152
44positive regulation of glucose import (GO:0046326)4.02055083
45mitochondrion distribution (GO:0048311)4.01472139
46* thyroid hormone generation (GO:0006590)33.0381585
47negative regulation of kidney development (GO:0090185)3.98708336
48regulation of extracellular matrix disassembly (GO:0010715)3.88753466
49cellular potassium ion homeostasis (GO:0030007)3.88140287
50positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.69049565
51sulfur compound transport (GO:0072348)3.67354172
52positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.65092371
53cerebral cortex neuron differentiation (GO:0021895)3.58675303
54response to cadmium ion (GO:0046686)3.56187617
55hemidesmosome assembly (GO:0031581)3.52676331
56hair follicle morphogenesis (GO:0031069)3.43777210
57regulation of Rap GTPase activity (GO:0032317)3.42759349
58regulation of polysaccharide biosynthetic process (GO:0032885)3.39720591
59positive regulation of glucose transport (GO:0010828)3.36915231
60* hormone biosynthetic process (GO:0042446)3.36851572
61regulation of glycogen metabolic process (GO:0070873)3.35789558
62positive regulation of glucose metabolic process (GO:0010907)3.30640064
63forebrain neuron differentiation (GO:0021879)3.26887058
64regulation of plasminogen activation (GO:0010755)3.26854726
65regulation of microtubule polymerization (GO:0031113)3.22314996
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22070866
67carnitine metabolic process (GO:0009437)3.20588813
68nephron tubule development (GO:0072080)3.14480141
69regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14061943
70positive regulation of mesonephros development (GO:0061213)3.10949783
71regulation of energy homeostasis (GO:2000505)3.08556434
72surfactant homeostasis (GO:0043129)3.06638590
73cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.04891496
74keratan sulfate catabolic process (GO:0042340)3.03789619
75response to hydroperoxide (GO:0033194)3.03354936
76potassium ion export (GO:0071435)3.03207345
77positive regulation of digestive system process (GO:0060456)3.00562297
78* thyroid hormone metabolic process (GO:0042403)26.3232077
79Leydig cell differentiation (GO:0033327)2.98738799
80cellular response to gonadotropin stimulus (GO:0071371)2.97139351
81atrial cardiac muscle cell action potential (GO:0086014)2.96194607
82positive regulation of multicellular organism growth (GO:0040018)2.94634722
83* hydrogen peroxide catabolic process (GO:0042744)2.94351142
84thymus development (GO:0048538)2.94209841
85regulation of extracellular matrix organization (GO:1903053)2.92723322
86sodium ion homeostasis (GO:0055078)2.92631073
87cellular sodium ion homeostasis (GO:0006883)2.92201399
88regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.91870976
89protein retention in ER lumen (GO:0006621)2.90913835
90regulation of polysaccharide metabolic process (GO:0032881)2.89379097
91Rho protein signal transduction (GO:0007266)2.88794698
92phenol-containing compound catabolic process (GO:0019336)2.85413912
93renal tubule development (GO:0061326)2.83702753
94iron ion import (GO:0097286)2.82423254
95positive regulation of hormone biosynthetic process (GO:0046886)2.81336355
96positive regulation of Rap GTPase activity (GO:0032854)2.78909258
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78798671
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78415617
99* hormone metabolic process (GO:0042445)2.78318012
100cellular response to epinephrine stimulus (GO:0071872)2.77696700
101endothelial cell chemotaxis (GO:0035767)2.75491184
102cAMP metabolic process (GO:0046058)2.74729307
103membrane repolarization (GO:0086009)2.72789331
104G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72166279
105mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.70660220
106positive regulation of bone mineralization (GO:0030501)2.70005672
107regulation of steroid hormone biosynthetic process (GO:0090030)2.69943906
108icosanoid secretion (GO:0032309)2.67983976
109arachidonic acid secretion (GO:0050482)2.67983976
110peptide catabolic process (GO:0043171)2.67487802
111response to epinephrine (GO:0071871)2.65952452
112fatty acid derivative transport (GO:1901571)2.64314844
113icosanoid transport (GO:0071715)2.64314844
114adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.61742842
115negative regulation of peptide hormone secretion (GO:0090278)2.60129746
116regulation of hormone biosynthetic process (GO:0046885)2.59385291
117nephron epithelium development (GO:0072009)2.58498311
118acid secretion (GO:0046717)2.56292204
119cellular response to cAMP (GO:0071320)2.56291649
120negative regulation of epithelial to mesenchymal transition (GO:0010719)2.55856766
121epithelial cell morphogenesis (GO:0003382)2.54239537
122negative regulation of peptide secretion (GO:0002792)2.53920243
123lung secretory cell differentiation (GO:0061140)2.53288607
124regulation of mesonephros development (GO:0061217)2.52328590
125negative regulation of insulin secretion (GO:0046676)2.49749373
126positive regulation of biomineral tissue development (GO:0070169)2.49727347
127relaxation of cardiac muscle (GO:0055119)2.48584861
128ventricular cardiac muscle cell action potential (GO:0086005)2.48583466
129regulation of glucose import in response to insulin stimulus (GO:2001273)2.48403256
130* cellular modified amino acid metabolic process (GO:0006575)2.46431680
131regulation of metanephros development (GO:0072215)2.45824368
132flavonoid metabolic process (GO:0009812)2.45036679
133inorganic anion transport (GO:0015698)2.44917541
134negative regulation of fatty acid transport (GO:2000192)2.43247413
135membrane repolarization during action potential (GO:0086011)2.42438914
136hypotonic response (GO:0006971)2.41621737
137embryonic epithelial tube formation (GO:0001838)2.39738669
138potassium ion import (GO:0010107)2.35855537
139cardiovascular system development (GO:0072358)2.34518586
140lactate metabolic process (GO:0006089)2.34413614
141chemical homeostasis within a tissue (GO:0048875)2.33246177
142cell communication by electrical coupling (GO:0010644)2.31889913
143response to gonadotropin (GO:0034698)2.31526644
144regulation of pH (GO:0006885)2.31498195
145negative regulation of stem cell differentiation (GO:2000737)2.30932990
146regulation of hormone metabolic process (GO:0032350)2.29689126
147amino-acid betaine metabolic process (GO:0006577)2.29020948
148epithelial tube formation (GO:0072175)2.28713114
149negative regulation of lipase activity (GO:0060192)2.28525615
150lung vasculature development (GO:0060426)2.28376513
151positive regulation of p38MAPK cascade (GO:1900745)2.27533089
152synapse assembly (GO:0007416)2.27439410
153epithelial tube branching involved in lung morphogenesis (GO:0060441)2.27381510
154positive regulation of hormone metabolic process (GO:0032352)2.22230745
155regulation of endothelial cell chemotaxis (GO:2001026)2.21483574
156coronary vasculature morphogenesis (GO:0060977)2.18104840
157positive regulation of vascular permeability (GO:0043117)2.17082424
158regulation of clathrin-mediated endocytosis (GO:2000369)2.16288819
159positive regulation of protein kinase C signaling (GO:0090037)2.11061332
160dopaminergic neuron differentiation (GO:0071542)2.08245897
161positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.07807147
162response to iron ion (GO:0010039)2.05851077
163chloride transmembrane transport (GO:1902476)2.05604209
164positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.05223909
165regulation of glucose import (GO:0046324)2.04795267
166N-acetylneuraminate metabolic process (GO:0006054)2.04357116
167* regulation of hormone levels (GO:0010817)2.03318885
168negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.02923320
169regulation of cholesterol biosynthetic process (GO:0045540)2.00926074
170positive regulation of steroid biosynthetic process (GO:0010893)2.00852768
171response to parathyroid hormone (GO:0071107)13.4281838
172thyroid gland development (GO:0030878)12.4530021
173eye photoreceptor cell differentiation (GO:0001754)1.99757370
174photoreceptor cell differentiation (GO:0046530)1.99757370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.62022196
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons5.20363812
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.90252196
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.62339496
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80444264
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.71869526
7AR_21572438_ChIP-Seq_LNCaP_Human2.64062091
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62477213
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55956515
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55512135
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45053959
12CLOCK_20551151_ChIP-Seq_293T_Human2.43618805
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.28675579
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15333939
15DROSHA_22980978_ChIP-Seq_HELA_Human2.07074805
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02961227
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89923913
18KLF5_25053715_ChIP-Seq_YYC3_Human1.89280483
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85354153
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84656918
21NFIB_24661679_ChIP-Seq_LUNG_Mouse1.80268102
22RACK7_27058665_Chip-Seq_MCF-7_Human1.75829354
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.73624387
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73349685
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.72025946
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71559256
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71122800
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.70959621
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70271121
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.70237633
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.65476884
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64938657
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64370593
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63784986
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63042445
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.62995185
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60687871
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58741470
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56997240
40BCAT_22108803_ChIP-Seq_LS180_Human1.56377330
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55070584
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54382180
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54301408
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51711574
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.48185215
46SOX2_20726797_ChIP-Seq_SW620_Human1.47008565
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46590067
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43922519
49GATA1_22025678_ChIP-Seq_K562_Human1.43865993
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43492403
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41580867
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.39693384
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39069134
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38194917
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34306146
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31145528
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29121878
58CTCF_27219007_Chip-Seq_Bcells_Human1.27934758
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.26457479
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.26270998
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25924805
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25348727
63CJUN_26792858_Chip-Seq_BT549_Human1.23255717
64KDM2B_26808549_Chip-Seq_K562_Human1.22628992
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.22459071
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22070615
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21550798
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.20216075
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19167960
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18851679
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17341661
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17192198
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16318012
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15403287
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15042428
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.14334327
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.14235453
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14189059
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.13909811
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13518663
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.13496340
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12183949
83RNF2_27304074_Chip-Seq_NSC_Mouse1.11578178
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.11417601
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10466353
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09530677
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09309094
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09309094
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08974618
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08653414
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05712404
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05110667
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05010585
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04785124
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04695655
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03990409
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03787798
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03410447
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02996153
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.02763965
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.02763965
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02535889
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01927543
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00228799
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99969253
106IRF1_19129219_ChIP-ChIP_H3396_Human0.99244016
107EGR1_19374776_ChIP-ChIP_THP-1_Human0.98845563
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98411413
109TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98185127
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97991386
111MYC_27129775_Chip-Seq_CORNEA_Mouse0.97986558
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97850379
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97658553
114RXR_22108803_ChIP-Seq_LS180_Human0.97462922
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97155287
116NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97002448
117* RUNX2_22187159_ChIP-Seq_PCA_Human0.96884710
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96597627
119LXR_22292898_ChIP-Seq_THP-1_Human0.96295812
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95814617
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95158076
122TP63_22573176_ChIP-Seq_HFKS_Human0.94428618
123MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.92882605
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.91533008
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91414723
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91081902
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91011192
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90978914
129CREB1_26743006_Chip-Seq_LNCaP_Human0.90030984
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.89675498
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89384628
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88783526
133REST_18959480_ChIP-ChIP_MESCs_Mouse0.88474126
134TP63_23658742_ChIP-Seq_EP156T_Human0.88419838
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.88322454
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87656992
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.87515158
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87335912
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87271486
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87094916
141TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87076644
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86325550
143CDX2_22108803_ChIP-Seq_LS180_Human0.86111115
144FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85407509
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85219635
146LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84981417
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84742532
148FOXH1_21741376_ChIP-Seq_ESCs_Human0.84055163
149P68_20966046_ChIP-Seq_HELA_Human0.84033023
150ATF3_27146783_Chip-Seq_COLON_Human0.83563870
151GBX2_23144817_ChIP-Seq_PC3_Human0.82575869
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.79100831
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78520843
154* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.78202602
155* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.76982964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland8.42375779
2* MP0000681_abnormal_thyroid_gland8.31040048
3MP0000383_abnormal_hair_follicle7.52168008
4MP0010678_abnormal_skin_adnexa6.29428266
5MP0004043_abnormal_pH_regulation5.83841299
6MP0001485_abnormal_pinna_reflex4.40932853
7MP0008004_abnormal_stomach_pH3.64081246
8MP0002876_abnormal_thyroid_physiology3.28315981
9MP0001501_abnormal_sleep_pattern3.26492305
10MP0004742_abnormal_vestibular_system3.13963121
11MP0004084_abnormal_cardiac_muscle2.45996211
12MP0010234_abnormal_vibrissa_follicle2.21729561
13MP0008569_lethality_at_weaning2.14370362
14MP0008995_early_reproductive_senescence2.02138305
15MP0009250_abnormal_appendicular_skeleto1.92907592
16MP0004036_abnormal_muscle_relaxation1.88712297
17MP0003172_abnormal_lysosome_physiology1.79656365
18MP0002234_abnormal_pharynx_morphology1.77827964
19MP0003868_abnormal_feces_composition1.67107422
20MP0000462_abnormal_digestive_system1.64659210
21MP0001963_abnormal_hearing_physiology1.64585424
22MP0000026_abnormal_inner_ear1.64299551
23MP0002896_abnormal_bone_mineralization1.53821838
24MP0005508_abnormal_skeleton_morphology1.48489746
25MP0009780_abnormal_chondrocyte_physiolo1.47518121
26MP0010368_abnormal_lymphatic_system1.44035218
27MP0000566_synostosis1.43987713
28MP0005381_digestive/alimentary_phenotyp1.39460689
29MP0003938_abnormal_ear_development1.33992630
30MP0008775_abnormal_heart_ventricle1.28445452
31MP0001663_abnormal_digestive_system1.23512214
32MP0003566_abnormal_cell_adhesion1.22018704
33MP0003191_abnormal_cellular_cholesterol1.21100069
34MP0009643_abnormal_urine_homeostasis1.21080756
35MP0000920_abnormal_myelination1.20447572
36MP0003075_altered_response_to1.19763423
37MP0010771_integument_phenotype1.19643876
38MP0008438_abnormal_cutaneous_collagen1.19159986
39MP0003183_abnormal_peptide_metabolism1.15482866
40MP0001756_abnormal_urination1.09831089
41MP0003656_abnormal_erythrocyte_physiolo1.09592817
42MP0004272_abnormal_basement_membrane1.05371312
43MP0005058_abnormal_lysosome_morphology1.03554793
44MP0000534_abnormal_ureter_morphology1.02959869
45MP0009053_abnormal_anal_canal0.97933335
46MP0003890_abnormal_embryonic-extraembry0.96159825
47MP0003879_abnormal_hair_cell0.95435198
48MP0000747_muscle_weakness0.95288139
49MP0000631_abnormal_neuroendocrine_gland0.95174728
50MP0000537_abnormal_urethra_morphology0.94243223
51MP0005451_abnormal_body_composition0.89583521
52MP0005409_darkened_coat_color0.89432484
53MP0004782_abnormal_surfactant_physiolog0.85916447
54MP0002102_abnormal_ear_morphology0.84319626
55MP0000163_abnormal_cartilage_morphology0.79785640
56MP0002796_impaired_skin_barrier0.78261942
57MP0000049_abnormal_middle_ear0.77318733
58MP0008875_abnormal_xenobiotic_pharmacok0.68807008
59MP0003303_peritoneal_inflammation0.68734347
60MP0002229_neurodegeneration0.68413842
61MP0003755_abnormal_palate_morphology0.68280110
62MP0005165_increased_susceptibility_to0.68270036
63MP0005390_skeleton_phenotype0.67632069
64MP0002735_abnormal_chemical_nociception0.67523698
65MP0001879_abnormal_lymphatic_vessel0.67387498
66MP0003329_amyloid_beta_deposits0.66198866
67MP0000762_abnormal_tongue_morphology0.64021901
68MP0002295_abnormal_pulmonary_circulatio0.61835171
69MP0005647_abnormal_sex_gland0.60769283
70MP0005166_decreased_susceptibility_to0.60516744
71MP0003638_abnormal_response/metabolism_0.60347429
72MP0002060_abnormal_skin_morphology0.59889165
73MP0005636_abnormal_mineral_homeostasis0.59667903
74MP0002332_abnormal_exercise_endurance0.59574065
75MP0004134_abnormal_chest_morphology0.58405318
76MP0003195_calcinosis0.58234596
77MP0004885_abnormal_endolymph0.58193575
78MP0008961_abnormal_basal_metabolism0.58169178
79MP0002089_abnormal_postnatal_growth/wei0.56444254
80MP0001765_abnormal_ion_homeostasis0.55482106
81MP0003137_abnormal_impulse_conducting0.54206054
82MP0003795_abnormal_bone_structure0.53975138
83MP0001346_abnormal_lacrimal_gland0.53525570
84MP0003878_abnormal_ear_physiology0.53301931
85MP0001440_abnormal_grooming_behavior0.52324257
86MP0003935_abnormal_craniofacial_develop0.51897675
87MP0002098_abnormal_vibrissa_morphology0.51252872
88MP0001348_abnormal_lacrimal_gland0.49965306
89MP0002972_abnormal_cardiac_muscle0.49809484
90MP0004484_altered_response_of0.49411969
91MP0005623_abnormal_meninges_morphology0.49183221
92MP0003646_muscle_fatigue0.49168150
93MP0005076_abnormal_cell_differentiation0.49031426
94MP0001984_abnormal_olfaction0.48999639
95MP0003119_abnormal_digestive_system0.48692730
96MP0005023_abnormal_wound_healing0.47758808
97MP0001849_ear_inflammation0.46234610
98MP0002136_abnormal_kidney_physiology0.45320400
99MP0005319_abnormal_enzyme/_coenzyme0.44698238
100MP0002177_abnormal_outer_ear0.44645793
101MP0003011_delayed_dark_adaptation0.44455092
102MP0004185_abnormal_adipocyte_glucose0.43829500
103MP0002272_abnormal_nervous_system0.43737624
104MP0009745_abnormal_behavioral_response0.43270069
105MP0003115_abnormal_respiratory_system0.42897663
106* MP0005584_abnormal_enzyme/coenzyme_acti0.42774778
107MP0002063_abnormal_learning/memory/cond0.42701067
108MP0005360_urolithiasis0.42629355
109MP0005595_abnormal_vascular_smooth0.42538669
110MP0004264_abnormal_extraembryonic_tissu0.42224774
111MP0002116_abnormal_craniofacial_bone0.41561517
112MP0004130_abnormal_muscle_cell0.40301520
113MP0003698_abnormal_male_reproductive0.39921409
114MP0001502_abnormal_circadian_rhythm0.39813503
115* MP0003953_abnormal_hormone_level0.38593503
116MP0010386_abnormal_urinary_bladder0.38422355
117MP0005620_abnormal_muscle_contractility0.38421683
118MP0002282_abnormal_trachea_morphology0.38328820
119MP0002113_abnormal_skeleton_development0.38131335
120MP0004147_increased_porphyrin_level0.37256210
121MP0005365_abnormal_bile_salt0.36034179
122MP0006138_congestive_heart_failure0.35851872
123MP0001270_distended_abdomen0.35478411
124MP0009764_decreased_sensitivity_to0.35288648
125MP0005377_hearing/vestibular/ear_phenot0.34930882
126MP0005310_abnormal_salivary_gland0.33871113
127MP0001958_emphysema0.33512205
128MP0003936_abnormal_reproductive_system0.33493213
129MP0002877_abnormal_melanocyte_morpholog0.32738575
130MP0001177_atelectasis0.32628827
131MP0002118_abnormal_lipid_homeostasis0.31526746
132MP0001731_abnormal_postnatal_growth0.30725340
133MP0000003_abnormal_adipose_tissue0.27279706
134* MP0009642_abnormal_blood_homeostasis0.26504480
135MP0000372_irregular_coat_pigmentation0.25954783
136MP0001145_abnormal_male_reproductive0.25873855
137MP0002752_abnormal_somatic_nervous0.25608321
138MP0001188_hyperpigmentation0.25247683
139MP0002822_catalepsy0.24899963
140MP0006036_abnormal_mitochondrial_physio0.23137616
141MP0003937_abnormal_limbs/digits/tail_de0.22349180
142MP0000367_abnormal_coat/_hair0.22334681
143MP0002092_abnormal_eye_morphology0.21198112
144MP0000653_abnormal_sex_gland0.20928212
145MP0005375_adipose_tissue_phenotype0.20691115
146MP0002168_other_aberrant_phenotype0.19434121
147MP0003699_abnormal_female_reproductive0.19308702
148MP0003136_yellow_coat_color0.18109028
149MP0001929_abnormal_gametogenesis0.17958001
150MP0010030_abnormal_orbit_morphology0.17712469
151MP0004381_abnormal_hair_follicle0.17451807
152MP0005666_abnormal_adipose_tissue0.17279434
153MP0005075_abnormal_melanosome_morpholog0.16779596
154MP0003942_abnormal_urinary_system0.16690344
155MP0001664_abnormal_digestion0.15281604
156MP0009703_decreased_birth_body0.14475875
157MP0000377_abnormal_hair_follicle0.14408237
158MP0002653_abnormal_ependyma_morphology0.14173576

Predicted human phenotypes

RankGene SetZ-score
1Tetany (HP:0001281)9.52078087
2Abnormality of cochlea (HP:0000375)9.12281850
3Abnormal hair laboratory examination (HP:0003328)9.08586322
4Hyperphosphatemia (HP:0002905)8.40503231
5Hyperthyroidism (HP:0000836)8.11233836
6* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)7.57158849
7Morphological abnormality of the inner ear (HP:0011390)7.19445552
8Delayed epiphyseal ossification (HP:0002663)7.18736304
9Irregular epiphyses (HP:0010582)6.44976558
10Mild short stature (HP:0003502)5.90728417
11Thyroid carcinoma (HP:0002890)5.50347892
12Hypothermia (HP:0002045)5.43349986
13Onycholysis (HP:0001806)5.32684247
14Hypoparathyroidism (HP:0000829)5.31127692
15Epiphyseal dysplasia (HP:0002656)5.10432764
16Hyperparathyroidism (HP:0000843)4.31532606
17Cervical subluxation (HP:0003308)4.14124699
18* Hypothyroidism (HP:0000821)4.10667401
19Delayed CNS myelination (HP:0002188)3.71919120
20Mucopolysacchariduria (HP:0008155)3.51378006
21Urinary glycosaminoglycan excretion (HP:0003541)3.51378006
22Ulnar deviation of the wrist (HP:0003049)3.46207841
23* Coarse facial features (HP:0000280)3.34328180
24Tracheal stenosis (HP:0002777)3.29020867
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25074202
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25074202
27Abnormality of polysaccharide metabolism (HP:0011012)3.25074202
28Hyperactive renin-angiotensin system (HP:0000841)3.19011586
29Disproportionate short-trunk short stature (HP:0003521)2.99764614
30Neonatal respiratory distress (HP:0002643)2.93377375
31Neoplasm of the thyroid gland (HP:0100031)2.76062704
32Hyperpituitarism (HP:0010514)2.75459870
33Muscle fiber splitting (HP:0003555)2.72267356
34Prenatal maternal abnormality (HP:0002686)2.70980128
35* Constipation (HP:0002019)2.70655722
36Hypocalcemia (HP:0002901)2.70047542
37Hypoplasia of the odontoid process (HP:0003311)2.60808754
38Split foot (HP:0001839)2.52672477
39Genu varum (HP:0002970)2.49507627
40Chronic bronchitis (HP:0004469)2.40114819
41Abnormality of the vitreous humor (HP:0004327)2.34936133
42Partial duplication of thumb phalanx (HP:0009944)2.25056160
43Broad metatarsal (HP:0001783)2.21985026
44Abnormality of the odontoid process (HP:0003310)2.15227206
45Urethral obstruction (HP:0000796)2.15087794
46Ventricular fibrillation (HP:0001663)2.14587626
47Bradycardia (HP:0001662)2.12556145
48Hoarse voice (HP:0001609)2.06690312
49Atrophic scars (HP:0001075)2.05924521
50Abnormality of the dental root (HP:0006486)2.02837009
51Taurodontia (HP:0000679)2.02837009
52Abnormality of permanent molar morphology (HP:0011071)2.02837009
53Pili torti (HP:0003777)14.6843947
54* Goiter (HP:0000853)13.1990140
55Thyroid-stimulating hormone excess (HP:0002925)10.6781866
56Small epiphyses (HP:0010585)10.5333266
57Congenital sensorineural hearing impairment (HP:0008527)10.5184372
58Ovoid vertebral bodies (HP:0003300)1.99065480
59Partial duplication of the phalanx of hand (HP:0009999)1.99013136
60Fragile nails (HP:0001808)1.93751967
61Distal upper limb amyotrophy (HP:0007149)1.93603425
62Upper limb amyotrophy (HP:0009129)1.93603425
63Obstructive sleep apnea (HP:0002870)1.90900711
64Accelerated skeletal maturation (HP:0005616)1.89318852
65Abnormality of molar (HP:0011077)1.88586406
66Abnormality of molar morphology (HP:0011070)1.88586406
67Abnormal epiphyseal ossification (HP:0010656)1.87153193
68Nonprogressive disorder (HP:0003680)1.84715453
69Milia (HP:0001056)1.84090950
70Asymmetry of the thorax (HP:0001555)1.83014253
71Bronchomalacia (HP:0002780)1.82916256
72Synostosis involving the elbow (HP:0003938)1.81569249
73Humeroradial synostosis (HP:0003041)1.81569249
74Abnormality of the dental pulp (HP:0006479)1.80206011
75Abnormality of the antihelix (HP:0009738)1.77972444
76Lower limb asymmetry (HP:0100559)1.77300208
77Difficulty running (HP:0009046)1.74636654
78Flat acetabular roof (HP:0003180)1.74554762
79Difficulty climbing stairs (HP:0003551)1.70841361
80Generalized amyotrophy (HP:0003700)1.70806458
81Type I diabetes mellitus (HP:0100651)1.70242966
82Limb-girdle muscle atrophy (HP:0003797)1.69764245
83Neonatal hypoglycemia (HP:0001998)1.68551362
84Hand muscle atrophy (HP:0009130)1.68439626
85Aplasia of the musculature (HP:0100854)1.66684920
86Respiratory distress (HP:0002098)1.65706335
87Osteoarthritis (HP:0002758)1.64072696
88Hyperkalemia (HP:0002153)1.58472648
89Abnormality of chloride homeostasis (HP:0011422)1.58102607
90Abnormality of the distal phalanges of the toes (HP:0010182)1.55945474
91Vaginal fistula (HP:0004320)1.55181335
92* Umbilical hernia (HP:0001537)1.53564332
93Vertigo (HP:0002321)1.52801566
94Increased connective tissue (HP:0009025)1.52572314
95Abnormality of the middle phalanges of the toes (HP:0010183)1.51276600
96Sleep apnea (HP:0010535)1.50365066
97Neurofibrillary tangles (HP:0002185)1.50183023
98Ulnar bowing (HP:0003031)1.44831547
99Distal lower limb muscle weakness (HP:0009053)1.44766132
100Stridor (HP:0010307)1.43293797
101Increased density of long bones (HP:0006392)1.41784086
102Rectal fistula (HP:0100590)1.41386680
103Rectovaginal fistula (HP:0000143)1.41386680
104Right ventricular cardiomyopathy (HP:0011663)1.41189908
105Choanal atresia (HP:0000453)1.40657885
106Abnormal hemoglobin (HP:0011902)1.40450636
107Prolonged QT interval (HP:0001657)1.39734282
108Syncope (HP:0001279)1.39121314
109Hypoplastic nipples (HP:0002557)1.38934221
110Decreased circulating renin level (HP:0003351)1.38360789
111Lower limb hyperreflexia (HP:0002395)1.37492501
112Hyperaldosteronism (HP:0000859)1.37393552
113Cerebral inclusion bodies (HP:0100314)1.36612319
114Bifid scrotum (HP:0000048)1.36196204
115Renal salt wasting (HP:0000127)1.35125807
116Shallow orbits (HP:0000586)1.35092328
117Abnormality of the vocal cords (HP:0008777)1.34927525
118Breast hypoplasia (HP:0003187)1.34673348
119Hypokinesia (HP:0002375)1.34547290
120Achilles tendon contracture (HP:0001771)1.33669048
121Carpal bone hypoplasia (HP:0001498)1.33566458
122Abnormality of the Achilles tendon (HP:0005109)1.32549375
123Abnormality of dental color (HP:0011073)1.30727720
124Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.29909590
125Back pain (HP:0003418)1.29315493
126Macroglossia (HP:0000158)1.28680601
127Fetal akinesia sequence (HP:0001989)1.27374066
128Thoracolumbar scoliosis (HP:0002944)1.26605717
129Abdominal distention (HP:0003270)1.25960962
130Inability to walk (HP:0002540)1.25250631
131Anxiety (HP:0000739)1.24937406
132Clonus (HP:0002169)1.24478698
133Abnormality of renin-angiotensin system (HP:0000847)1.23034468
134Small for gestational age (HP:0001518)1.21948063
135Diaphragmatic weakness (HP:0009113)1.21788606
136Lethargy (HP:0001254)1.21754352
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.21224804
138Abnormal vertebral ossification (HP:0100569)1.20953039
139Spinal muscular atrophy (HP:0007269)1.20273836
140Large for gestational age (HP:0001520)1.14664535
141Sporadic (HP:0003745)1.13203017
142Hyperbilirubinemia (HP:0002904)1.08198627
143Adrenal overactivity (HP:0002717)1.08015816
144Metabolic alkalosis (HP:0200114)1.07359939
145Nephropathy (HP:0000112)1.06652450
146Hypercortisolism (HP:0001578)1.04872709
147Premature birth (HP:0001622)1.03231041
148Labial hypoplasia (HP:0000066)1.02711066
149Laryngomalacia (HP:0001601)1.01668473
150Truncal obesity (HP:0001956)1.01642799
151Choanal stenosis (HP:0000452)0.99449956
152Abnormal EKG (HP:0003115)0.94207873
153Genu valgum (HP:0002857)0.94123762
154Sparse lateral eyebrow (HP:0005338)0.92792883
155Hypoplastic female external genitalia (HP:0012815)0.92027655
156Dysdiadochokinesis (HP:0002075)0.91355630
157Striae distensae (HP:0001065)0.91140095
158Seborrheic dermatitis (HP:0001051)0.90319456
159Abnormality of the axillary hair (HP:0100134)0.90206357
160Abnormality of secondary sexual hair (HP:0009888)0.90206357
161Platyspondyly (HP:0000926)0.87817541
162Astigmatism (HP:0000483)0.86815095
163Retinopathy (HP:0000488)0.86805590
164Ventricular arrhythmia (HP:0004308)0.84781778
165Clitoromegaly (HP:0000057)0.84727909
166Dry skin (HP:0000958)0.83867592
167Bowing of the arm (HP:0006488)0.80438933
168Bowed forearm bones (HP:0003956)0.80438933
169Late onset (HP:0003584)0.78560113
170Germ cell neoplasia (HP:0100728)0.76966686
171Hyponatremia (HP:0002902)0.75578961
172Hypokalemic alkalosis (HP:0001949)0.75215335
173Polyhydramnios (HP:0001561)0.73662915
174Micromelia (HP:0002983)0.69780233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.50343730
2DAPK24.01896832
3MST43.31673397
4KSR23.17770945
5ERBB33.13840511
6ERN12.62489489
7AKT32.51700013
8FGFR22.46816593
9RIPK12.36385830
10MAP3K92.30793215
11NTRK12.20859967
12PAK32.15111013
13RET2.10945332
14NEK12.10680165
15TRPM72.06495451
16LRRK22.04181071
17FER1.95564389
18EPHB11.90382766
19DAPK11.73512108
20PAK41.67985448
21MAP3K21.51993674
22MYLK1.51007250
23PHKG21.48195013
24PHKG11.48195013
25SIK11.48047216
26MAP2K11.45297452
27CAMK1D1.44633918
28PTK61.43045024
29SMG11.39593778
30PTK21.37829277
31CDK121.35777175
32LMTK21.30421364
33LATS21.25748679
34PKN21.14497139
35BCR1.14419353
36DAPK31.14247709
37PINK11.13697907
38MAP2K21.06412852
39CAMK1G1.05225797
40LATS11.04527714
41EPHB21.02163017
42RIPK41.02034274
43ARAF0.99499916
44CSNK1G20.98693629
45PDK10.98239229
46MAPK120.97389545
47DDR20.95380963
48PAK60.95356605
49BMPR20.95078598
50STK380.95045172
51KSR10.93161962
52STK240.92324887
53EPHA40.90252903
54MAPKAPK30.90170305
55BRD40.89875495
56PRKCI0.88503697
57CAMKK20.85161609
58BCKDK0.81696493
59NLK0.80604343
60STK100.79855535
61TTN0.79430241
62TESK10.78682966
63PDK30.78503677
64PDK40.78503677
65TTK0.78380236
66FGFR10.75954686
67CAMKK10.73423398
68CLK10.73007225
69FRK0.72707837
70ROCK20.72061707
71JAK20.71178684
72PTK2B0.71144624
73TAF10.70590179
74TIE10.69041362
75PNCK0.68479431
76DMPK0.67757316
77TAOK30.66091305
78RPS6KA20.66063628
79MATK0.65710831
80PLK30.65699113
81EEF2K0.65484804
82PRKCZ0.64897092
83ERBB40.63211136
84HIPK20.59003953
85TBK10.57165081
86FES0.55869931
87MAPKAPK20.55786288
88CSF1R0.55534998
89ILK0.54682491
90JAK10.54232641
91RAF10.54096668
92TYRO30.53161753
93MAP3K10.52972249
94MAP3K130.51707772
95CSNK1A10.51492353
96FGFR40.49710803
97RPS6KB10.49470956
98SRC0.49046014
99MAPK70.47146173
100MAP3K70.46725610
101GRK10.45979421
102ADRBK10.45964273
103PDPK10.45390578
104ROCK10.45039127
105MINK10.44981461
106NEK60.43895413
107EPHA30.42252110
108TAOK10.41435401
109PRKD10.41122164
110YES10.40976508
111MAP3K80.40913126
112PDGFRA0.39974898
113STK390.39892299
114ERBB20.39091630
115EGFR0.37976748
116CDK30.36708558
117PAK10.36604953
118MTOR0.36475989
119STK30.35990441
120PRKCG0.35717296
121FGR0.35205391
122KDR0.32710750
123PRKD20.32484991
124CDK50.32320841
125EPHA20.31748851
126PRKACB0.31294892
127MAP3K120.31029837
128PRKACG0.30578059
129PDK20.30433708
130MELK0.30167495
131CHUK0.30133571
132SCYL20.29571832
133AURKA0.29494925
134RPS6KC10.29459177
135RPS6KL10.29459177
136CDK140.29444988
137INSRR0.29400542
138UHMK10.28270804
139HCK0.27649436
140RPS6KA10.27320398
141FYN0.27103958
142IRAK30.26923974
143IRAK20.26816776
144MAP2K60.26719817
145MAPK40.26460019
146GRK50.25771990
147RPS6KA60.23647397
148KIT0.23323276
149AKT20.23273087
150PRPF4B0.22907600
151BTK0.21822552
152PRKD30.20707587
153CDK90.20706344
154EIF2AK20.19167657
155CAMK40.19083226
156NME10.18691841
157MAPK80.17908889
158EIF2AK30.17474062
159GSK3B0.17027545
160EIF2AK10.16257880
161PRKACA0.16123805
162INSR0.15956959
163LIMK10.15803490
164TYK20.14741676

Predicted pathways (KEGG)

RankGene SetZ-score
1* Autoimmune thyroid disease_Homo sapiens_hsa053207.15440765
2* Thyroid hormone synthesis_Homo sapiens_hsa049186.42478574
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.82600078
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74408535
5Gastric acid secretion_Homo sapiens_hsa049712.54449574
6Mineral absorption_Homo sapiens_hsa049782.31984786
7Sulfur metabolism_Homo sapiens_hsa009202.13470448
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.09790079
9Bile secretion_Homo sapiens_hsa049762.02159736
10Arginine biosynthesis_Homo sapiens_hsa002201.57306815
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54934636
12Histidine metabolism_Homo sapiens_hsa003401.45619279
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26711274
14Inositol phosphate metabolism_Homo sapiens_hsa005621.23461290
15Thyroid cancer_Homo sapiens_hsa052161.22501134
16Lysosome_Homo sapiens_hsa041421.14040193
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12068116
18ECM-receptor interaction_Homo sapiens_hsa045121.02663577
19Amoebiasis_Homo sapiens_hsa051461.02634311
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01727119
21Bladder cancer_Homo sapiens_hsa052190.99819790
22N-Glycan biosynthesis_Homo sapiens_hsa005100.96100289
23VEGF signaling pathway_Homo sapiens_hsa043700.95707181
24Linoleic acid metabolism_Homo sapiens_hsa005910.94456761
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93463242
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92546953
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91979178
28Fatty acid degradation_Homo sapiens_hsa000710.90447126
29Glutathione metabolism_Homo sapiens_hsa004800.90332708
30Phototransduction_Homo sapiens_hsa047440.89535367
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89218395
32Salivary secretion_Homo sapiens_hsa049700.87667071
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87655902
34Renal cell carcinoma_Homo sapiens_hsa052110.86780336
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85868190
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85792901
37Nitrogen metabolism_Homo sapiens_hsa009100.84571829
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.81840906
39Other glycan degradation_Homo sapiens_hsa005110.80050781
40Renin secretion_Homo sapiens_hsa049240.79249273
41Small cell lung cancer_Homo sapiens_hsa052220.79146163
42Lysine degradation_Homo sapiens_hsa003100.78191344
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.77887324
44Vitamin B6 metabolism_Homo sapiens_hsa007500.77465609
45Vibrio cholerae infection_Homo sapiens_hsa051100.76985538
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76090433
47Arginine and proline metabolism_Homo sapiens_hsa003300.74966824
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74703535
49Pyruvate metabolism_Homo sapiens_hsa006200.73501303
50mTOR signaling pathway_Homo sapiens_hsa041500.72511056
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.72092063
52beta-Alanine metabolism_Homo sapiens_hsa004100.71970463
53Circadian rhythm_Homo sapiens_hsa047100.68924136
54Estrogen signaling pathway_Homo sapiens_hsa049150.68751855
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68284395
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67713811
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65499543
58Focal adhesion_Homo sapiens_hsa045100.65335777
59TGF-beta signaling pathway_Homo sapiens_hsa043500.65014246
60Amphetamine addiction_Homo sapiens_hsa050310.64645455
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63275709
62Melanogenesis_Homo sapiens_hsa049160.61521866
63Selenocompound metabolism_Homo sapiens_hsa004500.60814082
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60234172
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59844897
66Glioma_Homo sapiens_hsa052140.59512552
67Protein digestion and absorption_Homo sapiens_hsa049740.58378507
68Endometrial cancer_Homo sapiens_hsa052130.58094716
69Long-term potentiation_Homo sapiens_hsa047200.56125030
70Glucagon signaling pathway_Homo sapiens_hsa049220.55916064
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55731735
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55082415
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54409342
74GnRH signaling pathway_Homo sapiens_hsa049120.54130708
75Glycerolipid metabolism_Homo sapiens_hsa005610.53842239
76Arachidonic acid metabolism_Homo sapiens_hsa005900.53537459
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53154818
78Prion diseases_Homo sapiens_hsa050200.52768369
79Fat digestion and absorption_Homo sapiens_hsa049750.52531795
80Olfactory transduction_Homo sapiens_hsa047400.52002133
81Oxytocin signaling pathway_Homo sapiens_hsa049210.49214139
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49185941
83Circadian entrainment_Homo sapiens_hsa047130.49143276
84Butanoate metabolism_Homo sapiens_hsa006500.48560863
85Proteoglycans in cancer_Homo sapiens_hsa052050.48409746
86Collecting duct acid secretion_Homo sapiens_hsa049660.47342017
87Synaptic vesicle cycle_Homo sapiens_hsa047210.46746475
88Ether lipid metabolism_Homo sapiens_hsa005650.45660394
89Propanoate metabolism_Homo sapiens_hsa006400.44310442
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43543813
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42914999
92Cardiac muscle contraction_Homo sapiens_hsa042600.42889038
93cAMP signaling pathway_Homo sapiens_hsa040240.42837791
94Antigen processing and presentation_Homo sapiens_hsa046120.40812137
95Insulin secretion_Homo sapiens_hsa049110.40479478
96Phenylalanine metabolism_Homo sapiens_hsa003600.40006766
97Tryptophan metabolism_Homo sapiens_hsa003800.39969190
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39611589
99Dopaminergic synapse_Homo sapiens_hsa047280.39436108
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.38770140
101GABAergic synapse_Homo sapiens_hsa047270.38434096
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37813559
103Cocaine addiction_Homo sapiens_hsa050300.37562450
104Insulin resistance_Homo sapiens_hsa049310.35408911
105Carbon metabolism_Homo sapiens_hsa012000.35348582
106Pancreatic secretion_Homo sapiens_hsa049720.34816702
107Insulin signaling pathway_Homo sapiens_hsa049100.34030521
108Tight junction_Homo sapiens_hsa045300.32277854
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.32258484
110Peroxisome_Homo sapiens_hsa041460.31664440
111Hippo signaling pathway_Homo sapiens_hsa043900.31617029
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31178029
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30901656
114Cholinergic synapse_Homo sapiens_hsa047250.30500246
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30319854
116Ras signaling pathway_Homo sapiens_hsa040140.30199066
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.30032930
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29782421
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29756831
120AMPK signaling pathway_Homo sapiens_hsa041520.29619829
121HIF-1 signaling pathway_Homo sapiens_hsa040660.29278517
122Pancreatic cancer_Homo sapiens_hsa052120.28714659
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28649622
124Dorso-ventral axis formation_Homo sapiens_hsa043200.28556164
125Prostate cancer_Homo sapiens_hsa052150.28329504
126Protein export_Homo sapiens_hsa030600.27076978
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26469884
128Chemical carcinogenesis_Homo sapiens_hsa052040.26169371
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26151166
130Sphingolipid metabolism_Homo sapiens_hsa006000.26059316
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.22112825
132Fructose and mannose metabolism_Homo sapiens_hsa000510.21009640
133Rap1 signaling pathway_Homo sapiens_hsa040150.20623645
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.20400885
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19776584
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15491938
137Acute myeloid leukemia_Homo sapiens_hsa052210.14038604
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10942099
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10329111
140* Metabolic pathways_Homo sapiens_hsa011000.09548869
141Colorectal cancer_Homo sapiens_hsa052100.09280483
142Sulfur relay system_Homo sapiens_hsa041220.09099576
143PPAR signaling pathway_Homo sapiens_hsa033200.08015471
144Hepatitis C_Homo sapiens_hsa051600.07186890
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.06389058
146Hedgehog signaling pathway_Homo sapiens_hsa043400.06348472
147Pathways in cancer_Homo sapiens_hsa052000.04927679
148Melanoma_Homo sapiens_hsa052180.03759980
149Adherens junction_Homo sapiens_hsa045200.03092460
150Choline metabolism in cancer_Homo sapiens_hsa052310.02310547

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