TPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.78231772
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.78231772
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.78231772
4modulation by symbiont of host immune response (GO:0052553)4.78231772
5positive regulation by symbiont of host defense response (GO:0052509)4.78231772
6modulation by symbiont of host defense response (GO:0052031)4.78231772
7regulation of interferon-beta biosynthetic process (GO:0045357)4.45383152
8positive regulation of gamma-delta T cell activation (GO:0046645)4.19547629
9immunoglobulin mediated immune response (GO:0016064)3.97606961
10negative regulation of erythrocyte differentiation (GO:0045647)3.76824464
11negative regulation of interleukin-12 production (GO:0032695)3.67914673
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67186332
13negative regulation of cell killing (GO:0031342)3.67186332
14macrophage activation involved in immune response (GO:0002281)3.65274604
15antigen processing and presentation of endogenous antigen (GO:0019883)3.62842883
16apoptotic cell clearance (GO:0043277)3.61284733
17detection of other organism (GO:0098543)3.50764771
18regulation of mast cell degranulation (GO:0043304)3.43383070
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41355188
20detection of bacterium (GO:0016045)3.34151241
21microglial cell activation (GO:0001774)3.27441376
22positive regulation of mast cell activation (GO:0033005)3.26894789
23regulation of leukocyte degranulation (GO:0043300)3.25596193
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22536426
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21894439
26response to host immune response (GO:0052572)3.21894439
27cellular extravasation (GO:0045123)3.19098262
28regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19091303
29granulocyte activation (GO:0036230)3.18031483
30positive regulation of mast cell degranulation (GO:0043306)3.17187127
31positive regulation of mast cell activation involved in immune response (GO:0033008)3.17187127
32mannose metabolic process (GO:0006013)3.16857715
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16406591
34regulation of cholesterol storage (GO:0010885)3.11652204
35detection of external biotic stimulus (GO:0098581)3.11454747
36regulation of mast cell activation involved in immune response (GO:0033006)3.10925111
37neutrophil activation (GO:0042119)3.09430508
38neutrophil activation involved in immune response (GO:0002283)3.09385077
39response to host (GO:0075136)3.07171065
40response to host defenses (GO:0052200)3.07171065
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07171065
42positive regulation of interferon-alpha production (GO:0032727)3.04287629
43regulation of gamma-delta T cell activation (GO:0046643)3.03446888
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00927740
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98956145
46interferon-gamma-mediated signaling pathway (GO:0060333)2.98529760
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98131852
48alpha-linolenic acid metabolic process (GO:0036109)2.98048299
49detection of molecule of bacterial origin (GO:0032490)2.95498398
50positive regulation of cellular amide metabolic process (GO:0034250)2.94570779
51keratan sulfate catabolic process (GO:0042340)2.93655736
52response to thyroid hormone (GO:0097066)2.92590324
53B cell mediated immunity (GO:0019724)2.92267292
54regulation of T-helper 2 cell differentiation (GO:0045628)2.91520785
55amino sugar catabolic process (GO:0046348)2.88468037
56response to muramyl dipeptide (GO:0032495)2.88365541
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87341589
58adhesion of symbiont to host (GO:0044406)2.87331143
59positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86985033
60regulation of interferon-alpha production (GO:0032647)2.85624697
61low-density lipoprotein particle clearance (GO:0034383)2.85030089
62glycolipid catabolic process (GO:0019377)2.84772076
63T-helper 1 type immune response (GO:0042088)2.83817563
64peptidyl-glutamic acid carboxylation (GO:0017187)2.83320227
65protein carboxylation (GO:0018214)2.83320227
66negative regulation of cytokine production involved in immune response (GO:0002719)2.81029751
67pinocytosis (GO:0006907)2.79482615
68virion attachment to host cell (GO:0019062)2.79449189
69adhesion of symbiont to host cell (GO:0044650)2.79449189
70germinal center formation (GO:0002467)2.78757823
71regulation of mast cell activation (GO:0033003)2.78054987
72oligosaccharide catabolic process (GO:0009313)2.77142577
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.76613976
74detection of biotic stimulus (GO:0009595)2.74758280
75regulation of antigen processing and presentation (GO:0002577)2.74042939
76regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71393856
77cell adhesion mediated by integrin (GO:0033627)2.70400045
78hyaluronan catabolic process (GO:0030214)2.68535684
79positive regulation of antigen processing and presentation (GO:0002579)2.67142441
80positive regulation of B cell differentiation (GO:0045579)2.66841861
81cellular response to thyroid hormone stimulus (GO:0097067)2.66491046
82macrophage activation (GO:0042116)2.64539891
83plasma lipoprotein particle clearance (GO:0034381)2.64511686
84positive regulation of type 2 immune response (GO:0002830)2.60746943
85regulation of regulated secretory pathway (GO:1903305)2.60471613
86positive regulation of hemostasis (GO:1900048)2.58831327
87positive regulation of blood coagulation (GO:0030194)2.58831327
88regulation of T cell tolerance induction (GO:0002664)2.57348754
89basement membrane organization (GO:0071711)2.56235380
90negative regulation of response to reactive oxygen species (GO:1901032)2.54534196
91regulation of gamma-delta T cell differentiation (GO:0045586)2.54207161
92regulation of mononuclear cell migration (GO:0071675)2.54156109
93myeloid dendritic cell differentiation (GO:0043011)2.54102804
94negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.53423562
95regulation of membrane protein ectodomain proteolysis (GO:0051043)2.53258609
96regulation of tolerance induction (GO:0002643)2.53190940
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52503029
98response to laminar fluid shear stress (GO:0034616)2.52303918
99positive regulation of coagulation (GO:0050820)2.50459750
100positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.50035233
101toxin transport (GO:1901998)2.49513206
102positive regulation of p38MAPK cascade (GO:1900745)2.49277951
103regulation of macrophage cytokine production (GO:0010935)2.48799871
104regulation of B cell receptor signaling pathway (GO:0050855)2.48020242
105lysine catabolic process (GO:0006554)2.47601300
106lysine metabolic process (GO:0006553)2.47601300
107response to lipoprotein particle (GO:0055094)2.47254098
108regulation of type 2 immune response (GO:0002828)2.46805043
109regulation of T-helper 1 cell differentiation (GO:0045625)2.45255782
110cellular response to type I interferon (GO:0071357)2.44945467
111type I interferon signaling pathway (GO:0060337)2.44945467
112ceramide catabolic process (GO:0046514)2.44899518
113antigen processing and presentation via MHC class Ib (GO:0002475)2.44112617
114myeloid dendritic cell activation (GO:0001773)2.43432320
115response to type I interferon (GO:0034340)2.42415588
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.42306742
117negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42248020
118carnitine metabolic process (GO:0009437)2.40386855
119reverse cholesterol transport (GO:0043691)2.39751218
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.39688544
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39329683
122low-density lipoprotein particle remodeling (GO:0034374)2.39005192
123positive thymic T cell selection (GO:0045059)2.38533227
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37082086
125negative regulation of lipid storage (GO:0010888)2.36671140
126myeloid leukocyte activation (GO:0002274)2.36115975
127negative regulation of leukocyte mediated immunity (GO:0002704)2.35760689
128positive regulation of tumor necrosis factor production (GO:0032760)2.34895882
129amyloid precursor protein catabolic process (GO:0042987)2.34154376
130valine metabolic process (GO:0006573)2.33815850
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33614312
132complement activation, alternative pathway (GO:0006957)2.33187142
133sulfur amino acid catabolic process (GO:0000098)2.33013580
134phospholipid homeostasis (GO:0055091)2.31849550
135regulation of hypersensitivity (GO:0002883)2.30822512
136I-kappaB phosphorylation (GO:0007252)2.30572851
137protein-lipid complex assembly (GO:0065005)2.30570225
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30565005
139cellular response to interferon-gamma (GO:0071346)2.30471692
140N-acetylneuraminate metabolic process (GO:0006054)2.30291346
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30113595
142positive regulation of leukocyte degranulation (GO:0043302)2.26596343
143protein-lipid complex subunit organization (GO:0071825)2.26571089
144ethanol oxidation (GO:0006069)2.26330783
145regulation of complement activation (GO:0030449)2.25309634
146amino-acid betaine metabolic process (GO:0006577)2.24588527
147lipoprotein metabolic process (GO:0042157)2.24420995
148glycosphingolipid catabolic process (GO:0046479)2.21411723
149regulation of protein activation cascade (GO:2000257)2.20921858
150regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20767542
151glyoxylate metabolic process (GO:0046487)2.20455239
152regulation of macrophage chemotaxis (GO:0010758)2.20289914
153regulation of apoptotic cell clearance (GO:2000425)2.20038366
154cysteine metabolic process (GO:0006534)2.19291852
155phagocytosis, engulfment (GO:0006911)2.19094348
156regulation of hydrogen peroxide-induced cell death (GO:1903205)2.19044299
157respiratory burst (GO:0045730)2.18798725
158import into cell (GO:0098657)2.18690054
159lipoprotein transport (GO:0042953)2.18650983
160cholesterol efflux (GO:0033344)2.18505344
161positive regulation of phagocytosis (GO:0050766)2.17315898
162regulation of monocyte chemotaxis (GO:0090025)2.17092072
163plasma lipoprotein particle organization (GO:0071827)2.16234420
164positive regulation of triglyceride biosynthetic process (GO:0010867)2.16041938
165erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.15332661
166L-phenylalanine catabolic process (GO:0006559)2.15332661
167response to peptidoglycan (GO:0032494)2.14977328
168cellular modified amino acid catabolic process (GO:0042219)2.14729484
169regulation of cholesterol homeostasis (GO:2000188)2.13977407
170myeloid cell activation involved in immune response (GO:0002275)2.13579757
171plasma lipoprotein particle remodeling (GO:0034369)2.13116110
172macromolecular complex remodeling (GO:0034367)2.13116110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.13851090
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.56942742
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.46724987
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.45195102
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.19681799
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18703889
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.94313560
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.90538700
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88274870
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.86418865
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84359573
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80195744
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.72773928
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69559473
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60879790
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55522903
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47192512
18CLOCK_20551151_ChIP-Seq_293T_Human2.40007569
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38530169
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31465686
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21035528
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10837912
23VDR_21846776_ChIP-Seq_THP-1_Human2.07974202
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04155368
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94804985
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93221305
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93198237
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82690239
29SPI1_23547873_ChIP-Seq_NB4_Human1.82568468
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75083924
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74154530
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.73167496
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71755785
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71611814
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69739703
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68401210
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62854777
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62376881
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62029819
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.61385597
41MAF_26560356_Chip-Seq_TH1_Human1.60970868
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60580343
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58119921
44GATA1_22025678_ChIP-Seq_K562_Human1.57598402
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57085188
46SCL_19346495_ChIP-Seq_HPC-7_Human1.56429792
47TCF7_22412390_ChIP-Seq_EML_Mouse1.55072881
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52476729
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51193482
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.48751074
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48441319
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48273642
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47881179
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47881179
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.44238754
56MYB_26560356_Chip-Seq_TH2_Human1.43708853
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43403279
58KDM2B_26808549_Chip-Seq_DND41_Human1.41555405
59MYC_22102868_ChIP-Seq_BL_Human1.41103029
60UTX_26944678_Chip-Seq_JUKART_Human1.38889181
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38875505
62VDR_24787735_ChIP-Seq_THP-1_Human1.36670176
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34720089
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33047864
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32747532
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30263329
67SPI1_23127762_ChIP-Seq_K562_Human1.30032890
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28491931
69SOX2_20726797_ChIP-Seq_SW620_Human1.28261141
70RUNX_20019798_ChIP-Seq_JUKART_Human1.28028292
71GATA1_19941826_ChIP-Seq_K562_Human1.27768427
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27641780
73CJUN_26792858_Chip-Seq_BT549_Human1.27607948
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.24140034
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23884140
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23537075
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23439187
78PU_27001747_Chip-Seq_BMDM_Mouse1.22889328
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22740777
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22066260
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.21485817
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21371887
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21129848
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21005037
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20831872
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20630133
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18428104
88MYB_26560356_Chip-Seq_TH1_Human1.17554369
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16320180
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16308358
91LXR_22292898_ChIP-Seq_THP-1_Human1.14935467
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14650453
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13618947
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13581068
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12581464
96GATA2_19941826_ChIP-Seq_K562_Human1.10377133
97MAF_26560356_Chip-Seq_TH2_Human1.09362642
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.09077062
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09022059
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08795647
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08527138
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07094104
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06298175
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05273677
105VDR_24763502_ChIP-Seq_THP-1_Human1.05089830
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04599735
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.04566791
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.02993757
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00294849
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99964709
111GATA3_27048872_Chip-Seq_THYMUS_Human0.98242407
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97786928
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97515891
114* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97302069
115NCOR1_26117541_ChIP-Seq_K562_Human0.96548257
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96118694
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.96027579
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94763715
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94422727
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94390449
121BCOR_27268052_Chip-Seq_Bcells_Human0.93961359
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93822860
123RACK7_27058665_Chip-Seq_MCF-7_Human0.93317577
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93238406
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.92794743
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.92794743
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92694478
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92546057
129* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92306403
130BCL6_27268052_Chip-Seq_Bcells_Human0.91767374
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91299207
132GATA4_25053715_ChIP-Seq_YYC3_Human0.89239812
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.89228403
134KDM2B_26808549_Chip-Seq_K562_Human0.88984658
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88702471
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88702471
137RXR_22108803_ChIP-Seq_LS180_Human0.88597355
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88582251
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88492748
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88307120
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87928609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005058_abnormal_lysosome_morphology4.36600704
2MP0009840_abnormal_foam_cell3.28526466
3MP0008438_abnormal_cutaneous_collagen3.14623548
4MP0003191_abnormal_cellular_cholesterol2.86465850
5* MP0003172_abnormal_lysosome_physiology2.50135800
6MP0005671_abnormal_response_to2.40783645
7MP0003690_abnormal_glial_cell2.37378293
8MP0006082_CNS_inflammation2.30481695
9MP0005360_urolithiasis2.26471676
10MP0003300_gastrointestinal_ulcer2.17970139
11MP0002139_abnormal_hepatobiliary_system2.17702293
12MP0001958_emphysema2.08391411
13MP0003436_decreased_susceptibility_to2.05295276
14MP0001800_abnormal_humoral_immune1.99091211
15MP0003279_aneurysm1.93324905
16MP0002419_abnormal_innate_immunity1.93282224
17MP0003566_abnormal_cell_adhesion1.85370398
18MP0000604_amyloidosis1.82551898
19MP0008875_abnormal_xenobiotic_pharmacok1.79264609
20MP0002420_abnormal_adaptive_immunity1.78939670
21MP0003705_abnormal_hypodermis_morpholog1.78624221
22MP0001819_abnormal_immune_cell1.77567247
23MP0003303_peritoneal_inflammation1.72195764
24MP0000343_altered_response_to1.68468667
25MP0005464_abnormal_platelet_physiology1.67610018
26MP0001533_abnormal_skeleton_physiology1.67048459
27MP0003011_delayed_dark_adaptation1.66511717
28MP0010155_abnormal_intestine_physiology1.64952151
29MP0003075_altered_response_to1.63273716
30MP0009278_abnormal_bone_marrow1.61724283
31MP0003724_increased_susceptibility_to1.61413366
32MP0001835_abnormal_antigen_presentation1.61347875
33MP0005451_abnormal_body_composition1.60568505
34MP0005365_abnormal_bile_salt1.60085083
35MP0004019_abnormal_vitamin_homeostasis1.59301768
36MP0008004_abnormal_stomach_pH1.56096398
37MP0002090_abnormal_vision1.54540804
38MP0002254_reproductive_system_inflammat1.54055041
39MP0010329_abnormal_lipoprotein_level1.52037060
40MP0003828_pulmonary_edema1.50246059
41MP0003252_abnormal_bile_duct1.50130104
42MP0002405_respiratory_system_inflammati1.48410007
43MP0005257_abnormal_intraocular_pressure1.47560940
44MP0002998_abnormal_bone_remodeling1.44974978
45MP0005332_abnormal_amino_acid1.42669106
46MP0001545_abnormal_hematopoietic_system1.42402594
47MP0005397_hematopoietic_system_phenotyp1.42402594
48MP0008260_abnormal_autophagy1.42336267
49MP0003186_abnormal_redox_activity1.41996219
50MP0006054_spinal_hemorrhage1.39668246
51MP0009643_abnormal_urine_homeostasis1.38706599
52MP0003195_calcinosis1.36543509
53MP0005670_abnormal_white_adipose1.35925044
54MP0009764_decreased_sensitivity_to1.33849542
55MP0009333_abnormal_splenocyte_physiolog1.33325325
56MP0002877_abnormal_melanocyte_morpholog1.31922787
57MP0000716_abnormal_immune_system1.30137858
58MP0005167_abnormal_blood-brain_barrier1.27996037
59MP0009384_cardiac_valve_regurgitation1.27170369
60MP0003329_amyloid_beta_deposits1.27076748
61MP0002148_abnormal_hypersensitivity_rea1.26620335
62MP0005275_abnormal_skin_tensile1.26197539
63MP0003656_abnormal_erythrocyte_physiolo1.24487018
64MP0005083_abnormal_biliary_tract1.21566457
65MP0010368_abnormal_lymphatic_system1.21237932
66MP0002398_abnormal_bone_marrow1.21012838
67MP0008469_abnormal_protein_level1.20645607
68MP0005000_abnormal_immune_tolerance1.19980107
69MP0005025_abnormal_response_to1.19844267
70MP0004272_abnormal_basement_membrane1.18299248
71MP0004947_skin_inflammation1.18241879
72MP0002295_abnormal_pulmonary_circulatio1.17575843
73MP0005164_abnormal_response_to1.17339197
74MP0005387_immune_system_phenotype1.16795603
75MP0001790_abnormal_immune_system1.16795603
76MP0005023_abnormal_wound_healing1.15650295
77MP0003950_abnormal_plasma_membrane1.15207907
78MP0005085_abnormal_gallbladder_physiolo1.14525999
79MP0002136_abnormal_kidney_physiology1.12541123
80MP0005166_decreased_susceptibility_to1.11086779
81MP0009785_altered_susceptibility_to1.09324345
82MP0002452_abnormal_antigen_presenting1.07861714
83* MP0000920_abnormal_myelination1.07582925
84MP0002118_abnormal_lipid_homeostasis1.07344711
85MP0005584_abnormal_enzyme/coenzyme_acti1.05900156
86MP0003448_altered_tumor_morphology1.05842649
87MP0000689_abnormal_spleen_morphology1.04835791
88MP0002429_abnormal_blood_cell1.04319136
89MP0000609_abnormal_liver_physiology1.03584726
90MP0001853_heart_inflammation1.02379407
91MP0001756_abnormal_urination1.01945462
92MP0001845_abnormal_inflammatory_respons1.01692626
93MP0002933_joint_inflammation1.00629235
94MP0005319_abnormal_enzyme/_coenzyme1.00472119
95MP0002138_abnormal_hepatobiliary_system1.00212102
96MP0005390_skeleton_phenotype0.98978962
97MP0004130_abnormal_muscle_cell0.97433027
98MP0002722_abnormal_immune_system0.96515823
99MP0000858_altered_metastatic_potential0.96494560
100MP0005310_abnormal_salivary_gland0.95790247
101MP0003763_abnormal_thymus_physiology0.95108271
102MP0000465_gastrointestinal_hemorrhage0.94468376
103MP0004782_abnormal_surfactant_physiolog0.93072992
104MP0000767_abnormal_smooth_muscle0.91890847
105MP0000569_abnormal_digit_pigmentation0.91649000
106MP0005165_increased_susceptibility_to0.91372165
107MP0003183_abnormal_peptide_metabolism0.91316383
108MP0002168_other_aberrant_phenotype0.91157686
109MP0001915_intracranial_hemorrhage0.90643164
110MP0003091_abnormal_cell_migration0.90085133
111MP0004510_myositis0.89298450
112MP0000249_abnormal_blood_vessel0.89032384
113MP0000685_abnormal_immune_system0.88186929
114MP0003453_abnormal_keratinocyte_physiol0.87649133
115MP0003866_abnormal_defecation0.86577237
116MP0009763_increased_sensitivity_to0.86234317
117MP0003045_fibrosis0.86164123
118MP0003806_abnormal_nucleotide_metabolis0.84626452
119MP0001879_abnormal_lymphatic_vessel0.84507167
120MP0001542_abnormal_bone_strength0.84493238
121MP0004883_abnormal_blood_vessel0.83361481
122MP0001851_eye_inflammation0.83140070
123MP0002723_abnormal_immune_serum0.82735086
124MP0003795_abnormal_bone_structure0.81830706
125MP0002135_abnormal_kidney_morphology0.81436784
126MP0000015_abnormal_ear_pigmentation0.76502216
127MP0002166_altered_tumor_susceptibility0.74722268
128MP0005409_darkened_coat_color0.72089270
129MP0001663_abnormal_digestive_system0.70607216
130MP0008874_decreased_physiological_sensi0.69610481
131MP0004808_abnormal_hematopoietic_stem0.67117537
132MP0002132_abnormal_respiratory_system0.64242819
133MP0000371_diluted_coat_color0.59817777

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.44667354
2* Increased cerebral lipofuscin (HP:0011813)5.32097825
3Dysostosis multiplex (HP:0000943)5.04821972
4Systemic lupus erythematosus (HP:0002725)4.78216579
5* Increased neuronal autofluorescent lipopigment (HP:0002074)4.58098905
6Mucopolysacchariduria (HP:0008155)4.30916440
7Urinary glycosaminoglycan excretion (HP:0003541)4.30916440
8Abnormality of polysaccharide metabolism (HP:0011012)4.10835418
9Abnormality of glycosaminoglycan metabolism (HP:0004371)4.10835418
10Abnormality of mucopolysaccharide metabolism (HP:0011020)4.10835418
11Abnormality of glycolipid metabolism (HP:0010969)3.95404669
12Abnormality of liposaccharide metabolism (HP:0010968)3.95404669
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.95404669
14Axonal loss (HP:0003447)3.64310577
15Abnormality of macrophages (HP:0004311)3.60500154
16Complement deficiency (HP:0004431)3.46319498
17Recurrent gram-negative bacterial infections (HP:0005420)3.42741183
18Recurrent abscess formation (HP:0002722)3.40631399
19Glomerulonephritis (HP:0000099)3.38466460
20Myositis (HP:0100614)3.32244599
21Loss of speech (HP:0002371)3.19317083
22Recurrent bacterial skin infections (HP:0005406)3.17422354
23Prolonged bleeding time (HP:0003010)3.12987784
24Eczematoid dermatitis (HP:0000976)3.10905910
25Orchitis (HP:0100796)3.06716749
26Epistaxis (HP:0000421)3.02884374
27Xanthomatosis (HP:0000991)2.96185669
28Myocardial infarction (HP:0001658)2.94522393
29Elevated erythrocyte sedimentation rate (HP:0003565)2.84015759
30Interstitial pulmonary disease (HP:0006530)2.82493961
31Premature rupture of membranes (HP:0001788)2.81412794
32Neurofibrillary tangles (HP:0002185)2.80854957
33Obstructive lung disease (HP:0006536)2.80065966
34Chronic obstructive pulmonary disease (HP:0006510)2.80065966
35Abnormality of complement system (HP:0005339)2.77628547
36Retrobulbar optic neuritis (HP:0100654)2.74741983
37Optic neuritis (HP:0100653)2.74741983
38Cervical subluxation (HP:0003308)2.70989874
39Stomatitis (HP:0010280)2.70268437
40Autoimmune thrombocytopenia (HP:0001973)2.63701557
41Spondylolisthesis (HP:0003302)2.62245011
42* Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60461565
43Mediastinal lymphadenopathy (HP:0100721)2.58435722
44Mutism (HP:0002300)2.52891771
45Nephritis (HP:0000123)2.46561917
46Retinal atrophy (HP:0001105)2.45000358
47Asymmetric septal hypertrophy (HP:0001670)2.43736157
48Cerebral aneurysm (HP:0004944)2.42256961
49Tetraparesis (HP:0002273)2.41793806
50Pulmonary infiltrates (HP:0002113)2.41530238
51Ovoid vertebral bodies (HP:0003300)2.40344658
52Vasculitis (HP:0002633)2.38872796
53Meningitis (HP:0001287)2.37695662
54Hyperlipoproteinemia (HP:0010980)2.35878838
55Protrusio acetabuli (HP:0003179)2.33289943
56Deep venous thrombosis (HP:0002625)2.32440209
57Aortic aneurysm (HP:0004942)2.32128391
58Vertebral compression fractures (HP:0002953)2.31085182
59Hydroxyprolinuria (HP:0003080)2.27224571
60Abnormality of proline metabolism (HP:0010907)2.27224571
61Abnormality of the lumbar spine (HP:0100712)2.26713313
62Joint hemorrhage (HP:0005261)2.26425912
63Vascular calcification (HP:0004934)2.25606588
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25458919
65Recurrent fungal infections (HP:0002841)2.25366623
66Nuclear cataract (HP:0100018)2.24483130
67Pathologic fracture (HP:0002756)2.23420147
68Aortic dissection (HP:0002647)2.22561679
69Arterial tortuosity (HP:0005116)2.21884234
70Cardiovascular calcification (HP:0011915)2.21338049
71Vascular tortuosity (HP:0004948)2.21138404
72Purpura (HP:0000979)2.20375155
73Mitral stenosis (HP:0001718)2.17034878
74Polycythemia (HP:0001901)2.13915641
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13271169
76Menorrhagia (HP:0000132)2.09931667
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.09921402
78Osteolytic defects of the hand bones (HP:0009699)2.09921402
79Cellulitis (HP:0100658)2.09056334
80Hemoptysis (HP:0002105)2.08821180
81Thoracic kyphosis (HP:0002942)2.08761319
82Hepatosplenomegaly (HP:0001433)2.08710585
83Gastrointestinal infarctions (HP:0005244)2.06937208
84Hypercholesterolemia (HP:0003124)2.06516320
85Increased IgE level (HP:0003212)2.05752700
86Pulmonary embolism (HP:0002204)2.04801876
87Diminished motivation (HP:0000745)2.04151925
88Abnormality of iron homeostasis (HP:0011031)2.04117271
89Chest pain (HP:0100749)2.03844828
90Arterial thrombosis (HP:0004420)2.03023803
91Apathy (HP:0000741)2.02557349
92Hypoalphalipoproteinemia (HP:0003233)2.00042785
93Cerebral inclusion bodies (HP:0100314)1.99995112
94Gingival bleeding (HP:0000225)1.99917111
95Amyloidosis (HP:0011034)1.99772479
96Esophageal varix (HP:0002040)1.98971465
97Disinhibition (HP:0000734)1.98584131
98Recurrent cutaneous fungal infections (HP:0011370)1.98092585
99Chronic mucocutaneous candidiasis (HP:0002728)1.98092585
100Supranuclear gaze palsy (HP:0000605)1.97644956
101Abnormal platelet volume (HP:0011876)1.96977292
102Peritonitis (HP:0002586)1.96968740
103Keratoconjunctivitis sicca (HP:0001097)1.95744772
104Recurrent viral infections (HP:0004429)1.95165666
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93987611
106Protuberant abdomen (HP:0001538)1.93858848
107Beaking of vertebral bodies (HP:0004568)1.93843964
108Petechiae (HP:0000967)1.91651249
109* Progressive visual loss (HP:0000529)1.89930388
110Recurrent skin infections (HP:0001581)1.89832534
111Encephalitis (HP:0002383)1.89670755
112Gingivitis (HP:0000230)1.89420066
113Episodic fever (HP:0001954)1.89231317
114Prolonged neonatal jaundice (HP:0006579)1.87878427
115Broad metatarsal (HP:0001783)1.87554521
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.87538344
117Restrictive lung disease (HP:0002091)1.87298760
118Increased CSF protein (HP:0002922)1.86715788
119Nausea (HP:0002018)1.85727945
120Osteomyelitis (HP:0002754)1.83235781
121Progressive neurologic deterioration (HP:0002344)1.81301043
122Hypergammaglobulinemia (HP:0010702)1.80904074
123Sensorimotor neuropathy (HP:0007141)1.80554948
124Pustule (HP:0200039)1.80304265
125Neuronal loss in central nervous system (HP:0002529)1.79282500
126Disproportionate tall stature (HP:0001519)1.78724641
127Urticaria (HP:0001025)1.77557260
128Abnormality of fatty-acid metabolism (HP:0004359)1.77507205
129Thrombocytosis (HP:0001894)1.76918583
130Inflammation of the large intestine (HP:0002037)1.76013567
131J-shaped sella turcica (HP:0002680)1.75894797
132Peripheral demyelination (HP:0011096)1.73737773
133Hematochezia (HP:0002573)1.73522922
134Conjunctival telangiectasia (HP:0000524)1.73125830
135Bone pain (HP:0002653)1.72845882
136Increased serum ferritin (HP:0003281)1.71084063
137Nonimmune hydrops fetalis (HP:0001790)1.70924488
138Spontaneous hematomas (HP:0007420)1.67377723
139Blue sclerae (HP:0000592)1.66455175
140Skin nodule (HP:0200036)1.66269309
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65796305
142Joint stiffness (HP:0001387)1.65401247
143Abnormal platelet function (HP:0011869)1.64961132
144Impaired platelet aggregation (HP:0003540)1.64961132
145Global brain atrophy (HP:0002283)1.64590508
146Intrahepatic cholestasis (HP:0001406)1.63411309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.03827318
2TGFBR23.41488734
3TRIB33.15078608
4SIK13.05948695
5PRPF4B2.75293746
6EPHB12.60162945
7TAOK32.51963858
8CAMK1D2.25505855
9TYK22.22262176
10KIT2.20650960
11TBK12.09671994
12RIPK12.02223564
13NEK91.95734062
14BLK1.93835912
15IRAK31.88605642
16MAP2K31.80634172
17JAK11.71751856
18CAMK1G1.70203353
19PTK61.68487582
20LRRK21.67313369
21BMPR21.60992979
22MAP3K141.54501683
23PAK41.52049640
24TTN1.51322458
25TAOK21.49273840
26PKN21.44770799
27FGFR41.43637158
28FGR1.43169651
29TESK21.40930193
30STK101.37325488
31TXK1.34776777
32IRAK41.34388282
33MAP3K111.34380241
34GRK71.32233194
35MAP4K11.29683200
36CDC42BPA1.26471847
37PIM21.24956480
38MAP3K11.21269820
39KDR1.18112247
40CSF1R1.16357779
41TNK21.15364592
42MAP3K31.13834937
43BMX1.13509302
44MST1R1.12986078
45PBK1.10960676
46BCKDK1.08211762
47CSK1.07994467
48TRPM71.07545859
49TAOK11.04705724
50ZAP701.03425659
51DDR21.03396837
52CDK61.02700304
53NME21.01328662
54GRK61.00479247
55JAK20.98391135
56PTK20.91907078
57IKBKB0.91319383
58JAK30.91225409
59TESK10.90457146
60HCK0.90299485
61IKBKE0.89710118
62ITK0.88880649
63BTK0.84890274
64PDK10.84650871
65MAP3K130.84281743
66RPS6KA40.82721161
67MAPK120.78013176
68KSR20.77949460
69MET0.77862654
70PIK3CG0.77026813
71HIPK20.76367805
72SGK30.75808620
73TIE10.73612907
74PDGFRA0.72662533
75LYN0.72252558
76IRAK20.70848559
77EGFR0.70484954
78WNK40.69447525
79ABL20.69270380
80EPHA30.68971891
81MARK30.67614344
82DYRK1B0.66364317
83PAK20.66176586
84ICK0.65728080
85SCYL20.64395861
86ARAF0.64293487
87RIPK40.64036772
88MARK20.62830403
89PRKD20.61877566
90IGF1R0.61409492
91MAP3K20.60935330
92DMPK0.60548305
93SIK30.59084369
94LCK0.57895005
95SIK20.57690683
96FGFR30.56849625
97CHUK0.55980551
98FES0.55254028
99GSK3A0.55062015
100ABL10.54865119
101MATK0.53955053
102YES10.53759967
103MAPK70.53571741
104GRK10.52569712
105MAP3K70.52510139
106SRC0.52298720
107PRKCD0.52203047
108OXSR10.51543250
109PDGFRB0.51355368
110PRKAA20.49797387
111TEC0.49782973
112EPHB20.49274068
113SYK0.47773952
114DAPK20.47644555
115PTK2B0.47233670
116PRKG20.46662525
117CDK120.46496684
118IRAK10.45635968
119MOS0.44828988
120CAMKK20.44662970
121RPS6KA20.44580809
122PDPK10.44389265
123RPS6KC10.43206041
124RPS6KL10.43206041
125MAP3K50.42631137
126MYLK0.42625711
127MAPKAPK20.42491722
128FYN0.41918645
129PRKCH0.41757809
130MST40.40923360
131MAP2K60.40839110
132MAPK110.40654647
133PRKD10.39739278
134FGFR10.38929186
135MAP3K60.38736051
136RET0.37460385

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.37198360
2* Lysosome_Homo sapiens_hsa041423.36535924
3Staphylococcus aureus infection_Homo sapiens_hsa051503.21664796
4Nitrogen metabolism_Homo sapiens_hsa009103.08239016
5Other glycan degradation_Homo sapiens_hsa005112.83295585
6Allograft rejection_Homo sapiens_hsa053302.50966452
7Asthma_Homo sapiens_hsa053102.49634791
8Graft-versus-host disease_Homo sapiens_hsa053322.36830529
9Complement and coagulation cascades_Homo sapiens_hsa046102.36320104
10Autoimmune thyroid disease_Homo sapiens_hsa053202.22333498
11Fatty acid degradation_Homo sapiens_hsa000711.95787113
12Type I diabetes mellitus_Homo sapiens_hsa049401.90856077
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.89961820
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79863846
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65390751
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.64807130
17PPAR signaling pathway_Homo sapiens_hsa033201.61390956
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61257133
19Fatty acid metabolism_Homo sapiens_hsa012121.58417608
20Malaria_Homo sapiens_hsa051441.57300176
21Caffeine metabolism_Homo sapiens_hsa002321.53997777
22Viral myocarditis_Homo sapiens_hsa054161.49507410
23Leishmaniasis_Homo sapiens_hsa051401.48982125
24Steroid biosynthesis_Homo sapiens_hsa001001.44304335
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43086994
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40989100
27Peroxisome_Homo sapiens_hsa041461.36853505
28Phagosome_Homo sapiens_hsa041451.36743092
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33304616
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28928732
31Arginine biosynthesis_Homo sapiens_hsa002201.28690103
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27868409
33Osteoclast differentiation_Homo sapiens_hsa043801.27020426
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26394511
35Influenza A_Homo sapiens_hsa051641.26025363
36Histidine metabolism_Homo sapiens_hsa003401.23937507
37Tuberculosis_Homo sapiens_hsa051521.19536307
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14960257
39Pertussis_Homo sapiens_hsa051331.12813564
40Acute myeloid leukemia_Homo sapiens_hsa052211.12248378
41Tryptophan metabolism_Homo sapiens_hsa003801.10725726
42Chemokine signaling pathway_Homo sapiens_hsa040621.08161911
43ECM-receptor interaction_Homo sapiens_hsa045121.07007061
44Rheumatoid arthritis_Homo sapiens_hsa053231.06575855
45Bile secretion_Homo sapiens_hsa049761.06050458
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04148731
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03554071
48Propanoate metabolism_Homo sapiens_hsa006401.02774743
49Chemical carcinogenesis_Homo sapiens_hsa052041.02243457
50Starch and sucrose metabolism_Homo sapiens_hsa005000.99638054
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97238643
52Sphingolipid metabolism_Homo sapiens_hsa006000.96658109
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96638294
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96385708
55African trypanosomiasis_Homo sapiens_hsa051430.93743834
56Herpes simplex infection_Homo sapiens_hsa051680.92853555
57ABC transporters_Homo sapiens_hsa020100.92135831
58Vitamin digestion and absorption_Homo sapiens_hsa049770.91408310
59beta-Alanine metabolism_Homo sapiens_hsa004100.91080751
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90729607
61Primary immunodeficiency_Homo sapiens_hsa053400.88780786
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88379681
63Legionellosis_Homo sapiens_hsa051340.88004615
64T cell receptor signaling pathway_Homo sapiens_hsa046600.85904853
65Fatty acid elongation_Homo sapiens_hsa000620.85246701
66Shigellosis_Homo sapiens_hsa051310.83772460
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.83066334
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82866365
69Amoebiasis_Homo sapiens_hsa051460.82446730
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81942264
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.80472588
72Mineral absorption_Homo sapiens_hsa049780.78944067
73Renin-angiotensin system_Homo sapiens_hsa046140.78487553
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75139633
75Toxoplasmosis_Homo sapiens_hsa051450.74601081
76Hepatitis B_Homo sapiens_hsa051610.74312167
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74030970
78Galactose metabolism_Homo sapiens_hsa000520.73066435
79Carbon metabolism_Homo sapiens_hsa012000.73064311
80Collecting duct acid secretion_Homo sapiens_hsa049660.72301313
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71133383
82VEGF signaling pathway_Homo sapiens_hsa043700.69069081
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68129336
84Lysine degradation_Homo sapiens_hsa003100.67000868
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66734634
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66503442
87Pentose phosphate pathway_Homo sapiens_hsa000300.66288192
88Chronic myeloid leukemia_Homo sapiens_hsa052200.65123207
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.65035644
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.62100083
91Fatty acid biosynthesis_Homo sapiens_hsa000610.61893996
92Proteoglycans in cancer_Homo sapiens_hsa052050.61748581
93Prion diseases_Homo sapiens_hsa050200.61171255
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60647490
95Glutathione metabolism_Homo sapiens_hsa004800.60474664
96Bladder cancer_Homo sapiens_hsa052190.60341818
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59894371
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.59552235
99Focal adhesion_Homo sapiens_hsa045100.58749667
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58468892
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58286216
102Non-small cell lung cancer_Homo sapiens_hsa052230.57969868
103Glycerolipid metabolism_Homo sapiens_hsa005610.57935238
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.57392703
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.57129404
106Retinol metabolism_Homo sapiens_hsa008300.56985781
107Antigen processing and presentation_Homo sapiens_hsa046120.55969572
108Sulfur metabolism_Homo sapiens_hsa009200.55437035
109Hematopoietic cell lineage_Homo sapiens_hsa046400.55369380
110Phenylalanine metabolism_Homo sapiens_hsa003600.54702646
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54159180
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52507131
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52196483
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51746819
115Vibrio cholerae infection_Homo sapiens_hsa051100.51705664
116Apoptosis_Homo sapiens_hsa042100.51649439
117Prolactin signaling pathway_Homo sapiens_hsa049170.50559795
118Arginine and proline metabolism_Homo sapiens_hsa003300.50295412
119Biosynthesis of amino acids_Homo sapiens_hsa012300.49321980
120Butanoate metabolism_Homo sapiens_hsa006500.49210794
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.48727806
122TNF signaling pathway_Homo sapiens_hsa046680.48520623
123B cell receptor signaling pathway_Homo sapiens_hsa046620.48339776
124Renal cell carcinoma_Homo sapiens_hsa052110.48171564
125Fructose and mannose metabolism_Homo sapiens_hsa000510.47683080
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47665417
127Tyrosine metabolism_Homo sapiens_hsa003500.46846833
128Insulin resistance_Homo sapiens_hsa049310.46813881
129Salmonella infection_Homo sapiens_hsa051320.46447413
130Pyruvate metabolism_Homo sapiens_hsa006200.45097739
131Notch signaling pathway_Homo sapiens_hsa043300.44387069
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44111103
133Measles_Homo sapiens_hsa051620.43926552
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43916053
135Hepatitis C_Homo sapiens_hsa051600.43420568
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42903694
137Platelet activation_Homo sapiens_hsa046110.42138283
138Pancreatic cancer_Homo sapiens_hsa052120.40782477
139Endocytosis_Homo sapiens_hsa041440.40739421
140GnRH signaling pathway_Homo sapiens_hsa049120.39978936
141Protein digestion and absorption_Homo sapiens_hsa049740.38559379
142HIF-1 signaling pathway_Homo sapiens_hsa040660.38330040
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32808708
144Type II diabetes mellitus_Homo sapiens_hsa049300.32485706
145HTLV-I infection_Homo sapiens_hsa051660.29826492
146Choline metabolism in cancer_Homo sapiens_hsa052310.28491624
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28121406
148Epstein-Barr virus infection_Homo sapiens_hsa051690.27482697
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27428230
150Dorso-ventral axis formation_Homo sapiens_hsa043200.26941313

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