TPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.16261223
2nuclear pore organization (GO:0006999)5.77069814
3pore complex assembly (GO:0046931)4.85794131
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.70447844
5mitotic sister chromatid cohesion (GO:0007064)4.39790459
6positive regulation of granulocyte differentiation (GO:0030854)3.92533740
7regulation of B cell receptor signaling pathway (GO:0050855)3.73863390
8meiotic chromosome segregation (GO:0045132)3.62942609
9positive regulation of B cell differentiation (GO:0045579)3.61476237
10regulation of DNA endoreduplication (GO:0032875)3.50370416
11negative T cell selection (GO:0043383)3.50173460
12positive regulation of mitotic sister chromatid separation (GO:1901970)3.47660824
13positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47660824
14positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47660824
15mitotic nuclear envelope disassembly (GO:0007077)3.46105621
16V(D)J recombination (GO:0033151)3.43205970
17positive regulation of histone H3-K4 methylation (GO:0051571)3.35459274
18negative thymic T cell selection (GO:0045060)3.35172755
19kinetochore organization (GO:0051383)3.34827793
20regulation of centriole replication (GO:0046599)3.28833441
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27744259
22non-recombinational repair (GO:0000726)3.27149025
23double-strand break repair via nonhomologous end joining (GO:0006303)3.27149025
24membrane disassembly (GO:0030397)3.25414212
25nuclear envelope disassembly (GO:0051081)3.25414212
26regulation of histone H3-K9 methylation (GO:0051570)3.18950173
27somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.18488455
28somatic cell DNA recombination (GO:0016444)3.18488455
29negative regulation of DNA repair (GO:0045738)3.17358991
30positive T cell selection (GO:0043368)3.14830222
31DNA unwinding involved in DNA replication (GO:0006268)3.14776013
32somatic recombination of immunoglobulin gene segments (GO:0016447)3.14290049
33monoubiquitinated protein deubiquitination (GO:0035520)3.11369094
34histone H3-K36 demethylation (GO:0070544)3.05269798
35mitotic G2 DNA damage checkpoint (GO:0007095)3.03851265
36rRNA catabolic process (GO:0016075)3.03507395
37DNA strand elongation involved in DNA replication (GO:0006271)3.02938390
38regulation of B cell differentiation (GO:0045577)3.02748989
39somatic diversification of immune receptors (GO:0002200)3.02326753
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00576151
41somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97146352
42isotype switching (GO:0045190)2.97146352
43somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97146352
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95421034
45B cell receptor signaling pathway (GO:0050853)2.94801629
46somatic diversification of immunoglobulins (GO:0016445)2.92396739
47sister chromatid segregation (GO:0000819)2.92371266
48chromatin remodeling at centromere (GO:0031055)2.91007895
49regulation of gamma-delta T cell differentiation (GO:0045586)2.90145398
50protein localization to kinetochore (GO:0034501)2.89590333
51positive thymic T cell selection (GO:0045059)2.88917028
52mitotic chromosome condensation (GO:0007076)2.86621018
53DNA geometric change (GO:0032392)2.86235292
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.85609098
55CENP-A containing nucleosome assembly (GO:0034080)2.84508213
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84413079
57IMP biosynthetic process (GO:0006188)2.83448471
58sister chromatid cohesion (GO:0007062)2.83245197
59DNA strand elongation (GO:0022616)2.82039577
60DNA duplex unwinding (GO:0032508)2.81460527
61telomere maintenance via semi-conservative replication (GO:0032201)2.80929990
62DNA double-strand break processing (GO:0000729)2.80806491
63ribosome assembly (GO:0042255)2.79877434
64T cell migration (GO:0072678)2.79811931
65regulation of RNA export from nucleus (GO:0046831)2.79142599
66regulation of spindle organization (GO:0090224)2.78308271
67translesion synthesis (GO:0019985)2.78018289
68positive regulation of histone methylation (GO:0031062)2.77052409
69negative regulation of DNA-dependent DNA replication (GO:2000104)2.75582683
70pre-miRNA processing (GO:0031054)2.75249113
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73453065
72establishment of chromosome localization (GO:0051303)2.72576355
73regulation of alpha-beta T cell proliferation (GO:0046640)2.72017017
74double-strand break repair via homologous recombination (GO:0000724)2.68980154
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68167370
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.68167370
77protein localization to chromosome, centromeric region (GO:0071459)2.67418976
78negative regulation of B cell proliferation (GO:0030889)2.66842096
79positive regulation of chromosome segregation (GO:0051984)2.64871055
80DNA ligation (GO:0006266)2.63909643
81histone exchange (GO:0043486)2.63566490
82recombinational repair (GO:0000725)2.63395915
83DNA replication-independent nucleosome organization (GO:0034724)2.62910473
84DNA replication-independent nucleosome assembly (GO:0006336)2.62910473
85regulation of centrosome cycle (GO:0046605)2.62793720
86attachment of spindle microtubules to kinetochore (GO:0008608)2.62777190
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62499703
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62499703
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.62499703
90negative regulation of sister chromatid segregation (GO:0033046)2.62499703
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62499703
92DNA replication-dependent nucleosome assembly (GO:0006335)2.61904446
93DNA replication-dependent nucleosome organization (GO:0034723)2.61904446
94negative regulation of chromosome segregation (GO:0051985)2.61390608
95regulation of centrosome duplication (GO:0010824)2.61380010
96response to X-ray (GO:0010165)2.60219003
97replication fork processing (GO:0031297)2.58353823
98metaphase plate congression (GO:0051310)2.58099723
99DNA topological change (GO:0006265)2.56897374
100regulation of gamma-delta T cell activation (GO:0046643)2.56620781
101synapsis (GO:0007129)2.56439889
102nucleobase biosynthetic process (GO:0046112)2.55786013
103negative regulation of DNA recombination (GO:0045910)2.55331307
104protein K6-linked ubiquitination (GO:0085020)2.55147418
105mitotic sister chromatid segregation (GO:0000070)2.54862955
106mitotic recombination (GO:0006312)2.54627947
107regulation of helicase activity (GO:0051095)2.54591829
108mitotic spindle checkpoint (GO:0071174)2.54005825
109IMP metabolic process (GO:0046040)2.53558547
110mitotic spindle assembly checkpoint (GO:0007094)2.52186443
111dosage compensation (GO:0007549)2.52150183
112response to interleukin-15 (GO:0070672)2.52005109
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50792085
114regulation of mitotic spindle checkpoint (GO:1903504)2.50792085
115regulation of protein polyubiquitination (GO:1902914)2.50512981
116DNA conformation change (GO:0071103)2.48727755
117chromatin assembly (GO:0031497)2.48710977
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47889575
119postreplication repair (GO:0006301)2.47629643
120hepatocyte apoptotic process (GO:0097284)2.46038966
121DNA replication initiation (GO:0006270)2.45859513
122regulation of mitotic spindle organization (GO:0060236)2.45084897
123nuclear envelope organization (GO:0006998)2.43112522
124positive regulation of protein import into nucleus, translocation (GO:0033160)2.42102649
125negative regulation of histone methylation (GO:0031061)2.41296342
126gene silencing by RNA (GO:0031047)2.41198019
127heterochromatin organization (GO:0070828)2.40834297
128piRNA metabolic process (GO:0034587)2.39518738
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.39309409
130histone mRNA catabolic process (GO:0071044)2.37739979
131chromosome segregation (GO:0007059)2.36419391
132DNA synthesis involved in DNA repair (GO:0000731)2.35529343
133mitotic metaphase plate congression (GO:0007080)2.33718561
134regulation of mitotic sister chromatid separation (GO:0010965)2.33485192
135regulation of mitotic sister chromatid segregation (GO:0033047)2.33485192
136regulation of sister chromatid segregation (GO:0033045)2.33485192
137kinetochore assembly (GO:0051382)2.33249373
138telomere maintenance (GO:0000723)2.33138287
139mRNA transport (GO:0051028)2.33095471
140telomere maintenance via recombination (GO:0000722)2.32781766
141spindle checkpoint (GO:0031577)2.29686181
142positive regulation of gamma-delta T cell activation (GO:0046645)2.29245521
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.28767053
144viral mRNA export from host cell nucleus (GO:0046784)2.28660502
145mitotic G2/M transition checkpoint (GO:0044818)2.28498365
146telomere organization (GO:0032200)2.27871944
147definitive hemopoiesis (GO:0060216)2.27782823
148acrosome assembly (GO:0001675)2.27108581
149chromosome organization involved in meiosis (GO:0070192)2.26979997
150DNA strand renaturation (GO:0000733)2.26717288
151regulation of double-strand break repair (GO:2000779)2.26617179
152nucleus organization (GO:0006997)2.26262159
153regulation of chromosome segregation (GO:0051983)2.25801434
154DNA packaging (GO:0006323)2.24756532
155protein localization to chromosome (GO:0034502)2.24712034
156ATP-dependent chromatin remodeling (GO:0043044)2.23832698
157regulation of nucleobase-containing compound transport (GO:0032239)2.22543134
158negative regulation of phagocytosis (GO:0050765)2.22087883
159RNA stabilization (GO:0043489)2.21530909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.33788986
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04994054
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.02848525
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.86083864
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64237132
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05375484
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88145755
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82966378
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59160260
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55561349
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46653450
12* ELK1_19687146_ChIP-ChIP_HELA_Human2.34294318
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.18332936
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17871961
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.13765259
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.10452610
17* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05256779
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01962351
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01516352
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.98598464
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95306766
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91274692
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85821533
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85463100
25AR_21909140_ChIP-Seq_LNCAP_Human1.73209793
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68592553
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58396148
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57708867
29* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55381792
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54690231
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53895089
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.53726370
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51561118
34IGF1R_20145208_ChIP-Seq_DFB_Human1.48015104
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46732839
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45983800
37VDR_23849224_ChIP-Seq_CD4+_Human1.44359608
38* MYB_26560356_Chip-Seq_TH2_Human1.43339202
39GATA3_27048872_Chip-Seq_THYMUS_Human1.42031568
40FUS_26573619_Chip-Seq_HEK293_Human1.41618980
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40092968
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.40077351
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37041431
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34924477
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34840223
46* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33878175
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.33509041
48GATA3_26560356_Chip-Seq_TH2_Human1.33345039
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32389755
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30379361
51* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30110416
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29480630
53* MYB_26560356_Chip-Seq_TH1_Human1.29304599
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28484043
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28457050
56* FLI1_27457419_Chip-Seq_LIVER_Mouse1.27962686
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26696003
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.24380949
59* SPI1_23547873_ChIP-Seq_NB4_Human1.23109444
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23034932
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20396521
62BRD4_25478319_ChIP-Seq_HGPS_Human1.13312361
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12551272
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11876117
65* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11820527
66* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11318720
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.11285566
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10785260
69* FOXP3_21729870_ChIP-Seq_TREG_Human1.10655562
70TFEB_21752829_ChIP-Seq_HELA_Human1.09934146
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09815818
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09815818
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.07846893
74MYC_22102868_ChIP-Seq_BL_Human1.05082022
75* EZH2_27294783_Chip-Seq_NPCs_Mouse1.03593590
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02580825
77EWS_26573619_Chip-Seq_HEK293_Human1.00845725
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00206524
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99305655
80* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97950694
81* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96759421
82* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96494535
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95864989
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95296657
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94307951
86RUNX_20019798_ChIP-Seq_JUKART_Human0.94267791
87* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94168583
88HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93546976
89* PU_27001747_Chip-Seq_BMDM_Mouse0.93529642
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93258582
91* RUNX1_22412390_ChIP-Seq_EML_Mouse0.92945378
92* NFE2_27457419_Chip-Seq_LIVER_Mouse0.92756812
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92671176
94* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92653713
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92436630
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92365391
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92110613
98MYC_18940864_ChIP-ChIP_HL60_Human0.91795823
99DCP1A_22483619_ChIP-Seq_HELA_Human0.91284743
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90982833
101* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90305256
102SALL4_22934838_ChIP-ChIP_CD34+_Human0.89651691
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.89593560
104ETS1_20019798_ChIP-Seq_JURKAT_Human0.89441538
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87685795
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85967164
107* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84755830
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.84346526
109CIITA_25753668_ChIP-Seq_RAJI_Human0.84305618
110GATA3_26560356_Chip-Seq_TH1_Human0.84054559
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.83964223
112MAF_26560356_Chip-Seq_TH1_Human0.83948911
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83578604
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83518486
115IRF1_19129219_ChIP-ChIP_H3396_Human0.83014205
116* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82673427
117* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82315953
118SCL_19346495_ChIP-Seq_HPC-7_Human0.81621346
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81419137
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81220472
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80759539
122ER_23166858_ChIP-Seq_MCF-7_Human0.80738266
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80228958
124XRN2_22483619_ChIP-Seq_HELA_Human0.77980368
125GATA1_22025678_ChIP-Seq_K562_Human0.77647827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.26489609
2MP0010352_gastrointestinal_tract_polyps3.05211427
3MP0010094_abnormal_chromosome_stability2.96285537
4MP0008877_abnormal_DNA_methylation2.77019155
5MP0003693_abnormal_embryo_hatching2.47469156
6MP0000569_abnormal_digit_pigmentation2.43145150
7* MP0003077_abnormal_cell_cycle2.30816857
8MP0003111_abnormal_nucleus_morphology2.29003355
9* MP0008007_abnormal_cellular_replicative2.27592486
10MP0003646_muscle_fatigue2.20991049
11MP0010307_abnormal_tumor_latency2.17037763
12MP0008058_abnormal_DNA_repair2.12257728
13MP0002877_abnormal_melanocyte_morpholog2.05860485
14MP0002396_abnormal_hematopoietic_system2.05478526
15* MP0001835_abnormal_antigen_presentation2.02598511
16MP0004957_abnormal_blastocyst_morpholog2.02234003
17MP0004808_abnormal_hematopoietic_stem1.97649024
18MP0005464_abnormal_platelet_physiology1.85212829
19MP0003123_paternal_imprinting1.82410180
20MP0002166_altered_tumor_susceptibility1.77077996
21MP0003763_abnormal_thymus_physiology1.69784841
22MP0002006_tumorigenesis1.65403767
23MP0005076_abnormal_cell_differentiation1.65138634
24MP0006054_spinal_hemorrhage1.62382514
25MP0008438_abnormal_cutaneous_collagen1.56981739
26MP0001545_abnormal_hematopoietic_system1.53656417
27MP0005397_hematopoietic_system_phenotyp1.53656417
28MP0009697_abnormal_copulation1.53467925
29MP0003121_genomic_imprinting1.51325579
30MP0005075_abnormal_melanosome_morpholog1.48761442
31MP0003787_abnormal_imprinting1.48692576
32MP0001661_extended_life_span1.46739787
33MP0003279_aneurysm1.45481431
34MP0003943_abnormal_hepatobiliary_system1.43111479
35MP0003705_abnormal_hypodermis_morpholog1.39523437
36MP0002009_preneoplasia1.38873086
37MP0005503_abnormal_tendon_morphology1.37546564
38MP0005671_abnormal_response_to1.36836531
39MP0000350_abnormal_cell_proliferation1.36266800
40MP0001800_abnormal_humoral_immune1.34297189
41* MP0002398_abnormal_bone_marrow1.32412458
42MP0002452_abnormal_antigen_presenting1.31931943
43MP0003566_abnormal_cell_adhesion1.30776000
44* MP0003786_premature_aging1.29260589
45MP0003984_embryonic_growth_retardation1.28999354
46MP0002088_abnormal_embryonic_growth/wei1.27176532
47MP0002086_abnormal_extraembryonic_tissu1.26367898
48MP0004185_abnormal_adipocyte_glucose1.25714511
49MP0001672_abnormal_embryogenesis/_devel1.25311907
50MP0005380_embryogenesis_phenotype1.25311907
51MP0004197_abnormal_fetal_growth/weight/1.25058360
52MP0008932_abnormal_embryonic_tissue1.24394226
53MP0001730_embryonic_growth_arrest1.23869345
54MP0000516_abnormal_urinary_system1.21892039
55MP0005367_renal/urinary_system_phenotyp1.21892039
56MP0003436_decreased_susceptibility_to1.21493235
57MP0009333_abnormal_splenocyte_physiolog1.21406123
58MP0000465_gastrointestinal_hemorrhage1.21346011
59MP0003300_gastrointestinal_ulcer1.18055886
60* MP0000703_abnormal_thymus_morphology1.17446877
61MP0003567_abnormal_fetal_cardiomyocyte1.17104527
62MP0005000_abnormal_immune_tolerance1.16865132
63* MP0002420_abnormal_adaptive_immunity1.15769334
64* MP0001819_abnormal_immune_cell1.14449348
65MP0000490_abnormal_crypts_of1.14046383
66MP0003448_altered_tumor_morphology1.13883387
67MP0005023_abnormal_wound_healing1.11234992
68MP0001915_intracranial_hemorrhage1.10529998
69MP0002723_abnormal_immune_serum1.09954219
70MP0002405_respiratory_system_inflammati1.07323567
71MP0001853_heart_inflammation1.05930906
72MP0001697_abnormal_embryo_size1.05891617
73MP0002419_abnormal_innate_immunity1.05263132
74MP0003890_abnormal_embryonic-extraembry1.05110020
75* MP0000689_abnormal_spleen_morphology1.04364143
76MP0003656_abnormal_erythrocyte_physiolo1.02486580
77MP0002210_abnormal_sex_determination1.01823581
78MP0002148_abnormal_hypersensitivity_rea1.01275833
79MP0005623_abnormal_meninges_morphology1.00352307
80MP0009053_abnormal_anal_canal1.00204551
81* MP0002722_abnormal_immune_system0.99070836
82MP0006035_abnormal_mitochondrial_morpho0.99036702
83* MP0000716_abnormal_immune_system0.98720109
84MP0002019_abnormal_tumor_incidence0.97472283
85MP0000733_abnormal_muscle_development0.96293420
86MP0009278_abnormal_bone_marrow0.96227005
87MP0000858_altered_metastatic_potential0.96209288
88MP0001873_stomach_inflammation0.96089920
89MP0003828_pulmonary_edema0.95284198
90MP0009785_altered_susceptibility_to0.93750238
91* MP0002429_abnormal_blood_cell0.93518535
92MP0001929_abnormal_gametogenesis0.93024357
93MP0003221_abnormal_cardiomyocyte_apopto0.92523934
94MP0002933_joint_inflammation0.92408628
95MP0002084_abnormal_developmental_patter0.91743835
96MP0003091_abnormal_cell_migration0.91337801
97MP0000313_abnormal_cell_death0.90880210
98MP0005645_abnormal_hypothalamus_physiol0.90672921
99MP0002837_dystrophic_cardiac_calcinosis0.88840844
100MP0002138_abnormal_hepatobiliary_system0.88792790
101MP0000015_abnormal_ear_pigmentation0.88204183
102MP0005310_abnormal_salivary_gland0.87394294
103MP0002080_prenatal_lethality0.86399968
104MP0010155_abnormal_intestine_physiology0.86074679
105MP0005410_abnormal_fertilization0.85674474
106MP0005025_abnormal_response_to0.85179457
107MP0001879_abnormal_lymphatic_vessel0.85034881
108MP0005387_immune_system_phenotype0.84440162
109MP0001790_abnormal_immune_system0.84440162
110MP0003718_maternal_effect0.84317455
111MP0002925_abnormal_cardiovascular_devel0.83370033
112MP0004036_abnormal_muscle_relaxation0.82939895
113MP0000767_abnormal_smooth_muscle0.82205706
114MP0003866_abnormal_defecation0.82130921
115MP0000371_diluted_coat_color0.82074368
116MP0002085_abnormal_embryonic_tissue0.81707315
117MP0001145_abnormal_male_reproductive0.80620658
118MP0000685_abnormal_immune_system0.80190474
119MP0000383_abnormal_hair_follicle0.78623427
120MP0004084_abnormal_cardiac_muscle0.78503158
121MP0004134_abnormal_chest_morphology0.77506394
122MP0004381_abnormal_hair_follicle0.77004802
123MP0010678_abnormal_skin_adnexa0.76614821
124MP0001845_abnormal_inflammatory_respons0.72965634
125MP0005220_abnormal_exocrine_pancreas0.69980026
126MP0001851_eye_inflammation0.68678535
127MP0005389_reproductive_system_phenotype0.67409848
128MP0009765_abnormal_xenobiotic_induced0.67405079
129MP0004947_skin_inflammation0.66757907
130MP0008995_early_reproductive_senescence0.66188060
131MP0003806_abnormal_nucleotide_metabolis0.64979229
132MP0006036_abnormal_mitochondrial_physio0.61603176
133MP0004484_altered_response_of0.61284078

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)3.72280748
2Severe combined immunodeficiency (HP:0004430)3.60684242
3Autoimmune hemolytic anemia (HP:0001890)3.58740960
4IgM deficiency (HP:0002850)3.50976168
5B lymphocytopenia (HP:0010976)3.50302087
6Syringomyelia (HP:0003396)3.47012776
7Spinal cord lesions (HP:0100561)3.47012776
8Combined immunodeficiency (HP:0005387)3.42553513
9Absent frontal sinuses (HP:0002688)3.26450508
10Abnormality of T cells (HP:0002843)3.16764955
11Chromsome breakage (HP:0040012)3.04289538
12IgG deficiency (HP:0004315)3.01027519
1311 pairs of ribs (HP:0000878)2.94952720
14Panhypogammaglobulinemia (HP:0003139)2.91891973
15Rhabdomyosarcoma (HP:0002859)2.78196359
16Acute lymphatic leukemia (HP:0006721)2.77953705
17Volvulus (HP:0002580)2.76646709
18Ectopic kidney (HP:0000086)2.65755568
19Granulocytopenia (HP:0001913)2.62723443
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62261337
21Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.61381299
22Abnormality of T cell physiology (HP:0011840)2.55214253
23Eosinophilia (HP:0001880)2.51635494
24Acute myeloid leukemia (HP:0004808)2.50775170
25Abnormality of eosinophils (HP:0001879)2.49229322
26Abnormality of chromosome stability (HP:0003220)2.48886896
27Abnormality of the anterior horn cell (HP:0006802)2.44169857
28Degeneration of anterior horn cells (HP:0002398)2.44169857
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.42466462
30Deep philtrum (HP:0002002)2.37528616
31Agnosia (HP:0010524)2.35127597
32Aplastic anemia (HP:0001915)2.28529603
33Neoplasm of the adrenal cortex (HP:0100641)2.28273663
34Chronic diarrhea (HP:0002028)2.27587415
35Spontaneous hematomas (HP:0007420)2.23632216
36Short 4th metacarpal (HP:0010044)2.22472371
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22472371
38Fatigue (HP:0012378)2.22100949
39Subacute progressive viral hepatitis (HP:0006572)2.22090713
40Cutaneous melanoma (HP:0012056)2.21413792
41Stomatitis (HP:0010280)2.20593611
42Asymmetry of the thorax (HP:0001555)2.19197778
43Colon cancer (HP:0003003)2.18364848
44Lymphopenia (HP:0001888)2.17869668
45Basal cell carcinoma (HP:0002671)2.17576962
46Pancreatic islet-cell hyperplasia (HP:0004510)2.16755632
47Myelodysplasia (HP:0002863)2.15979165
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.14714289
49Osteolytic defects of the hand bones (HP:0009699)2.14714289
50Dyschromatopsia (HP:0007641)2.14312984
51Abnormality of DNA repair (HP:0003254)2.13902263
52Dislocated radial head (HP:0003083)2.11710877
53Cafe-au-lait spot (HP:0000957)2.11257389
54Leukocytosis (HP:0001974)2.11010572
55Long clavicles (HP:0000890)2.10256967
56Prostate neoplasm (HP:0100787)2.08917166
57Prolonged bleeding time (HP:0003010)2.08383160
58Abnormality of the frontal sinuses (HP:0002687)2.08356436
59Stomach cancer (HP:0012126)2.07880830
60Abnormality of the fingertips (HP:0001211)2.07870861
61Neoplasm of the tracheobronchial system (HP:0100552)2.06295381
62Optic neuritis (HP:0100653)2.04145217
63Retrobulbar optic neuritis (HP:0100654)2.04145217
64Biliary tract neoplasm (HP:0100574)2.03756563
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.03682279
66T lymphocytopenia (HP:0005403)2.02092892
67Mesomelia (HP:0003027)2.01547173
68Nephroblastoma (Wilms tumor) (HP:0002667)2.01303656
69Meningioma (HP:0002858)2.00802028
70Meckel diverticulum (HP:0002245)2.00459312
71Neoplasm of the small intestine (HP:0100833)1.99566753
72Sandal gap (HP:0001852)1.99127063
73Papillary thyroid carcinoma (HP:0002895)1.98732120
74Agammaglobulinemia (HP:0004432)1.98282926
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.98063758
76Abnormality of the duodenum (HP:0002246)1.97867886
77Abnormality of T cell number (HP:0011839)1.94828668
78Abnormality of the radial head (HP:0003995)1.93648000
79Selective tooth agenesis (HP:0001592)1.93535191
80Pancytopenia (HP:0001876)1.92884759
81Carpal bone hypoplasia (HP:0001498)1.92425151
82Abnormal spermatogenesis (HP:0008669)1.91787536
83Birth length less than 3rd percentile (HP:0003561)1.91733000
84Chronic mucocutaneous candidiasis (HP:0002728)1.91565535
85Recurrent cutaneous fungal infections (HP:0011370)1.91565535
86Hypoplasia of the thymus (HP:0000778)1.91530540
87Viral hepatitis (HP:0006562)1.91113964
88Central scotoma (HP:0000603)1.90563477
89Myositis (HP:0100614)1.90330425
90Pelvic girdle muscle weakness (HP:0003749)1.89952094
91Medulloblastoma (HP:0002885)1.89855857
92Meningitis (HP:0001287)1.89701917
93Microvesicular hepatic steatosis (HP:0001414)1.89240615
94Neoplasm of the colon (HP:0100273)1.87136760
95Embryonal renal neoplasm (HP:0011794)1.86513970
96Abnormality of the ileum (HP:0001549)1.85983832
97Pustule (HP:0200039)1.85490476
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.84694290
99Deviation of the thumb (HP:0009603)1.84433169
100Amaurosis fugax (HP:0100576)1.83599339
101Abnormality of the calcaneus (HP:0008364)1.83389105
102Chest pain (HP:0100749)1.83198738
103Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82965282
104Recurrent viral infections (HP:0004429)1.82366375
105Abnormality of the pancreatic islet cells (HP:0006476)1.82243880
106Abnormality of endocrine pancreas physiology (HP:0012093)1.82243880
107Broad palm (HP:0001169)1.81650517
108Missing ribs (HP:0000921)1.81648771
109Renal cortical cysts (HP:0000803)1.81053939
110Stillbirth (HP:0003826)1.80926515
111Orchitis (HP:0100796)1.80737092
112Abnormality of the thymus (HP:0000777)1.79168178
113Abnormality of the hip-girdle musculature (HP:0001445)1.77306241
114Abnormality of the musculature of the pelvis (HP:0001469)1.77306241
115Hematochezia (HP:0002573)1.77003774
116Encephalitis (HP:0002383)1.75500808
117Lymphoma (HP:0002665)1.75236612
118Short nail (HP:0001799)1.74214894
119Abnormality of the nasal septum (HP:0000419)1.73965297
120Cutis marmorata (HP:0000965)1.73361732
121Alveolar cell carcinoma (HP:0006519)1.72681214
122Epistaxis (HP:0000421)1.71870748
123Recurrent abscess formation (HP:0002722)1.71432761
124Skull defect (HP:0001362)1.71399643
125Increased density of long bones (HP:0006392)1.70740393
126Irregular epiphyses (HP:0010582)1.70116516
127Recurrent bronchitis (HP:0002837)1.68958594
128Mild short stature (HP:0003502)1.68855198
129High pitched voice (HP:0001620)1.67738763
130Mediastinal lymphadenopathy (HP:0100721)1.66051643
131Fibular hypoplasia (HP:0003038)1.65329643
132Clubbing of toes (HP:0100760)1.65111958
133Small intestinal stenosis (HP:0012848)1.64062702
134Duodenal stenosis (HP:0100867)1.64062702
135Glomerulopathy (HP:0100820)1.62939982
136Abnormal platelet volume (HP:0011876)1.62455935
137Long eyelashes (HP:0000527)1.61052573
138Abnormality of the prostate (HP:0008775)1.58518588
139Thyroid carcinoma (HP:0002890)1.58495475
140Hypoplastic ischia (HP:0003175)1.58310157
141IgA deficiency (HP:0002720)1.58050204
142Impulsivity (HP:0100710)1.57706949
143Prominent nose (HP:0000448)1.56699121
144Proximal placement of thumb (HP:0009623)1.55037089
145Cystic hygroma (HP:0000476)1.54423767
146Thrombocytosis (HP:0001894)1.54298571
147Arterial thrombosis (HP:0004420)1.54171457
148Aortic aneurysm (HP:0004942)1.53960843
149Abnormal lung lobation (HP:0002101)1.53882825
150Keratoconjunctivitis sicca (HP:0001097)1.53621920
151Increased mean platelet volume (HP:0011877)1.53327449
152Abnormality of the preputium (HP:0100587)1.53276741
153Thyroiditis (HP:0100646)1.52022332
154Metaphyseal cupping (HP:0003021)1.51720648
155Azoospermia (HP:0000027)1.50429691
156Epiphyseal dysplasia (HP:0002656)1.50296508
157Sloping forehead (HP:0000340)1.49810322
158Recurrent fungal infections (HP:0002841)1.49020098
159Eczematoid dermatitis (HP:0000976)1.48905069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.02757158
2CDC72.97934587
3CDK122.90730808
4ZAK2.45711470
5TXK2.40302379
6FRK2.38872015
7MAP3K142.25703466
8ERBB32.12646073
9STK102.07046792
10ACVR1B2.04468761
11STK32.03556899
12TSSK61.99005282
13PLK41.98318128
14EIF2AK11.98308444
15TGFBR11.97963643
16BRD41.95168867
17NEK91.82493917
18MKNK11.82059292
19JAK31.78186111
20PLK31.74080322
21MKNK21.70476968
22ATR1.63181039
23NUAK11.58707691
24BTK1.56744117
25PASK1.54923890
26MAP4K11.53313934
27BUB11.50627805
28SRPK11.46302599
29PIK3CG1.43725038
30TAF11.43139886
31RPS6KA41.40857942
32TRPM71.40689473
33NEK21.39258149
34BMPR1B1.32156441
35STK241.31738896
36WEE11.29520391
37IRAK31.29382725
38PIM11.27743003
39TEC1.27508022
40STK41.26020139
41TTK1.23649105
42ATM1.21688941
43SYK1.21322398
44CDK61.21067295
45PLK21.20943650
46BRSK21.20692700
47FGFR31.16969198
48PDK21.16822210
49CHUK1.16031440
50EPHA21.15648553
51FLT31.13643552
52PLK11.11446154
53LATS11.11282851
54MAP2K31.06612259
55AURKB1.05476117
56PDK41.05407108
57PDK31.05407108
58FES1.01622879
59IRAK41.01099467
60TYK20.99527185
61CHEK10.99120889
62ITK0.98358311
63MELK0.93538674
64MARK30.91232045
65TTN0.91211184
66RPS6KB20.88965902
67IKBKB0.88830524
68CDK70.87972690
69CLK10.85568262
70RIPK40.84791359
71EPHA30.84070637
72CHEK20.83953310
73TESK10.83676799
74OBSCN0.83634358
75MAP3K30.82584676
76TNIK0.81801647
77CDK90.80112168
78CDK40.79610678
79MAP3K130.76070295
80CCNB10.75385137
81TGFBR20.75163417
82LYN0.72849944
83HCK0.72665994
84SCYL20.72302342
85PKN20.71814720
86JAK10.71808807
87STK38L0.69657646
88MAP3K80.69190778
89EIF2AK20.68618604
90IKBKE0.67297134
91NEK10.66814608
92ZAP700.66658007
93CDK80.66337739
94EEF2K0.65754330
95MST40.64556859
96TLK10.63007985
97PRKCQ0.62460028
98LCK0.60992800
99CSF1R0.60888542
100RPS6KB10.59389816
101VRK10.57818046
102TBK10.57807923
103BMPR20.56901180
104CDK20.56866931
105NLK0.56149296
106YES10.55957489
107ALK0.51576488
108MAPK110.50594397
109CAMKK20.50337036
110PDGFRB0.50319700
111MAP3K100.50067871
112EIF2AK30.48165616
113KIT0.47433305
114PRPF4B0.47134109
115CDK10.45893579
116CAMK1G0.45473950
117RPS6KA50.45319445
118PBK0.45031226
119PDGFRA0.44349253
120CSK0.43937639
121NEK60.43202201
122PRKDC0.41676721
123AKT30.41458212
124FGFR20.41185810
125MAP2K60.40546195
126WNK30.35418496
127WNK10.34345236

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.52497859
2DNA replication_Homo sapiens_hsa030302.49372401
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48715875
4Cell cycle_Homo sapiens_hsa041102.28997896
5Non-homologous end-joining_Homo sapiens_hsa034502.24120849
6RNA transport_Homo sapiens_hsa030132.16120582
7Fanconi anemia pathway_Homo sapiens_hsa034602.08471032
8Homologous recombination_Homo sapiens_hsa034402.01204776
9Antigen processing and presentation_Homo sapiens_hsa046121.85367179
10One carbon pool by folate_Homo sapiens_hsa006701.84841812
11Base excision repair_Homo sapiens_hsa034101.83113768
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.76382259
13Spliceosome_Homo sapiens_hsa030401.73207875
14Measles_Homo sapiens_hsa051621.70168957
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65096558
16Legionellosis_Homo sapiens_hsa051341.60490970
17Herpes simplex infection_Homo sapiens_hsa051681.59226967
18mRNA surveillance pathway_Homo sapiens_hsa030151.58943519
19RNA degradation_Homo sapiens_hsa030181.58174194
20Basal transcription factors_Homo sapiens_hsa030221.56085883
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54070601
22Nucleotide excision repair_Homo sapiens_hsa034201.48579033
23Viral carcinogenesis_Homo sapiens_hsa052031.46533937
24p53 signaling pathway_Homo sapiens_hsa041151.45446514
25Leishmaniasis_Homo sapiens_hsa051401.43419277
26Viral myocarditis_Homo sapiens_hsa054161.40408993
27Systemic lupus erythematosus_Homo sapiens_hsa053221.33070729
28Epstein-Barr virus infection_Homo sapiens_hsa051691.30966103
29Primary immunodeficiency_Homo sapiens_hsa053401.30774528
30Allograft rejection_Homo sapiens_hsa053301.27694558
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25808413
32MicroRNAs in cancer_Homo sapiens_hsa052061.23765084
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22338314
34Adherens junction_Homo sapiens_hsa045201.20230868
35HTLV-I infection_Homo sapiens_hsa051661.18889501
36Graft-versus-host disease_Homo sapiens_hsa053321.18536918
37Hepatitis B_Homo sapiens_hsa051611.18435482
38Influenza A_Homo sapiens_hsa051641.17932437
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17383721
40Small cell lung cancer_Homo sapiens_hsa052221.13713962
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11877824
42Osteoclast differentiation_Homo sapiens_hsa043801.11537715
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09658154
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08956996
45Hematopoietic cell lineage_Homo sapiens_hsa046401.08309798
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.08239804
47Toxoplasmosis_Homo sapiens_hsa051451.06627811
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05847713
49T cell receptor signaling pathway_Homo sapiens_hsa046601.05676705
50B cell receptor signaling pathway_Homo sapiens_hsa046621.05021018
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04257621
52Non-small cell lung cancer_Homo sapiens_hsa052231.03857722
53TNF signaling pathway_Homo sapiens_hsa046681.02199216
54Apoptosis_Homo sapiens_hsa042101.00803413
55Selenocompound metabolism_Homo sapiens_hsa004501.00054627
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98193243
57TGF-beta signaling pathway_Homo sapiens_hsa043500.97141203
58RNA polymerase_Homo sapiens_hsa030200.96572304
59Chronic myeloid leukemia_Homo sapiens_hsa052200.95965443
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95569016
61Prostate cancer_Homo sapiens_hsa052150.93707837
62Shigellosis_Homo sapiens_hsa051310.91919717
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.90438900
64Pyrimidine metabolism_Homo sapiens_hsa002400.89045693
65Type I diabetes mellitus_Homo sapiens_hsa049400.87621423
66Proteasome_Homo sapiens_hsa030500.87185133
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87042263
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84230997
69Pancreatic cancer_Homo sapiens_hsa052120.82491678
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81199274
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.80308914
72Malaria_Homo sapiens_hsa051440.79742017
73Lysine degradation_Homo sapiens_hsa003100.79121062
74Salmonella infection_Homo sapiens_hsa051320.78155764
75Focal adhesion_Homo sapiens_hsa045100.74613238
76Colorectal cancer_Homo sapiens_hsa052100.74110572
77ECM-receptor interaction_Homo sapiens_hsa045120.73923261
78Proteoglycans in cancer_Homo sapiens_hsa052050.70706611
79Thyroid cancer_Homo sapiens_hsa052160.70187448
80Acute myeloid leukemia_Homo sapiens_hsa052210.69923713
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69788072
82Protein export_Homo sapiens_hsa030600.69510214
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69483676
84Tuberculosis_Homo sapiens_hsa051520.67590813
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65433237
86Asthma_Homo sapiens_hsa053100.65402736
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64338482
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62905332
89FoxO signaling pathway_Homo sapiens_hsa040680.60364879
90Inositol phosphate metabolism_Homo sapiens_hsa005620.60183248
91Pertussis_Homo sapiens_hsa051330.58799184
92Alcoholism_Homo sapiens_hsa050340.57475234
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57469750
94N-Glycan biosynthesis_Homo sapiens_hsa005100.54003603
95HIF-1 signaling pathway_Homo sapiens_hsa040660.53978252
96mTOR signaling pathway_Homo sapiens_hsa041500.52970977
97Pathways in cancer_Homo sapiens_hsa052000.52919105
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52660257
99Phagosome_Homo sapiens_hsa041450.52505748
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51340697
101Propanoate metabolism_Homo sapiens_hsa006400.50644622
102Hepatitis C_Homo sapiens_hsa051600.50503091
103Purine metabolism_Homo sapiens_hsa002300.48599367
104Hippo signaling pathway_Homo sapiens_hsa043900.48317351
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48012239
106Oocyte meiosis_Homo sapiens_hsa041140.47822710
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46759032
108Platelet activation_Homo sapiens_hsa046110.46429059
109Endometrial cancer_Homo sapiens_hsa052130.45703935
110Chemokine signaling pathway_Homo sapiens_hsa040620.44304675
111Melanoma_Homo sapiens_hsa052180.43696463
112Regulation of autophagy_Homo sapiens_hsa041400.39854671
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.33603086
114Staphylococcus aureus infection_Homo sapiens_hsa051500.32647965
115Prolactin signaling pathway_Homo sapiens_hsa049170.28523364
116Dorso-ventral axis formation_Homo sapiens_hsa043200.28494206
117Renal cell carcinoma_Homo sapiens_hsa052110.26524357
118Insulin resistance_Homo sapiens_hsa049310.26345946
119Glioma_Homo sapiens_hsa052140.24577971
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24302454
121Rheumatoid arthritis_Homo sapiens_hsa053230.22770042
122Circadian rhythm_Homo sapiens_hsa047100.21789550

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