TPPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.25393615
2axon ensheathment in central nervous system (GO:0032291)6.25393615
3sodium ion export (GO:0071436)5.83004479
4synaptic vesicle maturation (GO:0016188)4.93008324
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82544736
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77496333
7positive regulation of synapse maturation (GO:0090129)4.73275557
8neuronal action potential propagation (GO:0019227)4.65868805
9locomotory exploration behavior (GO:0035641)4.61838247
10synaptic vesicle exocytosis (GO:0016079)4.50914939
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.45236628
12potassium ion homeostasis (GO:0055075)4.44985298
13glutamate secretion (GO:0014047)4.42504415
14L-amino acid import (GO:0043092)4.39358793
15neuron cell-cell adhesion (GO:0007158)4.31364679
16regulation of synaptic vesicle exocytosis (GO:2000300)4.31121140
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.29107527
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23317075
19potassium ion import (GO:0010107)4.22972355
20vocalization behavior (GO:0071625)4.17787969
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16987686
22myelination (GO:0042552)4.05594351
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.03747964
24axon ensheathment (GO:0008366)4.02172523
25ensheathment of neurons (GO:0007272)4.02172523
26postsynaptic membrane organization (GO:0001941)3.95446585
27presynaptic membrane assembly (GO:0097105)3.95265375
28regulation of ARF protein signal transduction (GO:0032012)3.94202875
29presynaptic membrane organization (GO:0097090)3.94186848
30transmission of nerve impulse (GO:0019226)3.91957216
31cell communication by electrical coupling (GO:0010644)3.80907856
32regulation of neuronal synaptic plasticity (GO:0048168)3.79677422
33regulation of glutamate receptor signaling pathway (GO:1900449)3.78664080
34protein localization to synapse (GO:0035418)3.76734677
35negative regulation of neurotransmitter transport (GO:0051589)3.75246515
36cellular sodium ion homeostasis (GO:0006883)3.74930629
37cerebellar Purkinje cell differentiation (GO:0021702)3.74515869
38negative regulation of dendrite morphogenesis (GO:0050774)3.74107328
39regulation of synapse maturation (GO:0090128)3.71279444
40regulation of synaptic vesicle transport (GO:1902803)3.70736523
41long-chain fatty acid biosynthetic process (GO:0042759)3.70224129
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68212357
43dendritic spine morphogenesis (GO:0060997)3.68163152
44negative regulation of neurotransmitter secretion (GO:0046929)3.62190669
45synaptic transmission, glutamatergic (GO:0035249)3.61879837
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61578977
47positive regulation of neurotransmitter secretion (GO:0001956)3.60914219
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.59833868
49fatty acid elongation (GO:0030497)3.58505945
50positive regulation of neurotransmitter transport (GO:0051590)3.58478467
51neuron-neuron synaptic transmission (GO:0007270)3.58183126
52glutamate receptor signaling pathway (GO:0007215)3.57375006
53exploration behavior (GO:0035640)3.52249716
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.49996329
55gamma-aminobutyric acid transport (GO:0015812)3.49728546
56adult walking behavior (GO:0007628)3.48142373
57neuronal ion channel clustering (GO:0045161)3.46642580
58positive regulation of membrane potential (GO:0045838)3.41957609
59neurotransmitter secretion (GO:0007269)3.41566564
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.39767664
61long-term memory (GO:0007616)3.35697880
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34521845
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34300852
64proline transport (GO:0015824)3.31162367
65neuron recognition (GO:0008038)3.29786462
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.29463602
67regulation of dendritic spine morphogenesis (GO:0061001)3.28101960
68amino acid import (GO:0043090)3.27651956
69neurotransmitter-gated ion channel clustering (GO:0072578)3.26722100
70membrane depolarization during action potential (GO:0086010)3.25630989
71regulation of synaptic transmission (GO:0050804)3.21960550
72regulation of synapse structural plasticity (GO:0051823)3.18409497
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18231622
74regulation of postsynaptic membrane potential (GO:0060078)3.15240510
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13960381
76regulation of synaptic plasticity (GO:0048167)3.13695090
77long-term synaptic potentiation (GO:0060291)3.13311156
78glycine transport (GO:0015816)3.12901267
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12885317
80cerebellar granule cell differentiation (GO:0021707)3.12468903
81vesicle docking involved in exocytosis (GO:0006904)3.10813937
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08586146
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08356862
84neurotransmitter transport (GO:0006836)3.07151600
85regulation of voltage-gated calcium channel activity (GO:1901385)3.06794324
86establishment of synaptic vesicle localization (GO:0097480)3.06337262
87synaptic vesicle transport (GO:0048489)3.06337262
88cellular potassium ion homeostasis (GO:0030007)3.05793497
89layer formation in cerebral cortex (GO:0021819)3.05534596
90neuromuscular process controlling posture (GO:0050884)3.05265563
91synaptic transmission (GO:0007268)3.05198887
92cell differentiation in hindbrain (GO:0021533)3.05167687
93detection of calcium ion (GO:0005513)3.03072159
94cell communication involved in cardiac conduction (GO:0086065)3.02651740
95activation of protein kinase A activity (GO:0034199)3.02651076
96neuromuscular synaptic transmission (GO:0007274)3.02260770
97membrane hyperpolarization (GO:0060081)2.99805187
98neuromuscular process (GO:0050905)2.98310256
99regulation of neurotransmitter secretion (GO:0046928)2.97634396
100axonal fasciculation (GO:0007413)2.97630031
101regulation of dendritic spine development (GO:0060998)2.96778544
102neuromuscular process controlling balance (GO:0050885)2.95058417
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94419361
104chemosensory behavior (GO:0007635)2.93094389
105nerve growth factor signaling pathway (GO:0038180)2.92852333
106regulation of exocytosis (GO:0017157)2.92707840
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.90033828
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.89874486
109dendrite morphogenesis (GO:0048813)2.86979244
110mating behavior (GO:0007617)2.86548408
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86316637
112negative regulation of protein localization to cell surface (GO:2000009)2.82513922
113apical protein localization (GO:0045176)2.81859382
114regulation of neurotransmitter levels (GO:0001505)2.81380569
115establishment of mitochondrion localization (GO:0051654)2.81263028
116auditory behavior (GO:0031223)2.81235448
117regulation of neurotransmitter transport (GO:0051588)2.80709970
118negative regulation of axonogenesis (GO:0050771)2.80412254
119glycerophospholipid catabolic process (GO:0046475)2.78301670
120dendritic spine organization (GO:0097061)2.74753794
121neurotransmitter uptake (GO:0001504)2.73785766
122behavioral response to cocaine (GO:0048148)2.73709181
123regulation of glutamate secretion (GO:0014048)2.73591041
124membrane depolarization (GO:0051899)2.72183398
125synaptic vesicle endocytosis (GO:0048488)2.71790243
126learning (GO:0007612)2.71448078
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70641560
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69119248
129oligodendrocyte differentiation (GO:0048709)2.68682672
130acidic amino acid transport (GO:0015800)2.66634747
131regulation of vesicle fusion (GO:0031338)2.66328365
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66210114
133positive regulation of dendritic spine development (GO:0060999)2.66199005
134L-glutamate transport (GO:0015813)2.65283165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.85691443
2GBX2_23144817_ChIP-Seq_PC3_Human3.71276958
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00136509
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96041102
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87232909
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64198407
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57440061
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57440061
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46844097
10DROSHA_22980978_ChIP-Seq_HELA_Human2.45144285
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44706888
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41458080
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.39697298
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37837680
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36835003
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.35603550
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34587688
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.27264201
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18357923
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.16970509
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12610482
22TAF15_26573619_Chip-Seq_HEK293_Human2.06144278
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05000393
24AR_21572438_ChIP-Seq_LNCaP_Human1.96913378
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.91665127
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.89815427
27* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82594594
28KDM2B_26808549_Chip-Seq_K562_Human1.78559627
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76024598
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69902414
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64611368
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63333653
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60297950
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58343537
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56842862
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53858736
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49536613
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49453150
39SMAD4_21799915_ChIP-Seq_A2780_Human1.47719622
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.47257456
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45345226
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44457034
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41873310
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.41260051
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38780623
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37800957
47P300_19829295_ChIP-Seq_ESCs_Human1.37685246
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34975836
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34941215
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34783784
51* TET1_21490601_ChIP-Seq_MESCs_Mouse1.32620811
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32103668
53CTCF_27219007_Chip-Seq_Bcells_Human1.31453354
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31325892
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.31251887
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31223427
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31006865
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28329391
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.27934280
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.26442354
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25013691
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24542248
63STAT3_23295773_ChIP-Seq_U87_Human1.24289215
64LXR_22292898_ChIP-Seq_THP-1_Human1.23505155
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22803825
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22547013
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22090834
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21398743
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.20687224
70ER_23166858_ChIP-Seq_MCF-7_Human1.20642355
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18969094
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18850558
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16866883
74VDR_22108803_ChIP-Seq_LS180_Human1.16483110
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16379518
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13619083
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12661518
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11622817
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11146771
80TCF4_23295773_ChIP-Seq_U87_Human1.11102687
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10461220
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09655981
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07015983
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06142287
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05755607
86AR_25329375_ChIP-Seq_VCAP_Human1.05567242
87FUS_26573619_Chip-Seq_HEK293_Human1.05515450
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.05346212
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.04508879
90* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04400930
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04078247
92AHR_22903824_ChIP-Seq_MCF-7_Human1.02966857
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.02764844
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01690784
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01441019
96* OCT4_19829295_ChIP-Seq_ESCs_Human1.00929172
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00701891
98AR_19668381_ChIP-Seq_PC3_Human1.00484353
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.00115794
100TP53_16413492_ChIP-PET_HCT116_Human0.99858993
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.99796727
102* SMC4_20622854_ChIP-Seq_HELA_Human0.99095999
103ZNF274_21170338_ChIP-Seq_K562_Hela0.99060708
104RNF2_27304074_Chip-Seq_NSC_Mouse0.98172908
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97194499
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96452363
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95716929
108* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95067102
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94024081
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92626016
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.92401972
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.92008570
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91667952
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.91109933
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90851314
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90399894
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90162805
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88709394
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88022586
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.87863785
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87592432
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87478369
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87478369
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.86996387
125KLF4_19829295_ChIP-Seq_ESCs_Human0.86803681
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.86318679
127CREB1_26743006_Chip-Seq_LNCaP_Human0.86104572
128RXR_22108803_ChIP-Seq_LS180_Human0.85558669
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.85266946
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85111132
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83855180
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81778823
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81753632
134KDM2B_26808549_Chip-Seq_DND41_Human0.81206776
135SMAD4_21741376_ChIP-Seq_ESCs_Human0.79307559
136* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79205898
137MYC_19915707_ChIP-ChIP_AK7_Human0.78027419
138EGR1_19032775_ChIP-ChIP_M12_Human0.76552357
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.75565358
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75381923
141RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75072608
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.73219802
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.72729245
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72452789
145* P68_20966046_ChIP-Seq_HELA_Human0.71679398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78504646
2MP0003880_abnormal_central_pattern5.39626421
3MP0004270_analgesia3.95532464
4MP0003635_abnormal_synaptic_transmissio3.74514393
5MP0002064_seizures3.30880370
6MP0009745_abnormal_behavioral_response3.28060335
7MP0009046_muscle_twitch3.01769039
8MP0002272_abnormal_nervous_system2.99257502
9MP0000920_abnormal_myelination2.97868398
10MP0002063_abnormal_learning/memory/cond2.92210358
11MP0001486_abnormal_startle_reflex2.90029016
12MP0002822_catalepsy2.63573551
13MP0005423_abnormal_somatic_nervous2.57783125
14MP0002572_abnormal_emotion/affect_behav2.56913217
15MP0002734_abnormal_mechanical_nocicepti2.43295345
16MP0003329_amyloid_beta_deposits2.42509377
17MP0001968_abnormal_touch/_nociception2.41290957
18MP0003690_abnormal_glial_cell2.23228705
19MP0004885_abnormal_endolymph2.14066202
20MP0001529_abnormal_vocalization2.04901271
21MP0001440_abnormal_grooming_behavior2.03772405
22MP0001501_abnormal_sleep_pattern2.01108610
23MP0000778_abnormal_nervous_system1.94621899
24MP0008569_lethality_at_weaning1.90804635
25MP0001905_abnormal_dopamine_level1.90696224
26MP0002067_abnormal_sensory_capabilities1.84142225
27MP0002736_abnormal_nociception_after1.80065542
28MP0001970_abnormal_pain_threshold1.76073069
29MP0004142_abnormal_muscle_tone1.75975705
30MP0004924_abnormal_behavior1.70568120
31MP0005386_behavior/neurological_phenoty1.70568120
32MP0004742_abnormal_vestibular_system1.66082970
33MP0002733_abnormal_thermal_nociception1.65378323
34MP0002735_abnormal_chemical_nociception1.60055300
35MP0000955_abnormal_spinal_cord1.56917948
36MP0009780_abnormal_chondrocyte_physiolo1.56243157
37MP0003633_abnormal_nervous_system1.53465614
38MP0003634_abnormal_glial_cell1.51132908
39MP0002066_abnormal_motor_capabilities/c1.50296891
40MP0002882_abnormal_neuron_morphology1.49150822
41MP0002229_neurodegeneration1.44706634
42MP0001485_abnormal_pinna_reflex1.44550727
43MP0003631_nervous_system_phenotype1.43339773
44MP0004811_abnormal_neuron_physiology1.42798420
45MP0002557_abnormal_social/conspecific_i1.40081457
46MP0005646_abnormal_pituitary_gland1.39572632
47MP0003123_paternal_imprinting1.36438411
48MP0002184_abnormal_innervation1.33598195
49MP0003632_abnormal_nervous_system1.33319520
50MP0005171_absent_coat_pigmentation1.28663550
51MP0005409_darkened_coat_color1.27734372
52MP0005551_abnormal_eye_electrophysiolog1.17899536
53MP0000604_amyloidosis1.17428278
54MP0004043_abnormal_pH_regulation1.13011068
55MP0003879_abnormal_hair_cell1.12909650
56MP0001502_abnormal_circadian_rhythm1.11818928
57MP0001177_atelectasis1.09521663
58MP0001984_abnormal_olfaction1.08447872
59MP0005645_abnormal_hypothalamus_physiol1.05754320
60MP0001963_abnormal_hearing_physiology1.04728816
61MP0002152_abnormal_brain_morphology1.03110251
62MP0006276_abnormal_autonomic_nervous1.02575351
63MP0004858_abnormal_nervous_system1.01658596
64MP0004145_abnormal_muscle_electrophysio0.98880450
65MP0003950_abnormal_plasma_membrane0.95311842
66MP0002909_abnormal_adrenal_gland0.94715332
67MP0003787_abnormal_imprinting0.93846477
68MP0008874_decreased_physiological_sensi0.93105402
69MP0005410_abnormal_fertilization0.92806140
70MP0003075_altered_response_to0.90963286
71MP0005623_abnormal_meninges_morphology0.90814792
72MP0002752_abnormal_somatic_nervous0.87964061
73MP0008872_abnormal_physiological_respon0.84034837
74MP0002090_abnormal_vision0.82541594
75MP0002638_abnormal_pupillary_reflex0.80600391
76MP0001348_abnormal_lacrimal_gland0.80554421
77MP0000751_myopathy0.80265299
78MP0002069_abnormal_eating/drinking_beha0.80021311
79MP0000747_muscle_weakness0.75601819
80MP0001986_abnormal_taste_sensitivity0.75506585
81MP0004085_abnormal_heartbeat0.73484288
82MP0000013_abnormal_adipose_tissue0.73348207
83MP0001299_abnormal_eye_distance/0.69743637
84MP0005535_abnormal_body_temperature0.68610350
85MP0003122_maternal_imprinting0.66744070
86MP0004130_abnormal_muscle_cell0.66193840
87MP0003136_yellow_coat_color0.65671128
88MP0003137_abnormal_impulse_conducting0.65567973
89MP0000579_abnormal_nail_morphology0.64824731
90MP0003172_abnormal_lysosome_physiology0.64229730
91MP0010678_abnormal_skin_adnexa0.62967963
92MP0000566_synostosis0.62767330
93MP0001188_hyperpigmentation0.62171424
94MP0001664_abnormal_digestion0.61644809
95MP0000631_abnormal_neuroendocrine_gland0.59296729
96MP0010386_abnormal_urinary_bladder0.58394556
97MP0005167_abnormal_blood-brain_barrier0.57279320
98MP0001943_abnormal_respiration0.56642796
99MP0000026_abnormal_inner_ear0.55625408
100MP0005166_decreased_susceptibility_to0.54579158
101MP0000462_abnormal_digestive_system0.53339229
102MP0001346_abnormal_lacrimal_gland0.52656571
103MP0010768_mortality/aging0.52298919
104MP0004036_abnormal_muscle_relaxation0.51565059
105MP0003045_fibrosis0.51389042
106MP0003283_abnormal_digestive_organ0.51220195
107MP0003956_abnormal_body_size0.50206244
108MP0004147_increased_porphyrin_level0.49949256
109MP0004510_myositis0.48496423
110MP0010769_abnormal_survival0.48157387
111MP0003938_abnormal_ear_development0.47491300
112MP0005195_abnormal_posterior_eye0.47101157
113MP0002837_dystrophic_cardiac_calcinosis0.47025685
114MP0002082_postnatal_lethality0.45552043
115MP0010770_preweaning_lethality0.45552043
116MP0008877_abnormal_DNA_methylation0.45473289
117MP0005388_respiratory_system_phenotype0.45057521
118MP0002133_abnormal_respiratory_system0.45057521
119MP0001765_abnormal_ion_homeostasis0.43886684

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.68532621
2Myokymia (HP:0002411)6.26150800
3Neurofibrillary tangles (HP:0002185)4.90392077
4Focal seizures (HP:0007359)4.79528023
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.64812984
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.64812984
7Atonic seizures (HP:0010819)4.24706784
8Supranuclear gaze palsy (HP:0000605)4.11499564
9Epileptic encephalopathy (HP:0200134)4.07227705
10Abnormality of the corticospinal tract (HP:0002492)3.97397996
11Cerebral inclusion bodies (HP:0100314)3.92953046
12Dysmetria (HP:0001310)3.88594378
13Obstructive sleep apnea (HP:0002870)3.75282325
14Visual hallucinations (HP:0002367)3.71138168
15Ankle clonus (HP:0011448)3.70846854
16Spastic gait (HP:0002064)3.66954884
17Intention tremor (HP:0002080)3.63595148
18Annular pancreas (HP:0001734)3.62683380
19Action tremor (HP:0002345)3.57043339
20Peripheral hypomyelination (HP:0007182)3.50602383
21Sensory axonal neuropathy (HP:0003390)3.44661883
22Scanning speech (HP:0002168)3.43287591
23Tetraplegia (HP:0002445)3.38468188
24Dialeptic seizures (HP:0011146)3.38082087
25Absence seizures (HP:0002121)3.33774359
26Hemiplegia (HP:0002301)3.30732427
27Progressive cerebellar ataxia (HP:0002073)3.25463296
28Insidious onset (HP:0003587)3.22961823
29Termporal pattern (HP:0011008)3.22961823
30Broad-based gait (HP:0002136)3.21897571
31Generalized tonic-clonic seizures (HP:0002069)3.15434279
32Dysdiadochokinesis (HP:0002075)3.09381245
33Hyperventilation (HP:0002883)3.07290710
34Gaze-evoked nystagmus (HP:0000640)3.06128561
35Febrile seizures (HP:0002373)3.05276144
36Status epilepticus (HP:0002133)2.94648675
37Onion bulb formation (HP:0003383)2.87162799
38Urinary bladder sphincter dysfunction (HP:0002839)2.86840290
39Impaired vibration sensation in the lower limbs (HP:0002166)2.85329249
40Urinary urgency (HP:0000012)2.72891633
41Postural instability (HP:0002172)2.72022777
42Pheochromocytoma (HP:0002666)2.68169287
43Sleep apnea (HP:0010535)2.66213579
44Megalencephaly (HP:0001355)2.64709167
45Anxiety (HP:0000739)2.64253466
46Truncal ataxia (HP:0002078)2.62735365
47Poor eye contact (HP:0000817)2.62257836
48Lower limb muscle weakness (HP:0007340)2.57428543
49Cerebral hypomyelination (HP:0006808)2.57023762
50Abnormal eating behavior (HP:0100738)2.54692461
51Depression (HP:0000716)2.51752225
52Akinesia (HP:0002304)2.50088071
53Apathy (HP:0000741)2.49850615
54Insomnia (HP:0100785)2.47298218
55Generalized myoclonic seizures (HP:0002123)2.45352539
56Impaired smooth pursuit (HP:0007772)2.40723001
57Progressive inability to walk (HP:0002505)2.39014876
58Impaired social interactions (HP:0000735)2.38761915
59Abnormal social behavior (HP:0012433)2.38761915
60Abnormality of the lower motor neuron (HP:0002366)2.37448668
61Thickened helices (HP:0000391)2.36182830
62Clumsiness (HP:0002312)2.36177511
63Abnormal auditory evoked potentials (HP:0006958)2.33994173
64Retinal dysplasia (HP:0007973)2.33413112
65Rapidly progressive (HP:0003678)2.31467450
66Neuroendocrine neoplasm (HP:0100634)2.30589877
67Torticollis (HP:0000473)2.26969016
68Increased circulating renin level (HP:0000848)2.25699591
69Clonus (HP:0002169)2.24397003
70Mutism (HP:0002300)2.22242088
71Diminished motivation (HP:0000745)2.22111609
72Aplasia involving bones of the upper limbs (HP:0009823)2.21288857
73Aplasia of the phalanges of the hand (HP:0009802)2.21288857
74Aplasia involving bones of the extremities (HP:0009825)2.21288857
75Alacrima (HP:0000522)2.19757784
76Parakeratosis (HP:0001036)2.17780181
77Ventricular fibrillation (HP:0001663)2.17605106
78Bundle branch block (HP:0011710)2.17576412
79Abnormality of ocular smooth pursuit (HP:0000617)2.16711786
80Hemiparesis (HP:0001269)2.13355571
81Abnormality of saccadic eye movements (HP:0000570)2.12570582
82Hypsarrhythmia (HP:0002521)2.12494174
83Slow saccadic eye movements (HP:0000514)2.12477523
84Drooling (HP:0002307)2.07107421
85Excessive salivation (HP:0003781)2.07107421
86Spastic tetraparesis (HP:0001285)2.06806862
87Focal dystonia (HP:0004373)2.06706804
88Fetal akinesia sequence (HP:0001989)2.06028491
89Neuronal loss in central nervous system (HP:0002529)2.05762685
90Amblyopia (HP:0000646)2.05097768
91Lower limb amyotrophy (HP:0007210)2.03816261
92Diplopia (HP:0000651)2.02962331
93Abnormality of binocular vision (HP:0011514)2.02962331
94Cerebral hemorrhage (HP:0001342)2.02898305
95Blue irides (HP:0000635)2.01352418
96Absent speech (HP:0001344)2.00454930
97Limb dystonia (HP:0002451)2.00261368
98Lower limb asymmetry (HP:0100559)1.98148876
99Impaired vibratory sensation (HP:0002495)1.97770098
100Split foot (HP:0001839)1.97238353
101Incomplete penetrance (HP:0003829)1.96835918
102Bradykinesia (HP:0002067)1.92787531
103Bronchomalacia (HP:0002780)1.92032793
104Rigidity (HP:0002063)1.91292623
105Polyphagia (HP:0002591)1.89942628
106Bowel incontinence (HP:0002607)1.89704842
107CNS hypomyelination (HP:0003429)1.88997654
108Craniofacial dystonia (HP:0012179)1.88645751
109Epileptiform EEG discharges (HP:0011182)1.88255319
110Papilledema (HP:0001085)1.87013633
111Abnormality of the periventricular white matter (HP:0002518)1.86888968
112Leukodystrophy (HP:0002415)1.85954255
113Memory impairment (HP:0002354)1.85560249
114Gait ataxia (HP:0002066)1.84272506
115Metabolic alkalosis (HP:0200114)1.84094673
116Heart block (HP:0012722)1.83898749
117Spinal canal stenosis (HP:0003416)1.83432725
118Stereotypic behavior (HP:0000733)1.81861486
119Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80004823
120Poor speech (HP:0002465)1.79707375
121EEG with generalized epileptiform discharges (HP:0011198)1.78564967
122Psychosis (HP:0000709)1.76857338
123Delusions (HP:0000746)1.76843532
124Dysmetric saccades (HP:0000641)1.76380709
125Distal upper limb amyotrophy (HP:0007149)1.75389282
126Choreoathetosis (HP:0001266)1.74835448
127Hammertoe (HP:0001765)1.73718714
128Morphological abnormality of the pyramidal tract (HP:0002062)1.72925487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.17431900
2STK393.69715909
3OXSR13.26003888
4NTRK33.11292145
5CDK192.67902849
6MAP3K92.65693468
7TNIK2.36858992
8PAK62.30757336
9NTRK12.09710653
10MAP3K42.07796505
11DAPK22.07580243
12CASK1.91521670
13MARK11.86841833
14PRPF4B1.85067532
15MINK11.77805635
16KSR21.75539922
17RIPK11.72248307
18UHMK11.70004480
19LATS21.64290027
20MAP2K71.63365021
21PNCK1.61299510
22PRKD31.56414339
23NTRK21.51982899
24BCR1.49308410
25TYRO31.47656570
26NEK61.45373708
27PKN11.44721232
28WNK41.42908158
29FGFR21.41726841
30* CDK51.40675345
31CAMK2B1.39727830
32MAPKAPK51.36873890
33ARAF1.36418549
34WNK11.35831687
35RIPK41.34480809
36MAP2K41.26961299
37SGK4941.24556911
38SGK2231.24556911
39MAP3K131.23979815
40CAMKK11.16497963
41FES1.14439648
42CAMK2A1.09805745
43FGR1.09031631
44EPHB11.08976600
45MAP3K121.07765364
46ROCK21.06460442
47PLK21.02494838
48CAMK2D1.01125631
49MAP3K21.00999005
50MAPK130.99608965
51CDK140.99295641
52CDK150.98135460
53GRK50.97257310
54CSNK1G20.97227513
55SGK20.96531886
56CDK180.96194353
57MAPK120.93317802
58KSR10.90958413
59MET0.90215542
60PAK30.89082141
61SGK30.87074809
62PRKCG0.86603496
63STK110.86539840
64ICK0.86144167
65CDK11A0.85989128
66CAMK2G0.85908952
67PDPK10.85719453
68PRKCH0.82650021
69PTK2B0.80296791
70CSNK1G30.80156691
71CAMKK20.79893368
72BRSK10.78076744
73PINK10.77189437
74MARK20.75265549
75PHKG10.73480043
76PHKG20.73480043
77LIMK10.73281662
78PDK10.72826919
79CSNK1A1L0.71877679
80BMPR20.71718688
81CAMK10.71249810
82DAPK10.71101380
83CAMK40.69937909
84MAP3K110.65302434
85RAF10.65251659
86PRKCE0.61474655
87PRKCQ0.60198985
88FYN0.59524696
89DMPK0.59373544
90SGK10.57937618
91STK380.56646500
92RET0.56009305
93CLK10.55373481
94BRAF0.54943562
95MUSK0.51774860
96LMTK20.51255546
97CSNK1G10.48802823
98CAMK1G0.48197252
99DAPK30.45428574
100PRKCZ0.45252190
101DYRK1A0.43742321
102MAP3K10.42580466
103PRKD10.41287509
104MAPK100.40296788
105TNK20.39993918
106RPS6KA30.39440085
107TESK10.38290778
108PRKG10.37302393
109MAP3K70.36948095
110PRKG20.36790689
111IRAK20.36633349
112ALK0.35764283
113CSNK1A10.35405998
114PRKCA0.34435165
115ROCK10.34091934
116SIK20.33620622
117ERBB20.30439390
118MAPK80.26973835
119SRC0.26463410
120PRKCB0.24609903
121JAK20.23823723
122MAP2K60.23750233

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17839627
2Synaptic vesicle cycle_Homo sapiens_hsa047212.87973446
3GABAergic synapse_Homo sapiens_hsa047272.70709329
4Glutamatergic synapse_Homo sapiens_hsa047242.62896133
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53983418
6Circadian entrainment_Homo sapiens_hsa047132.43343435
7Morphine addiction_Homo sapiens_hsa050322.42281144
8Olfactory transduction_Homo sapiens_hsa047402.29293198
9Long-term potentiation_Homo sapiens_hsa047202.23882046
10Amphetamine addiction_Homo sapiens_hsa050312.10544227
11Salivary secretion_Homo sapiens_hsa049702.05223406
12Dopaminergic synapse_Homo sapiens_hsa047281.92367734
13Nitrogen metabolism_Homo sapiens_hsa009101.85616142
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84267877
15Gastric acid secretion_Homo sapiens_hsa049711.81799052
16Serotonergic synapse_Homo sapiens_hsa047261.77256969
17Cholinergic synapse_Homo sapiens_hsa047251.75999981
18Long-term depression_Homo sapiens_hsa047301.75502390
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65666753
20Collecting duct acid secretion_Homo sapiens_hsa049661.63066716
21Insulin secretion_Homo sapiens_hsa049111.58254951
22Cocaine addiction_Homo sapiens_hsa050301.54945627
23Renin secretion_Homo sapiens_hsa049241.52385566
24Axon guidance_Homo sapiens_hsa043601.52050865
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.48540052
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43805536
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43086378
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42963981
29Taste transduction_Homo sapiens_hsa047421.42270997
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33684751
31Calcium signaling pathway_Homo sapiens_hsa040201.33470779
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33091862
33Fatty acid elongation_Homo sapiens_hsa000621.31480832
34Ether lipid metabolism_Homo sapiens_hsa005651.30873943
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26434621
36Steroid biosynthesis_Homo sapiens_hsa001001.23029287
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19687012
38Gap junction_Homo sapiens_hsa045401.18533568
39GnRH signaling pathway_Homo sapiens_hsa049121.18437857
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17686996
41cAMP signaling pathway_Homo sapiens_hsa040241.15130259
42Vibrio cholerae infection_Homo sapiens_hsa051101.13571937
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05717822
44ErbB signaling pathway_Homo sapiens_hsa040121.04864421
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.04653051
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04256821
47Cardiac muscle contraction_Homo sapiens_hsa042601.02961757
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.98891616
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96245795
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95846384
51Pancreatic secretion_Homo sapiens_hsa049720.93396929
52Histidine metabolism_Homo sapiens_hsa003400.92747163
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85854754
54Dorso-ventral axis formation_Homo sapiens_hsa043200.85718505
55Estrogen signaling pathway_Homo sapiens_hsa049150.83862373
56Oxidative phosphorylation_Homo sapiens_hsa001900.82474515
57Type II diabetes mellitus_Homo sapiens_hsa049300.82214480
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81446490
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81418053
60Phototransduction_Homo sapiens_hsa047440.80548574
61Melanogenesis_Homo sapiens_hsa049160.80223547
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.79102858
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78553307
64Renal cell carcinoma_Homo sapiens_hsa052110.77629290
65Alzheimers disease_Homo sapiens_hsa050100.77563447
66Butanoate metabolism_Homo sapiens_hsa006500.75833776
67Glioma_Homo sapiens_hsa052140.73892067
68Ras signaling pathway_Homo sapiens_hsa040140.73567763
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72988686
70Choline metabolism in cancer_Homo sapiens_hsa052310.71652649
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.71540734
72Endocytosis_Homo sapiens_hsa041440.71265111
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69601022
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69187361
75Arginine and proline metabolism_Homo sapiens_hsa003300.66467249
76MAPK signaling pathway_Homo sapiens_hsa040100.61780367
77Thyroid hormone synthesis_Homo sapiens_hsa049180.61299012
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60851356
79Glucagon signaling pathway_Homo sapiens_hsa049220.60602385
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58411371
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57790691
82Vitamin B6 metabolism_Homo sapiens_hsa007500.57502437
83Dilated cardiomyopathy_Homo sapiens_hsa054140.55850074
84Ovarian steroidogenesis_Homo sapiens_hsa049130.54945867
85Circadian rhythm_Homo sapiens_hsa047100.54860909
86Tight junction_Homo sapiens_hsa045300.54757202
87beta-Alanine metabolism_Homo sapiens_hsa004100.53087239
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.52884097
89Arginine biosynthesis_Homo sapiens_hsa002200.52253006
90Sphingolipid metabolism_Homo sapiens_hsa006000.52109946
91Parkinsons disease_Homo sapiens_hsa050120.51490528
92Inositol phosphate metabolism_Homo sapiens_hsa005620.49281917
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48064480
94Oocyte meiosis_Homo sapiens_hsa041140.47262765
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46343198
96Rap1 signaling pathway_Homo sapiens_hsa040150.45851921
97VEGF signaling pathway_Homo sapiens_hsa043700.44442752
98Rheumatoid arthritis_Homo sapiens_hsa053230.43470317
99Sulfur metabolism_Homo sapiens_hsa009200.42944968
100Bile secretion_Homo sapiens_hsa049760.42931428
101Mineral absorption_Homo sapiens_hsa049780.40501434
102Alcoholism_Homo sapiens_hsa050340.40048718
103Prion diseases_Homo sapiens_hsa050200.39959413
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39060352
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38628063
106Fatty acid biosynthesis_Homo sapiens_hsa000610.38543527
107mTOR signaling pathway_Homo sapiens_hsa041500.34447847
108Chemokine signaling pathway_Homo sapiens_hsa040620.33896803
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33515314
110Insulin signaling pathway_Homo sapiens_hsa049100.31356347
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31055872
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30962436
113Wnt signaling pathway_Homo sapiens_hsa043100.29083716
114African trypanosomiasis_Homo sapiens_hsa051430.29059080
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29015720
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28325696
117AMPK signaling pathway_Homo sapiens_hsa041520.28267956
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27993016
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23944142
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20808720
121HIF-1 signaling pathway_Homo sapiens_hsa040660.20047057
122Endometrial cancer_Homo sapiens_hsa052130.18551384

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