TPPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.71710436
2reproduction (GO:0000003)9.49904491
3axonemal dynein complex assembly (GO:0070286)9.41774987
4motile cilium assembly (GO:0044458)9.29943399
5regulation of cilium movement (GO:0003352)8.61310859
6cilium or flagellum-dependent cell motility (GO:0001539)8.30655029
7cilium movement (GO:0003341)7.74426383
8negative regulation of inclusion body assembly (GO:0090084)7.65721801
9protein targeting to Golgi (GO:0000042)7.48192067
10single fertilization (GO:0007338)7.45289982
11rRNA methylation (GO:0031167)7.35951260
12sperm capacitation (GO:0048240)7.28707585
13establishment of protein localization to Golgi (GO:0072600)7.16628759
14response to pheromone (GO:0019236)7.15380967
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04781775
16retrograde transport, vesicle recycling within Golgi (GO:0000301)6.97235185
17spermatogenesis (GO:0007283)6.95439010
18male gamete generation (GO:0048232)6.92845076
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.92407720
20organic cation transport (GO:0015695)6.91727564
21synaptonemal complex organization (GO:0070193)6.84429576
22synaptonemal complex assembly (GO:0007130)6.70710095
23microtubule depolymerization (GO:0007019)6.68341889
24male meiosis (GO:0007140)6.61206138
25phosphatidylethanolamine metabolic process (GO:0046337)6.38339325
26piRNA metabolic process (GO:0034587)6.36883539
27gamete generation (GO:0007276)6.36374016
28regulation of inclusion body assembly (GO:0090083)6.34902403
29fertilization (GO:0009566)6.28633468
30rRNA modification (GO:0000154)6.19502318
31centriole replication (GO:0007099)6.06020812
32calcium ion-dependent exocytosis (GO:0017156)5.82757841
33chromosome condensation (GO:0030261)5.77753237
34spermatid nucleus differentiation (GO:0007289)5.60064486
35germ cell development (GO:0007281)5.48269148
36protein localization to Golgi apparatus (GO:0034067)5.46780803
37glycerol ether metabolic process (GO:0006662)5.46076496
38DNA packaging (GO:0006323)5.42516815
39cellular process involved in reproduction in multicellular organism (GO:0022412)5.37685976
40cellular ketone body metabolic process (GO:0046950)5.37638161
41centriole assembly (GO:0098534)5.34331887
42regulation of microtubule-based movement (GO:0060632)5.11814400
43regulation of centriole replication (GO:0046599)5.06893942
44cell recognition (GO:0008037)5.06445027
45ether metabolic process (GO:0018904)5.04819475
46sexual reproduction (GO:0019953)5.04553009
47ventricular system development (GO:0021591)5.03775153
48multicellular organismal reproductive process (GO:0048609)5.01809998
49ketone body metabolic process (GO:1902224)4.73617118
50regulation of Rab GTPase activity (GO:0032313)4.72858325
51positive regulation of Rab GTPase activity (GO:0032851)4.72858325
52single strand break repair (GO:0000012)4.59415413
53seminiferous tubule development (GO:0072520)4.57185008
54chromosome organization involved in meiosis (GO:0070192)4.53947115
55male meiosis I (GO:0007141)4.53939575
56microtubule severing (GO:0051013)4.50729961
57regulation of transcription involved in cell fate commitment (GO:0060850)4.31289309
58chaperone-mediated protein complex assembly (GO:0051131)4.29400123
59glomerular visceral epithelial cell development (GO:0072015)4.10473707
60DNA methylation involved in gamete generation (GO:0043046)4.09705016
61left/right pattern formation (GO:0060972)4.09384455
62multicellular organismal development (GO:0007275)4.03248018
63meiotic nuclear division (GO:0007126)3.96270602
64microtubule nucleation (GO:0007020)3.92732457
65glomerular epithelial cell development (GO:0072310)3.89743961
66musculoskeletal movement (GO:0050881)3.89359134
67multicellular organismal movement (GO:0050879)3.89359134
68sequestering of actin monomers (GO:0042989)3.60967352
69meiosis I (GO:0007127)3.59007491
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56405327
71genitalia morphogenesis (GO:0035112)3.48592177
72nucleosome disassembly (GO:0006337)3.42965876
73protein-DNA complex disassembly (GO:0032986)3.42965876
74microtubule polymerization or depolymerization (GO:0031109)3.42700426
75protein K11-linked deubiquitination (GO:0035871)3.42379829
76protein refolding (GO:0042026)3.42168339
77glycolytic process (GO:0006096)3.39599373
78regulation of spindle checkpoint (GO:0090231)3.39487012
79response to acidic pH (GO:0010447)3.36629870
80coenzyme catabolic process (GO:0009109)3.35762834
81cellular response to pH (GO:0071467)3.33692424
82protein polyglutamylation (GO:0018095)3.31321894
83negative regulation of Rho protein signal transduction (GO:0035024)3.29838493
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22241798
85nucleus organization (GO:0006997)3.21578884
86homeostasis of number of cells within a tissue (GO:0048873)3.17526821
87regulation of interleukin-13 production (GO:0032656)3.15354764
88cerebral cortex neuron differentiation (GO:0021895)3.14393214
89amino-acid betaine transport (GO:0015838)3.13746363
90carnitine transport (GO:0015879)3.13746363
91meiotic cell cycle (GO:0051321)3.11534196
92polyamine biosynthetic process (GO:0006596)3.07561413
93nuclear pore complex assembly (GO:0051292)3.05918676
94peptidyl-threonine dephosphorylation (GO:0035970)3.05886168
95mitotic sister chromatid cohesion (GO:0007064)3.05572404
96positive regulation of macrophage activation (GO:0043032)3.05318164
97histone H3-K9 demethylation (GO:0033169)3.03073355
98monoubiquitinated protein deubiquitination (GO:0035520)3.02374118
99polyol catabolic process (GO:0046174)3.01712275
100negative regulation of gene expression, epigenetic (GO:0045814)3.00526272
101nucleoside diphosphate phosphorylation (GO:0006165)2.99532427
102protein depolymerization (GO:0051261)2.97912684
103interferon-gamma secretion (GO:0072643)2.95047077
104regulation of T-helper 2 cell differentiation (GO:0045628)2.94619170
105carnitine transmembrane transport (GO:1902603)2.92794118
106alditol metabolic process (GO:0019400)2.92355592
107chromatin silencing (GO:0006342)2.89998416
108mitochondrial fission (GO:0000266)2.87321975
109centrosome duplication (GO:0051298)2.86831461
110histone mRNA catabolic process (GO:0071044)2.86565991
111DNA conformation change (GO:0071103)2.85316591
112regulation of phosphoprotein phosphatase activity (GO:0043666)2.85178586
113RNA localization (GO:0006403)2.84936450
114RNA destabilization (GO:0050779)2.82642921
115protein localization to cilium (GO:0061512)2.81703308
116intra-Golgi vesicle-mediated transport (GO:0006891)2.78830571
117positive regulation of guanylate cyclase activity (GO:0031284)2.76603933
118GTP biosynthetic process (GO:0006183)2.72755624
119positive regulation of glycolytic process (GO:0045821)2.70185815
120regulation of cilium assembly (GO:1902017)2.69315543
121mitochondrion degradation (GO:0000422)2.68094829
122cilium organization (GO:0044782)2.64161735
123meiotic cell cycle process (GO:1903046)2.62669877
124synapsis (GO:0007129)2.62495761
125microtubule-based movement (GO:0007018)2.55097519
126cellular component assembly involved in morphogenesis (GO:0010927)2.54543234
127cilium assembly (GO:0042384)2.54084949
128cilium morphogenesis (GO:0060271)2.45826608
129UTP biosynthetic process (GO:0006228)2.44766591
130membrane protein intracellular domain proteolysis (GO:0031293)2.44538237
131glycerol metabolic process (GO:0006071)2.39980416
132lactate metabolic process (GO:0006089)2.37909529
133axoneme assembly (GO:0035082)2.37776865
134peptidyl-glutamic acid modification (GO:0018200)2.34689638
135sperm motility (GO:0030317)14.6563667
136cell wall macromolecule catabolic process (GO:0016998)13.5452906
137cell wall macromolecule metabolic process (GO:0044036)13.5452906
138fusion of sperm to egg plasma membrane (GO:0007342)13.4877821
139acrosome reaction (GO:0007340)12.6800832
140sperm-egg recognition (GO:0035036)11.6622243
141acrosome assembly (GO:0001675)11.4344882
142multicellular organism reproduction (GO:0032504)10.7714777
143binding of sperm to zona pellucida (GO:0007339)10.6231157
144cell-cell recognition (GO:0009988)10.4495378
145plasma membrane fusion (GO:0045026)10.2925429
146spermatid development (GO:0007286)10.0057856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.77466839
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33929031
3EZH2_22144423_ChIP-Seq_EOC_Human4.14582619
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.08712082
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73734812
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.34313173
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23030211
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89389962
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67520407
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60365777
11VDR_22108803_ChIP-Seq_LS180_Human2.58141908
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46136111
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25720954
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20731208
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.19923305
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17834781
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10180675
18FUS_26573619_Chip-Seq_HEK293_Human2.07271545
19ZNF274_21170338_ChIP-Seq_K562_Hela1.98890374
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.98627365
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95405327
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.89414413
23RAC3_21632823_ChIP-Seq_H3396_Human1.89389049
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.85971295
25DROSHA_22980978_ChIP-Seq_HELA_Human1.84659553
26ERA_21632823_ChIP-Seq_H3396_Human1.84071147
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.78953780
28STAT1_17558387_ChIP-Seq_HELA_Human1.75672171
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74961764
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73366996
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.72989766
32CTCF_27219007_Chip-Seq_Bcells_Human1.71578540
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70235575
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67868273
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.67706748
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62898637
37ER_23166858_ChIP-Seq_MCF-7_Human1.62508417
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.62155086
39MYC_19829295_ChIP-Seq_ESCs_Human1.59350310
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.58638948
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57623604
42TAF2_19829295_ChIP-Seq_ESCs_Human1.57531183
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.56652427
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56208254
45AR_25329375_ChIP-Seq_VCAP_Human1.55627820
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54796916
47KDM2B_26808549_Chip-Seq_REH_Human1.52357923
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52017822
49BCL6_27268052_Chip-Seq_Bcells_Human1.50902539
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.50738033
51OCT4_20526341_ChIP-Seq_ESCs_Human1.48571853
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.47326521
53SMC4_20622854_ChIP-Seq_HELA_Human1.46064753
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45957228
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45882058
56RBPJ_21746931_ChIP-Seq_IB4_Human1.45199247
57CBX2_22325352_ChIP-Seq_293T-Rex_Human1.44884620
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44684671
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.44439399
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44015146
61TP63_22573176_ChIP-Seq_HFKS_Human1.41291161
62PHF8_20622854_ChIP-Seq_HELA_Human1.41061394
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40076990
64CBP_20019798_ChIP-Seq_JUKART_Human1.40076990
65E2F1_20622854_ChIP-Seq_HELA_Human1.39661709
66P53_21459846_ChIP-Seq_SAOS-2_Human1.39658822
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38839432
68P68_20966046_ChIP-Seq_HELA_Human1.38411369
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37563204
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.36701040
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36634006
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.35431595
73ETV1_20927104_ChIP-Seq_GIST48_Human1.35377430
74REST_21632747_ChIP-Seq_MESCs_Mouse1.34165607
75TP53_18474530_ChIP-ChIP_U2OS_Human1.32498788
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32369763
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32205332
78P300_19829295_ChIP-Seq_ESCs_Human1.32080354
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.31925506
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31075515
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28369467
82CEBPB_22108803_ChIP-Seq_LS180_Human1.28317600
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.28138594
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27973023
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26816870
86P300_27268052_Chip-Seq_Bcells_Human1.25624048
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25185940
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24902868
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24575240
90GF1_26923725_Chip-Seq_HPCs_Mouse1.23835011
91CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23472977
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23432112
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22882968
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.22734246
95TBL1_22424771_ChIP-Seq_293T_Human1.22156089
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21717152
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.21155039
98PHF8_20622853_ChIP-Seq_HELA_Human1.20919653
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20661478
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20661478
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20188457
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19974034
103LXR_22292898_ChIP-Seq_THP-1_Human1.19581061
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19015695
105GATA6_21074721_ChIP-Seq_CACO-2_Human1.18275160
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.18234438
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.17539092
108SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17197719
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16499877
110TAF15_26573619_Chip-Seq_HEK293_Human1.16127504
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15553824
112RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14872527
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14776880
114SPI1_26923725_Chip-Seq_HPCs_Mouse1.13949749
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13746023
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13630643
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.11167092
118ERG_20517297_ChIP-Seq_VCAP_Human1.09371182
119JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09173470
120GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08925227
121SA1_27219007_Chip-Seq_Bcells_Human1.08873941
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.08306651
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07910733
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07865552
125ESET_19884257_ChIP-Seq_ESCs_Mouse1.07503541
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07473009
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07426884
128NFYA_21822215_ChIP-Seq_K562_Human1.07357994
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07252161
130NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07185018
131SMAD4_21799915_ChIP-Seq_A2780_Human1.06856451
132RUNX2_22187159_ChIP-Seq_PCA_Human1.05606773
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.04458452
134SMRT_27268052_Chip-Seq_Bcells_Human1.04316143
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03862317
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.03468860
137STAT3_23295773_ChIP-Seq_U87_Human1.03441898
138* MYC_27129775_Chip-Seq_CORNEA_Mouse1.03160401
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03039710
140RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02323294
141SOX2_19829295_ChIP-Seq_ESCs_Human1.01764304
142NANOG_19829295_ChIP-Seq_ESCs_Human1.01764304
143AR_21572438_ChIP-Seq_LNCaP_Human1.01700020
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01478008
145NANOG_18555785_Chip-Seq_ESCs_Mouse1.01433972
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.01141256
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01073198
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00683343
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98635884
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98331522
151CTCF_20526341_ChIP-Seq_ESCs_Human0.97712882
152SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95537412
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95522193
154NFYB_21822215_ChIP-Seq_K562_Human0.95440741
155LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94838717
156OCT4_18555785_Chip-Seq_ESCs_Mouse0.93069974
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92806304
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.92585858
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.91972730
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91835979
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91833751
162P53_22387025_ChIP-Seq_ESCs_Mouse0.91290266
163SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90687183
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.89997115
165BCOR_27268052_Chip-Seq_Bcells_Human0.89954414
166NANOG_20526341_ChIP-Seq_ESCs_Human0.89810109
167OCT1_27270436_Chip-Seq_PROSTATE_Human0.89395580
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87789340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08999886
2MP0001929_abnormal_gametogenesis5.50480568
3MP0008877_abnormal_DNA_methylation3.74725344
4MP0001348_abnormal_lacrimal_gland3.37561249
5MP0002161_abnormal_fertility/fecundity3.32737958
6MP0002210_abnormal_sex_determination3.24404086
7MP0005670_abnormal_white_adipose3.18696262
8MP0001145_abnormal_male_reproductive2.76310688
9MP0000653_abnormal_sex_gland2.38291784
10MP0000678_abnormal_parathyroid_gland2.19178480
11MP0003718_maternal_effect2.18648970
12MP0005410_abnormal_fertilization16.7873791
13MP0002653_abnormal_ependyma_morphology1.97598500
14MP0002132_abnormal_respiratory_system1.83116830
15MP0001485_abnormal_pinna_reflex1.75313496
16MP0005451_abnormal_body_composition1.63041171
17MP0002138_abnormal_hepatobiliary_system1.55617137
18MP0002249_abnormal_larynx_morphology1.54019769
19MP0001486_abnormal_startle_reflex1.52098794
20MP0004233_abnormal_muscle_weight1.49713592
21MP0005310_abnormal_salivary_gland1.49033195
22MP0005379_endocrine/exocrine_gland_phen1.47550151
23MP0003646_muscle_fatigue1.47293090
24MP0005248_abnormal_Harderian_gland1.44725202
25MP0005423_abnormal_somatic_nervous1.43331481
26MP0009053_abnormal_anal_canal1.39854809
27MP0002160_abnormal_reproductive_system1.38081688
28MP0001765_abnormal_ion_homeostasis1.22967092
29MP0005623_abnormal_meninges_morphology1.22065906
30MP0002282_abnormal_trachea_morphology1.09383749
31MP0001963_abnormal_hearing_physiology1.07686704
32MP0004859_abnormal_synaptic_plasticity1.02142822
33MP0002234_abnormal_pharynx_morphology1.02059280
34MP0001984_abnormal_olfaction0.99382345
35MP0005395_other_phenotype0.98755451
36MP0002735_abnormal_chemical_nociception0.96488770
37MP0002822_catalepsy0.94602309
38MP0005647_abnormal_sex_gland0.93795799
39MP0000026_abnormal_inner_ear0.93071441
40MP0002127_abnormal_cardiovascular_syste0.92786777
41MP0004510_myositis0.90324585
42MP0000955_abnormal_spinal_cord0.79031937
43MP0005636_abnormal_mineral_homeostasis0.75535775
44MP0002067_abnormal_sensory_capabilities0.74718252
45MP0005666_abnormal_adipose_tissue0.74207663
46MP0008995_early_reproductive_senescence0.73009826
47MP0003115_abnormal_respiratory_system0.70359190
48MP0001666_abnormal_nutrient_absorption0.69617501
49MP0008058_abnormal_DNA_repair0.68400860
50MP0000566_synostosis0.67854330
51MP0005083_abnormal_biliary_tract0.67829689
52MP0009697_abnormal_copulation0.67823744
53MP0005389_reproductive_system_phenotype0.66715584
54MP0009046_muscle_twitch0.64008622
55MP0004036_abnormal_muscle_relaxation0.63852703
56MP0000049_abnormal_middle_ear0.62810077
57MP0002557_abnormal_social/conspecific_i0.61970755
58MP0003878_abnormal_ear_physiology0.61536887
59MP0005377_hearing/vestibular/ear_phenot0.61536887
60MP0005167_abnormal_blood-brain_barrier0.60507800
61MP0003011_delayed_dark_adaptation0.58838861
62MP0004085_abnormal_heartbeat0.57524446
63MP0000681_abnormal_thyroid_gland0.56674075
64MP0002269_muscular_atrophy0.55192630
65MP0001879_abnormal_lymphatic_vessel0.55148173
66MP0001764_abnormal_homeostasis0.54981861
67MP0001905_abnormal_dopamine_level0.53534333
68MP0006292_abnormal_olfactory_placode0.52958868
69MP0001324_abnormal_eye_pigmentation0.52879891
70MP0003329_amyloid_beta_deposits0.52671102
71MP0002736_abnormal_nociception_after0.50104733
72MP0005084_abnormal_gallbladder_morpholo0.49732054
73MP0002572_abnormal_emotion/affect_behav0.48107941
74MP0005408_hypopigmentation0.47604255
75MP0003077_abnormal_cell_cycle0.47494783
76MP0000358_abnormal_cell_content/0.47044418
77MP0003699_abnormal_female_reproductive0.45642428
78MP0000613_abnormal_salivary_gland0.45569703
79MP0002733_abnormal_thermal_nociception0.44438206
80MP0006036_abnormal_mitochondrial_physio0.43120354
81MP0000534_abnormal_ureter_morphology0.42051954
82MP0002272_abnormal_nervous_system0.41719059
83MP0005332_abnormal_amino_acid0.41502555
84MP0004484_altered_response_of0.40487611
85MP0000516_abnormal_urinary_system0.39962120
86MP0005367_renal/urinary_system_phenotyp0.39962120
87MP0002139_abnormal_hepatobiliary_system0.39175221
88MP0000230_abnormal_systemic_arterial0.38959035
89MP0009745_abnormal_behavioral_response0.38566856
90MP0009115_abnormal_fat_cell0.38527212
91MP0003137_abnormal_impulse_conducting0.37858093
92MP0005397_hematopoietic_system_phenotyp0.37627370
93MP0001545_abnormal_hematopoietic_system0.37627370
94MP0004145_abnormal_muscle_electrophysio0.37428947
95MP0001440_abnormal_grooming_behavior0.36956833
96MP0002928_abnormal_bile_duct0.36594155
97MP0005551_abnormal_eye_electrophysiolog0.35510274
98MP0003950_abnormal_plasma_membrane0.35455010
99MP0001293_anophthalmia0.35237624
100MP0002971_abnormal_brown_adipose0.35233060
101MP0009278_abnormal_bone_marrow0.35074347
102MP0001501_abnormal_sleep_pattern0.33845783
103MP0005253_abnormal_eye_physiology0.33708588
104MP0000003_abnormal_adipose_tissue0.33493460
105MP0002734_abnormal_mechanical_nocicepti0.32919654
106MP0003936_abnormal_reproductive_system0.32272754
107MP0002932_abnormal_joint_morphology0.32130731
108MP0000604_amyloidosis0.29175058
109MP0001849_ear_inflammation0.29157582
110MP0003942_abnormal_urinary_system0.28500887
111MP0001968_abnormal_touch/_nociception0.28384339
112MP0005365_abnormal_bile_salt0.27700564
113MP0003633_abnormal_nervous_system0.27360378
114MP0000569_abnormal_digit_pigmentation0.27222164
115MP0000751_myopathy0.27078865
116MP0006035_abnormal_mitochondrial_morpho0.26284257
117MP0001119_abnormal_female_reproductive0.26265872
118MP0004270_analgesia0.26235053
119MP0005375_adipose_tissue_phenotype0.26230386
120MP0005391_vision/eye_phenotype0.25873721
121MP0003948_abnormal_gas_homeostasis0.25865801
122MP0008875_abnormal_xenobiotic_pharmacok0.25185619
123MP0010094_abnormal_chromosome_stability0.24804688
124MP0002169_no_abnormal_phenotype0.23931062
125MP0002873_normal_phenotype0.23718335
126MP0002295_abnormal_pulmonary_circulatio0.23516428
127MP0004019_abnormal_vitamin_homeostasis0.23345183
128MP0004811_abnormal_neuron_physiology0.23269183
129MP0003879_abnormal_hair_cell0.23149658
130MP0002102_abnormal_ear_morphology0.23009370
131MP0003959_abnormal_lean_body0.22557326
132MP0004133_heterotaxia0.22404339
133MP0001986_abnormal_taste_sensitivity0.22348511
134MP0003631_nervous_system_phenotype0.22301341
135MP0002693_abnormal_pancreas_physiology0.21658026
136MP0004130_abnormal_muscle_cell0.19535287
137MP0003861_abnormal_nervous_system0.19397725
138MP0002118_abnormal_lipid_homeostasis0.19086963
139MP0004043_abnormal_pH_regulation0.18963470
140MP0005535_abnormal_body_temperature0.17967855
141MP0002152_abnormal_brain_morphology0.17782634
142MP0001730_embryonic_growth_arrest0.17722261
143MP0008569_lethality_at_weaning0.17162957
144MP0005319_abnormal_enzyme/_coenzyme0.16281279
145MP0004742_abnormal_vestibular_system0.15958071
146MP0002106_abnormal_muscle_physiology0.14313851
147MP0000001_mammalian_phenotype0.13972124
148MP0004087_abnormal_muscle_fiber0.13918381
149MP0002254_reproductive_system_inflammat0.13390308
150MP0002092_abnormal_eye_morphology0.13228302
151MP0002229_neurodegeneration0.13048054
152MP0005334_abnormal_fat_pad0.12769836
153MP0010329_abnormal_lipoprotein_level0.12748295
154MP0003111_abnormal_nucleus_morphology0.12531600
155MP0001270_distended_abdomen0.12329618
156MP0004084_abnormal_cardiac_muscle0.12194288

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.37085068
2Abnormal respiratory motile cilium morphology (HP:0005938)9.37085068
3Abnormal respiratory motile cilium physiology (HP:0012261)9.25149406
4Severe visual impairment (HP:0001141)7.60418004
5Abnormal ciliary motility (HP:0012262)7.31360413
6Rhinitis (HP:0012384)7.31100723
7Chronic bronchitis (HP:0004469)7.23552367
8Infertility (HP:0000789)7.13454364
9Nasal polyposis (HP:0100582)6.47646551
10Chronic hepatic failure (HP:0100626)5.65396964
11Abnormality of the nasal mucosa (HP:0000433)5.33561328
12Male infertility (HP:0003251)5.12878199
13Hyperkalemia (HP:0002153)4.73587445
14Attenuation of retinal blood vessels (HP:0007843)4.67832315
15Resting tremor (HP:0002322)4.66148920
16Bony spicule pigmentary retinopathy (HP:0007737)4.56554271
17Bronchitis (HP:0012387)4.54335205
18Bronchiectasis (HP:0002110)4.31756494
19Cone-rod dystrophy (HP:0000548)4.22858624
20Abnormality of macular pigmentation (HP:0008002)4.18222896
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.14816148
22Nephronophthisis (HP:0000090)3.88708409
23Hypoalphalipoproteinemia (HP:0003233)3.80136716
24Abnormal spermatogenesis (HP:0008669)3.77319734
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.66161197
26Potter facies (HP:0002009)3.62274699
27Facial shape deformation (HP:0011334)3.62274699
28Progressive sensorineural hearing impairment (HP:0000408)3.61437785
29Abnormal rod and cone electroretinograms (HP:0008323)3.45001161
30Hypoplasia of the thymus (HP:0000778)3.43761708
31Menstrual irregularities (HP:0000858)3.37108380
32Recurrent sinusitis (HP:0011108)3.33443826
33Recurrent otitis media (HP:0000403)3.19629673
34Renovascular hypertension (HP:0100817)3.19376606
35Postural instability (HP:0002172)3.15831894
36Amelogenesis imperfecta (HP:0000705)3.14957803
37Progressive cerebellar ataxia (HP:0002073)3.07924856
38Abnormality of dental color (HP:0011073)3.03844473
39Hypoplastic ischia (HP:0003175)3.03126556
40Enlarged epiphyses (HP:0010580)2.96892585
41Abnormality of the renal medulla (HP:0100957)2.91848930
42Insulin-resistant diabetes mellitus (HP:0000831)2.85197687
43Recurrent bronchitis (HP:0002837)2.74857097
44Portal hypertension (HP:0001409)2.71174973
45Abnormality of the ischium (HP:0003174)2.70626545
46Impulsivity (HP:0100710)2.70097912
47Tubulointerstitial nephritis (HP:0001970)2.69958633
48Abnormality of potassium homeostasis (HP:0011042)2.60094158
49Cholecystitis (HP:0001082)2.59551782
50Abnormal gallbladder physiology (HP:0012438)2.59551782
51Generalized aminoaciduria (HP:0002909)2.59444407
52Abnormality of the aortic arch (HP:0012303)2.58144395
53Tubular atrophy (HP:0000092)2.51158642
54Hyperuricemia (HP:0002149)2.48199147
55Increased purine levels (HP:0004368)2.48199147
56Unilateral renal agenesis (HP:0000122)2.47890375
57Abnormality of the hepatic vasculature (HP:0006707)2.47672237
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39619815
59Abnormality of midbrain morphology (HP:0002418)2.38588664
60Molar tooth sign on MRI (HP:0002419)2.38588664
61Abnormality of the costochondral junction (HP:0000919)2.38066378
62Medial flaring of the eyebrow (HP:0010747)2.36254628
63Tubulointerstitial abnormality (HP:0001969)2.35138229
64Dyschromatopsia (HP:0007641)2.31226512
65Azoospermia (HP:0000027)2.28541268
66Progressive hearing impairment (HP:0001730)2.24905679
67Hypophosphatemic rickets (HP:0004912)2.19848697
68Gonadotropin excess (HP:0000837)2.19664649
69Choroideremia (HP:0001139)2.18051741
70Focal segmental glomerulosclerosis (HP:0000097)2.16037427
71Osteomalacia (HP:0002749)2.10961780
72Ventricular tachycardia (HP:0004756)2.10391896
73Polyuria (HP:0000103)2.09664560
74Decreased central vision (HP:0007663)2.07896460
75Intellectual disability, moderate (HP:0002342)2.07067191
76Subcapsular cataract (HP:0000523)2.05963964
77Flattened epiphyses (HP:0003071)2.05253862
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03014883
79Absent epiphyses (HP:0010577)2.03014883
80Recurrent pneumonia (HP:0006532)2.02605761
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.6881379
82Absent/shortened dynein arms (HP:0200106)13.6881379
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7333383
84Optic nerve hypoplasia (HP:0000609)1.98483526
85Hypolipoproteinemia (HP:0010981)1.98203409
86Widely patent fontanelles and sutures (HP:0004492)1.94803253
87Spastic tetraparesis (HP:0001285)1.94456920
88Tubulointerstitial fibrosis (HP:0005576)1.93260634
89Abnormality of the parathyroid morphology (HP:0011766)1.92516838
90Abnormality of the epiphysis of the femoral head (HP:0010574)1.91494597
91Myokymia (HP:0002411)1.90952380
92Hyponatremia (HP:0002902)1.85162464
93Asymmetric septal hypertrophy (HP:0001670)1.83038413
94Hemorrhage of the eye (HP:0011885)1.81454706
95Abnormality of femoral epiphyses (HP:0006499)1.78124544
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78124544
97Glomerulosclerosis (HP:0000096)1.77800475
98Heterotopia (HP:0002282)1.72546270
99Flat capital femoral epiphysis (HP:0003370)1.72325013
100Double outlet right ventricle (HP:0001719)1.72263380
101Congenital malformation of the right heart (HP:0011723)1.72263380
102Recurrent corneal erosions (HP:0000495)1.71455207
103Abnormality of purine metabolism (HP:0004352)1.70929349
104Abnormality of the femoral head (HP:0003368)1.70286504
105Abnormal albumin level (HP:0012116)1.68814818
106Hypoalbuminemia (HP:0003073)1.68814818
107Abnormality of chloride homeostasis (HP:0011422)1.68650755
108Epiphyseal dysplasia (HP:0002656)1.66809414
109Polydipsia (HP:0001959)1.66761469
110Abnormal drinking behavior (HP:0030082)1.66761469
111Neurofibrillary tangles (HP:0002185)1.66667552
112Stage 5 chronic kidney disease (HP:0003774)1.66012800
113Tetany (HP:0001281)1.65888609
114Bile duct proliferation (HP:0001408)1.65312785
115Abnormal biliary tract physiology (HP:0012439)1.65312785
116Exercise-induced myalgia (HP:0003738)1.62053980
117Postaxial foot polydactyly (HP:0001830)1.60478033
118Abnormality of renal excretion (HP:0011036)1.60357507
119Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60211584
120Bundle branch block (HP:0011710)1.58508596
121Aplasia/Hypoplasia of the lens (HP:0008063)1.56225567
122Congenital hepatic fibrosis (HP:0002612)1.54774235
123Abnormality of the renal cortex (HP:0011035)1.52892600
124Fatigable weakness (HP:0003473)1.52580027
125Abnormality of the neuromuscular junction (HP:0003398)1.52580027
126Easy fatigability (HP:0003388)1.50694616
127Bell-shaped thorax (HP:0001591)1.49995428
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44193231
129Myoglobinuria (HP:0002913)1.43642910
130Short ribs (HP:0000773)1.41494925
131Sensory axonal neuropathy (HP:0003390)1.41433095
132Truncal obesity (HP:0001956)1.40532022
133Oculomotor apraxia (HP:0000657)1.38442936
134Cerebral inclusion bodies (HP:0100314)1.37521101
135Chronic sinusitis (HP:0011109)1.37122685
136Hypercholesterolemia (HP:0003124)1.36505003
137Abnormal urine output (HP:0012590)1.34930612
138Postaxial hand polydactyly (HP:0001162)1.34718292
139Abnormality of the dental root (HP:0006486)1.34282641
140Taurodontia (HP:0000679)1.34282641
141Abnormality of permanent molar morphology (HP:0011071)1.34282641
142Renal dysplasia (HP:0000110)1.33315832
143Constricted visual fields (HP:0001133)1.29883152
144Abnormality of dentin (HP:0010299)1.28848217
145Gait imbalance (HP:0002141)1.28740439
146Congenital primary aphakia (HP:0007707)1.28684839
147Rhabdomyolysis (HP:0003201)1.26789607
148Exercise-induced muscle cramps (HP:0003710)1.26221654
149Loss of speech (HP:0002371)1.26095301
150Abnormality of the dental pulp (HP:0006479)1.25831249
151Hemiparesis (HP:0001269)1.25388603
152Cystic liver disease (HP:0006706)1.24630208
153Abnormality of molar morphology (HP:0011070)1.22667890
154Abnormality of molar (HP:0011077)1.22667890
155Type 2 muscle fiber atrophy (HP:0003554)1.22640381
156Neoplasm of the heart (HP:0100544)1.22195420
157Hyporeflexia of lower limbs (HP:0002600)1.21736435
158Facial cleft (HP:0002006)1.21471224
159Fibular hypoplasia (HP:0003038)1.21071939
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20353445
161Bulbar palsy (HP:0001283)1.20008248
162Deformed sella turcica (HP:0002681)1.19845541
163Cerebellar dysplasia (HP:0007033)1.19648561
164Generalized muscle weakness (HP:0003324)1.19339225
165Abnormality of the lower motor neuron (HP:0002366)1.16723915
166Decreased muscle mass (HP:0003199)1.15580357
167Abnormality of saccadic eye movements (HP:0000570)1.15288667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.21213062
2PDK48.21213062
3TESK16.30230114
4PDK25.31337176
5PRKD35.15414238
6ICK4.66024389
7INSRR3.84414684
8DDR23.72622208
9BRD43.48625425
10PLK23.48013524
11MAP4K23.00481745
12PTK2B2.10358329
13WNK42.05621150
14PIK3CG2.01295760
15STK391.94382310
16PNCK1.81201547
17STK381.77755457
18DYRK1B1.68126696
19PDK11.39931598
20NEK21.37689596
21CAMK1D1.31428121
22CDK71.00525203
23PDPK10.94602652
24AKT30.93652147
25MAP3K90.88625325
26DYRK30.88607357
27TYRO30.85235390
28KSR20.82746548
29SIK20.82213415
30IRAK10.80040882
31MAPK150.80023971
32RIPK40.78068673
33WNK10.75496785
34PASK0.68718532
35MAP2K60.63783778
36CAMK10.61815119
37ROCK10.61496736
38LATS20.60286030
39CCNB10.59964870
40TIE10.59769705
41MUSK0.59654326
42MAP3K110.59209042
43CHEK20.58596996
44TESK20.58310359
45EEF2K0.57925321
46MAP2K20.57729229
47CAMK1G0.57486689
48RPS6KA20.55031828
49PINK10.54319654
50PRKAA20.53423291
51SGK2230.51897706
52SGK4940.51897706
53LMTK20.51731716
54STK30.49601572
55TTK0.49309620
56CDK30.49245874
57PAK10.48949379
58LATS10.46823944
59UHMK10.46186116
60IRAK20.44068957
61MAP3K80.43117505
62MAP3K20.42178088
63CAMK40.42143894
64NTRK20.41438569
65BMPR1B0.38309741
66MAPK10.37151267
67PRKCG0.36787550
68STK38L0.36318255
69NTRK30.36299904
70MAP3K100.32661064
71CHEK10.32313910
72MARK10.31857578
73PAK20.29594883
74SGK10.29300771
75MST1R0.28144790
76MARK20.27977687
77RPS6KC10.26667426
78RPS6KL10.26667426
79RPS6KA60.24760248
80CDK40.24536687
81PRKCZ0.24127502
82MAPKAPK50.23125550
83MAPK140.23027745
84MAP3K40.22439675
85ATM0.21789809
86NUAK10.20791673
87PLK40.20710741
88MTOR0.20117860
89PAK40.19483574
90CAMKK10.19160994
91MAP3K70.18745310
92SGK20.18324940
93RPS6KB10.18032608
94MAPK100.17957979
95DYRK20.16913090
96PRKAA10.16077991
97ARAF0.16000806
98NEK60.15673232
99PRKCQ0.15314147
100RPS6KA10.14622050
101CDK150.14384396
102AKT10.13634525
103MARK30.12386655
104CSF1R0.12032223
105CDK180.11542441
106TNIK0.11346446
107ATR0.10682092
108STK110.10670119
109MAPK110.10481781
110PRKG20.10416466
111CDK11A0.10260284
112OXSR10.09846208
113FER0.09573074
114BRSK20.08931548
115PIM10.08817595
116VRK10.08768864
117PKN10.07094280
118BLK0.07014129
119PRKCD0.06864665
120GSK3B0.06261685
121CDK140.06252873
122PLK10.05523316
123CSNK1D0.05405377
124CSNK2A10.05121578
125BRSK10.03680771
126PRKG10.03318451
127WEE10.03278468
128CDK60.02998781
129EGFR0.02398609
130MAP3K50.02379027
131PRKACG0.01856002
132PRKCA0.01655993
133PRKCB0.01364618
134CAMK2A0.01355743
135AURKA0.01276962
136STK100.00620367
137CSNK2A20.00358404
138CDK20.00166252
139MAPK80.00140089
140TTN-7.2125669
141CDC7-0.0346565
142YES1-0.0319241
143PRKACA-0.0278760
144MET-0.0260483
145RPS6KA3-0.0248699
146PRKACB-0.0199756
147MAP3K1-0.0174169
148MAPK4-0.0134719
149CDK1-0.0130262
150BRAF-0.0118165
151CDK12-0.0087374
152OBSCN-0.0068494

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.38399816
2Fatty acid biosynthesis_Homo sapiens_hsa000614.82055470
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.61529915
4Vitamin B6 metabolism_Homo sapiens_hsa007503.30053216
5Olfactory transduction_Homo sapiens_hsa047403.27040027
6Pyruvate metabolism_Homo sapiens_hsa006203.21506834
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.13785058
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.02154196
9Linoleic acid metabolism_Homo sapiens_hsa005912.99303579
10Butanoate metabolism_Homo sapiens_hsa006502.63379666
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.50645045
12Glucagon signaling pathway_Homo sapiens_hsa049222.48725613
13Propanoate metabolism_Homo sapiens_hsa006402.48043142
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33649793
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06108253
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.96241932
17Basal transcription factors_Homo sapiens_hsa030221.95664045
18Glycerolipid metabolism_Homo sapiens_hsa005611.94338530
19PPAR signaling pathway_Homo sapiens_hsa033201.92598224
20Selenocompound metabolism_Homo sapiens_hsa004501.84648914
21Phenylalanine metabolism_Homo sapiens_hsa003601.67499328
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.66687310
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63601886
24Fructose and mannose metabolism_Homo sapiens_hsa000511.63112406
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62412205
26Mineral absorption_Homo sapiens_hsa049781.60484785
27Fatty acid degradation_Homo sapiens_hsa000711.59370857
28Fat digestion and absorption_Homo sapiens_hsa049751.55456233
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.55309103
30Fatty acid metabolism_Homo sapiens_hsa012121.53167591
31Oocyte meiosis_Homo sapiens_hsa041141.52630973
32Carbon metabolism_Homo sapiens_hsa012001.43175226
33Pentose phosphate pathway_Homo sapiens_hsa000301.38153908
34Amphetamine addiction_Homo sapiens_hsa050311.37572628
35Ether lipid metabolism_Homo sapiens_hsa005651.34508691
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34302560
37Cardiac muscle contraction_Homo sapiens_hsa042601.30471058
38Dorso-ventral axis formation_Homo sapiens_hsa043201.29737343
39Phototransduction_Homo sapiens_hsa047441.15585221
40Arginine biosynthesis_Homo sapiens_hsa002201.14259423
41Arginine and proline metabolism_Homo sapiens_hsa003301.10743199
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09967553
43Antigen processing and presentation_Homo sapiens_hsa046121.08112126
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07456305
45Type I diabetes mellitus_Homo sapiens_hsa049401.07047847
46Renin secretion_Homo sapiens_hsa049241.06341480
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.04008951
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.02889674
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00373557
50Glutathione metabolism_Homo sapiens_hsa004801.00110977
51Collecting duct acid secretion_Homo sapiens_hsa049660.94838534
52Autoimmune thyroid disease_Homo sapiens_hsa053200.94307227
53Insulin secretion_Homo sapiens_hsa049110.94158380
54Allograft rejection_Homo sapiens_hsa053300.93676519
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92762471
56Purine metabolism_Homo sapiens_hsa002300.92035263
57Hedgehog signaling pathway_Homo sapiens_hsa043400.91285379
58Biosynthesis of amino acids_Homo sapiens_hsa012300.89327601
59Thyroid hormone synthesis_Homo sapiens_hsa049180.88977700
60Chemical carcinogenesis_Homo sapiens_hsa052040.86314815
61Arachidonic acid metabolism_Homo sapiens_hsa005900.85425359
62Bile secretion_Homo sapiens_hsa049760.85210817
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.84739908
64Morphine addiction_Homo sapiens_hsa050320.83824491
65Graft-versus-host disease_Homo sapiens_hsa053320.82557631
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82450814
67Fanconi anemia pathway_Homo sapiens_hsa034600.82323973
68Retinol metabolism_Homo sapiens_hsa008300.80998602
69Long-term potentiation_Homo sapiens_hsa047200.78076276
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73992507
71Huntingtons disease_Homo sapiens_hsa050160.73877172
72mRNA surveillance pathway_Homo sapiens_hsa030150.73130813
73Tyrosine metabolism_Homo sapiens_hsa003500.72583157
74Estrogen signaling pathway_Homo sapiens_hsa049150.71205251
75Salivary secretion_Homo sapiens_hsa049700.70257477
76Pancreatic secretion_Homo sapiens_hsa049720.66730891
77Renin-angiotensin system_Homo sapiens_hsa046140.63683816
78ABC transporters_Homo sapiens_hsa020100.62655794
79Viral myocarditis_Homo sapiens_hsa054160.61746473
80Protein digestion and absorption_Homo sapiens_hsa049740.60618487
81Sulfur metabolism_Homo sapiens_hsa009200.59163369
82Gastric acid secretion_Homo sapiens_hsa049710.59127043
83Influenza A_Homo sapiens_hsa051640.59122433
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.58960097
85Nitrogen metabolism_Homo sapiens_hsa009100.58274957
86Legionellosis_Homo sapiens_hsa051340.57148006
87Nicotine addiction_Homo sapiens_hsa050330.56415415
88Calcium signaling pathway_Homo sapiens_hsa040200.56005667
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53420859
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.53205961
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53138470
92Glutamatergic synapse_Homo sapiens_hsa047240.52534873
93RNA transport_Homo sapiens_hsa030130.50327682
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49329278
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.49203899
96Serotonergic synapse_Homo sapiens_hsa047260.48165248
97Synaptic vesicle cycle_Homo sapiens_hsa047210.45648681
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45361509
99Inositol phosphate metabolism_Homo sapiens_hsa005620.44984002
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44661626
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43467547
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43184651
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43157994
104Systemic lupus erythematosus_Homo sapiens_hsa053220.41944158
105Endocytosis_Homo sapiens_hsa041440.41801931
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41641675
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41305381
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40195233
109MAPK signaling pathway_Homo sapiens_hsa040100.38906572
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38659871
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38658853
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38624848
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38173761
114Tight junction_Homo sapiens_hsa045300.37588750
115Metabolic pathways_Homo sapiens_hsa011000.37367211
116AMPK signaling pathway_Homo sapiens_hsa041520.36835092
117GABAergic synapse_Homo sapiens_hsa047270.35113103
118Taste transduction_Homo sapiens_hsa047420.33567109
119Cholinergic synapse_Homo sapiens_hsa047250.32714203
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.30846886
121cAMP signaling pathway_Homo sapiens_hsa040240.30826896
122VEGF signaling pathway_Homo sapiens_hsa043700.30797630
123Circadian entrainment_Homo sapiens_hsa047130.28171208
124Oxytocin signaling pathway_Homo sapiens_hsa049210.24327338
125Acute myeloid leukemia_Homo sapiens_hsa052210.23512033
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18878268
127Pyrimidine metabolism_Homo sapiens_hsa002400.17365886
128Cocaine addiction_Homo sapiens_hsa050300.15761717
129Alcoholism_Homo sapiens_hsa050340.14916568
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13419397
131HIF-1 signaling pathway_Homo sapiens_hsa040660.12489148
132Salmonella infection_Homo sapiens_hsa051320.10527863
133B cell receptor signaling pathway_Homo sapiens_hsa046620.09110370
134Wnt signaling pathway_Homo sapiens_hsa043100.07737445
135Insulin resistance_Homo sapiens_hsa049310.06468685
136Basal cell carcinoma_Homo sapiens_hsa052170.04066062
137Type II diabetes mellitus_Homo sapiens_hsa049300.04048208

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