TPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.72448310
2* nuclear pore complex assembly (GO:0051292)5.65345431
3* nuclear pore organization (GO:0006999)5.35513229
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.75357870
5mitotic chromosome condensation (GO:0007076)4.51104147
6protein localization to kinetochore (GO:0034501)4.48078643
7DNA strand elongation involved in DNA replication (GO:0006271)4.24658896
8kinetochore organization (GO:0051383)4.14683084
9* pore complex assembly (GO:0046931)4.12315385
10DNA unwinding involved in DNA replication (GO:0006268)4.08783297
11non-recombinational repair (GO:0000726)4.07035640
12double-strand break repair via nonhomologous end joining (GO:0006303)4.07035640
13DNA strand elongation (GO:0022616)4.05769092
14pre-miRNA processing (GO:0031054)3.99250704
15regulation of DNA endoreduplication (GO:0032875)3.95846488
16* mitotic nuclear envelope disassembly (GO:0007077)3.91260112
17sister chromatid segregation (GO:0000819)3.85747906
18negative regulation of histone methylation (GO:0031061)3.83264170
19protein localization to chromosome, centromeric region (GO:0071459)3.80766037
20telomere maintenance via semi-conservative replication (GO:0032201)3.80104922
21mitotic metaphase plate congression (GO:0007080)3.78069194
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.75748181
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.75748181
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.75748181
25telomere maintenance via recombination (GO:0000722)3.71515052
26* membrane disassembly (GO:0030397)3.67112732
27* nuclear envelope disassembly (GO:0051081)3.67112732
28DNA synthesis involved in DNA repair (GO:0000731)3.65302320
29regulation of histone H3-K9 methylation (GO:0051570)3.64088589
30metaphase plate congression (GO:0051310)3.61124716
31DNA geometric change (GO:0032392)3.61009830
32DNA duplex unwinding (GO:0032508)3.60583716
33meiotic chromosome segregation (GO:0045132)3.58861839
34heterochromatin organization (GO:0070828)3.54130368
35positive regulation of chromosome segregation (GO:0051984)3.48171897
36monoubiquitinated protein deubiquitination (GO:0035520)3.47792732
37* regulation of RNA export from nucleus (GO:0046831)3.44759380
38regulation of sister chromatid cohesion (GO:0007063)3.43100062
39mitotic sister chromatid segregation (GO:0000070)3.42951389
40negative regulation of DNA repair (GO:0045738)3.34173355
41regulation of histone H3-K27 methylation (GO:0061085)3.33937820
42DNA ligation (GO:0006266)3.27241604
43* negative regulation of chromosome segregation (GO:0051985)3.26194310
44regulation of centriole replication (GO:0046599)3.26051454
45dosage compensation (GO:0007549)3.24889634
46sister chromatid cohesion (GO:0007062)3.24349207
47attachment of spindle microtubules to kinetochore (GO:0008608)3.22620301
48chromatin assembly (GO:0031497)3.22240079
49* regulation of mitotic sister chromatid separation (GO:0010965)3.21246429
50* regulation of mitotic sister chromatid segregation (GO:0033047)3.21246429
51* regulation of sister chromatid segregation (GO:0033045)3.21246429
52NLS-bearing protein import into nucleus (GO:0006607)3.21018790
53* mitotic spindle checkpoint (GO:0071174)3.20587013
54* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19070568
55* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19070568
56* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19070568
57* negative regulation of mitotic sister chromatid separation (GO:2000816)3.19070568
58* negative regulation of sister chromatid segregation (GO:0033046)3.19070568
59establishment of chromosome localization (GO:0051303)3.17890081
60kinetochore assembly (GO:0051382)3.13061182
61RNA stabilization (GO:0043489)3.12704258
62mRNA stabilization (GO:0048255)3.12704258
63mitotic G2/M transition checkpoint (GO:0044818)3.12449323
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10842671
65* regulation of spindle organization (GO:0090224)3.09788354
66* mitotic spindle assembly checkpoint (GO:0007094)3.08820846
67DNA conformation change (GO:0071103)3.06750099
68DNA replication-dependent nucleosome assembly (GO:0006335)3.06484454
69DNA replication-dependent nucleosome organization (GO:0034723)3.06484454
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.06335558
71chromatin assembly or disassembly (GO:0006333)3.06323543
72* spindle assembly checkpoint (GO:0071173)3.05038633
73IMP biosynthetic process (GO:0006188)3.04318222
74DNA topological change (GO:0006265)3.04237167
75glucocorticoid receptor signaling pathway (GO:0042921)3.03654453
76negative regulation of DNA-dependent DNA replication (GO:2000104)3.02974664
77regulation of centrosome cycle (GO:0046605)3.02953185
78protein localization to chromosome (GO:0034502)3.01569805
79regulation of DNA damage checkpoint (GO:2000001)3.01240115
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00755776
81histone H2A monoubiquitination (GO:0035518)2.99397306
82resolution of meiotic recombination intermediates (GO:0000712)2.97954507
83V(D)J recombination (GO:0033151)2.97186123
84DNA replication-independent nucleosome organization (GO:0034724)2.96665416
85DNA replication-independent nucleosome assembly (GO:0006336)2.96665416
86intra-S DNA damage checkpoint (GO:0031573)2.95982636
87histone mRNA catabolic process (GO:0071044)2.95758265
88establishment of integrated proviral latency (GO:0075713)2.94540568
89formation of translation preinitiation complex (GO:0001731)2.93176129
90chromatin remodeling at centromere (GO:0031055)2.91992014
91chromosome condensation (GO:0030261)2.91140150
92telomere maintenance (GO:0000723)2.90515033
93DNA replication initiation (GO:0006270)2.90094049
94* nuclear envelope organization (GO:0006998)2.88252126
95regulation of helicase activity (GO:0051095)2.87917026
96negative regulation of mRNA metabolic process (GO:1903312)2.87363158
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87194197
98telomere organization (GO:0032200)2.86815711
99ribosome assembly (GO:0042255)2.85426972
100cytoplasmic mRNA processing body assembly (GO:0033962)2.84639407
101DNA packaging (GO:0006323)2.83937246
102ATP-dependent chromatin remodeling (GO:0043044)2.83030338
103translesion synthesis (GO:0019985)2.82953105
104DNA replication checkpoint (GO:0000076)2.82919141
105CENP-A containing nucleosome assembly (GO:0034080)2.81861485
106chromosome segregation (GO:0007059)2.81452517
107regulation of centrosome duplication (GO:0010824)2.78482006
108corticosteroid receptor signaling pathway (GO:0031958)2.76452503
109negative regulation of histone modification (GO:0031057)2.76081887
110* regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75530260
111* regulation of chromosome segregation (GO:0051983)2.74182968
112IMP metabolic process (GO:0046040)2.73189512
113* spindle checkpoint (GO:0031577)2.72747384
114folic acid-containing compound biosynthetic process (GO:0009396)2.70397718
115negative regulation of chromatin modification (GO:1903309)2.69453045
116gene silencing by RNA (GO:0031047)2.69375597
117* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.67812612
118response to UV-C (GO:0010225)2.67456705
119histone exchange (GO:0043486)2.66673528
120* regulation of nucleobase-containing compound transport (GO:0032239)2.66325780
121* mRNA transport (GO:0051028)2.66151373
122mitotic DNA integrity checkpoint (GO:0044774)2.65769010
123alternative mRNA splicing, via spliceosome (GO:0000380)2.64292860
124regulation of translational fidelity (GO:0006450)2.60929432
125regulation of mRNA stability (GO:0043488)2.59193925
126histone H3-K9 methylation (GO:0051567)2.58700393
127negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.57988221
128mitotic recombination (GO:0006312)2.57561887
129paraxial mesoderm development (GO:0048339)2.56872831
130nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.55929586
131histone-serine phosphorylation (GO:0035404)2.55421973
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52202564
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.52202564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.83592649
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.37333782
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.33021541
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.26150874
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22695605
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.08872600
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.74585733
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71835327
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.57786666
10AR_21909140_ChIP-Seq_LNCAP_Human2.53820308
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46778318
12MYC_22102868_ChIP-Seq_BL_Human2.37701437
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22101591
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.17081369
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07632716
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03955092
17E2F7_22180533_ChIP-Seq_HELA_Human10.7777871
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97029081
19* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88180024
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85072546
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81603039
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81325822
23* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77803496
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65295487
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62916381
26ELK1_19687146_ChIP-ChIP_HELA_Human1.61077410
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60416453
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58079220
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53529057
30CIITA_25753668_ChIP-Seq_RAJI_Human1.49639260
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47926545
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47860314
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40223658
34* KDM5A_27292631_Chip-Seq_BREAST_Human1.36292329
35XRN2_22483619_ChIP-Seq_HELA_Human1.36124410
36FUS_26573619_Chip-Seq_HEK293_Human1.35718427
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32782049
38* VDR_23849224_ChIP-Seq_CD4+_Human1.31897650
39GATA1_22025678_ChIP-Seq_K562_Human1.31162429
40EWS_26573619_Chip-Seq_HEK293_Human1.29879905
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26782238
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.23452929
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23311086
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22902034
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.22893449
46MYB_26560356_Chip-Seq_TH1_Human1.21210177
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20448198
48TFEB_21752829_ChIP-Seq_HELA_Human1.20416407
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20276587
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20229577
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18246318
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.17230247
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16146457
54FOXP3_21729870_ChIP-Seq_TREG_Human1.16069967
55* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13273902
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13258080
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13164333
58MYB_26560356_Chip-Seq_TH2_Human1.11724463
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11685796
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11422892
61* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10322029
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09705597
63TCF7_22412390_ChIP-Seq_EML_Mouse1.08902620
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08472864
65VDR_21846776_ChIP-Seq_THP-1_Human1.05934820
66CHD1_26751641_Chip-Seq_LNCaP_Human1.04744152
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03651480
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02668552
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02156352
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01407298
71TTF2_22483619_ChIP-Seq_HELA_Human1.01301393
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00383089
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00178968
74* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00117070
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99637217
76* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99239898
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99057644
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98308568
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98169232
80UTX_26944678_Chip-Seq_JUKART_Human0.98110347
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97557212
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97038894
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96582858
84BRD4_25478319_ChIP-Seq_HGPS_Human0.94981434
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94880630
86* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93845555
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93732810
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.93643050
89MAF_26560356_Chip-Seq_TH1_Human0.93260472
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92846582
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.92473160
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90271974
93* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88359460
94* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88045272
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87824486
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87804685
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86852415
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86357399
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85689292
100SPI1_23547873_ChIP-Seq_NB4_Human0.85001291
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84947330
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84874786
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.84517113
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84467391
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84262365
106GABP_19822575_ChIP-Seq_HepG2_Human0.84183632
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82900994
108DCP1A_22483619_ChIP-Seq_HELA_Human0.82784171
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82517933
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82517933
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82517933
112* ETS1_20019798_ChIP-Seq_JURKAT_Human0.82375426
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81964979
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81887560
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.81849348
116MYC_18940864_ChIP-ChIP_HL60_Human0.80524938
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80507964
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80280238
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79745675
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79733575
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79729842
122TAF15_26573619_Chip-Seq_HEK293_Human0.78523856
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75838897
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74373907
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.73698412
126* SOX9_26525672_Chip-Seq_HEART_Mouse0.71180507
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71176619
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.68854335
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68541824
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.68145514
131* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66063250
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65404227
133* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.64652127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.52674361
2MP0008057_abnormal_DNA_replication3.49951045
3MP0003693_abnormal_embryo_hatching3.30390642
4MP0010352_gastrointestinal_tract_polyps3.30134884
5MP0003077_abnormal_cell_cycle3.08053293
6MP0003111_abnormal_nucleus_morphology3.08000761
7MP0004957_abnormal_blastocyst_morpholog2.80847224
8MP0005076_abnormal_cell_differentiation2.73229827
9MP0010307_abnormal_tumor_latency2.61631070
10MP0002396_abnormal_hematopoietic_system2.33553421
11MP0008877_abnormal_DNA_methylation2.26700669
12MP0000569_abnormal_digit_pigmentation2.22997124
13MP0003705_abnormal_hypodermis_morpholog2.22134493
14MP0008007_abnormal_cellular_replicative2.17377596
15MP0003123_paternal_imprinting2.15660791
16MP0008058_abnormal_DNA_repair2.13679102
17MP0001730_embryonic_growth_arrest2.13402279
18MP0000350_abnormal_cell_proliferation2.04458980
19MP0004808_abnormal_hematopoietic_stem1.96395817
20MP0009697_abnormal_copulation1.94436766
21MP0003121_genomic_imprinting1.87668534
22MP0001672_abnormal_embryogenesis/_devel1.81278650
23MP0005380_embryogenesis_phenotype1.81278650
24MP0003984_embryonic_growth_retardation1.76524716
25MP0004197_abnormal_fetal_growth/weight/1.76096305
26MP0002088_abnormal_embryonic_growth/wei1.73394151
27MP0002084_abnormal_developmental_patter1.66544977
28MP0002086_abnormal_extraembryonic_tissu1.65082245
29MP0001697_abnormal_embryo_size1.59649802
30MP0003566_abnormal_cell_adhesion1.51967710
31MP0003890_abnormal_embryonic-extraembry1.50173906
32MP0002085_abnormal_embryonic_tissue1.49237278
33MP0008932_abnormal_embryonic_tissue1.46738633
34MP0003567_abnormal_fetal_cardiomyocyte1.41655572
35MP0000733_abnormal_muscle_development1.39114963
36MP0002080_prenatal_lethality1.33529227
37MP0003787_abnormal_imprinting1.31565495
38MP0002166_altered_tumor_susceptibility1.30197917
39MP0002006_tumorigenesis1.28085779
40MP0001293_anophthalmia1.26839245
41MP0009053_abnormal_anal_canal1.23643248
42MP0004233_abnormal_muscle_weight1.18848194
43MP0009703_decreased_birth_body1.17610404
44MP0003300_gastrointestinal_ulcer1.17168651
45MP0000703_abnormal_thymus_morphology1.16017104
46MP0003763_abnormal_thymus_physiology1.15499802
47MP0005397_hematopoietic_system_phenotyp1.15322390
48MP0001545_abnormal_hematopoietic_system1.15322390
49MP0003943_abnormal_hepatobiliary_system1.13921783
50MP0002877_abnormal_melanocyte_morpholog1.13879676
51MP0005023_abnormal_wound_healing1.13725541
52MP0009278_abnormal_bone_marrow1.12833902
53MP0005408_hypopigmentation1.12179698
54MP0003221_abnormal_cardiomyocyte_apopto1.10071419
55MP0000428_abnormal_craniofacial_morphol1.10051035
56MP0000490_abnormal_crypts_of1.09485040
57MP0000313_abnormal_cell_death1.09035713
58MP0002019_abnormal_tumor_incidence1.05804022
59MP0001915_intracranial_hemorrhage1.05462918
60MP0003937_abnormal_limbs/digits/tail_de1.05427274
61MP0002398_abnormal_bone_marrow1.01791053
62MP0002925_abnormal_cardiovascular_devel1.01713649
63MP0009672_abnormal_birth_weight0.99678968
64MP0006292_abnormal_olfactory_placode0.99547546
65MP0000432_abnormal_head_morphology0.97531923
66MP0010234_abnormal_vibrissa_follicle0.96756432
67MP0003786_premature_aging0.94905830
68MP0000537_abnormal_urethra_morphology0.94753401
69MP0003935_abnormal_craniofacial_develop0.94500657
70MP0003718_maternal_effect0.93424379
71MP0003091_abnormal_cell_migration0.93356345
72MP0003303_peritoneal_inflammation0.93264419
73MP0008438_abnormal_cutaneous_collagen0.92959776
74MP0006054_spinal_hemorrhage0.91640421
75MP0002233_abnormal_nose_morphology0.89811862
76MP0005621_abnormal_cell_physiology0.87852229
77MP0004185_abnormal_adipocyte_glucose0.86237638
78MP0003828_pulmonary_edema0.86219117
79MP0002722_abnormal_immune_system0.85964977
80MP0003448_altered_tumor_morphology0.85442071
81MP0005187_abnormal_penis_morphology0.84992533
82MP0001346_abnormal_lacrimal_gland0.84984173
83MP0000383_abnormal_hair_follicle0.84778411
84MP0001849_ear_inflammation0.84401110
85MP0003656_abnormal_erythrocyte_physiolo0.84396738
86MP0002092_abnormal_eye_morphology0.84376568
87MP0002697_abnormal_eye_size0.84257257
88MP0003941_abnormal_skin_development0.83767745
89MP0010630_abnormal_cardiac_muscle0.81515217
90MP0001661_extended_life_span0.81423581
91MP0000427_abnormal_hair_cycle0.81066420
92MP0008995_early_reproductive_senescence0.80737514
93MP0001299_abnormal_eye_distance/0.80355313
94MP0002938_white_spotting0.79993761
95MP0003115_abnormal_respiratory_system0.78033688
96MP0000266_abnormal_heart_morphology0.77960581
97MP0000689_abnormal_spleen_morphology0.77873193
98MP0002009_preneoplasia0.77786709
99MP0004264_abnormal_extraembryonic_tissu0.77373758
100MP0010030_abnormal_orbit_morphology0.77335239
101MP0005384_cellular_phenotype0.76361423
102MP0010678_abnormal_skin_adnexa0.76263851
103MP0001929_abnormal_gametogenesis0.76151541
104MP0002210_abnormal_sex_determination0.75350674
105MP0001800_abnormal_humoral_immune0.74998815
106MP0003861_abnormal_nervous_system0.74693860
107MP0000358_abnormal_cell_content/0.72905303
108MP0001145_abnormal_male_reproductive0.72060642
109MP0000647_abnormal_sebaceous_gland0.71265580
110MP0001286_abnormal_eye_development0.71153931
111MP0005367_renal/urinary_system_phenotyp0.69412245
112MP0000516_abnormal_urinary_system0.69412245
113MP0000377_abnormal_hair_follicle0.68847867
114MP0002405_respiratory_system_inflammati0.68306198
115MP0000716_abnormal_immune_system0.67585549
116MP0003755_abnormal_palate_morphology0.67073669
117MP0009333_abnormal_splenocyte_physiolog0.66577046
118MP0003942_abnormal_urinary_system0.66073409
119MP0002429_abnormal_blood_cell0.66066487
120MP0002111_abnormal_tail_morphology0.66066432
121MP0002114_abnormal_axial_skeleton0.65797838
122MP0003385_abnormal_body_wall0.65524104
123MP0002452_abnormal_antigen_presenting0.65246883
124MP0001784_abnormal_fluid_regulation0.64031239
125MP0000653_abnormal_sex_gland0.63236914
126MP0002095_abnormal_skin_pigmentation0.62640918
127MP0002234_abnormal_pharynx_morphology0.61801308
128MP0001727_abnormal_embryo_implantation0.61544148
129MP0002160_abnormal_reproductive_system0.60967161
130MP0001186_pigmentation_phenotype0.59728049

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.47120802
2Abnormality of the fingertips (HP:0001211)3.41945418
3Nephroblastoma (Wilms tumor) (HP:0002667)3.27109535
4Chromsome breakage (HP:0040012)3.13293294
5Embryonal renal neoplasm (HP:0011794)3.10426477
6Long eyelashes (HP:0000527)3.07910697
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03955293
8Short 4th metacarpal (HP:0010044)3.03955293
9Deviation of the thumb (HP:0009603)3.02868276
10Proximal placement of thumb (HP:0009623)2.94592850
11Overlapping toe (HP:0001845)2.85500984
12Cortical dysplasia (HP:0002539)2.82493480
13Ependymoma (HP:0002888)2.79176892
14Increased nuchal translucency (HP:0010880)2.73276768
15Medulloblastoma (HP:0002885)2.73115276
16Ectopic kidney (HP:0000086)2.65918067
17Urethral obstruction (HP:0000796)2.65283834
18Prominent nose (HP:0000448)2.63799643
19Abnormality of chromosome stability (HP:0003220)2.61115745
20Colon cancer (HP:0003003)2.60106118
21Biliary tract neoplasm (HP:0100574)2.56193876
22Duodenal stenosis (HP:0100867)2.50779780
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45682755
24Acute myeloid leukemia (HP:0004808)2.43887863
25Astrocytoma (HP:0009592)2.42542878
26Abnormality of the astrocytes (HP:0100707)2.42542878
27Selective tooth agenesis (HP:0001592)2.35058134
28Spinal cord lesions (HP:0100561)2.29899955
29Syringomyelia (HP:0003396)2.29899955
30Deep philtrum (HP:0002002)2.27657187
31Rhabdomyosarcoma (HP:0002859)2.27069733
32Truncal obesity (HP:0001956)2.25455085
33Abnormal lung lobation (HP:0002101)2.22024169
34Birth length less than 3rd percentile (HP:0003561)2.21490441
35Agnosia (HP:0010524)2.21250816
36Gastrointestinal carcinoma (HP:0002672)2.20437518
37Malignant gastrointestinal tract tumors (HP:0006749)2.20437518
38Missing ribs (HP:0000921)2.18424000
39Abnormality of chromosome segregation (HP:0002916)2.17965877
40Neoplasm of the oral cavity (HP:0100649)2.17239761
41Papillary thyroid carcinoma (HP:0002895)2.16402588
42Low anterior hairline (HP:0000294)2.15700516
43Glioma (HP:0009733)2.14337619
44Sloping forehead (HP:0000340)2.13685996
45Subacute progressive viral hepatitis (HP:0006572)2.11440443
46Blepharitis (HP:0000498)2.10896766
47Ankyloglossia (HP:0010296)2.10591338
48Abnormality of the 4th metacarpal (HP:0010012)2.09296770
49Basal cell carcinoma (HP:0002671)2.08585930
50Abnormality of the duodenum (HP:0002246)2.07765384
51Abnormality of the labia minora (HP:0012880)2.06989767
52Impulsivity (HP:0100710)2.06965123
53Absent frontal sinuses (HP:0002688)2.06377730
54Narrow palate (HP:0000189)2.06015585
55Thyroid carcinoma (HP:0002890)2.05789288
56Trigonocephaly (HP:0000243)2.05118060
57High pitched voice (HP:0001620)2.04617804
58Absent radius (HP:0003974)2.03107510
59Broad thumb (HP:0011304)2.01880664
60Cutis marmorata (HP:0000965)1.99978045
61Clubbing of toes (HP:0100760)1.99810697
62Vertebral arch anomaly (HP:0008438)1.98104451
63Supernumerary ribs (HP:0005815)1.96151207
64Myelodysplasia (HP:0002863)1.94871282
65Shallow orbits (HP:0000586)1.94292242
66Sandal gap (HP:0001852)1.93824020
67Macroorchidism (HP:0000053)1.93650747
68Heterotopia (HP:0002282)1.93036747
69Skull defect (HP:0001362)1.92807882
70Facial hemangioma (HP:0000329)1.92598446
71Rectal prolapse (HP:0002035)1.92584356
72Limited elbow extension (HP:0001377)1.92332161
73Cafe-au-lait spot (HP:0000957)1.89286448
7411 pairs of ribs (HP:0000878)1.88921637
75Cystic hygroma (HP:0000476)1.88095555
76Sparse lateral eyebrow (HP:0005338)1.87575534
77Abnormality of the nasal septum (HP:0000419)1.87564513
78Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85987806
79Increased density of long bones (HP:0006392)1.85932786
80Abnormal number of incisors (HP:0011064)1.85670998
81T lymphocytopenia (HP:0005403)1.85533486
82Amaurosis fugax (HP:0100576)1.85092001
83Atresia of the external auditory canal (HP:0000413)1.84969009
84Long clavicles (HP:0000890)1.84932930
85Embryonal neoplasm (HP:0002898)1.82589922
86Neoplasm of striated muscle (HP:0009728)1.82563259
87Choanal atresia (HP:0000453)1.82356639
88Arteriovenous malformation (HP:0100026)1.82135596
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.80290720
90Absent forearm bone (HP:0003953)1.80231833
91Aplasia involving forearm bones (HP:0009822)1.80231833
92Acute lymphatic leukemia (HP:0006721)1.80045678
93High anterior hairline (HP:0009890)1.79773659
94Meckel diverticulum (HP:0002245)1.77902706
95Broad palm (HP:0001169)1.77867291
96Pelvic girdle muscle weakness (HP:0003749)1.77857655
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.76592942
98Wide nose (HP:0000445)1.75561131
99Hypoplastic labia majora (HP:0000059)1.75304905
100Uterine neoplasm (HP:0010784)1.75231176
101Dislocated radial head (HP:0003083)1.75175307
102Cutaneous melanoma (HP:0012056)1.74909283
103Ankle contracture (HP:0006466)1.74344015
104Tubulointerstitial nephritis (HP:0001970)1.73357007
105Leiomyosarcoma (HP:0100243)1.73149222
106Uterine leiomyosarcoma (HP:0002891)1.73149222
107Supernumerary bones of the axial skeleton (HP:0009144)1.72857784
108Patellar aplasia (HP:0006443)1.72741725
109Broad phalanges of the hand (HP:0009768)1.71749706
110Abnormality of the preputium (HP:0100587)1.71538046
111Gonadotropin excess (HP:0000837)1.71087221
112Abnormality of T cell number (HP:0011839)1.70858544
113Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70728906
114Abnormality of the calcaneus (HP:0008364)1.70227265
115Cerebral aneurysm (HP:0004944)1.69269101
116Neoplasm of the adrenal cortex (HP:0100641)1.69265851
117Abnormality of cochlea (HP:0000375)1.68181421
118Anal stenosis (HP:0002025)1.67877101
119Hypopigmentation of the fundus (HP:0007894)1.67192509
120Facial cleft (HP:0002006)1.66630109
121Obsessive-compulsive behavior (HP:0000722)1.66340431
122Relative macrocephaly (HP:0004482)1.65249857
123Diastasis recti (HP:0001540)1.64817004
124Degeneration of anterior horn cells (HP:0002398)1.64754491
125Abnormality of the anterior horn cell (HP:0006802)1.64754491
126Asymmetry of the thorax (HP:0001555)1.64167467
127Abnormality of the ileum (HP:0001549)1.64130812
128Capillary hemangiomas (HP:0005306)1.63894266
129Skin tags (HP:0010609)1.63449892
130Short middle phalanx of the 5th finger (HP:0004220)1.63240225
131Lip pit (HP:0100267)1.63212312
132Abnormal foot bone ossification (HP:0010675)1.63166005
133Neoplasm of the colon (HP:0100273)1.62565926
134Spinal muscular atrophy (HP:0007269)1.61969536
135Abnormality of the radial head (HP:0003995)1.61949796
136Hematochezia (HP:0002573)1.60891968
137Smooth philtrum (HP:0000319)1.60711029
138Abnormality of oral frenula (HP:0000190)1.60031664
139Abnormality of the carotid arteries (HP:0005344)1.59633749
140Neoplasm of the small intestine (HP:0100833)1.59508302
141Hypospadias (HP:0000047)1.59495172
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.58961277
143Osteolytic defects of the hand bones (HP:0009699)1.58961277
144Curly hair (HP:0002212)1.58949779
145Abnormality of DNA repair (HP:0003254)1.58382141
146Aplasia/Hypoplasia of the patella (HP:0006498)1.57265351
147Small intestinal stenosis (HP:0012848)1.56129592
148Chin dimple (HP:0010751)1.55702265
149Reticulocytopenia (HP:0001896)1.55682400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.12562599
2CDC74.58899431
3NEK22.89263124
4LATS12.60614916
5BRD42.32223894
6WEE12.07786711
7STK101.92429161
8STK31.92189913
9CAMK1D1.86080201
10PBK1.84307047
11TTK1.83611775
12EEF2K1.81095883
13AKT31.77076832
14RPS6KA41.75005339
15ATR1.73954816
16TNIK1.66585477
17NEK11.64288657
18PKN21.63511352
19SRPK11.60039734
20CDK61.57118907
21TAF11.55520656
22SCYL21.54452949
23BRSK21.54398039
24AURKB1.54234406
25PLK31.51693661
26CHEK11.50738845
27TTN1.48307242
28MKNK11.47214073
29CDK41.44761250
30STK41.42562547
31TSSK61.41571526
32PLK11.41541963
33CAMK1G1.41479811
34ACVR1B1.40458789
35MAP3K101.39136709
36PLK41.33851268
37CHEK21.30566586
38* ATM1.30315472
39MTOR1.30137472
40RPS6KB21.25666033
41ALK1.21719624
42CDK71.20813477
43MAP4K11.18838150
44FGFR31.17437791
45PNCK1.16888476
46NUAK11.16343305
47MELK1.15387282
48MKNK21.14921026
49EIF2AK11.13141958
50WNK11.09502501
51CLK11.08819852
52MAP3K81.07383310
53JAK31.06882121
54BCR1.03156652
55NLK0.99646381
56* CDK20.99487252
57MST1R0.99267916
58ICK0.98746921
59PIM10.98005776
60ZAK0.93552224
61FRK0.92007647
62RIPK10.91517554
63PASK0.89063765
64FGFR10.88701101
65KSR10.87452992
66MARK30.85490187
67CHUK0.85384333
68YES10.82606929
69CDK90.80873847
70TGFBR10.79988290
71EIF2AK20.79065128
72* CDK10.78804597
73MET0.74915609
74DMPK0.74364052
75PDGFRB0.74138910
76PDGFRA0.73892600
77BUB10.72920837
78RAF10.72693542
79MST40.70435424
80NEK60.70074877
81LRRK20.69074716
82FGFR40.68597018
83TXK0.65656101
84NEK90.64864571
85PAK20.62910775
86CSNK1D0.61891717
87STK38L0.61594365
88MAP3K20.60883223
89SMG10.60830539
90MAPK140.60757748
91PTK60.60689037
92ITK0.59714778
93* PRKDC0.59082116
94CDK80.58920492
95TRIB30.58381082
96PDK20.58325566
97EPHA20.56319807
98TRPM70.56097902
99BRAF0.54361106
100CSNK1E0.54189990
101FLT30.53550234
102PAK40.50614550
103STK240.50242677
104DYRK30.49787371
105FGFR20.48173710
106CDK30.47829222
107CSNK2A20.47118653
108EIF2AK30.46931833
109JAK10.46886734
110STK390.46644964
111RPS6KA50.46180057
112ERBB30.43068078
113AKT10.41221143
114* MAPK10.40294399
115TEC0.40098709
116GSK3B0.39891822
117BRSK10.39797785
118CCNB10.39076483
119TYK20.38838968
120LATS20.38831672
121PIK3CA0.37257861
122MAPK100.35119387
123BMPR1B0.32510174
124RET0.32456586
125BMX0.32041126
126RPS6KB10.31389285
127CSF1R0.30530505
128EGFR0.30244700
129MAPK80.29949095

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85522678
2Cell cycle_Homo sapiens_hsa041102.76770035
3Mismatch repair_Homo sapiens_hsa034302.76398303
4DNA replication_Homo sapiens_hsa030302.72618909
5* RNA transport_Homo sapiens_hsa030132.66179992
6Spliceosome_Homo sapiens_hsa030402.33959708
7Non-homologous end-joining_Homo sapiens_hsa034502.17897808
8mRNA surveillance pathway_Homo sapiens_hsa030152.04753373
9One carbon pool by folate_Homo sapiens_hsa006702.04126677
10Homologous recombination_Homo sapiens_hsa034401.94057088
11Fanconi anemia pathway_Homo sapiens_hsa034601.91669100
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72267541
13RNA degradation_Homo sapiens_hsa030181.69782603
14p53 signaling pathway_Homo sapiens_hsa041151.66677193
15Nucleotide excision repair_Homo sapiens_hsa034201.66045088
16MicroRNAs in cancer_Homo sapiens_hsa052061.64770004
17Antigen processing and presentation_Homo sapiens_hsa046121.62259818
18Base excision repair_Homo sapiens_hsa034101.59678905
19Small cell lung cancer_Homo sapiens_hsa052221.52189774
20Viral carcinogenesis_Homo sapiens_hsa052031.50370671
21Herpes simplex infection_Homo sapiens_hsa051681.45565574
22Adherens junction_Homo sapiens_hsa045201.43990663
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38669379
24Basal transcription factors_Homo sapiens_hsa030221.35581648
25* Thyroid cancer_Homo sapiens_hsa052161.35161355
26Systemic lupus erythematosus_Homo sapiens_hsa053221.34122189
27HTLV-I infection_Homo sapiens_hsa051661.31631372
28Viral myocarditis_Homo sapiens_hsa054161.31038765
29Chronic myeloid leukemia_Homo sapiens_hsa052201.29013259
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.28135648
31Lysine degradation_Homo sapiens_hsa003101.25852629
32Epstein-Barr virus infection_Homo sapiens_hsa051691.24638959
33Primary immunodeficiency_Homo sapiens_hsa053401.16770795
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16689992
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16476148
36TGF-beta signaling pathway_Homo sapiens_hsa043501.14309689
37mTOR signaling pathway_Homo sapiens_hsa041501.10309085
38RNA polymerase_Homo sapiens_hsa030201.08834229
39Measles_Homo sapiens_hsa051621.08032645
40Colorectal cancer_Homo sapiens_hsa052101.07660924
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04632966
42Hepatitis B_Homo sapiens_hsa051611.04507820
43Prostate cancer_Homo sapiens_hsa052151.02660457
44Proteoglycans in cancer_Homo sapiens_hsa052051.00582737
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00426633
46Pancreatic cancer_Homo sapiens_hsa052120.97636164
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97005291
48Oocyte meiosis_Homo sapiens_hsa041140.96747809
49Leishmaniasis_Homo sapiens_hsa051400.93419182
50T cell receptor signaling pathway_Homo sapiens_hsa046600.90606015
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88346915
52Hippo signaling pathway_Homo sapiens_hsa043900.87358969
53B cell receptor signaling pathway_Homo sapiens_hsa046620.87043927
54Legionellosis_Homo sapiens_hsa051340.86745854
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86427396
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.85625627
57Toxoplasmosis_Homo sapiens_hsa051450.84872707
58Notch signaling pathway_Homo sapiens_hsa043300.83990696
59Influenza A_Homo sapiens_hsa051640.83028532
60Apoptosis_Homo sapiens_hsa042100.82168657
61Selenocompound metabolism_Homo sapiens_hsa004500.81388856
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80811190
63Focal adhesion_Homo sapiens_hsa045100.79785550
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79767181
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76832522
66Acute myeloid leukemia_Homo sapiens_hsa052210.76380506
67FoxO signaling pathway_Homo sapiens_hsa040680.76209626
68Basal cell carcinoma_Homo sapiens_hsa052170.76154229
69* Pathways in cancer_Homo sapiens_hsa052000.76016409
70Hematopoietic cell lineage_Homo sapiens_hsa046400.75832485
71Non-small cell lung cancer_Homo sapiens_hsa052230.75270917
72Osteoclast differentiation_Homo sapiens_hsa043800.74771779
73Endometrial cancer_Homo sapiens_hsa052130.74583145
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.73245610
75HIF-1 signaling pathway_Homo sapiens_hsa040660.72751731
76ErbB signaling pathway_Homo sapiens_hsa040120.71857605
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71746676
78TNF signaling pathway_Homo sapiens_hsa046680.70769283
79Protein export_Homo sapiens_hsa030600.70453679
80ECM-receptor interaction_Homo sapiens_hsa045120.69871862
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.69398155
82Pyrimidine metabolism_Homo sapiens_hsa002400.68208267
83Inositol phosphate metabolism_Homo sapiens_hsa005620.67405479
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.66850158
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.65342994
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64179536
87Ribosome_Homo sapiens_hsa030100.62622646
88Shigellosis_Homo sapiens_hsa051310.62214298
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61470258
90Purine metabolism_Homo sapiens_hsa002300.59655228
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59191187
92Hedgehog signaling pathway_Homo sapiens_hsa043400.58849109
93Renal cell carcinoma_Homo sapiens_hsa052110.58298974
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.56681446
95Platelet activation_Homo sapiens_hsa046110.56502260
96Autoimmune thyroid disease_Homo sapiens_hsa053200.56289525
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56217769
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56197653
99Propanoate metabolism_Homo sapiens_hsa006400.54952347
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54173174
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52814907
102Wnt signaling pathway_Homo sapiens_hsa043100.52509544
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52247055
104Biosynthesis of amino acids_Homo sapiens_hsa012300.49881227
105Choline metabolism in cancer_Homo sapiens_hsa052310.49126108
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48096858
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48092370
108Amoebiasis_Homo sapiens_hsa051460.47562601
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47175330
110Salmonella infection_Homo sapiens_hsa051320.46274369
111Bladder cancer_Homo sapiens_hsa052190.45566571
112Glioma_Homo sapiens_hsa052140.45163533
113Graft-versus-host disease_Homo sapiens_hsa053320.45142825
114Tight junction_Homo sapiens_hsa045300.44679225
115Prolactin signaling pathway_Homo sapiens_hsa049170.44195384
116Melanoma_Homo sapiens_hsa052180.43955924
117Allograft rejection_Homo sapiens_hsa053300.43900214
118Alcoholism_Homo sapiens_hsa050340.43642480
119N-Glycan biosynthesis_Homo sapiens_hsa005100.42316408
120Pyruvate metabolism_Homo sapiens_hsa006200.37183243
121Insulin signaling pathway_Homo sapiens_hsa049100.35740502
122Circadian rhythm_Homo sapiens_hsa047100.35225056
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35156486
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34144933
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32946088
126Steroid biosynthesis_Homo sapiens_hsa001000.30079715
127Pentose phosphate pathway_Homo sapiens_hsa000300.30052653
128Thyroid hormone synthesis_Homo sapiens_hsa049180.24890165
129Carbon metabolism_Homo sapiens_hsa012000.24154448

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